keyword
https://read.qxmd.com/read/38545110/case-report-long-term-follow-up-of-patients-who-received-a-fimch-vaccine-for-prevention-of-recurrent-urinary-tract-infections-caused-by-antibiotic-resistant-enterobacteriaceae-a-case-report-series
#1
Elise Perer, Helen Stacey, Terri Eichorn, Heidi Hughey, Julie Lawrence, Eric Cunningham, Mark O'Neil Johnson, Kevin Bacon, Andrew Kau, Scott J Hultgren, Thomas M Hooton, Jennifer L Harris
Urinary tract infections (UTI) caused by carbapenem-resistant Enterobacteriaceae (CRE) are considered one of the most urgent health threats to humans according to the Centers for Disease Control (CDC), and the World Health Organization (WHO). A FimCH Vaccine expanded access study is being conducted in patients with a history of antibiotic resistant UTIs who are considered to be at risk for development of CRE UTI. This case series describes the clinical, safety and immunogenicity findings for four participants who received a FimCH four-vaccine series...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38534937/the-rethinking-clinical-trials-program-retreat-2023-creating-partnerships-to-optimize-quality-cancer-care
#2
Ana-Alicia Beltran-Bless, Mark Clemons, Lisa Vandermeer, Khaled El Emam, Terry L Ng, Sharon McGee, Arif Ali Awan, Gregory Pond, Julie Renaud, Gwen Barton, Brian Hutton, Marie-France Savard
Patients, families, healthcare providers and funders face multiple comparable treatment options without knowing which provides the best quality of care. As a step towards improving this, the REthinking Clinical Trials (REaCT) pragmatic trials program started in 2014 to break down many of the traditional barriers to performing clinical trials. However, until other innovative methodologies become widely used, the impact of this program will remain limited. These innovations include the incorporation of near equivalence analyses and the incorporation of artificial intelligence (AI) into clinical trial design...
March 6, 2024: Current Oncology
https://read.qxmd.com/read/38532734/utility-of-focused-cardiac-ultrasonography-training-in-veterinary-students-to-differentiate-stages-of-subclinical-myxomatous-mitral-valve-disease-in-dogs
#3
JOURNAL ARTICLE
Terry Huh, Erin J Achilles, Laura K Massey, Kerry A Loughran, Éva Larouche-Lebel, Victoria Convey, Victoria F McKaba, Alexandra Crooks, Marc S Kraus, Anna R Gelzer, Mark A Oyama
BACKGROUND: Differentiation of the subclinical phases of myxomatous mitral valve disease (MMVD) in dogs relies heavily on echocardiography. Focused cardiac ultrasonography (FCU) is a point-of-care technique that can assess heart size. HYPOTHESIS/OBJECTIVES: Veterinary students trained in FCU can differentiate dogs with subclinical MMVD based on left ventricular (LV) and left atrial (LA) dimensions. ANIMALS: Forty-eight dogs with subclinical MMVD...
March 27, 2024: Journal of Veterinary Internal Medicine
https://read.qxmd.com/read/38530249/household-transmission-dynamics-of-asymptomatic-sars-cov-2-infected-children-a-multinational-controlled-case-ascertained-prospective-study
#4
JOURNAL ARTICLE
Anna Funk, Todd A Florin, Nathan Kuppermann, Yaron Finkelstein, Alissa Kazakoff, Michael Baldovsky, Daniel J Tancredi, Kristen Breslin, Kelly R Bergmann, Michael Gardiner, Christopher M Pruitt, Deborah R Liu, Mark I Neuman, Matthew Wilkinson, Lilliam Ambroggio, Xiao-Li Pang, Simon Cauchemez, Richard Malley, Terry P Klassen, Bonita E Lee, Daniel C Payne, Salaheddin M Mahmud, Stephen B Freedman
BACKGROUND: Asymptomatic SARS-CoV-2 infection in children is highly prevalent but its acute and chronic implications have been minimally described. METHODS: In this controlled case-ascertained household transmission study, we recruited asymptomatic children <18 years with SARS-CoV-2 nucleic acid testing performed at 12 tertiary care pediatric institutions in Canada and the United States. We attempted to recruit all test-positive children and 1 to 3 test-negative, site-matched controls...
