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https://www.readbyqxmd.com/read/28673608/mitochondrial-biology-in-cancer-stem-cells
#1
REVIEW
Rute Loureiro, Katia A Mesquita, Silvia Magalhães-Novais, Paulo J Oliveira, Ignacio Vega-Naredo
Cancer stem cells (CSCs) have been suggested to be responsible for tumor re-growth and relapse. Physiological and morphological knowledge of CSCs may be essential for the development of new therapeutic strategies targeting cancer development, progression, and recurrence. Current research is focused on a deeper understanding of CSCs metabolic profiles, taking into consideration their energy demands. Energy metabolism and mitochondrial function are important factors operating on stemness maintenance and cell fate specification...
June 30, 2017: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/28651798/cycling-to-school-and-body-composition-physical-fitness-and-metabolic-syndrome-in-children-and-adolescents
#2
Robinson Ramírez-Vélez, Antonio García-Hermoso, Cesar Agostinis-Sobrinho, Jorge Mota, Rute Santos, Jorge Enrique Correa-Bautista, Deisy Constanza Amaya-Tambo, Emilio Villa-González
OBJECTIVE: To evaluate the association between cycling to/from school and body composition, physical fitness, and metabolic syndrome among a sample of Colombian children and adolescents. STUDY DESIGN: During the 2014-2015 school year, we examined a cross-sectional component of the Association for muscular strength with early manifestation of cardiovascular disease risk factors among Colombian children and adolescents (FUPRECOL) study. Participants included 2877 youths (54...
June 23, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28595183/association-between-leptin-adiponectin-and-leptin-adiponectin-ratio-with-clustered-metabolic-risk-factors-in-portuguese-adolescents-the-labmed-physical-activity-study
#3
César A Agostinis-Sobrinho, Edmar Lacerda Mendes, Carla Moreira, Sandra Abreu, Luís Lopes, José Oliveira-Santos, Albertas Skurvydas, Jorge Mota, Rute Santos
INTRODUCTION: Circulating leptin and adiponectin levels have been associated with impaired vascular function, insulin resistance, and acute cardiovascular evens. This study aimed to evaluate the associations of leptin, adiponectin, and the leptin/adiponectin (L/A) ratio with a clustering of metabolic risk factors (MRF) in adolescents aged 12-18 years. METHODS: This is a cross-sectional analysis with 529 Portuguese adolescents aged 12-18 years. Blood samples were taken to analyze total cholesterol (TC) and high-density lipoprotein (HDL) cholesterol (HDL-c), triglycerides glucose, insulin, leptin, and adiponectin levels...
2017: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/28579982/the-role-of-ribonucleases-and-srnas-in-the-virulence-of-foodborne-pathogens
#4
REVIEW
Rute G Matos, Jorge Casinhas, Cátia Bárria, Ricardo F Dos Santos, Inês J Silva, Cecília M Arraiano
Contaminated food is the source of many severe infections in humans. Recent advances in food science have discovered new foodborne pathogens and progressed in characterizing their biology, life cycle, and infection processes. All this knowledge has been contributing to prevent food contamination, and to develop new therapeutics to treat the infections caused by these pathogens. RNA metabolism is a crucial biological process and has an enormous potential to offer new strategies to fight foodborne pathogens. In this review, we will summarize what is known about the role of bacterial ribonucleases and sRNAs in the virulence of several foodborne pathogens and how can we use that knowledge to prevent infection...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28273955/lack-of-xpc-leads-to-a-shift-between-respiratory-complexes-i-and-ii-but-sensitizes-cells-to-mitochondrial-stress
#5
Mateus P Mori, Rute A P Costa, Daniela T Soltys, Thiago de S Freire, Franco A Rossato, Ignácio Amigo, Alicia J Kowaltowski, Aníbal E Vercesi, Nadja C de Souza-Pinto
Genomic instability drives tumorigenesis and DNA repair defects are associated with elevated cancer. Metabolic alterations are also observed during tumorigenesis, although a causal relationship between these has not been clearly established. Xeroderma pigmentosum (XP) is a DNA repair disease characterized by early cancer. Cells with reduced expression of the XPC protein display a metabolic shift from OXPHOS to glycolysis, which was linked to accumulation of nuclear DNA damage and oxidants generation via NOX-1...
