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Osteochondral defect

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https://www.readbyqxmd.com/read/29140738/do-outcomes-of-osteochondral-allograft-transplantation-differ-based-on-age-and-sex-a-comparative-matched-group-analysis
#1
Rachel M Frank, Eric J Cotter, Simon Lee, Sarah Poland, Brian J Cole
BACKGROUND: The effect of patient age or sex on outcomes after osteochondral allograft transplantation (OCA) has not been assessed. PURPOSE: To determine clinical outcomes for male and female patients aged ≥40 years undergoing OCA compared with a group of patients aged <40 years. STUDY DESIGN: Cohort study; Level of evidence, 3. METHODS: A review of prospectively collected data of consecutive patients who underwent OCA by a single surgeon with a minimum follow-up of 2 years was conducted...
November 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29138892/-partial-and-complete-joint-transplantation-with-fresh-osteochondral-allografts-the-flocsat-concept
#2
REVIEW
C Krettek, J-D Clausen, N Bruns, C Neunaber
Cartilage defects in adult patients do not heal well. Fresh osteochondral allograft (OCA) transplantation is based on mature, living, mechanically sound hyaline cartilage attached to a bone interface, which is brought into an osteochondral defect, where it becomes osseointegrated. According to current knowledge, intact hyaline cartilage tissue is immune privileged and does not, in contrast to bone, meniscus or ligaments, cause an immune reaction. The technique has the unique advantage of transplanting viable, mature and mechanically stable hyaline cartilage into the affected area...
November 14, 2017: Der Unfallchirurg
https://www.readbyqxmd.com/read/29134368/-patellofemoral-instability
#3
S F Fucentese
Patellofemoral instability is an extremely limiting pathology in young and active patients. Anatomical reasons for patellar instability, such as high-riding patella, elevated distance from the tibial tuberosity to trochlear groove (TTTG), trochlear dysplasia, insufficient medial patellofemoral ligament (MPFL) and malpositioning of the axes and torsion can lead to chronic patellofemoral instability and must be thoroughly analyzed. The first dislocation can be treated conservatively, with the exception of an osteochondral defect...
November 13, 2017: Der Orthopäde
https://www.readbyqxmd.com/read/29128537/biomaterials-for-articular-cartilage-tissue-engineering-learning-from-biology
#4
REVIEW
A R Armiento, M J Stoddart, M Alini, D Eglin
Articular cartilage is commonly described as a tissue made of up to 80% water, devoid of blood vessels, nerves and lymphatics, and populated by only one cell type: at first glance, an easy tissue for clinicians to repair and for scientists to reproduce in a laboratory. Yet, chondral and osteochondral defects currently remain an open challenge in orthopedics and tissue engineering of the musculoskeletal system, without considering osteoarthritis. Why do we fail in repairing and regenerating articular cartilage? Behind its simple and homogenous appearance articular cartilage hides a heterogeneous composition, a high level of organisation and specific biomechanical properties that taken together make articular cartilage a unique material that we are not able yet to repair or reproduce with high fidelity...
November 8, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29126043/biphasic-bioresorbable-scaffold-trufit-plug-%C3%A2-for-the-treatment-of-osteochondral-lesions-of-talus-6-to-8-year-follow-up
#5
Elvira Di Cave, Pierluigi Versari, Fabio Sciarretta, David Luzon, Lorenzo Marcellini
BACKGROUND: The ideal treatment of osteochondral lesions of the talus (OLT) is debatable. The TruFit plug has been investigated as a potential treatment method for osteochondral defects. This is a biphasic scaffold designed to stimulate cartilage and subchondral bone formation. The purpose of this retrospective study was to investigate the long-term functional and MRI outcomes of the TruFit Plug for the treatment of OLT. METHODS: Twelve consecutive patients treated from March 2007 to April 2009 for OLT were evaluated...
