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Daniel Edward Horner, Sarah Davis, Abdullah Pandor, Helen Shulver, Steve Goodacre, Daniel Hind, Saleema Rex, Michael Gillett, Matthew Bursnall, Xavier Griffin, Mark Holland, Beverley Jane Hunt, Kerstin de Wit, Shan Bennett, Robin Pierce-Williams
BACKGROUND: Pharmacological prophylaxis during hospital admission can reduce the risk of acquired blood clots (venous thromboembolism) but may cause complications, such as bleeding. Using a risk assessment model to predict the risk of blood clots could facilitate selection of patients for prophylaxis and optimise the balance of benefits, risks and costs. OBJECTIVES: We aimed to identify validated risk assessment models and estimate their prognostic accuracy, evaluate the cost-effectiveness of different strategies for selecting hospitalised patients for prophylaxis, assess the feasibility of using efficient research methods and estimate key parameters for future research...
April 2024: Health Technology Assessment: HTA
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JOURNAL ARTICLE
Doonyaporn Wongsawaeng, Daniel Schwartz, Xin Li, Leslie L Muldoon, Jared Stoller, Cooper Stateler, Samantha Holland, Laszlo Szidonya, William D Rooney, Cory Wyatt, Prakash Ambady, Rongwei Fu, Edward A Neuwelt, Ramon F Barajas
PURPOSE: To compare DSC-MRI using Gadolinium (GBCA) and Ferumoxytol (FBCA) in high-grade glioma at 3T and 7T MRI field strengths. We hypothesized that using FBCA at 7T would enhance the performance of DSC, as measured by contrast-to-noise ratio (CNR). METHODS: Ten patients (13 lesions) were assigned to 3T (6 patients, 6 lesions) or 7T (4 patients, 7 lesions). All lesions received 0.1 mmol/kg of GBCA on day 1. Ten lesions (4 at 3T and 6 at 7T) received a lower dose (0...
March 27, 2024: Neuroradiology Journal
#3
JOURNAL ARTICLE
Muhammad B Khalid, Ellen Zektser, Eric Chu, Min Li, Joanna Utoh, Patrick Ryan, Hanna S Loving, Roa Harb, Robbie Kattappuram, Lindsay Chatman, Stella Hartono, Estefania Claudio-Etienne, Guangping Sun, Edward P Feener, Zhongbo Li, Samuel K Lai, Quang Le, Lawrence B Schwartz, Jonathan J Lyons, Hirsh Komarow, Zhao-Hua Zhou, Haniya Raza, Maryland Pao, Karen Laky, Steven M Holland, Erica Brittain, Pamela A Frischmeyer-Guerrerio
BACKGROUND: Systemic allergic reactions (sARs) following coronavirus disease-2019 (COVID-19) mRNA vaccines were initially reported at a higher rate than traditional vaccines. OBJECTIVE: We aimed to evaluate the safety of revaccination in these individuals and to interrogate mechanisms underlying these reactions. METHODS: In this randomized, double-blinded, phase 2 trial, individuals 16-69 years who previously reported a convincing sAR to their first dose of COVID-19 mRNA vaccine were randomly assigned to receive second dose of BNT162b2 (Pfizer-BioNTech; Comirnaty®) vaccine and placebo on consecutive days in a blinded, 1:1 cross-over fashion at the National Institutes of Health (NIH)...
March 7, 2024: Journal of Allergy and Clinical Immunology
#4
JOURNAL ARTICLE
Moussa Mansour, Edward P Gerstenfeld, Chinmay Patel, Andrea Natale, William Whang, Frank A Cuoco, Stavros E Mountantonakis, Douglas N Gibson, John D Harding, Scott K Holland, Anitha B Achyutha, Christopher W Schneider, Andrew S Mugglin, Elizabeth M Albrecht, Kenneth M Stein, John W Lehmann, Vivek Y Reddy
BACKGROUND: When it occurs, pulmonary vein (PV) stenosis after atrial fibrillation (AF) ablation is associated with significant morbidity. Even mild-to-moderate PV narrowing may have long-term implications. Unlike thermal ablation energies such as radiofrequency (RF) or cryothermy, pulsed field ablation (PFA) is a non-thermal modality associated with less fibrotic proliferation. Herein, we compared the effects of PFA vs thermal ablation on PV narrowing after AF ablation. METHODS: ADVENT was a multicenter, randomized, single-blind study comparing PFA (pentaspline catheter) with thermal ablation - force-sensing RF or cryoballoon (CB) - to treat drug-refractory paroxysmal AF...
