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Retinal hemorrhage infants

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https://www.readbyqxmd.com/read/28494564/-clinical-observation-and-related-factors-analysis-of-neonatal-asphyxia-complicated-with-retinal-hemorrhage
#1
Q L Pu, Q Y Zhou, J Liu, P Li, H F Huang, H Q Jiang
Objective: To observe and analyze related factors of neonatal asphyxia complicated with retinal hemorrhage. Methods: It was a retrospective case series. Seven hundred and twenty-one cases with neonatal asphyxia after 72 hours of birth were enrolled in this study. Fundus examination was performed on these newborns using the third generation wide-angle digital retina imaging system (RetCamⅢ), and the bleeding level was divided into level I, level Ⅱ and level Ⅲ. The conditions of the newborn and the mother during pregnancy were correlatively analyzed...
May 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28465833/asymmetric-outcomes-of-type-1-retinopathy-of-prematurity-after-bilateral-intravitreal-ranibizumab-treatment
#2
Qiujing Huang, Qi Zhang, Yu Xu, Xunda Ji, Ping Fei, Jie Peng, Yi-An Li, Peiquan Zhao
Purpose. To present cases with retinopathy of prematurity (ROP), who were treated with intravitreal injection of ranibizumab (IVR) and had unpredictable asymmetric outcomes. Methods. A retrospective review was performed in infants with type 1 ROP and had bilateral IVR (0.25 mg/0.025 mL) as initial treatment. Patients were classified into the asymmetric outcome group and the symmetric outcome group. Results. Eighty-four patients (168 eyes) were included. There were 18 eyes of 9 patients (10.7%) in the asymmetric outcome group and 150 eyes of 75 patients (89...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28439195/the-role-of-serial-measurements-of-serum-insulin-like-growth-factor-1-levels-in-the-development-of-retinopathy-of-prematurity
#3
Bayram Ali Dorum, Cansu Canbolat Yılmaz, Nilgün Köksal, Hilal Özkan, Meral Yıldız, Ahmet Tuncer Özmen
AIM: To determine the role of serum insulin-like growth factor-1 levels in the development of retinopathy of prematurity, which is a major cause of childhood blindness worldwide. MATERIAL AND METHODS: We prospectively studied newborn infants born at a postmenstrual age of <32 weeks and birth weights <1 500 gr, between January 1(st), 2015, and December 31(st), 2015. A total of 40 infants were enrolled in the study. The retinal examination time was determined in accordance with the American Academy of Pediatrics recommendations for retinopathy of prematurity screening and follow-up...
March 2017: Türk Pediatri Arşivi
https://www.readbyqxmd.com/read/28393562/intravitreal-anti-vegf-treatment-for-retinopathy-of-prematurity-in-infants-with-active-adenoviral-keratoconjunctivitis
#4
Yusuf Koçluk, Emine Alyamaç Sukgen
PURPOSE: To evaluate the results of intravitreal anti-vascular endothelial growth factor (anti-VEGF) treatment for retinopathy of prematurity (ROP) in infants with active adenoviral keratoconjunctivitis (AKC). MATERIAL AND METHODS: A retrospective analysis was performed using the medical records of all infants treated with intravitreal injections of anti-VEGF agents during an AKC outbreak previously reported in the literature at a tertiary center for treatment of ROP...
April 27, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28384676/microscope-integrated-optical-coherence-tomography-angiography-in-the-operating-room-in-young-children-with-retinal-vascular-disease
#5
Xi Chen, Christian Viehland, Oscar M Carrasco-Zevallos, Brenton Keller, Lejla Vajzovic, Joseph A Izatt, Cynthia A Toth
Importance: Intraoperative optical coherence tomography (OCT) has gained traction as an important adjunct for clinical decision making during vitreoretinal surgery, and OCT angiography (OCTA) has provided novel insights in clinical evaluation of retinal diseases. To date, these two technologies have not been applied in combination to evaluate retinal vascular disease in the operating suite. Objective: To conduct microscope-integrated, swept-source OCTA (MIOCTA) in children with retinal vascular disease...
