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https://www.readbyqxmd.com/read/29142415/are-polyunsaturated-fatty-acid-metabolites-the-protective-effect-of-4-hydroxytyrosol-on-human-red-blood-cell-membranes-and-oxidative-damage-4-hydroxyalkenals-compatible-in-hypertriglyceridemic-patients
#1
Giuseppe Gallo, Rosalinda Bruno, Adele Taranto, Guglielmo Martino
Background: Increased levels of malondialdehyde (MDA) and 4-hydroxynonenal (HNE) are demonstrated in plasma of uremic patients. A study showed that the comparison of erythrocytes of healthy and diseased patients (obese, hypertensive, and Type 2 diabetics) with age is associated to a disturbed oxidant/antioxidant balance when obesity is associated with hypertension. 4-hydroxytyrosol is shown to significantly protect red blood cells (RBCs) from oxidative damage (4-HNE). In literature, there are partial discussions on the role of lipids and their oxidation products...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29140679/a-green-approach-to-improving-the-strength-and-flame-retardancy-of-poly-vinyl-alcohol-clay-aerogels-incorporating-bio-based-gelatin
#2
Yu-Tao Wang, Hai-Bo Zhao, Kimberly C Degracia, Lin-Xuan Han, Hua Sun, Mingze Sun, Yu-Zhong Wang, David A Schiraldi
Bio-based gelatins were used to improve the compressive and flammability properties poly(vinyl alcohol)/montmorillonite (PVA/MMT) aerogels, fabricated using a simple and environmentally-friendly freeze-drying method. Due to the excellent compatibility and strong interfacial adhesion between PVA and gelatin, the compressive moduli of aerogels were enhanced dramatically with the incorporation of gelatin. PVA/MMT/porcine gelatin aerogels exhibit compressive modulus values as much as 12.4 MPa, nearly 300% that of the control PVA/MMT aerogel...
November 15, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29138908/amine-modified-magnetic-iron-oxide-nanoparticle-as-a-promising-carrier-for-application-in-bio-self-healing-concrete
#3
Mostafa Seifan, Alireza Ebrahiminezhad, Younes Ghasemi, Ali Khajeh Samani, Aydin Berenjian
Self-healing mechanisms are a promising solution to address the concrete cracking issue. Among the investigated self-healing strategies, the biotechnological approach is distinguished itself by inducing the most compatible material with concrete composition. In this method, the potent bacteria and nutrients are incorporated into the concrete matrix. Once cracking occurs, the bacteria will be activated, and the induced CaCO3 crystals will seal the concrete cracks. However, the effectiveness of a bio self-healing concrete strictly depends on the viability of bacteria...
November 14, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29134726/the-divergence-history-of-the-perennial-plant-linaria-cavanillesii-confirms-a-recent-loss-of-self-incompatibility
#4
Marie Voillemot, Quentin Rougemont, Camille Roux, John R Pannell
Many angiosperms prevent inbreeding through a self-incompatibility (SI) system, but the loss of SI has been frequent in their evolutionary history. The loss of SI may often lead to an increase in the selfing rate, with the purging of inbreeding depression and the ultimate evolution of a selfing syndrome, where plants have smaller flowers with reduced pollen and nectar production. In this study, we used approximate Bayesian computation (ABC) to estimate the timing of divergence between populations of the plant Linaria cavanillesii, whose populations differ in SI status and in which SI is associated with low inbreeding depression but not with a transition to full selfing or a selfing syndrome...
November 13, 2017: Journal of Evolutionary Biology
https://www.readbyqxmd.com/read/29123095/thermal-crumpling-of-perforated-two-dimensional-sheets
#5
David Yllanes, Sourav S Bhabesh, David R Nelson, Mark J Bowick
Thermalized elastic membranes without distant self-avoidance are believed to undergo a crumpling transition when the microscopic bending stiffness is comparable to kT, the scale of thermal fluctuations. Most potential physical realizations of such membranes have a bending stiffness well in excess of experimentally achievable temperatures and are therefore unlikely ever to access the crumpling regime. We propose a mechanism to tune the onset of the crumpling transition by altering the geometry and topology of the sheet itself...
