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https://www.readbyqxmd.com/read/29343728/oxidation-of-sqstm1-p62-mediates-the-link-between-redox-state-and-protein-homeostasis
#1
Bernadette Carroll, Elsje G Otten, Diego Manni, Rhoda Stefanatos, Fiona M Menzies, Graham R Smith, Diana Jurk, Niall Kenneth, Simon Wilkinson, Joao F Passos, Johannes Attems, Elizabeth A Veal, Elisa Teyssou, Danielle Seilhean, Stéphanie Millecamps, Eeva-Liisa Eskelinen, Agnieszka K Bronowska, David C Rubinsztein, Alberto Sanz, Viktor I Korolchuk
Cellular homoeostatic pathways such as macroautophagy (hereinafter autophagy) are regulated by basic mechanisms that are conserved throughout the eukaryotic kingdom. However, it remains poorly understood how these mechanisms further evolved in higher organisms. Here we describe a modification in the autophagy pathway in vertebrates, which promotes its activity in response to oxidative stress. We have identified two oxidation-sensitive cysteine residues in a prototypic autophagy receptor SQSTM1/p62, which allow activation of pro-survival autophagy in stress conditions...
January 17, 2018: Nature Communications
https://www.readbyqxmd.com/read/29313658/lipidic-mesophases-as-novel-nanoreactor-scaffolds-for-organocatalysts-heterogeneously-catalyzed-asymmetric-aldol-reactions-in-confined-water
#2
Michael Duss, Livia Salvati Manni, Laurent Moser, Stephan Handschin, Raffaele Mezzenga, Henning J Jessen, Ehud M Landau
The unique molecular architecture of lipidic cubic phases (LCPs) and their cubosome dispersions comprise a well-defined, curved bilayer that spans the entire 3-D material space, encompassing a network of two periodic, curved and non-intersecting three-dimensional aqueous channels. The ensuing large lipid/water interfacial area renders these biomaterials an interesting matrix for the lateral immobilization of organocatalysts to catalyze organic reactions in confined water. Herein, we report for the first time the design, synthesis, assembly and characterization of catalytically active LCPs and cubosomes, and demonstrate their applicability as self-assembled, biomimetic and recyclable nanoreactor scaffolds...
January 9, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29311165/night-shift-work-increases-the-risks-of-multiple-primary-cancers-in-women-a-systematic-review-and-meta-analysis-of-61-articles
#3
REVIEW
Xia Yuan, Chenjing Zhu, Manni Wang, Fei Mo, Wei Du, Xuelei Ma
A growing number of studies have examined associations between night shift work and the risks of common cancers among women, with varying conclusions. We did a meta-analysis to identify whether long-term night shift work increased the risks of common cancers in women. We enrolled 61 articles involving 114,628 cases and 3,909,152 participants from Europe, North America, Asia, and Australia. Risk estimates were performed with a random-effect model or a fixed-effect model. Subgroup analyses and meta-regression analyses about breast cancer were conducted to explore possible sources of heterogeneity...
January 2018: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/29306173/blocking-osteopontin-fibronectin-interactions-reduce-extracellular-fibronectin-deployment-and-arthritic-immunopathology
#4
Brij Bhushan Mehta, Saniya Sharma, Rakesh K Vasishta, Ramesh K Sen, Aman Sharma, Manni Luthra-Guptasarma
Elevated levels of a thrombin-cleaved fragment of osteopontin (OPNT) are seen in synovial fluid (SF) and tissues of rheumatoid arthritis (RA) patients. OPNT binds to integrins on cell surfaces, inducing adhesion, migration and survival of inflammatory cells in the synovial joints, where OPNT binds to fibronectin to link fibroblast-like synoviocytes (FLS) with B cells, stimulating the latter to produce inflammatory cytokines. Our aim was to block OPNT-fibronectin interactions and examine whether this reduces inflammation...
