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https://www.readbyqxmd.com/read/28722060/poly-amino-acid-polyester-graft-copolymer-nanoparticles-for-the-acid-mediated-release-of-doxorubicin
#1
Daniel J Price, Mthulisi Khuphe, Robert P W Davies, James R McLaughlan, Nicola Ingram, Paul D Thornton
Biodegradable polymers have emerged as highly effective drug delivery vehicles. We combine N-carboxyanhydride and O-carboxyanhydride ring opening polymerisations to synthesise a poly(amino acid)-polyester graft copolymer capable of encapsulating, and subsequently releasing doxorubicin via acid-mediated hydrolysis. Consequently, the nanoparticles detailed are extremely promising vehicles for the controlled delivery of chemotherapeutic agents.
July 19, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28669475/editorial-commentary-robbing-peter-to-pay-paul-is-osteochondral-autograft-transplantation-of-the-elbow-capitellum-worth-the-price
#2
EDITORIAL
Paul E Caldwell
Osteochondritis dissecans (OCD) of the elbow capitellum is a common disorder that causes pain and functional limitation in the athletic adolescent elbow. Many surgical options have been proposed over the years, but none has stood the test of time. A recent well-written systematic review highlights the treatment options and recognizes a growing trend toward osteochondral allograft transplantation as the ideal solution. Unfortunately, the study also underscores the paucity of evidence on which we base our treatment decisions for OCD of the elbow in the young athlete...
July 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/28668459/are-outcomes-of-thoracoabdominal-aortic-aneurysm-repair-different-in-men-versus-women-a-propensity-matched-comparison
#3
Konstantinos Spiliotopoulos, Matt D Price, Hiruni S Amarasekara, Susan Y Green, Qianzi Zhang, Ourania Preventza, Joseph S Coselli, Scott A LeMaire
OBJECTIVE: Women fare worse than men after many cardiovascular operations, including coronary artery bypass grafting and valve surgery. We sought to determine whether sex affects outcomes after open thoracoabdominal aortic aneurysm repair. METHODS: We evaluated data on 3353 consecutive patients (1281 women, 38.2%) who underwent open thoracoabdominal aortic aneurysm repair between October 1986 and July 2015. We compared preoperative characteristics, surgical variables, and outcomes between men and women in the overall group...
June 3, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28577670/cangrelor-reduces-the-risk-of-ischemic-complications-in-patients-with-single-vessel-and-multi-vessel-disease-undergoing-percutaneous-coronary-intervention-insights-from-the-champion-phoenix-trial
#4
Freddy Abnousi, Vandana Sundaram, Celina M Yong, Jayne Prats, Efthymios N Deliargyris, Gregg W Stone, Christian W Hamm, Philippe Gabriel Steg, Charles Michael Gibson, Harvey D White, Matthew J Price, Philippe Généreux, Manisha Desai, Lingyao Yang, Victoria Y Ding, Robert A Harrington, Deepak L Bhatt, Kenneth W Mahaffey
OBJECTIVE: To examine the safety and efficacy of cangrelor in patients with single-vessel disease (SVD) and multi-vessel disease (MVD). BACKGROUND: Cangrelor, an intravenous, rapidly acting P2Y12 inhibitor, is superior to clopidogrel in reducing ischemic events among patients receiving percutaneous coronary intervention (PCI). METHODS: We studied a modified intention to treat population of patients with SVD and MVD from the CHAMPION PHOENIX trial...
June 2017: American Heart Journal
https://www.readbyqxmd.com/read/28570440/successful-reinnervation-of-the-diaphragm-after-intercostal-to-phrenic-nerve-neurotization-in-patients-with-high-spinal-cord-injury
#5
Kulvir S Nandra, Martin Harari, Thea P Price, Patrick J Greaney, Michael S Weinstein
OBJECTIVE: Our objective in this study was to extend diaphragmatic pacing therapy to include paraplegic patients with high cervical spinal cord injuries between C3 and C5. INTRODUCTION: Diaphragmatic pacing has been used in patients experiencing ventilator-dependent respiratory failure due to spinal cord injury as a means to reduce or eliminate the need for mechanical ventilation. However, this technique relies on intact phrenic nerve function. Recently, phrenic nerve reconstruction with intercostal nerve grafting has expanded the indications for diaphragmatic pacing...
