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https://www.readbyqxmd.com/read/28441584/the-efficacy-and-safety-of-aripiprazole-for-tic-disorders-in-children-and-adolescents-a-systematic-review-and-meta-analysis
#1
Shuai Wang, Yan-Zhao Wei, Jian-Hong Yang, Yu-Ming Zhou, Yu-Hang Cheng, Chao Yang, Yi Zheng
The aims are to evaluate the efficacy and safety of aripiprazole for tic disorders (TDs) in children and adolescents. We searched PubMed, Embase, PsychINFO, Cochrane database as well as Chinese databases of CNKI, VIP, CBM and Wanfang from the database inception to October 2016, and 17 full-text studies (N=1305) were included in our article. The meta-analysis of 10 studies (N=817) showed that there was no significant difference in the reduction of total YGTSS score between aripiprazole and other drugs, and meta-analysis of 7 studies (n=324) which used tic symptom control ≧30% as outcome measure showed that there was no significant difference between aripiprazole and other treatments...
April 6, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28441573/the-role-of-negative-affect-and-message-credibility-in-perceived-effectiveness-of-smokeless-tobacco-health-warning-labels-in-navi-mumbai-india-and-dhaka-bangladesh-a-moderated-mediation-analysis
#2
Seema Mutti-Packer, Jessica L Reid, James F Thrasher, Daniel Romer, Geoffrey T Fong, Prakash C Gupta, Mangesh S Pednekar, Nigar Nargis, David Hammond
OBJECTIVE: There is strong evidence showing that pictorial health warnings are more effective than text-only warnings. However, much of this evidence comes from high-income countries and is limited to cigarette packaging. Moreover, few studies have identified mechanisms that might explain the impact of warnings. METHODS: The current study examined the potential mediating role of negative affect and the moderating influence of message credibility in perceived effectiveness of smokeless tobacco warnings in two low- and middle-income countries (LMICs)...
April 4, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/28441452/systematic-review-finds-that-study-data-not-published-in-full-text-articles-have-unclear-impact-on-meta-analyses-results-in-medical-research
#3
Christine M Schmucker, Anette Blümle, Lisa K Schell, Guido Schwarzer, Patrick Oeller, Laura Cabrera, Erik von Elm, Matthias Briel, Joerg J Meerpohl
BACKGROUND: A meta-analysis as part of a systematic review aims to provide a thorough, comprehensive and unbiased statistical summary of data from the literature. However, relevant study results could be missing from a meta-analysis because of selective publication and inadequate dissemination. If missing outcome data differ systematically from published ones, a meta-analysis will be biased with an inaccurate assessment of the intervention effect. As part of the EU-funded OPEN project (www...
2017: PloS One
https://www.readbyqxmd.com/read/28441381/text-message-reminders-in-colorectal-cancer-screening-triccs-a-randomised-controlled-trial
#4
Yasemin Hirst, Hanna Skrobanski, Robert S Kerrison, Lindsay C Kobayashi, Nicholas Counsell, Natasha Djedovic, Josephine Ruwende, Mark Stewart, Christian von Wagner
BACKGROUND: We investigated the effectiveness of a text-message reminder to improve uptake of the English Bowel Cancer Screening programme in London. METHODS: We performed a randomised controlled trial across 141 general practices in London. Eight thousand two hundred sixty-nine screening-eligible adults (aged 60-74 years) were randomised in a 1 : 1 ratio to receive either a text-message reminder (n=4134) or no text-message reminder (n=4135) if they had not returned their faecal occult blood test kit within 8 weeks of initial invitation...
April 25, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28440958/readiness-for-hospital-discharge-a-concept-analysis
#5
Eileen Catherine Galvin, Teresa Wills, Alice Coffey
AIM: To report on an analysis on the concept of 'readiness for hospital discharge'. BACKGROUND: No uniform operational definition of 'readiness for hospital discharge' exists in the literature, therefore a concept analysis is required to clarify the concept and identify an up to date understanding of readiness for hospital discharge. Clarity of the concept will identify all uses of the concept; provide conceptual clarity, an operational definition and direction for further research...
