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Arivudainambi Kayal, Viswanathan Mohan, Belma Malanda, Ranjit Mohan Anjana, Balaji Bhavadharini, Manni Mohanraj Mahalakshmi, Kumar Maheswari, Ram Uma, Ranjit Unnikrishnan, Gunasekaran Kalaiyarasi, Lyudmil Ninov, Anne Belton
AIM: The Women In India with GDM Strategy (WINGS) project was conducted with the aim of developing a model of care (MOC) suitable for women with gestational diabetes mellitus (GDM) in low- and middle-income countries. METHODOLOGY: The WINGS project was carried out in Chennai, Southern India, in two phases. In Phase I, a situational analysis was conducted to understand the practice patterns of health-care professionals and to determine the best screening criteria through a pilot screening study...
September 2016: Indian Journal of Endocrinology and Metabolism
J Tan, L Almeida, A Bewley, B Cribier, N Dlova, R Gallo, G Kautz, M Mannis, H Oon, M Rajagopalan, M Steinhoff, D Thiboutot, P Troielli, G Webster, Y Wu, E van Zuuren, M Schaller
BACKGROUND: Rosacea is currently diagnosed by consensus-defined primary and secondary features and managed by subtype. However, individual features (phenotypes) can span multiple subtypes, which has implications for clinical practice and research. Adopting a phenotype-led approach may facilitate patient-centred management. OBJECTIVES: To advance clinical practice by obtaining international consensus to establish a phenotype-led rosacea diagnosis and classification scheme with global representation...
October 8, 2016: British Journal of Dermatology
Gaia Gozzi, Sonia T Chelbi, Paola Manni, Loredana Alberti, Sergio Fonda, Sara Saponaro, Luca Fabbiani, Francesco Rivasi, Jean Benhattar, Lorena Losi
TBX15 is a gene involved in the development of mesodermal derivatives. As the ovaries and the female reproductive system are of mesodermal origin, the aim of the present study was to determine the methylation status of the TBX15 gene promoter and the expression levels of TBX15 in ovarian carcinoma, which is the most lethal and aggressive type of gynecological tumor, in order to determine the role of TBX15 in the pathogenesis of ovarian carcinoma. This alteration could be used to predict tumor development, progression, recurrence and therapeutic effects...
October 2016: Oncology Letters
Wenqian He, Gene S Tan, Caitlin E Mullarkey, Amanda J Lee, Mannie Man Wai Lam, Florian Krammer, Carole Henry, Patrick C Wilson, Ali A Ashkar, Peter Palese, Matthew S Miller
The generation of strain-specific neutralizing antibodies against influenza A virus is known to confer potent protection against homologous infections. The majority of these antibodies bind to the hemagglutinin (HA) head domain and function by blocking the receptor binding site, preventing infection of host cells. Recently, elicitation of broadly neutralizing antibodies which target the conserved HA stalk domain has become a promising "universal" influenza virus vaccine strategy. The ability of these antibodies to elicit Fc-dependent effector functions has emerged as an important mechanism through which protection is achieved in vivo...
October 3, 2016: Proceedings of the National Academy of Sciences of the United States of America
Mannie Man Wai Lam, Jonathan P Mapletoft, Matthew S Miller
Alzheimer's disease, Parkinson's disease, multiple sclerosis, and amyotrophic lateral sclerosis are a few examples of debilitating neurological/neurodegenerative diseases for which there are currently no curative treatments. Recent evidence has strongly suggested a role for neuroinflammation in both the onset and progression of these diseases. However, the mechanisms that initiate neuroinflammation are presently unclear. Mounting evidence suggests that environmental factors are likely involved. One proposed mechanism linking both genetic and environmental factors is dysregulation of the antiviral response...
December 2016: Cytokine
Yifan Li, Jing Zeng, Manni Huang, Jusheng An, Ping Bai, Lingying Wu, Rong Zhang
BACKGROUND: Nanoparticle albumin-bound paclitaxel (nab-paclitaxel) and nedaplatin (NDP) are used for the treatment of patients with cervical cancer. However, to the authors' knowledge, the use of this combination regimen among patients with advanced, recurrent, or metastatic cervical cancer has rarely been reported. METHODS: Patients with pathologically confirmed, stage IVB (FIGO staging 2009), recurrent or metastatic cervical cancer were eligible. Nab-paclitaxel at a dose of 175 mg/m(2) plus NDP at a dose of 80 mg/m(2) was administered intravenously every 3 weeks...
