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https://www.readbyqxmd.com/read/28542087/validity-of-postmortem-glycated-hemoglobin-to-determine-status-of-diabetes-mellitus-in-corneal-donors
#1
Mark C Soper, Santica M Marcovina, Caroline K Hoover, Peter M Calhoun, Kristen E McCoy, Christopher G Stoeger, Gregory A Schmidt, Baha M Arafah, Marianne O Price, Loretta B Szczotka-Flynn, Jonathan H Lass
PURPOSE: To examine the stability of postmortem glycated hemoglobin (HbA1c) measurement and its relationship to premortem glycemia. METHODS: Postmortem blood samples were obtained from 32 donors (8 known diabetic) and shipped on ice to a central laboratory to examine the stability of HbA1c measurements during the first 9 postmortem days. Thirty-nine other suspected diabetic donors underwent comparison of premortem and postmortem HbA1c measurements. RESULTS: Postmortem HbA1c measurements remained stable after 9 postmortem days (all measurements within ±0...
May 23, 2017: Cornea
https://www.readbyqxmd.com/read/28412056/biomolecules-from-olive-pruning-waste-in-sierra-m%C3%A3-gina-engaging-the-energy-transition-by-multi-actor-and-multidisciplinary-analyses
#2
Marianne Cohen, Gilles Lepesant, Farida Lamari, Clelia Bilodeau, Petra Benyei, Stéphane Angles, Julien Bouillon, Kevin Bourrand, Ramla Landoulsi, Delphine Jaboeuf, Maria Alonso-Roldán, Isidro Espadas-Tormo, Veronica Belandria, Philippe Silar, Moussa Dicko
The price volatility of fossil resources, the uncertainty of their long-term availability and the environmental, climatic and societal problems posed by their operation lead to the need of an energy transition enabling the development and utilization of other alternative and sustainable resources. Acknowledging that indirect land-use change can increase greenhouse gas emission, the European Union (EU) has reshaped its biofuel policy. It has set criteria for sustainability to ensure that the use of biofuels guarantees real carbon savings and protects biodiversity...
April 12, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28404202/hepatitis-c-treatment-as-prevention-evidence-feasibility-and-challenges
#3
REVIEW
Behzad Hajarizadeh, Jason Grebely, Marianne Martinello, Gail V Matthews, Andrew R Lloyd, Gregory J Dore
The advent of interferon-free direct-acting antiviral therapy for hepatitis C virus (HCV) infection has heightened discussion of treatment as prevention. Rapid scale-up in many settings, and the prospect of further treatment simplification have extended therapeutic optimism towards HCV elimination. However, questions remain regarding the feasability of HCV treatment as prevention, including real world efficacy of direct-acting antiviral therapy, particularly among people who inject drugs, and whether expanded treatment access will be sufficient to reduce HCV transmission...
December 2016: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28358029/genome-wide-association-study-identifies-three-novel-loci-in-fuchs-endothelial-corneal-dystrophy
#4
Natalie A Afshari, Robert P Igo, Nathan J Morris, Dwight Stambolian, Shiwani Sharma, V Lakshmi Pulagam, Steven Dunn, John F Stamler, Barbara J Truitt, Jacqueline Rimmler, Abraham Kuot, Christopher R Croasdale, Xuejun Qin, Kathryn P Burdon, S Amer Riazuddin, Richard Mills, Sonja Klebe, Mollie A Minear, Jiagang Zhao, Elmer Balajonda, George O Rosenwasser, Keith H Baratz, V Vinod Mootha, Sanjay V Patel, Simon G Gregory, Joan E Bailey-Wilson, Marianne O Price, Francis W Price, Jamie E Craig, John H Fingert, John D Gottsch, Anthony J Aldave, Gordon K Klintworth, Jonathan H Lass, Yi-Ju Li, Sudha K Iyengar
The structure of the cornea is vital to its transparency, and dystrophies that disrupt corneal organization are highly heritable. To understand the genetic aetiology of Fuchs endothelial corneal dystrophy (FECD), the most prevalent corneal disorder requiring transplantation, we conducted a genome-wide association study (GWAS) on 1,404 FECD cases and 2,564 controls of European ancestry, followed by replication and meta-analysis, for a total of 2,075 cases and 3,342 controls. We identify three novel loci meeting genome-wide significance (P<5 × 10(-8)): KANK4 rs79742895, LAMC1 rs3768617 and LINC00970/ATP1B1 rs1200114...
