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thyroid eye dry

S L Hsu, P Y Lee, C H Chang, C H Chen
Thyroid orbitopathy (TO) is an autoimmune disease that is complicated by ocular surface disorders, leading to discomfort. Dry eye is very prevalent in patients with TO. Recent studies on the pathogenesis of dry eye have focused on the inflammatory process, and some supporting evidence has been discovered. Because TO is a disorder of autoimmune origin, we assumed that the association between TO and dry eye is related to inflammation. Inflammation of the ocular surface in TO-related dry eye has not been well studied...
August 30, 2016: Genetics and Molecular Research: GMR
Elisabeth M Messmer, Victoria von Lindenfels, Alexandra Garbe, Anselm Kampik
PURPOSE: To measure matrix metalloproteinase 9 (MMP-9) in the tear film of patients with dry eye disease (DED) compared with controls and to correlate clinical findings. DESIGN: In a prospective study, 101 patients and controls underwent MMP-9 testing of the tear film. Thereafter, they were evaluated for symptoms and signs of DED. PARTICIPANTS: Included patients were those who showed 3 of the following 4 dry eye criteria: ocular surface disease index (OSDI) score of more than 12, tear film break-up time (TBUT) of 10 seconds or less, Schirmer test results without anesthesia of less than 10 mm/5 minutes, and corneal staining results of 1 or more...
September 21, 2016: Ophthalmology
Fabricio Lopes da Fonseca, Patricia Kazue Yamanaka, Juliana Mika Kato, Suzana Matayoshi
BACKGROUND: Radioiodine therapy (RIT) is an established treatment for differentiated thyroid carcinomas and is widely used throughout the world, given the increasing incidence of this malignancy. Although serious adverse effects are infrequent, complications such as dry mouth, sialadenitis and dysphagia have been described. The involvement of the eyes and adnexa is not commonly discussed, despite dry eye, keratoconjunctivitis and lacrimal system obstruction (LSO) being reported, especially after high cumulative doses of radiopharmaceuticals...
August 26, 2016: Thyroid: Official Journal of the American Thyroid Association
Nur Aqilah Salleh, Wong Hon Seng, Hazlita Dato' Mohd Isa
In patients with thyroid disease, ocular involvement or thyroid ophthalmopathy is common, irrespective of their thyroid status. A common feature of thyroid eye disease is eyelid retraction, which leads to a classical starry gaze (Kocher sign). Treatment with radioactive iodine (RAI) is a known therapy for hyperthyroidism. However, this treatment may lead to or worsen thyroid ophthalmopathy. We report a case series of two patients with thyrotoxicosis, who presented with an atypical and subtle occurrence of thyroid eye disease (TED) soon after RAI therapy...
May 2016: Korean Journal of Family Medicine
So-Hyang Chung, Jun-Pyo Myong
OBJECTIVES: The purpose of this study was to investigate whether blood mercury concentrations associated with the presence of dry eye symptoms in a nationally representative Korean population. METHODS: Population-based prospective cross-sectional study using the heavy metal data set of the 2010-2012 Korean National Health and Nutrition Examination Survey (KNHANES). A total of 4761 adult Koreans were the eligible population in this study. Of the 7162 survey participants, 2401 were excluded because they were <19 years of age, there were missing data in the heavy metal data set, or they had diabetes, rheumatoid arthritis, thyroid disease, asthma, depression and/or under-the-eye surgery...
2016: BMJ Open
Sam Young Yoon, Seok Hyun Bae, Young Joo Shin, Shin Goo Park, Sang-Hee Hwang, Joon Young Hyon, Won Ryang Wee
BACKGROUND: Dry eye syndrome (DES) is a common tear film and ocular surface disease that results in discomfort, visual disturbance, and tear film instability with potential damage to the ocular surface. Systemic diseases associated with DES include diabetes mellitus, rheumatoid arthritis, depression, anxiety, thyroid disease, allergic diseases, irritable bowel syndrome, chronic pain syndrome, and hyperlipidemia. Interestingly, it has been found that most of these are associated with low levels of serum 25-hydroxyvitamin D (25(OH)D) or inadequate sunlight exposure...
2016: PloS One
Hyun Cheol Roh, Jimmy K Lee, Martha Kim, Jong-Hyun Oh, Min-Wook Chang, Roy S Chuck, Choul Yong Park
PURPOSE: To identify systemic comorbidities in patients with dry eye syndrome in South Korea. METHODS: From 2010 to 2012, 17,364 participants aged 20 or older were randomly included in the nationwide Korean National Health and Nutrition Examination Survey V. The prevalence of dry eye syndrome and demographics of these patients were investigated. We performed conditional logistic regression analyses based on age, sex, residential area, education level, occupation type, and household income level to obtain the odds ratio for each systemic comorbidity among subjects with and without dry eye syndrome...
