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JOURNAL ARTICLE
Muhammad B Khalid, Ellen Zektser, Eric Chu, Min Li, Joanna Utoh, Patrick Ryan, Hanna S Loving, Roa Harb, Robbie Kattappuram, Lindsay Chatman, Stella Hartono, Estefania Claudio-Etienne, Guangping Sun, Edward P Feener, Zhongbo Li, Samuel K Lai, Quang Le, Lawrence B Schwartz, Jonathan J Lyons, Hirsh Komarow, Zhao-Hua Zhou, Haniya Raza, Maryland Pao, Karen Laky, Steven M Holland, Erica Brittain, Pamela A Frischmeyer-Guerrerio
BACKGROUND: Systemic allergic reactions (sARs) following coronavirus disease-2019 (COVID-19) mRNA vaccines were initially reported at a higher rate than traditional vaccines. OBJECTIVE: We aimed to evaluate the safety of revaccination in these individuals and to interrogate mechanisms underlying these reactions. METHODS: In this randomized, double-blinded, phase 2 trial, individuals 16-69 years who previously reported a convincing sAR to their first dose of COVID-19 mRNA vaccine were randomly assigned to receive second dose of BNT162b2 (Pfizer-BioNTech; Comirnaty®) vaccine and placebo on consecutive days in a blinded, 1:1 cross-over fashion at the National Institutes of Health (NIH)...
March 7, 2024: Journal of Allergy and Clinical Immunology
#2
RANDOMIZED CONTROLLED TRIAL
Edward Holland, Paul Karpecki, Murray Fingeret, Jack Schaeffer, Preeya Gupta, Nicole Fram, Gerard Smits, Teresa Ignacio, Richard Lindstrom
PURPOSE: This study was undertaken to evaluate the safety and efficacy of CSF-1 (0.4% pilocarpine hydrochloride ophthalmic solution) for use in individuals with presbyopia. METHODS: Two Phase 3 multicenter, randomized, double-masked, vehicle-controlled, parallel-group clinical trials were conducted in 35 private ophthalmology clinics in the United States from October 2020 to February 2022. Key inclusion criteria were the following: (1) age 45-64 years, (2) distance-corrected near visual acuity (DCNVA) at 40 cm ≥0...
February 2024: Clinical Therapeutics
#3
JOURNAL ARTICLE
R Donald Harvey, Therica M Miller, Patricia A Hurley, Ramya Thota, Lora J Black, Suanna S Bruinooge, Leigh M Boehmer, Mark E Fleury, Jasmine Kamboj, Mujahid A Rizvi, Banu E Symington, William D Tap, David M Waterhouse, Laura A Levit, Janette K Merrill, Sheila A Prindiville, Teri Pollastro, Jamie R Brewer, Leslie P Byatt, Leila Hamroun, Edward S Kim, Nicole Holland, Grzegorz S Nowakowski
No abstract text is available yet for this article.
January 9, 2024: Cancer
#4
JOURNAL ARTICLE
Edward L Hannan, Yifeng Wu, Lamia Harik, Jacqueline Tamis-Holland, Alice K Jacobs, Joanna Chikwe, Kimberly S Cozzens, Mario Gaudino
OBJECTIVE: To compare outcomes in women undergoing percutaneous coronary intervention (PCI) and coronary artery bypass graft (CABG) surgery. DESIGN: This retrospective, propensity-score matched cohort study from the New York State cardiac registry (2012-2018) included all women with multivessel coronary artery disease undergoing PCI with everolimus-eluting stents (EES) and CABG surgery. The primary outcome was all-cause mortality. The key secondary outcome was major adverse cardiac events, defined as the composite of all-cause mortality, myocardial infarction, and stroke...
December 14, 2023: Journal of Thoracic and Cardiovascular Surgery
#5
JOURNAL ARTICLE
Rebecca R Chamley, Jennifer L Holland, Jonathan Collins, Kayleigh Pierce, William D Watson, Peregrine G Green, David O'Brien, Oliver O'Sullivan, Robert Barker-Davies, Peter Ladlow, Stefan Neubauer, Alexander Bennett, Edward D Nicol, David A Holdsworth, Oliver J Rider
BACKGROUND: Since the COVID-19 pandemic, post-COVID syndrome (persistent symptoms/complications lasting >12 weeks) continues to pose medical and economic challenges. In military personnel, where optimal fitness is crucial, prolonged limitations affecting their ability to perform duties has occupational and psychological implications, impacting deployability and retention. Research investigating post-COVID syndrome exercise capacity and cardiopulmonary effects in military personnel is limited...
