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Mark Terry ocular

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https://www.readbyqxmd.com/read/26851486/glycan-involvement-in-the-adhesion-of-pseudomonas-aeruginosa-to-tears
#1
Liisa Kautto, Terry Nguyen-Khuong, Arun Everest-Dass, Andrea Leong, Zhenjun Zhao, Mark D P Willcox, Nicolle H Packer, Robyn Peterson
The human eye is constantly bathed by tears, which protect the ocular surface via a variety of mechanisms. The O-linked glycans of tear mucins have long been considered to play a role in binding to pathogens and facilitating their removal in the tear flow. Other conjugated glycans in tears could similarly contribute to pathogen binding and removal but have received less attention. In the work presented here we assessed the contribution of glycan moieties, in particular the protein attached N-glycans, presented by the broad complement of tear proteins to the adhesion of the opportunistic pathogen Pseudomonas aeruginosa, a leading cause of microbial keratitis and ulceration of the cornea...
April 2016: Experimental Eye Research
https://www.readbyqxmd.com/read/26271841/the-first-100-eyes-of-standardized-descemet-stripping-automated-endothelial-keratoplasty-versus-standardized-descemet-membrane-endothelial-keratoplasty
#2
COMPARATIVE STUDY
Ebru C Hamzaoglu, Michael D Straiko, Zachary M Mayko, Christopher S Sáles, Mark A Terry
PURPOSE: To compare results of the first 100 eyes of Descemet stripping automated endothelial keratoplasty (DSAEK) and Descemet membrane endothelial keratoplasty (DMEK) that were performed with a standardized technique at a single institution. DESIGN: Single-center, retrospective case series. PARTICIPANTS: The first 100 eyes of standardized DSAEK and DMEK that underwent surgery for Fuchs corneal dystrophy at our center. We excluded patients with prior ocular surgery other than cataract surgery to limit confounding variables...
November 2015: Ophthalmology
https://www.readbyqxmd.com/read/25303961/glycomic-characterization-of-basal-tears-and-changes-with-diabetes-and-diabetic-retinopathy
#3
Terry Nguyen-Khuong, Arun V Everest-Dass, Liisa Kautto, Zhenjun Zhao, Mark D P Willcox, Nicolle H Packer
As a secreted fluid, the state of tear glycosylation is particularly important in the role of immunity of the ocular surface. Tears are a valuable source of non-invasive biomarkers for disease and there are continued efforts to characterize their components thoroughly. In this study, a small volume of basal tears (5 μL) was collected from healthy controls, patients with diabetes without retinopathy and patients with diabetes and retinopathy. The detailed N- and O-linked tear protein glycome was characterized and the relative abundance of each structure determined...
March 2015: Glycobiology
https://www.readbyqxmd.com/read/24084322/inadvertent-placement-of-a-glaucoma-tube-into-the-graft-host-interface-of-an-eye-with-previous-descemet-stripping-automated-endothelial-keratoplasty
#4
Jeffrey M Goshe, Mark A Terry, Jennifer Y Li
PURPOSE: The aim of this study was to report the inadvertent insertion of a glaucoma tube into the graft-host interface in a patient with previous Descemet stripping automated endothelial keratoplasty (DSAEK). METHODS: This is a retrospective case report. RESULTS: A 56-year-old aniridic woman with a history of multiple failed penetrating keratoplasties (PKPs) and glaucoma underwent DSAEK under failed PKP of her left eye at our institution...
October 2013: Journal of Glaucoma
https://www.readbyqxmd.com/read/22685421/genetic-variants-on-chromosome-1q41-influence-ocular-axial-length-and-high-myopia
#5
Qiao Fan, Veluchamy A Barathi, Ching-Yu Cheng, Xin Zhou, Akira Meguro, Isao Nakata, Chiea-Chuen Khor, Liang-Kee Goh, Yi-Ju Li, Wan'e Lim, Candice E H Ho, Felicia Hawthorne, Yingfeng Zheng, Daniel Chua, Hidetoshi Inoko, Kenji Yamashiro, Kyoko Ohno-Matsui, Keitaro Matsuo, Fumihiko Matsuda, Eranga Vithana, Mark Seielstad, Nobuhisa Mizuki, Roger W Beuerman, E-Shyong Tai, Nagahisa Yoshimura, Tin Aung, Terri L Young, Tien-Yin Wong, Yik-Ying Teo, Seang-Mei Saw
As one of the leading causes of visual impairment and blindness, myopia poses a significant public health burden in Asia. The primary determinant of myopia is an elongated ocular axial length (AL). Here we report a meta-analysis of three genome-wide association studies on AL conducted in 1,860 Chinese adults, 929 Chinese children, and 2,155 Malay adults. We identified a genetic locus on chromosome 1q41 harboring the zinc-finger 11B pseudogene ZC3H11B showing genome-wide significant association with AL variation (rs4373767, β = -0...