March 26, 2024: Clinical Infectious Diseases
https://read.qxmd.com/read/38520396/liquid-structure-of-ionic-liquids-with-ntf-2-anions-derived-from-neutron-scattering
#5
JOURNAL ARTICLE
Anne McGrogan, Jack Lafferty, Lauren O'Neill, Lucy Brown, J Mark Young, Peter Goodrich, Mark J Muldoon, Leila Moura, Sarah Youngs, Terri-Louise Hughes, Sabrina Gärtner, Tristan G A Youngs, John D Holbrey, Małgorzata Swadźba-Kwaśny
The liquid structure of three common ionic liquids (ILs) was investigated by neutron scattering for the first time. The ILs were based on the bis(trifluoromethanesulfonyl)imide anion, abbreviated in the literature as [NTf2 ]- or [TFSI]- , and on the following cations: 1-ethyl-3-methylimidazolium, [C2 mim]+ ; 1-decyl-3-methylimidazolium, [C10 mim]+ ; and trihexyl(tetradecyl)phosphonium, [P666,14 ]+ . Comparative analysis of the three ILs confirmed increased size of nonpolar nanodomains with increasing bulk of alkyl chains...
March 23, 2024: Journal of Physical Chemistry. B
https://read.qxmd.com/read/38511222/sparsentan-ameliorates-glomerular-hypercellularity-and-inflammatory-gene-networks-induced-by-iga1-igg-immune-complexes-in-a-mouse-model-of-iga-nephropathy
#6
JOURNAL ARTICLE
Colin Reily, Zina Moldoveanu, Tiziano Pramparo, Stacy Hall, Zhi-Qiang Huang, Terri Rice, Lea Novak, Radko Komers, Celia P Jenkinson, Jan Novak
IgA nephropathy (IgAN), is characterized by glomerular deposition of immune complexes (IC) consisting of IgA1 with O -glycans deficient in galactose (Gd-IgA1) and Gd-IgA1-specific IgG autoantibodies. These ICs induce kidney injury, and in the absence of disease-specific therapy, up to 40% of IgAN patients progress to kidney failure. IgA1 with its clustered O -glycans is unique to humans, which hampered development of small-animal models of IgAN. Here, we used a model wherein engineered IC (EIC) formed from human Gd-IgA1 and recombinant human IgG autoantibody are injected into nude mice to induce glomerular injury mimicking human IgAN...
March 21, 2024: American Journal of Physiology. Renal Physiology
https://read.qxmd.com/read/38504141/breast-and-bowel-cancers-diagnosed-in-people-too-young-to-have-cancer-a-blueprint-for-research-using-family-and-twin-studies
#7
JOURNAL ARTICLE
John L Hopper, Shuai Li, Robert J MacInnis, James G Dowty, Tuong L Nguyen, Minh Bui, Gillian S Dite, Vivienne F C Esser, Zhoufeng Ye, Enes Makalic, Daniel F Schmidt, Benjamin Goudey, Karen Alpen, Miroslaw Kapuscinski, Aung Ko Win, Pierre-Antoine Dugué, Roger L Milne, Harindra Jayasekara, Jennifer D Brooks, Sue Malta, Lucas Calais-Ferreira, Alexander C Campbell, Jesse T Young, Tu Nguyen-Dumont, Joohon Sung, Graham G Giles, Daniel Buchanan, Ingrid Winship, Mary Beth Terry, Melissa C Southey, Mark A Jenkins
Young breast and bowel cancers (e.g., those diagnosed before age 40 or 50 years) have far greater morbidity and mortality in terms of years of life lost, and are increasing in incidence, but have been less studied. For breast and bowel cancers, the familial relative risks, and therefore the familial variances in age-specific log(incidence), are much greater at younger ages, but little of these familial variances has been explained. Studies of families and twins can address questions not easily answered by studies of unrelated individuals alone...