May 1, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28367531/bilateral-cytomegalovirus-retinitis-in-a-healthy-infant
#6
Seyedeh Maryam Hosseini, Mir-Naghi Moosavi, Naser Shoeibi, Mehdi Sakhaee, Hossein Ghavamsaeedi
PURPOSE: To report a case of bilateral cytomegalovirus (CMV) retinitis in an otherwise healthy infant. METHODS: A four-month-old, healthy, male infant was evaluated for visual inattention. RESULTS: This full-term infant with a normal birth weight and an uneventful gestational period was referred with symptoms of visual inattention, fever, and agitation one week prior to admission. Ocular involvements were detected in the form of bilateral pan uveitis with diffuse bilateral retinitis and vasculitis with hemorrhage in the peripheral retina and posterior pole...
March 2017: Journal of Current Ophthalmology
https://www.readbyqxmd.com/read/28190553/cervical-spine-imaging-for-young-children-with-inflicted-trauma-expanding-the-injury-pattern
#7
Joanne Baerg, Arul Thirumoorthi, Rosemary Vannix, Asma Taha, Amy Young, Alexander Zouros
AIM: The purpose of this study was to document the incidence and pattern of cervical spine (c-spine) injuries in children below 36months with inflicted trauma. METHODS: An IRB approved, prospective cohort study was performed between July 2011 and January 2016. Inclusion criteria were: age below 36months, loss of consciousness after inflicted trauma, and one initial head computed tomography finding: a subdural, intraventricular, intraparenchymal, subarachnoid hemorrhage, diffuse axonal injury, hypoxic injury, or cerebral edema...
May 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28104500/photographic-assessment-of-retinal-hemorrhages-in-infant-head-injury-the-childhood-hemorrhagic-retinopathy-study
#8
Gaurav Bhardwaj, Mark B Jacobs, Frank J Martin, Kieran T Moran, Kristina Prelog, Craig Donaldson, Ute Vollmer-Conna, Minas T Coroneo
BACKGROUND: Retinal hemorrhages (RH) in babies in the absence of severe trauma or a medical cause have been strongly associated with abusive head trauma (AHT). We examined the pattern of RH in accidental head injury and AHT objectively using widefield retinal imaging. METHODS: A total of 118 infants and children 1-36 months of age admitted with head injuries at two centers were included in this prospective, consecutive, comparative cohort study. Dilated fundus examination was performed with indirect ophthalmoscopy and widefield imaging...
February 2017: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/28043398/col4a1-mutation-in-a-neonate-with-intrauterine-stroke-and-anterior-segment-dysgenesis
#9
Shaheen Durrani-Kolarik, Kandamurugu Manickam, Bernadette Chen
BACKGROUND: COL4A1 on chromosome 13q34 encodes the alpha 1 chain of type IV collagen, a component of basal membranes. It is expressed mainly in the brain, muscles, kidneys, and eyes. COL4A1 mutations can remain asymptomatic or cause devastating disease. Neonates and children may present with porencephaly, intracerebral hemorrhage, or hemiparesis, whereas adults tend to develop intracranial aneurysms or retinal arteriolar tortuosities. PATIENT DESCRIPTION: We describe a term infant with encephalomalacia, extensive intrauterine stroke and anterior segment dysgenesis with a de novo mutation in COL4A1...
January 2017: Pediatric Neurology
https://www.readbyqxmd.com/read/27992937/parenteral-fish-oil-lipid-emulsions-in-the-prevention-of-severe-retinopathy-of-prematurity-a-systematic-review-and-meta-analysis
#10
Sakeer Vayalthrikkovil, Rani A Bashir, Yacov Rabi, Harish Amin, Jill-Marie Spence, Helen Lee Robertson, Abhay Lodha
Objective Omega-3 fatty acids are vital for brain and retinal maturation. It is not clear if early use of ω-3 fatty acids in the form of fish-oil lipid emulsions (FLEs) prevents retinopathy of prematurity (ROP) in preterm infants. The aim of this meta-analysis is to evaluate whether early administration of parenteral FLEs reduces ROP requiring laser therapy or severe ROP ≥stage 3 in preterm infants. Methods A literature search was performed to identify studies comparing parenteral FLEs with soybean-based lipid emulsions (SLEs) in preventing ROP...
