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Osteochondral defect

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https://www.readbyqxmd.com/read/27906096/biological-and-functional-evaluation-of-a-novel-pyrolytic-carbon-implant-for-the-treatment-of-focal-osteochondral-defects-in-the-medial-femoral-condyle-assessment-in-a-canine-model
#1
Samantha L Salkeld, Laura P Patron, Joan C Lien, Stephen D Cook, Deryk G Jones
BACKGROUND: Osteochondral defects continue to be a clinical treatment challenge, and when left untreated, may cause pain and functional impairment. Pyrolytic carbon is a unique isotropic biomaterial used in heart valve and small joint replacements due to its excellent wear properties and biocompatibility with bone and articular cartilage. Therefore, a proposed solution is to utilize a focal pyrolytic carbon hemiarthroplasty implant as an alternative resurfacing treatment strategy for isolated cartilage lesions...
December 1, 2016: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/27893924/deciding-how-best-to-treat-cartilage-defects
#2
Lucy Oliver-Welsh, Justin W Griffin, Maximilian A Meyer, Matthew E Gitelis, Brian J Cole
The decision-making regarding and treatment of cartilage abnormalities requires a systematic approach. This article reviews the concepts and principles that guide the management of this complex problem. The precise incidence, demographics, and progression of cartilage lesions have not been clearly delineated. Pursuing a patient-centered approach that considers the available nonsurgical and surgical options remains the cornerstone of patient care. The importance of determining concomitant knee pathologies, the proper interpretation and implications of imaging findings, and an accurate determination of the intra-articular and subchondral findings represent the primary elements of the decision analysis...
January 0: Orthopedics
https://www.readbyqxmd.com/read/27891511/diagnostic-value-of-ct-arthrography-for-evaluation-of-osteochondral-lesions-at-the-ankle
#3
Jan S Kirschke, Sepp Braun, Thomas Baum, Christian Holwein, Christoph Schaeffeler, Andreas B Imhoff, Ernst J Rummeny, Klaus Woertler, Pia M Jungmann
Background. To retrospectively determine the diagnostic value of computed tomography arthrography (CTA) of the ankle in the evaluation of (osteo)chondral lesions in comparison to conventional magnetic resonance imaging (MRI) and intraoperative findings. Methods. A total of N = 79 patients had CTAs and MRI of the ankle; in 17/79 cases surgical reports with statements on cartilage integrity were available. Cartilage lesions and bony defects at talus and tibia were scored according to defect depth and size by two radiologists...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27826762/matrix-based-autologous-chondrocyte-implantation-in-children-and-adolescents-a-match-paired-analysis-in-a-follow-up-over-three-years-post-operation
#4
Thomas Richard Niethammer, Martin Holzgruber, Mehmet Fatih Gülecyüz, Patrick Weber, Matthias Frank Pietschmann, Peter Ernst Müller
PURPOSE: The aim of this study is the investigation of the clinical results after third generation autologous chondrocyte implantation in the knee in a follow-up over three years post-operation. Our primary focus is on the effects of this procedure on children and adolescent patients as there is a lack of knowledge regarding the clinical outcomes in children/adolescents in particular when compared with adults. METHODS: A total of 40 patients (43 defects) <20 years with cartilage defects of the knee were treated with third generation ACI (Novocart® 3D)...
November 8, 2016: International Orthopaedics
https://www.readbyqxmd.com/read/27824874/effect-of-transplanting-various-concentrations-of-a-composite-of-human-umbilical-cord-blood-derived-mesenchymal-stem-cells-and-hyaluronic-acid-hydrogel-on-articular-cartilage-repair-in-a-rabbit-model
#5
Yong-Beom Park, Chul-Won Ha, Jin-A Kim, Ji-Heon Rhim, Yong-Geun Park, Jun Young Chung, Han-Jun Lee
BACKGROUND: Mesenchymal stem cells (MSCs) are known to have therapeutic potential for cartilage repair. However, the optimal concentration of MSCs for cartilage repair remains unclear. Therefore, we aimed to explore the feasibility of cartilage repair by human umbilical cord blood-derived MSCs (hUCB-MSCs) and to determine the optimal concentrations of the MSCs in a rabbit model. METHODS: Osteochondral defects were created in the trochlear groove of femur in 55 rabbits...