March 30, 2017: Nature Communications
https://www.readbyqxmd.com/read/27854208/mortality-and-causes-of-death-in-patients-with-sporadic-inclusion-body-myositis-survey-study-based-on-the-clinical-experience-of-specialists-in-australia-europe-and-the-usa
#5
Mark A Price, Victoria Barghout, Olivier Benveniste, Lisa Christopher-Stine, Alastair Corbett, Marianne de Visser, David Hilton-Jones, John T Kissel, Thomas E Lloyd, Ingrid E Lundberg, Francis Mastaglia, Tahseen Mozaffar, Merrilee Needham, Jens Schmidt, Kumaraswamy Sivakumar, Carla DeMuro, Brian S Tseng
BACKGROUND: There is a paucity of data on mortality and causes of death (CoDs) in patients with sporadic inclusion body myositis (sIBM), a rare, progressive, degenerative, inflammatory myopathy that typically affects those aged over 50 years. OBJECTIVE: Based on patient records and expertise of clinical specialists, this study used questionnaires to evaluate physicians' views on clinical characteristics of sIBM that may impact on premature mortality and CoDs in these patients...
March 3, 2016: Journal of Neuromuscular Diseases
https://www.readbyqxmd.com/read/27731950/elimination-of-erroneous-results-in-flow-cytometry-caused-by-antibody-binding-to-fc-receptors-on-human-monocytes-and-macrophages
#6
Morten N Andersen, Sinan N H Al-Karradi, Tue W Kragstrup, Marianne Hokland
Nonspecific binding of monoclonal antibodies (mAbs) to Fc-receptors on leukocytes is an important cause of background fluorescence in flow cytometry, and failing to block such nonspecific binding can lead to erroneous results. A major part of previous studies on blocking reagents for flow cytometry have been done in mice, and published results are not completely in agreement. In humans, Fc-receptors are found on most leukocytes, with highest abundance on monocytes/macrophages. Therefore, in the present study our aim was to thoroughly investigate the efficiency of different commonly used blocking reagents regarding inhibition of nonspecific binding of mouse mAbs to human peripheral blood mononuclear cells (MNCs) and monocyte-derived macrophages (MDMs)...
November 2016: Cytometry. Part A: the Journal of the International Society for Analytical Cytology
https://www.readbyqxmd.com/read/27666015/steroid-induced-ocular-hypertension-glaucoma-focus-on-pharmacogenomics-and-implications-for-precision-medicine
#7
REVIEW
M Elizabeth Fini, Stephen G Schwartz, Xiaoyi Gao, Shinwu Jeong, Nitin Patel, Tatsuo Itakura, Marianne O Price, Francis W Price, Rohit Varma, W Daniel Stamer
Elevation of intraocular pressure (IOP) due to therapeutic use of glucocorticoids is called steroid-induced ocular hypertension (SIOH); this can lead to steroid-induced glaucoma (SIG). Glucocorticoids initiate signaling cascades ultimately affecting expression of hundreds of genes; this provides the potential for a highly personalized pharmacological response. Studies attempting to define genetic risk factors were undertaken early in the history of glucocorticoid use, however scientific tools available at that time were limited and progress stalled...
January 2017: Progress in Retinal and Eye Research
https://www.readbyqxmd.com/read/27639969/existence-of-neural-crest-derived-progenitor-cells-in-normal-and-fuchs-endothelial-dystrophy-corneal-endothelium
#8
Kishore Reddy Katikireddy, Thore Schmedt, Marianne O Price, Francis W Price, Ula V Jurkunas
Human corneal endothelial cells are derived from neural crest and because of postmitotic arrest lack competence to repair cell loss from trauma, aging, and degenerative disorders such as Fuchs endothelial corneal dystrophy (FECD). Herein, we identified a rapidly proliferating subpopulation of cells from the corneal endothelium of adult normal and FECD donors that exhibited features of neural crest-derived progenitor (NCDP) cells by showing absence of senescence with passaging, propensity to form spheres, and increased colony forming efficacy compared with the primary cells...
October 2016: American Journal of Pathology
https://www.readbyqxmd.com/read/27576065/biospecimen-user-fees-global-feedback-on-a-calculator-tool
#9
Lise A M Matzke, Sindy Babinszky, Alex Slotty, Anna Meredith, Tania Castillo-Pelayo, Marianne K Henderson, Daniel Simeon-Dubach, Brent Schacter, Peter H Watson
The notion of attributing user fees to researchers for biospecimens provided by biobanks has been discussed frequently in the literature. However, the considerations around how to attribute the cost for these biospecimens and data have, until recently, not been well described. Common across most biobank disciplines are similar factors that influence user fees such as capital and operating costs, internal and external demand, and market competition. A biospecimen user fee calculator tool developed by CTRNet, a tumor biobank network, was published in 2014 and is accessible online at www...
