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JOURNAL ARTICLE
Lars-Olof Hattenbach, Peter Heinz, Nicolas Feltgen, Hans Hoerauf, Thomas Kohnen, Siegfried Priglinger, Werner Bachmann, Johannes Rieks, Nicole Eter, Thomas Reinhard
BACKGROUND: Survey by the commission for cross-sectoral ophthalmology, as a joint commission of the German Ophthalmological Society (DOG) and the Professional Association of German Ophthalmologists (BVA) on the effects of the SARS-CoV‑2 pandemic on ophthalmological patient care in Germany. METHODS: Online-based survey. RESULTS: A total of 1190 questionnaires were (partly) answered. With respect to outpatient care and consultations from 15 March to 15 April 2020, a total of 69 (5...
July 2021: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
#22
JOURNAL ARTICLE
Linda Oesterle, Reinhard Rüesch, Margarita G Todorova
No abstract text is available yet for this article.
April 2021: Klinische Monatsblätter Für Augenheilkunde
#23
JOURNAL ARTICLE
Sonja Heinzelmann, Daniel Böhringer, Philip Christian Maier, Berthold Seitz, Claus Cursiefen, Anna-Karina B Maier, Tina Dietrich-Ntoukas, Gerd Geerling, Arne Viestenz, Norbert Pfeiffer, Thomas Reinhard
BACKGROUND: Penetrating keratoplasty (PK) gets more and more reserved to cases of increasing complexity. In such cases, ocular comorbidities may limit graft survival following PK. A major cause for graft failure is endothelial graft rejection. Suture removal is a known risk factor for graft rejection. Nevertheless, there is no evidence-based regimen for rejection prophylaxis following suture removal. Therefore, a survey of rejection prophylaxis was conducted at 7 German keratoplasty centres...
February 25, 2021: Klinische Monatsblätter Für Augenheilkunde
#24
JOURNAL ARTICLE
Mukaddes Gürler, Walter Martz, Burak Taştekin, Tahmina Najafova, Reinhard B Dettmeyer
Food-derived alcohol is almost not in question due to its low concentration. Nevertheless, could it pose a problem for some risk groups and forensic cases? To answer this, we aimed to simultaneously evaluate ethanol and methanol ingredients of a variety of non-alcoholic foods in two different countries and estimate their possible health and forensic consequences. Alcohols in foods were analysed by headspace gas chromatography (HS-GC). Human average acute daily food consumptions and food-derived blood alcohol concentrations (BAC) were determined by using the data of the EFSA Nutrition Survey...
December 31, 2020: Journal of Analytical Toxicology
#25
JOURNAL ARTICLE
Florentia Dimitriou, Ursula Urner-Bloch, Corinne Eggenschwiler, Nicholas Mitsakakis, Joanna Mangana, Reinhard Dummer, Martin Urner
BACKGROUND: Treatment with immune checkpoint and BRAF/MEK inhibitors has significantly improved the survival of patients with advanced cutaneous melanoma and other metastatic malignancies. Therapy-related uveitis is a rare ocular adverse event, which may potentially lead to legal blindness. The epidemiology of treatment-related uveitis is currently insufficiently known. PATIENTS AND METHODS: In this cohort study, we asked whether exposure to either immune checkpoint or BRAF/MEK inhibitors was associated with a higher risk of developing uveitis compared with the general population...
December 26, 2020: European Journal of Cancer
#26
JOURNAL ARTICLE
C Deubel, D Böhringer, A Anton, T Reinhard, J Lübke
BACKGROUND: Excimer laser trabeculotomy (ELT) is a minimally invasive procedure to lower the intraocular pressure (IOP) via a photo-ablative laser that is applied to the trabecular meshwork. With this procedure, it is possible to improve the outflow of the aqueous humor. Until now, a limited number of studies examining mostly relatively small sample sizes with midterm follow-up exist. We therefore present the analysis of a large ELT cohort in a long-term follow-up. METHODS: We recorded data from 580 patients who underwent ELT or combined ELT with cataract surgery at our institution from November 2000 until March 2011...
