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https://www.readbyqxmd.com/read/28823054/recent-advances-in-synthetic-lipopeptides-as-anti-microbial-agents-designs-and-synthetic-approaches
#1
REVIEW
Jun-Jie Koh, Shuimu Lin, Roger W Beuerman, Shouping Liu
Infectious diseases impose serious public health burdens and continue to be a global public health crisis. The treatment of infections caused by multidrug-resistant pathogens is challenging because only a few viable therapeutic options are clinically available. The emergence and risk of drug-resistant superbugs and the dearth of new classes of antibiotics have drawn increasing awareness that we may return to the pre-antibiotic era. To date, lipopeptides have been received considerable attention because of the following properties: They exhibit potent antimicrobial activities against a broad spectrum of pathogens, rapid bactericidal activity and have a different antimicrobial action compared with most of the conventional antibiotics used today and very slow development of drug resistance tendency...
August 19, 2017: Amino Acids
https://www.readbyqxmd.com/read/28822977/are-green-cities-healthy-and-equitable-unpacking-the-relationship-between-health-green-space-and-gentrification
#2
Helen V S Cole, Melisa Garcia Lamarca, James J T Connolly, Isabelle Anguelovski
While access and exposure to green spaces has been shown to be beneficial for the health of urban residents, interventions focused on augmenting such access may also catalyse gentrification processes, also known as green gentrification. Drawing from the fields of public health, urban planning and environmental justice, we argue that public health and epidemiology researchers should rely on a more dynamic model of community that accounts for the potential unintended social consequences of upstream health interventions...
August 19, 2017: Journal of Epidemiology and Community Health
https://www.readbyqxmd.com/read/28822851/-why-are-we-not-doing-more-for-them-genocide-prevention-lessons-from-the-kindertransport
#3
J Angel, D P Evans
OBJECTIVES: Genocide remains one of the most widespread forms of preventable mortality and morbidity for children today. Despite the creation of multiple human rights treaties, genocide has not been eliminated and its effects disproportionally impact children. The Kindertransport was a series of rescue efforts that brought thousands of refugee children to the United Kingdom from Nazi Germany between 1938 and 1940. This qualitative study asks what public health professionals can learn from the prevention efforts of the Kindertransport by examining the experiences and reflections of individuals rescued as children...
August 17, 2017: Public Health
https://www.readbyqxmd.com/read/28822645/diphtheria-vaccine-who-position-paper-august-2017-recommendations
#4
World Health Organization
This article presents the World Health Organization's (WHO) recommendations on the use of diphtheria vaccines excerpted from the Diphtheria vaccines: WHO position paper, August 2017, published in the Weekly Epidemiological Record (Diphtheria vaccine, 2017) [1]. This position paper replaces the 2006 WHO position paper on diphtheria vaccine (Diphtheria vaccine, 2006) [2]. The position paper incorporates recent evidence on diphtheria and provides revised recommendations on the optimal number of doses and timing of diphtheria vaccination...
August 16, 2017: Vaccine
https://www.readbyqxmd.com/read/28822618/the-impact-of-incident-depression-on-medication-adherence-in-patients-with-type-2-diabetes
#5
C Lunghi, A Zongo, J Moisan, J-P Grégoire, L Guénette
BACKGROUND: Depression has been correlated with suboptimal adherence to antidiabetic drugs (ADs). Most studies on this topic were cross-sectional; thus, the directionality of this relationship could not be established. The objective of this study was to measure the association between incident depression and AD nonadherence among newly treated patients with diabetes. METHODS: We performed a population-based cohort study among new AD users using the Quebec public health insurance data...
August 16, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28822594/-grade-evidence-to-decision-etd-frameworks-a-systematic-and-transparent-approach-to-making-well-informed-healthcare-choices-1-introduction
#6
Pablo Alonso-Coello, Holger J Schünemann, Jenny Moberg, Romina Brignardello-Petersen, Elie A Akl, Marina Davoli, Shaun Treweek, Reem A Mustafa, Gabriel Rada, Sarah Rosenbaum, Angela Morelli, Gordon H Guyatt, Andrew D Oxman
Clinicians, guideline developers, and policymakers sometimes neglect important criteria, give undue weight to criteria, and do not use the best available evidence to inform their judgments. Explicit and transparent systems for decision making can help to ensure that all important criteria are considered and that decisions are informed by the best available research evidence. The GRADE Working Group has developed Evidence to Decision (EtD) frameworks for the different type of recommendations or decisions. The purpose of EtD frameworks is to help people use evidence in a structured and transparent way to inform decisions in the context of clinical recommendations, coverage decisions, and health system or public health recommendations and decisions...
