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Osteochondral defect

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https://www.readbyqxmd.com/read/28919746/in-vitro-and-in-vivo-studies-of-a-novel-bacterial-cellulose-based-acellular-bilayer-nanocomposite-scaffold-for-the-repair-of-osteochondral-defects
#1
Jyoti V Kumbhar, Sachin H Jadhav, Dhananjay S Bodas, Amruta Barhanpurkar-Naik, Mohan R Wani, Kishore M Paknikar, Jyutika M Rajwade
Bacterial cellulose (BC) is a naturally occurring nanofibrous biomaterial which exhibits unique physical properties and is amenable to chemical modifications. To explore whether this versatile material can be used in the treatment of osteochondral defects (OCD), we developed and characterized novel BC-based nanocomposite scaffolds, for example, BC-hydroxyapatite (BC-HA) and BC-glycosaminoglycans (BC-GAG) that mimic bone and cartilage, respectively. In vitro biocompatibility of BC-HA and BC-GAG scaffolds was established using osteosarcoma cells, human articular chondrocytes, and human adipose-derived mesenchymal stem cells...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28915523/-biologic-reconstruction-of-full-sized-cartilage-defects-of-the-hip-a-guideline-from-the-dgou-group-clinical-tissue-regeneration-and-the-hip-committee-of-the-aga
#2
Stefan Fickert, Matthias Aurich, Dirk Albrecht, Peter Angele, Lorenz Büchler, Michael Dienst, Christoph Erggelet, Jürgen Fritz, Christoph Gebhart, Hans Gollwitzer, Moritz Kindler, Christoph Lampert, Henning Madry, Gregor Möckel, Phillip Niemeyer, Jörg Schröder, Christian Sobau, Gunter Spahn, Wolfgang Zinser, Stefan Landgraeber
Background Symptomatic pre-arthritic deformities such as femoroacetabular impingement (FAI) or hip dysplasia often lead to localised cartilage defects and subsequently to osteoarthritis. The present review of the working group "Clinical Tissue Regeneration" of the German Society of Orthopaedics and Trauma (DGOU) and the hip committee of the AGA (German speaking Society for Arthroscopy and Joint Surgery) provides an overview of current knowledge of the diagnosis and surgical treatment of cartilage defects, in order to infer appropriate therapy recommendations for the hip...
September 15, 2017: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/28890259/silk-fibroin-chondroitin-sulfate-scaffold-with-immuno-inhibition-property-for-articular-cartilage-repair
#3
Feifei Zhou, Xianzhu Zhang, Dandan Cai, Jun Li, Qin Mu, Wei Zhang, Shouan Zhu, Yangzi Jiang, Weiliang Shen, Shufang Zhang, Hong Wei Ouyang
The demand of favorable scaffolds has increased for the emerging cartilage tissue engineering. Chondroitin sulfate (CS) and silk fibroin have been investigated and reported with safety and excellent biocompatibility as tissue engineering scaffolds. However, the rapid degradation rate of pure CS scaffolds presents a challenge to effectively recreate neo-tissue similar to natural articular cartilage. Meanwhile the silk fibroin is well used as a structural constituent material because its remarkable mechanical properties, long-lasting in vivo stability and hypoimmunity...
September 7, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28884783/ex-vivo-model-unravelling-cell-distribution-effect-in-hydrogels-for-cartilage-repair
#4
Vivian H M Mouser, Noël M M Dautzenberg, Riccardo Levato, Mattie H P van Rijen, Wouter J A Dhert, Jos Malda, Debby Gawlitta
The implantation of chondrocyte-laden hydrogels is a promising cartilage repair strategy. Chondrocytes can be spatially positioned in hydrogels and thus in defects, while current clinical cell-therapies introduce chondrocytes in the defect depth. The main aim of this study was to evaluate the effect of spatial chondrocyte distribution on the reparative process. To reduce animal experiments, an ex vivo osteochondral plug model was used and evaluated. Finally, the role of the delivered and endogenous cells in the repair process was investigated...