March 19, 2024: Genetic Epidemiology
https://read.qxmd.com/read/38496424/large-scale-genome-wide-association-study-of-398-238-women-unveils-seven-novel-loci-associated-with-high-grade-serous-epithelial-ovarian-cancer-risk
#8
Daniel R Barnes, Jonathan P Tyrer, Joe Dennis, Goska Leslie, Manjeet K Bolla, Michael Lush, Amber M Aeilts, Kristiina Aittomäki, Nadine Andrieu, Irene L Andrulis, Hoda Anton-Culver, Adalgeir Arason, Banu K Arun, Judith Balmaña, Elisa V Bandera, Rosa B Barkardottir, Lieke P V Berger, Amy Berrington de Gonzalez, Pascaline Berthet, Katarzyna Białkowska, Line Bjørge, Amie M Blanco, Marinus J Blok, Kristie A Bobolis, Natalia V Bogdanova, James D Brenton, Henriett Butz, Saundra S Buys, Maria A Caligo, Ian Campbell, Carmen Castillo, Kathleen B M Claes, Sarah V Colonna, Linda S Cook, Mary B Daly, Agnieszka Dansonka-Mieszkowska, Miguel de la Hoya, Anna deFazio, Allison DePersia, Yuan Chun Ding, Susan M Domchek, Thilo Dörk, Zakaria Einbeigi, Christoph Engel, D Gareth Evans, Lenka Foretova, Renée T Fortner, Florentia Fostira, Maria Cristina Foti, Eitan Friedman, Megan N Frone, Patricia A Ganz, Aleksandra Gentry-Maharaj, Gord Glendon, Andrew K Godwin, Anna González-Neira, Mark H Greene, Jacek Gronwald, Aliana Guerrieri-Gonzaga, Ute Hamann, Thomas V O Hansen, Holly R Harris, Jan Hauke, Florian Heitz, Frans B L Hogervorst, Maartje J Hooning, John L Hopper, Chad D Huff, David G Huntsman, Evgeny N Imyanitov, Louise Izatt, Anna Jakubowska, Paul A James, Ramunas Janavicius, Esther M John, Siddhartha Kar, Beth Y Karlan, Catherine J Kennedy, Lambertus A L M Kiemeney, Irene Konstantopoulou, Jolanta Kupryjanczyk, Yael Laitman, Ofer Lavie, Kate Lawrenson, Jenny Lester, Fabienne Lesueur, Carlos Lopez-Pleguezuelos, Phuong L Mai, Siranoush Manoukian, Taymaa May, Iain A McNeish, Usha Menon, Roger L Milne, Francesmary Modugno, Jennifer M Mongiovi, Marco Montagna, Kirsten B Moysich, Susan L Neuhausen, Finn C Nielsen, Catherine Noguès, Edit Oláh, Olufunmilayo I Olopade, Ana Osorio, Laura Papi, Harsh Pathak, Celeste L Pearce, Inge S Pedersen, Ana Peixoto, Tanja Pejovic, Pei-Chen Peng, Beth N Peshkin, Paolo Peterlongo, C Bethan Powell, Darya Prokofyeva, Miquel Angel Pujana, Paolo Radice, Muhammad U Rashid, Gad Rennert, George Richenberg, Dale P Sandler, Naoko Sasamoto, Veronica W Setiawan, Priyanka Sharma, Weiva Sieh, Christian F Singer, Katie Snape, Anna P Sokolenko, Penny Soucy, Melissa C Southey, Dominique Stoppa-Lyonnet, Rebecca Sutphen, Christian Sutter, Manuel R Teixeira, Kathryn L Terry, Liv Cecilie V Thomsen, Marc Tischkowitz, Amanda E Toland, Toon Van Gorp, Ana Vega, Digna R Velez Edwards, Penelope M Webb, Jeffrey N Weitzel, Nicolas Wentzensen, Alice S Whittemore, Stacey J Winham, Anna H Wu, Siddhartha Yadav, Yao Yu, Argyrios Ziogas, Andrew Berchuck, Fergus J Couch, Ellen L Goode, Marc T Goodman, Alvaro N Monteiro, Kenneth Offit, Susan J Ramus, Harvey A Risch, Joellen M Schildkraut, Mads Thomassen, Jacques Simard, Douglas F Easton, Michelle R Jones, Georgia Chenevix-Trench, Simon A Gayther, Antonis C Antoniou, Paul D P Pharoah
BACKGROUND: Nineteen genomic regions have been associated with high-grade serous ovarian cancer (HGSOC). We used data from the Ovarian Cancer Association Consortium (OCAC), Consortium of Investigators of Modifiers of BRCA1/BRCA2 (CIMBA), UK Biobank (UKBB), and FinnGen to identify novel HGSOC susceptibility loci and develop polygenic scores (PGS). METHODS: We analyzed >22 million variants for 398,238 women. Associations were assessed separately by consortium and meta-analysed...