August 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28542087/validity-of-postmortem-glycated-hemoglobin-to-determine-status-of-diabetes-mellitus-in-corneal-donors
#6
Mark C Soper, Santica M Marcovina, Caroline K Hoover, Peter M Calhoun, Kristen E McCoy, Christopher G Stoeger, Gregory A Schmidt, Baha M Arafah, Marianne O Price, Loretta B Szczotka-Flynn, Jonathan H Lass
PURPOSE: To examine the stability of postmortem glycated hemoglobin (HbA1c) measurement and its relationship to premortem glycemia. METHODS: Postmortem blood samples were obtained from 32 donors (8 known diabetic) and shipped on ice to a central laboratory to examine the stability of HbA1c measurements during the first 9 postmortem days. Thirty-nine other suspected diabetic donors underwent comparison of premortem and postmortem HbA1c measurements. RESULTS: Postmortem HbA1c measurements remained stable after 9 postmortem days (all measurements within ±0...
May 23, 2017: Cornea
https://www.readbyqxmd.com/read/28457188/functional-tissue-engineering-a-prevascularized-cardiac-muscle-construct-for-validating-human-mesenchymal-stem-cells-engraftment-potential-in-vitro
#7
Mani T Valarmathi, John W Fuseler, Jay D Potts, Jeffrey M Davis, Robert L Price
The influence of somatic stem cells in the stimulation of mammalian cardiac muscle regeneration is still in its early stages, and so far, it has been difficult to determine the efficacy of the procedures that have been employed. The outstanding question remains whether stem cells derived from the bone marrow or some other location within or outside of the heart can populate a region of myocardial damage and transform into tissue-specific differentiated progenies, and also exhibit functional synchronization...
May 25, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28329352/costs-and-consequences-of-early-hospital-discharge-after-major-inpatient-surgery-in-older-adults
#8
Scott E Regenbogen, Anne H Cain-Nielsen, Edward C Norton, Lena M Chen, John D Birkmeyer, Jonathan S Skinner
Importance: As prospective payment transitions to bundled reimbursement, many US hospitals are implementing protocols to shorten hospitalization after major surgery. These efforts could have unintended consequences and increase overall surgical episode spending if they induce more frequent postdischarge care use or readmissions. Objective: To evaluate the association between early postoperative discharge practices and overall surgical episode spending and expenditures for postdischarge care use and readmissions...
May 17, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/28198539/cytomegalovirus-infection-alters-phenotypes-of-different-%C3%AE-%C3%AE-t-cell-subsets-in-renal-transplant-recipients-with-long-term-stable-graft-function
#9
Silvia Lee, Jacquita S Affandi, Ashley B Irish, Patricia Price
Cytomegalovirus (CMV) infection alters the phenotypic profiles of T-cells and NK cells in healthy and immunocompromised individuals. Here, we examined the effects of CMV infection on the phenotype and functions of γδ T-cell subsets in renal transplant recipients (RTR) stable several years after transplantation (n = 80) and healthy controls (n = 72). Differentiation status, function, and expression of HLA-DR, CD57, and LIR-1 on Vδ2(-) and Vδ2(+) γδ T-cells were examined in peripheral blood cells using flow cytometry...
August 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28157815/resistance-of-mandibular-polyurethane-replicas-to-fracture-after-removal-of-blocks-from-the-symphysis-and-ramus
#10
Mohanad Al-Sabbagh, Georgios Romanos, Scott R Price, David A Puleo, Fonda G Robinson, Mark V Thomas
BACKGROUND: When block grafts are harvested intraorally, the donor sites may act as stress concentrators and alter the structural integrity of the mandible. PURPOSE: The study aimed to compare displacement and load failure between intact polyurethane mandibular replicas and similar replicas from which blocks were taken at the symphysis or the ramus. It also aimed to identify trends of load failure. MATERIALS AND METHODS: Thirty-five mandibular replicas were tested to failure with an electromagnetic material testing unit...