June 3, 2017: Foot
https://www.readbyqxmd.com/read/29125919/autologous-chondrocyte-implantation-sandwich-technique-compared-with-autologous-bone-grafting-for-deep-osteochondral-lesions-in-the-knee
#6
Tom Minas, Takahiro Ogura, Jeff Headrick, Tim Bryant
BACKGROUND: Treating symptomatic osteochondral defects is challenging, especially in young adults with deep (>8-10 mm) empty defects after osteochondritis dissecans (OCD) or collapsed condyles secondary to avascular necrosis (AVN). For this population, osteoarthritis (OA) is inevitable if articular congruence is not restored. PURPOSE: To describe the autologous chondrocyte implantation (ACI) "sandwich" technique with autologous bone grafting (ABG) and compare it with ABG alone for restoration of the osteochondral unit...
November 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29117842/distraction-arthroplasty-in-an-osteochondral-defect-of-the-middle-finger-in-a-juvenile-patient
#7
In Cheul Choi, Jong Woong Park, Kwang Suk Lee, Dong Min Kim
A 13-year-old female patient visited our hospital with a painful distal interphalangeal joint and deformity on her right middle finger. Initial plain radiographs uncovered ulnar-sided subluxation of the distal interphalangeal joint of the right middle finger, and an osteochondral defect was also noted at the articular surface of the distal and middle phalanges. We decided to attempt distraction arthroplasty with an external fixator. Finally postoperative 12-month follow-up plain radiographs showed complete osteochondral regeneration and phalangeal alignment...
December 2017: Journal of Hand Surgery Asian-Pacific Volume
https://www.readbyqxmd.com/read/29114629/knee-osteoarthritis-after-reconstruction-of-isolated-anterior-cruciate-ligament-injuries-a-systematic-literature-review
#8
REVIEW
Compagnoni Riccardo, Catani Fabio, Randelli Pietro
Purpose  The aim of this review was to analyze the current literature on osteoarthritic evolution of knees without any combined meniscal or ligament lesions undergoing anterior cruciate ligament (ACL) reconstruction. Methods  A PubMed/MEDLINE research was performed using the following keywords: "Anterior Cruciate Ligament Reconstruction" [Mesh] AND "Osteoarthritis, Knee" [Mesh]. Only English language literature and articles published after 2005 were included. Studies including concomitant meniscal tears, posterior cruciate or collateral ligament injuries, previous surgery in the affected knees, infections, osteochondral defects, loose bodies, synovial plica syndrome, and posteromedial or posterolateral corner injuries were not considered in this review...
March 2017: Joints
https://www.readbyqxmd.com/read/29110690/autologous-cell-derived-tissue-engineered-cartilage-for-repairing-articular-cartilage-lesions-in-the-knee-study-protocol-for-a-randomized-controlled-trial
#9
Ning Ma, Hongxia Wang, Xian Xu, Yiqun Wan, Yufeng Liu, Mingjie Wang, Wen Yu, Yongjing Dai, Jiang Peng, Quanyi Guo, Changlong Yu, Shibi Lu
BACKGROUND: Spontaneous recovery from articular cartilage injury is difficult, and the ongoing progression of disease can eventually lead to osteoarthritis. Currently, there is no effective non-surgical treatment for articular cartilage injury. Arthroscopic debridement and microfracture surgery are performed for fibrocartilage repair. But fibrocartilage is different from normal articular cartilage, and functional recovery is not satisfactory. Therefore, it is necessary to develop more effective techniques for articular cartilage repair...
November 6, 2017: Trials
https://www.readbyqxmd.com/read/29110501/first-metatarsal-head-osteochondral-defect-treatment-with-particulated-juvenile-cartilage-allograft-transplantation-a-case-series
#10
Bryan Van Dyke, Gregory C Berlet, Justin L Daigre, Christopher F Hyer, Terrence M Philbin
BACKGROUND: Focal damage to articular cartilage, also called an osteochondral defect (OCD), can be a cause of pain and decreased range of motion. Recent advancements have led to transplantation techniques using particulated juvenile articular cartilage allograft. This technique has been applied to the first metatarsal head to a very limited degree, with no published results to our knowledge. The aim of this study was to review the clinical results of patients who underwent particulated juvenile cartilage allograft implantation for first metatarsal head OCDs...