March 4, 2024: medRxiv
https://read.qxmd.com/read/38494593/understanding-rural-pharmacists-perspectives-lived-experiences-and-insights-associated-with-rural-recruitment-and-retention
#9
JOURNAL ARTICLE
Daniel R Terry, Blake Peck, Hoang Phan, Danny Hills, Jaclyn Bishop, Mark Kirschbaum, Kehinde O Obamiro, Ed Baker, David Schmitz
INTRODUCTION: Pharmacists serve an important role in rural communities, and in some cases they may be the only health professional available. Their recruitment and retention is a major concern for rural communities and health services; however, a deeper understanding regarding the advantages and challenges of sustaining a rural pharmacy workforce is somewhat limited. The aim of this study was to develop a deeper understanding of pharmacists' perspectives about factors influencing pharmacist recruitment and retention to rural and remote communities...
March 2024: Rural and Remote Health
https://read.qxmd.com/read/38483264/conservation-energetics-of-beluga-whales-using-resting-and-swimming-metabolism-to-understand-threats-to-an-endangered-population
#10
JOURNAL ARTICLE
Jason S John, Dennis R Christen, Katherine L Flammer, Traci L Kendall, Emily C Nazario, Beau P Richter, Verena Gill, Terrie M Williams
The balance between energetic costs and acquisition in free-ranging species is essential for survival, and provides important insights regarding the physiological impact of anthropogenic disturbances on wild animals. For marine mammals such as beluga whales (Delphinapterus leucas), the first step in modeling this bioenergetic balance requires an examination of resting and active metabolic demands. Here, we used open-flow respirometry to measure oxygen consumption during surface rest and submerged swimming by trained beluga whales, and compared these measurements with those of a commonly studied odontocete, the Atlantic bottlenose dolphin (Tursiops truncatus)...
March 1, 2024: Journal of Experimental Biology
https://read.qxmd.com/read/38482655/relational-work-is-the-work-virtual-healthcare-transformation-for-rural-remote-and-first-nations-communities-in-british-columbia
#11
JOURNAL ARTICLE
John Mah, John Pawlovich, Terri Aldred, Scott Graham, Ray Markham, Kim Williams, Bob Woollard, John Grogan, Dee Taylor, Nelly D Oelke, Alison James, Melissa Stewart, Sonya Cressman, Arianna Hogan, Daniel Harper
The healthcare crisis across unceded First Nations' territories in rural, remote and Indigenous communities in British Columbia (BC) is marked by persistent barriers to accessing care and support close to home. This commentary describes an exceptional story of how technology, trusted partnerships and relationships came together to create an innovative suite of virtual care programs called "Real-Time Virtual Support" (RTVS). We describe key approaches, learnings and future considerations to improve the equity of healthcare delivery for rural, remote and First Nations communities...