February 2, 2024: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
#5
RANDOMIZED CONTROLLED TRIAL
Edward Holland, Paul Karpecki, Murray Fingeret, Jack Schaeffer, Preeya Gupta, Nicole Fram, Gerard Smits, Teresa Ignacio, Richard Lindstrom
PURPOSE: This study was undertaken to evaluate the safety and efficacy of CSF-1 (0.4% pilocarpine hydrochloride ophthalmic solution) for use in individuals with presbyopia. METHODS: Two Phase 3 multicenter, randomized, double-masked, vehicle-controlled, parallel-group clinical trials were conducted in 35 private ophthalmology clinics in the United States from October 2020 to February 2022. Key inclusion criteria were the following: (1) age 45-64 years, (2) distance-corrected near visual acuity (DCNVA) at 40 cm ≥0...
February 2024: Clinical Therapeutics
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JOURNAL ARTICLE
R Donald Harvey, Therica M Miller, Patricia A Hurley, Ramya Thota, Lora J Black, Suanna S Bruinooge, Leigh M Boehmer, Mark E Fleury, Jasmine Kamboj, Mujahid A Rizvi, Banu E Symington, William D Tap, David M Waterhouse, Laura A Levit, Janette K Merrill, Sheila A Prindiville, Teri Pollastro, Jamie R Brewer, Leslie P Byatt, Leila Hamroun, Edward S Kim, Nicole Holland, Grzegorz S Nowakowski
No abstract text is available yet for this article.
January 9, 2024: Cancer
#7
JOURNAL ARTICLE
Pedram Hamrah, Mina Massaro-Giordano, David Schanzlin, Edward Holland, Gregg Berdy, Giovanni Goisis, Georgea Pasedis, Flavio Mantelli
INTRODUCTION: Cenegermin is approved for treatment of neurotrophic keratopathy (NK) and has been studied in patients with stage 2 or 3 NK. This study evaluated the efficacy and safety of cenegermin in adults with stage 1 NK. METHODS: This was a phase IV, multicenter, prospective, open-label, uncontrolled trial. Adults with stage 1 NK (Mackie criteria) and decreased corneal sensitivity (≤ 4 cm) received 1 drop of cenegermin 20 mcg/ml in the affected eye(s) 6 times/day for 8 weeks with a 24-week follow-up...
January 4, 2024: Ophthalmology and Therapy
#8
JOURNAL ARTICLE
Edward L Hannan, Yifeng Wu, Lamia Harik, Jacqueline Tamis-Holland, Alice K Jacobs, Joanna Chikwe, Kimberly S Cozzens, Mario Gaudino
OBJECTIVE: To compare outcomes in women undergoing percutaneous coronary intervention (PCI) and coronary artery bypass graft (CABG) surgery. DESIGN: This retrospective, propensity-score matched cohort study from the New York State cardiac registry (2012-2018) included all women with multivessel coronary artery disease undergoing PCI with everolimus-eluting stents (EES) and CABG surgery. The primary outcome was all-cause mortality. The key secondary outcome was major adverse cardiac events, defined as the composite of all-cause mortality, myocardial infarction, and stroke...
December 14, 2023: Journal of Thoracic and Cardiovascular Surgery
#9
JOURNAL ARTICLE
Rebecca R Chamley, Jennifer L Holland, Jonathan Collins, Kayleigh Pierce, William D Watson, Peregrine G Green, David O'Brien, Oliver O'Sullivan, Robert Barker-Davies, Peter Ladlow, Stefan Neubauer, Alexander Bennett, Edward D Nicol, David A Holdsworth, Oliver J Rider
BACKGROUND: Since the COVID-19 pandemic, post-COVID syndrome (persistent symptoms/complications lasting >12 weeks) continues to pose medical and economic challenges. In military personnel, where optimal fitness is crucial, prolonged limitations affecting their ability to perform duties has occupational and psychological implications, impacting deployability and retention. Research investigating post-COVID syndrome exercise capacity and cardiopulmonary effects in military personnel is limited...