February 2016: Cornea
Nina Matheis, Franz H Grus, Matthias Breitenfeld, Ivo Knych, Sebastian Funke, Susanne Pitz, Katharina A Ponto, Norbert Pfeiffer, George J Kahaly
PURPOSE: In patients with thyroid-associated orbitopathy (TAO), the dry eye syndrome occurs frequently, and symptoms and signs of both disorders overlap making early and accurate differential diagnosis difficult. A differentiation via specific markers is warranted. METHODS: Tear fluid samples of 120 subjects with TAO, TAO + dry eye, dry eye, and controls were collected. The samples were measured using matrix-assisted laser desorption ionization mass spectrometry...
April 2015: Investigative Ophthalmology & Visual Science
Jessica H Selter, Anisa I Gire, Shameema Sikder
BACKGROUND: A complex relationship between Graves' ophthalmopathy (GO) and dry eye syndrome exists. New research brings more insight into the association between these two diseases. METHODS: A review of the literature was conducted using the query terms "Graves' Ophthalmopathy", "Thyroid Eye Disease", and "Dry Eye" in MedLine (PubMed) and Scopus. A total of 55 papers were reviewed. Case reports were excluded. CONCLUSION: This review paper shows the close relationship between dry eye syndrome and GO...
2015: Clinical Ophthalmology
Emrah Kan, Elif Kılıçkan, Gulçin Ecemiş, Emrullah Beyazyildiz, Ramis Çolak
Purpose. To evaluate the tear function tests in patients with Hashimoto's thyroiditis and to compare the results with healthy subjects. Methods. A hundred and ten patients with Hashimoto's thyroiditis and 100 healthy subjects were included in this study. The presence of thyroid-associated ophthalmopathy and tear function tests were evaluated clinically. The results were first compared between the patients and the control groups and then compared between patients with NOSPECS and patients without NOSPECS. Logistic regression analyses of the risk factors for dry eye including sex, gender, free plasma thyroxine, proptosis, upper eyelid margin-reflex distance, and duration of the disease were also evaluated...
2014: Journal of Ophthalmology
Hui Shan Sim, Andrea Petznick, Sylvaine Barbier, Jen Hong Tan, U Rajendra Acharya, Sharon Yeo, Louis Tong
AIM: The main treatment for meibomian gland dysfunction (MGD), a major cause of dry eye, is eyelid warming. Lack of compliance is the main reason for treatment failure. This has led to the development of eyelid-warming devices that are safe, effective and convenient. To obtain robust evidence demonstrating their efficacy, the authors conducted a 3-arm randomized clinical study. METHODS: The authors conducted a 3-month assessor-blinded, randomized, controlled trial of patients from the Singapore National Eye Centre experiencing at least one of eight dry eye symptoms 'often' or 'all the time'...
December 2014: Ophthalmology and Therapy
Ji Min Ahn, Seung Hyun Lee, Tyler Hyung Taek Rim, Ryoung Jin Park, Hong Seok Yang, Tae Im Kim, Kyung Chul Yoon, Kyoung Yul Seo
PURPOSE: To investigate the prevalence of and risk factors associated with dry eye syndrome (DES) in South Korea. DESIGN: Cross-sectional study. METHODS: In 2010 and 2011, 11,666 subjects, ranging in age from 19 to 95, were randomly selected as nationally representative participants in the Korea National Health and Nutrition Examination Survey (KNHANES). Subjects were divided into 2 groups: 1 with clinically diagnosed DES and 1 with symptoms of dry eye...
December 2014: American Journal of Ophthalmology
Claudia F Henrich, Pradeep Y Ramulu, Esen K Akpek
PURPOSE: The aim of this study was to review the frequency and types of inflammatory systemic diseases in a cohort of patients with dry eye, and identify clinical features suggesting the presence of these. METHODS: Consecutive new patients with a primary diagnosis of dry eye evaluated at a tertiary dry eye center between January 2010 and December 2011 were reviewed retrospectively. Standardized questionnaires were used to obtain data regarding systemic symptoms, previous medical diagnoses, and family history...
