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https://www.readbyqxmd.com/read/29785682/the-modified-memorial-symptom-assessment-scale-short-form-a-modified-response-format-and-rational-scoring-rules
#1
J L Sharp, K Gough, M C Pascoe, A Drosdowsky, V T Chang, P Schofield
PURPOSE: The Memorial Symptom Assessment Scale Short Form (MSAS-SF) is a widely used symptom assessment instrument. Patients who self-complete the MSAS-SF have difficulty following the two-part response format, resulting in incorrectly completed responses. We describe modifications to the response format to improve useability, and rational scoring rules for incorrectly completed items. METHODS: The modified MSAS-SF was completed by 311 women in our Peer and Nurse support Trial to Assist women in Gynaecological Oncology; the PeNTAGOn study...
May 21, 2018: Quality of Life Research
https://www.readbyqxmd.com/read/29783960/performance-of-oncoe6-cervical-test-with-collection-methods-enabling-self-sampling
#2
Amrei Krings, Anna M Dückelmann, Lutz Moser, Johannes Gollrad, Maarten Wiegerinck, Johannes Schweizer, Andreas M Kaufmann
BACKGROUND: The paradigm shift from cytological screening to Human Papillomavirus (HPV)-based screening for cervical cancer allows the introduction of new technologies in sample collection and diagnostics. The OncoE6™ Cervical Test (OncoE6 Test) is a rapid, easy-to-use lateral flow method detecting HPV16/18 E6 oncoproteins that has proven to detect high-grade cervical lesions with high specificity. If compatible with self-collection samples, this technology might allow for decentralized screening of hard-to-reach populations...
May 21, 2018: BMC Women's Health
https://www.readbyqxmd.com/read/29782546/chronic-use-of-psychotropic-medications-in-breastfeeding-women-is-it-safe
#3
Nirit Kronenfeld, Tomer Ziv Baran, Maya Berlin, Nour Karra, Natalie Dinavitser, Rana Cohen, Yifat Wiener, Eyal Schwartzberg, Matitiahu Bercovitch
BACKGROUND: Current knowledge regarding chronic use of psychotropic medications during breastfeeding is limited. The objective of this study was to evaluate the long-term effects of psychotropic monotherapy use during lactation on the breastfed infant. MATERIALS AND METHODS: In this prospective study, we followed 280 infants whose mothers contacted the Drug Consultation Center (DCC) at Assaf Harofeh Medical Center between January 2011 and December 2015, seeking information regarding the chronic use of psychotropic medications during lactation...
2018: PloS One
https://www.readbyqxmd.com/read/29781180/identifying-predictive-behavioral-markers-a-demonstration-using-automatically-reinforced-self-injurious-behavior
#4
Louis P Hagopian, Griffin W Rooker, Gayane Yenokyan
Predictive biomarkers (PBioMs) are objective biological measures that predict response to medical treatments for diseases. The current study translates methods used in the field of precision medicine to identify PBioMs to identify parallel predictive behavioral markers (PBMs), defined as objective behavioral measures that predict response to treatment. We demonstrate the utility of this approach by examining the accuracy of two PBMs for automatically reinforced self-injurious behavior (ASIB). Results of the analysis indicated both functioned as good to excellent PBMs...
May 21, 2018: Journal of Applied Behavior Analysis
https://www.readbyqxmd.com/read/29776653/accuracy-of-phase-contrast-velocity-mapping-proximal-and-distal-to-stent-artifact-during-cardiac-magnetic-resonance-imaging
#5
Catherine M Avitabile, Matthew A Harris, Ravi S Doddasomayajula, Steven G Chopski, Matthew J Gillespie, Yoav Dori, Andrew C Glatz, Mark A Fogel, Kevin K Whitehead
Little data are available on the accuracy of phase-contrast magnetic resonance imaging (PC-MRI) velocity mapping in the vicinity of intravascular metal stents other than nitinol stents. Therefore, we sought to determine this accuracy using in vitro experiments. An in vitro flow phantom was used with 3 stent types: (1) 316L stainless steel, (2) nitinol self-expanding, and (3) platinum-iridium. Steady and pulsatile flow was delivered with a magnetic resonance imaging-compatible pump (CardioFlow 5000, Shelley Medical, London, Ontario, Canada)...