November 17, 2023: International Journal of Cardiology
#6
JOURNAL ARTICLE
Alistair T Pagnamenta, Carme Camps, Edoardo Giacopuzzi, John M Taylor, Mona Hashim, Eduardo Calpena, Pamela J Kaisaki, Akiko Hashimoto, Jing Yu, Edward Sanders, Ron Schwessinger, Jim R Hughes, Gerton Lunter, Helene Dreau, Matteo Ferla, Lukas Lange, Yesim Kesim, Vassilis Ragoussis, Dimitrios V Vavoulis, Holger Allroggen, Olaf Ansorge, Christian Babbs, Siddharth Banka, Benito Baños-Piñero, David Beeson, Tal Ben-Ami, David L Bennett, Celeste Bento, Edward Blair, Charlotte Brasch-Andersen, Katherine R Bull, Holger Cario, Deirdre Cilliers, Valerio Conti, E Graham Davies, Fatima Dhalla, Beatriz Diez Dacal, Yin Dong, James E Dunford, Renzo Guerrini, Adrian L Harris, Jane Hartley, Georg Hollander, Kassim Javaid, Maureen Kane, Deirdre Kelly, Dominic Kelly, Samantha J L Knight, Alexandra Y Kreins, Erika M Kvikstad, Craig B Langman, Tracy Lester, Kate E Lines, Simon R Lord, Xin Lu, Sahar Mansour, Adnan Manzur, Reza Maroofian, Brian Marsden, Joanne Mason, Simon J McGowan, Davide Mei, Hana Mlcochova, Yoshiko Murakami, Andrea H Németh, Steven Okoli, Elizabeth Ormondroyd, Lilian Bomme Ousager, Jacqueline Palace, Smita Y Patel, Melissa M Pentony, Chris Pugh, Aboulfazl Rad, Archana Ramesh, Simone G Riva, Irene Roberts, Noémi Roy, Outi Salminen, Kyleen D Schilling, Caroline Scott, Arjune Sen, Conrad Smith, Mark Stevenson, Rajesh V Thakker, Stephen R F Twigg, Holm H Uhlig, Richard van Wijk, Barbara Vona, Steven Wall, Jing Wang, Hugh Watkins, Jaroslav Zak, Anna H Schuh, Usha Kini, Andrew O M Wilkie, Niko Popitsch, Jenny C Taylor
BACKGROUND: Whole genome sequencing is increasingly being used for the diagnosis of patients with rare diseases. However, the diagnostic yields of many studies, particularly those conducted in a healthcare setting, are often disappointingly low, at 25-30%. This is in part because although entire genomes are sequenced, analysis is often confined to in silico gene panels or coding regions of the genome. METHODS: We undertook WGS on a cohort of 122 unrelated rare disease patients and their relatives (300 genomes) who had been pre-screened by gene panels or arrays...
November 9, 2023: Genome Medicine
#7
JOURNAL ARTICLE
#8
JOURNAL ARTICLE
Dayane Cristina Lima, Alejandro Castro Aviles, Ryan Timothy Alpers, Alden Perkins, Dylan L Schoemaker, Martin Costa, Kathryn J Michel, Shawn Kaeppler, David Ertl, Maria Cinta Romay, Joseph L Gage, James Holland, Timothy Beissinger, Martin Bohn, Edward Buckler, Jode Edwards, Sherry Flint-Garcia, Michael A Gore, Candice N Hirsch, Joseph E Knoll, John McKay, Richard Minyo, Seth C Murray, James Schnable, Rajandeep S Sekhon, Maninder P Singh, Erin E Sparks, Peter Thomison, Addie Thompson, Mitchell Tuinstra, Jason Wallace, Jacob D Washburn, Teclemariam Weldekidan, Wenwei Xu, Natalia de Leon
OBJECTIVES: This release note describes the Maize GxE project datasets within the Genomes to Fields (G2F) Initiative. The Maize GxE project aims to understand genotype by environment (GxE) interactions and use the information collected to improve resource allocation efficiency and increase genotype predictability and stability, particularly in scenarios of variable environmental patterns. Hybrids and inbreds are evaluated across multiple environments and phenotypic, genotypic, environmental, and metadata information are made publicly available...
