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Osteochondral defect

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https://www.readbyqxmd.com/read/28441305/step-by-step-technique-for-segmental-reconstruction-of-reverse-hill-sachs-lesions-using-homologous-osteochondral-allograft
#1
Hassanin Alkaduhimi, Michel P J van den Bekerom, Derek F P van Deurzen
Posterior shoulder dislocations are accompanied by high forces and can result in an anteromedial humeral head impression fracture called a reverse Hill-Sachs lesion. This reverse Hill-Sachs lesion can result in serious complications including posttraumatic osteoarthritis, posterior dislocations, osteonecrosis, persistent joint stiffness, and loss of shoulder function. Treatment is challenging and depends on the amount of bone loss. Several techniques have been reported to describe the surgical treatment of lesions larger than 20%...
April 24, 2017: Techniques in Hand & Upper Extremity Surgery
https://www.readbyqxmd.com/read/28419816/high-rate-of-osteoarthritis-after-osteochondritis-dissecans-fragment-excision-compared-with-surgical-restoration-at-a-mean-16-year-follow-up
#2
Thomas L Sanders, Ayoosh Pareek, Mitchel R Obey, Nicholas R Johnson, James L Carey, Michael J Stuart, Aaron J Krych
BACKGROUND: Osteochondritis dissecans (OCD) is a disorder of subchondral bone that causes adverse effects on the overlying cartilage and commonly affects the knee. The incidence of OCD and its long-term effect on the knee joint are controversial. Hypothesis/Purpose: The purpose of this study was to (1) evaluate the rate of osteoarthritis and knee arthroplasty in a population-based cohort of patients with OCD lesions treated operatively and (2) evaluate factors that may predispose patients to knee osteoarthritis and arthroplasty...
April 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28411451/anisotropic-tough-double-network-hydrogel-from-fish-collagen-and-its-spontaneous-in%C3%A2-vivo-bonding-to-bone
#3
Md Tariful Islam Mredha, Nobuto Kitamura, Takayuki Nonoyama, Susumu Wada, Keiko Goto, Xi Zhang, Tasuku Nakajima, Takayuki Kurokawa, Yasuaki Takagi, Kazunori Yasuda, Jian Ping Gong
Soft supporting tissues in the human body, such as cartilages and ligaments, are tough materials and firmly fixed to bones. These soft tissues, once injured, cannot regenerate spontaneously in vivo. Developing tough and biocompatible hydrogels as artificial soft supporting tissues would substantially improve outcomes after soft tissue injury. Collagen is the main rigid component in soft connective tissues which is organized in various hierarchical arrays. We have successfully developed a novel class of collagen fibril-based tough hydrogels based on the double network (DN) concept using swim bladder collagen (SBC) extracted from Bester sturgeon fish...
July 2017: Biomaterials
https://www.readbyqxmd.com/read/28409096/ankle-arthroscopy-with-microfracture-for-osteochondral-defects-of-the-talus
#4
Suman Medda, Ian M Al'Khafaji, Aaron T Scott
Therapeutic arthroscopy with microfracture leads to fibrocartilaginous repair and is an effective treatment of osteochondral lesions of the talus. A full diagnostic arthroscopy is performed, and then attention is turned to the osteochondral defect. We describe in detail patient positioning, ankle distraction, portal placement, steps of the diagnostic arthroscopy, and the technique of microfracture. We then discuss the special considerations to be taken regarding the use of a distractor, protection of neurovascular structures, and the indications for microfracture...
February 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/28399642/acute-tears-of-the-tibialis-posterior-tendon-following-ankle-sprain
#5
Lyle T Jackson, Linda J Dunaway, Gregory A Lundeen
BACKGROUND: Traumatic tears of the tibialis posterior (TP) tendon following an ankle sprain are rare. The purpose of this study was to report our case series of TP tendon tears following an ankle sprain. METHODS: Patients with persistent TP tendon pain after an ankle sprain were retrospectively identified over a 4-year period and reviewed. A comparison of magnetic resonance imaging (MRI) interpretations by a radiologist and surgeon was made. Patients failing conservative management underwent operative repair of the TP tendon tear and concomitant pathology...