2012: PLoS Genetics
https://www.readbyqxmd.com/read/22385970/graft-dislocation-and-hypotony-after-descemet-s-stripping-automated-endothelial-keratoplasty-in-patients-with-previous-glaucoma-surgery
#6
COMPARATIVE STUDY
Jeffrey M Goshe, Mark A Terry, Jennifer Y Li, Michael D Straiko, David Davis-Boozer
PURPOSE: To determine if patients with prior glaucoma surgery experience higher rates of postoperative graft dislocation after Descemet's stripping automated endothelial keratoplasty (DSAEK) and to determine if postoperative hypotony may be a risk factor in these patients. DESIGN: Retrospective, comparative analysis of an interventional case series. PARTICIPANTS: Eight hundred fifty-four eyes (67 eyes with prior glaucoma surgery and 787 controls) from 582 patients who underwent DSAEK at 1 institution between January 2005 and April 2011...
June 2012: Ophthalmology
https://www.readbyqxmd.com/read/22364863/three-year-visual-acuity-outcomes-after-descemet-s-stripping-automated-endothelial-keratoplasty
#7
Jennifer Y Li, Mark A Terry, Jeffrey Goshe, David Davis-Boozer, Neda Shamie
PURPOSE: To evaluate the long-term improvement of visual acuity after Descemet's stripping automated endothelial keratoplasty (DSAEK) surgery. DESIGN: Retrospective analysis of a noncomparative, interventional case series. PARTICIPANTS: One hundred eight patients undergoing DSAEK surgery for Fuchs' endothelial dystrophy and pseudophakic bullous keratopathy without other ocular comorbidities who completed a full 3-year follow-up period. METHODS: Postoperative best spectacle-corrected visual acuity (BSCVA) was recorded at 6, 12, 24, and 36 months...
June 2012: Ophthalmology
https://www.readbyqxmd.com/read/21169529/3-d-characterization-of-the-corneal-shape-in-fuchs-dystrophy-and-pseudophakic-keratopathy
#8
MULTICENTER STUDY
Isabelle Brunette, Denis Sherknies, Mark A Terry, Miguel Chagnon, Jean-Louis Bourges, Jean Meunier
PURPOSE: To characterize the 3-D corneal shape deformation incurred by Fuchs corneal dystrophy and pseudophakic bullous keratopathy by using the integrated analysis of Orbscan (Bausch & Lomb Surgical, Rochester, NY) topographic maps of affected and normal corneas. METHODS: One hundred thirty-seven patients with Fuchs dystrophy or pseudophakic keratopathy were divided into three groups according to the severity of the disease: mild (central corneal thickness [CCT], 500-710 μm; n = 46); moderate (710-775 μm; n = 45), and severe (775-1100 μm; n = 46)...
January 2011: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/20172066/complications-and-clinical-outcomes-of-descemet-stripping-automated-endothelial-keratoplasty-with-intraocular-lens-exchange
#9
Anand K Shah, Mark A Terry, Neda Shamie, Edwin S Chen, Paul M Phillips, Karen L Hoar, Daniel J Friend, David Davis-Boozer
PURPOSE: To evaluate complications and clinical outcomes of Descemet stripping automated endothelial keratoplasty (DSAEK) with intraocular lens (IOL) exchange compared with DSAEK alone. DESIGN: Retrospective, interventional case series. METHODS: DSAEK was performed in 19 eyes in which the anterior chamber IOL was exchanged for a posterior chamber IOL (study group) and in 188 eyes in which the posterior chamber IOL was left in place (comparison group)...
March 2010: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/20111972/analysis-of-posterior-donor-corneal-parameters-1-year-after-descemet-stripping-automated-endothelial-keratoplasty-dsaek-triple-procedure
#10
Marco Lombardo, Mark A Terry, Giuseppe Lombardo, David D Boozer, Sebastiano Serrao, Pietro Ducoli
BACKGROUND: Although Descemet stripping automated endothelial keratoplasty (DSAEK) was demonstrated to be effective for the treatment of endothelial corneal diseases, a variable hyperopic shift has been measured as a common occurrence postoperatively. The aim of this work was to investigate the variance in the corneal and refractive responses to DSAEK combined with phacoemulsification and implantation of intra-ocular lens (IOL), namely the DSAEK triple procedure. METHODS: The refractive, topographic, and anterior segment optical coherence tomography (AS-OCT) data of 23 eyes treated with DSAEK triple procedure were analyzed...