January 2024: HealthcarePapers
https://read.qxmd.com/read/38464063/the-updated-mouse-universal-genotyping-array-bioinformatic-pipeline-improves-genetic-qc-in-laboratory-mice
#12
Matthew W Blanchard, John Sebastian Sigmon, Jennifer Brennan, Chidima Ahulamibe, Michelle E Allen, Ralph S Baric, Timothy A Bell, Joeseph Farrington, Dominic Ciavatta, Marta Cruz Cisneros, Madison Drushal, Martin T Ferris, Rebecca Fry, Christiann Gaines, Bin Gu, Mark T Heise, Richard Austin Hodges, Tal Kafri, Rachel Lynch, Terry Magnuson, Darla Miller, Caroline E Y Murphy, David Truong Nguyen, Kelsey E Noll, Megan Proulx, Chris Sassetti, Ginger D Shaw, Jeremy M Simon, Clare Smith, Myrek Styblo, Lisa Tarantino, Joyce Woo, Fernando Pardo Manuel de Villena
The MiniMUGA genotyping array is a popular tool for genetic QC of laboratory mice and genotyping of samples from most types of experimental crosses involving laboratory strains, particularly for reduced complexity crosses. The content of the production version of the MiniMUGA array is fixed; however, there is the opportunity to improve array's performance and the associated report's usefulness by leveraging thousands of samples genotyped since the initial description of MiniMUGA in 2020. Here we report our efforts to update and improve marker annotation, increase the number and the reliability of the consensus genotypes for inbred strains and increase the number of constructs that can reliably be detected with MiniMUGA...
March 3, 2024: bioRxiv
https://read.qxmd.com/read/38452116/structure-activity-relationships-of-natural-and-semisynthetic-plecomacrolides-suggest-distinct-pathways-for-hiv-1-immune-evasion-and-vacuolar-atpase-dependent-lysosomal-acidification
#13
JOURNAL ARTICLE
Morgan McCauley, Matthew Huston, Alanna R Condren, Filipa Pereira, Joel Cline, Marianne Yaple-Maresh, Mark M Painter, Gretchen E Zimmerman, Andrew W Robertson, Nolan Carney, Christopher Goodall, Valeri Terry, Rolf Müller, David H Sherman, Kathleen L Collins
The human immunodeficiency virus (HIV)-encoded accessory protein Nef enhances pathogenicity by reducing major histocompatibility complex I (MHC-I) cell surface expression, protecting HIV-infected cells from immune recognition. Nef-dependent downmodulation of MHC-I can be reversed by subnanomolar concentrations of concanamycin A ( 1 ), a well-known inhibitor of vacuolar ATPase, at concentrations below those that interfere with lysosomal acidification or degradation. We conducted a structure-activity relationship study that assessed 76 compounds for Nef inhibition, 24 and 72 h viability, and lysosomal neutralization in Nef-expressing primary T cells...
March 7, 2024: Journal of Medicinal Chemistry
https://read.qxmd.com/read/38448198/can-critical-care-transport-be-safely-reduced-in-children-intubated-during-emergency-management-of-status-epilepticus-in-the-united-kingdom-a-national-audit-with-case-control-analysis
#14
JOURNAL ARTICLE
Philip Knight, Victoria Norman, Rochelle Gully, Dora Wood, Dusan Raffaj, Laura Riddick, Stephen Hancock, Sanjay Revanna, Mohammed Uvaise, Sasha Herring, Mark Worrall, Ashley Daye, Mark Terris, Cormac O'Brien, Ananth Kumar, Sophie Scott, Lisa Pritchard, Srinivasan Palaniappan, Charlotte Hughes, Michael J Griksaitis, Shelley Riphagen, Padmanabhan Ramnarayan
OBJECTIVE: This study describes the baseline clinical characteristics, predictors of successful extubation at referring hospitals and short-term outcomes of children intubated for status epilepticus and referred to United Kingdom (UK) paediatric critical care transport teams (PCCTs). DESIGN: Multicentre audit with case-control analysis, conducted between 1 September 2018 and 1 September 2020. SETTING: This study involved 10 UK PCCTs. PATIENTS: Children over 1 month of age intubated during emergency management for status epilepticus (SE), referred to UK PCCTs...
