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JOURNAL ARTICLE
Andrea Corsini, Francesca Del Baldo, Francesco Lunetta, Serena Ribichini, Massimo Giunti, Francesca Fidanzio, Federico Fracassi
BACKGROUND: Acute illness can result in changes in serum total thyroxine (tT4), total triiodothyronine (tT3), and thyrotropin (TSH) concentrations in euthyroid dogs defined as nonthyroidal illness syndrome, but longitudinal evaluation of these hormones during the recovery phase is lacking. OBJECTIVES: To longitudinally evaluate serum tT4, tT3, and TSH concentrations during the acute phase and recovery from acute illness in dogs. ANIMALS: Nineteen euthyroid client-owned dogs hospitalized for acute illness at a veterinary teaching hospital...
April 23, 2024: Journal of Veterinary Internal Medicine
#2
Zeyuan Song, Sophia Gunn, Stefano Monti, Gina Marie Peloso, Ching-Ti Liu, Kathryn Lunetta, Paola Sebastiani
Gaussian Graphical Models (GGM) have been widely used in biomedical research to explore complex relationships between many variables. There are well established procedures to build GGMs from a sample of independent and identical distributed observations. However, many studies include clustered and longitudinal data that result in correlated observations and ignoring this correlation among observations can lead to inflated Type I error. In this paper, we propose a Bootstrap algorithm to infer GGM from correlated data...
April 5, 2024: bioRxiv
#3
JOURNAL ARTICLE
Jacopo Lanzone, Aida Zulueta, Marilisa Boscarino, Matteo Gallotta, Maria Rosaria Argentieri, Alessandro Viganò, Simone Sarasso, Michele A Colombo, Sasha D'Ambrosio, Christian Lunetta, Eugenio Parati
INTRODUCTION: Understanding the residual recovery potential in stroke patients is crucial for tailoring effective neurorehabilitation program s. We propose using EEG and plasmatic Neurofilament light chain (NfL) levels as a model to depict longitudinal patterns of stroke recovery. METHODS: We enrolled 13 patients (4 female, mean age 74.7 ± 8.8) who underwent stroke in the previous month and were hospitalized for 2-months rehabilitation. Patients underwent blood withdrawal, clinical evaluation and high-definition EEG at T1 (first week of rehabilitation) and at T2 (53 ± 10 days after)...
2024: Frontiers in Neurology
#4
JOURNAL ARTICLE
Veronica Facile, Maria Chiara Sabetti, Andrea Balboni, Lorenza Urbani, Alessandro Tirolo, Martina Magliocca, Francesco Lunetta, Francesco Dondi, Mara Battilani
Anaplasma phagocytophilum, Anaplasma platys and Ehrlichia canis, responsible of diseases in dogs, are tick-borne pathogens with a proven or potential zoonotic role that have shown increasing prevalence worldwide. The aims of this retrospective study were to assess the frequency of Anaplasma spp. and Ehrlichia spp. exposure in dogs tested in a veterinary teaching hospital in Italy over a 9-year period, to compare the performance of the diagnostic tests used, to evaluate correlations with clinical data, and to genetically analyse the identified bacteria...
March 27, 2024: Veterinary Research Communications
#5
JOURNAL ARTICLE
Rebecca Panitch, Nathan Sahelijo, Junming Hu, Kwangsik Nho, David A Bennett, Kathryn L Lunetta, Rhoda Au, Thor D Stein, Lindsay A Farrer, Gyungah R Jun
The joint effects of APOE genotype and DNA methylation on Alzheimer disease (AD) risk is relatively unknown. We conducted genome-wide methylation analyses using 2,021 samples in blood (91 AD cases, 329 mild cognitive impairment, 1,391 controls) and 697 samples in brain (417 AD cases, 280 controls). We identified differentially methylated levels in AD compared to controls in an APOE genotype-specific manner at 25 cytosine-phosphate-guanine (CpG) sites in brain and 36 CpG sites in blood. Additionally, we identified seven CpG sites in the APOE region containing TOMM40, APOE, and APOC1 genes with P < 5 × 10-8 between APOE ε4 carriers and non-carriers in brain or blood...
February 29, 2024: Translational Psychiatry
#6
JOURNAL ARTICLE
Daniele Spoladore, Vera Colombo, Vania Campanella, Christian Lunetta, Marta Mondellini, Atieh Mahroo, Federica Cerri, Marco Sacco
BACKGROUND: Dysphagia is a disorder that can be associated to several pathological conditions, including neuromuscular diseases, with significant impact on quality of life. Dysphagia often leads to malnutrition, as a consequence of the dietary changes made by patients or their caregivers, who may deliberately decide to reduce or avoid specific food consistencies (because they are not perceived as safe), and the lack of knowledge in how to process foods are critics. Such dietary changes often result in unbalanced nutrients intake, which can have significant consequences for frail patients...