June 2017: American Journal of Perinatology
https://www.readbyqxmd.com/read/27986386/intraocular-hemorrhages-and-retinopathy-of-prematurity-in-the-telemedicine-approaches-to-evaluating-acute-phase-retinopathy-of-prematurity-e-rop-study
#11
Ebenezer Daniel, Gui-Shuang Ying, R Michael Siatkowski, Wei Pan, Eli Smith, Graham E Quinn
PURPOSE: To describe the clinical characteristics of intraocular hemorrhages (IOHs) in infants in the Telemedicine Approaches to Evaluating Acute-Phase Retinopathy of Prematurity (e-ROP) Study and to evaluate their potential use for prediction of disease severity. DESIGN: Secondary data analysis from a prospective study. PARTICIPANTS: Preterm infants with birth weight (BW) ≤1250 g. METHODS: Infants underwent serial digital retinal imaging in both eyes starting at 32 weeks' postmenstrual age...
March 2017: Ophthalmology
https://www.readbyqxmd.com/read/27982430/severe-retinal-hemorrhages-with-retinoschisis-in-infants-are-not-pathognomonic-for-abusive-head-trauma
#12
Mark J Shuman, Kenneth D Hutchins
The combination of subdural hemorrhage (SDH), retinal hemorrhage (RH), and encephalopathy, or the presence of severe retinal hemorrhages alone in infants, is often attributed to and has been stated to be pathognomonic for abusive head trauma (AHT) or shaken baby syndrome. These beliefs have been challenged, because the same constellation of findings has been identified in accidental head injuries and natural diseases, and most if not all of the studies that support the concept of diagnostic specificity have serious flaws in their methodology...
May 2017: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/27918825/early-postnatal-hyperoxia-in-mice-leads-to-severe-persistent-vitreoretinopathy
#13
Paul G McMenamin, Rachel Kenny, Sjakon Tahija, Jeremiah Lim, Cecilia Naranjo Golborne, Xiangting Chen, Sheena Bouch, Foula Sozo, Bang Bui
Purpose: To describe a mouse model of hyperoxia-induced vitreoretinopathy that replicated some of the clinical and pathologic features encountered in infants with severe retinopathy of prematurity and congenital ocular conditions such as persistent hyperplastic primary vitreous. Methods: Experimental mice (C57BL/6J) were exposed to 65% oxygen between postnatal days (P)0 to P7 and studied at P10, P14, and 3, 5, 8, 20, and 40 weeks. Controls were exposed to normoxic conditions...
December 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27783389/persistent-retinal-iron-in-abusive-head-trauma
#14
Babette Bais, Wouter A Karst, Bela Kubat, Robert M Verdijk
Retinal hemosiderin deposition is a histologic indicator of sustained hemorrhage but cannot be used to precisely estimate the elapsed time since an episode of trauma. A 5-month-old male infant was admitted to hospital after acute deterioration. Examination revealed encephalopathy, subdural hematomas, and retinal hemorrhages consistent with abusive head trauma (AHT). At the age of 3, he was readmitted to hospital with spontaneous osteopenic fracture of the right femur. The patient deteriorated and died after unsuccessful resuscitation...
November 2016: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/27720550/igf-i-in-the-clinics-use-in-retinopathy-of-prematurity
#15
REVIEW
Ann Hellström, David Ley, Ingrid Hansen-Pupp, Boubou Hallberg, Luca A Ramenghi, Chatarina Löfqvist, Lois E H Smith, Anna-Lena Hård
Retinopathy of prematurity is a potentially blinding disease, which is associated with low neonatal IGF-I serum concentrations and poor growth. In severe cases impaired retinal vessel growth is followed by pathologic neovascularization, which may lead to retinal detachment. IGF-I may promote growth even in catabolic states. Treating preterm infants with recombinant human (rh) IGF-I to concentrations normally found during gestation has been suggested to have a preventative effect on ROP. A recent phase 2 study treating infants (gestational age between 23weeks+0days and 27weeks +6days) with rhIGF-I/IGF binding protein-3 until 30 postmenstrual weeks showed no effect on ROP but a 53% reduction in severe bronchopulmonary dysplasia and 44% reduction in severe intraventricular hemorrhage...