March 2010: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/20100096/the-role-of-vision-in-academic-school-performance
#11
Mohamed Dirani, Xiaoe Zhang, Liang Ke Goh, Terri L Young, Paul Lee, Seang Mei Saw
PURPOSE: To determine whether presenting distance visual acuity is related to subsequent academic school performance in Singaporean children between 9 to 10 years of age. METHODS: Singapore children (n = 1143 children) were examined during their visits at ages 9 to 10 years (grades 3 to 4) as part of the Singapore Cohort Study of the Risk Factors for Myopia (SCORM) longitudinal study. Each child underwent an annual comprehensive eye examination, including the assessment of presenting logarithm of the minimum angle of resolution (LogMAR) distance visual acuity (VA)...
January 2010: Ophthalmic Epidemiology
https://www.readbyqxmd.com/read/19411959/long-term-anterior-and-posterior-topographic-analysis-of-the-cornea-after-deep-lamellar-endothelial-keratoplasty
#12
Marco Lombardo, Giuseppe Lombardo, Daniel J Friend, Sebastiano Serrao, Mark A Terry
PURPOSE: To analyze the 2-year topographic response of the cornea to deep lamellar endothelial keratoplasty (DLEK). METHODS: The Orbscan topographies of 24 eyes that underwent DLEK for corneal decompensation were retrospectively analyzed. Twelve eyes received a large-incision DLEK technique and 12 eyes received a small-incision DLEK. All the preoperative and postoperative corneal raw data were imported into a custom software program, which computed the average composite corneal maps and difference maps for both study groups to evaluate the corneal response to the surgery...
May 2009: Cornea
https://www.readbyqxmd.com/read/19091414/precut-tissue-for-descemet-s-stripping-automated-endothelial-keratoplasty-vision-astigmatism-and-endothelial-survival
#13
Mark A Terry, Neda Shamie, Edwin S Chen, Paul M Phillips, Karen L Hoar, Daniel J Friend
PURPOSE: To report 6 and 12 month results using precut tissue for Descemet's stripping automated endothelial keratoplasty (DSAEK) and correlate donor characteristics with clinical outcomes. DESIGN: Prospective, noncomparative, interventional case series. PARTICIPANTS: We reviewed 100 donor corneas precut for 100 eyes of 90 DSAEK patients. METHODS: Our first 100 consecutive cases of DSAEK with precut tissue were entered into a prospective protocol...
February 2009: Ophthalmology
https://www.readbyqxmd.com/read/18520497/descemet-stripping-automated-endothelial-keratoplasty-six-month-results-in-a-prospective-study-of-100-eyes
#14
Edwin S Chen, Mark A Terry, Neda Shamie, Karen L Hoar, Daniel J Friend
PURPOSE: To report 6-month results in a large, prospective study of Descemet-stripping automated endothelial keratoplasty (DSAEK). METHODS: A 5-mm scleral-limbal tunnel approach was created for placement of an automated microkeratome-prepared 8.0-mm endothelial graft after DSAEK in 150 consecutive cases between September 2005 and October 2006. Six-month follow-up data were available on 100 eyes. Intraoperative peripheral scraping was performed to promote adherence of the donor...
June 2008: Cornea
https://www.readbyqxmd.com/read/17883910/efficacy-of-olopatadine-ophthalmic-solution-0-2-in-reducing-signs-and-symptoms-of-allergic-conjunctivitis
#15
RANDOMIZED CONTROLLED TRIAL
Mark B Abelson, Paul J Gomes, Terri Pasquine, Michael R Edwards, Robert D Gross, Stella M Robertson
Olopatadine hydrochloride ophthalmic solution 0.2% (Pataday, Alcon) is a new formulation of olopatadine hydrochloride ophthalmic solution, the first topical ocular antiallergic agent indicated for once-daily dosing. The aim of this study was to evaluate the safety, efficacy, onset, and duration of action of olopatadine 0.2% in the treatment of allergic conjunctivitis. Using the conjunctival allergen challenge, this double-masked, randomized by eye, parallel-group study included four visits over a 5-week period...
