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https://www.readbyqxmd.com/read/29649838/-limbokeratoplasty-to-treat-lattice-and-granular-corneal-dystrophies
#1
Thabo Lapp, Philip Maier, Daniel Böhringer, Thomas Reinhard
The surgical technique of limbokeratoplasty (limbo-KP) was initially established for the treatment of severe limbal deficiencies. Besides improving visual acuity, surgery is aimed at ensuring complete, long-lasting epithelialization of the ocular surface. Due to the extension of the indication spectrum, limbo-KPs are also used in various forms of epithelial/stromal corneal dystrophies such as lattice and granular (transforming growth factor beta-induced [TGFBI] gene mutation associated) dystrophies. The objective of limbo-KP is to ensure prolonged clear graft survival without a recurrence of the dystrophy as otherwise observed after conventional keratoplasty...
April 12, 2018: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/29529957/circulating-cell-free-dna-does-not-harbour-a-diagnostic-benefit-in-cats-with-feline-diffuse-iris-melanomas
#2
Jessica G Rushton, Reinhard Ertl, Dieter Klein, Alexander Tichy, Barbara Nell
Objectives Feline diffuse iris melanoma (FDIM) is the most common malignant primary intraocular tumour in cats, with reported metastases rates between 19% and 63%. Currently, the only available diagnostic tool for a tentative diagnosis is histopathological examination of the enucleated eye. Therefore, the veterinary ophthalmologist is often faced with the dilemma of whether to enucleate an oftentimes visual eye or to continue monitoring, with the risk of metastases developing. In the past, cell-free DNA (cfDNA) gained more attention in human medicine, especially in the field of oncology...
March 1, 2018: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/29483909/agonistic-autoantibodies-to-the-%C3%AE-2-adrenergic-receptor-involved-in-the-pathogenesis-of-open-angle-glaucoma
#3
Anselm Jünemann, Bettina Hohberger, Jürgen Rech, Ahmed Sheriff, Qin Fu, Ursula Schlötzer-Schrehardt, Reinhard Edmund Voll, Sabine Bartel, Hubert Kalbacher, Johan Hoebeke, Robert Rejdak, Folkert Horn, Gerd Wallukat, Rudolf Kunze, Martin Herrmann
Glaucoma is a frequent ocular disease that may lead to blindness. Primary open-angle glaucoma (POAG) and ocular hypertension (OHT) are common diseases with increased intraocular pressure (IOP), which are mainly responsible for these disorders. Their pathogenesis is widely unknown. We screened the sera of patients with POAG and OHT for the prevalence of autoantibodies (AAb) against G protein-coupled receptors (GPCRs) in comparison to controls. Employing frequency modulation of spontaneously contracting neonatal rat cardiomyocytes in vitro , agonistic GPCR AAb were to be detected in roughly 75% of the patients with POAG and OHT, however, not in controls...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29368640/co-localization-of-lymphoid-aggregates-and-lymphatic-networks-in-nose-nalt-and-lacrimal-duct-associated-lymphoid-tissue-ldalt-of-mice
#4
Melanie Lohrberg, Reinhard Pabst, Jörg Wilting
BACKGROUND: The lymphatic vascular pattern in the head of mice has rarely been studied, due to problems of sectioning and immunostaining of complex bony structures. Therefore, the association of head lymphoid tissues with the lymphatics has remained unknown although the mouse is the most often used species in immunology. RESULTS: Here, we studied the association of nasal and nasolacrimal duct lymphatics with lymphoid aggregates in 14-day-old and 2-month-old mice...
