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https://www.readbyqxmd.com/read/28548045/3d-liver-membrane-system-by-co-culturing-human-hepatocytes-sinusoidal-endothelial-and-stellate-cells
#1
Haysam Mohamed Magdy Ahmed, Simona Salerno, Sabrina Morelli, Lidetta Giorno, Loredana De Bartolo
In this study, a designed approach has been utilized for the development of a 3D liver system. This approach makes use of primary human sinusoidal endothelial cells, stellate cells and hepatocytes that are seeded sequentially on hollow fiber membranes (HF) in order to mimic the layers of cells found in vivo. To this purpose modified polyethersulfone (PES) HF membranes were used for the creation of a 3D human liver system in static and dynamic conditions. In order to verify the positive effect of non-parenchymal cells on the maintenance of hepatocyte viability and functions, homotypic cultures of hepatocytes alone on the HF membranes were further investigated...
May 26, 2017: Biofabrication
https://www.readbyqxmd.com/read/28547994/self-assembled-molecular-nanowires-for-high-performance-organic-transistors
#2
Luke R Fleet, James E Stott, Byron Villis, Salahud Din, Michele Serri, Gabriel Aeppli, Sandrine Heutz, Arokia Nathan
While organic semiconductors provide tantalising possibilities for low-cost, light-weight, flexible electronic devices, their current use in transistors - the fundamental building block - is rather limited as their speed and reliability is not competitive with their inorganic counterparts, and is simply too poor for many practical applications. Through self-assembly, highly ordered nanostructures can be prepared that have more competitive transport characteristics, but no simple, scalable method has been discovered that can produce devices based on such nanostructures...
May 26, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28544154/floral-nectar-of-the-obligate-outcrossing-canavalia-gladiata-jacq-dc-fabaceae-contains-only-one-predominant-protein-a-class-iii-acidic-chitinase
#3
Xue-Long Ma, Richard I Milne, Hong-Xia Zhou, Jiang-Yu Fang, Hong-Guang Zha
Floral nectar can affect the fitness of insect-pollinated plants, through both attraction and manipulation of pollinators. Self-incompatible insect-pollinated plants receive more insect visits than their self-compatible relatives, and the nectar of such species might face more risk to be infested by the pathogens carried by pollinators than self-compatible plants. Proteins in nectar (nectarins) play an important role in the protection of nectar, but little is known regarding nectarins in self-incompatible species...
May 20, 2017: Plant Biology
https://www.readbyqxmd.com/read/28539141/individual-traits-personal-values-and-conflict-resolution-in-an-isolated-confined-extreme-environment
#4
Jesper G Corneliussen, Gloria R Leon, Anders Kjærgaard, Birgit A Fink, Noah C Venables
BACKGROUND: The study of personality traits, personal values, and the emergence of conflicts within groups performing in an isolated, confined, and extreme environment (ICE) may provide insights helpful for the composition and support of space crews for long duration missions. METHODS: Studied pre/post and over the 2-yr period of the investigation were 10 Danish military personnel deployed to stations in Greenland on a 26-mo staggered rotation. Subjects completed the NEO PI-R, Triarchic Psychopathy Measure, and Portrait Values Questionnaire, and participated in structured interviews...
June 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28533751/docetaxel-loaded-nanoparticles-assembled-from-%C3%AE-cyclodextrin-calixarene-giant-surfactants-physicochemical-properties-and-cytotoxic-effect-in-prostate-cancer-and-glioblastoma-cells
#5
Laura Gallego-Yerga, Inmaculada Posadas, Cristina de la Torre, Jesús Ruiz-Almansa, Francesco Sansone, Carmen Ortiz Mellet, Alessandro Casnati, José M García Fernández, Valentín Ceña
Giant amphiphiles encompassing a hydrophilic β-cyclodextrin (βCD) component and a hydrophobic calix[4]arene (CA4) module undergo self-assembly in aqueous media to afford core-shell nanospheres or nanocapsules, depending on the nanoprecipitation protocol, with high docetaxel (DTX) loading capacity. The blank and loaded nanoparticles have been fully characterized by dynamic light scattering (DLS), ζ-potential measurements and cryo-transmission electron microscopy (cryo-TEM). The data are compatible with the distribution of the drug between the nanoparticle core and the shell, where it is probably anchored by inclusion of the DTX aromatic moieties in βCD cavities...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28522638/a-self-consistent-structural-perturbation-approach-for-determining-the-magnitude-and-extent-of-allosteric-coupling-in-proteins
#6
Nandakumar Rajasekaran, Athi N Naganathan
Elucidating the extent of energetic coupling between residues in single-domain proteins, a fundamental determinant of allostery, information transfer and folding cooperativity, has remained a grand challenge. While several sequence- and structure-based approaches have been proposed, a self-consistent description that is simultaneously compatible with unfolding thermodynamics is lacking. We had recently developed a simple structural perturbation protocol that captures the changes in thermodynamic stabilities induced by point mutations within the protein interior...
