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Osteochondral defect

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https://www.readbyqxmd.com/read/28087165/radiographic-comparison-of-adolescent-athletes-with-elbow-osteochondritis-dissecans-to-ulnar-collateral-ligament-injuries-and-controls
#1
Brian C Lau, Nirav K Pandya
BACKGROUND: There are excellent data supporting recommendations to prevent elbow injuries (osteochondritis dissecans [OCD] and ulnar collateral ligament [UCL] injuries), such as pitch count and pitch type in baseball, but anatomic risk factors have not been thoroughly examined. This study aimed to evaluate radiographic measurements in adolescents with elbow OCD lesions or UCL injuries and controls. METHODS: We retrospectively identified adolescent patients between 2011 and 2016 with isolated capitellum OCD, UCL tear, or normal elbows based on magnetic resonance imaging...
January 10, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28054960/evaluation-of-magnetic-nanoparticle-labeled-chondrocytes-cultivated-on-a-type-ii-collagen-chitosan-poly-lactic-co-glycolic-acid-biphasic-scaffold
#2
Juin-Yih Su, Shi-Hui Chen, Yu-Pin Chen, Wei-Chuan Chen
Chondral or osteochondral defects are still controversial problems in orthopedics. Here, chondrocytes labeled with magnetic nanoparticles were cultivated on a biphasic, type II collagen-chitosan/poly(lactic-co-glycolic acid) scaffold in an attempt to develop cultures with trackable cells exhibiting growth, differentiation, and regeneration. Rabbit chondrocytes were labeled with magnetic nanoparticles and characterized by scanning electron microscopy (SEM), transmission electron (TEM) microscopy, and gene and protein expression analyses...
January 4, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28041611/the-mechanics-of-focal-chondral-defects-in-the-hip
#3
Brenden J Klennert, Benjamin J Ellis, Travis G Maak, Ashley L Kapron, Jeffrey A Weiss
There is a mean incidence of osteoarthritis (OA) of the hip in 8% of the overall population. In the presence of focal chondral defects, defined as localized damage to the articular cartilage, there is an increased risk of symptomatic progression toward OA. This relationship between chondral defects and subsequent development of OA has led to substantial efforts to develop effective procedures for surgical cartilage repair. This study examined the effects of chondral defects and labral delamination on cartilage mechanics in the dysplastic hip during the gait cycle using subject-specific finite element analysis...
November 29, 2016: Journal of Biomechanics
https://www.readbyqxmd.com/read/28040880/autologous-osteochondral-transplantation-mosaicplasty-in-articular-cartilage-defects-of-the-patellofemoral-joint-retrospective-analysis-of-33-cases
#4
T Y Emre, Z Atbasi, D T Demircioglu, M Uzun, O Kose
OBJECTIVE: The purpose of this retrospective study was to evaluate the results of osteochondral autografting (mosaicplasty) in isolated articular cartilage defects of the patellofemoral joint. MATERIALS AND METHODS: Thirty-three patients who underwent mosaicplasty for patellofemoral (either patella or trochlea) cartilage defects (modified Outerbridge classification: grades III and IV) of the knee joint were retrospectively reviewed. There were 25 male and 8 female patients with a mean age of 31...
December 31, 2016: Musculoskeletal Surgery
https://www.readbyqxmd.com/read/28040083/a-novel-aragonite-based-scaffold-for-osteochondral-regeneration-early-experience-on-human-implants-and-technical-developments
#5
Elizaveta Kon, Dror Robinson, Peter Verdonk, Matej Drobnic, Jenel Mariano Patrascu, Oliver Dulic, Gordon Gavrilovic, Giuseppe Filardo
INTRODUCTION: Chondral and osteochondral lesions represent a debilitating disease. Untreated lesions remain a risk factor for more extensive joint damage. The objective of this clinical study is to evaluate safety and early results of an aragonite-based scaffold used for osteochondral unit repair, by analysing both clinical outcome and MRI results, as well as the benefits of the procedure optimization through novel tapered shaped implants. METHODS: A crystalline aragonite bi-phasic scaffold was implanted in patients affected by focal chondral-osteochondral knee lesions of the condyle and trochlea...
