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https://www.readbyqxmd.com/read/28644984/current-practice-and-recommendations-in-uk-epilepsy-monitoring-units-report-of-a-national-survey-and-workshop
#1
Khalid Hamandi, Sandor Beniczky, Beate Diehl, Rosalind H Kandler, Ronit M Pressler, Arjune Sen, Juliet Solomon, Matthew C Walker, Manny Bagary
PURPOSE: Inpatient video-EEG monitoring (VEM) is an important investigation in patients with seizures or blackouts, and in the pre-surgical workup of patients with epilepsy. There has been an expansion in the number of Epilepsy Monitoring Units (EMU) in the UK offering VEM with a necessary increase in attention on quality and safety. Previous surveys have shown variation across centres on issues including consent and patient monitoring. METHOD: In an effort to bring together healthcare professionals in the UK managing patients on EMU, we conducted an online survey of current VEM practice and held a one-day workshop convened under the auspices of the British Chapter of the ILAE...
June 15, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/28638468/current-and-emerging-techniques-for-antibiotic-susceptibility-tests
#2
REVIEW
Karan Syal, Manni Mo, Hui Yu, Rafael Iriya, Wenwen Jing, Sui Guodong, Shaopeng Wang, Thomas E Grys, Shelley E Haydel, Nongjian Tao
Infectious diseases caused by bacterial pathogens are a worldwide burden. Serious bacterial infection-related complications, such as sepsis, affect over a million people every year with mortality rates ranging from 30% to 50%. Crucial clinical microbiology laboratory responsibilities associated with patient management and treatment include isolating and identifying the causative bacterium and performing antibiotic susceptibility tests (ASTs), which are labor-intensive, complex, imprecise, and slow (taking days, depending on the growth rate of the pathogen)...
2017: Theranostics
https://www.readbyqxmd.com/read/28596474/lenalidomide-increases-human-dendritic-cell-maturation-in-multiple-myeloma-patients-targeting-monocyte-differentiation-and-modulating-mesenchymal-stromal-cell-inhibitory-properties
#3
Federica Costa, Rosanna Vescovini, Marina Bolzoni, Valentina Marchica, Paola Storti, Denise Toscani, Fabrizio Accardi, Laura Notarfranchi, Benedetta Dalla Palma, Cristina Manferdini, Sabrina Manni, Giannalisa Todaro, Gina Lisignoli, Francesco Piazza, Franco Aversa, Nicola Giuliani
The use of Lenalidomide (LEN), to reverse tumor-mediated immune suppression and amplify multiple myeloma-specific immunity is currently being explored. Particularly, LEN effects on dendritic cells (DCs) are still unclear. In this study, we investigated the potential effect of LEN on DC differentiation and activity. DCs were differentiated either from CD14+ cells obtained from patients with multiple myeloma or from a human monocytic cell line.LEN, at the concentration range reached in vivo, significantly increased the median intensity expression of HLA-DR, CD86 and CD209 by DCs derived from both bone marrow and peripheral myeloma monocytes and enhanced the production of Interleukin-8, C-C motif chemokine ligand (CCL) 2, CCL5 and tumor necrosis factor-α...
May 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28553423/corneal-refractive-procedures-for-the-treatment-of-presbyopia
#4
REVIEW
Kareem Moussa, Naz Jehangir, Tova Mannis, Wai L Wong, Majid Moshirfar
PURPOSE: Refractive surgery has been in use for a long time and is evolving at a fast pace with several new corneal procedures being used for the correction of presbyopia. The purpose of this article is to give a comprehensive review of the literature to evaluate the outcome and success of different corneal refractive surgical procedures in presbyopic patients. METHODS: We performed a comprehensive search on PubMed to identify published reports of the various procedures utilized in the past and present to correct presbyopia...
2017: Open Ophthalmology Journal
https://www.readbyqxmd.com/read/28516222/population-data-of-17-y-strs-yfiler-from-punjabis-and-kashmiris-of-pakistan
#5
Atif Adnan, Allah Rakha, Anum Noor, Mannis van Oven, Arwin Ralf, Manfred Kayser
Pakistan harbors 16 major ethnic groups including Punjabis (56% of total population) and Kashmiri (6% of total population). Here, we report data of 17 Y-chromosomal short tandem repeats (Y-STRs) genotyped with the AmpFlSTR Y-filer™ PCR Amplification kit in 94 Punjabis and 101 Kashmiris. The estimated haplotype diversity was higher in Punjabis (0.996) than that in Kashmiris (0.983). Furthermore, we performed population genetic analyses by including data from six other Pakistani groups. The presented haplotype data were recently included in the Y-Chromosome Haplotype Reference Database (YHRD) for future forensic and other usage...