August 16, 2017: Gaceta Sanitaria
https://www.readbyqxmd.com/read/28822321/neurostimulation-techniques-in-the-treatment-of-cocaine-dependence-a-review-of-the-literature
#7
REVIEW
Fady Rachid
OBJECTIVE: Cocaine use disorder is a very common condition that represents a substantial public health problem, and no effective pharmacological or psychological therapies have been identified to date. Urgent therapeutic alternatives are therefore needed such as neurostimulation techniques. The purpose of this review is to describe and discuss studies that have evaluated the safety and efficacy of these techniques for the treatment of cocaine dependence. METHODS: The electronic literature on repetitive transcranial magnetic stimulation, theta-burst stimulation, deep transcranial magnetic stimulation, transcranial direct current stimulation, magnetic seizure therapy, electroconvulsive therapy, cranial electro-stimulation, and deep brain stimulation in the treatment of cocaine addiction were reviewed...
August 10, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/28822238/the-environmental-injustice-of-beauty-framing-chemical%C3%A2-exposures-from-beauty-products-as-a-health%C3%A2-disparities-concern
#8
Ami R Zota, Bhavna Shamasunder
The obstetrics-gynecology community has issued a call to action to prevent toxic environmental chemical exposures and their threats to healthy human reproduction. Recent committee opinions recognize that vulnerable and underserved women may be impacted disproportionately by environmental chemical exposures and recommend that reproductive health professionals champion policies that secure environmental justice. Beauty product use is an understudied source of environmental chemical exposures. Beauty products can include reproductive and developmental toxicants such as phthalates and heavy metals; however, disclosure requirements are limited and inconsistent...
August 14, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28822233/obese-fathers-lead-to-an-altered-metabolism-and-obesity-in-their-children-in-adulthood-review-of-experimental-and-human-studies
#9
REVIEW
Fernanda Ornellas, Priscila V Carapeto, Carlos A Mandarim-de-Lacerda, Marcia B Aguila
OBJECTIVE: To discuss the recent literature on paternal obesity, focusing on the possible mechanisms of transmission of the phenotypes from the father to the children. SOURCES: A non-systematic review in the PubMed database found few publications in which paternal obesity was implicated in the adverse transmission of characteristics to offspring. Specific articles on epigenetics were also evaluated. As the subject is recent and still controversial, all articles were considered regardless of year of publication...
August 16, 2017: Jornal de Pediatria
https://www.readbyqxmd.com/read/28821637/ensuring-due-process-in-the-iacuc-and-animal-welfare-setting-considerations-in-developing-noncompliance-policies-and-procedures-for-institutional-animal-care-and-use-committees-and-institutional-officials
#10
REVIEW
Barbara C Hansen, Sylvia Gografe, Stacy Pritt, Kai-Lin Catherine Jen, Camille A McWhirter, Susan M Barman, Anthony Comuzzie, Molly Greene, Justin A McNulty, Daniel Eugene Michele, Naz Moaddab, Randall J Nelson, Karen Norris, Karen D Uray, Ron Banks, Karin N Westlund, Bill J Yates, Jerald Silverman, Kenneth D Hansen, Barbara Redman
Every institution that is involved in research with animals is expected to have in place policies and procedures for the management of allegations of noncompliance with the Animal Welfare Act and the U.S. Public Health Service Policy on the Humane Care and Use of Laboratory Animals. We present here a model set of recommendations for institutional animal care and use committees and institutional officials to ensure appropriate consideration of allegations of noncompliance with federal Animal Welfare Act regulations that carry a significant risk or specific threat to animal welfare...