October 3, 2016: Cancer
Manish Kumar Rana, Manni Luthra-Guptasarma
The MHC Class I molecule, HLA-B27, is strongly linked with development of the inflammatory arthritic disease, ankylosing spondylitis (AS); whereas the B*2705 subtype shows strong association, B*2709 is not associated with disease, even though the two subtypes differ in only a single residue at position 116. Currently, attention is focused on the misfolding propensities of these two subtypes, including studies of disulfide-linked dimers and non-covalently formed high molecular weight (HMW) aggregates. Using mutants retaining only a single cysteine at positions C67 or C164, and using a cysteine-reactive, environment-sensitive, fluorescence probe (acrylodan), we find that within the same overall population of identical single-cysteine HLA-B27 molecules, there exist sub-populations which (a) possess free cysteines which react with acrylodan, (b) form disulfide-linked dimers, and (c) form HMW aggregates...
September 28, 2016: International Journal of Biological Macromolecules
Donny W Suh, Marjean T Kulp, Trevano W Dean, David K Wallace, Raymond T Kraker, Ruth E Manny, Sergul A Erzurum, Yi Pang, Caroline J Shea, John M Avallone
No abstract text is available yet for this article.
September 20, 2016: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
Alexie Papanicolaou, Marc F Schetelig, Peter Arensburger, Peter W Atkinson, Joshua B Benoit, Kostas Bourtzis, Pedro Castañera, John P Cavanaugh, Hsu Chao, Christopher Childers, Ingrid Curril, Huyen Dinh, HarshaVardhan Doddapaneni, Amanda Dolan, Shannon Dugan, Markus Friedrich, Giuliano Gasperi, Scott Geib, Georgios Georgakilas, Richard A Gibbs, Sarah D Giers, Ludvik M Gomulski, Miguel González-Guzmán, Ana Guillem-Amat, Yi Han, Artemis G Hatzigeorgiou, Pedro Hernández-Crespo, Daniel S T Hughes, Jeffery W Jones, Dimitra Karagkouni, Panagiota Koskinioti, Sandra L Lee, Anna R Malacrida, Mosè Manni, Kostas Mathiopoulos, Angela Meccariello, Shwetha C Murali, Terence D Murphy, Donna M Muzny, Georg Oberhofer, Félix Ortego, Maria D Paraskevopoulou, Monica Poelchau, Jiaxin Qu, Martin Reczko, Hugh M Robertson, Andrew J Rosendale, Andrew E Rosselot, Giuseppe Saccone, Marco Salvemini, Grazia Savini, Patrick Schreiner, Francesca Scolari, Paolo Siciliano, Sheina B Sim, George Tsiamis, Enric Ureña, Ioannis S Vlachos, John H Werren, Ernst A Wimmer, Kim C Worley, Antigone Zacharopoulou, Stephen Richards, Alfred M Handler
BACKGROUND: The Mediterranean fruit fly (medfly), Ceratitis capitata, is a major destructive insect pest due to its broad host range, which includes hundreds of fruits and vegetables. It exhibits a unique ability to invade and adapt to ecological niches throughout tropical and subtropical regions of the world, though medfly infestations have been prevented and controlled by the sterile insect technique (SIT) as part of integrated pest management programs (IPMs). The genetic analysis and manipulation of medfly has been subject to intensive study in an effort to improve SIT efficacy and other aspects of IPM control...
2016: Genome Biology
Antonio Manni, Marco Pasini, Maria Rita Giuca, Riccardo Morganti, Mauro Cozzani
BACKGROUND: The aim of this study is to investigate the pharyngeal airway space changes in patients treated with rapid palatal expansion (RPE) and Herbst appliance with or without skeletal anchorage. METHODS: A 40-patient study group treated with the Herbst RME combination was included; moreover, a comparison between two subgroups based on whether miniscrews were used was evaluated. A subgroup 1 included 20 patients who were treated with RPE and an acrylic splint Herbst with miniscrews, and subgroup 2 included 20 patients who were treated with RPE and an acrylic splint Herbst...