June 2017: Implant Dentistry
https://www.readbyqxmd.com/read/28097811/fc-silent-anti-cd154-domain-antibody-effectively-prevents-nonhuman-primate-renal-allograft-rejection
#11
S C Kim, W Wakwe, L B Higginbotham, D V Mathews, C P Breeden, A C Stephenson, J Jenkins, E Strobert, K Price, L Price, R Kuhn, H Wang, A Yamniuk, S Suchard, A B Farris, T C Pearson, C P Larsen, M L Ford, A Suri, S Nadler, A B Adams
The advent of costimulation blockade provides the prospect for targeted therapy with improved graft survival in transplant patients. Perhaps the most effective costimulation blockade in experimental models is the use of reagents to block the CD40/CD154 pathway. Unfortunately, successful clinical translation of anti-CD154 therapy has not been achieved. In an attempt to develop an agent that is as effective as previous CD154 blocking antibodies but lacks the risk of thromboembolism, we evaluated the efficacy and safety of a novel anti-human CD154 domain antibody (dAb, BMS-986004)...
May 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/27993208/the-price-of-surgery-markup-of-operative-procedures-in-the-united-states
#12
COMPARATIVE STUDY
Faiz Gani, Martin A Makary, Timothy M Pawlik
BACKGROUND: Despite cost containment efforts, the price for surgery is not subject to any regulations. We sought to characterize and compare variability in pricing for commonly performed major surgical procedures across the United States. METHODS: Medicare claims corresponding to eight major surgical procedures (aortic aneurysm repair, aortic valvuloplasty, carotid endartectomy, coronary artery bypass grafting, esophagectomy, pancreatectomy, liver resection, and colectomy) were identified using the Medicare Provider Utilization and Payment Data Physician and Other Supplier Public Use File for 2013...
February 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/27955936/do-prices-reflect-the-costs-of-cardiac-surgery-in-the-elderly
#13
Pedro Coelho, Vanessa Rodrigues, Luís Miranda, José Fragata, Pedro Pita Barros
INTRODUCTION: Payment for cardiac surgery in Portugal is based on a contract agreement between hospitals and the health ministry. Our aim was to compare the prices paid according to this contract agreement with calculated costs in a population of patients aged ≥65 years undergoing cardiac surgery in one hospital department. METHODS: Data on 250 patients operated between September 2011 and September 2012 were prospectively collected. The procedures studied were coronary artery bypass graft surgery (CABG) (n=67), valve surgery (n=156) and combined CABG and valve surgery (n=27)...
January 2017: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
https://www.readbyqxmd.com/read/27862079/discarded-livers-find-a-new-life-engineered-liver-grafts-using-hepatocytes-recovered-from-marginal-livers
#14
Basak E Uygun, Maria-Louisa Izamis, Maria Jaramillo, Yibin Chen, Gavrielle Price, Sinan Ozer, Martin L Yarmush
Treatment for end-stage liver failure is restricted by the critical shortage of donor organs; about 4000 people die in the USA while waiting for a transplantable organ. This situation has been a major driving force behind the rise of tissue engineering to build artificial tissues/organs. Recent advancements in creating transplantable liver grafts using decellularized liver scaffolds bring the field closer to clinical translation. However, a source of readily available and highly functional adult hepatocytes in adequate numbers for regenerative liver therapies still remains unclear...
November 8, 2016: Artificial Organs
https://www.readbyqxmd.com/read/27787489/chimney-versus-fenestrated-endovascular-aortic-repair-for-juxta-renal-aneurysms
#15
Caroline Caradu, Xavier Berard, Gérard Sassoust, Dominique Midy, Eric Ducasse
BACKGROUND: Anatomical constrains, high price and manufacturing delay restrict fenestrated (F)-endovascular aortic repair (EVAR) to elective patients in specialized centers. Chimney graft (CG)-EVAR offers an alternative but uncertainties remain over target vessel's patency and type Ia endoleaks (ELs). METHODS: We reviewed the literature reporting F-EVAR and CG-EVAR for juxtarenal aneurysms between January 2005 and July 2016. RESULTS: Fifteen studies on F-EVAR, 8 on CG-EVAR and 5 on both techniques were included; 1748 F-EVAR patients (3993 target vessels) vs 757 (1158 target vessels, 13% symptomatic and 7% ruptured)...