July 2007: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/15969867/effects-of-a-new-formulation-of-olopatadine-ophthalmic-solution-on-nasal-symptoms-relative-to-placebo-in-two-studies-involving-subjects-with-allergic-conjunctivitis-or-rhinoconjunctivitis
#16
RANDOMIZED CONTROLLED TRIAL
Mark B Abelson, Paul J Gomes, Cullen T Vogelson, Terri A Pasquine, F Darell Turner, David T Wells, Stella M Robertson
BACKGROUND: A new formulation of olopatadine hydrochloride ophthalmic solution (olopatadine 0.2%) was evaluated in two separate, randomized, placebo-controlled, double-masked, hybrid environmental studies intended to determine efficacy and safety in subjects with histories of seasonal allergic conjunctivitis or rhinoconjunctivitis. DESIGN AND METHODS: In these 10- and 12-week trials (conducted April-August 2003 and July-December 2001, respectively), subjects assessed their ocular signs and symptoms...
May 2005: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/15541079/pregnancy-and-obstetrical-outcomes-in-pseudoxanthoma-elasticum
#17
L Bercovitch, T Leroux, S Terry, M A Weinstock
BACKGROUND: Pseudoxanthoma elasticum (PXE) is a genetic multisystem disorder characterized by calcified dystrophic elastic fibres in skin, retina and arteries. Much of the earlier literature on pregnancy in PXE contained reports of severe complications, leading some healthcare providers to advise women with PXE against becoming pregnant and some women with PXE to avoid pregnancy. OBJECTIVES: To evaluate the obstetrical outcomes and the incidence of pregnancy complications in women with PXE and to determine if pregnancy is associated with an adverse effect on the course of the disease...
November 2004: British Journal of Dermatology
https://www.readbyqxmd.com/read/15476905/clinical-efficacy-of-olopatadine-hydrochloride-ophthalmic-solution-0-2-compared-with-placebo-in-patients-with-allergic-conjunctivitis-or-rhinoconjunctivitis-a-randomized-double-masked-environmental-study
#18
RANDOMIZED CONTROLLED TRIAL
Mark B Abelson, Paul J Gomes, Cullen T Vogelson, Terri A Pasquine, Robert D Gross, F Darell Turner, David T Wells, Michael V W Bergamini, Stella M Robertson
BACKGROUND: Previous studies have suggested that olopatadine hydrochloride ophthalmic solution 0.2% administered once daily is effective for up to 24 hours after instillation and is well tolerated in adults and children aged > or =3 years. OBJECTIVE: The goal of this study was to evaluate the efficacy and safety profile of olopatadine 0.2% compared with placebo in patients with seasonal allergic conjunctivitis or rhinoconjunctivitis. METHODS: This was a 10-week, randomized, placebo-controlled, double-masked environmental study conducted during the spring allergy season (April-August) of 2003...
August 2004: Clinical Therapeutics
https://www.readbyqxmd.com/read/15055565/preclinical-and-clinical-antiallergic-effect-of-olopatadine-0-2-solution-24-hours-after-topical-ocular-administration
#19
RANDOMIZED CONTROLLED TRIAL
Cullen T Vogelson, Mark B Abelson, Terri Pasquine, Donna M Stephens, Daniel A Gamache, Robert D Gross, Stella M Robertson, John M Yanni
Pharmacologic studies examined the potential of a solution containing olopatadine to maintain and extend antiallergic efficacy after single topical ocular drop administration over 24 hours. Results of these preclinical experiments conducted in guinea pigs indicated that olopatadine 0.2% (wt/vol) solution was significantly effective 24 hours after dosing. This concentration of olopatadine provided significantly more efficacy than Patanol (olopatadine 0.1%) 24 hours after administration while being as effective as Patanol (olopatadine 0...
January 2004: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/14508258/in-pursuit-of-emmetropia-spherical-equivalent-refraction-results-with-deep-lamellar-endothelial-keratoplasty-dlek
#20
Mark A Terry, Paula J Ousley
PURPOSE: To determine if the new technique for endothelial transplantation of DLEK (deep lamellar endothelial keratoplasty) can offer predictable corneal curvature and improved refractive spherical equivalent results compared with reports for traditional penetrating keratoplasty. METHODS: Twenty-seven consecutive Fuchs corneal dystrophy patients received DLEK surgery to replace their endothelium. Topographic corneal curvature and refractive spherical equivalents were evaluated at preop and at 6 and 12 months postop...
October 2003: Cornea
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