April 1, 2017: Foot & Ankle International
https://www.readbyqxmd.com/read/28399641/optimization-of-degradation-profile-for-new-scaffold-in-cartilage-repair
#6
Sarav S Shah, Haixiang Liang, Sandeep Pandit, Zalak Parikh, John A Schwartz, Todd Goldstein, Lawrence P Lavelle, Arindam Datta, Daniel A Grande
Objective To establish whether a novel biomaterial scaffold with tunable degradation profile will aid in cartilage repair of chondral defects versus microfracture alone in vitro and in a rat model in vivo. Design In vitro-Short- and long-term degradation scaffolds were seeded with culture expanded articular chondrocytes or bone marrow mesenchymal stem cells. Cell growth and differentiation were evaluated with cell morphological studies and gene expression studies. In vivo-A microfracture rat model was used in this study to evaluate the repair of cartilage and subchondral bone with the contralateral knee serving as the empty control...
April 1, 2017: Cartilage
https://www.readbyqxmd.com/read/28396070/novel-pathogenic-acan-variants-in-non-syndromic-short-stature-patients
#7
Xuyun Hu, Baoheng Gui, Jiasun Su, Hongdou Li, Niu Li, Tingting Yu, Qinle Zhang, Yufei Xu, Guoqiang Li, Yulin Chen, Yanrong Qing, Chuan Li, Jingsi Luo, Xin Fan, Yu Ding, Juan Li, Jian Wang, Xiumin Wang, Shaoke Chen, Yiping Shen
BACKGROUND: Pathogenic variants of ACAN have been reported to cause spondyloepiphyseal dysplasia Kimberley type, spondyloepimetaphyseal dysplasia, familial osteochondritis dissecans and idiopathic short stature with normal to advanced bone age. A recent international cohort study significantly expanded the ACAN mutation spectrum, further delineated the heterogeneous clinical characteristics of ACAN mutation patients. The prevalence of ACAN mutation in short stature patients is yet unknown...
April 7, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28372295/comparison-of-msc-properties-in-two-different-hydrogels-impact-of-mechanical-properties
#8
Hao Yu, Ghislaine Cauchois, Nicolas Louvet, Yun Chen, Rachid Rahouadj, Céline Huselstein
Once articular cartilage is damaged, it has poor ability to heal. At present, alginate-based hydrogels have 3D-dimensional physical structures with great potential for applications in carilage tissue engineering. For osteochondral defect, it will be necessary to use stratified scaffold to mimic zonal organization of cartilage. This study aims to compare the characteristics of alginate (Alg)/hyaluronic acid (HA) hydrogels which will mimic cartilage with alginate (Alg)/hydroxyapatite (Hap) hydrogels which will mimic subchondral bone...
2017: Bio-medical Materials and Engineering
https://www.readbyqxmd.com/read/28359897/chitosan-hyaluronic-acid-hydrogel-for-cartilage-repair
#9
Neethu Mohan, P V Mohanan, A Sabareeswaran, Prabha Nair
The current study investigates the potential of chitosan-hyaluronic acid dialdehyde hydrogels for in vivo cartilage regeneration following two different approaches: Gel alone for cartilage regeneration or combination of chondrocytes and gel for cartilage repair. Critical size osteochondral defects were created in knee joints of Newzealand White rabbits. Allogenic rabbit chondrocytes were encapsulated in hydrogels and gel or gel+cells were implanted in defects aseptically. The regenerated cartilage was analyzed after 12 weeks of implantation...
March 27, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28355678/surgical-correction-of-articular-damage-in-the-knee-osteoarticular-transplantation-to-joint-reconstruction
#10
Xue Susan Bai, Jonelle M Thomas, Alice S Ha
Injuries of the articular cartilage remain difficult to treat and can range from small articular cartilage defects to end-stage severe osteoarthritis. In this review, we discuss various surgical treatment options including imaging features and associated complications. Specifically, we review microfracture, acellular matrix-induced microfracture, autologous osteochondral transplantation, osteochondral allograft transplantation, autologous chondrocyte implantation, along with various forms of knee arthroplasties...