May 18, 2017: Biochemical Journal
https://www.readbyqxmd.com/read/28521729/self-rated-health-and-functional-capacity-in-individuals-reporting-overlapping-symptoms-of-gastroesophageal-reflux-disease-functional-dyspepsia-and-irritable-bowel-syndrome-a-population-based-study
#7
Dorte Ejg Jarbøl, Sanne Rasmussen, Kirubakaran Balasubramaniam, Sandra Elnegaard, Peter Fentz Haastrup
BACKGROUND: Gastroesophageal reflux disease (GERD), functional dyspepsia (FD) and irritable bowel syndrome (IBS) are common functional gastrointestinal conditions with a significant impact on daily life. The objectives were to analyse general self-rated health and self-reported functional capacity in adults meeting the criteria for GERD, FD and IBS, respectively, and in individuals who meet the criteria for more than one of the conditions. METHODS: A nationwide study of 100,000 individuals aged 20 years and above, randomly selected in the general Danish population...
May 18, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/28521103/organic-inorganic-hybrid-perovskite-nanowire-laser-arrays
#8
Peng Liu, Xianxiong He, Jiahuan Ren, Qing Liao, Jiannian Yao, Hongbing Fu
Fabrication of semiconductor nanowire laser arrays with multi-color outputs are very challenging, owing to difficulties in direct monolithic growth and patterning of III-V semiconductors on silicon substrates. Recently, methylammonium lead halide perovskites (MAPbX3, X = Cl, Br, I) have emerged as an important class of high-performance solution-processed optoelectronic materials. Here, we combined the 'top-down' fabricated polydimethylsiloxane (PDMS) rectangular groove-template (RGT) with the 'bottom-up' solution self-assembly together to prepare large-scale perovskite nanowire (PNW) arrays...
May 18, 2017: ACS Nano
https://www.readbyqxmd.com/read/28513120/gestational-weight-gain-and-its-relationship-with-maternal-characteristics
#9
Yeela Borenstein Ben Naftali, Ido Solt, Lior Lowenstein, Irit Chermesh
BACKGROUND: Both high and insufficient weight gain during pregnancy have been associated with adverse outcomes for mothers and their offspring. OBJECTIVES: To describe self-reported weight gain during pregnancy, assess the concurrence of this weight gain with issued recommendations, and investigate associations between lifestyle factors and weight gain. METHODS: In this cross-sectional study, 109 pregnant women hospitalized in one gynecological and obstetrics department completed questionnaires related to weight gain and lifestyle factors such as smoking, diet and exercise...
May 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28507920/passenger-lymphocyte-syndrome-pls-a-single-center-retrospective-analysis-of-minor-abo-incompatible-liver-transplants
#10
Sévérine de Bruijn, Ester Philipse, Marie Madeleine Couttenye, Bart Bracke, Dirk Ysebaert, Peter Michielsen, Sven Francque, Thomas Vanwolleghem, Anke Verlinden
Background and Aims: Due to the shortage of donor livers, minor ABO-incompatible liver transplantations are commonly performed. Together with the allograft, immunocompetent B-lymphocytes, called passenger lymphocytes, are transplanted. In case of minor ABO-incompatibility, these passenger lymphocytes produce antibodies directed towards the recipient's red blood cells, which causes immune-mediated hemolysis, also known as the passenger lymphocyte syndrome (PLS). Although this is a self-limiting disorder, serious complications can occur, including graft failure...
