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Paola Proserpio, Michele Terzaghi, Raffaele Manni, Lino Nobili
Patient education and behavioral management represent the first treatment approaches to the patient with parasomnia, especially in case of disorders of arousal (DOA). A pharmacologic treatment of DOA may be useful when episodes are frequent and persist despite resolution of predisposing factors, are associated with a high risk of injury, or cause significant impairment, such as excessive sleepiness. Approved drugs for DOA are still lacking. The most commonly used medications are benzodiazepines and antidepressants...
June 2018: Sleep Medicine Clinics
Katariina Manni, Marketta Rinne, Arto Huuskonen, Pekka Huhtanen
The objective was to examine the effects of concentrate level (barley grain 39 and 74 g dry matter/kg0.60 live weight) and allocation regime (steady, increased, decreased) on meat quality of growing dairy bulls fed grass silage ad libitum. Chemical, instrumental and sensory analyses were used for measuring quality of longissimus lumborum (LL). Greater concentrate level increased fat content (P = 0.035) and tenderness of sensory analysis (P = 0.009) of LL but did not affect pH, colour, drip loss, sarcomere length, shear force, juiciness or flavour...
April 30, 2018: Meat Science
Mark J Mannis, Joel Sugar
No abstract text is available yet for this article.
May 8, 2018: Cornea
Jemima Albayda, Lisa Christopher-Stine, Clifton O Bingham Iii, Julie J Paik, Eleni Tiniakou, Seth Billings, O Manny Uy, Philippe Burlina
OBJECTIVES: Imaging plays a role in myositis assessment by detecting muscle changes indicative of pathology. This study was conducted to determine the ultrasonographic pattern of muscle involvement in patients with inclusion body myositis (IBM) through an assessment of muscle echointensity. METHODS: Sixty-two individuals were consecutively studied, 18 with IBM, 16 with polymyositis or dermatomyositis and 28 normal controls. Standardised scans were completed bilaterally for the deltoids, biceps, flexor digitorum profundus (FDP), flexor carpi ulnaris, rectus femoris, tibialis anterior and gastrocnemius assessing for muscle echointensity changes...
May 8, 2018: Clinical and Experimental Rheumatology
Shakila Thangaratinam, Nadine Marlin, Sian Newton, Annalise Weckesser, Manny Bagary, Lynette Greenhill, Rachel Rikunenko, Maria D'Amico, Ewelina Rogozińska, Andrew Kelso, Kelly Hard, Jamie Coleman, Ngawai Moss, Tracy Roberts, Lee Middleton, Julie Dodds, Angela Pullen, Sandra Eldridge, Alexander Pirie, Elaine Denny, Doug McCorry, Khalid S Khan
BACKGROUND: Pregnant women with epilepsy on antiepileptic drugs (AEDs) may experience a reduction in serum AED levels. This has the potential to worsen seizure control. OBJECTIVE: To determine if, in pregnant women with epilepsy on AEDs, additional therapeutic drug monitoring reduces seizure deterioration compared with clinical features monitoring after a reduction in serum AED levels. DESIGN: A double-blind, randomised trial nested within a cohort study was conducted and a qualitative study of acceptability of the two strategies was undertaken...
May 2018: Health Technology Assessment: HTA
Yihunie Hibstie Asres, Manny Mathuthu, Marelgn Derso Birhane
This study provides current evidence about cross-section production processes in the theoretical and experimental results of neutron induced reaction of uranium isotope on projectile energy range of 1-100 MeV in order to improve the reliability of nuclear stimulation. In such fission reactions of 235 U within nuclear reactors, much amount of energy would be released as a product that able to satisfy the needs of energy to the world wide without polluting processes as compared to other sources. The main objective of this work is to transform a related knowledge in the neutron-induced fission reactions on 235 U through describing, analyzing and interpreting the theoretical results of the cross sections obtained from computer code COMPLET by comparing with the experimental data obtained from EXFOR...
April 22, 2018: Applied Radiation and Isotopes
D R Klein, D MacNeill, J L Lado, D Soriano, E Navarro-Moratalla, K Watanabe, T Taniguchi, S Manni, P Canfield, J Fernández-Rossier, P Jarillo-Herrero
Magnetic insulators are a key resource for next-generation spintronic and topological devices. The family of layered metal halides promises varied magnetic states including ultrathin insulating multiferroics, spin liquids, and ferromagnets, but device-oriented characterization methods are needed to unlock their potential. Here, we report tunneling through the layered magnetic insulator CrI3 as a function of temperature and applied magnetic field. We electrically detect the magnetic ground state and inter-layer coupling and observe a field-induced metamagnetic transition...
May 3, 2018: Science
Gilly A Hendrie, Megan A Rebuli, Rebecca K Golley, Manny Noakes
BACKGROUND: Methods to address misreporting associated with short dietary assessment instruments are needed. OBJECTIVE: Our objective was to develop and evaluate the direct and indirect validity of adjustment factors applied to a short dietary assessment instrument to improve estimates of usual consumption of core and discretionary food and beverage intake. DESIGN: Validation of the Short Food Survey relative to 24-hour recalls was performed...