April 20, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29776048/critical-neural-networks-with-short-and-long-term-plasticity
#6
L Michiels van Kessenich, M Luković, L de Arcangelis, H J Herrmann
In recent years self organized critical neuronal models have provided insights regarding the origin of the experimentally observed avalanching behavior of neuronal systems. It has been shown that dynamical synapses, as a form of short-term plasticity, can cause critical neuronal dynamics. Whereas long-term plasticity, such as Hebbian or activity dependent plasticity, have a crucial role in shaping the network structure and endowing neural systems with learning abilities. In this work we provide a model which combines both plasticity mechanisms, acting on two different time scales...
March 2018: Physical Review. E
https://www.readbyqxmd.com/read/29766450/metrical-congruency-and-kinematic-familiarity-facilitate-temporal-binding-between-musical-and-dance-rhythms
#7
Yi-Huang Su
Although music and dance are often experienced simultaneously, it is unclear what modulates their perceptual integration. This study investigated how two factors related to music-dance correspondences influenced audiovisual binding of their rhythms: the metrical match between the music and dance, and the kinematic familiarity of the dance movement. Participants watched a point-light figure dancing synchronously to a triple-meter rhythm that they heard in parallel, whereby the dance communicated a triple (congruent) or a duple (incongruent) visual meter...
May 15, 2018: Psychonomic Bulletin & Review
https://www.readbyqxmd.com/read/29755489/optimizing-production-in-the-new-generation-of-apricot-cultivars-self-incompatibility-s-rnase-allele-identification-and-incompatibility-group-assignment
#8
Sara Herrera, Jorge Lora, José I Hormaza, Maria Herrero, Javier Rodrigo
Apricot ( Prunus armeniaca L.) is a species of the Rosaceae that was originated in Central Asia, from where it entered Europe through Armenia. The release of an increasing number of new cultivars from different breeding programs is resulting in an important renewal of plant material worldwide. Although most traditional apricot cultivars in Europe are self-compatible, the use of self-incompatible cultivars as parental genotypes for breeding purposes is leading to the introduction of a number of new cultivars that behave as self-incompatible...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29754481/a-self-aligned-functionalization-approach-to-order-neuronal-networks-at-the-single-cell-level
#9
Adrien Casanova, Charline Blatché, Cecile Ferre, Hélène Martin, Daniel Gonzalez-Dunia, Liviu Nicu, Guilhem Larrieu
Despite significant progress, our knowledge of the functioning of the central nervous system still remains scarce to date. A better understanding of its behavior, in either normal or diseased conditions, goes through an increased knowledge of basic mechanisms involved in neuronal function, including at the single cell level. This has motivated significant efforts for the development of miniaturized sensing devices to monitor neuronal activity with high spatial and signal resolution. One of the main challenges remaining to be addressed in this domain is, however, the ability to create in vitro spatially-ordered neuronal networks at low density with a precise control of the cell location, to ensure proper monitoring of the activity of a defined set of neurons...
May 12, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29746772/direct-photolithography-on-molecular-crystals-for-high-performance-organic-optoelectronic-devices
#10
Yifan Yao, Lei Zhang, Tim Leydecker, Paolo Samorì
Organic crystals are generated via the bottom-up self-assembly of molecular building blocks which are held together through weak non-covalent interactions. Although they revealed extraordinary charge transport characteristics, their labile nature represents a major drawback towards their integration in opto-electronic devices when the use sophisticated patterning techniques is required. Here we have devised a radically new method to enable the use of photolithography directly on molecular crystals, with a spatial resolution below 300 nm, thereby allowing the precise wiring-up of multiple crystals on demand...