March 28, 2017: Journal of Clinical and Translational Hepatology
https://www.readbyqxmd.com/read/28504871/pollination-and-breeding-system-of-the-enigmatic-south-african-parasitic-plant-mystropetalon-thomii-mystropetalaceae-rodents-welcome-but-not-needed
#11
Nina Hobbhahn, Sandy-Lynn Steenhuisen, Toni Olsen, Jeremy J Midgley, Steven D Johnson
Unrelated plants adapted to particular pollinator types tend to exhibit convergent evolution in floral traits. However, inferences about likely pollinators from "pollination syndromes" can be problematic due to trait overlap among some syndromes and unusual floral architecture in some lineages. An example is the rare South African parasitic plant Mystropetalon thomii (Mystropetalaceae), which has highly unusual brush-like inflorescences that exhibit features of both bird- and rodent-pollination syndromes. We used camera traps to record flower visitors, quantified floral spectral reflectance and nectar and scent production, experimentally determined self-compatibility and breeding system, and studied pollen dispersal using fluorescent dyes...
May 15, 2017: Plant Biology
https://www.readbyqxmd.com/read/28489095/metrology-of-dna-arrays-by-super-resolution-microscopy
#12
Christopher M Green, Kelly Schutt, Noah Morris, Reza M Zadegan, William L Hughes, Wan Kuang, Elton Graugnard
Recent results in the assembly of DNA into structures and arrays with nanoscale features and patterns have opened the possibility of using DNA for sub-10 nm lithographic patterning of semiconductor devices. Super-resolution microscopy is being actively developed for DNA-based imaging and is compatible with inline optical metrology techniques for high volume manufacturing. Here, we combine DNA tile assembly with state-dependent super-resolution microscopy to introduce crystal-PAINT as a novel approach for metrology of DNA arrays...
May 10, 2017: Nanoscale
https://www.readbyqxmd.com/read/28488872/luminescent-organic-semiconducting-langmuir-monolayers
#13
Elena V Agina, Artur A Mannanov, Alexey S Sizov, Olga Vechter, Oleg V Borshchev, Artem V Bakirov, Maxim Anatolievich Shcherbina, Sergei N Chvalun, Vladislav G Konstantinov, Vladimir Vasilievich Bruevich, Oleg V Kozlov, Maxim S Pshenichnikov, Dmitry Yurievich Paraschuk, Sergei A Ponomarenko
In recent years, monolayer organic field-effect devices such as transistors and sensors have demonstrated their high potential. In contrast, monolayer electroluminescent organic field-effect devices are still in their infancy. One of the key challenges here is to create such organic material that self-organizes in a monolayer and combines efficient charge transport with luminescence. Herein, we report a novel organosilicon derivative of oligothiophene-phenylene dimer D2-Und-PTTP-TMS (D2: tetramethyldisiloxane, Und: undecylenic spacer, P: 1,4-phenylene, T: 2,5-thiophene, TMS: trimethylsilyl) that meets these requirements...
May 10, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28487671/improved-mental-acuity-forecasting-with-an-individualized-quantitative-sleep-model
#14
Brent D Winslow, Nam Nguyen, Kimberly E Venta
Sleep impairment significantly alters human brain structure and cognitive function, but available evidence suggests that adults in developed nations are sleeping less. A growing body of research has sought to use sleep to forecast cognitive performance by modeling the relationship between the two, but has generally focused on vigilance rather than other cognitive constructs affected by sleep, such as reaction time, executive function, and working memory. Previous modeling efforts have also utilized subjective, self-reported sleep durations and were restricted to laboratory environments...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28484355/the-students-viewpoint-on-quality-of-educational-services-in-iran
#15
Hasan Siamian, Farideh Rostami, Aliasghar Nadi Ghara, Ghassem Abedi
BACKGROUND: Recently, focusing on higher education quality has got increasingly critical. The novel managerial attitudes have defined the customer-demanded quality. Based on this, recognizing the receivers' perception of the quality of the services offered and evaluating the quality of the service is considered of the basic measures taken in order to develop quality promotion programs. Therefore, this is a qualitative research conducted for students' viewpoint on quality of educational services...