April 25, 2017: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/28439765/-formula-see-text-catalyzed-formula-see-text-annulation-between-3-oxirane-indolin-2-ones-and-nitrones-to-construct-spiro-1-4-2-dioxazinan-oxindoles
#6
Jingmiao Yu, Chun Cai
An efficient and mild procedure for the synthesis of spiro[1,4,2-dioxazinan]oxindoles has been achieved in high yields by [Formula: see text]-catalyzed annulation of 3-oxirane-indolin-2-ones and nitrones. This catalytic protocol demonstrates that the reaction could tolerate a variety of functional groups and provides convenient access to new structural motifs in good to excellent yields. Moreover, this method featured relatively short reaction time and easy operation.
April 24, 2017: Molecular Diversity
https://www.readbyqxmd.com/read/28439636/kinematic-alignment-is-a-possible-alternative-to-mechanical-alignment-in-total-knee-arthroplasty
#7
Yong Seuk Lee, Stephen M Howell, Ye-Yeon Won, O-Sung Lee, Seung Hoon Lee, Hamed Vahedi, Seow Hui Teo
PURPOSE: A systematic review was conducted to answer the following questions: (1) Does kinematically aligned (KA) total knee arthroplasty (TKA) achieve clinical outcomes comparable to those of mechanically aligned (MA) TKA? (2) How do the limb, knee, and component alignments differ between KA and MA TKA? (3) How is joint line orientation angle (JLOA) changed from the native knee in KA TKA compared to that in MA TKA? METHODS: Nine full-text articles in English that reported the clinical and radiological outcomes of KA TKA were included...
April 24, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28439524/brainsegnet-a-convolutional-neural-network-architecture-for-automated-segmentation-of-human-brain-structures
#8
Raghav Mehta, Aabhas Majumdar, Jayanthi Sivaswamy
Automated segmentation of cortical and noncortical human brain structures has been hitherto approached using nonrigid registration followed by label fusion. We propose an alternative approach for this using a convolutional neural network (CNN) which classifies a voxel into one of many structures. Four different kinds of two-dimensional and three-dimensional intensity patches are extracted for each voxel, providing local and global (context) information to the CNN. The proposed approach is evaluated on five different publicly available datasets which differ in the number of labels per volume...
April 2017: Journal of Medical Imaging
https://www.readbyqxmd.com/read/28439522/automatic-image-quality-assessment-and-measurement-of-fetal-head-in-two-dimensional-ultrasound-image
#9
Lei Zhang, Nicholas J Dudley, Tryphon Lambrou, Nigel Allinson, Xujiong Ye
Owing to the inconsistent image quality existing in routine obstetric ultrasound (US) scans that leads to a large intraobserver and interobserver variability, the aim of this study is to develop a quality-assured, fully automated US fetal head measurement system. A texton-based fetal head segmentation is used as a prerequisite step to obtain the head region. Textons are calculated using a filter bank designed specific for US fetal head structure. Both shape- and anatomic-based features calculated from the segmented head region are then fed into a random forest classifier to determine the quality of the image (e...
April 2017: Journal of Medical Imaging
https://www.readbyqxmd.com/read/28439520/relationship-between-relative-cerebral-blood-flow-relative-cerebral-blood-volume-and-relative-cerebral-metabolic-rate-of-oxygen-in-the-preterm-neonatal-brain
#10
Mina Nourhashemi, Guy Kongolo, Mahdi Mahmoudzadeh, Sabrina Goudjil, Fabrice Wallois
The mechanisms responsible for coupling between relative cerebral blood flow (rCBF), relative cerebral blood volume (rCBV), and relative cerebral metabolic rate of oxygen ([Formula: see text]), an important function of the microcirculation in preterm infants, remain unclear. Identification of a causal relationship between rCBF-rCBV and [Formula: see text] in preterms may, therefore, help to elucidate the principles of cortical hemodynamics during development. We simultaneously recorded rCBF and rCBV and estimated [Formula: see text] by two independent acquisition systems: diffuse correlation spectroscopy and near-infrared spectroscopy, respectively, in 10 preterms aged between 28 and 35 weeks of gestational age...