April 2017: Seminars in Musculoskeletal Radiology
https://www.readbyqxmd.com/read/28345610/early-loss-of-subchondral-bone-following-microfracture-is-counteracted-by-bone-marrow-aspirate-in-a-translational-model-of-osteochondral-repair
#11
Liang Gao, Patrick Orth, Kathrin Müller-Brandt, Lars K H Goebel, Magali Cucchiarini, Henning Madry
Microfracture of cartilage defects may induce alterations of the subchondral bone in the mid- and long-term, yet very little is known about their onset. Possibly, these changes may be avoided by an enhanced microfracture technique with additional application of bone marrow aspirate. In this study, full-thickness chondral defects in the knee joints of minipigs were either treated with (1) debridement down to the subchondral bone plate alone, (2) debridement with microfracture, or (3) microfracture with additional application of bone marrow aspirate...
March 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28344533/diagnostic-wrist-arthroscopy-for-nonspecific-wrist-pain
#12
Amin Mohamadi, Femke M A P Claessen, Sezai Ozkan, Gregory P Kolovich, David Ring, Neal C Chen
Background: This study addresses the prevalence of discrete pathophysiology accounting for patients' symptoms during diagnostic wrist arthroscopy in individuals with wrist pain without a specific preoperative diagnosis. Secondarily, we determined the number and type of surgeries subsequent to diagnostic wrist arthroscopy. Methods: Between January 2000 and January 2015, 135 diagnostic wrist arthroscopies were performed by 12 surgeons in 3 urban academic hospitals. We recorded the diagnostic findings of diagnostic wrist arthroscopy and any subsequent surgeries...
March 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/28340661/medial-femoral-trochlea-osteochondral-flap-applications-for-scaphoid-and-lunate-reconstruction
#13
REVIEW
James P Higgins, Heinz K Bürger
Vascularized osteochondral flaps are a new technique described for the reconstruction of challenging articular defects of the carpus. The medial femoral trochlea osteochondral flap is supplied by the descending geniculate artery. This osteochondral flap has shown promise in the treatment of recalcitrant scaphoid proximal pole nonunions and advanced avascular necrosis of the lunate. The anatomy, surgical technique, and results are discussed, with clinical cases provided.
April 2017: Clinics in Plastic Surgery
https://www.readbyqxmd.com/read/28319248/cyclic-tensile-strain-enhances-human-mesenchymal-stem-cell-smad-2-3-activation-and-tenogenic-differentiation-in-anisotropic-collagen-glycosaminoglycan-scaffolds
#14
W G Grier, A S Moy, B A Harley
Stem cell research arose from the need to explore new therapeutic possibilities for intractable and lethal diseases. Although musculoskeletal disorders are basically nonlethal, their high prevalence and relative ease of performing clinical trials have facilitated the clinical application of stem cells in this field. However, few reliable clinical studies have been published, despite the plethora of in vitro and preclinical studies in stem cell research for regenerative medicine in the musculoskeletal system...
March 20, 2017: European Cells & Materials
https://www.readbyqxmd.com/read/28272938/comparison-of-2-different-formulations-of-artificial-bone-for-a-hybrid-implant-with-a-tissue-engineered-construct-derived-from-synovial-mesenchymal-stem-cells
#15
Kazunori Shimomura, Yu Moriguchi, Ryosuke Nansai, Hiromichi Fujie, Wataru Ando, Shuji Horibe, David A Hart, Alberto Gobbi, Hideki Yoshikawa, Norimasa Nakamura
BACKGROUND: Previously, we developed a hybrid implant composed of hydroxyapatite (HA)-based artificial bone coupled with a mesenchymal stem cell (MSC)-based scaffold-free tissue-engineered construct (TEC) and demonstrated its feasibility for osteochondral repair. Beta-tricalcium phosphate (βTCP) may be a promising alternative to HA, as it is a highly biocompatible material and is resorbed more rapidly than HA in vivo. HYPOTHESIS: A βTCP-based hybrid TEC implant will exhibit superior osteochondral repair when directly compared with an HA-based hybrid implant, as tested using a rabbit osteochondral defect model...