August 2014: Cornea
Armaghan Fard-Esfahani, Alireza Emami-Ardekani, Babak Fallahi, Pezhman Fard-Esfahani, Davood Beiki, Arman Hassanzadeh-Rad, Mohammad Eftekhari
Use of radioactive iodine is an essential adjuvant treatment strategy after thyroidectomy in patients with differentiated thyroid carcinoma. Although generally safe, radioiodine therapy has some potential side effects, classified as early and late complications, which we have reviewed in this paper. Early complications include gastrointestinal symptoms, radiation thyroiditis, sialadenitis/xerostomia, bone marrow suppression, gonadal damage, dry eye, and nasolacrimal duct obstruction. The late complications include secondary cancers, pulmonary fibrosis, permanent bone marrow suppression, and genetic effects...
August 2014: Nuclear Medicine Communications
Jennifer F Williamson, Kyle Huynh, Mark A Weaver, Richard M Davis
OBJECTIVE: To assess the perceptions of eye care providers regarding the clinical management of dry eye. METHODS: Invitations to complete a 17-question online survey were mailed to 400 members of the North Carolina Ophthalmology and Optometry Associations including community optometrists, comprehensive ophthalmologists, and cornea specialists. RESULTS: The survey was completed by 100 eye care providers (25% response rate). Providers reported burning (46...
March 2014: Eye & Contact Lens
A Bruscolini, A Abbouda, N Locuratolo, L Restivo, P Trimboli, F Romanelli
BACKGROUND: The present study aims to assess qualitative and quantitative characteristics of tear film and corneal related impairment and to evaluate the quality of life in a cohort of non-exophthalmic Graves' disease (GD) patients. METHODS: The series comprised 50 eyes from 25 newly diagnosed GD patients with no proptosis. As control group, 56 eyes of 28 thyroid disease-free subjects were enrolled. RESULTS: The results of Schirmer I and II, break-up time, and Oxford scheme showed a significant difference between GD and controls...
2015: Seminars in Ophthalmology
Adam J Paulsen, Karen J Cruickshanks, Mary E Fischer, Guan-Hua Huang, Barbara E K Klein, Ronald Klein, Dayna S Dalton
PURPOSE: To estimate dry eye prevalence in the Beaver Dam Offspring Study (BOSS), including a young adult population, and investigate associated risk factors and impact on health-related quality of life. DESIGN: Cohort study. METHODS: The BOSS (2005-2008) is a study of aging in the adult offspring of the population-based Epidemiology of Hearing Loss Study cohort. Questionnaire data on health history, medication use, risk factors, and quality of life were available for 3275 participants...
April 2014: American Journal of Ophthalmology
Marta Sacchetti, Flavio Mantelli, Alessandro Lambiase, Alessandra Mastropasqua, Daniela Merlo, Stefano Bonini
AIMS: Topical ciclosporin A (CsA) is a therapeutic option for dry eye disease (DED) to control ocular surface inflammation and improve tear function. The aim of this study is to systematically review data from randomised clinical trials (RCTs) evaluating efficacy and safety of topical CsA treatment for DED. METHODS: Articles published up to December 2012 were identified from Medline, Embase and the Cochrane Controlled Trials Register. A total of 18 RCTs that evaluated the efficacy and safety of different topical CsA formulations for the treatment of DED were selected according to the set criteria...
August 2014: British Journal of Ophthalmology
Beau J Fenner, Louis Tong
PURPOSE: To determine the reliability of single- and double-zone corneal fluorescent staining compared with five-zone analysis for the prediction of dry eye disease. METHODS: Prospective study of 510 subjects with dry eye disease characterized using corneal fluorescein staining, Schirmer scores, and tear break-up times. Corneal staining was quantified using Baylor scoring with ROC analysis used to assess predictive power of single- and double-zone compared with five-zone analysis for aqueous, evaporative, and mixed dry eye disease...
2013: Investigative Ophthalmology & Visual Science
J F Leatherland, S B Barrett
Total organism content of L-thyroxine (T4) and triiodo-L-thyronine (T3) were measured in the early developmental stages of a stock of Lake Ontario coho salmon from the egg to the yolk absorption stage. Whole organism T4 levels were constant between the egg and pre-hatch embryo stages, but fell progressively during yolk absorption. T3 levels were low from egg to eye-pigment appearance, but then increased prior to hatch and fell again during the post-hatch yolk absorption period.When expressed as ng/tissue, T4 content of the body compartment rose progressively between days 67 and 87 post-fertilization, whilst T4 content of the yolk compartment fell progressively during the same period; the pattern was not evident for tissue T3 content...
August 1993: Fish Physiology and Biochemistry
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