January 3, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29299929/proteome-of-bovine-mitochondria-and-rod-outer-segment-disks-commonalities-and-differences
#5
Maurizio Bruschi, Andrea Petretto, Federico Caicci, Martina Bartolucci, Daniela Calzia, Laura Santucci, Lucia Manni, Luca A Ramenghi, Gian Marco Ghiggeri, Carlo E Traverso, Giovanni Candiano, Isabella Panfoli
The retinal rod outer segment (OS) is a stack of disks surrounded by the plasma membrane, housing proteins related to phototransduction, as well as mitochondrial proteins involved in oxidative phosphorylation (OxPhos). This prompted us to compare the proteome of bovine OS disks and mitochondria, to assess the significant top gene signatures of each sample. The two proteomes, obtained by LTQ-Orbitrap Velos mass spectrometry, were compared by statistical analyses. 4139 proteins were identified, 2045 of which overlapping in the two sets...
January 4, 2018: Journal of Proteome Research
https://www.readbyqxmd.com/read/29277977/developmental-signature-synaptic-connectivity-and-neurotransmission-are-conserved-between-vertebrate-hair-cells-and-tunicate-coronal-cells
#6
Francesca Rigon, Fabio Gasparini, Sebastian M Shimeld, Simona Candiani, Lucia Manni
In tunicates, the coronal organ represents a sentinel checking particle entrance into the pharynx. The organ differentiates from an anterior embryonic area considered a proto-placode. For their embryonic origin, morphological features and function, coronal sensory cells have been hypothesized to be homologues to vertebrate hair cells. However, vertebrate hair cells derive from a posterior placode. This contradicts one of the principle historical criteria for homology, similarity of position, which could be taken as evidence against coronal cells/hair cells homology...
December 26, 2017: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/29245522/fixation-description-and-dna-barcode-of-a-neotype-for-i-botryllus-schlosseri%C3%A2-i-pallas-1766-tunicata-ascidiacea
#7
Riccardo Brunetti, Lucia Manni, Francesco Mastrototaro, Carmela Gissi, Fabio Gasparini
Botryllus schlosseri is a widespread colonial ascidian commonly considered cosmopolitan and amply used as model for researches ranging from developmental biology to immunobiology. Recently, molecular data lead to hypothesize that the species named B. schlosseri may consist of more than a single taxon. Indeed, five highly divergent clades, named A-E, have been genetically identified and are referred as cryptic species. In this context, and lacking both a type and a detailed morphological description, we believe that it is necessary, as a taxonomic reference point, to designate a neotype and re-describe the species...
November 22, 2017: Zootaxa
https://www.readbyqxmd.com/read/29235272/real-time-detection-of-antibiotic-activity-by-measuring-nanometer-scale-bacterial-deformation
#8
Rafael Iriya, Karan Syal, Wenwen Jing, Manni Mo, Hui Yu, Shelley E Haydel, Shaopeng Wang, Nongjian Tao
Diagnosing antibiotic-resistant bacteria currently requires sensitive detection of phenotypic changes associated with antibiotic action on bacteria. Here, we present an optical imaging-based approach to quantify bacterial membrane deformation as a phenotypic feature in real-time with a nanometer scale (∼9  nm) detection limit. Using this approach, we found two types of antibiotic-induced membrane deformations in different bacterial strains: polymyxin B induced relatively uniform spatial deformation of Escherichia coli O157:H7 cells leading to change in cellular volume and ampicillin-induced localized spatial deformation leading to the formation of bulges or protrusions on uropathogenic E...
December 2017: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/29226254/empirical-treatment-of-bacterial-keratitis-an-international-survey-of-corneal-specialists
#9
Ariana Austin, Julie Schallhorn, Mike Geske, Mark Mannis, Tom Lietman, Jennifer Rose-Nussbaumer
Background/aims: New antibiotic agents and changing susceptibility patterns may have changed the empirical treatment of bacterial keratitis. Our objective in this study was to survey cornea specialists' practice patterns in the initial treatment of bacterial ulcers. Methods: This study consisted of a short online survey emailed to members of the Cornea Society listserv for an international sample of cornea specialists. Data collection began July 2014 and ended October 2014...
August 2017: BMJ open ophthalmology
https://www.readbyqxmd.com/read/29220515/busco-applications-from-quality-assessments-to-gene-prediction-and-phylogenomics
#10
Robert M Waterhouse, Mathieu Seppey, Felipe A Simão, Mosè Manni, Panagiotis Ioannidis, Guennadi Klioutchnikov, Evgenia V Kriventseva, Evgeny M Zdobnov
Genomics promises comprehensive surveying of genomes and metagenomes, but rapidly changing technologies and expanding data volumes make evaluation of completeness a challenging task. Technical sequencing quality metrics can be complemented by quantifying completeness of genomic datasets in terms of the expected gene content of Benchmarking Universal Single-Copy Orthologs (BUSCO, http://busco.ezlab.org). The latest software release implements a complete refactoring of the code to make it more flexible and extendable to facilitate high-throughput assessments...