December 2016: Injury
https://www.readbyqxmd.com/read/28039188/abnormal-joint-and-bone-wound-healing-in-hemophilia-mice-is-improved-by-extending-factor-ix-activity-after-hemarthrosis
#6
Junjiang Sun, Baolai Hua, Eric W Livingston, Sarah Taves, Peter B Johansen, Maureane Hoffman, Mirella Ezban, Dougald M Monroe, Ted A Bateman, Paul E Monahan
Wound healing requires interactions between coagulation, inflammation, angiogenesis, cellular migration, and proliferation. Healing in dermal wounds of hemophilia B mice is delayed when compared to hemostatically normal wild type (WT) mice, with abnormal persistence of iron deposition, inflammation, and neovascularity. We observed healing following induced joint hemorrhage in WT and factor IX (FIX) knockout (FIX(-/-)) mice, examining also parameters previously studied in an excisional skin wound model. Hemostatically normal mice tolerated this joint bleeding challenge, cleared blood from the joint, and healed with minimal pathology, even if additional autologous blood was injected intra-articularly at the time of wounding...
December 30, 2016: Blood
https://www.readbyqxmd.com/read/28024231/fabrication-of-injectable-high-strength-hydrogel-based-on-4-arm-star-peg-for-cartilage-tissue-engineering
#7
Jianqi Wang, Fengjie Zhang, Wing Pui Tsang, Chao Wan, Chi Wu
Hydrogels prepared from poly(ethylene glycol) (PEG) are widely applied in tissue engineering, especially those derived from a combination of functional multi-arm star PEG and linear crosslinker, with an expectation to form a structurally ideal network. However, the poor mechanical strength still renders their further applications. Here we examined the relationship between the dynamics of the pre-gel solution and the mechanical property of the resultant hydrogel in a system consisting of 4-arm star PEG functionalized with vinyl sulfone and short dithiol crosslinker...
December 20, 2016: Biomaterials
https://www.readbyqxmd.com/read/28002897/comparison-of-three-novel-biphasic-scaffolds-for-one-stage-treatment-of-osteochondral-defects-in-a-sheep-model
#8
F Gervaso, L Mangiavini, A Di Giancamillo, F Boschetti, D Izzo, D D Zani, M Di Giancamillo, I Tessaro, M Domenicucci, F Scalera, C Domeneghini, A M Crovace, A Sannino, G M Peretti
In the last years, several tissue engineering techniques have been applied to develop different kinds of osteochondral substitutes to overcome the scarce reparative properties of this tissue. The aim of this study was to generate and compare three biphasic scaffolds in an osteochondral lesion in a large-animal model. A critical osteochondral defect was generated in the medial femoral condyle of 18 skeletally mature sheep. Three defects were left untreated, the remaining lesions were divided into three groups: 5 lesions were treated with a biphasic scaffold made of collagen type I and small cylinders of Magnesium Hydroxyapatite; 5 lesions were treated with a biphasic substituted formed by collagen type I and Wollastonite, 5 lesions were treated with a scaffold made of collagen type I and small cylinders of Wollastonite/Hydroxyapatite...
October 2016: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/27994722/immediate-unrestricted-postoperative-weightbearing-and-mobilization-after-bone-marrow-stimulation-of-large-osteochondral-lesions-of-the-talus
#9
Gregory A Lundeen, Linda J Dunaway
OBJECTIVE: There remains no consensus on a postoperative protocol following arthroscopic treatment of osteochondral lesions of the talus (OLTs) and most studies report a period of immobilization and nonweightbearing. Outcomes are believed to decrease with larger size. The purpose of our study was to evaluate patients who underwent arthroscopic treatment of large (≥150 mm(2)) OLTs with immediate unrestricted weightbearing and mobilization postoperatively. DESIGN: Patients who underwent arthroscopic bone marrow stimulation for osteochondral defects were identified...