November 1, 2017: Foot & Ankle International
https://www.readbyqxmd.com/read/29103840/the-influence-of-full-thickness-chondral-defects-on-outcomes-following-meniscal-allograft-transplantation-a-comparative-study
#11
Bryan M Saltzman, Maximilian A Meyer, Timothy S Leroux, Matthew E Gilelis, Margot Debot, Adam B Yanke, Brian J Cole
PURPOSE: To compare a series of patients who underwent meniscus allograft transplantation (MAT) with full-thickness chondral defects (FTD) with those with no chondral defect (ND) with regard to the following: change in patient-reported outcomes (PROs) from baseline to 2-year follow-up and baseline to the final follow-up (including comparisons to minimal clinically important differences), complications and complication rates, reoperations and reoperation rates/timing, and failures and time to failure (revision MAT or conversion to total knee arthroplasty)...
November 2, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29100468/treatment-of-knee-osteochondritis-dissecans-with-a-cell-free-biomimetic-osteochondral-scaffold-clinical-and-imaging-findings-at-midterm-follow-up
#12
Francesco Perdisa, Elizaveta Kon, Andrea Sessa, Luca Andriolo, Maurizio Busacca, Maurilio Marcacci, Giuseppe Filardo
BACKGROUND: Osteochondritis dissecans (OCD) is a developmental condition of subchondral bone that may result in secondary separation and instability of the overlying articular cartilage, which in turn may lead to degeneration of the overall joint and early osteoarthritis. Biphasic scaffolds have been developed to address defects of the entire osteochondral unit by reproducing the different biological and functional requirements and guiding the growth of both bone and cartilage. PURPOSE: To evaluate midterm clinical and imaging results after cell-free osteochondral scaffold implantation for the treatment of knee OCD...
November 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29095403/ankle-mri-and-arthroscopy-correlation-with-cartilaginous-defects-and-symptomatic-os-trigonum
#13
Brian D Powell, Minton T Cooper
Arthroscopic intervention of the foot and ankle is used for a growing number of procedures. Magnetic resonance imaging (MRI) can be a helpful technique while detecting pathology before surgical intervention. A common use of MRI is detecting osteochondral lesion of the talus; however, other pathology can be detected including but not limited to symptomatic Os trigonum and subtalar osteochondral defects. An MRI sensitivity and specificity for detecting these pathologies vary. Correlating findings on MRI with arthroscopy is helpful in determining its accuracy and will be discussed in the following case examples...
December 2017: Sports Medicine and Arthroscopy Review
https://www.readbyqxmd.com/read/29057275/clinical-outcomes-of-donor-sites-after-osteochondral-graft-harvest-from-healthy-knees
#14
Yasuaki Nakagawa, Shogo Mukai, Yoshimasa Setoguchi, Tadashi Goto, Taizo Furukawa, Takashi Nakamura
BACKGROUND: The use of autologous osteochondral grafts has become popular in the treatment of small, isolated, well-contained articular cartilage defects. However, donor site morbidity is a problem, and few reports are available of donor site morbidity after mosaicplasty. PURPOSE: To examine the clinical outcomes of donor sites after osteochondral grafts from healthy knees. STUDY DESIGN: Case series; Level of evidence, 4. METHODS: Between September 1997 and September 2011, there were 40 patients (40 knees; 32 men, 8 women; 31 right knees, 9 left knees) with asymptomatic osteochondral graft donor sites used for autologous transfer; all had a follow-up period of >2 years...
October 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/29051901/fresh-osteochondral-allograft-transplantation-for-spontaneous-osteonecrosis-of-the-knee-a-case-series
#15
Luís E P Tírico, Samuel A Early, Julie C McCauley, William D Bugbee
BACKGROUND: Spontaneous osteonecrosis of the knee (SONK) is a clinical entity identified by acute knee pain usually associated with joint effusion, with radiographic findings of a radiolucent defect on the weightbearing area of the femoral condyle. Conservative treatment is initially undertaken; however, surgical procedures are often necessary. Historically, surgical options have included core decompression, cartilage repair, high tibial osteotomy, or joint arthroplasty. Few studies in the literature have reported the use of fresh osteochondral allograft (OCA) for the treatment of SONK lesions...