January 25, 2018: BMC Immunology
https://www.readbyqxmd.com/read/28878627/optic-nerve-degeneration-after-retinal-ischemia-reperfusion-in-a-rodent-model
#5
Marina Renner, Gesa Stute, Mohammad Alzureiqi, Jacqueline Reinhard, Susanne Wiemann, Heiko Schmid, Andreas Faissner, H Burkhard Dick, Stephanie C Joachim
Retinal ischemia is a common pathomechanism in many ocular disorders such as age-related macular degeneration (AMD), diabetic retinopathy, glaucoma or retinal vascular occlusion. Several studies demonstrated that ischemia/reperfusion (I/R) leads to morphological and functional changes of different retinal cell types. However, little is known about the ischemic effects on the optic nerve. The goal of this study was to evaluate these effects. Ischemia was induced by raising the intraocular pressure (IOP) in one eye of rats to 140 mmHg for 1 h followed by natural reperfusion...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28831559/-ophthalmological-health-care-of-the-institutionalized-elderly-the-ovis-study
#6
P P Fang, A Schnetzer, D G Kupitz, A P Göbel, T Kohnen, T Reinhard, B Lorenz, H Hoerauf, L Wagenfeld, G Auffarth, F Schaub, H Thieme, B von Livonius, F Alten, A Robering, C Brandl, F Ziemssen, F Krummenauer, F G Holz, R P Finger
BACKGROUND: Due to demographic change and societal transformation the number of elderly persons living in retirement homes is growing in Germany. Access to health care is more complicated in the setting of nursing homes. Different regional studies suggest unmet ophthalmological health care needs in institutionalized elderly people. This study assessed the current ophthalmological health care structure and supply status in nursing homes in Germany. METHODS: This prospective, multicenter cross-sectional study was conducted by 14 study centers in Germany...
September 2017: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/28378048/-new-biomaterials-and-alternative-stem-cell-sources-for-the-reconstruction-of-the-limbal-stem-cell-niche
#7
REVIEW
P Eberwein, T Reinhard
Reconstruction of the limbal stem cell niche in patients with limbal stem cell insufficiency remains one of the most challenging tasks in the treatment of ocular surface diseases. Ex vivo expansion of limbal stem cells still has potential for optimization despite positive reports in centers worldwide. New biomaterials as well as alternative cell sources for the reconstruction of the limbal stem cell niche have been published in recent years. The aim of this review is to provide insight into new biomaterials and cell sources which may find their way into clinical routine in the upcoming decades...
April 2017: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/28361356/-pathophysiology-of-atopic-blepharokeratoconjunctivitis
#8
T Lapp, P Maier, T Jakob, T Reinhard
Atopic dermatitis (AD) is a systemic inflammatory disease, which is characterized by pronounced eczema and pruritus. In addition to the involvement of the entire integument, the periocular lid skin and the surface of the eye are frequently involved. Ocular involvement may occur solely without dermatitis of facial or body skin. Pathophysiologically, besides a dysregulated immune response, genetic changes can occur in various dermal structural proteins which will lead to a disturbed skin barrier. Furthermore, there is a regular colonization with bacterial pathogens and an increased susceptibility for viral skin infections...
June 2017: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/28283768/-ocular-involvement-in-atopic-dermatitis-clinical-aspects-and-therapy
#9
P Maier, T Lapp, T Reinhard
Patients with atopic dermatitis frequently complain of ocular symptoms. The general dermatitis can directly affect the periocular skin and patients often present with chronic atopic blepharokeratoconjunctivitis. Early diagnosis of the characteristic ophthalmological alterations, such as blepharitis, allergic conjunctivitis, keratoconjunctivitis sicca, conjunctival scarring with formation of symblepharon and lid malpositioning, filiform keratitis, corneal plaques, (persistent) epithelial defects, corneal ulcers and keratoconus as well as appropriate stage-adapted treatment, including lid hygiene with preservative-free lubricants, topical and sometimes systemic anti-inflammatory therapy and surgical treatment are important for patients to prevent long-term damage of the ocular surface leading to severe visual impairment...
June 2017: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/27545668/sonographic-changes-in-optic-nerve-sheath-diameter-associated-with-supra-versus-infrarenal-aortic-aneurysm-repair
#10
Michael Ertl, Wilma Schierling, Piotr M Kasprzak, Reinhard Kopp, Corinna Brückl, Felix Schlachetzki, Karin Pfister
BACKGROUND AND PURPOSE: Quantification of changes in optic nerve sheath diameter (ONSD) using ocular sonography (OS) constitutes an elegant technique for estimating intracranial and intraspinal pressure. Aortic aneurysm repair (AAR) is associated with a reasonable risk of increased spinal fluid pressure, which is largely dependent on the extent of aneurysm repair (supra- vs. infrarenal). The aim of this study was to compare ONSD measurements in patients with suprarenal AAR (sAAR) or infrarenal AAR (iAAR)...