March 6, 2024: Archives of Disease in Childhood
https://read.qxmd.com/read/38427131/virtual-multi-institutional-tumor-board-a-strategy-for-personalized-diagnoses-and-management-of-rare-cns-tumors
#15
JOURNAL ARTICLE
James L Rogers, Thomas Wall, Alvina A Acquaye-Mallory, Lisa Boris, Yeonju Kim, Kenneth Aldape, Martha M Quezado, John A Butman, James G Smirniotopoulos, Huma Chaudhry, Christina I Tsien, Prashant Chittiboina, Kareem Zaghloul, Orwa Aboud, Nicholas G Avgeropoulos, Eric C Burton, David M Cachia, Karan S Dixit, Jan Drappatz, Erin M Dunbar, Peter Forsyth, Edina Komlodi-Pasztor, Jacob Mandel, Byram H Ozer, Eudocia Q Lee, Surabhi Ranjan, Rimas V Lukas, Margarita Raygada, Michael E Salacz, Matthew A Smith-Cohn, James Snyder, Ariane Soldatos, Brett J Theeler, Brigitte C Widemann, Kevin A Camphausen, John D Heiss, Terri S Armstrong, Mark R Gilbert, Marta Penas-Prado
PURPOSE: Multidisciplinary tumor boards (MTBs) integrate clinical, molecular, and radiological information and facilitate coordination of neuro-oncology care. During the COVID-19 pandemic, our MTB transitioned to a virtual and multi-institutional format. We hypothesized that this expansion would allow expert review of challenging neuro-oncology cases and contribute to the care of patients with limited access to specialized centers. METHODS: We retrospectively reviewed records from virtual MTBs held between 04/2020-03/2021...
March 1, 2024: Journal of Neuro-oncology
https://read.qxmd.com/read/38420614/long-term-survivors-of-glioblastoma-tumor-molecular-clinical-and-imaging-findings
#16
JOURNAL ARTICLE
Nicole Briceno, Elizabeth Vera, Edina Komlodi-Pasztor, Zied Abdullaev, Anna Choi, Ewa Grajkowska, Tricia Kunst, Jason Levine, Matthew Lindsley, Kelly Fernandez, Jennifer Reyes, Lisa Boris, Eric Burton, Marissa Panzer, Lily Polskin, Marta Penas-Prado, Tina Pillai, Brett J Theeler, Jing Wu, Kathleen Wall, Antonios Papanicolau-Sengos, Martha Quezado, James Smirniotopoulos, Kenneth Aldape, Terri S Armstrong, Mark R Gilbert
BACKGROUND: Glioblastoma (GBM) is the most aggressive primary brain malignancy with <45% living a year beyond diagnosis. Previously published investigations of long-term survivors (LTS) provided clinical data but rarely incorporated a comprehensive clinical and molecular analysis. Herein, we identify clinical, imaging, molecular, and outcome features for 23 GBM-LTS patients and compare them with a matched cohort of short-term survivors (STS). METHODS: Molecularly confirmed Isocitrate Dehydrogenase (IDH) wildtype GBM patients living ≥3 years post-diagnosis ( N LTS  = 23) or <3 years ( N STS  = 75) were identified from our Natural History study...
2024: Neuro-oncology advances
https://read.qxmd.com/read/38419392/clinical-trials-studying-suicide-risk-reduction-who-is-excluded-from-participation
#17
JOURNAL ARTICLE
Ryan E Lawrence, Chaya Jaffe, Yinjun Zhao, Yuanjia Wang, Terry E Goldberg
OBJECTIVE: The use of exclusion criteria in clinical trials can cause research participants to differ markedly from clinical populations, which negatively impacts generalizability of results. This study identifies and quantifies common and recurring exclusion criteria in clinical trials studying suicide risk reduction, and estimates their impact on eligibility among a clinical sample of adults in an emergency department with high suicide risk. METHOD: Recent trials were identified by searching PubMed (terms suicide, efficacy, effectiveness, limited to clinical trials in prior 5 years)...
