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https://www.readbyqxmd.com/read/28439579/severe-tooth-wear-european-consensus-statement-on-management-guidelines
#1
Bas Loomans, Niek Opdam, Thomas Attin, David Bartlett, Daniel Edelhoff, Roland Frankenberger, Goran Benic, Simon Ramseyer, Peter Wetselaar, Bernadette Sterenborg, Reinhard Hickel, Ulla Pallesen, Shamir Metha, Subir Banerji, Adrian Lussi, Nairn Wilson
This paper presents European expert consensus guidelines on the management of severe tooth wear. It focuses on the definition of physiological vs pathological tooth wear and recommends diagnosis, prevention, counseling, and monitoring aimed at elucidating the etiology, nature, rate and means of controlling pathological tooth wear. Management decisions are multifactorial, depending principally on the severity and effects of the wear and the wishes of the patient. Restorative intervention is typically best delayed as long as possible...
April 21, 2017: Journal of Adhesive Dentistry
https://www.readbyqxmd.com/read/28438646/assessment-of-a-revised-wartime-experiences-scale-for-vietnam-era-women-the-health-of-vietnam-era-women-s-study-healthviews
#2
Lisa Marie Sternke, Tracey Serpi, Avron Spiro, Rachel Kimerling, Amy M Kilbourne, Yasmin Cypel, Susan M Frayne, Joan Furey, Grant D Huang, Matthew J Reinhard, Kathryn Magruder
PURPOSE: Few wartime experiences scales capture unique issues related to women's service, address their military roles, or have been validated with women. The Women's Wartime Stressor Scale was developed for use with women who served during the Vietnam era, primarily as nurses in Vietnam. We revised this measure by modifying existing items, adding new items, and revising response formats to create a scale less nursing specific and nondeployment specific, and conducted a preliminary assessment of the revised scale...
April 21, 2017: Women's Health Issues: Official Publication of the Jacobs Institute of Women's Health
https://www.readbyqxmd.com/read/28432991/characteristics-of-adapted-hydrogenotrophic-community-during-biomethanation
#3
Lydia Rachbauer, Reinhard Beyer, Günther Bochmann, Werner Fuchs
The results presented in this study were carried out as concomitant experiments during the start-up and operation of a biomethanation unit to evaluate the effect of process parameters on carbon conversion, product formation (methane and acetate) and community composition. For that, two different samples were withdrawn from a trickle-bed reactor with immobilized enrichment culture of hydrogenotrophic methanogens adapted from sewage sludge. One sample was taken from the recirculation liquid during start-up phase while the other was withdrawn directly from the carrier material in the reactor...
April 19, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28432976/cuticular-wax-coverage-and-composition-differ-among-organs-of-taraxacum-officinale
#4
Yanjun Guo, Lucas Busta, Reinhard Jetter
Primary plant surfaces are coated with hydrophobic cuticular waxes to minimize non-stomatal water loss. Wax compositions differ greatly between plant species and, in the few species studied systematically so far, also between organs, tissues, and developmental stages. However, the wax mixtures of more species in diverse plant families must be investigated to assess overall wax variability, and ultimately to correlate organ-specific composition with local water barrier properties. Here, we present comprehensive analyses of the waxes covering five organs of Taraxacum officinale (dandelion), to help close a gap in our understanding of wax chemistry in the Asteraceae family...
April 6, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/28431546/health-care-public-reporting-utilization-user-clusters-web-trails-and-usage-barriers-on-germany-s-public-reporting-portal-weisse-liste-de
#5
Christoph Pross, Lars-Henrik Averdunk, Josip Stjepanovic, Reinhard Busse, Alexander Geissler
BACKGROUND: Quality of care public reporting provides structural, process and outcome information to facilitate hospital choice and strengthen quality competition. Yet, evidence indicates that patients rarely use this information in their decision-making, due to limited awareness of the data and complex and conflicting information. While there is enthusiasm among policy makers for public reporting, clinicians and researchers doubt its overall impact. Almost no study has analyzed how users behave on public reporting portals, which information they seek out and when they abort their search...
