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Bradley Randleman

Paolo Vinciguerra, Fabrizio I Camesasca, Riccardo Vinciguerra, Samuel Arba-Mosquera, Ingrid Torres, Emanuela Morenghi, J Bradley Randleman
PURPOSE: To compare visual outcomes and postoperative aberrations after surface ablation performed with a 750-Hz versus a 1,050-Hz excimer laser coupled with an ablation software designed to reduce corneal surface irregularity. METHODS: Retrospective comparative trial of myopic eyes that had refractive surgery consecutively treated with transepithelial advanced surface ablation with a 750-Hz excimer laser (750 group) versus a 1,050-Hz excimer laser coupled with the Smart Pulse Technology ablation software (SPT group)...
February 1, 2017: Journal of Refractive Surgery
Ali Vahdati, Ibrahim Seven, Naveen Mysore, J Bradley Randleman, William J Dupps
PURPOSE: To develop a computational approach to corneal biomechanical risk analysis in refractive surgery and to investigate its utility in an enigmatic case of unilateral ectasia after bilateral LASIK. METHODS: Preoperative corneal elevation datasets from both eyes of a patient who developed unilateral post-LASIK ectasia were used to construct geometrically patient-specific, microstructurally motivated finite element models. Models were assessed before and after implementation of case-specific treatment parameters for interocular differences in corneal geometry and strain behavior under physiological loading conditions...
December 1, 2016: Journal of Refractive Surgery
Claudia E Perez-Straziota, J Bradley Randleman
PURPOSE OF REVIEW: This article describes different strategies for corneal measurements and/or intraocular lens (IOL) calculations and proposes a systematic approach for IOL selection in patients who have undergone laser corneal refractive surgery. RECENT FINDINGS: Corneal measurements and IOL calculations cannot be obtained accurately with the standard measuring technologies and formulas in patients with history of laser corneal refractive surgery; therefore a variety of methods and formulas, some of which required prerefractive surgery data, have been proposed to improve the accuracy of measurements and calculations...
January 2017: Current Opinion in Ophthalmology
Arjun B Sood, Matthew R Debiec, Steven Yeh, Hans E Grossniklaus, J Bradley Randleman
PURPOSE: The purpose of this study is to report a case of microsporidial endophthalmitis after penetrating keratoplasty in a healthy patient and discuss the management. METHODS: This is a case report. RESULTS: A 69-year-old healthy male underwent penetrating keratoplasty for corneal scar secondary to herpes stromal keratitis. He presented with features of acute graft rejection 3 years later. After failure of medical management, a repeat full thickness keratoplasty was performed...
December 2016: Journal of Ophthalmic Inflammation and Infection
J Bradley Randleman
No abstract text is available yet for this article.
July 1, 2016: Journal of Refractive Surgery
Abhijit Sinha Roy, Karol M Rocha, J Bradley Randleman, R Doyle Stulting, William J Dupps
No abstract text is available yet for this article.
April 2016: Experimental Eye Research
Meraf A Wolle, J Bradley Randleman, Maria A Woodward
No abstract text is available yet for this article.
2016: International Ophthalmology Clinics
Claudia Perez-Straziota, J Bradley Randleman
FS-assisted LASIK has become the preferred method for LASIK flap creation due to the precision, accuracy, and reproducibility of the flap creation. Thinner, planar flaps may help prevent cases of post-LASIK ectasia and may have a superior refractive outcome. However, FS flap creation has several unique complications that require early recognition and optimal timely management for the best visual outcomes.
2016: International Ophthalmology Clinics
Praneetha Thulasi, Sang Woo Kim, Rohit Shetty, J Bradley Randleman
PURPOSE: To report a case of recalcitrant epithelial ingrowth after small incision lenticule extraction (SMILE) treated successfully with a novel hydrogel ocular sealant. METHODS: Case report and literature review. RESULTS: A 32-year-old man who underwent small incision lenticule extraction (SMILE) complicated by difficult lenticule extraction developed visually significant epithelial ingrowth. He then underwent two flap lifts and epithelial scrapings and flap edge suturing with recurrence of epithelial ingrowth despite these interventions...
December 2015: Journal of Refractive Surgery
Praneetha Thulasi, Sumitra S Khandelwal, J Bradley Randleman
PURPOSE OF REVIEW: This article reviews current concepts in intraocular lens alignment strategies to maximize intraocular lens (IOL) positioning. RECENT FINDINGS: A variety of strategies has been developed to maximize toric IOL position, including preoperative calculators to determine the appropriate IOL power and orientation, intraoperative alignment devices, and postoperative software to determine if IOL rotation would be beneficial for refractive outcomes. SUMMARY: The combination of using multiple toric IOL calculators and intraoperative alignment devices has improved toric IOL outcomes...