October 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/29051878/patellofemoral-articulating-osteochondral-kissing-lesion-treated-with-autologous-chondrocyte-implantation-a-case-report
#16
Taylor J Ridley, Christopher T Rud, Jeffrey A Macalena
INTRODUCTION: Autologous chondrocyte implantation (ACI) is an effective treatment for chondral defects of the knee; however, its use in kissing lesions is less well documented. CASE REPORT: A 23-year-old female with a kissing lesion of the patellofemoral compartment on magnetic resonance imaging underwent two-stage ACI to her medial patella (20 mm × 22 mm) and medial trochlea (27 mm × 18 mm). At 1-year follow-up, the patient had returned to all activities with near-complete resolution of symptoms and substantial improvement in clinical outcome scores...
May 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/29048690/large-fresh-osteochondral-allografts-for-the-hip-growing-the-evidence
#17
Lasun O Oladeji, James L Cook, James P Stannard, Brett D Crist
INTRODUCTION: Articular cartilage lesions of the hip are difficult to effectively treat. Osteochondral allograft (OCA) transplantation in the knee has been associated with long-term success, but OCA for the hip has not been extensively studied. Here, we present the clinical and radiological outcomes from a cohort of 10 patients treated with fresh OCA transplants for large osteochondral defects of the femoral head and/or acetabulum. METHODS: 10 patients who had undergone osteochondral allograft transplantation of the femoral head and/or acetabulum at our institution between 2013 and 2016 were identified from our Institutional Review Board-approved registry...
October 17, 2017: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/29047223/regeneration-of-osteochondral-defects-in-vivo-by-a-cell-free-cylindrical-poly-lactide-co-glycolide-scaffold-with-a-radially-oriented-microstructure
#18
Yuankun Dai, Tao Shen, Lie Ma, Dongan Wang, Changyou Gao
A scaffold with an oriented porous architecture to facilitate cell infiltration and bioactive interflow between neo-host tissues is of great importance for in situ inductive osteochondral regeneration. In this study, a poly(lactide-co-glycolide) (PLGA) scaffold with oriented pores in its radial direction (O-PLGA) was fabricated via unidirectional cooling of the PLGA solution in the radial direction, following with lyophilization. Micro-CT evaluation and SEM observation confirmed the radially oriented microtubular pores in the scaffold...
October 19, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29039969/clinical-outcomes-and-failure-rates-of-osteochondral-allograft-transplantation-in-the-knee-a-systematic-review
#19
Filippo Familiari, Mark E Cinque, Jorge Chahla, Jonathan A Godin, Morten Lykke Olesen, Gilbert Moatshe, Robert F LaPrade
BACKGROUND: Cartilage lesions are a significant cause of morbidity and impaired knee function; however, cartilage repair procedures have failed to reproduce native cartilage to date. Thus, osteochondral allograft (OCA) transplantation represents a 1-step procedure to repair large chondral defects without the donor site morbidity of osteochondral autograft transplantation. PURPOSE: To perform a systematic review of clinical outcomes and failure rates after OCA transplantation in the knee at a minimum mean 2 years' follow-up...
October 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29037743/the-effect-of-platelet-rich-fibrin-on-autologous-osteochondral-transplantation-an-in-vivo-porcine-model
#20
S Y Sheu, C H Wang, Y H Pao, Y T Fu, C H Liu, C H Yao, T F Kuo
BACKGROUND: This work aimed to evaluate the efficacy of cartilage transplantation to the medial femoral condyle±platelet-rich fibrin (PRF) augmentation in a porcine model. The hypothesis of the study was that PRF may act as a bioactive cell scaffold to fill defects and enhance cartilage regeneration. METHODS: Thirty-two knees of 16 miniature pigs were randomly assigned to four groups. The critical-size osteochondral defects (8x5mm) in femoral condyle of both knees were treated with one of the following: group 1-untreated controls; group 2-cartilage fragments alone; group 3-PRF alone; group 4-PRFT+cartilage fragments...
October 13, 2017: Knee
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