November 17, 2023: International Journal of Cardiology
#10
JOURNAL ARTICLE
Alistair T Pagnamenta, Carme Camps, Edoardo Giacopuzzi, John M Taylor, Mona Hashim, Eduardo Calpena, Pamela J Kaisaki, Akiko Hashimoto, Jing Yu, Edward Sanders, Ron Schwessinger, Jim R Hughes, Gerton Lunter, Helene Dreau, Matteo Ferla, Lukas Lange, Yesim Kesim, Vassilis Ragoussis, Dimitrios V Vavoulis, Holger Allroggen, Olaf Ansorge, Christian Babbs, Siddharth Banka, Benito Baños-Piñero, David Beeson, Tal Ben-Ami, David L Bennett, Celeste Bento, Edward Blair, Charlotte Brasch-Andersen, Katherine R Bull, Holger Cario, Deirdre Cilliers, Valerio Conti, E Graham Davies, Fatima Dhalla, Beatriz Diez Dacal, Yin Dong, James E Dunford, Renzo Guerrini, Adrian L Harris, Jane Hartley, Georg Hollander, Kassim Javaid, Maureen Kane, Deirdre Kelly, Dominic Kelly, Samantha J L Knight, Alexandra Y Kreins, Erika M Kvikstad, Craig B Langman, Tracy Lester, Kate E Lines, Simon R Lord, Xin Lu, Sahar Mansour, Adnan Manzur, Reza Maroofian, Brian Marsden, Joanne Mason, Simon J McGowan, Davide Mei, Hana Mlcochova, Yoshiko Murakami, Andrea H Németh, Steven Okoli, Elizabeth Ormondroyd, Lilian Bomme Ousager, Jacqueline Palace, Smita Y Patel, Melissa M Pentony, Chris Pugh, Aboulfazl Rad, Archana Ramesh, Simone G Riva, Irene Roberts, Noémi Roy, Outi Salminen, Kyleen D Schilling, Caroline Scott, Arjune Sen, Conrad Smith, Mark Stevenson, Rajesh V Thakker, Stephen R F Twigg, Holm H Uhlig, Richard van Wijk, Barbara Vona, Steven Wall, Jing Wang, Hugh Watkins, Jaroslav Zak, Anna H Schuh, Usha Kini, Andrew O M Wilkie, Niko Popitsch, Jenny C Taylor
BACKGROUND: Whole genome sequencing is increasingly being used for the diagnosis of patients with rare diseases. However, the diagnostic yields of many studies, particularly those conducted in a healthcare setting, are often disappointingly low, at 25-30%. This is in part because although entire genomes are sequenced, analysis is often confined to in silico gene panels or coding regions of the genome. METHODS: We undertook WGS on a cohort of 122 unrelated rare disease patients and their relatives (300 genomes) who had been pre-screened by gene panels or arrays...
November 9, 2023: Genome Medicine
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JOURNAL ARTICLE
#12
JOURNAL ARTICLE
Merritt Khaipho-Burch, Mark Cooper, Jose Crossa, Natalia de Leon, James Holland, Ramsey Lewis, Susan McCouch, Seth C Murray, Ismail Rabbi, Pamela Ronald, Jeffrey Ross-Ibarra, Detlef Weigel, Edward S Buckler
No abstract text is available yet for this article.