April 2017: Neurophotonics
https://www.readbyqxmd.com/read/28439519/structured-illumination-diffuse-optical-tomography-for-noninvasive-functional-neuroimaging-in-mice
#11
Matthew D Reisman, Zachary E Markow, Adam Q Bauer, Joseph P Culver
Optical intrinsic signal (OIS) imaging has been a powerful tool for capturing functional brain hemodynamics in rodents. Recent wide field-of-view implementations of OIS have provided efficient maps of functional connectivity from spontaneous brain activity in mice. However, OIS requires scalp retraction and is limited to superficial cortical tissues. Diffuse optical tomography (DOT) techniques provide noninvasive imaging, but previous DOT systems for rodent neuroimaging have been limited either by sparse spatial sampling or by slow speed...
April 2017: Neurophotonics
https://www.readbyqxmd.com/read/28439023/superconductivity-and-non-fermi-liquid-behavior-near-a-nematic-quantum-critical-point
#12
Samuel Lederer, Yoni Schattner, Erez Berg, Steven A Kivelson
Using determinantal quantum Monte Carlo, we compute the properties of a lattice model with spin [Formula: see text] itinerant electrons tuned through a quantum phase transition to an Ising nematic phase. The nematic fluctuations induce superconductivity with a broad dome in the superconducting [Formula: see text] enclosing the nematic quantum critical point. For temperatures above [Formula: see text], we see strikingly non-Fermi liquid behavior, including a "nodal-antinodal dichotomy" reminiscent of that seen in several transition metal oxides...
April 24, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28439020/mathematical-model-of-chronic-pancreatitis
#13
Wenrui Hao, Hannah M Komar, Phil A Hart, Darwin L Conwell, Gregory B Lesinski, Avner Friedman
Chronic pancreatitis (CP) is a progressive inflammatory disease of the pancreas, leading to its fibrotic destruction. There are currently no drugs that can stop or slow the progression of the disease. The etiology of the disease is multifactorial, whereas recurrent attacks of acute pancreatitis are thought to precede the development of CP. A better understanding of the pathology of CP is needed to facilitate improved diagnosis and treatment strategies for this disease. The present paper develops a mathematical model of CP based on a dynamic network that includes macrophages, pancreatic stellate cells, and prominent cytokines that are present at high levels in the CP microenvironment...
April 24, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28438759/palliative-care-clinicians-knowledge-of-the-law-regarding-the-use-of-the-deprivation-of-liberty-safeguards-dols
#14
Caroline Barry, Anna Spathis, Sarah Treaddell, Sally Carding, Stephen Barclay
OBJECTIVES: To examine palliative care clinicians' level of knowledge of the law regarding the use of the Deprivation of Liberty Safeguards (DoLS). METHODS: Regional postal survey of palliative care clinicians working in hospices in the East of England, undertaken in April 2015. Clinicians' level of knowledge was assessed by their response to 7 factual questions. Data regarding self-reported levels of confidence in applying the Safeguards was collected, alongside information regarding the number of times they had used DoLS in practice...
April 24, 2017: BMJ Supportive & Palliative Care
https://www.readbyqxmd.com/read/28438728/designing-patient-centered-text-messaging-interventions-for-increasing-physical-activity-among-participants-with-type-2-diabetes-qualitative-results-from-the-text-to-move-intervention
#15
Gabrielle N Horner, Stephen Agboola, Kamal Jethwani, Aswita Tan-McGrory, Lenny Lopez
BACKGROUND: Type 2 diabetes mellitus (T2DM) is a disease affecting approximately 29.1 million people in the United States, and an additional 86 million adults have prediabetes. Diabetes self-management education, a complex health intervention composed of 7 behaviors, is effective at improving self-care behaviors and glycemic control. Studies have employed text messages for education, reminders, and motivational messaging that can serve as "cues to action," aiming to improve glucose monitoring, self-care behaviors, appointment attendance, and medication adherence...
