Celina Dubin, Jacob W Glickman, Ester Del Duca, Sumanth Chennareddy, Joseph Han, Dante Dahabreh, Yeriel D Estrada, Ning Zhang, Grace W Kimmel, Giselle Singer, Mashkura Chowdhury, Andrew Y Zheng, Michael Angelov, Jesús Gay-Mimbrera, Juan Ruano Ruiz, James G Krueger, Ana B Pavel, Emma Guttman-Yassky
BACKGROUND: Frontal fibrosing alopecia (FFA) is a progressive, scarring alopecia of the frontotemporal scalp that poses a substantial burden on quality of life. Large-scale global profiling of FFA is lacking, preventing the development of effective therapeutics. OBJECTIVE: To characterize FFA compared to normal and alopecia areata using broad molecular profiling and to identify biomarkers linked to disease severity. METHODS: This cross-sectional study assessed 33,118 genes in scalp using RNA sequencing and 350 proteins in serum using OLINK high-throughput proteomics...
March 2022: Journal of the American Academy of Dermatology