December 8, 2020: Graefe's Archive for Clinical and Experimental Ophthalmology
#27
JOURNAL ARTICLE
Theresa Steeb, Anja Wessely, Mareike Alter, Christiane Bayerl, Armin Bender, Guido Bruning, Evelyn Dabrowski, Dirk Debus, Nina Devereux, Edgar Dippel, Konstantin Drexler, Pia Dücker, Reinhard Dummer, Steffen Emmert, Peter Elsner, Alexander Enk, Christoffer Gebhardt, Anja Gesierich, Matthias Goebeler, Sergij Goerdt, Steven Goetze, Ralf Gutzmer, Sebastian Haferkamp, Gesina Hansel, Jessica C Hassel, Lucie Heinzerling, Katharina C Kähler, Kjell M Kaume, Wolfgang Krapf, Nicole Kreuzberg, Percy Lehmann, Elisabeth Livingstone, Harald Löffler, Carmen Loquai, Cornelia Mauch, Johanna Mangana, Friedegund Meier, Markus Meissner, Rose K C Moritz, Lara Valeska Maul, Verena Müller, Peter Mohr, Alexander Navarini, Ahn Van Nguyen, Christiane Pfeiffer, Claudia Pföhler, Christian Posch, Erika Richtig, Rainer Rompel, Michael M Sachse, Stefanie Sauder, Dirk Schadendorf, Kerstin Schatton, Hans-Joachim Schulze, Erwin Schultz, Bastian Schilling, Matthias Schmuth, Jan C Simon, Markus Streit, Patrick Terheyden, Alexander Thiem, Thomas Tüting, Julia Welzel, Gerhard Weyandt, Ulrich Wesselmann, Uwe Wollina, Mirjana Ziemer, Lisa Zimmer, Markus Zutt, Carola Berking, Max Schlaak, Markus V Heppt
PURPOSE: Uveal melanoma (UM) is an orphan cancer of high unmet medical need. Current patterns of care and surveillance remain unclear as they are situated in an interdisciplinary setting. METHODS: A questionnaire addressing the patterns of care and surveillance in the management of patients with uveal melanoma was distributed to 70 skin cancer centers in Austria, Germany and Switzerland. Frequency distributions of responses for each item of the questionnaire were calculated...
November 21, 2020: Journal of Cancer Research and Clinical Oncology
#28
JOURNAL ARTICLE
Dorottya Hajdu, Reinhard Told, Orsolya Angeli, Guenther Weigert, Andreas Pollreisz, Ursula Schmidt-Erfurth, Stefan Sacu
PURPOSE: To evaluate the characteristics and morphological alterations in central retinal ischemia caused by diabetic retinopathy (DR) or retinal vein occlusion (RVO) as seen in optical coherence tomography angiography (OCTA) and their relationship to visual acuity. METHODS: Swept-source optical coherence tomography (SSOCT) and OCTA (Topcon, Triton) data of patients with central involving retinal ischemia were analyzed in this cross-sectional study. The following parameters were evaluated: vessel parameters, foveal avascular zone (FAZ), intraretinal cysts (IRC), microaneurysms (MA), vascular collaterals in the superficial (SCP) and deep plexuses (DCP), hyperreflective foci (HRF), epiretinal membrane (ERM), external limiting membrane (ELM) and ellipsoid zone (EZ) disruption, as well as the disorganization of retinal inner layers (DRIL)...
2020: PloS One
#29
JOURNAL ARTICLE
Lars-Olof Hattenbach, Peter Heinz, Nicolas Feltgen, Hans Hoerauf, Thomas Kohnen, Siegfried Priglinger, Werner Bachmann, Johannes Rieks, Nicole Eter, Thomas Reinhard
BACKGROUND: Survey by the commission for cross-sectoral ophthalmology, as a joint commission of the German Ophthalmological Society (DOG) and the Professional Association of German Ophthalmologists (BVA) on the effects of the SARS-CoV‑2 pandemic on ophthalmological patient care in Germany. METHODS: Online-based survey. RESULTS: A total of 1190 questionnaires were (partly) answered. With respect to outpatient care and consultations from 15 March to 15 April 2020, a total of 69 (5...
August 26, 2020: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
#30
JOURNAL ARTICLE
Vasileios Bampidis, Giovanna Azimonti, Maria de Lourdes Bastos, Henrik Christensen, Birgit Dusemund, Maryline Kouba, Mojca Kos Durjava, Marta López-Alonso, Secundino López Puente, Francesca Marcon, Baltasar Mayo, Alena Pechová, Mariana Petkova, Fernando Ramos, Yolanda Sanz, Roberto Edoardo Villa, Ruud Woutersen, Georges Bories, Paul Brantom, Derek Renshaw, Josef Rudolf Schlatter, Reinhard Ackerl, Orsolya Holczknecht, Hans Steinkellner, Maria Vittoria Vettori, Jürgen Gropp
Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety and efficacy of astaxanthin-dimethyldisuccinate (ATX-DMDS) for salmonids, crustaceans and other fish. The applicant has provided evidence that ATX-DMDS currently on the market complies with the conditions of authorisation for salmon and trout. ATX and ATX-DMDS are safe for salmonids, crustaceans and fish up to 100 mg ATX/kg complete diet, corresponding to 138 mg ATX-DMDS/kg...