February 19, 2024: Computers in Biology and Medicine
#7
JOURNAL ARTICLE
Laura Moreno-Martinez, Sofía Macías-Redondo, Mark Strunk, María Isabel Guillén-Antonini, Christian Lunetta, Claudia Tarlarini, Silvana Penco, Ana Cristina Calvo, Rosario Osta, Jon Schoorlemmer
Retroviral reverse transcriptase activity and the increased expression of human endogenous retroviruses (HERVs) are associated with amyotrophic lateral sclerosis (ALS). We were interested in confirming HERVK overexpression in the ALS brain, its use as an accessory diagnostic marker for ALS, and its potential interplay with neuroinflammation. Using qPCR to analyze HERVK expression in peripheral blood mononuclear cells (PBMCs) and in postmortem brain samples from ALS patients, no significant differences were observed between patients and control subjects...
January 26, 2024: International Journal of Molecular Sciences
#8
JOURNAL ARTICLE
Andrea Stoccoro, Adam R Smith, Lorena Mosca, Alessandro Marocchi, Francesca Gerardi, Christian Lunetta, Katie Lunnon, Lucia Migliore, Fabio Coppedè
Aim: To correlate mitochondrial D-loop region methylation levels and mtDNA copy number with disease duration in familial amyotrophic lateral sclerosis (ALS) patients. Patients & methods: The study population included 12 ALS patients with a mutation in SOD1 and 13 ALS patients with the C9orf72 hexanucleotide repeat expansion. Methylation levels of the D-loop region and mtDNA copy number were quantified using pyrosequencing and quantitative PCR, respectively. Results: We observed that D-loop methylation levels inversely correlated while mtDNA copy number positively correlated with disease duration...
February 5, 2024: Epigenomics
#9
JOURNAL ARTICLE
Heather M Ochs-Balcom, Leah Preus, Zhaohui Du, Robert C Elston, Craig C Teerlink, Guochong Jia, Xingyi Guo, Qiuyin Cai, Jirong Long, Jie Ping, Bingshan Li, Daniel O Stram, Xiao-Ou Shu, Maureen Sanderson, Guimin Gao, Thomas Ahearn, Kathryn L Lunetta, Gary Zirpoli, Melissa A Troester, Edward A Ruiz-Narváez, Stephen A Haddad, Jonine Figueroa, Esther M John, Leslie Bernstein, Jennifer J Hu, Regina G Ziegler, Sarah Nyante, Elisa V Bandera, Sue A Ingles, Nicholas Mancuso, Michael F Press, Sandra L Deming, Jorge L Rodriguez-Gil, Song Yao, Temidayo O Ogundiran, Oladosu Ojengbede, Manjeet K Bolla, Joe Dennis, Alison M Dunning, Douglas F Easton, Kyriaki Michailidou, Paul D P Pharoah, Dale P Sandler, Jack A Taylor, Qin Wang, Katie M O'Brien, Clarice R Weinberg, Cari M Kitahara, William Blot, Katherine L Nathanson, Anselm Hennis, Barbara Nemesure, Stefan Ambs, Lara E Sucheston-Campbell, Jeannette T Bensen, Stephen J Chanock, Andrew F Olshan, Christine B Ambrosone, Olufunmilayo I Olopade, David V Conti, Julie Palmer, Montserrat García-Closas, Dezheng Huo, Wei Zheng, Christopher Haiman
BACKGROUND: Expansion of genome-wide association studies across population groups is needed to improve our understanding of shared and unique genetic contributions to breast cancer. We performed association and replication studies guided by a priori linkage findings from African ancestry (AA) relative pairs. METHODS: We performed fixed-effect inverse-variance weighted meta-analysis under three significant AA breast cancer linkage peaks (3q26-27, 12q22-23, and 16q21-22) in 9241 AA cases and 10 193 AA controls...