September 14, 2023: BMC Research Notes
#9
JOURNAL ARTICLE
Yannan Huang, Laura Sompii-Montgomery, Jessica Patti, Alex Pickering, Shima Yasin, Thuy Do, Elizabeth Baker, Denny Gao, Rabheh Abdul-Aziz, Edward M Behrens, Scott Canna, Matthew Clark, Dominic O Co, Kathleen P Collins, Barbara Eberhard, Monica Friedman, Thomas B Graham, Timothy Hahn, Aimee O Hersh, Patricia Hobday, Michael J Holland, Jennifer Huggins, Pai-Yue Lu, Melissa L Mannion, Cynthia K Manos, Jessica Neely, Karen Onel, Amir B Orandi, Andrea Ramirez, Adam Reinhardt, Mona Riskalla, Laisa Santiago, Matthew L Stoll, Tracy Ting, Alexei A Grom, Christopher Towe, Grant S Schulert
OBJECTIVE: Systemic juvenile idiopathic arthritis-associated lung disease (SJIA-LD) is a life-threatening disease complication. Key questions remain regarding clinical course and optimal treatment approaches. The objectives of the study were to detail management strategies after SJIA-LD detection, characterize overall disease courses, and measure long-term outcomes. METHODS: This was a prospective cohort study. Clinical data were abstracted from the electronic medical record, including current clinical status and changes since diagnosis...
September 10, 2023: Arthritis Care & Research
#10
JOURNAL ARTICLE
Zixiao Annie An, Kelli W Williams, Amanda Urban, Sania Ali, Susan Roy, Christine Lafeer, Jennifer Heimall, Victoria R Dimitriades, Joie Davis, Heidi H Kong, Edward W Cowen, Steven M Holland, Alexandra F Freeman
No abstract text is available yet for this article.
September 6, 2023: Journal of Allergy and Clinical Immunology in Practice
#11
JOURNAL ARTICLE
Edward L Hannan, Ye Zhong, Kimberly Cozzens, Frederick S K Ling, Alice K Jacobs, Spencer B King, Jacqueline Tamis-Holland, Ferdinand J Venditti, Peter B Berger
Risk models and risk scores derived from those models require periodic updating to account for changes in procedural performance, patient mix, and new risk factors added to existing systems. No risk model or risk score exists for predicting in-hospital/30-day mortality for percutaneous coronary interventions (PCIs) using contemporary data. This study develops an updated risk model and simplified risk score for in-hospital/30-day mortality following PCI. To accomplish this, New York's Percutaneous Coronary Intervention Reporting System was used to develop a logistic regression model and a simplified risk score model for predicting in-hospital/30-day mortality and to validate both models based on New York data from the previous year...
September 5, 2023: American Journal of Cardiology
#12
MULTICENTER STUDY
Alissa M D'Gama, Sarah Mulhern, Beth R Sheidley, Fadil Boodhoo, Sarah Buts, Natalie J Chandler, Joanna Cobb, Meredith Curtis, Edward J Higginbotham, Jonathon Holland, Tayyaba Khan, Julia Koh, Nicole S Y Liang, Lyndsey McRae, Sarah E Nesbitt, Brandon T Oby, Ben Paternoster, Alistair Patton, Graham Rose, Elizabeth Scotchman, Rozalia Valentine, Kimberly N Wiltrout, Robin Z Hayeems, Puneet Jain, Sebastian Lunke, Christian R Marshall, Shira Rockowitz, Neil J Sebire, Zornitza Stark, Susan M White, Lyn S Chitty, J Helen Cross, Ingrid E Scheffer, Vann Chau, Gregory Costain, Annapurna Poduri, Katherine B Howell, Amy McTague
BACKGROUND: Most neonatal and infantile-onset epilepsies have presumed genetic aetiologies, and early genetic diagnoses have the potential to inform clinical management and improve outcomes. We therefore aimed to determine the feasibility, diagnostic yield, and clinical utility of rapid genome sequencing in this population. METHODS: We conducted an international, multicentre, cohort study (Gene-STEPS), which is a pilot study of the International Precision Child Health Partnership (IPCHiP)...
September 2023: Lancet Neurology
#13
REVIEW
Edward J Holland, Albert Y Cheung, Ali R Djalilian, Marjan Farid, Mark J Mannis
PURPOSE: To highlight the paucity of surgeons performing ocular surface stem cell transplantation with systemic immunosuppression (OSSTx with SI) for limbal stem cell deficiency (LSCD) patients, suboptimal treatments for LSCD, and obstacles to adoption. METHODS: A review of the Eye Bank Association of America annual reports and the authors' case volume for OSSTx with SI was performed. Examination of the published literature on corneal surgeries, especially for LSCD, was completed...