November 9, 2017: Nature Communications
https://www.readbyqxmd.com/read/29118813/the-leukemic-stem-cell-niche-adaptation-to-hypoxia-versus-oncogene-addiction
#6
Giulia Cheloni, Martina Poteti, Silvia Bono, Erico Masala, Nathalie M Mazure, Elisabetta Rovida, Matteo Lulli, Persio Dello Sbarba
Previous studies based on low oxygen concentrations in the incubation atmosphere revealed that metabolic factors govern the maintenance of normal hematopoietic or leukemic stem cells (HSC and LSC). The physiological oxygen concentration in tissues ranges between 0.1 and 5.0%. Stem cell niches (SCN) are placed in tissue areas at the lower end of this range ("hypoxic" SCN), to which stem cells are metabolically adapted and where they are selectively hosted. The data reported here indicated that driver oncogenic proteins of several leukemias are suppressed following cell incubation at oxygen concentration compatible with SCN physiology...
2017: Stem Cells International
https://www.readbyqxmd.com/read/29114035/an-ultra-stable-single-chain-insulin-analog-resists-thermal-inactivation-and-exhibits-biological-signaling-duration-equivalent-to-the-native-protein
#7
Michael D Glidden, Khadijah Aldabbagh, Nelson B Phillips, Kelley Carr, Yen-Shan Chen, Jonathan Whittaker, Manijeh Phillips, Nalinda P Wickramasinghe, Nischay Rege, Mamuni Swain, Yi Peng, Yanwu Yang, Michael C Lawrence, Vivien C Yee, Faramarz Ismail-Beigi, Michael A Weiss
Thermal degradation of insulin complicates its delivery and use. Previous efforts to engineer ultra-stable analogs were confounded by prolonged cellular signaling in vivo, complicating mealtime therapy and of unclear safety. We therefore sought an ultra-stable analog whose potency and duration of action on intravenous bolus injection in diabetic rats are indistinguishable from wild-type (WT) insulin. Here, we describe the structure, function and stability of such an analog: a 57-residue single-chain insulin (SCI) with multiple acidic substitutions...
November 7, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29112055/self-selected-resistance-exercise-load-implications-for-research-and-prescription
#8
Sebastião Barbosa-Netto, Obanshe S dʼAcelino-E-Porto, Marcos B Almeida
Barbosa-Netto, S, d'Acelino-e-Porto, OS, and Almeida, MB. Self-selected resistance exercise load: implications for research and prescription. J Strength Cond Res XX(X): 000-000, 2017-Resistance training has been widely used for maintaining or improving the quality of life and sports performance. It is not clear, however, whether the load commonly used in these exercises is equivalent to the number of repetitions determined for execution, that is, the level of effort applied to the self-selected load. Ergo, the aim of this study was to identify the number of maximum repetitions that strength training practitioners can perform with the load commonly used (self-selected) to perform 10 repetitions in their training routines...
November 1, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29109766/cancer-nanomedicines-stabilized-by-%C3%AF-%C3%AF-stacking-between-heterodimeric-prodrugs-enable-exceptionally-high-drug-loading-capacity-and-safer-delivery-of-drug-combinations
#9
Hangxiang Wang, Jianmei Chen, Chang Xu, Linlin Shi, Munire Tayier, Jiahui Zhou, Jun Zhang, Jiaping Wu, Zhijian Ye, Tao Fang, Weidong Han
Combination therapy using distinct mode-of-action drugs has sparked a rapidly growing interest because this paradigm holds promise for improving the therapeutic efficacy of anticancer therapy. However, the current drug combination therapy refers to administering individual drugs together, which is far from a perfect regimen for cancer patients. The aim of this work was to demonstrate that synergistic delivery of two chemotherapeutic drugs in a single nanoparticle reservoir could be achieved through the rational chemical ligation of the drugs followed by supramolecular nano-assembly via blending of the drugs with a minimal amount of matrix...
