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https://www.readbyqxmd.com/read/28198539/cytomegalovirus-infection-alters-phenotypes-of-different-%C3%AE-%C3%AE-t-cell-subsets-in-renal-transplant-recipients-with-long-term-stable-graft-function
#1
Silvia Lee, Jacquita S Affandi, Ashley B Irish, Patricia Price
Cytomegalovirus (CMV) infection alters the phenotypic profiles of T-cells and NK cells in healthy and immunocompromised individuals. Here, we examined the effects of CMV infection on the phenotype and functions of γδ T-cell subsets in renal transplant recipients (RTR) stable several years after transplantation (n = 80) and healthy controls (n = 72). Differentiation status, function, and expression of HLA-DR, CD57 and LIR-1 on Vδ2- and Vδ2+ γδ T-cells were examined in peripheral blood cells using flow cytometry...
February 15, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28157815/resistance-of-mandibular-polyurethane-replicas-to-fracture-after-removal-of-blocks-from-the-symphysis-and-ramus
#2
Mohanad Al-Sabbagh, Georgios Romanos, Scott R Price, David A Puleo, Fonda G Robinson, Mark V Thomas
BACKGROUND: When block grafts are harvested intraorally, the donor sites may act as stress concentrators and alter the structural integrity of the mandible. PURPOSE: The study aimed to compare displacement and load failure between intact polyurethane mandibular replicas and similar replicas from which blocks were taken at the symphysis or the ramus. It also aimed to identify trends of load failure. MATERIALS AND METHODS: Thirty-five mandibular replicas were tested to failure with an electromagnetic material testing unit...
February 2, 2017: Implant Dentistry
https://www.readbyqxmd.com/read/28097811/fc-silent-anti-cd154-domain-antibody-effectively-prevents-non-human-primate-renal-allograft-rejection
#3
Steven C Kim, Walter Wakwe, Laura B Higginbotham, David V Mathews, Cynthia P Breeden, Allison C Stephenson, Joe Jenkins, Elizabeth Strobert, Karen Price, Laura Price, Robert Kuhn, Haiqing Wang, Aaron Yamniuk, Suzanne Suchard, Alton B Farris, Thomas C Pearson, Christian P Larsen, Mandy L Ford, Anish Suri, Steven Nadler, Andrew B Adams
The advent of costimulation blockade provides the prospect for targeted therapy with improved graft survival in transplant patients. Perhaps the most effective costimulation blockade in experimental models is the use of reagents to block the CD40/CD154 pathway. Unfortunately, successful clinical translation of anti-CD154 therapy has not been achieved. In an attempt to develop an agent that is as effective as previous CD154 blocking antibodies but lacks the risk of thromboembolism, we evaluated the efficacy and safety of a novel anti-human CD154 domain antibody (dAb, BMS-986004)...
January 17, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/27993208/the-price-of-surgery-markup-of-operative-procedures-in-the-united-states
#4
Faiz Gani, Martin A Makary, Timothy M Pawlik
BACKGROUND: Despite cost containment efforts, the price for surgery is not subject to any regulations. We sought to characterize and compare variability in pricing for commonly performed major surgical procedures across the United States. METHODS: Medicare claims corresponding to eight major surgical procedures (aortic aneurysm repair, aortic valvuloplasty, carotid endartectomy, coronary artery bypass grafting, esophagectomy, pancreatectomy, liver resection, and colectomy) were identified using the Medicare Provider Utilization and Payment Data Physician and Other Supplier Public Use File for 2013...
February 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/27955936/do-prices-reflect-the-costs-of-cardiac-surgery-in-the-elderly
#5
Pedro Coelho, Vanessa Rodrigues, Luís Miranda, José Fragata, Pedro Pita Barros
INTRODUCTION: Payment for cardiac surgery in Portugal is based on a contract agreement between hospitals and the health ministry. Our aim was to compare the prices paid according to this contract agreement with calculated costs in a population of patients aged ≥65 years undergoing cardiac surgery in one hospital department. METHODS: Data on 250 patients operated between September 2011 and September 2012 were prospectively collected. The procedures studied were coronary artery bypass graft surgery (CABG) (n=67), valve surgery (n=156) and combined CABG and valve surgery (n=27)...