March 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28266690/lengthening-primary-cilia-enhances-cellular-mechanosensitivity
#16
G-I Im
Stem cell research arose from the need to explore new therapeutic possibilities for intractable and lethal diseases. Although musculoskeletal disorders are basically nonlethal, their high prevalence and relative ease of performing clinical trials have facilitated the clinical application of stem cells in this field. However, few reliable clinical studies have been published, despite the plethora of in vitro and preclinical studies in stem cell research for regenerative medicine in the musculoskeletal system...
February 21, 2017: European Cells & Materials
https://www.readbyqxmd.com/read/28263667/one-step-treatment-for-patellar-cartilage-defects-with-a-cell-free-osteochondral-scaffold
#17
Francesco Perdisa, Giuseppe Filardo, Andrea Sessa, Maurizio Busacca, Stefano Zaffagnini, Maurilio Marcacci, Elizaveta Kon
BACKGROUND: The treatment of symptomatic cartilage defects of the patella is particularly challenging, and no gold standard is currently available. PURPOSE: To evaluate the clinical results of a biphasic cell-free collagen-hydroxyapatite scaffold and to evaluate osteochondral tissue regeneration with magnetic resonance imaging (MRI). STUDY DESIGN: Case series; Level of evidence, 4. METHODS: Thirty-four patients (18 men and 16 women; mean ± SD: age, 30...
March 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28261617/repair-of-osteochondral-defects-using-human-umbilical-cord-wharton-s-jelly-derived-mesenchymal-stem-cells-in-a-rabbit-model
#18
Shuyun Liu, Yanhui Jia, Mei Yuan, Weimin Guo, Jingxiang Huang, Bin Zhao, Jiang Peng, Wenjing Xu, Shibi Lu, Quanyi Guo
Umbilical cord Wharton's jelly-derived mesenchymal stem cell (WJMSC) is a new-found mesenchymal stem cell in recent years with multiple lineage potential. Due to its abundant resources, no damage procurement, and lower immunogenicity than other adult MSCs, WJMSC promises to be a good xenogenous cell candidate for tissue engineering. This in vivo pilot study explored the use of human umbilical cord Wharton's jelly mesenchymal stem cells (hWJMSCs) containing a tissue engineering construct xenotransplant in rabbits to repair full-thickness cartilage defects in the femoral patellar groove...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28258115/the-effect-of-systemic-administration-of-g-csf-on-a-full-thickness-cartilage-defect-in-a-rabbit-model-msc-proliferation-as-presumed-mechanism-g-csf-for-cartilage-repair
#19
T Sasaki, R Akagi, Y Akatsu, T Fukawa, H Hoshi, Y Yamamoto, T Enomoto, Y Sato, R Nakagawa, K Takahashi, S Yamaguchi, T Sasho
OBJECTIVES: The aim of this study was to investigate the effect of granulocyte-colony stimulating factor (G-CSF) on mesenchymal stem cell (MSC) proliferation in vitro and to determine whether pre-microfracture systemic administration of G-CSF (a bone marrow stimulant) could improve the quality of repaired tissue of a full-thickness cartilage defect in a rabbit model. METHODS: MSCs from rabbits were cultured in a control medium and medium with G-CSF (low-dose: 4 μg, high-dose: 40 μg)...
March 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28235767/canine-articular-cartilage-regeneration-using-mesenchymal-stem-cells-seeded-on-platelet-rich-fibrin-macroscopic-and-histological-assessments
#20
D Kazemi, K Shams Asenjan, N Dehdilani, H Parsa
OBJECTIVES: Mesenchymal stem cells have the ability to differentiate into various cell types, and thus have emerged as promising alternatives to chondrocytes in cell-based cartilage repair methods. The aim of this experimental study was to investigate the effect of bone marrow derived mesenchymal stem cells combined with platelet rich fibrin on osteochondral defect repair and articular cartilage regeneration in a canine model. METHODS: Osteochondral defects were created on the medial femoral condyles of 12 adult male mixed breed dogs...
February 2017: Bone & Joint Research
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