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John Kanellopoulos

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https://www.readbyqxmd.com/read/27843292/topography-modified-refraction-tmr-adjustment-of-treated-cylinder-amount-and-axis-to-the-topography-versus-standard-clinical-refraction-in-myopic-topography-guided-lasik
#1
Anastasios John Kanellopoulos
PURPOSE: To evaluate the safety, efficacy, and contralateral eye comparison of topography-guided myopic LASIK with two different refraction treatment strategies. SETTING: Private clinical ophthalmology practice. PATIENTS AND METHODS: A total of 100 eyes (50 patients) in consecutive cases of myopic topography-guided LASIK procedures with the same refractive platform (FS200 femtosecond and EX500 excimer lasers) were randomized for treatment as follows: one eye with the standard clinical refraction (group A) and the contralateral eye with the topographic astigmatic power and axis (topography-modified treatment refraction; group B)...
2016: Clinical Ophthalmology
https://www.readbyqxmd.com/read/27478858/standard-manual-capsulorhexis-ultrasound-phacoemulsification-compared-to-femtosecond-laser-assisted-capsulorhexis-and-lens-fragmentation-in-clear-cornea-small-incision-cataract-surgery
#2
Anastasios John Kanellopoulos, George Asimellis
BACKGROUND: Femtosecond-laser assisted clear cornea cataract surgery may hold promise in safer and more effective procedures. We decided to perform a comparative study to standard manual incision phacoemulsification surgery. METHODS: This is a single-center, single-intervention, and prospective comparative data evaluation of 133 consecutive cases subjected to cataract surgery. Group-A (Phaco), manual capsulorhexis & ultrasound phacoemulsification (n = 66); Group-B femtosecond-laser assisted capsulorhexis and lens fragmentation (n = 67), employing the LenSx laser (Alcon Surgical, Ft...
2016: Eye and Vision (London, England)
https://www.readbyqxmd.com/read/27255249/nanosecond-laser-assisted-cataract-surgery-endothelial-cell-study
#3
Ivan Tanev, Vesselin Tanev, Anastasios John Kanellopoulos
PURPOSE: To evaluate corneal endothelial cell density (ECD) and morphology after cataract surgery using coaxial ultrasound (US) phacoemulsification or a recently introduced coaxial nanosecond laser technique. SETTING: Department of Ophthalmology, Medical University of Sofia, Sofia, Bulgaria. DESIGN: Prospective cohort study. METHODS: Coaxial US phacoemulsification was performed in 1 eye (US group) and coaxial nanosecond laser-assisted cataract surgery in the contralateral eye (laser group) of the same patient...
May 2016: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/26921291/prognostic-implication-of-the-absolute-lymphocyte-to-absolute-monocyte-count-ratio-in-patients-with-classical-hodgkin-lymphoma-treated-with-doxorubicin-bleomycin-vinblastine-and-dacarbazine-or-equivalent-regimens
#4
Theodoros P Vassilakopoulos, Maria N Dimopoulou, Maria K Angelopoulou, Kyriaki Petevi, Gerassimos A Pangalis, Maria Moschogiannis, Maria Dimou, George Boutsikas, Alexandros Kanellopoulos, Gabriella Gainaru, Eleni Plata, Pagona Flevari, Katerina Koutsi, Loula Papageorgiou, Vassilios Telonis, Panayiotis Tsaftaridis, Sotirios Sachanas, Xanthoula Yiakoumis, Pantelis Tsirkinidis, Nora-Athina Viniou, Marina P Siakantaris, Eleni Variami, Marie-Christine Kyrtsonis, John Meletis, Panayiotis Panayiotidis, Kostas Konstantopoulos
Low absolute lymphocyte count (ALC) to absolute monocyte count (AMC) ratio (ALC/AMC) is an independent prognostic factor in Hodgkin lymphoma (HL), but different cutoffs (1.1, 1.5, and 2.9) have been applied. We aimed to validate the prognostic significance of ALC/AMC in 537 homogenously treated (doxorubicin, bleomycin, vinblastine, and dacarbazine or equivalents ± radiotherapy) classical HL patients at various cutoffs. The median ALC/AMC was 2.24 (0.44-20.50). The median AMC was 0.653 × 10(9)/L (0.050-2.070)...