September 2023: Nature
#13
JOURNAL ARTICLE
Dayane Cristina Lima, Alejandro Castro Aviles, Ryan Timothy Alpers, Alden Perkins, Dylan L Schoemaker, Martin Costa, Kathryn J Michel, Shawn Kaeppler, David Ertl, Maria Cinta Romay, Joseph L Gage, James Holland, Timothy Beissinger, Martin Bohn, Edward Buckler, Jode Edwards, Sherry Flint-Garcia, Michael A Gore, Candice N Hirsch, Joseph E Knoll, John McKay, Richard Minyo, Seth C Murray, James Schnable, Rajandeep S Sekhon, Maninder P Singh, Erin E Sparks, Peter Thomison, Addie Thompson, Mitchell Tuinstra, Jason Wallace, Jacob D Washburn, Teclemariam Weldekidan, Wenwei Xu, Natalia de Leon
OBJECTIVES: This release note describes the Maize GxE project datasets within the Genomes to Fields (G2F) Initiative. The Maize GxE project aims to understand genotype by environment (GxE) interactions and use the information collected to improve resource allocation efficiency and increase genotype predictability and stability, particularly in scenarios of variable environmental patterns. Hybrids and inbreds are evaluated across multiple environments and phenotypic, genotypic, environmental, and metadata information are made publicly available...
September 14, 2023: BMC Research Notes
#14
JOURNAL ARTICLE
Yannan Huang, Laura Sompii-Montgomery, Jessica Patti, Alex Pickering, Shima Yasin, Thuy Do, Elizabeth Baker, Denny Gao, Rabheh Abdul-Aziz, Edward M Behrens, Scott Canna, Matthew Clark, Dominic O Co, Kathleen P Collins, Barbara Eberhard, Monica Friedman, Thomas B Graham, Timothy Hahn, Aimee O Hersh, Patricia Hobday, Michael J Holland, Jennifer Huggins, Pai-Yue Lu, Melissa L Mannion, Cynthia K Manos, Jessica Neely, Karen Onel, Amir B Orandi, Andrea Ramirez, Adam Reinhardt, Mona Riskalla, Laisa Santiago, Matthew L Stoll, Tracy Ting, Alexei A Grom, Christopher Towe, Grant S Schulert
OBJECTIVE: Systemic juvenile idiopathic arthritis-associated lung disease (SJIA-LD) is a life-threatening disease complication. Key questions remain regarding clinical course and optimal treatment approaches. The objectives of the study were to detail management strategies after SJIA-LD detection, characterize overall disease courses, and measure long-term outcomes. METHODS: This was a prospective cohort study. Clinical data were abstracted from the electronic medical record, including current clinical status and changes since diagnosis...
September 10, 2023: Arthritis Care & Research
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JOURNAL ARTICLE
Zixiao Annie An, Kelli W Williams, Amanda Urban, Sania Ali, Susan Roy, Christine Lafeer, Jennifer Heimall, Victoria R Dimitriades, Joie Davis, Heidi H Kong, Edward W Cowen, Steven M Holland, Alexandra F Freeman
No abstract text is available yet for this article.
September 6, 2023: Journal of Allergy and Clinical Immunology in Practice
#16
JOURNAL ARTICLE
Edward L Hannan, Ye Zhong, Kimberly Cozzens, Frederick S K Ling, Alice K Jacobs, Spencer B King, Jacqueline Tamis-Holland, Ferdinand J Venditti, Peter B Berger
Risk models and risk scores derived from those models require periodic updating to account for changes in procedural performance, patient mix, and new risk factors added to existing systems. No risk model or risk score exists for predicting in-hospital/30-day mortality for percutaneous coronary interventions (PCIs) using contemporary data. This study develops an updated risk model and simplified risk score for in-hospital/30-day mortality following PCI. To accomplish this, New York's Percutaneous Coronary Intervention Reporting System was used to develop a logistic regression model and a simplified risk score model for predicting in-hospital/30-day mortality and to validate both models based on New York data from the previous year...