September 1, 2023: Cornea
#14
JOURNAL ARTICLE
Edward L Hannan, Ye Zhong, Kimberly Cozzens, Alice K Jacobs, Spencer B King, Jacqueline Tamis-Holland, Frederick S K Ling, Gary Walford, Ferdinand J Venditti, Peter B Berger, Rodolfo Rocha
BACKGROUND: There is very little information about the use of ad hoc percutaneous coronary intervention (PCI) in stable patients with multivessel (MV) disease or unprotected left main (LM) disease patients for whom a heart team approach is recommended. OBJECTIVE: To identify the extent of ad hoc PCI utilization for patients with multivessel disease or left main disease, and to explore the inter-hospital variation in ad hoc PCI utilization for those patients. METHODS: New York State's cardiac registries were used to examine the use and variation in use of ad hoc PCI for MV/LM disease as a percentage of all MV/LM PCIs and revascularizations (PCIs plus coronary artery bypass graft procedures) during 2018 to 2019 in New York...
July 24, 2023: JACC. Cardiovascular Interventions
#15
Eric M Isselbacher, Ourania Preventza, James Hamilton Black, John G Augoustides, Adam W Beck, Michael A Bolen, Alan C Braverman, Bruce E Bray, Maya M Brown-Zimmerman, Edward P Chen, Tyrone J Collins, Abe DeAnda, Christina L Fanola, Leonard N Girardi, Caitlin W Hicks, Dawn S Hui, William Schuyler Jones, Vidyasagar Kalahasti, Karen M Kim, Dianna M Milewicz, Gustavo S Oderich, Laura Ogbechie, Susan B Promes, Elsie Gyang Ross, Marc L Schermerhorn, Sabrina Singleton Times, Elaine E Tseng, Grace J Wang, Y Joseph Woo, David P Faxon, Gilbert R Upchurch, Aaron W Aday, Ali Azizzadeh, Michael Boisen, Beau Hawkins, Christopher M Kramer, Jessica G Y Luc, Thomas E MacGillivray, S Christopher Malaisrie, Kathryn Osteen, Himanshu J Patel, Parag J Patel, Wanda M Popescu, Evelio Rodriguez, Rebecca Sorber, Philip S Tsao, Annabelle Santos Volgman, Joshua A Beckman, Catherine M Otto, Patrick T O'Gara, Anastasia Armbruster, Kim K Birtcher, Lisa de Las Fuentes, Anita Deswal, Dave L Dixon, Bulent Gorenek, Norrisa Haynes, Adrian F Hernandez, José A Joglar, W Schuyler Jones, Daniel Mark, Debabrata Mukherjee, Latha Palaniappan, Mariann R Piano, Tanveer Rab, Erica S Spatz, Jacqueline E Tamis-Holland, Y Joseph Woo
AIM: The "2022 ACC/AHA Guideline for the Diagnosis and Management of Aortic Disease" provides recommendations to guide clinicians in the diagnosis, genetic evaluation and family screening, medical therapy, endovascular and surgical treatment, and long-term surveillance of patients with aortic disease across its multiple clinical presentation subsets (ie, asymptomatic, stable symptomatic, and acute aortic syndromes). METHODS: A comprehensive literature search was conducted from January 2021 to April 2021, encompassing studies, reviews, and other evidence conducted on human subjects that were published in English from PubMed, EMBASE, the Cochrane Library, CINHL Complete, and other selected databases relevant to this guideline...
November 2023: Journal of Thoracic and Cardiovascular Surgery
#16
JOURNAL ARTICLE
Brigette Boast, Shubham Goel, Luis I González-Granado, Julie Niemela, Jennifer Stoddard, Emily S J Edwards, Sandali Seneviratne, Dominik Spensberger, Juan F Quesada, Luis M Allende, John McDonnell, Alexandria Haseley, Harry Lesmana, Magdalena A Walkiewicz, Emad Muhammad, Julian J Bosco, Thomas A Fleisher, Shai Cohen, Steven M Holland, Menno C van Zelm, Anselm Enders, Hye Sun Kuehn, Sergio D Rosenzweig
BACKGROUND: TCF3 is a transcription factor contributing to early lymphocyte differentiation. Germline monoallelic dominant negative (DN) and biallelic loss-of-function (LOF) Null TCF3 mutations cause a fully penetrant severe immunodeficiency. We identified 8 individuals from 7 unrelated families with monoallelic LOF TCF3 variants presenting with immunodeficiency with incomplete clinical penetrance. OBJECTIVE: To define TCF3 haploinsufficiency biology and its association with immunodeficiency...