September 8, 2017: ALTEX
https://www.readbyqxmd.com/read/28882956/osteochondral-repair-using-porous-three-dimensional-nanocomposite-scaffolds-in-a-rabbit-model
#5
Beata Żylińska, Ewa Stodolak-Zych, Aleksandra Sobczyńska-Rak, Tomasz Szponder, Piotr Silmanowicz, Mirosław Łańcut, Łukasz Jarosz, Paweł Różański, Izabela Polkowska
AIM: To evaluate the utility of a novel nanocomposite biomaterial consisting of poly-L/D-lactide, and hydroxyapatite bioceramics, enriched with sodium alginate in articular cartilage defect treatment. MATERIALS AND METHODS: The biomaterial was prepared using the method of solvent casting and particle leaching. The study was conducted on 20 New Zealand White rabbits. Experimental osteochondral defects were created in the femoral trochlear grooves and filled with biomaterials...
September 2017: In Vivo
https://www.readbyqxmd.com/read/28867053/osteochondral-autograft-and-allograft-transplantation-in-the-talus
#6
REVIEW
Alan Ng, Kaitlyn Bernhard
Large, symptomatic, focal chondral, and osteochondral lesions of the ankle are treated with osteochondral autograft/allograft transplantation (OAT) procedure, a reconstructive bone grafting technique that uses one or more cylindrical osteochondral grafts from an area of low impact or allograft source and transplants them into the prepared defect site on the talus. This technique allows defects to be filled with mature, hyaline articular cartilage. Acute or chronic chondral or osteochondral lesions can be debilitating; provided here is a review of osteochondral autograft or allograft transplantation...
October 2017: Clinics in Podiatric Medicine and Surgery
https://www.readbyqxmd.com/read/28865575/single-step-arthroscopic-repair-with-cell-free-polymer-based-scaffold-in-osteochondral-lesions-of-the-talus-clinical-and-radiological-results
#7
Ulunay Kanatlı, Ali Eren, Toygun Kağan Eren, Abdurrahman Vural, Dilan Ece Geylan, Ali Yusuf Öner
PURPOSE: To report the clinical and radiological results of patients with talar osteochondral lesions who were treated by microfracture and cell-free scaffold implantation in a single-step arthroscopic surgery. METHODS: Forty patients, treated with a single-step arthroscopic surgery, were evaluated in this single-center-based retrospective study. Patients with degenerative arthritis (n = 1), history of ankle fracture (n = 1), kissing lesions (n = 1), lower extremity deformity (n = 1), and lesions <1...
September 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/28864934/gene-therapy-for-chondral-and-osteochondral-regeneration-is-the-future-now
#8
REVIEW
Daniele Bellavia, F Veronesi, V Carina, V Costa, L Raimondi, A De Luca, R Alessandro, M Fini, G Giavaresi
Gene therapy might represent a promising strategy for chondral and osteochondral defects repair by balancing the management of temporary joint mechanical incompetence with altered metabolic and inflammatory homeostasis. This review analysed preclinical and clinical studies on gene therapy for the repair of articular cartilage defects performed over the last 10 years, focussing on expression vectors (non-viral and viral), type of genes delivered and gene therapy procedures (direct or indirect). Plasmids (non-viral expression vectors) and adenovirus (viral vectors) were the most employed vectors in preclinical studies...
September 1, 2017: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/28860406/vascularised-fibular-grafts-for-reconstruction-of-extremity-bone-defects-after-resection-of-bone-and-soft-tissue-tumours-a-single-institutional-study-of-49-patients
#9
M Emori, M Kaya, H Irifune, N Takahashi, J Shimizu, E Mizushima, Y Murahashi, T Yamashita
AIMS: The aims of this study were to analyse the long-term outcome of vascularised fibular graft (VFG) reconstruction after tumour resection and to evaluate the usefulness of the method. PATIENTS AND METHODS: We retrospectively reviewed 49 patients who had undergone resection of a sarcoma and reconstruction using a VFG between 1988 and 2015. Their mean follow-up was 98 months (5 to 317). Reconstruction was with an osteochondral graft (n = 13), intercalary graft (n = 12), inlay graft (n = 4), or resection arthrodesis (n = 20)...