January 23, 2024: Human Molecular Genetics
#10
Ahmed A Y Ragab, Margaret F Doyle, Jiachen Chen, Yuan Fang, Kathryn L Lunetta, Joanne M Murabito
Background The global increase in human life expectancy is evident. The total number of individuals aged 60 or above is anticipated to reach 2 billion by 2050. Aging, an inherently complex process, manifests prominently in the changes observed in the immune system. A notable marker of immune system aging is the presence of Aging-Related Immune Cell Phenotypes (ARIPs). Despite their significance, the connections between various ARIPs and mortality have not been thoroughly investigated. We prospectively investigated 16 different ARIPs using flow cytometry, namely, CD4/CD8 ratio, Granzyme B + CD8/Granyzme B + CD4, T N /T M = Tn / (Teff + Tem + Tcm) for T N /T M CD4 + and T N /T M CD8 + ratios, Th17/CD4 + Treg, Tc17/CD8 + Treg, Th17, Tc17, CD4 + Temra, CD8 + Temra, CD4 + CD25 + FoxP3+ (CD4 + Treg), CD8 + CD25 + FoxP3+ (CD8 + Treg) CD4 + CD27-, CD4 + CD28-CD27-, CD8 + CD27-, CD8 + CD28-CD27- and IL-6 in relation to survival outcome among dementia-free Framingham Heart Study (FHS) offspring cohort participants who attended the seventh exam (1998-2001)...
December 26, 2023: Research Square
#11
JOURNAL ARTICLE
Gary R Zirpoli, Ruth M Pfeiffer, Kimberly A Bertrand, Dezheng Huo, Kathryn L Lunetta, Julie R Palmer
BACKGROUND: Previous work in European ancestry populations has shown that adding a polygenic risk score (PRS) to breast cancer risk prediction models based on epidemiologic factors results in better discriminatory performance as measured by the AUC (area under the curve). Following publication of the first PRS to perform well in women of African ancestry (AA-PRS), we conducted an external validation of the AA-PRS and then evaluated the addition of the AA-PRS to a risk calculator for incident breast cancer in Black women based on epidemiologic factors (BWHS model)...
January 2, 2024: Breast Cancer Research: BCR
#12
JOURNAL ARTICLE
Gemma Donato, Alessia Lunetta, Andrea Spinelli, Gaetano Catanese, Salvatore Giacobbe
The rapid spread of the protozoan Haplosporidium pinnae is having a strong negative effect on Pinna nobilis populations. A case study on a residual population in Lake Faro (Sicily, Central Mediterranean), whose long-term monitoring has revealed a dramatic decline following the 2018-2020 mass mortality event, is presented. In the framework of such monitoring, we performed tissue sampling on 9 living P. nobilis, detecting the pathogen in 7 of them. In contrast, other pathogens associated with P. nobilis disease in other areas, i...
October 31, 2023: Journal of Invertebrate Pathology
#13
REVIEW
Davide Sattin, Chiara Parma, Christian Lunetta, Aida Zulueta, Jacopo Lanzone, Luca Giani, Marta Vassallo, Mario Picozzi, Eugenio Agostino Parati
Given the widespread debate on the definition of the terms "Body Schema" and "Body Image", this article presents a broad overview of the studies that have investigated the nature of these types of body representations, especially focusing on the innovative information about these two representations that could be useful for the rehabilitation of patients with different neurological disorders with motor deficits (especially those affecting the upper limbs). In particular, we analyzed (i) the different definitions and explicative models proposed, (ii) the empirical settings used to test them and (iii) the clinical and rehabilitative implications derived from the application of interventions on specific case reports...
October 4, 2023: Brain Sciences
#14
JOURNAL ARTICLE
Qiushan Tao, Chao Zhang, Gustavo Mercier, Kathryn Lunetta, Ting Fang Alvin Ang, Samia Akhter-Khan, Zhengrong Zhang, Andrew Taylor, Ronald J Killiany, Michael Alosco, Jesse Mez, Rhoda Au, Xiaoling Zhang, Lindsay A Farrer, Wendy Wei Qiao Qiu
INTRODUCTION: The precise apolipoprotein E ( APOE ) ε4-specific molecular pathway(s) for Alzheimer's disease (AD) risk are unclear. METHODS: Plasma protein modules/cascades were analyzed using weighted gene co-expression network analysis (WGCNA) in the Alzheimer's Disease Neuroimaging Initiative study. Multivariable regression analyses were used to examine the associations among protein modules, AD diagnoses, cerebrospinal fluid (CSF) phosphorylated tau (p-tau), and brain glucose metabolism, stratified by APOE genotype...
2023: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
#15
Jinghan Huang, Yixuan Wang, Thor D Stein, Ting Fang Alvin Ang, Yibo Zhu, Qiushan Tao, Kathryn L Lunetta, Jesse Mez, Rhoda Au, Lindsay A Farrer, Wei Qiao Qiu, Xiaoling Zhang
BACKGROUND: Previous study shows that monocyte chemoattractant protein-1 (MCP-1), which is implicated in the peripheral proinflammatory cascade and blood-brain barrier (BBB) disruption, modulates the genetic risks of AD in established AD loci. METHODS: In this study, we hypothesized that blood MCP-1 impacts the AD risk of genetic variants beyond known AD loci. We thus performed a genome-wide association study (GWAS) using the logistic regression via generalized estimating equations (GEE) and the Cox proportional-hazards models to examine the interactive effects between single nucleotide polymorphisms (SNPs) and blood MCP-1 level on AD in three cohorts: the Framingham Heart Study (FHS), Alzheimer's Disease Neuroimaging Initiative (ADNI) and Religious Orders Study/Memory and Aging Project (ROSMAP)...