May 10, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29744843/biogelx-cell-culture-on-self-assembling-peptide-gels
#11
Mhairi M Harper, Michael L Connolly, Laura Goldie, Eleanore J Irvine, Joshua E Shaw, Vineetha Jayawarna, Stephen M Richardson, Matthew J Dalby, David Lightbody, Rein V Ulijn
Aromatic peptide amphiphiles can form self-supporting nanostructured hydrogels with tunable mechanical properties and chemical compositions. These hydrogels are increasingly applied in two-dimensional (2D) and three-dimensional (3D) cell culture, where there is a rapidly growing need to store, grow, proliferate, and manipulate naturally derived cells within a hydrated, 3D matrix. Biogelx Limited is a biomaterials company, created to commercialize these bio-inspired hydrogels to cell biologists for a range of cell culture applications...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29734356/microbiota-epitope-similarity-either-dampens-or-enhances-the-immunogenicity-of-disease-associated-antigenic-epitopes
#12
Sebastian Carrasco Pro, Cecilia S Lindestam Arlehamn, Sandeep K Dhanda, Chelsea Carpenter, Mikaela Lindvall, Ali A Faruqi, Clark A Santee, Harald Renz, John Sidney, Bjoern Peters, Alessandro Sette
The microbiome influences adaptive immunity and molecular mimicry influences T cell reactivity. Here, we evaluated whether the sequence similarity of various antigens to the microbiota dampens or increases immunogenicity of T cell epitopes. Sets of epitopes and control sequences derived from 38 antigenic categories (infectious pathogens, allergens, autoantigens) were retrieved from the Immune Epitope Database (IEDB). Their similarity to microbiome sequences was calculated using the BLOSUM62 matrix. We found that sequence similarity was associated with either dampened (tolerogenic; e...
2018: PloS One
https://www.readbyqxmd.com/read/29728676/genetics-of-distyly-and-homostyly-in-a-self-compatible-primula
#13
Shuai Yuan, Spencer C H Barrett, Cehong Li, Xiaojie Li, Kongping Xie, Dianxiang Zhang
The transition from outcrossing to selfing through the breakdown of distyly to homostyly has occurred repeatedly among families of flowering plants. Homostyles can originate by major gene changes at the S-locus linkage group, or by unlinked polygenic modifiers. Here, we investigate the inheritance of distyly and homostyly in Primula oreodoxa, a subalpine herb endemic to Sichuan, China. Controlled self- and cross-pollinations confirmed that P. oreodoxa unlike most heterostylous species is fully self-compatible...
May 4, 2018: Heredity
https://www.readbyqxmd.com/read/29726256/all-organic-high-performance-piezoelectric-nanogenerator-with-multilayer-assembled-electrospun-nanofibers-mats-for-self-powered-multifunctional-sensor
#14
Kuntal Maity, Dipankar Mandal
Rapid development of wearable electronics, piezoelectric nanogenerator (PNG) has been paid a special attention due to its sustainable and accessible energy generation. In this context, we present a simple yet highly efficient design strategy to enhance the output performance of an all organic PNG (OPNG) based on multilayer assembled electrospun poly(vinyledine fluoride) (PVDF) nanofibers (NFs) mats where vapor phase polymerized poly(3,4- ethylenedioxythiphene) (PEDOT) coated PVDF NFs are assembled as electrodes and neat PVDF NFs is utilized as an active component...
May 4, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29725066/isothermal-folding-of-a-light-up-bio-orthogonal-rna-origami-nanoribbon
#15
Emanuela Torelli, Jerzy Wieslaw Kozyra, Jing-Ying Gu, Ulrich Stimming, Luca Piantanida, Kislon Voïtchovsky, Natalio Krasnogor
RNA presents intringuing roles in many cellular processes and its versatility underpins many different applications in synthetic biology. Nonetheless, RNA origami as a method for nanofabrication is not yet fully explored and the majority of RNA nanostructures are based on natural pre-folded RNA. Here we describe a biologically inert and uniquely addressable RNA origami scaffold that self-assembles into a nanoribbon by seven staple strands. An algorithm is applied to generate a synthetic De Bruijn scaffold sequence that is characterized by the lack of biologically active sites and repetitions larger than a predetermined design parameter...