December 2019: EFSA journal
#31
JOURNAL ARTICLE
Masanari Takamiya, Johannes Stegmaier, Andrei Yu Kobitski, Benjamin Schott, Benjamin D Weger, Dimitra Margariti, Angel R Cereceda Delgado, Victor Gourain, Tim Scherr, Lixin Yang, Sebastian Sorge, Jens C Otte, Volker Hartmann, Jos van Wezel, Rainer Stotzka, Thomas Reinhard, Günther Schlunck, Thomas Dickmeis, Sepand Rastegar, Ralf Mikut, Gerd Ulrich Nienhaus, Uwe Strähle
Cranial neural crest (NC) contributes to the developing vertebrate eye. By multidimensional, quantitative imaging, we traced the origin of the ocular NC cells to two distinct NC populations that differ in the maintenance of sox10 expression, Wnt signalling, origin, route, mode and destination of migration. The first NC population migrates to the proximal and the second NC cell group populates the distal (anterior) part of the eye. By analysing zebrafish pax6a/b compound mutants presenting anterior segment dysgenesis, we demonstrate that Pax6a/b guide the two NC populations to distinct proximodistal locations...
June 17, 2020: PLoS Genetics
#32
JOURNAL ARTICLE
Gottfried Martin, Jan Lübke, Suzanna Schefold, Jens F Jordan, Günther Schlunck, Thomas Reinhard, Thananthorn Kanokwijitsilp, Oswald Prucker, Jürgen Rühe, Alexandra Anton
The authors describe a process that may eventually reduce the risk of scar formation after glaucoma surgery. For this, a thin hydrogel coating is photochemically generated and linked to the sclera surface at the surgical site. This coating is generated from a photoreactive prepolymer containing anthraquinone groups, which is administered as a thin pad to the sclera surface. Short UV irradiation leads to a reaction of the photogroups with neighboring chains via C-H insertion crosslinking, thus transforming the precursor polymer into a hydrogel...
January 1, 2020: Macromolecular Rapid Communications
#33
JOURNAL ARTICLE
Paul Nathan, Paolo A Ascierto, John Haanen, Enrique Espinosa, Lev Demidov, Claus Garbe, Michele Guida, Paul Lorigan, Vanna Chiarion-Sileni, Helen Gogas, Michele Maio, Maria Teresa Fierro, Christoph Hoeller, Patrick Terheyden, Ralf Gutzmer, Tormod K Guren, Dimitrios Bafaloukos, Piotr Rutkowski, Ruth Plummer, Ashita Waterston, Martin Kaatz, Mario Mandala, Ivan Marquez-Rodas, Eva Muñoz-Couselo, Reinhard Dummer, Elena Grigoryeva, Tina C Young, Dirk Schadendorf
BACKGROUND: Nivolumab has been widely studied in non-acral cutaneous melanoma; however, limited data are available in other melanoma subtypes. We report outcomes by melanoma subtype in patients who received nivolumab after progression on prior ipilimumab. PATIENTS AND METHODS: CheckMate 172 was a phase II, single-arm, open-label, multicentre study that evaluated nivolumab in patients with advanced melanoma who progressed on or after ipilimumab. Patients received 3 mg/kg of nivolumab, every 2 weeks for up to 2 years...
August 21, 2019: European Journal of Cancer
#34
JOURNAL ARTICLE
Jan Luebke, L Bryniok, M Neuburger, J F Jordan, D Boehringer, T Reinhard, T Wecker, A Anton
PURPOSE: Intraocular pressure (IOP) measurement can be performed with different methods. Newer methods have to be compared to the standard method, the Goldmann applanation tonometry (GAT). We herein compare two air-puff tonometers, the non-contact tonometer (Tomey NCT) and the Corvis ST (CST) with GAT in eyes with a broad spectrum of IOP. METHODS: Two hundred and forty-nine eyes of 249 patients (with diagnosis of either glaucoma or ocular hypertension) were included in this monocenter prospective cohort study...