2016: PloS One
https://www.readbyqxmd.com/read/27813021/bone-marrow-aspirate-concentrate-for-the-treatment-of-osteochondral-lesions-of-the-talus-a-systematic-review-of-outcomes
#6
REVIEW
Jorge Chahla, Mark E Cinque, Jason M Shon, Daniel J Liechti, Lauren M Matheny, Robert F LaPrade, Thomas O Clanton
BACKGROUND: The goal of this perform a systematic review on the outcomes of bone marrow aspirate concentrate (BMAC) for the treatment of chondral defects and osteoarthritis (OA) of the talus. RESULTS: The systematic search performed identified 47 studies after duplicates were removed. After inclusion criteria were applied four studies were considered for insightful analysis for the treatment of focal chondral defects in the foot and ankle with the use of BMAC. Three studies were retrospective and one study was prospective in nature...
December 2016: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/27813019/knee-donor-site-morbidity-after-mosaicplasty-a-systematic-review
#7
REVIEW
Renato Andrade, Sebastiano Vasta, Rogério Pereira, Hélder Pereira, Rocco Papalia, Mustafa Karahan, J Miguel Oliveira, Rui L Reis, João Espregueira-Mendes
BACKGROUND: Mosaicplasty has been associated with good short- to long-term results. Nevertheless, the osteochondral harvesting is restricted to the donor-site area available and it may lead to significant donor-site morbidity. PURPOSE: Provide an overview of donor-site morbidity associated with harvesting of osteochondral plugs from the knee joint in mosaicplasty procedure. METHODS: Comprehensive search using Pubmed, Cochrane Library, SPORTDiscus and CINAHL databases was carried out through 10(th) October of 2016...
December 2016: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/27806676/the-role-of-cell-seeding-bio-scaffolds-and-the-in-vivo-microenvironment-in-the-guided-generation-of-osteochondral-composite-tissue
#8
Jiao Wei, Tanja Herrler, Kai Liu, Dong Han, Mei Yang, Chuanchang Dai, Qing Feng Li
Tissue engineering based on cell seeding, bio-scaffolds, and growth factors has been widely applied for the reconstruction of tissue defects. Recent progress has fueled in vivo tissue engineering techniques in becoming hot topics in regenerative medicine and reconstructive surgery. To improve the efficacy of tissue engineering, we here investigated the roles of cell seeding, bio-scaffolds, growth factors, and in-vivo microenvironment in tissue regeneration. Bone marrow derived stem cells (BMSCs), allogenic demineralized bone matrix (DBM) as bio-scaffold, and growth factors bone morphogenetic protein 2/ transforming growth factor (BMP-2/TGF-β1), and the in-vivo microenvironment of rib periosteum and perichondrium were used in different combinations for the generation of osteochondral composite tissue...
November 2, 2016: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/27793804/osteochondral-allograft-donor-host-matching-by-the-femoral-condyle-radius-of-curvature
#9
Derek T Bernstein, Craig A O'Neill, Ryan S Kim, Hugh L Jones, Philip C Noble, Joshua D Harris, Patrick C McCulloch
BACKGROUND: Conventional osteochondral allograft (OCA) matching, requiring orthotopic, size-matched condyles, and narrow surgical time windows often prohibit timely transplantation. HYPOTHESIS: The femoral condyle radius of curvature (RoC) is an appropriate, isolated criterion for donor-host matching in fresh OCAs, potentially enhancing matching efficiency when compared with conventional matching techniques. STUDY DESIGN: Descriptive laboratory study...
October 28, 2016: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/27789340/macroscopic-cartilage-repair-scoring-of-defect-fill-integration-and-total-points-correlate-with-corresponding-items-in-histological-scoring-systems-a-study-in-adult-sheep
#10
Lars Goebel, Patrick Orth, Magali Cucchiarini, Dietrich Pape, Henning Madry
OBJECTIVE: To correlate osteochondral repair assessed by validated macroscopic scoring systems with established semiquantitative histological analyses in an ovine model and to test the hypothesis that important macroscopic individual categories correlate with their corresponding histological counterparts. METHODS: In the weight-bearing portion of medial femoral condyles (n = 38) of 19 female adult Merino sheep (age 2 to 4 years; weight 70 ± 20 kg) full-thickness chondral defects were created (size 4 x 8 mm; ICRS grade 3C) and treated with Pridie drilling...