September 5, 2023: American Journal of Cardiology
#17
MULTICENTER STUDY
Alissa M D'Gama, Sarah Mulhern, Beth R Sheidley, Fadil Boodhoo, Sarah Buts, Natalie J Chandler, Joanna Cobb, Meredith Curtis, Edward J Higginbotham, Jonathon Holland, Tayyaba Khan, Julia Koh, Nicole S Y Liang, Lyndsey McRae, Sarah E Nesbitt, Brandon T Oby, Ben Paternoster, Alistair Patton, Graham Rose, Elizabeth Scotchman, Rozalia Valentine, Kimberly N Wiltrout, Robin Z Hayeems, Puneet Jain, Sebastian Lunke, Christian R Marshall, Shira Rockowitz, Neil J Sebire, Zornitza Stark, Susan M White, Lyn S Chitty, J Helen Cross, Ingrid E Scheffer, Vann Chau, Gregory Costain, Annapurna Poduri, Katherine B Howell, Amy McTague
BACKGROUND: Most neonatal and infantile-onset epilepsies have presumed genetic aetiologies, and early genetic diagnoses have the potential to inform clinical management and improve outcomes. We therefore aimed to determine the feasibility, diagnostic yield, and clinical utility of rapid genome sequencing in this population. METHODS: We conducted an international, multicentre, cohort study (Gene-STEPS), which is a pilot study of the International Precision Child Health Partnership (IPCHiP)...
September 2023: Lancet Neurology
#18
REVIEW
Edward J Holland, Albert Y Cheung, Ali R Djalilian, Marjan Farid, Mark J Mannis
PURPOSE: To highlight the paucity of surgeons performing ocular surface stem cell transplantation with systemic immunosuppression (OSSTx with SI) for limbal stem cell deficiency (LSCD) patients, suboptimal treatments for LSCD, and obstacles to adoption. METHODS: A review of the Eye Bank Association of America annual reports and the authors' case volume for OSSTx with SI was performed. Examination of the published literature on corneal surgeries, especially for LSCD, was completed...
September 1, 2023: Cornea
#19
JOURNAL ARTICLE
Edward L Hannan, Ye Zhong, Kimberly Cozzens, Alice K Jacobs, Spencer B King, Jacqueline Tamis-Holland, Frederick S K Ling, Gary Walford, Ferdinand J Venditti, Peter B Berger, Rodolfo Rocha
BACKGROUND: There is very little information about the use of ad hoc percutaneous coronary intervention (PCI) in stable patients with multivessel (MV) disease or unprotected left main (LM) disease patients for whom a heart team approach is recommended. OBJECTIVE: To identify the extent of ad hoc PCI utilization for patients with multivessel disease or left main disease, and to explore the inter-hospital variation in ad hoc PCI utilization for those patients. METHODS: New York State's cardiac registries were used to examine the use and variation in use of ad hoc PCI for MV/LM disease as a percentage of all MV/LM PCIs and revascularizations (PCIs plus coronary artery bypass graft procedures) during 2018 to 2019 in New York...
July 24, 2023: JACC. Cardiovascular Interventions
#20
JOURNAL ARTICLE
Dayane Cristina Lima, Jacob D Washburn, José Ignacio Varela, Qiuyue Chen, Joseph L Gage, Maria Cinta Romay, James Holland, David Ertl, Marco Lopez-Cruz, Fernando M Aguate, Gustavo de Los Campos, Shawn Kaeppler, Timothy Beissinger, Martin Bohn, Edward Buckler, Jode Edwards, Sherry Flint-Garcia, Michael A Gore, Candice N Hirsch, Joseph E Knoll, John McKay, Richard Minyo, Seth C Murray, Osler A Ortez, James C Schnable, Rajandeep S Sekhon, Maninder P Singh, Erin E Sparks, Addie Thompson, Mitchell Tuinstra, Jason Wallace, Teclemariam Weldekidan, Wenwei Xu, Natalia de Leon
OBJECTIVES: The Genomes to Fields (G2F) 2022 Maize Genotype by Environment (GxE) Prediction Competition aimed to develop models for predicting grain yield for the 2022 Maize GxE project field trials, leveraging the datasets previously generated by this project and other publicly available data. DATA DESCRIPTION: This resource used data from the Maize GxE project within the G2F Initiative [1]. The dataset included phenotypic and genotypic data of the hybrids evaluated in 45 locations from 2014 to 2022...
July 17, 2023: BMC Research Notes
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