December 6, 2017: Molecular Biology and Evolution
https://www.readbyqxmd.com/read/29215397/keratoconus-and-personality-a-review
#11
Mark J Mannis, Jennifer J Ling, Ralph Kyrillos, Melissa Barnett
PURPOSE: To assess the existing literature on the subject of keratoconus and personality and to propose a theory that might account for the perceived personality changes associated with this condition. METHODS: A literature search was conducted in the PubMed database using the term "keratoconus" in combination with keywords such as personality, psychiatry, psychology, anxiety, depression, or psychosis. A total of 15 articles pertaining to personality and psychiatric disorders in keratoconus were retained and reviewed...
December 5, 2017: Cornea
https://www.readbyqxmd.com/read/29215037/pre-treatment-inflammatory-indexes-as-predictors-of-survival-and-cetuximab-efficacy-in-metastatic-colorectal-cancer-patients-with-wild-type-ras
#12
Jing Yang, Xinli Guo, Manni Wang, Xuelei Ma, Xiaoyang Ye, Panpan Lin
This study aims at evaluating the prognostic significance of neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), and systemic immune-inflammation indexes (SII) in metastatic colorectal cancer (mCRC) patients treated with cetuximab. Ninety-five patients receiving cetuximab for mCRC were categorized into the high or low NLR, PLR, LMR, and SII groups based on their median index values. Univariate and multivariate survival analysis were performed to identify the indexes' correlation with progression-free survival (PFS) and overall survival (OS)...
December 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29178536/effects-of-an-energy-restricted-low-carbohydrate-high-unsaturated-fat-low-saturated-fat-diet-versus-a-high-carbohydrate-low-fat-diet-in-type-2-diabetes-a-2-year-randomized-clinical-trial
#13
Jeannie Tay, Campbell H Thompson, Natalie D Luscombe-Marsh, Thomas P Wycherley, Manny Noakes, Jonathan D Buckley, Gary A Wittert, William S Yancy, Grant D Brinkworth
AIM: To examine whether a low-carbohydrate, high unsaturated/low saturated fat diet (LC) improves glycemic control and cardiovascular disease (CVD) risk factors in overweight and obese patients with type 2 diabetes (T2D). METHODS: 115 adults with T2D (mean[SD]; BMI:34.6[4.3]kg/m2 , age:58[7]yrs, HbA1c:7.3[1.1]%) were randomized to one of two planned energy-matched, hypocaloric diets combined with aerobic/resistance exercise (1hr,3d/wk) for 2 years:(1) LC:14% energy as carbohydrate, 28% protein, 58% fat [<10% saturated fat]) or (2) low fat, high-carbohydrate, low glycemic index diet (HC):53% CHO, 17% protein, 30% fat [<10% saturated fat])...
November 27, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29141975/dietary-strategies-to-reduce-environmental-impact-a-critical-review-of-the-evidence-base
#14
REVIEW
Bradley G Ridoutt, Gilly A Hendrie, Manny Noakes
The food system is a major source of environmental impact, and dietary change has been recommended as an important and necessary strategy to reduce this impact. However, assessing the environmental performance of diets is complex due to the many types of foods eaten and the diversity of agricultural production systems and local environmental settings. To assess the state of science and identify knowledge gaps, an integrative review of the broad topic of environment and diet was undertaken, with particular focus on the completeness of coverage of environmental concerns and the metrics used...