March 2016: Oncologist
https://www.readbyqxmd.com/read/26909354/higher-incidence-of-steroid-induced-ocular-hypertension-in-keratoconus
#5
Anastasios John Kanellopoulos, Emerson M Cruz, Robert Edward T Ang, George Asimellis
BACKGROUND: To compare intraocular pressure (IOP) changes following topical dexamethasone administration for 1 month in keratoconic versus normal eyes. METHODS: This is a retrospective, single-center, non-randomized case series evaluation of 350 eyes. Two groups were formed: normal/control Group A (nA =73), eyes that underwent excimer laser photorefractive keratectomy; and keratoconic (KCN) Group B (nB =277), eyes that were subjected to partial laser photorefractive keratectomy combined with collagen cross-linking (The Athens Protocol)...
2016: Eye and Vision (London, England)
https://www.readbyqxmd.com/read/26783543/in-pursuit-of-objective-dry-eye-screening-clinical-techniques
#6
REVIEW
Anastasios John Kanellopoulos, George Asimellis
Dry eye is a multifactorial, progressive, and chronic disease of the tears and ocular surface. The disease is multi-factorial and has intermittent symptoms. Discomfort, visual disturbance, tear film instability with potential damage to the ocular surface, and increased tear film osmolarity are known associates. Dry eye is a common clinical problem for eye-care providers worldwide and there is a large number of clinical investigative techniques for the evaluation of dry eye. Despite this, however, there is no globally accepted guideline for dry eye diagnosis and none of the available tests may hold the title of the 'gold standard'...
2016: Eye and Vision (London, England)
https://www.readbyqxmd.com/read/26634308/endogenous-opioids-contribute-to-insensitivity-to-pain-in-humans-and-mice-lacking-sodium-channel-nav1-7
#7
Michael S Minett, Vanessa Pereira, Shafaq Sikandar, Ayako Matsuyama, Stéphane Lolignier, Alexandros H Kanellopoulos, Flavia Mancini, Gian D Iannetti, Yury D Bogdanov, Sonia Santana-Varela, Queensta Millet, Giorgios Baskozos, Raymond MacAllister, James J Cox, Jing Zhao, John N Wood
Loss-of-function mutations in the SCN9A gene encoding voltage-gated sodium channel Nav1.7 cause congenital insensitivity to pain in humans and mice. Surprisingly, many potent selective antagonists of Nav1.7 are weak analgesics. We investigated whether Nav1.7, as well as contributing to electrical signalling, may have additional functions. Here we report that Nav1.7 deletion has profound effects on gene expression, leading to an upregulation of enkephalin precursor Penk mRNA and met-enkephalin protein in sensory neurons...
December 4, 2015: Nature Communications
https://www.readbyqxmd.com/read/26603417/september-consultation-5
#8
COMMENT
A John Kanellopoulos
No abstract text is available yet for this article.
September 2015: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/26546965/is-the-inflammasome-relevant-for-epithelial-cell-function
#9
Patricia T Santana, Jan Martel, Hsin-Chih Lai, Jean-Luc Perfettini, Jean M Kanellopoulos, John D Young, Robson Coutinho-Silva, David M Ojcius
Inflammasomes are intracellular protein complexes that sense microbial components and damage of infected cells. Following activation by molecules released by pathogens or injured cells, inflammasomes activate caspase-1, allowing secretion of the pro-inflammatory cytokines IL-1β and IL-18 from innate immune cells. Inflammasomes are also expressed in epithelial cells, where their function has attracted less attention. Nonetheless, depending on the tissue, epithelial inflammasomes can mediate inflammation, wound healing, and pain sensitivity...