September 2017: Bone & Joint Journal
https://www.readbyqxmd.com/read/28853913/comparison-of-the-effects-of-osteochondral-autograft-transplantation-with-platelet-rich-plasma-or-platelet-rich-fibrin-on-osteochondral-defects-in-a-rabbit-model
#10
Masahiro Maruyama, Hiroshi Satake, Tomoto Suzuki, Ryusuke Honma, Yasushi Naganuma, Yuya Takakubo, Michiaki Takagi
BACKGROUND: Although osteochondral autograft transplantation (OAT) provides satisfactory outcomes for osteochondral defects, for large defects OAT is often inadequate because of graft availability. Osteochondral allograft transplantation is an alternative treatment for large defects, but this approach is limited by graft storage constraints and carries disease transmission risks. Platelet-rich fibrin (PRF) is a second-generation platelet concentrate, and its positive effect on articular cartilage has been reported...
August 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28852793/-cartilage-repair-of-the-knee-joint
#11
REVIEW
B Rath, J Eschweiler, M Betsch, G Gruber
BACKGROUND: Cartilage defects around the knee joint frequently occur in the region of the medial femoral condyle and the retropatellar cartilage surface. The distinction between local cartilage defects and large area degenerative cartilage lesions is very important for both prognosis and surgical therapy. The size and position of the lesion, the underlying pathomechanism and the age of the patient are very important factors which should be considered in the therapy algorithm for optimal cartilage defect restoration...
August 29, 2017: Der Orthopäde
https://www.readbyqxmd.com/read/28843200/cartilage-oligomeric-matrix-protein-improves-in-vivo-cartilage-regeneration-and-compression-modulus-by-enhancing-matrix-assembly-and-synthesis
#12
Chongyang Wang, Guangwang Liu, Wen Zhang, Wei Wang, Chao Ma, Shen Liu, Cunyi Fan, Xudong Liu
Cartilage oligomeric matrix protein (COMP), an abundant cartilage extracellular matrix protein, plays an important role in mesenchymal chondrogenesis. To test our hypothesis that COMP could promote tissue engineering cartilage regeneration as well as improve cartilaginous mechanical properties, COMP gene transfected rabbit bone marrow mesenchymal stem cells (BMSCs) were used for chondrogenic differentiation in vitro and were implanted with biphasic scaffolds into osteochondral defects of New Zealand white rabbit trochlear grooves for cartilage regeneration in vivo...
August 16, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28819606/intra-articular-loose-body-with-concomitant-bankart-lesion-after-a-traumatic-shoulder-dislocation-a-case-report
#13
Jason B T Lim, Andrew H C Tan
INTRODUCTION: The spectrum of pathoanatomic lesions encountered in anterior shoulder dislocation is broad. There could be a presence of loose bodies, chondral and osteochondral, in the shoulder joint and also concomitant rotator cuff partial tears resulting from acute and chronic shoulder instability. CASE REPORT: We present one case report of a 46-year-old male Chinese with an uncommon case of Bankart lesion, with a full thickness chondral defect over the superior glenoid articular surface manifesting as a large intra-articular loose cartilaginous body...
March 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/28818689/sol-gel-derived-hydroxyapatite-films-over-porous-calcium-polyphosphate-substrates-for-improved-tissue-engineering-of-osteochondral-like-constructs
#14
Whitaik David Lee, Rahul Gawri, Robert M Pilliar, William L Stanford, Rita A Kandel
Integration of in vitro-formed cartilage on a suitable substrate to form tissue-engineered implants for osteochondral defect repair is a considerable challenge. In healthy cartilage, a zone of calcified cartilage (ZCC) act as an intermediary for mechanical force transfer from soft to hard tissue, as well as an effective interlocking structure to better resist interfacial shear forces. We have developed biphasic constructs that consist of scaffold-free cartilage tissue grown in vitro on, and interdigitated with, porous calcium polyphosphate (CPP) substrates...
August 14, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28815373/autologous-nasal-chondrocytes-delivered-by-injectable-hydrogel-for-in-vivo-articular-cartilage-regeneration
#15
Wenliang Chen, Changhua Li, Maoxiu Peng, Bingju Xie, Lei Zhang, Xiaojun Tang
Cell based tissue engineering serves as a promising strategy for articular cartilage repair, which remains a challenge both for researchers and clinicians. The aim of this research was to assess the potential of autologous nasal chondrocytes (NCs) combined with alginate hydrogel as injectable constructs for rabbit articular cartilage repair. Autologous nasal chondrocytes were isolated from rabbit nasal septum, expanded either on monolayer or in 3D alginate hydrogel. In vitro, DNA quantification revealed that NCs can proliferate stable in 3D alginate matrix, but slower than that cultured in monolayer...