May 1, 2018: Journal of the Academy of Nutrition and Dietetics
Preci Hamilton, Imad Soryal, Prince Dhahri, Welege Wimalachandra, Anna Leat, Denise Hughes, Nicole Toghill, James Hodson, Vijay Sawlani, Tom Hayton, Shanika Samarasekera, Manny Bagary, Dougall McCorry, Ramesh Chelvarajah
PURPOSE: To compare the efficacy of AspireSR® to preceding VNS battery models for battery replacements, and to determine the efficacy of the AspireSR® for new implants. METHODS: Data were collected retrospectively from patients with epilepsy who had VNS AspireSR® implanted over a three-year period between June 2014 and June 2017 by a single surgeon. Cases were divided into two cohorts, those in whom the VNS was a new insertion, and those in whom the VNS battery was changed from a previous model to AspireSR® ...
March 28, 2018: Seizure: the Journal of the British Epilepsy Association
Gloria Roberti, Luca Agnifili, Francesca Berardo, Ivano Riva, Michele Figus, Gianluca Manni, Luciano Quaranta, Francesco Oddone
INTRODUCTION: To compare the effects of a preservative-free (PF) ophthalmic solution containing hyaluronic acid (HA) 0.4% and taurine (TAU) 0.5% with those of a PF ophthalmic solution containing HA 0.2% on ocular surface signs, symptoms, and morphological parameters in glaucoma patients under multiple long-term topical hypotensive therapy. METHODS: Eligible patients underwent evaluation of ocular surface parameters by ocular surface disease index (OSDI) and glaucoma symptom scale (GSS) questionnaires, breakup time test (BUT), Schirmer I test, corneal and conjunctival staining (Oxford scale), and conjunctival in vivo confocal microscopy (Heidelberg Retina Tomograph 3, Heidelberg Engineering GmbH, Heidelberg, Germany)...
April 23, 2018: Advances in Therapy
Hui Yu, Wenwen Jing, Rafael Iriya, Yunze Yang, Karan Syal, Manni Mo, Thomas E Grys, Shelley E Haydel, Shaopeng Wang, Nongjian Tao
Timely determination of antimicrobial susceptibility for a bacterial infection enables precision prescription, shortens treatment time and helps minimize the spread of antibiotic resistant infections. Current antimicrobial susceptibility testing (AST) methods often take several days and thus impede these clinical and health benefits. Here, we present an AST method by imaging freely moving bacterial cells in urine in real time and analyzing the videos with a deep learning algorithm. The deep learning algorithm determines if an antibiotic inhibits a bacterial cell by learning multiple phenotypic features of the cell without the need for defining and quantifying each feature...
April 20, 2018: Analytical Chemistry
Leila C Kahwati, Rachel Palmieri Weber, Huiling Pan, Margaret Gourlay, Erin LeBlanc, Manny Coker-Schwimmer, Meera Viswanathan
Importance: Osteoporotic fractures result in significant morbidity and mortality. Objective: To update the evidence for benefits and harms of vitamin D, calcium, or combined supplementation for the primary prevention of fractures in community-dwelling adults to inform the US Preventive Services Task Force. Data Sources: PubMed, EMBASE, Cochrane Library, and trial registries through March 21, 2017; references; and experts. Surveillance continued through February 28, 2018...
April 17, 2018: JAMA: the Journal of the American Medical Association
Massimo Federico, Monica Bellei, Luigi Marcheselli, Marc Schwartz, Martina Manni, Vittoria Tarantino, Stefano Pileri, Young-Hyeh Ko, Maria E Cabrera, Steven Horwitz, Won S Kim, Andrei Shustov, Francine M Foss, Arnon Nagler, Kenneth Carson, Lauren C Pinter-Brown, Silvia Montoto, Michele Spina, Tatyana A Feldman, Mary J Lechowicz, Sonali M Smith, Frederick Lansigan, Raul Gabus, Julie M Vose, Ranjana H Advani
Different models to investigate the prognosis of peripheral T cell lymphoma not otherwise specified (PTCL-NOS) have been developed by means of retrospective analyses. Here we report on a new model designed on data from the prospective T Cell Project. Twelve covariates collected by the T Cell Project were analysed and a new model (T cell score), based on four covariates (serum albumin, performance status, stage and absolute neutrophil count) that maintained their prognostic value in multiple Cox proportional hazards regression analysis was proposed...