February 2016: Microbes and Infection
https://www.readbyqxmd.com/read/26544565/novel-placido-derived-topography-guided-excimer-corneal-normalization-with-cyclorotation-adjustment-enhanced-athens-protocol-for-keratoconus
#10
COMPARATIVE STUDY
Anastasios John Kanellopoulos, George Asimellis
PURPOSE: To comparatively investigate the efficacy of the enhanced Athens Protocol procedure guided by novel Placido-derived topography with cyclorotation compensation (the cyclorotation adjusted group) to similar cases guided by Scheimpflug-derived tomography without cyclorotation compensation (the non-cyclorotation adjusted group). METHODS: Two groups were evaluated: the cyclorotation adjusted group (n = 110 eyes) and the non-cyclorotation adjusted group (n = 110 eyes)...
November 2015: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/26352569/objective-evaluation-of-planned-versus-achieved-stromal-thickness-reduction-in-myopic-femtosecond-laser-assisted-lasik
#11
COMPARATIVE STUDY
Anastasios John Kanellopoulos, Stella Georgiadou, George Asimellis
PURPOSE: To evaluate corneal stromal thickness reduction and compare to attempted and achieved ablation depth in a consecutive case series study of myopic LASIK. METHODS: Stromal thickness reduction was retrospectively evaluated in 205 consecutive eyes of 205 patients undergoing myopic and myopic astigmatic LASIK. Anterior segment optical coherence tomography was performed preoperatively and 3 months postoperatively. Epithelial thickness remodeling was also accounted for to achieve objective stromal thickness reduction...
September 2015: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/26287881/combined-laser-in-situ-keratomileusis-and-prophylactic-high-fluence-corneal-collagen-crosslinking-for-high-myopia-two-year-safety-and-efficacy
#12
RANDOMIZED CONTROLLED TRIAL
Anastasios John Kanellopoulos, George Asimellis
PURPOSE: To evaluate the safety, efficacy, and refractive and keratometric stability of myopic femtosecond laser in situ keratomileusis (LASIK) with concurrent prophylactic high-fluence corneal collagen crosslinking (CXL) compared with the outcomes of standard femtosecond LASIK. SETTING: Private clinical practice, Athens, Greece. DESIGN: Consecutive randomized prospective comparative study. METHODS: Eyes that had myopic LASIK or myopic LASIK with concurrent high-fluence CXL were evaluated preoperatively and up to 2 years postoperatively for manifest refraction spherical equivalent (MRSE), refractive astigmatism, visual acuity, corneal keratometry (K), and endothelial cell count...
July 2015: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/26057324/distribution-and-repeatability-of-corneal-astigmatism-measurements-magnitude-and-axis-evaluated-with-color-light-emitting-diode-reflection-topography
#13
Anastasios John Kanellopoulos, George Asimellis
PURPOSE: To evaluate and investigate the distribution and repeatability of anterior corneal surface astigmatism measurements (axis and magnitude) using a novel corneal topographer. METHODS: Anterior corneal surface astigmatism was investigated in a total of 195 eyes using a novel multicolored spot reflection topographer (Cassini; i-Optics). Two patient groups were studied, a younger-age group A and an older-age group B. Three consecutive acquisitions were obtained from each eye...
August 2015: Cornea
https://www.readbyqxmd.com/read/25949993/cross-linking-and-corneal-imaging-advances
#14
EDITORIAL
A John Kanellopoulos, Ronald R Krueger, George Asimellis
No abstract text is available yet for this article.
2015: BioMed Research International
https://www.readbyqxmd.com/read/25878894/current-concepts-and-future-developments-of-corneal-cross-linking
#15
Suphi Taneri, Elias Jarade, John A Kanellopoulos, David Muller
No abstract text is available yet for this article.