December 2016: Progress in Orthodontics
Elisa Principi, Rossana Girardello, Antonino Bruno, Isabella Manni, Elisabetta Gini, Arianna Pagani, Annalisa Grimaldi, Federico Ivaldi, Terenzio Congiu, Daniela De Stefano, Giulia Piaggio, Magda de Eguileor, Douglas M Noonan, Adriana Albini
The increasing use of carbon nanotubes (CNTs) in several industrial applications raises concerns on their potential toxicity due to factors such as tissue penetrance, small dimensions, and biopersistence. Using an in vivo model for CNT environmental exposure, mimicking CNT exposition at the workplace, we previously found that CNTs rapidly enter and disseminate in the organism, initially accumulating in the lungs and brain and later reaching the liver and kidneys via the bloodstream in CD1 mice. Here, we monitored and traced the accumulation of single-walled CNTs (SWCNTs), administered systemically in mice, in different organs and the subsequent biological responses...
2016: International Journal of Nanomedicine
Duncheng Wang, Debjani Ghosh, S M Touhidul Islam, Cody D Moorman, Ashton E Thomason, Daniel S Wilkinson, Mark D Mannie
This study introduces a flexible format for tolerogenic vaccination that incorporates IFN-β and neuroantigen (NAg) in the Alum adjuvant. Tolerogenic vaccination required all three components, IFN-β, NAg, and Alum, for inhibition of experimental autoimmune encephalomyelitis (EAE) and induction of tolerance. Vaccination with IFN-β + NAg in Alum ameliorated NAg-specific sensitization and inhibited EAE in C57BL/6 mice in pretreatment and therapeutic regimens. Tolerance induction was specific for the tolerogenic vaccine Ag PLP178-191 or myelin oligodendrocyte glycoprotein (MOG)35-55 in proteolipid protein- and MOG-induced models of EAE, respectively, and was abrogated by pretreatment with a depleting anti-CD25 mAb...
September 12, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
Manish Kumar Rana, Manni Luthra-Guptasarma
A self-derived-peptide with the same amino acid sequence (N-RRYLENGKETLQR-C) as residues 169-181 of the human leukocyte antigen (HLA) B27 heavy chain is known to bind to MHC Class I complexes containing the HLA-B27 heavy chain. This observation has been invoked previously in at least two different (but related) molecular explanations for the disease-association of the HLA-B27 allele. Here, we use a combination of fluorescence polarization, competitive inhibition and gel filtration chromatographic studies to show that a fluorescently-labeled peptide of the above sequence binds to two disease-associated subtypes of HLA-B27 (namely HLA-B*27:04 and HLA-B*27:05) but not to non-disease-associated subtypes (HLA-B*27:06 or HLA-B*27:09)...
September 7, 2016: Protein Journal
Lisa J Moran, Grant D Brinkworth, Sean Martin, Thomas P Wycherley, Bronwyn Stuckey, Janna Lutze, Peter M Clifton, Gary A Wittert, Manny Noakes
INTRODUCTION: Obesity is associated with reduced testosterone and worsened erectile and sexual function in men. Weight loss improves these outcomes. High protein diets potentially offer anthropometric and metabolic benefits, but their effects on reproductive and sexual outcomes is not known. AIM: To examine the long-term effects of weight loss with a higher protein or carbohydrate diet on testosterone, sex hormone binding globulin, erectile dysfunction, lower urinary tract symptoms and sexual desire in overweight and obese men...
2016: PloS One
Vincenzo Parisi, Lucia Ziccardi, Gloria Roberti, Lucia Tanga, Gianluca Manni
No abstract text is available yet for this article.