December 2017: Scientific Reports
https://www.readbyqxmd.com/read/28208831/resveratrol-and-grape-extract-loaded-solid-lipid-nanoparticles-for-the-treatment-of-alzheimer-s-disease
#6
Joana A Loureiro, Stephanie Andrade, Ana Duarte, Ana Rute Neves, Joana Fontes Queiroz, Cláudia Nunes, Emmanuel Sevin, Laurence Fenart, Fabien Gosselet, Manuel A N Coelho, Maria Carmo Pereira
The aggregation of amyloid-β peptide (Aβ) has been linked to the formation of neuritic plaques, which are pathological hallmarks of Alzheimer's disease (AD). Various natural compounds have been suggested as therapeutics for AD. Among these compounds, resveratrol has aroused great interest due to its neuroprotective characteristics. Here, we provide evidence that grape skin and grape seed extracts increase the inhibition effect on Aβ aggregation. However, after intravenous injection, resveratrol is rapidly metabolized into both glucuronic acid and sulfate conjugations of the phenolic groups in the liver and intestinal epithelial cells (within less than 2 h), which are then eliminated...
February 13, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27923992/sinorhizobium-meliloti-ybey-is-an-endoribonuclease-with-unprecedented-catalytic-features-acting-as-silencing-enzyme-in-riboregulation
#7
Margarida Saramago, Alexandra Peregrina, Marta Robledo, Rute G Matos, Rolf Hilker, Javier Serrania, Anke Becker, Cecilia M Arraiano, José I Jiménez-Zurdo
Structural and biochemical features suggest that the almost ubiquitous bacterial YbeY protein may serve catalytic and/or Hfq-like protective functions central to small RNA (sRNA)-mediated regulation and RNA metabolism. We have biochemically and genetically characterized the YbeY ortholog of the legume symbiont Sinorhizobium meliloti (SmYbeY). Co-immunoprecipitation (CoIP) with a FLAG-tagged SmYbeY yielded a poor enrichment in RNA species, compared to Hfq CoIP-RNA uncovered previously by a similar experimental setup...
December 6, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27254445/in-vitro-antifungal-activity-of-four-chemotypes-of-lippia-alba-verbenaceae-essential-oils-against-alternaria-solani-pleosporeaceae-isolates
#8
Elisa Z Tomazoni, Márcia R Pansera, Gabriel F Pauletti, Sidnei Moura, Rute T S Ribeiro, Joséli Schwambach
Several volatile natural compounds produced by plant secondary metabolism have been proven to present antimicrobial action, enabling their use in phytopathogen control. They also present low environmental impact when compared to conventional pesticides. Essential oils contain these compounds and can be found in several plant species, such as Lippia alba (Mill.) N.E. Brown (Verbenaceae). Essential oils of four chemotypes of L. alba, characterized by their major compounds, namely camphor, citral, linalool and camphor/1,8-cineole, were tested against the phytopathogen Alternaria solani Sorauer (Pleosporaceae), which causes early blight on tomatoes and is responsible for great economic losses regarding production...
May 31, 2016: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/26824273/ability-of-measures-of-adiposity-in-identifying-adverse-levels-of-inflammatory-and-metabolic-markers-in-adolescents
#9
José Oliveira-Santos, Rute Santos, Carla Moreira, Sandra Abreu, Luís Lopes, César Agostinis, Jorge Mota
BACKGROUND: Overweight and obesity have been associated with a pro-inflammatory state. We aimed to assess the ability of different measures of overall and abdominal adiposity for identifying adverse levels of inflammatory and metabolic markers in adolescents. METHODS: This is a cross-sectional analysis with 529 Portuguese adolescents (267 girls), mean age 14.3 ± 1.7 years. Weight, height, sitting height, waist circumference (WC), and body fat percentage (BF%) were measured; and BMI, waist-to-height ratio (WHtR), and waist-to-sitting-height ratio (WsHtR) were calculated...
April 2016: Childhood Obesity
https://www.readbyqxmd.com/read/26643314/long-live-foxo-unraveling-the-role-of-foxo-proteins-in-aging-and-longevity
#10
REVIEW
Rute Martins, Gordon J Lithgow, Wolfgang Link
Aging constitutes the key risk factor for age-related diseases such as cancer and cardiovascular and neurodegenerative disorders. Human longevity and healthy aging are complex phenotypes influenced by both environmental and genetic factors. The fact that genetic contribution to lifespan strongly increases with greater age provides basis for research on which "protective genes" are carried by long-lived individuals. Studies have consistently revealed FOXO (Forkhead box O) transcription factors as important determinants in aging and longevity...