October 2016: Growth Hormone & IGF Research
https://www.readbyqxmd.com/read/27603537/role-of-insulinlike-growth-factor-1-in-fetal-development-and-in-the-early-postnatal-life-of-premature-infants
#16
Ann Hellström, David Ley, Ingrid Hansen-Pupp, Boubou Hallberg, Luca A Ramenghi, Chatarina Löfqvist, Lois E H Smith, Anna-Lena Hård
The neonatal period of very preterm infants is often characterized by a difficult adjustment to extrauterine life, with an inadequate nutrient supply and insufficient levels of growth factors, resulting in poor growth and a high morbidity rate. Long-term multisystem complications include cognitive, behavioral, and motor dysfunction as a result of brain damage as well as visual and hearing deficits and metabolic disorders that persist into adulthood. Insulinlike growth factor 1 (IGF-1) is a major regulator of fetal growth and development of most organs especially the central nervous system including the retina...
September 2016: American Journal of Perinatology
https://www.readbyqxmd.com/read/27491396/risk-score-for-predicting-treatment-requiring-retinopathy-of-prematurity-rop-in-the-telemedicine-approaches-to-evaluating-acute-phase-rop-study
#17
Gui-Shuang Ying, Deborah VanderVeen, Ebenezer Daniel, Graham E Quinn, Agnieshka Baumritter
PURPOSE: To develop a risk score for predicting treatment-requiring retinopathy of prematurity (TR-ROP) in the Telemedicine Approaches to Evaluating Acute-Phase Retinopathy of Prematurity (e-ROP) study. DESIGN: Second analyses of an observational cohort study. PARTICIPANTS: Infants with birth weight (BW) <1251 g who had ≥1 imaging session by 34 weeks of postmenstrual age (PMA) and ≥1 subsequent retinopathy of prematurity (ROP) examination for determining TR-ROP by study-certified ophthalmologists...
October 2016: Ophthalmology
https://www.readbyqxmd.com/read/27460664/prevalence-of-retinal-hemorrhages-in-infants-presenting-with-isolated-long-bone-fractures-and-evaluation-for-abuse
#18
Brian S Payne, Timothy J Kutz, Ann Di Maio, James M Gerard
BACKGROUND: Fractures are a frequent reason for emergency department visits and evaluation for abusive head trauma is an associated concern in infants. Recent guidelines have suggested that retinal examination may not be necessary in the absence of intracranial injury, but there is a lack of empirical evidence in infants < 1 year of age. OBJECTIVE: Our aim was to evaluate the prevalence of retinal hemorrhages in infants with isolated long bone fractures. METHODS: Retrospective chart review of infants < 1 year of age who presented to an urban, tertiary care pediatric hospital between January 2004 and April 2014 with the diagnosis of an acute long bone fracture or retinal hemorrhages...
October 2016: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27422215/accuracy-of-the-history-of-injury-obtained-from-the-caregiver-in-infantile-head-trauma
#19
MULTICENTER STUDY
Shunsuke Amagasa, Hikoro Matsui, Satoshi Tsuji, Takashi Moriya, Kosaku Kinoshita
OBJECTIVE: We investigated the accuracy of parental reports of infant trauma history. METHODS: We retrospectively reviewed 166 infants from 3 tertiary institutions in Japan that had suffered a traumatic intracranial hemorrhage between 2002 and 2013. The infants were classified into 3 groups based on the parents' report of the mechanism of injury: the low-risk group consisted of injuries sustained from falling off a height below 3 ft. (n=84); the middle-to-high-risk group comprised other mechanisms of injury (n=54); and the unknown-risk group consisted of unknown mechanisms of injury (n=28)...
September 2016: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27402215/abusive-head-trauma-an-epidemiological-and-cost-analysis
#20
Scott Boop, Mary Axente, Blakely Weatherford, Paul Klimo
OBJECTIVE Research on pediatric abusive head trauma (AHT) has largely focused on clinical presentation and management. The authors sought to review a single-institution experience from a public health perspective to gain a better understanding of the local population affected, determine overall incidence and seasonal trends, and provide details on the initial hospitalization, including extent of injuries, neurosurgical interventions, and hospital charges. METHODS All cases of AHT involving patients who presented to Le Bonheur Children's Hospital (LBCH) from 2009 through 2014 were identified...
November 2016: Journal of Neurosurgery. Pediatrics
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