2016: Frontiers in Aging Neuroscience
Neel K Gupta, Amber Nolan, Antonio Omuro, Erin G Reid, Chia-Ching Wang, Gabriel Mannis, Michael Jaglal, Julio C Chavez, Paul G Rubinstein, Ann Griffin, Donald I Abrams, Jimmy Hwang, Lawrence D Kaplan, Judith A Luce, Paul Volberding, Patrick A Treseler, James L Rubenstein
BACKGROUND: The optimal therapeutic approach for patients with AIDS-related primary central nervous system lymphoma (AR-PCNSL) remains undefined. While its incidence declined substantially with combination antiretroviral therapy (cART), AR-PCNSL remains a highly aggressive neoplasm for which whole brain radiotherapy (WBRT) is considered a standard first-line intervention. METHODS: To identify therapy-related factors associated with favorable survival, we first retrospectively analyzed outcomes of AR-PCNSL patients treated at San Francisco General Hospital, a public hospital with a long history of dedicated care for patients with HIV and AIDS-related malignancies...
August 30, 2016: Neuro-oncology
Ruth E Manny, Li Deng, Jane Gwiazda, Leslie Hyman, Erik Weissberg, Mitchell Scheiman, Karen D Fern
PURPOSE: To examine internal astigmatism (IA) in myopes and non-myopes using a new method to assess compensation of corneal astigmatism (CA) by IA, to look for predictors of high IA in young adult myopes, and to determine if as CA changes IA changes to reduce refractive astigmatism (RA) in an active compensatory process in myopes. METHODS: Right eye keratometry and cycloplegic autorefraction were measured annually over 14 years in 367 myopes and once in 204 non-myopes age- (mean 21...
September 2016: Optometry and Vision Science: Official Publication of the American Academy of Optometry
Matthew P Mulé, Gabriel N Mannis, Brent L Wood, Jerald P Radich, Jimmy Hwang, Nestor R Ramos, Charalambos Andreadis, Lloyd Damon, Aaron C Logan, Thomas G Martin, Christopher S Hourigan
We report here the largest study to date of adult patients with acute myeloid leukemia (AML) tested for measurable residual disease (MRD) at the time of autologous hematopoietic cell transplantation (auto-HCT). Seventy-two adult patients who underwent transplantation between 2004 and 2013 at a single academic medical center (University of California San Francisco) were eligible for this retrospective study based on availability of cryopreserved granulocyte colony-stimulating factor (GCSF)-mobilized autologous peripheral blood progenitor cell (PBPC) leukapheresis specimens ("autografts")...
November 2016: Biology of Blood and Marrow Transplantation
Diego Carrella, Isabella Manni, Barbara Tumaini, Rosanna Dattilo, Federica Papaccio, Margherita Mutarelli, Francesco Sirci, Carla A Amoreo, Marcella Mottolese, Manuela Iezzi, Laura Ciolli, Valentina Aria, Roberta Bosotti, Antonella Isacchi, Fabrizio Loreni, Alberto Bardelli, Vittorio E Avvedimento, Diego di Bernardo, Luca Cardone
The discovery of inhibitors for oncogenic signalling pathways remains a key focus in modern oncology, based on personalized and targeted therapeutics. Computational drug repurposing via the analysis of FDA-approved drug network is becoming a very effective approach to identify therapeutic opportunities in cancer and other human diseases. Given that gene expression signatures can be associated with specific oncogenic mutations, we tested whether a "reverse" oncogene-specific signature might assist in the computational repositioning of inhibitors of oncogenic pathways...
August 16, 2016: Oncotarget
E Alfonsi, M Terzaghi, G Cosentino, C Tassorelli, R Manni, N Pozzi, R De Icco, G Bertino, M Todisco, E Alvisi, M Fresia, C Pacchetti, R Zangaglia, P Prunetti, A Moglia
BACKGROUND: Nocturnal stridor and respiratory abnormalities are important features of multiple system atrophy (MSA) with relevance to patient survival, and they are detected and evaluated mainly through video-polysomnography (video-PSG). Diurnal laryngoscopy seems to yield abnormal findings only in the presence of significant vocal cord (VC) dysfunction. AIM: To assess whether specific electrophysiological patterns of diurnal EMG of VC muscles may indicate nocturnal stridor or respiratory dysfunctions in MSA patients...
October 2016: Parkinsonism & related Disorders
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