March 2017: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
https://www.readbyqxmd.com/read/27492110/cataract-in-pseudohypoparathyroidism
#11
Rafael S Grajewski, Konrad R Koch, Hans-Reinhard Koch, Iulia M Ciotu, Claus Cursiefen, Ludwig M Heindl
UNLABELLED: A 22-year-old white man presented with photopsia of 3-year duration despite a corrected distance visual acuity of 20/20 in both eyes. Ophthalmic examination revealed multiple irregularly shaped white cortical opacifications of the lens in both eyes but no other significant ocular findings. One year after the photopsia onset, the patient experienced an episode of seizures with generalized tonic-clonic movements. Neurological follow-up examination demonstrated extensive brain calcification in the basal ganglia and frontal lobes, leading to a diagnosis of pseudohypoparathyroidism...
July 2016: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/27374750/early-remodelling-of-the-extracellular-matrix-proteins-tenascin-c-and-phosphacan-in-retina-and-optic-nerve-of-an-experimental-autoimmune-glaucoma-model
#12
Sabrina Reinehr, Jacqueline Reinhard, Susanne Wiemann, Gesa Stute, Sandra Kuehn, Julia Woestmann, H Burkhard Dick, Andreas Faissner, Stephanie C Joachim
Glaucoma is characterized by the loss of retinal ganglion cells (RGCs) and optic nerve fibres. Previous studies noted fewer RGCs after immunization with ocular antigens at 28 days. It is known that changes in extracellular matrix (ECM) components conduct retina and optic nerve degeneration. Here, we focused on the remodelling of tenascin-C and phosphacan/receptor protein tyrosine phosphatase β/ζ in an autoimmune glaucoma model. Rats were immunized with optic nerve homogenate (ONA) or S100B protein (S100)...
November 2016: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/27272842/expansive-extracranial-growth-of-intracranial-meningioma-in-neurofibromatosis-type-2
#13
Reinhard E Friedrich, Christian Hagel
The purpose of this report is to detail three rare cases of neurofibromatosis type 2 (NF2) with symptomatic extracranial extension of intracranial meningioma. We present ocular findings, imaging techniques applied, pathological findings of the space-occupying lesions, and therapy. One of these patients, the daughter of one of the other individuals, presented with a large neck mass, but no surgically treatable findings associated with the external growth of the meningioma. The patients complained of symptoms associated with the extracranial portion of the intracranial meningioma, rather than of the intracranial primaries...
June 2016: Anticancer Research
https://www.readbyqxmd.com/read/27084345/neurological-respiratory-musculoskeletal-cardiac-and-ocular-side-effects-of-anti-pd-1-therapy
#14
MULTICENTER STUDY
Lisa Zimmer, Simone M Goldinger, Lars Hofmann, Carmen Loquai, Selma Ugurel, Ioannis Thomas, Maria I Schmidgen, Ralf Gutzmer, Jochen S Utikal, Daniela Göppner, Jessica C Hassel, Friedegund Meier, Julia K Tietze, Andrea Forschner, Carsten Weishaupt, Martin Leverkus, Renate Wahl, Ursula Dietrich, Claus Garbe, Michael C Kirchberger, Thomas Eigentler, Carola Berking, Anja Gesierich, Angela M Krackhardt, Dirk Schadendorf, Gerold Schuler, Reinhard Dummer, Lucie M Heinzerling
BACKGROUND: Anti-programmed cell death 1 (PD-1) antibodies represent an effective treatment option for metastatic melanoma and other cancer entities. They act via blockade of the PD-1 receptor, an inhibitor of the T-cell effector mechanisms that limit immune responses against tumours. As reported for ipilimumab, the anti-PD-1 antibodies pembrolizumab and nivolumab can induce immune-related adverse events (irAEs). These side-effects can involve skin, gastrointestinal tract, liver, the endocrine system and other organ systems...
June 2016: European Journal of Cancer
https://www.readbyqxmd.com/read/27031838/total-retinal-blood-flow-in-a-nonhuman-primate-optic-nerve-transection-model-using-dual-beam-bidirectional-doppler-fd-oct-and-microsphere-method
#15
Reinhard Told, Lin Wang, Grant Cull, Simon J Thompson, Claude F Burgoyne, Gerold C Aschinger, Leopold Schmetterer, René M Werkmeister
PURPOSE: We validated noninvasive Doppler-optical coherence tomography (OCT) blood flow measurements against the terminal microsphere method in a surgical induced optic nerve transection nonhuman primate model. METHODS: In 6 nonhuman primates, total retinal blood flow (TRBF) was measured with a custom-built dual-beam bidirectional Doppler Fourier Domain (FD)-OCT. Peripapillary retinal nerve fiber layer thickness (RNFLT) was measured by Spectralis spectral-domain (SD)-OCT...