January 2017: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
https://www.readbyqxmd.com/read/27862079/discarded-livers-find-a-new-life-engineered-liver-grafts-using-hepatocytes-recovered-from-marginal-livers
#6
Basak E Uygun, Maria-Louisa Izamis, Maria Jaramillo, Yibin Chen, Gavrielle Price, Sinan Ozer, Martin L Yarmush
Treatment for end-stage liver failure is restricted by the critical shortage of donor organs; about 4000 people die in the USA while waiting for a transplantable organ. This situation has been a major driving force behind the rise of tissue engineering to build artificial tissues/organs. Recent advancements in creating transplantable liver grafts using decellularized liver scaffolds bring the field closer to clinical translation. However, a source of readily available and highly functional adult hepatocytes in adequate numbers for regenerative liver therapies still remains unclear...
November 8, 2016: Artificial Organs
https://www.readbyqxmd.com/read/27787489/chimney-versus-fenestrated-endovascular-aortic-repair-for-juxta-renal-aneurysms
#7
Caroline Caradu, Xavier Berard, Gérard Sassoust, Dominique Midy, Eric Ducasse
BACKGROUND: Anatomical constrains, high price and manufacturing delay restrict fenestrated (F)-endovascular aortic repair (EVAR) to elective patients in specialized centers. Chimney graft (CG)-EVAR offers an alternative but uncertainties remain over target vessel's patency and type Ia endoleaks (ELs). METHODS: We reviewed the literature reporting F-EVAR and CG-EVAR for juxtarenal aneurysms between January 2005 and July 2016. RESULTS: Fifteen studies on F-EVAR, 8 on CG-EVAR and 5 on both techniques were included; 1748 F-EVAR patients (3993 target vessels) vs 757 (1158 target vessels, 13% symptomatic and 7% ruptured)...
October 27, 2016: Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/27771318/diagnosis-of-aortic-graft-infection-a-case-definition-by-the-management-of-aortic-graft-infection-collaboration-magic
#8
O T A Lyons, M Baguneid, T D Barwick, R E Bell, N Foster, S Homer-Vanniasinkam, S Hopkins, A Hussain, K Katsanos, B Modarai, J A T Sandoe, S Thomas, N M Price
OBJECTIVE/BACKGROUND: The management of aortic graft infection (AGI) is highly complex and in the absence of a universally accepted case definition and evidence-based guidelines, clinical approaches and outcomes vary widely. The objective was to define precise criteria for diagnosing AGI. METHODS: A process of expert review and consensus, involving formal collaboration between vascular surgeons, infection specialists, and radiologists from several English National Health Service hospital Trusts with large vascular services (Management of Aortic Graft Infection Collaboration [MAGIC]), produced the definition...
December 2016: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/27689202/gastrointestinal-side-effects-of-post-transplant-therapy
#9
REVIEW
Valerian Ciprian Lucan, Luisa Berardinelli
Modern immunosuppressive therapy has produced a real revolution in renal and organ transplantation but it comes with the price of multiple side effects. There are many gastrointestinal (GI) complications that are the consequence of transplant immunosuppressant medication. In fact, for any immunosuppressant therapy, certain standardized precepts and attitudes that aim to reduce the incidence and the impact of the medication side effects must be applied. Many patients undergo renal transplantation and the physicians have to be aware of the advantages and the risks associated...
September 2016: Journal of Gastrointestinal and Liver Diseases: JGLD
https://www.readbyqxmd.com/read/27628202/enhanced-therapeutic-efficacy-of-doxorubicin-for-breast-cancer-using-chitosan-oligosaccharide-modified-halloysite-nanotubes
#10
Jing Yang, Yanping Wu, Yan Shen, Changren Zhou, Yi-Fang Li, Rong-Rong He, Mingxian Liu
Halloysite nanotubes (HNTs) are natural aluminosilicates with unique hollow lumen structure, also having high specific area, good biocompatibility, nontoxicity, and low price. Here, we designed a chitosan oligosaccharide-grafted HNTs (HNTs-g-COS) as a doxorubicin (DOX) carrier for treating breast cancer both in vitro and in vivo. The structure of HNTs-g-COS was first characterized by various methods. HNTs-g-COS showed positively charged surface and improved hemocompatibility. DOX-loaded HNTs-g-COS (DOX@HNTs-g-COS) released in cell lysate in a controlled manner...