April 2016: Aging Cell
https://www.readbyqxmd.com/read/26603002/menkes-disease-importance-of-diagnosis-with-molecular-analysis-in-the-neonatal-period
#11
Larissa Sampaio de Athayde Costa, Stephanie Pucci Pegler, Rute Facchini Lellis, Vera Lúcia Jornada Krebs, Stephen Robertson, Tim Morgan, Rachel Sayuri Honjo, Débora Romeo Bertola, Chong Ae Kim
Menkes disease is a congenital disorder caused by changes in copper metabolism derived from mutations in the ATP7A gene. It is characterized by physical and neurological alterations. In the neonatal period, these alterations can be nonspecific, which makes early diagnosis a challenge. Diagnosis can be suspected when there are low levels of ceruloplasmin and serum copper. Molecular analysis confirms the diagnosis. Treatment is parenteral administration of copper histidine. We report a familial case with molecular confirmation...
September 2015: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/26351202/shotgun-analysis-of-the-marine-mussel-mytilus-edulis-hemolymph-proteome-and-mapping-the-innate-immunity-elements
#12
Alexandre Campos, Itxaso Apraiz, Rute R da Fonseca, Susana Cristobal
The marine mussel innate immunity provides protection to pathogen invasion and inflammation. In this regard, the mussel hemolymph takes a main role in the animal innate response. Despite the importance of this body fluid in determining the physiological condition of the animal, little is known about the molecular mechanisms underlying the cellular and humoral responses. In this work, we have applied a MS (nano-LC-MS/MS) strategy integrating genomic and transcriptomic data with the aim to: (i) identify the main protein functional groups that characterize hemolymph and (ii) to map the elements of innate immunity in the marine mussel Mytilus edulis hemolymph proteome...
December 2015: Proteomics
https://www.readbyqxmd.com/read/26135459/unravelling-the-evolution-of-the-allatostatin-type-a-kiss-and-galanin-peptide-receptor-gene-families-in-bilaterians-insights-from-anopheles-mosquitoes
#13
Rute C Felix, Marlene Trindade, Isa R P Pires, Vera G Fonseca, Rute S Martins, Henrique Silveira, Deborah M Power, João C R Cardoso
UNLABELLED: Allatostatin type A receptors (AST-ARs) are a group of G-protein coupled receptors activated by members of the FGL-amide (AST-A) peptide family that inhibit food intake and development in arthropods. Despite their physiological importance the evolution of the AST-A system is poorly described and relatively few receptors have been isolated and functionally characterised in insects. The present study provides a comprehensive analysis of the origin and comparative evolution of the AST-A system...
2015: PloS One
https://www.readbyqxmd.com/read/26025920/melatonin-antiproliferative-effects-require-active-mitochondrial-function-in-embryonal-carcinoma-cells
#14
Rute Loureiro, Silvia Magalhães-Novais, Katia A Mesquita, Ines Baldeiras, Isabel S Sousa, Ludgero C Tavares, Ines A Barbosa, Paulo J Oliveira, Ignacio Vega-Naredo
Although melatonin oncostatic and cytotoxic effects have been described in different types of cancer cells, the specific mechanisms leading to its antitumoral effects and their metabolic context specificity are still not completely understood. Here, we evaluated the effects of melatonin in P19 embryonal carcinoma stem cells (CSCs) and in their differentiated counterparts, cultured in either high glucose medium or in a galactose (glucose-free) medium which leads to glycolytic suppression and increased mitochondrial metabolism...
July 10, 2015: Oncotarget
https://www.readbyqxmd.com/read/25826206/host-glycan-sugar-specific-pathways-in-streptococcus-pneumoniae-galactose-as-a-key-sugar-in-colonisation-and-infection-corrected
#15
Laura Paixão, Joana Oliveira, André Veríssimo, Susana Vinga, Eva C Lourenço, M Rita Ventura, Morten Kjos, Jan-Willem Veening, Vitor E Fernandes, Peter W Andrew, Hasan Yesilkaya, Ana Rute Neves
The human pathogen Streptococcus pneumoniae is a strictly fermentative organism that relies on glycolytic metabolism to obtain energy. In the human nasopharynx S. pneumoniae encounters glycoconjugates composed of a variety of monosaccharides, which can potentially be used as nutrients once depolymerized by glycosidases. Therefore, it is reasonable to hypothesise that the pneumococcus would rely on these glycan-derived sugars to grow. Here, we identified the sugar-specific catabolic pathways used by S. pneumoniae during growth on mucin...