January 2016: Current Opinion in Ophthalmology
J Bradley Randleman
No abstract text is available yet for this article.
October 2015: Journal of Refractive Surgery
Arthur Hammer, Sabine Kling, Marc-Olivier Boldi, Olivier Richoz, David Tabibian, J Bradley Randleman, Farhad Hafezi
PURPOSE: To establish corneal cross-linking (CXL) with riboflavin and UV-A in in the mouse cornea in vivo and to develop tools to measure the biomechanical changes observed. METHODS: A total of 55 male C57BL/6 wild-type mice (aged 5 weeks) were divided into 14 groups. Standard CXL parameters were adapted to the anatomy of the mouse cornea, and riboflavin concentration (0.1%-0.5%) and fluence series (0.09-5.4 J/cm²) were performed on the assumption of the endothelial damage thresholds...
October 2015: Investigative Ophthalmology & Visual Science
Marcony R Santhiago, David Smajda, Steven E Wilson, J Bradley Randleman
PURPOSE: To evaluate the contribution of flap thickness and ablation depth to the percentage of tissue altered (PTA) (flap thickness plus ablation depth divided by central corneal thickness) in determining the risk for ectasia after laser in situ keratomileusis (LASIK). SETTING: University of São Paulo, São Paulo, Brazil; Cleveland Clinic, Cleveland, Ohio, and Emory Vision at Emory University, Atlanta, Georgia, USA. DESIGN: Retrospective comparative study...
November 2015: Journal of Cataract and Refractive Surgery
J Bradley Randleman
No abstract text is available yet for this article.
June 2015: Journal of Cataract and Refractive Surgery
Cosimo Mazzotta, Farhad Hafezi, George Kymionis, Stefano Caragiuli, Soosan Jacob, Claudio Traversi, Stefano Barabino, J Bradley Randleman
In vivo confocal microscopy (IVCM) findings of 84 patients who had undergone conventional epithelium-off corneal collagen crosslinking (CXL) and accelerated CXL (ACXL) were retrospectively reviewed. Analysis confirmed that despite a significant decrease in the mean density of anterior keratocytes in the first 6 postoperative months, cell density after CXL and ACXL returned to baseline values at 12 months. The demarcation lines observed after treatments represent an expression of light-scattering (reflectivity changes) through different tissue densities...
October 2015: Ocular Surface
J Bradley Randleman, William J Dupps, Marcony R Santhiago, Yaron S Rabinowitz, Doug D Koch, R Doyle Stulting, Stephen D Klyce
No abstract text is available yet for this article.
August 2015: Cornea
J Bradley Randleman, Sumitra S Khandelwal, Farhad Hafezi
Since its inception in the late 1990s, corneal cross-linking has grown from an interesting concept to a primary treatment for corneal ectatic disease worldwide. Using a combination of ultraviolet-A light and a chromophore (vitamin B2, riboflavin), the cornea can be stiffened, usually with a single application, and progressive thinning diseases such as keratoconus arrested. Despite being in clinical use for many years, some of the underlying processes, such as the role of oxygen and the optimal treatment times, are still being worked out...
November 2015: Survey of Ophthalmology
Marcony R Santhiago, David Smadja, Steven E Wilson, Ronald R Krueger, Mario L R Monteiro, J Bradley Randleman
PURPOSE: To investigate the association of the percent tissue altered (PTA) with the occurrence of ectasia after LASIK in eyes with suspicious preoperative corneal topography. METHODS: This retrospective comparative case-control study compared associations of reported ectasia risk factors in 129 eyes, including 57 eyes with suspicious preoperative Placido-based corneal topography that developed ectasia after LASIK (suspect ectasia group), 32 eyes with suspicious topography that remained stable for at least 3 years after LASIK (suspect control group), and 30 eyes that developed ectasia with bilateral normal topography (normal topography ectasia group)...
April 2015: Journal of Refractive Surgery
J Bradley Randleman
No abstract text is available yet for this article.
April 2015: Journal of Refractive Surgery
Mohammed Ziaei, Allon Barsam, Neda Shamie, David Vroman, Terry Kim, Eric D Donnenfeld, Edward J Holland, John Kanellopoulos, Francis S Mah, J Bradley Randleman, Sheraz Daya, Jose Güell
UNLABELLED: Corneal ectasia is a progressive, degenerative, and noninflammatory thinning disorder of the cornea. Recently developed corneal reshaping techniques have expanded the treatment armamentarium available to the corneal specialist by offering effective nontransplant options. This review summarizes the current evidence base for corneal collagen crosslinking, topography-guided photorefractive keratectomy, and intrastromal corneal ring segment implantation for the treatment of corneal ectasia by analyzing the data published between the years 2000 and 2014...
April 2015: Journal of Cataract and Refractive Surgery
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