August 15, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28821546/a-supervised-statistical-learning-approach-for-accurate-legionella-pneumophila-source-attribution-during-outbreaks
#11
Andrew H Buultjens, Kyra Y L Chua, Sarah L Baines, Jason Kwong, Wei Gao, Zoe Cutcher, Stuart Adcock, Susan Ballard, Mark B Schultz, Takehiro Tomita, Nela Subasinghe, Glen P Carter, Sacha J Pidot, Lucinda Franklin, Torsten Seemann, Anders Gonçalves Da Silva, Benjamin P Howden, Timothy P Stinear
Public health agencies are increasingly relying on genomics during Legionnaires' disease investigations. However, the causative bacterium (Legionella pneumophila) has an unusual population structure with extreme temporal and spatial genome sequence conservation. Furthermore, Legionnaires' disease outbreaks can be caused by multiple L. pneumophila genotypes in a single source. These factors can confound cluster identification using standard phylogenomic methods. Here, we show that a statistical learning approach based onL...
August 18, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28821528/post-traumatic-stress-disorder-in-adult-victims-of-cluster-munitions-in-lebanon-a-10-year-longitudinal-study
#12
Jawad Fares, Souheil Gebeily, Mohamad Saad, Hayat Harati, Sanaa Nabha, Najwane Said, Mohamad Kanso, Ronza Abdel Rassoul, Youssef Fares
OBJECTIVE: This study aims to explore the short-term and long-term prevalence and effects of post-traumatic stress disorder (PTSD) among victims of cluster munitions. DESIGN AND SETTING: A prospective 10-year longitudinal study that took place in Lebanon. PARTICIPANTS: Two-hundred-and-forty-four Lebanese civilian victims of submunition blasts, who were injured in 2006 and were over 18 years old, were interviewed. Included were participants who had been diagnosed with PTSD according to the Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5) and the PTSD Checklist - Civilian Version in 2006...
August 18, 2017: BMJ Open
https://www.readbyqxmd.com/read/28821510/social-and-somatic-determinants-of-underweight-overweight-and-obesity-at-5-years-of-age-a-norwegian-regional-cohort-study
#13
Hilde Mjell Donkor, Jacob Holter Grundt, Pétur Benedikt Júlíusson, Geir Egil Eide, Jørgen Hurum, Robert Bjerknes, Trond Markestad
OBJECTIVE: To identify associations between the weight groups underweight (UW), overweight (OW) and obesity (OB) at 5 years of age and exposures related to pregnancy, anthropometric measures at birth, sociodemographic factors, and family health, anthropometric measures and habits. DESIGN: Regional cohort study. SETTING: Oppland County, Norway. METHODS: Pregnancy data were obtained from a prospective perinatal register for children born in the county, and weight and height were measured by midwives at birth and by public health nurses at 5 years...
August 18, 2017: BMJ Open
https://www.readbyqxmd.com/read/28821507/social-capital-neighbourhood-characteristics-and-utilisation-of-local-public-health-services-among-domestic-migrants-in-china-a-cross-sectional-study
#14
Zhiyuan Hou, Senlin Lin, Donglan Zhang
OBJECTIVES: We examined the association between structural social capital and public health services use, and explored the modifiable effect of neighbourhood factors on this association among domestic migrants in China. METHODS: Data were from a 2014 nationally representative cross-sectional sample of domestic migrants aged 15-59 years in China. Survey-weighted logistic regression models were applied to assess the association between structural social capital, measured by participation in social organisations and social activities, and use of public health services...
August 18, 2017: BMJ Open
https://www.readbyqxmd.com/read/28821331/nontuberculous-mycobacterium-infections-associated-with-heater-cooler-devices
#15
Keith B Allen, David D Yuh, Suzanne B Schwartz, Richard A Lange, Richard Hopkins, Kelly Bauer, Julia A Marders, Jose Delgado Donayre, Nicole Milligan, Catherine Wentz
BACKGROUND: Disseminated nontuberculous mycobacterium infections have occurred following surgical procedures involving extracorporeal circulation; contaminated water from heater-cooler devices (HCDs) has been implicated as the source. The purpose of this review was to evaluate the public health concern and to educate physicians who care for this patient population. METHODS: The Food and Drug Administration Medical Device Reporting (MDR) database was queried for reports received between January 2010 and August 2016 for patient infections and device contaminations associated with the use of HCDs...