October 27, 2016: Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/27771318/diagnosis-of-aortic-graft-infection-a-case-definition-by-the-management-of-aortic-graft-infection-collaboration-magic
#16
O T A Lyons, M Baguneid, T D Barwick, R E Bell, N Foster, S Homer-Vanniasinkam, S Hopkins, A Hussain, K Katsanos, B Modarai, J A T Sandoe, S Thomas, N M Price
OBJECTIVE/BACKGROUND: The management of aortic graft infection (AGI) is highly complex and in the absence of a universally accepted case definition and evidence-based guidelines, clinical approaches and outcomes vary widely. The objective was to define precise criteria for diagnosing AGI. METHODS: A process of expert review and consensus, involving formal collaboration between vascular surgeons, infection specialists, and radiologists from several English National Health Service hospital Trusts with large vascular services (Management of Aortic Graft Infection Collaboration [MAGIC]), produced the definition...
December 2016: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/27689202/gastrointestinal-side-effects-of-post-transplant-therapy
#17
REVIEW
Valerian Ciprian Lucan, Luisa Berardinelli
Modern immunosuppressive therapy has produced a real revolution in renal and organ transplantation but it comes with the price of multiple side effects. There are many gastrointestinal (GI) complications that are the consequence of transplant immunosuppressant medication. In fact, for any immunosuppressant therapy, certain standardized precepts and attitudes that aim to reduce the incidence and the impact of the medication side effects must be applied. Many patients undergo renal transplantation and the physicians have to be aware of the advantages and the risks associated...
September 2016: Journal of Gastrointestinal and Liver Diseases: JGLD
https://www.readbyqxmd.com/read/27628202/enhanced-therapeutic-efficacy-of-doxorubicin-for-breast-cancer-using-chitosan-oligosaccharide-modified-halloysite-nanotubes
#18
Jing Yang, Yanping Wu, Yan Shen, Changren Zhou, Yi-Fang Li, Rong-Rong He, Mingxian Liu
Halloysite nanotubes (HNTs) are natural aluminosilicates with unique hollow lumen structure, also having high specific area, good biocompatibility, nontoxicity, and low price. Here, we designed a chitosan oligosaccharide-grafted HNTs (HNTs-g-COS) as a doxorubicin (DOX) carrier for treating breast cancer both in vitro and in vivo. The structure of HNTs-g-COS was first characterized by various methods. HNTs-g-COS showed positively charged surface and improved hemocompatibility. DOX-loaded HNTs-g-COS (DOX@HNTs-g-COS) released in cell lysate in a controlled manner...
October 12, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27605410/dual-kidney-allocation-score-a-novel-algorithm-utilizing-expanded-donor-criteria-for-the-allocation-of-dual-kidneys-in-adults
#19
Adam P Johnson, Thea P Price, Benjamin Lieby, Cataldo Doria
BACKGROUND Dual kidney transplantation (DKT) of expanded-criteria donors is a cost-intensive procedure that aims to increase the pool of available deceased organ donors and has demonstrated equivalent outcomes to expanded-criteria single kidney transplantation (eSKT). The objective of this study was to develop an allocation score based on predicted graft survival from historical dual and single kidney donors. MATERIAL AND METHODS We analyzed United Network for Organ Sharing (UNOS) data for 1547 DKT and 26 381 eSKT performed between January 1994 and September 2013...
September 8, 2016: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/27343909/bilateral-internal-thoracic-artery-grafting-does-graft-configuration-affect-outcome
#20
J Trent Magruder, Allen Young, Joshua C Grimm, John V Conte, Ashish S Shah, Kaushik Mandal, Christopher M Sciortino, Kenton J Zehr, Duke E Cameron, Joel Price
BACKGROUND: Despite evidence that bilateral internal thoracic arteries (ITAs) improve long-term survival after coronary artery bypass grafting (CABG), uptake of this technique remains low. We directly compared bilateral ITA graft configurations and examined long-term outcomes. METHODS: We reviewed 762 patients who underwent CABG using bilateral ITA grafts at our institution between 1997 and 2014. The outcomes were mortality and a composite revascularization end point defined as need for percutaneous coronary intervention or repeat CABG...
July 2016: Journal of Thoracic and Cardiovascular Surgery
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