2017: Theranostics
https://www.readbyqxmd.com/read/29105981/the-function-of-the-floral-corona-in-the-pollination-of-a-mediterranean-style-dimorphic-daffodil
#10
Rocío Pérez-Barrales, César A Abarca, Rocío Santos-Gally, Florian P Schiestl, Juan Arroyo
Narcissus papyraceus is a style dimorphic species with two floral forms, with anthers at similar height and stigmas above (long-styled L) and below (short-styled S) the anther level. The species is self-incompatible, but intra and inter-morph compatible. Populations are either dimorphic (including both morphs) in the region of the Strait of Gibraltar, or L-monomorphic (with only L plants) in the inland of the Iberian Peninsula. This variation correlates with the most common floral visitors, be these primarily long-tongued and short-tongued pollinators respectively, a rare condition in Mediterranean plants...
November 4, 2017: Plant Biology
https://www.readbyqxmd.com/read/29102221/-gender-meanings-of-the-risk-of-sexually-transmitted-infections-hiv-transmission-among-young-people
#11
Sílvia Saura, Víctor Jorquera, Dolors Rodríguez, Carina Mascort, Immaculada Castellà, Jordi García
AIM: To identify the links between social representations used by young people to construct their gender identity, sexuality, and the risk management for sexually transmitted infections. SETTING: Different settings of Primary Health Care in Girona. PARTICIPANTS: Young people aged between 16 and 21 years (32 participants) living in Girona. METHOD: A qualitative study with a social constructionist perspective. A theoretical sampling was carried out and the triangular group and individual interview techniques were used for data collection...
October 25, 2017: Atencion Primaria
https://www.readbyqxmd.com/read/29100170/validation-of-a-four-items-version-of-the-functional-remission-of-general-schizophrenia-scale-the-mini-frogs-to-capture-the-functional-benefits-of-clinical-remission
#12
J Mallet, S Lancrenon, P-M Llorca, C Lançon, F-J Baylé, P Gorwood
OBJECTIVES: We previously developed the Functional Remission Of General Schizophrenia (FROGS) scale demonstrating first, reliable assessment in a cross-sectional study and second, good time-stability. The purpose of the present analysis was to propose a shorter version (mini-FROGS), more compatible with the limited time available in a psychiatric visit, focusing on the functional domains that have higher likelihood of being improved with higher and/or longer symptomatic remission in different cultural backgrounds...
September 22, 2017: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/29099215/are-gravitational-waves-spinning-down-psr-j1023-0038
#13
B Haskell, A Patruno
The pulsar J1023+0038 rotates with a frequency ν≈592  Hz and has been observed to transition between a radio state, during which it is visible as a millisecond radio pulsar, and a low-mass x-ray binary (LMXB) state, during which accretion powered x-ray pulsations are visible. Timing during the two phases reveals that during the LMXB phase the neutron star is spinning down at a rate of ν[over ˙]≈-3×10^{-15}  Hz/s, which is approximately 27% faster than the rate measured during the radio phase, ν[over ˙]≈-2...
October 20, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29098113/hyperbaric-oxygen-therapy-and-oxygen-compatibility-of-skin-and-wound-care-products
#14
Stéphanie F Bernatchez, Joseph Tucker, Gwenael Chiffoleau
Objective: Use test methods to assess the oxygen compatibility of various wound care products. Approach: There are currently no standard test methods specifically for evaluating the oxygen compatibility and safety of materials under hyperbaric oxygen (HBO) conditions. However, tests such as the oxygen index (OI), oxygen exposure (OE), and autogenous ignition temperature (AIT) can provide useful information. Results: The OI test measures the minimum oxygen concentration that will support candle-like burning, and it was used to test 44 materials...
November 1, 2017: Advances in Wound Care
https://www.readbyqxmd.com/read/29096098/novel-agrochemical-conjugates-with-self-assembling-behaviour
#15
Qingtao Liu, Bim Graham, Adrian Hawley, Yao-Da Dong, Ben J Boyd
HYPOTHESIS: That conjugation of agrichemicals to pro-assembly hydrophobic moieties will enable enhanced compatibility and loading with host lyotropic liquid crystalline carrier matrix, and potentially self-assemble in their own right in aqueous environments. EXPERIMENTS: A series of lipid-like agrochemical-conjugates were synthesized using specific amphiphilic entities conjugated onto the agrochemicals, picloram and 2,4-dichlorophenoxyacetic acid (2,4-D). The self-assembly behaviour and compatibility of the novel entities when incorporated into phytantriol and monoolein-based liquid crystalline systems were examined using small angle X-ray scattering, cryo-TEM and polarized optical microscopy...