August 16, 2017: Cell and Tissue Banking
https://www.readbyqxmd.com/read/28814326/distal-defect-of-the-humerus-a-possible-normal-variant-a-case-report
#16
Akio Sakamoto, Shuichi Matsuda
BACKGROUND: Many normal variants of bones on plain radiographs have been reported. CASE PRESENTATION: In the current report, a 14-year-old Asian girl noticed an occasional slight elbow pain. She had no traumatic episode. Plain radiographs showed a well-defined osteolytic lesion with a sclerotic rim, which was continuous with the normal subarticular bone in the distal humerus. Magnetic resonance imaging revealed that the defect area seen on the plain radiograph showed low-signal to iso-signal intensity on T1-weighted images and slightly high-signal intensity on T2-weighted fat suppression images...
August 17, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28804984/3d-bioprinting-for-cartilage-and-osteochondral-tissue-engineering
#17
REVIEW
Andrew C Daly, Fiona E Freeman, Tomas Gonzalez-Fernandez, Susan E Critchley, Jessica Nulty, Daniel J Kelly
Significant progress has been made in the field of cartilage and bone tissue engineering over the last two decades. As a result, there is real promise that strategies to regenerate rather than replace damaged or diseased bones and joints will one day reach the clinic however, a number of major challenges must still be addressed before this becomes a reality. These include vascularization in the context of large bone defect repair, engineering complex gradients for bone-soft tissue interface regeneration and recapitulating the stratified zonal architecture present in many adult tissues such as articular cartilage...
August 14, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28803652/long-term-follow-up-evaluation-of-autologous-chondrocyte-implantation-for-symptomatic-cartilage-lesions-of-the-knee-a-single-centre-prospective-study
#18
M Berruto, P Ferrua, S Pasqualotto, F Uboldi, A Maione, D Tradati, E Usellini
INTRODUCTION: Autologous Chondrocyte Implantation (ACI) has been the first technique in reconstruction of a valid articular surface. The aim of this study was to evaluate clinical results of this technique at an average follow up of 162±27months (range 88-208) in a group of patients who underwent ACI. MATERIALS AND METHODS: 32 patients were operated between 1997 and 2007 for chondral lesions or osteochondritis dissecans of the knee. Mean size of the defect was 5...
August 4, 2017: Injury
https://www.readbyqxmd.com/read/28800919/similar-outcomes-after-osteochondral-allograft-transplantation-in-anterior-cruciate-ligament-intact-and-reconstructed-knees-a-comparative-matched-group-analysis-with-minimum-2-year-follow-up
#19
Dean Wang, Claire D Eliasburg, Tim Wang, Ryan R Fader, Francesca R Coxe, Mollyann D Pais, Riley J Williams
PURPOSE: To compare failure rates and clinical outcomes of osteochondral allograft transplantation (OCA) in anterior cruciate ligament (ACL)-intact versus ACL-reconstructed knees at midterm follow-up. METHODS: After a priori power analysis, a prospective registry of patients treated with OCA for focal chondral lesions ≥2 cm(2) in size with minimum 2-year follow-up was used to match ACL-reconstructed knees with ACL-intact knees by age, sex, and primary chondral defect location...
August 8, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/28798878/treatment-of-knee-osteochondral-lesions-using-a-novel-clot-of-autologous-plasma-rich-in-growth-factors-mixed-with-healthy-hyaline-cartilage-chips-and-intra-articular-injection-of-prgf
#20
Ramón Cugat, Eduard Alentorn-Geli, Gilbert Steinbacher, Pedro Álvarez-Díaz, Xavier Cuscó, Roberto Seijas, David Barastegui, Jordi Navarro, Patricia Laiz, Montserrat García-Balletbó
Knee cartilage or osteochondral lesions are common and challenging injuries. To date, most symptomatic lesions warrant surgical treatment. We present two cases of patients with knee osteochondral defects treated with a one-step surgical procedure consisting of an autologous-based matrix composed of healthy hyaline cartilage chips, mixed plasma poor-rich in platelets clot, and plasma rich in growth factors (PRGF). Both patients returned to playing soccer at the preinjury activity level and demonstrated excellent defect filling in both magnetic resonance imaging and second-look arthroscopy (in one of them)...
2017: Case Reports in Orthopedics
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