October 12, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27605410/dual-kidney-allocation-score-a-novel-algorithm-utilizing-expanded-donor-criteria-for-the-allocation-of-dual-kidneys-in-adults
#11
Adam P Johnson, Thea P Price, Benjamin Lieby, Cataldo Doria
BACKGROUND Dual kidney transplantation (DKT) of expanded-criteria donors is a cost-intensive procedure that aims to increase the pool of available deceased organ donors and has demonstrated equivalent outcomes to expanded-criteria single kidney transplantation (eSKT). The objective of this study was to develop an allocation score based on predicted graft survival from historical dual and single kidney donors. MATERIAL AND METHODS We analyzed United Network for Organ Sharing (UNOS) data for 1547 DKT and 26 381 eSKT performed between January 1994 and September 2013...
September 8, 2016: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/27343909/bilateral-internal-thoracic-artery-grafting-does-graft-configuration-affect-outcome
#12
J Trent Magruder, Allen Young, Joshua C Grimm, John V Conte, Ashish S Shah, Kaushik Mandal, Christopher M Sciortino, Kenton J Zehr, Duke E Cameron, Joel Price
BACKGROUND: Despite evidence that bilateral internal thoracic arteries (ITAs) improve long-term survival after coronary artery bypass grafting (CABG), uptake of this technique remains low. We directly compared bilateral ITA graft configurations and examined long-term outcomes. METHODS: We reviewed 762 patients who underwent CABG using bilateral ITA grafts at our institution between 1997 and 2014. The outcomes were mortality and a composite revascularization end point defined as need for percutaneous coronary intervention or repeat CABG...
July 2016: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/27190198/moderate-hypothermia-%C3%A2-24-and-%C3%A2-28%C3%A2-c-with-hypothermic-circulatory-arrest-for-proximal-aortic-operations-in-patients-with-previous-cardiac-surgery
#13
Ourania Preventza, Andrea Garcia, Sarang A Kashyap, Shahab Akvan, Denton A Cooley, Kiki Simpson, Athina Rammou, Matt D Price, Shuab Omer, Faisal G Bakaeen, Lorraine D Cornwell, Joseph S Coselli
OBJECTIVES: To determine whether, in patients with previous cardiac operations, moderate hypothermia (between 24 and 28°C) for hypothermic circulatory arrest (HCA) during antegrade cerebral perfusion (ACP) is safe for use during surgery on the proximal aorta and transverse aortic arch. METHODS: Over a 7-year period, 118 patients underwent ascending aortic and hemiarch repair (n = 70; 59.3%), total arch replacement (n = 47; 39.8%) or ascending aortic replacement to treat porcelain aorta (n = 1; 0...
November 2016: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/27183386/a-hotspot-for-autoimmune-t-cells-in-type-1-diabetes
#14
Brian D Stadinski, Reinhard Obst, Eric S Huseby
The ability of a single T cell antigen receptor (TCR) to cross-react with multiple antigens allows the finite number of T cells within an organism to respond to the compendium of pathogen challenges faced during a lifetime. Effective immune surveillance, however, comes at a price. TCR cross-reactivity can allow molecular mimics to spuriously activate autoimmune T cells; it also underlies T cell rejection of organ transplants and drives graft-versus-host disease. In this issue of the JCI, Cole and colleagues provide insight into how an insulin-reactive T cell cross-reacts with pathogen-derived antigens by focusing on a limited portion of the peptides to provide a hotspot for binding...
June 1, 2016: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/27108095/descemet-stripping-endothelial-keratoplasty-ten-year-endothelial-cell-loss-compared-with-penetrating-keratoplasty
#15
Marianne O Price, Peter Calhoun, Craig Kollman, Francis W Price, Jonathan H Lass
PURPOSE: To assess endothelial cell density (ECD) and model 10-year cell loss after Descemet stripping endothelial keratoplasty (DSEK), and to compare with results after penetrating keratoplasty (PK) performed for the same indications in the Cornea Donor Study (CDS). DESIGN: Retrospective, longitudinal study. PARTICIPANTS: Five hundred ninety DSEK recipients, 21 to 96 years of age, treated for Fuchs' dystrophy (n = 498; 84%), pseudophakic or aphakic corneal edema (n = 89; 15%), or other endothelial dysfunction (n = 3; <1%)...