April 19, 2018: British Journal of Haematology
Emily Brindal, Gilly A Hendrie, Jill Freyne, Manny Noakes
BACKGROUND: Mobile phone apps may be acceptable to users and could improve retention and adherence over more traditional methods, but there is mixed literature supporting their efficacy. In the weight management space, very little is known about how a mobile phone app integrating features beyond text messaging (short message service) can affect behavior, particularly when combined with face-to-face support. OBJECTIVE: The objective of this study was to examine the effectiveness of a mobile phone app when combined with a partial meal replacement program including face-to-face support...
April 18, 2018: JMIR MHealth and UHealth
Ling Zhang, Qianqian Qin, Manni Liu, Xiangling Zhang, Fang He, Guoqing Wang
This study aimed to investigate how Akkermansia muciniphila can implicate type 2 diabetes mellitus and the mechanisms underlying the effects Akkermansia muciniphila on type 2 diabetes mellitus. Normal and streptozotocin-induced diabetic Sprague-Dawley rats were orally administered with Akkermansia muciniphila and solvent. After four weeks of treatment, diabetic rats orally administered with live or pasteurized Akkermansia muciniphila exhibited significant increase in the blood concentration of high-density lipoprotein, and decrease in the hepatic glycogen, serum plasminogen activator inhibitor-1, tumor necrosis factor-α, lipopolysaccharide, malondialdehyde, and total glucagon-like peptide-1...
April 16, 2018: Pathogens and Disease
Andrea Schiavone, Michele Bisaccia, Ivan Inkov, Giuseppe Rinonapoli, Mattia Manni, Giuseppe Rollo, Luigi Meccariello, Cristina Ibáñez Vicente, Paolo Ceccarini, Carmelinda Ruggiero, Auro Caraffa
BACKGROUND: There is a high incidence of blood transfusion following hip fractures in elderly patients. AIM: The aim of this study is to evaluate the effectiveness and complications of use of tranexamic acid in proximal femur nailing surgery. MATERIALS AND METHODS: Our sample group consisted of 90 patients suffering from pertrochanteric fractures surgically treated with osteosynthesis with SupernailGT(LimaCorporate). The classification system AO/OTA was used to divide the fractures into 31A1 (n=45) and 31A2 (n=45)...
March 1, 2018: Folia Medica
Maria Luisa Rocco, Marzia Soligo, Luigi Manni, Luigi Aloe
Since its discovery, nerve growth factor (NGF) has long occupied a critical role in developmental and adult neurobiology for its many important regulatory functions on the survival, growth and differentiation of nerve cells in the peripheral and central nervous system. NGF is the first discovered member of a family of neurotrophic factors, collectively indicated as neurotrophins, (which include brain-derived neurotrophic factor, neurotrophin-3 and neurotrophin 4/5). NGF was discovered for its action on the survival and differentiation of selected populations of peripheral neurons...
April 11, 2018: Current Neuropharmacology
Alenka Čopič, Sandra Antoine-Bally, Manuel Giménez-Andrés, César La Torre Garay, Bruno Antonny, Marco M Manni, Sophie Pagnotta, Jeanne Guihot, Catherine L Jackson
How proteins are targeted to lipid droplets (LDs) and distinguish the LD surface from the surfaces of other organelles is poorly understood, but many contain predicted amphipathic helices (AHs) that are involved in targeting. We have focused on human perilipin 4 (Plin4), which contains an AH that is exceptional in terms of length and repetitiveness. Using model cellular systems, we show that AH length, hydrophobicity, and charge are important for AH targeting to LDs and that these properties can compensate for one another, albeit at a loss of targeting specificity...
April 6, 2018: Nature Communications
Sabrina Manni, Marilena Carrino, Francesco Piazza
The original article [1] contains an inadvertent error in the following sentence in the Abstract regarding the erroneous description of Ser/Thr kinases as 'phylogenetically related'.
April 5, 2018: Journal of Hematology & Oncology
Gretl Hendrickx, Vere M Borra, Ellen Steenackers, Timur A Yorgan, Christophe Hermans, Eveline Boudin, Jérôme J Waterval, Ineke D C Jansen, Tolunay Beker Aydemir, Niels Kamerling, Geert J Behets, Christine Plumeyer, Patrick C D'Haese, Björn Busse, Vincent Everts, Martin Lammens, Geert Mortier, Robert J Cousins, Thorsten Schinke, Robert J Stokroos, Johannes J Manni, Wim Van Hul
Hyperostosis Cranialis Interna (HCI) is a rare bone disorder characterized by progressive intracranial bone overgrowth at the skull. Here we identified by whole-exome sequencing a dominant mutation (L441R) in SLC39A14 (ZIP14). We show that L441R ZIP14 is no longer trafficked towards the plasma membrane and excessively accumulates intracellular zinc, resulting in hyper-activation of cAMP-CREB and NFAT signaling. Conditional knock-in mice overexpressing L438R Zip14 in osteoblasts have a severe skeletal phenotype marked by a drastic increase in cortical thickness due to an enhanced endosteal bone formation, resembling the underlying pathology in HCI patients...
April 5, 2018: PLoS Genetics
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