April 21, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/28426733/mini-g-proteins-novel-tools-for-studying-gpcrs-in-their-active-conformation
#6
Rony Nehmé, Byron Carpenter, Ankita Singhal, Annette Strege, Patricia C Edwards, Courtney F White, Haijuan Du, Reinhard Grisshammer, Christopher G Tate
Mini-G proteins are the engineered GTPase domains of Gα subunits. They couple to GPCRs and recapitulate the increase in agonist affinity observed upon coupling of a native heterotrimeric G protein. Given the small size and stability of mini-G proteins, and their ease of expression and purification, they are ideal for biophysical studies of GPCRs in their fully active state. The first mini-G protein developed was mini-Gs. Here we extend the family of mini-G proteins to include mini-Golf, mini-Gi1, mini-Go1 and the chimeras mini-Gs/q and mini-Gs/i...
2017: PloS One
https://www.readbyqxmd.com/read/28425919/cell-behavior-of-human-mesenchymal-stromal-cells-in-response-to-silica-collagen-based-xerogels-and-calcium-deficient-culture-conditions
#7
Alena Wagner, Kristina Glenske, Anja Henß, Benjamin Kruppke, Sina Rößler, Thomas Hanke, Andreas Moritz, Marcus Rohnke, Monika Kressin, Stefan Arnhold, Reinhard Schnettler, Sabine Wenisch
Presently, we aim to elucidate osteogenic effects of two silica-based xerogels with different degrees of bioactivity on human bone-derived mesenchymal stromal cells. By means of scanning electron microscopy and quantitative PCR enhanced osteogenic effects and the formation of an extracellular matrix could be ascribed to the sample with lower bioactivity. Given the high levels of bioactivity, the cells revealed remarkable sensitivity to extremely low calcium levels of the media. Therefore, additional experiments were performed to elucidate cell behavior under calcium deficient conditions...
April 20, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28425162/a-small-lick-will-sink-a-great-ship-fulminant-septicaemia-after-dog-saliva-wound-treatment-in-an-asplenic-patient
#8
Evi M Morandi, Reinhard Pauzenberger, Christoph Tasch, Ulrich M Rieger, Gerhard Pierer, Gabriel Djedovic
Capnocytophaga canimorsus is a bacterium transmitted through the saliva of dogs. An infection can cause severe sepsis with acral necrosis and is potentially fatal. Here, we report the case of a 41-year-old man who was infected through a wound that was licked by his dog. He went into septic shock with disseminated intravascular coagulation and subsequently lost both lower legs, his nose and all the fingers on both hands.
April 19, 2017: International Wound Journal
https://www.readbyqxmd.com/read/28422359/clinical-evaluation-of-indirect-particle-filled-composite-resin-cad-cam-partial-crowns-after-24-months
#9
Moritz Zimmermann, Christina Koller, Marcel Reymus, Albert Mehl, Reinhard Hickel
PURPOSE: Resin-based CAD/CAM compound materials might be promising for single-tooth restorations. Insufficient clinical data are available for this new material class. The purpose of this study was to describe initial clinical in vivo results for indirect particle-filled composite resin CAD/CAM restorations after 24 months. MATERIALS AND METHODS: Indirect particle-filled composite resin restorations were fabricated with a CAD/CAM method (CEREC Bluecam intraoral scanner, CEREC MCXL milling unit) by calibrated dental students...
April 19, 2017: Journal of Prosthodontics: Official Journal of the American College of Prosthodontists
https://www.readbyqxmd.com/read/28421637/a-new-approach-to-models-of-the-4-5-dihydroxycyclopentenone-core-of-the-kodaistatins-a-d-elucidation-of-the-diol-configuration-in-kodaistatin-a
#10
Reinhard Brückner, David Peter
The kodaistatins are natural products from Aspergillus terreus. Being strongly anti-diabetic they hold some promise of a novel diabetes cure. However, considerations of that kind face two drawbacks. (1) The kodaistatins contain a heavily substituted pulvinone/cyclopentenone combination. (2) The kodaistatins are 1,2-diols, whose 3D structure have not been assigned yet. However, we can exclude two of the four possible stereostructures. We conclude that kodaistatin A is a trans-, not a cis-diol, from NMR comparisons with a pair of cis,trans-isomeric kodaistatin models, which we synthesized in 11 and 12 steps, respectively...