May 17, 2017: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/28498441/radiolabeling-of-vegf165-with-99mtc-to-evaluate-vegfr-expression-in-tumor-angiogenesis
#6
Filippo Galli, Marco Artico, Samanta Taurone, Isabella Manni, Enrica Bianchi, Giulia Piaggio, Bruce D Weintraub, Mariusz W Szkudlinski, Enzo Agostinelli, Rudi A J O Dierckx, Alberto Signore
Angiogenesis is the main process responsible for tumor growth and metastatization. The principal effector of such mechanism is the vascular endothelial growth factor (VEGF) secreted by cancer cells and other components of tumor microenvironment. Radiolabeled VEGF analogues may provide a useful tool to noninvasively image tumor lesions and evaluate the efficacy of anti-angiogenic drugs that block the VEGFR pathway. Aim of the present study was to radiolabel the human VEGF165 analogue with 99mTechnetium (99mTc) and to evaluate the expression of VEGFR in both cancer and endothelial cells in the tumor microenvironment...
May 8, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28484297/reliability-feasibility-and-value-of-ecography-in-clinical-functional-results-in-patients-affected-by-carpal-tunnel-syndrome-is-there-a-correlation
#7
Mattia Manni, Michele Bisaccia, Giuseppe Rinonapoli, Andrea Schiavone, Luigi Meccariello, Steven James Mccabe, Olga Bisaccia, Cristina Ibáñez Vicente, Andrea Cappiello, Auro Caraffa
BACKGROUND: The aim of this study was to evaluate how the ultrasound examination in the carpal tunnel diagnosis could contribute to the clinical and neurophysiological evaluation. This was done by evaluating the cross-sectional area (CSA) and its correlation with symptoms and functionality data assessed by the BTQC questionnaire. METHODS: 60 patients were subjected to open CTR for idiopathic carpal tunnel syndrome. The median nerve CSA was assessed both pre-operatively and in follow-up at 4 and 12 weeks...
March 2017: Acta Informatica Medica: AIM
https://www.readbyqxmd.com/read/28458412/gas-chemical-adsorption-characterization-of-lanthanide-hexafluoroacetylacetonates
#8
S Adam Stratz, Steven J Jones, Austin D Mullen, Manny Mathuthu, Colton J Oldham, John D Auxier, Howard L Hall
Newly-established adsorption enthalpy and entropy values of 12 lanthanide hexafluoroacetylacetonates, denoted Ln[hfac]4, along with the experimental and theoretical methodology used to obtain these values, are presented for the first time. The results of this work can be used in conjunction with theoretical modeling techniques to optimize a large-scale gas-phase separation experiment using isothermal chromatography. The results to date indicate average adsorption enthalpy and entropy values of the 12 Ln[hfac]4 complexes ranging from -33 to -139 kJ/mol K and -299 to -557 J/mol, respectively...
2017: Journal of Radioanalytical and Nuclear Chemistry
https://www.readbyqxmd.com/read/28456302/label-free-quantitative-proteomic-analysis-of-inhibition-of-xanthomonas-axonopodis-pv-citri-by-the-novel-bactericide-fubianezuofeng
#9
Manni Gao, Lu Yu, Pei Li, Xianpeng Song, Zhuo Chen, Ming He, Baoan Song
To understand the antibacterial mechanism of the new bactericide 2-(methylsulfonyl)-5- (4-fluorobenzyl)-1, 3, 4-oxadiazole (Generic name: Fubianezuofeng), we performed label-free quantitative proteomics analysis of the response of Xanthomonas axonopodis pv. citri (Xac) strain 29-1 to Fubianezuofeng. A total of 1133 proteins were identified in the treatment and control groups. Upon treatment with the 1/2 minimum inhibitory concentration (MIC), 339 proteins were found to be differentially expressed (fold changes>1...
May 2017: Pesticide Biochemistry and Physiology
https://www.readbyqxmd.com/read/28449889/treating-sleep-apnea-in-parkinson-s-disease-with-c-pap-feasibility-concerns-and-effects-on-cognition-and-alertness
#10
Michele Terzaghi, Laura Spelta, Brigida Minafra, Valter Rustioni, Roberta Zangaglia, Claudio Pacchetti, Raffaele Manni
BACKGROUND: Obstructive sleep apnea (OSA) is highly prevalent in Parkinson disease (PD) and is known to contribute to cognitive impairment and daytime sleepiness. We investigated feasibility of continuous positive airway pressure treatment (CPAP) and its effects on subjective daytime sleepiness and cognitive profile in PD plus OSA subjects in a longitudinal three months follow up study. METHODS: Seventy (age 71.7 ± 7.6, disease duration 9.9 ± 12.3, UPDRS-III 33...