January 2017: Cartilage
https://www.readbyqxmd.com/read/27994721/particulated-juvenile-articular-cartilage-allograft-transplantation-for-osteochondral-talar-lesions
#10
Bryan M Saltzman, Johnny Lin, Simon Lee
OBJECTIVE: To report on our institution's early results from juvenile particulate cartilage allograft transplantation of the talus. DESIGN: Because of the relative rarity of the procedure at the talus, it was decided to provide a comprehensive understanding of the currently available evidence via a 2-part study with (1) a systematic review of the literature and (2) a retrospective single-center cohort study of the authors' patients, their demographics, and their early outcomes...
January 2017: Cartilage
https://www.readbyqxmd.com/read/27994717/evaluation-and-management-of-osteochondral-lesions-of-the-talus
#11
REVIEW
Christopher A Looze, Jason Capo, Michael K Ryan, John P Begly, Cary Chapman, David Swanson, Brian C Singh, Eric J Strauss
Osteochondral lesions of the talus are common injuries that affect a wide variety of active patients. The majority of these lesions are associated with ankle sprains and fractures though several nontraumatic etiologies have also been recognized. Patients normally present with a history of prior ankle injury and/or instability. In addition to standard ankle radiographs, magnetic resonance imaging and computed tomography are used to characterize the extent of the lesion and involvement of the subchondral bone...
January 2017: Cartilage
https://www.readbyqxmd.com/read/27919119/-osteochondritis-dissecans-of-the-talus-a-critical-review
#12
J Bruns, C R Habermann, J P Petersen
The etiology remains unclear. Mechanical factors seem to play an important role. Most histologies report clefts between the cartilage and bone and necrotic areas. Several classifications have been published based on observations from imaging techniques or on intraoperative findings. Clinical symptoms are unspecific. Imaging techniques are of great importance: X-rays of the ankle joint enable a quick diagnostic overview. MRT is the imaging-technique of choice for diagnosing OCDT-lesions. Regarding treatment, a tremendous number of retrospective publications exist...
April 2016: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/27912680/biomimetic-approaches-for-bone-tissue-engineering
#13
Johnathan Ng, Kara Spiller, Jonathan Bernhard, Gordana Vunjak-Novakovic
Although autologous bone grafts are considered a gold standard for the treatment of bone defects, they are limited by donor site morbidities and geometric requirements. Tissue engineering can overcome such limitations by creating fully viable biological bone grafts. We review here the use of native bone matrix, autologous mesenchymal cells and perfusion bioreactor systems as a tissue-engineering paradigm to grow bone in vitro. We also discuss emergent vascularization strategies to promote graft survival in vivo, and the role of inflammation in bone repair...
December 2, 2016: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/27910738/cartilage-repair-in-the-degenerative-ageing-knee
#14
Mats Brittberg, Andreas H Gomoll, José A Canseco, Jack Far, Martin Lind, James Hui
Background and purpose - Cartilage damage can develop due to trauma, resulting in focal chondral or osteochondral defects, or as more diffuse loss of cartilage in a generalized organ disease such as osteoarthritis. A loss of cartilage function and quality is also seen with increasing age. There is a spectrum of diseases ranging from focal cartilage defects with healthy surrounding cartilage to focal lesions in degenerative cartilage, to multiple and diffuse lesions in osteoarthritic cartilage. At the recent Aarhus Regenerative Orthopaedics Symposium (AROS) 2015, regenerative challenges in an ageing population were discussed by clinicians and basic scientists...
December 2, 2016: Acta Orthopaedica
https://www.readbyqxmd.com/read/27909662/osteochondral-autograft-transfer-technique-for-glenoid-osteochondral-defect
#15
Douglas J Wyland, Clint Beicker
Glenoid osteochondral defects can be a significant source of pain and disability in an active population. Many treatments are available, but most joint-preserving procedures are limited to debridement, abrasion chondroplasty, or marrow-stimulation techniques, all of which depend on healthy underlying bone and none of which address underlying bony pathology. Osteochondral autograft transfer has been a successful form of treatment for lesions in the knee, elbow, and ankle, especially when subchondral bone is involved...