March 2017: Materia Socio-medica
https://www.readbyqxmd.com/read/28478987/comparative-evaluation-of-3-microbond-strength-tests-using-4-adhesive-systems-mechanical-finite-element-and-failure-analysis
#16
Roberto E Campos, Paulo César F Santos Filho, Osmir Batista de O Júnior, Gláucia M B Ambrosano, Cristina Alves Pereira
STATEMENT OF PROBLEM: Bond strength (BS) values from in vitro studies are useful when dentists are selecting an adhesive system, but there is no ideal measuring method. PURPOSE: The purpose of this in vitro study was to investigate the influence of the evaluation method in the BS between dentin and composite resin. MATERIAL AND METHODS: Molars with exposed superficial dentin (N=240) were divided into 3 groups according to the test: microtensile (μTBS), microshear (μSBS), and micropush-out (μPBS)...
May 5, 2017: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/28473793/time-frame-affects-vantage-point-in-episodic-and-semantic-autobiographical-memory-evidence-from-response-latencies
#17
Jerzy J Karylowski, Blazej Mrozinski
Previous research suggests that, with the passage of time, representations of self in episodic memory become less dependent on their initial (internal) vantage point and shift toward an external perspective that is normally characteristic of how other people are represented. The present experiment examined this phenomenon in both episodic and semantic autobiographical memory using latency of self-judgments as a measure of accessibility of the internal vs. the external perspective. Results confirmed that in the case of representations of the self retrieved from recent autobiographical memories, trait-judgments regarding unobservable self-aspects (internal perspective) were faster than trait judgments regarding observable self-aspects (external perspective)...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28472950/senescence-associated-il-6-and-il-8-cytokines-induce-a-self-and-cross-reinforced-senescence-inflammatory-milieu-strengthening-tumorigenic-capabilities-in-the-mcf-7-breast-cancer-cell-line
#18
Paola Ortiz-Montero, Arturo Londoño-Vallejo, Jean-Paul Vernot
BACKGROUND: There is compelling evidence associating senescent cells with the malignant progression of tumours. Of all senescence-related mechanisms, the so-called senescence-associated secretory phenotype (SASP) has attracted much attention. Since the pro-inflammatory cytokines IL-6 and IL-8 are consistently present in the SASP, and secreted by highly aggressive breast cancer cell lines, we aimed at elucidating their role on the less aggressive breast cancer cell line MCF-7, which does not secret these cytokines...
May 4, 2017: Cell Communication and Signaling: CCS
https://www.readbyqxmd.com/read/28470578/acute-hemorrhagic-edema-of-infancy-the-experience-of-a-large-tertiary-pediatric-center-in-israel
#19
Limor Parker, Keren Shahar-Nissan, Liat Ashkenazi-Hoffnung, Liora Harel, Jacob Amir, Omer Trivizki, Efraim Bilavsky
BACKGROUND: Acute hemorrhagic edema of infancy (AHEI) is a rare leukocytoclastic vasculitis of the small vessels occurring at a young age and considered as a benign self-limited disease. Due to its low prevalence, there are limited data on the presentation and complications of this disease. METHODS: All computerized files of children who were hospitalized at a tertiary pediatric center due to AHEI over a 10 year period were reviewed. Clinical, laboratory and histopathological data were collected...
April 29, 2017: World Journal of Pediatrics: WJP
https://www.readbyqxmd.com/read/28465802/comparing-maternal-breastfeeding-self-efficacy-during-first-week-and-sixth-week-postpartum
#20
Sedighe Pakseresht, Farzane Pourshaban, Zahra Bostani Khalesi
INTRODUCTION: The ideal nourishment for the first 12 months of a child's life comes from breastfeeding its mother's milk, and maternal self-efficacy is one factor which affects breastfeeding duration. Therefore, the present study aimed to compare the maternal breastfeeding self-efficacy during the first week and sixth-week postpartum. METHODS: This descriptive, analytical study was conducted on 767 women referring to the Family Health Research Center of Rasht in 2014...
February 2017: Electronic Physician
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