July 2016: Ophthalmology
https://www.readbyqxmd.com/read/27039329/surgical-versus-conservative-interventions-for-treating-anterior-cruciate-ligament-injuries
#16
REVIEW
A Paul Monk, Loretta J Davies, Sally Hopewell, Kristina Harris, David J Beard, Andrew J Price
BACKGROUND: Rupture of the anterior cruciate ligament (ACL) is a common injury, mainly affecting young, physically active individuals. The injury is characterised by joint instability, leading to decreased activity, which can lead to poor knee-related quality of life. It is also associated with increased risk of secondary osteoarthritis of the knee. It is unclear whether stabilising the knee surgically via ACL reconstruction produces a better overall outcome than non-surgical (conservative) treatment...
April 3, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27009788/net-immobilization-of-%C3%AE-glucosidase-on-nonwoven-fabrics-to-lower-the-cost-of-cellulosic-ethanol-and-increase-cellulose-conversions
#17
Xing Zhu, Bin He, Changwen Zhao, Rong Fan, Lihua Zhang, Guan Wang, Yuhong Ma, Wantai Yang
The main limitation preventing the use of enzymatic cellulosic ethanol in industrial production is its higher cost which is mainly due to the elevated price of β-glucosidase (BG). Herein, we report on a simple strategy for the in-situ encapsulation of BG for repeated cellulosic ethanol production. In this strategy, BG was net-immobilized into a poly(ethylene glycol) (PEG) net-cloth layer on a PP nonwoven fabric by way of the visible light-induced surface controlled/living graft cross-linking polymerization...
March 24, 2016: Scientific Reports
https://www.readbyqxmd.com/read/26993975/association-of-hospital-prices-for-coronary-artery-bypass-grafting-with-hospital-quality-and-reimbursement
#18
Bria D Giacomino, Peter Cram, Mary Vaughan-Sarrazin, Yunshu Zhou, Saket Girotra
Although prices for medical services are known to vary markedly between hospitals, it remains unknown whether variation in hospital prices is explained by differences in hospital quality or reimbursement from major insurers. We obtained "out-of-pocket" price estimates for coronary artery bypass grafting (CABG) from a random sample of US hospitals for a hypothetical patient without medical insurance. We compared hospital CABG price to (1) "fair price" estimate from Healthcare Bluebook data using each hospital's zip code and (2) Society of Thoracic Surgeons composite CABG quality score and risk-adjusted mortality rate...
April 1, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/26983976/descemet-s-membrane-endothelial-keratoplasty-risk-of-immunologic-rejection-episodes-after-discontinuing-topical-corticosteroids
#19
Marianne O Price, Amanda Scanameo, Matthew T Feng, Francis W Price
PURPOSE: To assess the risk of immunologic rejection episodes if topical corticosteroids are discontinued 1 year after Descemet's membrane endothelial keratoplasty (DMEK) compared with continued once-per-day use. DESIGN: Prospective, longitudinal, parallel-group study. PARTICIPANTS: A total of 400 eyes of 259 DMEK recipients, aged 23 to 90 years. METHODS: Patients were enrolled 1 year after DMEK and allowed to choose whether to stop or continue once-daily topical corticosteroids to maximize compliance...
June 2016: Ophthalmology
https://www.readbyqxmd.com/read/26962702/immunization-practices-in-acute-lymphocytic-leukemia-and-post-hematopoietic-stem-cell-transplant-in-canadian-pediatric-hematology-oncology-centers
#20
Karina A Top, Anne Pham-Huy, Victoria Price, Lillian Sung, Dat Tran, Wendy Vaudry, Scott A Halperin, Gaston De Serres
There are no Canadian immunization guidelines for children treated for malignancy. Guidelines do exist for patients who underwent hematopoietic stem cell transplant (HSCT), but they provide broad timeframes for initiating vaccination; there is no standard schedule. The optimal approach to immunization in these populations is unclear. We sought to describe immunization practices at Canadian Pediatric Hematology/Oncology centers. A 43-item online questionnaire was distributed to the 16 programs in the C(17) research network of pediatric hematology/oncology centers to capture information on timing and criteria for immunization of patients with acute lymphocytic leukemia (ALL) and those who have undergone HSCT...
April 2, 2016: Human Vaccines & Immunotherapeutics
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