April 18, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28420120/clinical-outcomes-of-217-patients-with-acute-erythroleukemia-according-to-treatment-type-and-line-a-retrospective-multinational-study
#11
Antonio M Almeida, Thomas Prebet, Raphael Itzykson, Fernando Ramos, Haifa Al-Ali, Jamile Shammo, Ricardo Pinto, Luca Maurillo, Jaime Wetzel, Pellegrino Musto, Arjan A Van De Loosdrecht, Maria Joao Costa, Susana Esteves, Sonja Burgstaller, Reinhard Stauder, Eva M Autzinger, Alois Lang, Peter Krippl, Dietmar Geissler, Jose Francisco Falantes, Carmen Pedro, Joan Bargay, Guillermo Deben, Ana Garrido, Santiago Bonanad, Maria Diez-Campelo, Sylvain Thepot, Lionel Ades, Wolfgang R Sperr, Peter Valent, Pierre Fenaux, Mikkael A Sekeres, Richard Greil, Lisa Pleyer
Acute erythroleukemia (AEL) is a rare disease typically associated with a poor prognosis. The median survival ranges between 3-9 months from initial diagnosis. Hypomethylating agents (HMAs) have been shown to prolong survival in patients with myelodysplastic syndromes (MDS) and AML, but there is limited data of their efficacy in AEL. We collected data from 210 AEL patients treated at 28 international sites. Overall survival (OS) and PFS were estimated using the Kaplan-Meier method and the log-rank test was used for subgroup comparisons...
April 14, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28418704/false-negatives-for-remote-life-detection-on-ocean-bearing-planets-lessons-from-the-early-earth
#12
Christopher T Reinhard, Stephanie L Olson, Edward W Schwieterman, Timothy W Lyons
Ocean-atmosphere chemistry on Earth has undergone dramatic evolutionary changes throughout its long history, with potentially significant ramifications for the emergence and long-term stability of atmospheric biosignatures. Though a great deal of work has centered on refining our understanding of false positives for remote life detection, much less attention has been paid to the possibility of false negatives, that is, cryptic biospheres that are widespread and active on a planet's surface but are ultimately undetectable or difficult to detect in the composition of a planet's atmosphere...
April 2017: Astrobiology
https://www.readbyqxmd.com/read/28418677/ph-dependence-of-ferricytochrome-c-conformational-transitions-during-binding-to-cardiolipin-membranes-evidence-for-histidine-as-the-distal-ligand-at-neutral-ph
#13
Bridget Milorey, Dmitry Malyshka, Reinhard Schweitzer-Stenner
The conformational changes of ferricytochrome c upon binding to cardiolipin-containing small unilamellar vesicles were studied at slightly acidic pH using fluorescence, visible circular dichroism, UV-visible absorption, and resonance Raman spectroscopy. The obtained spectroscopic response data suggest a mode of interaction, which is clearly distinct from the binding process observed at neutral pH. Evidence of a reversible and electrostatic binding mechanism under these conditions is provided through binding inhibition in the presence of 150 mM NaCl...
April 24, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28416715/t-cell-transfer-experimental-autoimmune-encephalomyelitis-pillar-of-multiple-sclerosis-and-autoimmunity
#14
Reinhard Hohlfeld, Lawrence Steinman
No abstract text is available yet for this article.
May 1, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28414428/low-temperature-trapping-of-intermediates-in-the-reaction-of-no-%C3%A2-with-o2
#15
Leila Mahmoudi, Reinhard Kissner, Willem H Koppenol
The autoxidation of NO(•) was studied in glass-like matrices of 2-methylbutane at 110 K and in a 8:3 v/v mixture of 2,2-dimethylbutane and n-pentane (rigisolve) at 80-90 K, by letting gaseous NO(•) diffuse into these solvents that were saturated with O2. In 2-methyllbutane, we observed a red compound. However, in rigisolve at 85-90 K, a bright yellow color appears that turns red when the sample is warmed by 10-20 K. The new yellow compound is a precursor of the red one and also diamagnetic. The UV-vis spectrum of the yellow compound contains a band which resembles that present in ONOO(-)...
April 17, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28412435/cmr-derived-extracellular-volume-fraction-as-a-marker%C3%A2-for-myocardial-fibrosis-the-importance-of-coexisting-myocardial-inflammation
#16
Julia Anna Lurz, Christian Luecke, David Lang, Christian Besler, Karl-Philipp Rommel, Karin Klingel, Reinhard Kandolf, Volker Adams, Katharina Schöne, Gerhard Hindricks, Gerhard Schuler, Axel Linke, Holger Thiele, Matthias Gutberlet, Philipp Lurz
OBJECTIVES: The aim of the present study was to evaluate whether extracellular volume fraction (ECV) can reliably inform on the extent of diffuse fibrosis in the simultaneous presence of myocardial inflammation, which has not been verified to date. BACKGROUND: Diffuse myocardial fibrosis is associated with unfavorable outcome in patients with cardiomyopathy, and is of prognostic relevance. Assessment of ECV bears promise for being a noninvasive surrogate parameter, but it may be altered by other pathologies...