October 24, 2016: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/27789339/single-stage-cell-based-cartilage-repair-in-a-rabbit-model-cell-tracking-and-in-vivo-chondrogenesis-of-human-umbilical-cord-blood-derived-mesenchymal-stem-cells-and-hyaluronic-acid-hydrogel-composite
#11
Y B Park, C W Ha, J A Kim, W J Han, J H Rhim, H J Lee, K J Kim, Y G Park, J Y Chung
OBJECTIVE: Human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) have gained popularity as a promising cell source for regenerative medicine, but limited in vivo studies have reported cartilage repair. In addition, the roles of MSCs in cartilage repair are not well-understood. The purpose of this study was to investigate the feasibility of transplanting hUCB-MSCs and hyaluronic acid (HA) hydrogel composite to repair articular cartilage defects in a rabbit model and determine whether the transplanted cells persisted or disappeared from the defect site...
October 24, 2016: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/27771489/tailoring-biomaterial-scaffolds-for-osteochondral-repair
#12
Sandra Camarero-Espinosa, Justin Cooper-White
Articular cartilage is a mechanically and structurally complex, lubricious tissue that permits load-bearing and frictionless movement of our joints upon articulation. Unfortunately, cartilage is unable to properly self-heal as a result of acute trauma or damage, resulting in many cases in significant pain, reduction in physical activity and quality of life for the patient. Due to the inability of resident cells to repair damaged osteochondral tissue, researchers have focused on utilizing endogenously or exogenously sourced cells (chondrocytes or tissue-derived mesenchymal stem cells), with or without scaffolds, to encourage the secretion of extracellular matrix (ECM) that replicates this highly anisotropic osteochondral tissue, in which the phenotype of the cells and the composition and orientation of the ECM varies along its depth...
October 19, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27770610/in-vivo-evaluation-of-stem-cell-aggregates-on-osteochondral-regeneration
#13
BanuPriya Sridharan, Amy D Laflin, Michael A Holtz, Donna M Pacicca, Nicholas K Wischmeier, Michael S Detamore
To date, many osteochondral regenerative approaches have utilized varied combinations of biocompatible materials and cells to engineer cartilage. Even in cell-based approaches, to date, no study has utilized stem cell aggregates alone for regenerating articular cartilage. Thus, the purpose of this study was to evaluate the performance of a novel stem cell-based aggregate approach in a fibrin carrier to regenerate osteochondral defects in the Sprague-Dawley rat trochlear groove model. Two different densities of rat bone marrow mesenchymal stem cell (rBMSC) aggregates were fabricated by the hanging drop technique...
October 22, 2016: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/27769090/-treatment-of-osteochondral-lesions-in-the-ankle-a-guideline-from-the-group-clinical-tissue-regeneration-of-the-german-society-of-orthopaedics-and-traumatology-dgou
#14
M Aurich, D Albrecht, P Angele, C Becher, S Fickert, J Fritz, P E Müller, P Niemeyer, M Pietschmann, G Spahn, M Walther
Background: Osteochondral lesions (OCL) of the ankle are a common cause of ankle pain. Although the precise pathophysiology has not been fully elucidated, it can be assumed that a variety of factors are responsible, mainly including traumatic events such as ankle sprains. Advances in arthroscopy and imaging techniques, in particular magnetic resonance imaging (MRI), have improved the possibilities for the diagnosis of OCLs of the ankle. Moreover, these technologies aim at developing new classification systems and modern treatment strategies...
October 21, 2016: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/27768805/ex-vivo-culture-platform-for-assessment-of-cartilage-repair-treatment-strategies
#15
Andrea Schwab, Annick Meeuwsen, Franziska Ehlicke, Jan Hansmann, Lars Mulder, Anthal Smits, Heike Walles, Linda Kock
There is a great need for valuable ex vivo models that allow for assessment of cartilage repair strategies to reduce the high number of animal experiments. In this paper we present three studies with our novel ex vivo osteochondral culture platform. It consists of two separated media compartments for cartilage and bone which better represents the in vivo situation and enables supply of specific factors to the different needs of bone and cartilage. We investigated whether separation of the cartilage and bone compartments and/or culture media results in the maintenance of viability, structural and functional properties of cartilage tissue (study A)...