October 2016: Arthroscopy Techniques
https://www.readbyqxmd.com/read/27906096/biological-and-functional-evaluation-of-a-novel-pyrolytic-carbon-implant-for-the-treatment-of-focal-osteochondral-defects-in-the-medial-femoral-condyle-assessment-in-a-canine-model
#16
Samantha L Salkeld, Laura P Patron, Joan C Lien, Stephen D Cook, Deryk G Jones
BACKGROUND: Osteochondral defects continue to be a clinical treatment challenge, and when left untreated, may cause pain and functional impairment. Pyrolytic carbon is a unique isotropic biomaterial used in heart valve and small joint replacements due to its excellent wear properties and biocompatibility with bone and articular cartilage. Therefore, a proposed solution is to utilize a focal pyrolytic carbon hemiarthroplasty implant as an alternative resurfacing treatment strategy for isolated cartilage lesions...
December 1, 2016: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/27893924/deciding-how-best-to-treat-cartilage-defects
#17
Lucy Oliver-Welsh, Justin W Griffin, Maximilian A Meyer, Matthew E Gitelis, Brian J Cole
The decision-making regarding and treatment of cartilage abnormalities requires a systematic approach. This article reviews the concepts and principles that guide the management of this complex problem. The precise incidence, demographics, and progression of cartilage lesions have not been clearly delineated. Pursuing a patient-centered approach that considers the available nonsurgical and surgical options remains the cornerstone of patient care. The importance of determining concomitant knee pathologies, the proper interpretation and implications of imaging findings, and an accurate determination of the intra-articular and subchondral findings represent the primary elements of the decision analysis...
November 1, 2016: Orthopedics
https://www.readbyqxmd.com/read/27891511/diagnostic-value-of-ct-arthrography-for-evaluation-of-osteochondral-lesions-at-the-ankle
#18
Jan S Kirschke, Sepp Braun, Thomas Baum, Christian Holwein, Christoph Schaeffeler, Andreas B Imhoff, Ernst J Rummeny, Klaus Woertler, Pia M Jungmann
Background. To retrospectively determine the diagnostic value of computed tomography arthrography (CTA) of the ankle in the evaluation of (osteo)chondral lesions in comparison to conventional magnetic resonance imaging (MRI) and intraoperative findings. Methods. A total of N = 79 patients had CTAs and MRI of the ankle; in 17/79 cases surgical reports with statements on cartilage integrity were available. Cartilage lesions and bony defects at talus and tibia were scored according to defect depth and size by two radiologists...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27826762/matrix-based-autologous-chondrocyte-implantation-in-children-and-adolescents-a-match-paired-analysis-in-a-follow-up-over-three-years-post-operation
#19
Thomas Richard Niethammer, Martin Holzgruber, Mehmet Fatih Gülecyüz, Patrick Weber, Matthias Frank Pietschmann, Peter Ernst Müller
PURPOSE: The aim of this study is the investigation of the clinical results after third generation autologous chondrocyte implantation in the knee in a follow-up over three years post-operation. Our primary focus is on the effects of this procedure on children and adolescent patients as there is a lack of knowledge regarding the clinical outcomes in children/adolescents in particular when compared with adults. METHODS: A total of 40 patients (43 defects) <20 years with cartilage defects of the knee were treated with third generation ACI (Novocart® 3D)...
November 8, 2016: International Orthopaedics
https://www.readbyqxmd.com/read/27824874/effect-of-transplanting-various-concentrations-of-a-composite-of-human-umbilical-cord-blood-derived-mesenchymal-stem-cells-and-hyaluronic-acid-hydrogel-on-articular-cartilage-repair-in-a-rabbit-model
#20
Yong-Beom Park, Chul-Won Ha, Jin-A Kim, Ji-Heon Rhim, Yong-Geun Park, Jun Young Chung, Han-Jun Lee
BACKGROUND: Mesenchymal stem cells (MSCs) are known to have therapeutic potential for cartilage repair. However, the optimal concentration of MSCs for cartilage repair remains unclear. Therefore, we aimed to explore the feasibility of cartilage repair by human umbilical cord blood-derived MSCs (hUCB-MSCs) and to determine the optimal concentrations of the MSCs in a rabbit model. METHODS: Osteochondral defects were created in the trochlear groove of femur in 55 rabbits...
2016: PloS One
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