May 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28432899/serum-micrornas-related-with-chemoradiotherapy-resistance-in-advanced-stage-cervical-squamous-cell-carcinoma
#11
Ying Han, Mei Liu, Ziyi Wang, Manni Huang, Ningzhi Xu, Lingying Wu
OBJECTIVE: To investigate the serum microRNAs as biomarkers in predicting chemoradiotherapy resistance in advanced-stage cervical squamous cell carcinoma (ACSCC) patients. METHODS: Serum samples were collected from International Federation of Gynecology and Obstetrics (FIGO) stage IIB to IIIB cervical squamous cell carcinoma patients treated with platinum based Concomitant Chemoradiotherapy (CCRT) in our hospital during September 2013 to November 2015. Twenty well-matched samples (10 resistant and 10 sensitive) were chosen to screen the miRNA expression profile using serum samples pooled with microarrays...
June 2017: Translational Oncology
https://www.readbyqxmd.com/read/28429760/corrigendum-selective-targeting-of-hdac1-2-elicits-anticancer-effects-through-gli1-acetylation-in-preclinical-models-of-shh-medulloblastoma
#12
Sonia Coni, Anna Barbara Mancuso, Laura Di Magno, Giulia Sdruscia, Simona Manni, Silvia Maria Serrao, Dante Rotili, Eleonora Spiombi, Francesca Bufalieri, Marialaura Petroni, Monika Kusio-Kobialka, Enrico De Smaele, Elisabetta Ferretti, Carlo Capalbo, Antonello Mai, Pawel Niewiadomski, Isabella Screpanti, Lucia Di Marcotullio, Gianluca Canettieri
No abstract text is available yet for this article.
April 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28415563/gd2-expression-in-breast-cancer
#13
Giulia Orsi, Monica Barbolini, Guido Ficarra, Giovanni Tazzioli, Paola Manni, Tiziana Petrachi, Ilenia Mastrolia, Enrico Orvieto, Carlotta Spano, Malvina Prapa, Shaniko Kaleci, Roberto D'Amico, Valentina Guarneri, Maria Vittoria Dieci, Stefano Cascinu, Pierfranco Conte, Federico Piacentini, Massimo Dominici
Breast cancer (BC) is a heterogeneous disease, including different subtypes having diverse incidence, drug-sensitivity and survival rates. In particular, claudin-low and basal-like BC have mesenchymal features with a dismal prognosis. Disialoganglioside GD2 is a typical neuroectodermal antigen expressed in a variety of cancers. Despite its potential relevance in cancer diagnostics and therapeutics, the presence and role of GD2 require further investigation, especially in BC. Therefore, we evaluated GD2 expression in a cohort of BC patients and its correlation with clinical-pathological features...
May 9, 2017: Oncotarget
https://www.readbyqxmd.com/read/28395565/regression-of-methotrexate-resistant-aids-related-primary-central-nervous-system-lymphoma-with-lenalidomide-plus-combination-anti-retroviral-therapy
#14
Neel K Gupta, Chia-Ching Wang, Gabriel N Mannis, John-Paul J Yu, James L Rubenstein
No abstract text is available yet for this article.
April 10, 2017: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/28389184/les-%C3%A3-lastiques-intermaxillaires-%C3%A3-ancrage-osseux-dans-une-malocclusion-de-classe-ii-asym%C3%A3-trique%C3%A2-une-%C3%A3-tude-de-cas
#15
Antonio Manni, Daniela Lupini, Mauro Cozzani
No abstract text is available yet for this article.
April 4, 2017: International Orthodontics
https://www.readbyqxmd.com/read/28389179/bone-anchored-intermaxillary-elastics-in-an-asymmetric-class-ii-malocclusion-a-case-report
#16
Antonio Manni, Daniela Lupini, Mauro Cozzani
PURPOSE: A 13-year-old male patient, presenting a Class II, division 1 malocclusion and crowding was treated by an innovative technique. METHODS: After rapid palatal expansion by a Hyrax appliance, the teeth were bonded with straightwire brackets. Two miniscrews were inserted, one per side, in the mandibular buccal bone between the roots of the mandibular first molar and the second premolar. On the right side, the miniscrew implant was connected to the hook clamped on a 0...