April 7, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28411193/liver-metastasis-and-treatment-outcome-with-anti-pd-1-monoclonal-antibody-in-patients-with-melanoma-and-nsclc
#17
Paul C Tumeh, Matthew D Hellmann, Omid Hamid, Katy K Tsai, Kimberly L Loo, Matthew A Gubens, Michael Rosenblum, Christina L Harview, Janis Taube, Nathan Handley, Neharika Khurana, Adi Nosrati, Matthew F Krummel, Andrew Tucker, Eduardo Sosa, Philip J Sanchez, Nooriel Banayan, Juan Osorio, Dan L Nguyen-Kim, Jeremy Chang, I Peter Shintaku, Peter Boasberg, Emma J Taylor, Pamela N Munster, Alain P Algazi, Bartosz Chmielowski, Reinhard Dummer, Tristan R Grogan, David A Elashoff, Jimmy Hwang, Simone Goldinger, Edward Garon, Robert H Pierce, Adil I Daud
We explored the association between liver metastases, tumor CD8+ T cell count, and response in patients with melanoma or lung cancer treated with the anti-PD-1 antibody, pembrolizumab. The melanoma discovery cohort was drawn from the Phase I Keynote 001 trial, whereas the melanoma validation cohort was drawn from Keynote 002, 006, and EAP trials and the non-small cell lung cancer (NSCLC) cohort from Keynote 001. Liver metastasis was associated with reduced response and shortened progression-free survival (PFS); [objective response rate (ORR), 30...
April 14, 2017: Cancer Immunology Research
https://www.readbyqxmd.com/read/28410286/successful-treatment-with-imatinib-after-nilotinib-and-ipilimumab-in-a-c-kit-mutated-advanced-melanoma-patient-a-case-report
#18
Carla Murer, Pascale Kränzlin-Stieger, Lars E French, Reinhard Dummer, Simone M Goldinger
Treatment of melanoma remains a challenge in advanced disease. Recently, the molecular differentiation in BRAF-mutated, NRAS-mutated and c-kit-mutated melanomas led to new treatment strategies. Different trials show that imatinib or nilotinib lead to meaningful responses in c-kit-mutated melanoma patients. There are little published data on sequential inhibition using these two drugs in melanoma. We describe the sequential use of imatinib after nilotinib in a c-kit-mutated melanoma patient, who progressed on interferon, Allovectin, dacarbazine, nilotinib and ipilimumab, and was finally treated with the c-kit inhibitor imatinib...
April 13, 2017: Melanoma Research
https://www.readbyqxmd.com/read/28409636/signal-on-photoelectrochemical-immunoassay-for-aflatoxin-b1-based-on-enzymatic-product-etching-mno2-nanosheets-for-dissociation-of-carbon-dots
#19
Youxiu Lin, Qian Zhou, Dianping Tang, Reinhard Niessner, Dietmar Knopp
Aflatoxin B1 (AFB1) monitoring has attracted extensive attention because food safety is a worldwide public health problem. Herein, we design a novel simultaneously visual and photoelectrochemical (PEC) immunosensing system for rapid sensitive detection of AFB1 in foodstuff. The immunoreaction was carried out on anti-AFB1 antibody-modified magnetic beads by using glucose oxidase (GOx)-labeled AFB1-bovine serum albumin (AFB1-BSA) conjugates as the tags with a competitive-type immunoassay format, while the visual and PEC evaluation was performed via carbon quantum dots (CQDs)-functionalized MnO2 nanosheets...
April 14, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28407638/improvement-of-stress-resistance-and-quality-of-life-of-adults-with-nervous-restlessness-after-treatment-with-a-passion-flower-dry-extract
#20
Judith Gibbert, Fabian Kreimendahl, Jennifer Lebert, Reinhard Rychlik, Inga Trompetter
No abstract text is available yet for this article.
April 12, 2017: Complementary Medicine Research
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