Jonathan H Lass, Alan Sugar, Beth Ann Benetz, Roy W Beck, Mariya Dontchev, Robin L Gal, Craig Kollman, Robert Gross, Ellen Heck, Edward J Holland, Mark J Mannis, Irving Raber, Walter Stark, R Doyle Stulting
OBJECTIVE: To determine whether preoperative and/or postoperative central endothelial cell density (ECD) and its rate of decline postoperatively are predictive of graft failure caused by endothelial decompensation following penetrating keratoplasty to treat a moderate-risk condition, principally, Fuchs dystrophy or pseudophakic corneal edema. METHODS: In a subset of Cornea Donor Study participants, a central reading center determined preoperative and postoperative ECD from available specular images for 17 grafts that failed because of endothelial decompensation and 483 grafts that did not fail...
January 2010: Archives of Ophthalmology