May 3, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29721565/capturing-the-effect-of-pf-3-c-2-f-5-3-vs-pf-6-flexible-anion-vs-rigid-and-scaled-charge-vs-unit-on-the-transport-properties-of-bmim-based-ionic-liquids-a-comparative-md-study
#16
Mohammad H Kowsari, Soraya Ebrahimi
Comprehensive molecular dynamics simulations are performed to study the average single-particle dynamics and the transport properties of 1-butyl-3-methylimidazolium hexafluorophosphate, [bmim][PF6], and 1-butyl-3-methylimidazolium tris(pentafluoroethyl)trifluorophosphate, [bmim][FAP], ionic liquids (ILs) at 400 K. We applied one of the most widely used nonpolarizable all-atom force fields for ILs, both with the original unit (±1) charges on each ion and with the partial charges uniformly scaled to 80-85%, taking into account the average polarizability and tracing the experimentally compatible transport properties...
May 3, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29718197/-pin-ing-down-the-mechanism-of-prion-appearance
#17
Tricia R Serio
Prions are conformationally flexible proteins capable of adopting a native state and a spectrum of alternative states associated with a change in the function of the protein. These alternative states are prone to assemble into amyloid aggregates, which provide a structure for self-replication and transmission of the underlying conformer and thereby the emergence of a new phenotype. Amyloid appearance is a rare event in vivo, regulated by both the aggregation propensity of prion proteins and their cellular environment...
May 1, 2018: FEMS Yeast Research
https://www.readbyqxmd.com/read/29717521/evolution-of-interspecies-unilateral-incompatibility-in-the-relatives-of-arabidopsis-thaliana
#18
Ling Li, Bo Liu, Xiaomei Deng, Hainan Zhao, Hongyan Li, Shilai Xing, Della D Fetzer, Mengya Li, Mikhail E Nasrallah, June B Nasrallah, Pei Liu
The evolutionary concurrence of intraspecies self-incompatibility (SI) and explosive angiosperm radiation in the Cretaceous has led to the hypothesis that SI was one of the predominant drivers of rapid speciation in angiosperms. Interspecies unilateral incompatibility (UI) usually occurs when pollen from a self-compatible (SC) species is rejected by the pistils of a SI species, while the reciprocal pollination is compatible (UC). Although this SI x SC type UI is most prevalent and viewed as a prezygotic isolation barrier to promote incipient speciation of angiosperms, comparative evidence to support such a role is lacking...
May 1, 2018: Molecular Ecology
https://www.readbyqxmd.com/read/29716955/evolutionary-pathways-for-the-generation-of-new-self-incompatibility-haplotypes-in-a-non-self-recognition-system
#19
Katarína Boďová, Tadeas Priklopil, David L Field, Nicholas H Barton, Melinda Pickup
Self-incompatibility (SI) is a genetically based recognition system that functions to prevent self-fertilization and mating among related plants. An enduring puzzle in SI is how the high diversity observed in nature arises and is maintained. Based on the underlying recognition mechanism, SI can be classified into two main groups: self- and non-self recognition. Most work has focused on diversification within self-recognition systems despite expected differences between the two groups in the evolutionary pathways and outcomes of diversification...
April 30, 2018: Genetics
https://www.readbyqxmd.com/read/29713031/amino-acid-encoded-biocatalytic-self-assembly-enables-the-formation-of-transient-conducting-nanostructures
#20
Mohit Kumar, Nicole L Ing, Vishal Narang, Nadeesha K Wijerathne, Allon I Hochbaum, Rein V Ulijn
Aqueous compatible supramolecular materials hold promise for applications in environmental remediation, energy harvesting and biomedicine. One remaining challenge is to actively select a target structure from a multitude of possible options, in response to chemical signals, while maintaining constant, physiological conditions. Here, we demonstrate the use of amino acids to actively decorate a self-assembling core molecule in situ, thereby controlling its amphiphilicity and consequent mode of assembly. The core molecule is the organic semiconductor naphthalene diimide, functionalized with D- and L- tyrosine methyl esters as competing reactive sites...
April 30, 2018: Nature Chemistry
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