October 21, 2016: ALTEX
https://www.readbyqxmd.com/read/27767021/development-and-fabrication-of-a-two-layer-tissue-engineered-osteochondral-composite-using-hybrid-hydrogel-cancellous-bone-scaffolds-in-a-spinner-flask
#16
Kedong Song, Wenfang Li, Hai Wang, Yu Zhang, Liying Li, Yiwei Wang, Hong Wang, Ling Wang, Tianqing Liu
Biological treatment using engineered osteochondral composites has received growing attention for the repair of cartilage defects. Osteochondral composites combined with a dynamic culture provide great potential for improving the quality of constructs and cartilage regeneration as dynamic conditions mimic the in vivo condition where cells were constantly subjected to mechanical and chemical stimulation. In the present study, biophasic composites were produced in vitro consisting of cell-hydrogel (CH) and cell-cancellous bone (CB) constructs, followed by culturing in a dynamic system in a spinner flask...
October 21, 2016: Biomedical Materials
https://www.readbyqxmd.com/read/27761182/intra-articular-osteoid-osteoma-at-the-femoral-trochlea-treated-with-osteochondral-autograft-transplantation
#17
Joshua J Leeman, Daria Motamedi, Ben Wildman-Tobriner, Richard J O'Donnell, Thomas M Link
We present the case of an intra-articular osteoid osteoma at the femoral trochlea. Intra-articular osteoid osteoma can present a diagnostic challenge both clinically and with imaging because it presents differently from the classic cortical osteoid osteoma. Given the lesion's proximity to overlying cartilage, the patient underwent resection of the lesion with osteochondral autograft transplantation at the surgical defect. A comprehensive literature review and discussion of intra-articular osteoma will be provided...
June 2016: Journal of Radiology Case Reports
https://www.readbyqxmd.com/read/27731928/effects-of-a-cell-free-method-using-collagen-vitrigel-incorporating-tgf-%C3%AE-1-on-articular-cartilage-repair-in-a-rabbit-osteochondral-defect-model
#18
Hideyuki Maruki, Masato Sato, Toshiaki Takezawa, Yoshiki Tani, Munetaka Yokoyama, Takumi Takahashi, Eriko Toyoda, Eri Okada, Shigehisa Aoki, Joji Mochida, Yoshiharu Kato
We studied the ability of collagen vitrigel material to repair cartilage in vivo when used alone or with transforming growth factor-β (TGF-β). We measured the time course and quantity of TGF-β1 released from the collagen vitrigel in vitro to quantify the controlled release of TGF-β1. Over 14 days, 0.91 ng of TGF-β was released from the collagen vitrigel. Osteochondral defects were made in the femoral trochlear groove in 36 Japanese white rabbits, which were divided into three groups: untreated group (group A), collagen vitrigel-implanted group (group B), and TGF-β1-incorporated collagen vitrigel-implanted group (group C)...
October 12, 2016: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/27726748/ct-and-mr-imaging-of-the-postoperative-ankle-and-foot
#19
Gary M LiMarzi, Kurt F Scherer, Michael L Richardson, David R Warden, Christopher W Wasyliw, Jack A Porrino, Christopher R Pettis, Gideon Lewis, Christopher C Mason, Laura W Bancroft
A variety of surgical procedures exist for repair of both traumatic and degenerative osseous and soft-tissue pathologic conditions involving the foot and ankle. It is necessary for the radiologist to be familiar with these surgical procedures, so as to assess structural integrity, evaluate for complicating features, and avoid diagnostic pitfalls. Adequate interpretation of postoperative changes often requires access to surgical documentation to evaluate not only the surgery itself but the expected timeline for resolution of normal postoperative changes versus progressive disease...
October 2016: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/27716360/differences-in-joint-morphology-between-the-knee-and-ankle-affect-the-repair-of-osteochondral-defects-in-a-rabbit-model
#20
Manami Makitsubo, Nobuo Adachi, Tomoyuki Nakasa, Tomohiro Kato, Ryo Shimizu, Mitsuo Ochi
BACKGROUND: Although differences in the results of the bone marrow stimulation technique between the knee and ankle have been reported, a detailed mechanism for those differences has not been clarified. The purpose of this study was to examine whether morphological differences between the knee and ankle joint affect the results of drilling as treatment for osteochondral defects in a rabbit model. METHODS: Osteochondral defects were created at the knee and ankle joint in the rabbit...
October 4, 2016: Journal of Orthopaedic Surgery and Research
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