2015: Journal of Ophthalmology
https://www.readbyqxmd.com/read/25840308/reshaping-procedures-for-the-surgical-management-of-corneal-ectasia
#16
REVIEW
Mohammed Ziaei, Allon Barsam, Neda Shamie, David Vroman, Terry Kim, Eric D Donnenfeld, Edward J Holland, John Kanellopoulos, Francis S Mah, J Bradley Randleman, Sheraz Daya, Jose Güell
UNLABELLED: Corneal ectasia is a progressive, degenerative, and noninflammatory thinning disorder of the cornea. Recently developed corneal reshaping techniques have expanded the treatment armamentarium available to the corneal specialist by offering effective nontransplant options. This review summarizes the current evidence base for corneal collagen crosslinking, topography-guided photorefractive keratectomy, and intrastromal corneal ring segment implantation for the treatment of corneal ectasia by analyzing the data published between the years 2000 and 2014...
April 2015: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/25795914/high-irradiance-cxl-combined-with-myopic-lasik-flap-and-residual-stroma-biomechanical-properties-studied-ex-vivo
#17
COMPARATIVE STUDY
Anastasios John Kanellopoulos, George Asimellis, Borja Salvador-Culla, James Chodosh, Joseph B Ciolino
BACKGROUND/AIMS: To evaluate ex vivo biomechanical and enzymatic digestion resistance differences between standard myopic laser in-situ keratomileusis (LASIK) compared with LASIK+CXL, in which high-irradiance cross-linking (CXL) is added. METHODS: Eight human donor corneas were subjected to femtosecond-assisted myopic LASIK. Group A (n=4) served as a control group (no CXL). The corneas in LASIK+CXL group B were subjected to concurrent prophylactic high-irradiance CXL (n=4)...
June 2015: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/25751832/lasik-ablation-centration-an-objective-digitized-assessment-and-comparison-between-two-generations-of-an-excimer-laser
#18
COMPARATIVE STUDY
Anastasios John Kanellopoulos, George Asimellis
PURPOSE: To objectively define the effective centration of myopic femtosecond laser-assisted LASIK ablation pattern, evaluate the difference between achieved versus planned excimer laser ablation centration, and compare these results from two different generations of an excimer laser system. METHODS: The study retrospectively evaluated 280 eyes subjected to myopic LASIK. Digital image analysis was performed on Scheimpflug sagittal curvature maps (difference of preoperative to postoperative)...
March 2015: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/25709385/color-light-emitting-diode-reflection-topography-validation-of-keratometric-repeatability-in-a-large-sample-of-wide-cylindrical-range-corneas
#19
Anastasios John Kanellopoulos, George Asimellis
PURPOSE: To investigate repeatability of steep and flat keratometry measurements, as well as astigmatism axis in cohorts with normal range and regular astigmatic such as: eyes following laser-assisted in situ keratomileusis (LASIK) and normal population, as well as cohorts of high and irregular astigmatism such as keratoconic eyes, and keratoconic eyes following corneal collagen cross-linking, employing a novel corneal reflection topography device. METHODS: Steep and flat keratometry and astigmatism axis measurement repeatability was investigated employing a novel multicolored-spot reflection topographer (Cassini) in four study groups, namely a post myopic LASIK-treated Group A, a keratoconus Group B, a post-CXL keratoconus Group C, and a control Group D of routine healthy patients...
2015: Clinical Ophthalmology
https://www.readbyqxmd.com/read/25661135/digital-pupillometry-and-centroid-shift-changes-after-cataract-surgery
#20
COMPARATIVE STUDY
Anastasios John Kanellopoulos, George Asimellis, Stella Georgiadou
PURPOSE: To compare postoperative changes in apparent photopic and mesopic pupil size and centration in relation to cornea reflection landmarks after cataract surgery. SETTING: LaserVision.gr Clinical and Research Eye Institute, Athens, Greece. DESIGN: Prospective consecutive case study. METHODS: Pupils were imaged for pupil size and corneal vertex location before and 1-month after cataract surgery. Digital analysis of pupil images was used to determine the Cartesian coordinates (nasal-temporal, horizontal axis, superior-inferior, vertical axis) of the first Purkinje reflection point (approximating the corneal intersection of the visual axis [corneal vertex]) to the pupil geometric center (approximating the corneal intersection of the line of sight [corneal apex])...
February 2015: Journal of Cataract and Refractive Surgery
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