June 3, 2023: Journal of Allergy and Clinical Immunology
#17
JOURNAL ARTICLE
Dayane Cristina Lima, Alejandro Castro Aviles, Ryan Timothy Alpers, Bridget A McFarland, Shawn Kaeppler, David Ertl, Maria Cinta Romay, Joseph L Gage, James Holland, Timothy Beissinger, Martin Bohn, Edward Buckler, Jode Edwards, Sherry Flint-Garcia, Candice N Hirsch, Elizabeth Hood, David C Hooker, Joseph E Knoll, Judith M Kolkman, Sanzhen Liu, John McKay, Richard Minyo, Danilo E Moreta, Seth C Murray, Rebecca Nelson, James C Schnable, Rajandeep S Sekhon, Maninder P Singh, Peter Thomison, Addie Thompson, Mitchell Tuinstra, Jason Wallace, Jacob D Washburn, Teclemariam Weldekidan, Randall J Wisser, Wenwei Xu, Natalia de Leon
OBJECTIVES: This report provides information about the public release of the 2018-2019 Maize G X E project of the Genomes to Fields (G2F) Initiative datasets. G2F is an umbrella initiative that evaluates maize hybrids and inbred lines across multiple environments and makes available phenotypic, genotypic, environmental, and metadata information. The initiative understands the necessity to characterize and deploy public sources of genetic diversity to face the challenges for more sustainable agriculture in the context of variable environmental conditions...
May 25, 2023: BMC genomic data
#18
JOURNAL ARTICLE
Alessia Alunno, Tadej Avcin, Catherine Haines, Sofia Ramiro, Francisca Sivera, Sara Badreh, Xenofon Baraliakos, Johannes W J Bijlsma, Frank Buttgereit, Kaushik Chaudhuri, Jose A P Da Silva, Jean Dudler, Ricardo J O Ferreira, Tania Gudu, Eric Hachulla, Mette Holland-Fischer, Annamaria Iagnocco, Tue Wenzel Kragstrup, György Nagy, Vasco C Romão, Simon R Stones, Marloes van Onna, Christopher J Edwards
BACKGROUND: Postgraduate rheumatology training programmes are already established at a national level in most European countries. However, previous work has highlighted a substantial level of heterogeneity in the organisation and, in part, content of programmes. OBJECTIVE: To define competences and standards of knowledge, skills and professional behaviours required for the training of rheumatologists. METHODS: A European Alliance of Associations for Rheumatology (EULAR) task force (TF) of 23 experts, including two members of the European Union of Medical Specialists (UEMS) section of rheumatology, was convened...
August 2023: Annals of the Rheumatic Diseases
#19
JOURNAL ARTICLE
Matthew J Simpson, Carly Ritger, Jason A Hoppe, Wesley C Holland, Megan A Morris, Bidisha Nath, Edward R Melnick, Caroline Tietbohl
BACKGROUND: Untreated opioid use disorder (OUD) is a significant public health problem. Buprenorphine is an evidence-based treatment for OUD that can be initiated in and prescribed from emergency departments (EDs) and office settings. Adoption of buprenorphine initiation among ED clinicians is low. The EMBED pragmatic clinical trial investigated the effectiveness of a clinical decision support (CDS) tool to promote ED clinicians' behavior related to buprenorphine initiation in the ED...
April 20, 2023: Implementation science communications
#20
RANDOMIZED CONTROLLED TRIAL
Thomas M Atkinson, Shelly Lensing, Jeannette Y Lee, Di Chang, Soo Young Kim, Yuelin Li, Kathleen A Lynch, Andrew Webb, Susan M Holland, Erica I Lubetkin, Stephen Goldstone, Mark H Einstein, Elizabeth A Stier, Dorothy J Wiley, Ronald Mitsuyasu, Isabella Rosa-Cunha, David M Aboulafia, Shireesha Dhanireddy, Jeffrey T Schouten, Rebecca Levine, Edward Gardner, Jeffrey Logan, Hillary Dunleavy, Luis F Barroso, Gary Bucher, Jessica Korman, Benjamin Stearn, Timothy J Wilkin, Grant Ellsworth, Julia C Pugliese, Abigail Arons, Jack E Burkhalter, David Cella, J Michael Berry-Lawhorn, Joel M Palefsky
PURPOSE: To determine whether treatment of anal high-grade squamous intraepithelial lesions (HSIL), vs active monitoring, is effective in reducing incidence of anal cancer in persons living with HIV, the US National Cancer Institute funded the Phase III ANal Cancer/HSIL Outcomes Research (ANCHOR) clinical trial. As no established patient-reported outcomes (PRO) tool exists for persons with anal HSIL, we sought to estimate the construct validity and responsiveness of the ANCHOR Health-Related Symptom Index (A-HRSI)...
August 2023: Quality of Life Research
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