September 28, 2023: Research Square
#16
REVIEW
Gary L Pattee, Angela Genge, Philippe Couratier, Christian Lunetta, Gen Sobue, Masashi Aoki, Hiide Yoshino, Carlayne E Jackson, James Wymer, Alejandro Salah, Sally Nelson
INTRODUCTION: Amyotrophic lateral sclerosis (ALS) is a progressive and incurable neurodegenerative disease. While pharmacotherapy options remain limited, the Food and Drug Administration (FDA) approved intravenous (IV) and oral edaravone for the treatment of ALS in 2017 and 2022, respectively. With the addition of oral edaravone, patients with ALS may exclusively use oral medications. AREAS COVERED: The authors performed a review of the published literature using the United States (US) National Library of Medicine's PubMed...
September 12, 2023: Expert Review of Neurotherapeutics
#17
JOURNAL ARTICLE
Jessica Mandrioli, Roberto D'Amico, Elisabetta Zucchi, Sara De Biasi, Federico Banchelli, Ilaria Martinelli, Cecilia Simonini, Domenico Lo Tartaro, Roberto Vicini, Nicola Fini, Giulia Gianferrari, Marcello Pinti, Christian Lunetta, Francesca Gerardi, Claudia Tarlarini, Letizia Mazzini, Fabiola De Marchi, Ada Scognamiglio, Gianni Sorarù, Andrea Fortuna, Giuseppe Lauria, Eleonora Dalla Bella, Claudia Caponnetto, Giuseppe Meo, Adriano Chio, Andrea Calvo, Andrea Cossarizza
In preclinical studies rapamycin was found to target neuroinflammation, by expanding regulatory T cells, and affecting autophagy, two pillars of amyotrophic lateral sclerosis (ALS) pathogenesis. Herein we report a multicenter, randomized, double-blind trial, in 63 ALS patients who were randomly assigned in a 1:1:1 ratio to receive rapamycin 2 mg/m2 /day,1 mg/m2 /day or placebo (EUDRACT 2016-002399-28; NCT03359538). The primary outcome, the number of patients exhibiting an increase >30% in regulatory T cells from baseline to treatment end, was not attained...
August 17, 2023: Nature Communications
#18
JOURNAL ARTICLE
Jiachen Chen, Margaret F Doyle, Yuan Fang, Jesse Mez, Paul K Crane, Phoebe Scollard, Claudia L Satizabal, Michael L Alosco, Wei Qiao Qiu, Joanne M Murabito, Kathryn L Lunetta
Inflammatory protein biomarkers induced by immune responses have been associated with cognitive decline and the pathogenesis of Alzheimer's disease (AD). Here, we investigate associations between a panel of inflammatory biomarkers and cognitive function and incident dementia outcomes in the well-characterized Framingham Heart Study Offspring cohort. Participants aged ≥40 years and dementia-free at Exam 7 who had a stored plasma sample were selected for profiling using the OLINK proteomics inflammation panel...
August 16, 2023: Aging Cell
#19
JOURNAL ARTICLE
Yuan Fang, Margaret F Doyle, Jiachen Chen, Jesse Mez, Claudia L Satizabal, Michael L Alosco, Wei Qiao Qiu, Kathryn L Lunetta, Joanne M Murabito
No abstract text is available yet for this article.
August 14, 2023: Aging
#20
JOURNAL ARTICLE
Marlene Tejeda, John Farrell, Congcong Zhu, Lee Wetzler, Kathryn L Lunetta, William S Bush, Eden R Martin, Li-San Wang, Gerard D Schellenberg, Margaret A Pericak-Vance, Jonathan L Haines, Lindsay A Farrer, Richard Sherva
INTRODUCTION: Multiple infectious agents, including viruses, bacteria, fungi, and protozoa, have been linked to Alzheimer's disease (AD) risk by independent lines of evidence. We explored this association by comparing the frequencies of viral species identified in a large sample of AD cases and controls. METHODS: DNA sequence reads that did not align to the human genome in sequences were mapped to viral reference sequences, quantified, and then were tested for association with AD in whole exome sequences (WES) and whole genome sequences (WGS) datasets...
August 14, 2023: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
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