February 28, 2024: Archives of Suicide Research: Official Journal of the International Academy for Suicide Research
https://read.qxmd.com/read/38414290/social-connections-and-social-identity-as-a-basis-for-learning-and-support-experiences-of-medical-students-with-minoritised-and-non-minoritised-ethnic-identities
#18
JOURNAL ARTICLE
Stephanie Bull, Rohini Terry, Neil Rice, Daniele Carrieri, Mark Tarrant, Gerens Curnow
BACKGROUND: Social connections between medical students provide a key basis for learning and support. These connections, and associated social identity, may be patterned by ethnicity, and students often perform similarly academically to those they connect with. The mechanisms that underpin the formation of these connections and the role that they play are not fully understood. This study explored how medical students connect with each other, and the potential impact of this on their academic attainment and well-being, with a focus on students with minoritised ethnic identities...
February 27, 2024: Medical Education
https://read.qxmd.com/read/38391389/features-associated-with-radiographic-pneumonia-in-children-with-sars-cov-2
#19
JOURNAL ARTICLE
Todd A Florin, Stephen B Freedman, Jianling Xie, Anna L Funk, Daniel J Tancredi, Kelly Kim, Mark I Neuman, Adriana Yock-Corrales, Kelly R Bergmann, Kristen A Breslin, Yaron Finkelstein, Fahd A Ahmad, Usha R Avva, Maren M Lunoe, Pradip P Chaudhari, Nipam P Shah, Amy C Plint, Vikram J Sabhaney, Usha Sethuraman, Michael A Gardiner, Laura F Sartori, Bruce Wright, Nidhya Navanandan, Santiago Mintegi, Iker Gangoiti, Meredith L Borland, Shu-Ling Chong, Maria Y Kwok, Michelle Eckerle, Naveen Poonai, Carlos Miguel Angelats Romero, Muhammad Waseem, Jasmine R Nebhrajani, Maala Bhatt, Kerry Caperell, Carmen Campos, Sarah M Becker, Claudia R Morris, Alexander J Rogers, April J Kam, Viviana Pavlicich, Laura Palumbo, Stuart R Dalziel, Andrea K Morrison, Pedro B Rino, Jonathan C Cherry, Marina I Salvadori, Lilliam Ambroggio, Terry P Klassen, Daniel C Payne, Richard Malley, Norma-Jean Simon, Nathan Kuppermann
No abstract text is available yet for this article.
February 23, 2024: Journal of the Pediatric Infectious Diseases Society
https://read.qxmd.com/read/38355340/management-strategies-and-prognosis-of-patients-ineligible-for-transcatheter-mitral-valve-replacement
#20
JOURNAL ARTICLE
Syeda A Hasan, Moustafa Morsi, Belinda S Frakes, Marien E Bryson, Christian W Schmidt, Puvi Seshiah, Joseph Choo, J Michael Smith, Geoffrey A Answini, Terri L Stewart-Dehner, Senan J Yasar, James G Jollis, Mark D Berlacher, Teresa M Ratajczak, Eugene S Chung, Dean J Kereiakes, Santiago Garcia
BACKGROUND: Transcatheter mitral valve replacement (TMVR) faces anatomical challenges, currently limiting widespread adoption. OBJECTIVES: To describe the natural history and prognosis of patients ineligible for various TMVR devices. METHODS: During a 4-year period (2019-2023) 3 TMVR devices (SAPIEN M3, Intrepid and Alta Valve) became available at a single institution (The Christ Hospital, Cincinnati, OH) in the setting of pivotal clinical trials or early feasibility study...
February 10, 2024: Cardiovascular Revascularization Medicine: Including Molecular Interventions
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