2015: PloS One
https://www.readbyqxmd.com/read/25666790/shutting-down-the-furnace-preferential-killing-of-cancer-cells-with-mitochondrial-targeting-molecules
#16
REVIEW
Cláudia M Deus, Gabriela L Santos, Rute Loureiro, Ignacio Vega-Naredo, Henrique Faneca, Paulo J Oliveira
Mitochondria are organelles which play an important role not only in cellular metabolism but also in controlling pathways related with cell death, ionic and redox regulation. Alterations in mitochondrial metabolism are implicated in a variety of diseases, including cancer. Cellular and mitochondrial metabolism are both altered during the different stages of tumor development. As cancer cells have altered metabolic profiles, these alterations are a valid and promising target for anti-cancer agents. We hereby review several molecules that are in different stages of development and which target mitochondria in cancer cells...
2015: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/25267350/influence-of-temperature-and-humidity-manipulation-on-chicken-embryonic-development
#17
Rute M Noiva, António C Menezes, Maria C Peleteiro
BACKGROUND: Temperature and relative humidity (RH) are very important factors affecting embryo development, hatchability, and posthatch performance. This study aimed at characterizing embryonic metabolic and behavioural response to a harsh incubation environment generated by manipulations (elevations and drops) in these two key factors. This study was aimed at establishing patterns of metabolic and behavioural response, as well as mortality and the development of malformations, all of which can potentially be used in monitoring incubating operations and diagnosing problems with faulty equipment...
2014: BMC Veterinary Research
https://www.readbyqxmd.com/read/25245810/lactate-dehydrogenase-is-the-key-enzyme-for-pneumococcal-pyruvate-metabolism-and-pneumococcal-survival-in-blood
#18
Paula Gaspar, Firas A Y Al-Bayati, Peter W Andrew, Ana Rute Neves, Hasan Yesilkaya
Streptococcus pneumoniae is a fermentative microorganism and causes serious diseases in humans, including otitis media, bacteremia, meningitis, and pneumonia. However, the mechanisms enabling pneumococcal survival in the host and causing disease in different tissues are incompletely understood. The available evidence indicates a strong link between the central metabolism and pneumococcal virulence. To further our knowledge on pneumococcal virulence, we investigated the role of lactate dehydrogenase (LDH), which converts pyruvate to lactate and is an essential enzyme for redox balance, in the pneumococcal central metabolism and virulence using an isogenic ldh mutant...
December 2014: Infection and Immunity
https://www.readbyqxmd.com/read/25016048/novel-galanin-receptors-in-teleost-fish-identification-expression-and-regulation-by-sex-steroids
#19
Rute S T Martins, Patrícia I S Pinto, Pedro M Guerreiro, Silvia Zanuy, Manuel Carrillo, Adelino V M Canário
In fish, the onset of puberty, the transition from juvenile to sexually reproductive adult animals, is triggered by the activation of pituitary gonadotropin secretion and its timing is influenced by external and internal factors that include the growth/adiposity status of the animal. Kisspeptins have been implicated in the activation of puberty but peripheral signals coming from the immature gonad or associated to the metabolic/nutritional status are also thought to be involved. Therefore we hypothesize the importance of the galinergic system in the brain and testis of pre-pubertal male sea bass as a candidate to translate the signals leading to activation of testicular maturation...
September 1, 2014: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/24964211/fatty-acid-synthase-inhibitors-induce-apoptosis-in-non-tumorigenic-melan-a-cells-associated-with-inhibition-of-mitochondrial-respiration
#20
Franco A Rossato, Karina G Zecchin, Paolo G La Guardia, Rose M Ortega, Luciane C Alberici, Rute A P Costa, Rodrigo R Catharino, Edgard Graner, Roger F Castilho, Aníbal E Vercesi
The metabolic enzyme fatty acid synthase (FASN) is responsible for the endogenous synthesis of palmitate, a saturated long-chain fatty acid. In contrast to most normal tissues, a variety of human cancers overexpress FASN. One such cancer is cutaneous melanoma, in which the level of FASN expression is associated with tumor invasion and poor prognosis. We previously reported that two FASN inhibitors, cerulenin and orlistat, induce apoptosis in B16-F10 mouse melanoma cells via the intrinsic apoptosis pathway. Here, we investigated the effects of these inhibitors on non-tumorigenic melan-a cells...
2014: PloS One
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