April 9, 2019: International Ophthalmology
#35
JOURNAL ARTICLE
Reinhard Angermann, Martin Stattin, Claus Zehetner
PURPOSE: To describe the challenging diagnosis of ocular nocardiosis in a patient with anaplastic astrocytoma Methods: A 56-year-old patient with recurrent cerebral anaplastic astrocytoma and a history of surgical resection, who underwent radiotherapy and chemotherapy, presented with a unilateral white subretinal mass at the posterior pole of his left eye. Vitrectomy and fine-needle biopsy of the vitreous as well as the subretinal mass were performed. RESULTS: Magnetic resonance imaging verified progression of the lesion's size at follow-up...
August 10, 2018: Ocular Immunology and Inflammation
#36
JOURNAL ARTICLE
Clemens Alexander Klaus Lange, Patrick Lehnert, Stefaniya Konstantinova Boneva, Peipei Zhang, Franziska Ludwig, Martin Boeker, Klaus Hoffmeier, Ralf Horres, Günther Schlunck, Thomas Reinhard, Daniel Böhringer, Claudia Auw-Haedrich
PURPOSE: To investigate the expression profile of the hypoxia-inducible transcription factor-1α (HIF-1α) and its downstream targets in malignancies of the ocular adnexa and to determine its relevance as a prognostic factor for clinical outcome. METHODS: We included 49 subjects with malignant tumours (25 squamous cell carcinomas (SCC), 15 non-Hodgkin lymphomas, 9 melanomas) and 30 patients with benign tumours of the ocular adnexa (13 papillomas, 7 reactive lymphoid hyperplasias (RLHs) and 10 nevi) as controls...
November 2018: Eye
#37
REVIEW
Thabo Lapp, Philip Maier, Daniel Böhringer, Thomas Reinhard
The surgical technique of limbokeratoplasty (limbo-KP) was initially established for the treatment of severe limbal deficiencies. Besides improving visual acuity, surgery is aimed at ensuring complete, long-lasting epithelialization of the ocular surface. Due to the extension of the indication spectrum, limbo-KPs are also used in various forms of epithelial/stromal corneal dystrophies such as lattice and granular (transforming growth factor beta-induced [TGFBI] gene mutation associated) dystrophies. The objective of limbo-KP is to ensure prolonged clear graft survival without a recurrence of the dystrophy as otherwise observed after conventional keratoplasty...
June 2018: Klinische Monatsblätter Für Augenheilkunde
#38
JOURNAL ARTICLE
Jessica G Rushton, Reinhard Ertl, Dieter Klein, Alexander Tichy, Barbara Nell
OBJECTIVES: Feline diffuse iris melanoma (FDIM) is the most common malignant primary intraocular tumour in cats, with reported metastases rates between 19% and 63%. Currently, the only available diagnostic tool for a tentative diagnosis is histopathological examination of the enucleated eye. Therefore, the veterinary ophthalmologist is often faced with the dilemma of whether to enucleate an oftentimes visual eye or to continue monitoring, with the risk of metastases developing. In the past, cell-free DNA (cfDNA) gained more attention in human medicine, especially in the field of oncology...
February 2019: Journal of Feline Medicine and Surgery
#39
JOURNAL ARTICLE
Anselm Jünemann, Bettina Hohberger, Jürgen Rech, Ahmed Sheriff, Qin Fu, Ursula Schlötzer-Schrehardt, Reinhard Edmund Voll, Sabine Bartel, Hubert Kalbacher, Johan Hoebeke, Robert Rejdak, Folkert Horn, Gerd Wallukat, Rudolf Kunze, Martin Herrmann
Glaucoma is a frequent ocular disease that may lead to blindness. Primary open-angle glaucoma (POAG) and ocular hypertension (OHT) are common diseases with increased intraocular pressure (IOP), which are mainly responsible for these disorders. Their pathogenesis is widely unknown. We screened the sera of patients with POAG and OHT for the prevalence of autoantibodies (AAb) against G protein-coupled receptors (GPCRs) in comparison to controls. Employing frequency modulation of spontaneously contracting neonatal rat cardiomyocytes in vitro , agonistic GPCR AAb were to be detected in roughly 75% of the patients with POAG and OHT, however, not in controls...
2018: Frontiers in Immunology
#40
JOURNAL ARTICLE
Melanie Lohrberg, Reinhard Pabst, Jörg Wilting
BACKGROUND: The lymphatic vascular pattern in the head of mice has rarely been studied, due to problems of sectioning and immunostaining of complex bony structures. Therefore, the association of head lymphoid tissues with the lymphatics has remained unknown although the mouse is the most often used species in immunology. RESULTS: Here, we studied the association of nasal and nasolacrimal duct lymphatics with lymphoid aggregates in 14-day-old and 2-month-old mice...
January 25, 2018: BMC Immunology
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