February 2017: Biopreservation and Biobanking
https://www.readbyqxmd.com/read/27560030/prevention-and-management-of-pupil-block-after-descemet-membrane-endothelial-keratoplasty
#10
Andres Gonzalez, Francis W Price, Marianne O Price, Matthew T Feng
PURPOSE: To assess frequency, associations, and outcomes of full air fill after Descemet membrane endothelial keratoplasty (DMEK). METHODS: This retrospective study reviewed 368 consecutive DMEK cases performed to treat Fuchs dystrophy, bullous keratopathy, or failed keratoplasty. Primary outcomes were air bubble status, intraocular pressure, and incidence of pupil block and air reinjection. RESULTS: Using an air management algorithm, slit-lamp assessment 1 hour after DMEK identified complete air fill in 80/368 eyes (22%)...
November 2016: Cornea
https://www.readbyqxmd.com/read/27208981/three-year-longitudinal-survey-comparing-visual-satisfaction-with-lasik-and-contact-lenses
#11
Marianne O Price, David A Price, Frank A Bucci, Daniel S Durrie, William I Bond, Francis W Price
PURPOSE: To assess patient satisfaction and perceived outcomes with different methods of refractive error correction through annual surveys administered over a 3-year period. DESIGN: Prospective, longitudinal, parallel-group, multicenter survey. PARTICIPANTS: A total of 1800 subjects, aged 18 to 60 years, who had LASIK or continued using contact lenses. METHODS: Twenty sites across the United States enrolled subjects who completed a study-specific baseline survey during a contact lens examination or while being evaluated as a candidate for LASIK...
August 2016: Ophthalmology
https://www.readbyqxmd.com/read/27158810/effect-of-descemet-membrane-endothelial-keratoplasty-on-color-vision-in-patients-with-fuchs-dystrophy
#12
David A Price, Marianne O Price, Amanda Lopez, Francis W Price
PURPOSE: To assess changes in color discernment after Descemet membrane endothelial keratoplasty (DMEK) in patients with Fuchs endothelial corneal dystrophy (FECD). METHODS: In this prospective, single-center study, the study group was composed of 26 patients with FECD, aged 46 to 85 years, who underwent DMEK as a single surgical procedure; 24 (92%) had pseudophakic and 2 (8%) had phakic eyes. The patients completed a computerized Farnsworth-Munsell 100-hue color vision test before and 1 month after DMEK...
August 2016: Cornea
https://www.readbyqxmd.com/read/27108095/descemet-stripping-endothelial-keratoplasty-ten-year-endothelial-cell-loss-compared-with-penetrating-keratoplasty
#13
COMPARATIVE STUDY
Marianne O Price, Peter Calhoun, Craig Kollman, Francis W Price, Jonathan H Lass
PURPOSE: To assess endothelial cell density (ECD) and model 10-year cell loss after Descemet stripping endothelial keratoplasty (DSEK), and to compare with results after penetrating keratoplasty (PK) performed for the same indications in the Cornea Donor Study (CDS). DESIGN: Retrospective, longitudinal study. PARTICIPANTS: Five hundred ninety DSEK recipients, 21 to 96 years of age, treated for Fuchs' dystrophy (n = 498; 84%), pseudophakic or aphakic corneal edema (n = 89; 15%), or other endothelial dysfunction (n = 3; <1%)...
July 2016: Ophthalmology
https://www.readbyqxmd.com/read/27061020/aflibercept-vs-ranibizumab-cost-effectiveness-of-treatment-for-wet-age-related-macular-degeneration-in-sweden
#14
COMPARATIVE STUDY
Hemangi R Panchmatia, Karen M Clements, Erin Hulbert, Marianne Eriksson, Kim Wittrup-Jensen, Jonas Nilsson, Milton C Weinstein
PURPOSE: Monthly dosing with ranibizumab (RBZ) is needed to achieve maximal visual gains in patients with neovascular ('wet') age-related macular degeneration (wAMD). In Sweden, dosing is performed as needed (RBZ PRN), resulting in suboptimal efficacy. Intravitreal aflibercept (IVT-AFL) every 2 months after three initial monthly doses was clinically equivalent to RBZ monthly dosing (RBZ q4) in wAMD clinical trials. We assessed the cost-effectiveness of IVT-AFL versus RBZ q4 and RBZ PRN in Sweden...