November 2017: Advances in Nutrition
https://www.readbyqxmd.com/read/29127333/a-light-activated-antimicrobial-surface-is-active-against-bacterial-viral-and-fungal-organisms
#15
Tim Walker, Melisa Canales, Sacha Noimark, Kristopher Page, Ivan Parkin, Jane Faull, Manni Bhatti, Lena Ciric
Evidence has shown that environmental surfaces play an important role in the transmission of nosocomial pathogens. Deploying antimicrobial surfaces in hospital wards could reduce the role environmental surfaces play as reservoirs for pathogens. Herein we show a significant reduction in viable counts of Staphylococcus epidermidis, Saccharomyces cerevisiae, and MS2 Bacteriophage after light treatment of a medical grade silicone incorporating crystal violet, methylene blue and 2 nm gold nanoparticles. Furthermore, a migration assay demonstrated that in the presence of light, growth of the fungus-like organism Pythium ultimum and the filamentous fungus Botrytis cinerea was inhibited...
November 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29121153/evolution-of-practice-patterns-for-the-treatment-of-fungal-keratitis
#16
(no author information available yet)
No abstract text is available yet for this article.
December 1, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/29102687/rosacea-comorbidities-and-future-research-the-2017-update-by-the-national-rosacea-society-expert-committee
#17
EDITORIAL
Richard L Gallo, Richard D Granstein, Sewon Kang, Mark Mannis, Martin Steinhoff, Jerry Tan, Diane Thiboutot
No abstract text is available yet for this article.
January 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29101835/blending-virtual-with-conventional-learning-to-improve-student-midwifery-skills-in-india
#18
Sudharsanam Manni Balasubramaniam, Saurabh Bhargava, Neeraj Agrawal, Rashmi Asif, Lalhmangaihi Chawngthu, Pallavi Sinha, Somesh Kumar, Bulbul Sood
India's state of Bihar has suboptimal quality of pre-service training for auxiliary nurse midwives. To address this, state government of Bihar implemented a blended training model to supplement conventional classroom teaching with virtual training. A 72-hour virtual training package with updated content on key maternal and newborn health practices was developed for final year students and broadcasted from one instructor location simultaneously to two auxiliary nurse midwives training centres. This pre-post intervention study compared skills of two auxiliary nurse midwife student cohorts...
October 23, 2017: Nurse Education in Practice
https://www.readbyqxmd.com/read/29095677/long-term-results-of-the-foll05-trial-comparing-r-cvp-versus-r-chop-versus-r-fm-for-the-initial-treatment-of-patients-with-advanced-stage-symptomatic-follicular-lymphoma
#19
Stefano Luminari, Angela Ferrari, Martina Manni, Alessandra Dondi, Annalisa Chiarenza, Francesco Merli, Chiara Rusconi, Vittoria Tarantino, Alessandra Tucci, Umberto Vitolo, Sofia Kovalchuk, Emanuele Angelucci, Alessandro Pulsoni, Luca Arcaini, Francesco Angrilli, Gianluca Gaidano, Caterina Stelitano, Giovanni Bertoldero, Nicola Cascavilla, Flavia Salvi, Andrés J M Ferreri, Daniele Vallisa, Luigi Marcheselli, Massimo Federico
Purpose The FOLL05 trial compared R-CVP (rituximab plus cyclophosphamide, vincristine, and prednisone) with R-CHOP (rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone) and R-FM (rituximab plus fludarabine and mitoxantrone) regimens without rituximab maintenance as initial therapy for patients with advanced-stage follicular lymphoma (FL). A previous analysis with a median follow-up of 34 months showed a superior 3-year time to treatment failure, the primary study end point, with R-CHOP and R-FM versus R-CVP and showed R-CHOP to have a better risk-benefit ratio in terms of toxicity than R-FM...
November 2, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29089180/standard-classification-and-pathophysiology-of-rosacea-the-2017-update-by-the-national-rosacea-society-expert-committee
#20
REVIEW
Richard L Gallo, Richard D Granstein, Sewon Kang, Mark Mannis, Martin Steinhoff, Jerry Tan, Diane Thiboutot
In 2002, the National Rosacea Society assembled an expert committee to develop the first standard classification of rosacea. This original classification was intended to be updated as scientific knowledge and clinical experience increased. Over the last 15 years, significant new insights into rosacea's pathogenesis and pathophysiology have emerged, and the disorder is now widely addressed in clinical practice. Growing knowledge of rosacea's pathophysiology has established that a consistent multivariate disease process underlies the various clinical manifestations of this disorder, and the clinical significance of each of these elements is increasing as more is understood...
January 2018: Journal of the American Academy of Dermatology
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