August 16, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28821263/protocol-for-a-scoping-review-to-map-evidence-from-randomised-controlled-trials-on-paediatric-eye-disease-to-disease-burden
#16
Lucinda J Teoh, Ameenat L Solebo, Jugnoo S Rahi
BACKGROUND: Currently, about 2 per 1000 children in the industrialised world are severely visually impaired or blind (SVI/BL) due to diverse uncommon conditions that are usually present from early infancy. The impact of SVI/BL is lifelong and life-changing. Thus, children are a priority in the WHO-led global initiative against avoidable blindness. The aim of this scoping review is to assess the current evidence base on interventions to prevent or treat the major causes of childhood SVI/BL, specifically the degree of alignment between robust interventional research (RCTs) and the burden (relative frequency) of the key causative disorders, identifying gaps in the evidence base for tackling childhood blindness...
August 18, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28821230/seroprevalence-of-herpes-simplex-virus-type-2-hsv-2-among-pregnant-women-who-participated-in-a-national-hiv-surveillance-activity-in-haiti
#17
Jean Wysler Domercant, Frantz Jean Louis, Erin Hulland, Mark Griswold, Jocelyne Andre-Alboth, Tun Ye, Barbara J Marston
BACKGROUND: Herpes simplex virus type 2 (HSV-2), one the most common causes of genital ulcers, appears to increase both the risk of HIV acquisition and HIV transmission. HSV-2/HIV co-infection among pregnant women may increase the risk of perinatal transmission of HIV. This study describes rates of HSV-2 among pregnant women in Haiti and HSV-2 test performance in this population. METHODS: Unlinked residual serum specimens from the 2012 National HIV and Syphilis Sentinel Surveillance Survey among pregnant women in Haiti were tested using two commercial kits (Focus HerpeSelect, Kalon) for HSV-2 antibodies...
August 18, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28820909/dose-of-physical-activity-physical-functioning-and-disability-risk-in-mobility-limited-older-adults-results-from-the-life-study-randomized-trial
#18
Roger A Fielding, Jack M Guralnik, Abby C King, Marco Pahor, Mary M McDermott, Catrine Tudor-Locke, Todd M Manini, Nancy W Glynn, Anthony P Marsh, Robert S Axtell, Fang-Chi Hsu, W Jack Rejeski
Understanding the minimal dose of physical activity required to achieve improvement in physical functioning and reductions in disability risk is necessary to inform public health recommendations. To examine the effect of physical activity dose on changes in physical functioning and the onset of major mobility disability in The Lifestyle Interventions and Independence for Elders (LIFE) Study. We conducted a multicenter single masked randomized controlled trial that enrolled participants in 2010 and 2011 and followed them for an average of 2...
2017: PloS One
https://www.readbyqxmd.com/read/28820902/from-hospitalization-records-to-surveillance-the-use-of-local-patient-profiles-to-characterize-cholera-in-vellore-india
#19
Melissa S Cruz, Tania M AlarconFalconi, Meghan A Hartwick, Aishwarya Venkat, Hanna Y Ehrlich, Shalini Anandan, Honorine D Ward, Balaji Veeraraghavan, Elena N Naumova
Despite availability of high quality medical records, health care systems often do not have the resources or tools to utilize these data efficiently. Yet, hospital-based, laboratory-confirmed records may pave the way for building reliable surveillance systems capable of monitoring temporal trends of emerging infections. In this communication, we present a new tool to compress and visualize medical records with a local population profile (LPP) approach, which transforms information into statistically comparable patterns...
2017: PloS One
https://www.readbyqxmd.com/read/28820881/vector-competence-of-populations-of-aedes-aegypti-from-three-distinct-cities-in-kenya-for-chikungunya-virus
#20
Sheila B Agha, Edith Chepkorir, Francis Mulwa, Caroline Tigoi, Samwel Arum, Milehna M Guarido, Peris Ambala, Betty Chelangat, Joel Lutomiah, David P Tchouassi, Michael J Turell, Rosemary Sang
BACKGROUND: In April, 2004, chikungunya virus (CHIKV) re-emerged in Kenya and eventually spread to the islands in the Indian Ocean basin, South-East Asia, and the Americas. The virus, which is often associated with high levels of viremia in humans, is mostly transmitted by the urban vector, Aedes aegypti. The expansion of CHIKV presents a public health challenge both locally and internationally. In this study, we investigated the ability of Ae. aegypti mosquitoes from three distinct cities in Kenya; Mombasa (outbreak prone), Kisumu, and Nairobi (no documented outbreak) to transmit CHIKV...
August 18, 2017: PLoS Neglected Tropical Diseases
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