March 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/26966641/normal-values-for-the-full-visual-field-corrected-for-age-and-reaction-time-using-semiautomated-kinetic-testing-on-the-octopus-900-perimeter
#16
Julia Grobbel, Janko Dietzsch, Chris A Johnson, Reinhard Vonthein, Katarina Stingl, Richard G Weleber, Ulrich Schiefer
PURPOSE: To determine normal values of the visual field (VF), corrected for age and reaction time (RT) for semiautomated kinetic perimetry (SKP) on the Octopus 900 perimeter, create a model describing the age-dependency of these values, and assess test-retest reliability for each isopter. METHODS: Eighty-six eyes of 86 ophthalmologically healthy subjects (age 11-79 years, 34 males, 52 females) underwent full-field kinetic perimetry with the Octopus 900 instrument...
March 2016: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/26961680/identification-of-two-novel-mutations-in-the-cornea-specific-tgfbi-gene-causing-unique-phenotypes-in-patients-with-corneal-dystrophies
#17
Sabine Foja, Katrin Hoffmann, Claudia Auw-Haedrich, Thomas Reinhard, Andreas Rupprecht, Claudia Gruenauer-Kloevekorn
The purpose of this study was to report on two novel missense mutations of the cornea-specific TGFBI gene in one single patient and in two generations of a family diagnosed with unique corneal dystrophy (CD) phenotypes. Ophthalmologic examination, in several cases ocular coherence tomography of the anterior segment (AS-OCT), was performed in 21 affected patients and in two unaffected members of one affected family. Coding regions of the TGFBI gene were direct sequenced in all 23 individuals. The two novel mutations were verified by RFLP analysis...
December 2016: International Ophthalmology
https://www.readbyqxmd.com/read/26886206/clinical-features-pathogenesis-and-treatment-of-myasthenia-gravis-a-supplement-to-the-guidelines-of-the-german-neurological-society
#18
REVIEW
Nico Melzer, Tobias Ruck, Peter Fuhr, Ralf Gold, Reinhard Hohlfeld, Alexander Marx, Arthur Melms, Björn Tackenberg, Berthold Schalke, Christiane Schneider-Gold, Fritz Zimprich, Sven G Meuth, Heinz Wiendl
Myasthenia gravis (MG) is an autoimmune antibody-mediated disorder of neuromuscular synaptic transmission. The clinical hallmark of MG consists of fluctuating fatigability and weakness affecting ocular, bulbar and (proximal) limb skeletal muscle groups. MG may either occur as an autoimmune disease with distinct immunogenetic characteristics or as a paraneoplastic syndrome associated with tumors of the thymus. Impairment of central thymic and peripheral self-tolerance mechanisms in both cases is thought to favor an autoimmune CD4(+) T cell-mediated B cell activation and synthesis of pathogenic high-affinity autoantibodies of either the IgG1 and 3 or IgG4 subclass...
August 2016: Journal of Neurology
https://www.readbyqxmd.com/read/26618350/noncutaneous-melanomas-a-single-center-analysis
#19
Valerio Del Prete, Karla Chaloupka, David Holzmann, Daniel Fink, Mitchell Levesque, Reinhard Dummer, Simone M Goldinger
BACKGROUND: The optimal treatment algorithm for noncutaneous melanomas must yet be established. OBJECTIVE: To compare systemic treatment-relevant mutational status, metastatic pattern and response to systemic treatment in noncutaneous melanoma. METHODS: Retrospective single-center study analyzing 64 noncutaneous melanoma patients treated between January 2006 and September 2013. RESULTS: c-KIT mutations were found exclusively in vulvovaginal melanoma (4/7)...
2016: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/26588253/hypertrophic-olivary-degeneration-a-neurosurgical-point-of-view
#20
REVIEW
Carlos Henrique Carvalho, Hubert Kimmig, William Omar Contreras Lopez, Manfred Lange, Reinhard Oeckler
Hypertrophic olivary degeneration (HOD) is a rare form of transsynaptic degeneration characterized by hypertrophy of the inferior olivary nucleus situated in the olivary body, part of the medulla oblongata, representing a major source of input to the cerebellum. HOD typically results from focal lesions interrupting connections from the inferior olive within the dentato-rubro-olivary pathway, a region also known as the triangle of Guillain-Mollaret (TGM) (red nucleus, inferior olivary nucleus, and contralateral dentate nucleus)...
January 2016: Journal of Neurological Surgery. Part A, Central European Neurosurgery
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