April 24, 2017: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/28438726/analyzing-unstructured-communication-in-a-computer-mediated-environment-for-adults-with-type-2-diabetes-a-research-protocol
#16
Allison A Lewinski, Ruth A Anderson, Allison A Vorderstrasse, Edwin B Fisher, Wei Pan, Constance M Johnson
BACKGROUND: Individuals with type 2 diabetes have an increased risk for comorbidities such as heart disease, lower limb amputations, stroke, and renal failure. Multiple factors influence development of complications in a person living with type 2 diabetes; however, an individual's self-management behaviors may delay the onset of, or lessen the severity of, these complications. Social support provides personal, informal advice and knowledge that helps individuals initiate and sustain self-management and adherence...
April 24, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28438725/analyzing-and-predicting-user-participations-in-online-health-communities-a-social-support-perspective
#17
Xi Wang, Kang Zhao, Nick Street
BACKGROUND: Online health communities (OHCs) have become a major source of social support for people with health problems. Members of OHCs interact online with similar peers to seek, receive, and provide different types of social support, such as informational support, emotional support, and companionship. As active participations in an OHC are beneficial to both the OHC and its users, it is important to understand factors related to users' participations and predict user churn for user retention efforts...
April 24, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28438666/how-to-choose-the-right-mr-sequence-for-your-research-question-at-7-t-and-above
#18
José P Marques, David G Norris
The choice of a pulse sequence at ultra-high field can be influenced by a number of considerations and constraints that are not always the same as those at lower fields. Foremost amongst these is of course the information required and the time available, but considerations of static main field- and transmit field- inhomogeneities as well as power deposition can also play an important role. In this review we first briefly examine the characteristics of high field MRI, and then describe the performance and constraints relevant to the major imaging readouts, and their implementation with parallel imaging techniques...
April 21, 2017: NeuroImage
https://www.readbyqxmd.com/read/28438274/the-effectiveness-of-acupuncture-acupressure-and-chiropractic-interventions-on-treatment-of-chronic-nonspecific-low-back-pain-in-iran-a-systematic-review-and-meta-analysis
#19
REVIEW
Mohsen Yeganeh, Hamid Reza Baradaran, Mostafa Qorbani, Yousef Moradi, Saeed Dastgiri
BACKGROUND: Low back pain (LBP) is one of the most common health problems in adults. The impact of LBP on the individual can cause loss of health status and function related to pain in the back. To reduce the impact of LBP on adults, drug therapy is the most frequently recommended intervention. But over the last decade, a substantial number of randomized clinical trials of non-pharmacological intervention for LBP have been published. OBJECTIVE: To determine the effectiveness of acupuncture, acupressure and chiropractic (non-pharmacological) interventions on the treatment of chronic nonspecific low back pain in Iran...
May 2017: Complementary Therapies in Clinical Practice
https://www.readbyqxmd.com/read/28438218/malaria-elimination-in-lao-pdr-the-challenges-associated-with-population-mobility
#20
REVIEW
Sengchanh Kounnavong, Deyer Gopinath, Bouasy Hongvanthong, Chanthalone Khamkong, Odai Sichanthongthip
Although the Lao People's Democratic Republic (Lao PDR) is comparatively small landlocked country with patterns of both in- and out-migration, its human migration situation has been poorly studied. This is despite all of the country's 18 provinces sharing both official and unofficial border checkpoints with neighboring countries. Economic reforms in the last decade have seen a gradual increase in the promotion of foreign investment, and main towns and transportation networks have been expanding thus offering new opportunities for livelihoods and economic activities...
April 25, 2017: Infectious Diseases of Poverty
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