August 2016: Acta Ophthalmologica
https://www.readbyqxmd.com/read/26983976/descemet-s-membrane-endothelial-keratoplasty-risk-of-immunologic-rejection-episodes-after-discontinuing-topical-corticosteroids
#15
Marianne O Price, Amanda Scanameo, Matthew T Feng, Francis W Price
PURPOSE: To assess the risk of immunologic rejection episodes if topical corticosteroids are discontinued 1 year after Descemet's membrane endothelial keratoplasty (DMEK) compared with continued once-per-day use. DESIGN: Prospective, longitudinal, parallel-group study. PARTICIPANTS: A total of 400 eyes of 259 DMEK recipients, aged 23 to 90 years. METHODS: Patients were enrolled 1 year after DMEK and allowed to choose whether to stop or continue once-daily topical corticosteroids to maximize compliance...
June 2016: Ophthalmology
https://www.readbyqxmd.com/read/26780316/an-evaluation-of-lysyl-oxidase-derived-cross-linking-in-keratoconus-by-liquid-chromatography-mass-spectrometry
#16
Anna Takaoka, Natasha Babar, Julia Hogan, MiJung Kim, Marianne O Price, Francis W Price, Stephen L Trokel, David C Paik
PURPOSE: Current literature contains scant information regarding the extent of enzymatic collagen cross-linking in the keratoconus (KC) cornea. The aim of the present study was to examine levels of enzymatic lysyl oxidase-derived cross-links in stromal collagen in KC tissue, and to correlate the cross-link levels with collagen fibril stability as determined by thermal denaturation temperature (Tm). METHODS: Surgical KC samples (n = 17) and Eye-Bank control (n = 11) corneas of age 18 to 68 years were analyzed...
January 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/26248040/memantine-associated-corneal-endothelial-dysfunction
#17
Matthew T Feng, Francis W Price, Yuri McKee, Marianne O Price
No abstract text is available yet for this article.
October 2015: JAMA Ophthalmology
https://www.readbyqxmd.com/read/26114828/evolution-of-endothelial-keratoplasty-where-are-we-headed
#18
REVIEW
Francis W Price, Matthew T Feng, Marianne O Price
In less than 10 years, the proportion of endothelial keratoplasty (EK) procedures has increased from less than 5% of the corneal grafts in the United States to over half. EK has made corneal grafts safer and provides better and more predictable visual results than standard full-thickness penetrating keratoplasty. Descemet membrane endothelial keratoplasty in particular has dramatically reduced the risk of rejection, allowing reduction in topical corticosteroid use, resulting in a lower incidence of steroid-induced intraocular pressure elevation...
October 2015: Cornea
https://www.readbyqxmd.com/read/26096520/refractive-outcomes-of-descemet-membrane-endothelial-keratoplasty-triple-procedures-combined-with-cataract-surgery
#19
Evan D Schoenberg, Francis W Price, Jalee Miller, Yuri McKee, Marianne O Price
PURPOSE: To describe the refractive outcomes of triple Descemet membrane endothelial keratoplasty (DMEK). DESIGN: Retrospective case series. METHODS: The study included patients with Fuchs endothelial dystrophy and cataract without coincident pathology. RESULTS: Outcomes of 108 sequential triple DMEK procedures were evaluated. With a mean follow-up of 11.9 months, the median corrected distance visual acuity (CDVA) was 20/20 (range 20/15 to 20/40) and the median uncorrected distance visual acuity in eyes with a distance target (n = 84) was 20/40 (range 20/20 to 20/200)...
June 2015: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/26068612/a-year-of-cornea-in-review-2013
#20
REVIEW
Juan G Arbelaez, Matthew T Feng, Tomas J Pena, Marianne O Price, Francis W Price
PURPOSE: The goal of this study was to provide an update of significant corneal literature published in 2013. DESIGN: This study is a systematic literature review. METHODS: We conducted a systematic review of the English-language literature published from January 1, 2013, to December 31, 2013, using the following PubMed search and Medical Subject Headings terms: cornea transplantation, keratoplasty, Descemet membrane endothelial keratoplasty, Descemet stripping endothelial keratoplasty, cross linking, pre-Descemet's layer, Rho-associated kinase, keratoprosthesis, infectious keratitis, corneal dystrophy, corneal astigmatism, and keratoconus...
January 2015: Asia-Pacific Journal of Ophthalmology
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