April 4, 2017: International Orthodontics
https://www.readbyqxmd.com/read/28387361/origin-and-spread-of-human-mitochondrial-dna-haplogroup-u7
#17
Hovhannes Sahakyan, Baharak Hooshiar Kashani, Rakesh Tamang, Alena Kushniarevich, Amirtharaj Francis, Marta D Costa, Ajai Kumar Pathak, Zaruhi Khachatryan, Indu Sharma, Mannis van Oven, Jüri Parik, Hrant Hovhannisyan, Ene Metspalu, Erwan Pennarun, Monika Karmin, Erika Tamm, Kristiina Tambets, Ardeshir Bahmanimehr, Tuuli Reisberg, Maere Reidla, Alessandro Achilli, Anna Olivieri, Francesca Gandini, Ugo A Perego, Nadia Al-Zahery, Massoud Houshmand, Mohammad Hossein Sanati, Pedro Soares, Ekta Rai, Jelena Šarac, Tena Šarić, Varun Sharma, Luisa Pereira, Veronica Fernandes, Viktor Černý, Shirin Farjadian, Deepankar Pratap Singh, Hülya Azakli, Duran Üstek, Natalia Ekomasova Trofimova, Ildus Kutuev, Sergei Litvinov, Marina Bermisheva, Elza K Khusnutdinova, Niraj Rai, Manvendra Singh, Vijay Kumar Singh, Alla G Reddy, Helle-Viivi Tolk, Svjetlana Cvjetan, Lovorka Barac Lauc, Pavao Rudan, Emmanuel N Michalodimitrakis, Nicholas P Anagnou, Kalliopi I Pappa, Maria V Golubenko, Vladimir Orekhov, Svetlana A Borinskaya, Katrin Kaldma, Monica A Schauer, Maya Simionescu, Vladislava Gusar, Elena Grechanina, Periyasamy Govindaraj, Mikhail Voevoda, Larissa Damba, Swarkar Sharma, Lalji Singh, Ornella Semino, Doron M Behar, Levon Yepiskoposyan, Martin B Richards, Mait Metspalu, Toomas Kivisild, Kumarasamy Thangaraj, Phillip Endicott, Gyaneshwer Chaubey, Antonio Torroni, Richard Villems
Human mitochondrial DNA haplogroup U is among the initial maternal founders in Southwest Asia and Europe and one that best indicates matrilineal genetic continuity between late Pleistocene hunter-gatherer groups and present-day populations of Europe. While most haplogroup U subclades are older than 30 thousand years, the comparatively recent coalescence time of the extant variation of haplogroup U7 (~16-19 thousand years ago) suggests that its current distribution is the consequence of more recent dispersal events, despite its wide geographical range across Europe, the Near East and South Asia...
April 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28380461/are-pretreatment-neutrophil-lymphocyte-ratio-and-platelet-lymphocyte-ratio-useful-in-predicting-the-outcomes-of-patients-with-small-cell-lung-cancer
#18
Min Deng, Xuelei Ma, Xiao Liang, Chenjing Zhu, Manni Wang
OBJECTIVES: The neutrophil-lymphocyte ratio (NLR) and the platelet-lymphocyte ratio (PLR) have been proved to affect the prognosis of various types of cancers. However, the prognostic role of NLR and PLR in patients with small-cell lung cancer (SCLC) remains controversial. The objective of this study is to assess the prognostic values of NLR, PLR and other potential prognostic indexes in SCLC patients. RESULTS: The optimal cutoff levels were 2.65 for NLR, 125 for PLR and 210 for LDH by ROC curves analysis...
June 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/28333205/convergence-of-domain-architecture-structure-and-ligand-affinity-in-animal-and-plant-rna-binding-proteins
#19
Raquel Dias, Austin Manny, Oralia Kolaczkowski, Bryan Kolaczkowski
Reconstruction of ancestral protein sequences using phylogenetic methods is a powerful technique for directly examining the evolution of molecular function. Although ancestral sequence reconstruction (ASR) is itself very efficient, downstream functional, and structural studies necessary to characterize when and how changes in molecular function occurred are often costly and time-consuming, currently limiting ASR studies to examining a relatively small number of discrete functional shifts. As a result, we have very little direct information about how molecular function evolves across large protein families...
June 1, 2017: Molecular Biology and Evolution
https://www.readbyqxmd.com/read/28291868/the-response-ac-a-ratio-before-and-after-the-onset-of-myopia
#20
Donald O Mutti, G Lynn Mitchell, Lisa A Jones-Jordan, Susan A Cotter, Robert N Kleinstein, Ruth E Manny, J Daniel Twelker, Karla Zadnik
Purpose: To investigate the ratio of accommodative convergence per diopter of accommodative response (AC/A ratio) before, during, and after myopia onset. Methods: Subjects were 698 children aged 6 to 14 years who became myopic and 430 emmetropic children participating in the Collaborative Longitudinal Evaluation of Ethnicity and Refractive Error. Refractive error was measured using cycloplegic autorefraction, near work by parent survey, and the AC/A ratio by simultaneously monitoring convergence and accommodative response...
March 1, 2017: Investigative Ophthalmology & Visual Science
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