October 19, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29091452/validation-of-trimethylamine-n-oxide-tmao-force-fields-based-on-thermophysical-properties-of-aqueous-tmao-solutions
#16
Daniel Markthaler, Johannes Zeman, Jörg Baz, Jens Smiatek, Niels Hansen
Five molecular models for trimethylamine N-oxide (TMAO) to be used in conjunction with compatible models for liquid water are evaluated by comparison of molecular dynamics (MD) simulation results to experimental data as functions of TMAO molality. The experimental data comprise thermodynamic properties (density, apparent molar volume, and partial molar volume at infinite dilution), transport properties (self-diffusion and shear viscosity), structural properties (radial distribution functions and degree of hydrogen bonding), and dielectric properties (dielectric spectra and static permittivity)...
November 17, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29081055/peptide-lipidation-a-synthetic-strategy-to-afford-peptide-based-therapeutics
#17
Renata Kowalczyk, Paul W R Harris, Geoffrey M Williams, Sung-Hyun Yang, Margaret A Brimble
Peptide and protein aberrant lipidation patterns are often involved in many diseases including cancer and neurological disorders. Peptide lipidation is also a promising strategy to improve pharmacokinetic and pharmacodynamic profiles of peptide-based drugs. Self-adjuvanting peptide-based vaccines commonly utilise the powerful TLR2 agonist PamnCys lipid to stimulate adjuvant activity. The chemical synthesis of lipidated peptides can be challenging hence efficient, flexible and straightforward synthetic routes to access homogeneous lipid-tagged peptides are in high demand...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29079515/surface-adaptive-zwitterionic-nanoparticles-for-prolonged-blood-circulation-time-and-enhanced-cellular-uptake-in-tumor-cells
#18
Hanlin Ou, Tangjian Cheng, Yumin Zhang, Jinjian Liu, Yuxun Ding, Jingru Zhen, Wenzeng Shen, Yingjin Xu, Wenzeng Yang, Pei Niu, Jianfeng Liu, Yingli An, Yang Liu, Linqi Shi
Recently, zwitterionic materials have been developed as alternatives to PEG for prolonging the circulation time of nanoparticles without triggering immune responses. However, zwitterionic coatings also hindered the interactions between nanoparticles and tumor cells, leading to less efficient uptake of nanoparticles by cancer cells. Such effect significantly limited the applications of zwitterionic materials for the purposes of drug delivery and the development to novel therapeutic agents. To overcome these issues, surface-adaptive mixed-shell micelles (MSMs) with poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC)/poly(β-amino ester) (PAE) heterogeneous surfaces were constructed...
October 24, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29077809/linking-metabolic-network-features-to-phenotypes-using-sparse-group-lasso
#19
Satya Swarup Samal, Ovidiu Radulescu, Andreas Weber, Holger Fröhlich
Motivation: Integration of metabolic networks with '-omics' data has been a subject of recent research in order to better understand the behaviour of such networks with respect to differences between biological and clinical phenotypes. Under the conditions of steady state of the reaction network and the non-negativity of fluxes, metabolic networks can be algebraically decomposed into a set of sub-pathways often referred to as extreme currents (ECs). Our objective is to find the statistical association of such sub-pathways with given clinical outcomes, resulting in a particular instance of a self-contained gene set analysis method...
November 1, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29077792/unsupervised-multiple-kernel-learning-for-heterogeneous-data-integration
#20
Jérôme Mariette, Nathalie Villa-Vialaneix
Motivation: Recent high-throughput sequencing advances have expanded the breadth of available omics datasets and the integrated analysis of multiple datasets obtained on the same samples has allowed to gain important insights in a wide range of applications. However, the integration of various sources of information remains a challenge for systems biology since produced datasets are often of heterogeneous types, with the need of developing generic methods to take their different specificities into account...
October 25, 2017: Bioinformatics
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