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https://www.readbyqxmd.com/read/27936188/risk-factors-for-complications-after-reduction-mammoplasty-a-meta-analysis
#1
Min-Xia Zhang, Chun-Ye Chen, Qing-Qing Fang, Ji-Hua Xu, Xiao-Feng Wang, Bang-Hui Shi, Li-Hong Wu, Wei-Qiang Tan
BACKGROUND: Reduction mammoplasty (RM) is a proven method of treating macromastia, but the risk factors for postoperative complications have not been clearly identified. Through this meta-analysis, the authors aimed to identify the risk factors of RM complications. METHODS: An extensive search of the literature describing complications after RM was performed using the PubMed Central, Embase, and Cochrane databases. The following risk factors were extracted: age, body mass index (BMI), tissue resection weight per breast (TRW), smoking and radiation therapy...
2016: PloS One
https://www.readbyqxmd.com/read/27936125/automatic-coronary-artery-calcium-scoring-on-radiotherapy-planning-ct-scans-of-breast-cancer-patients-reproducibility-and-association-with-traditional-cardiovascular-risk-factors
#2
Sofie A M Gernaat, Ivana Išgum, Bob D de Vos, Richard A P Takx, Danny A Young-Afat, Noor Rijnberg, Diederick E Grobbee, Yolanda van der Graaf, Pim A de Jong, Tim Leiner, Desiree H J van den Bongard, Jean-Philippe Pignol, Helena M Verkooijen
OBJECTIVES: Coronary artery calcium (CAC) is a strong and independent predictor of cardiovascular disease (CVD) risk. This study assesses reproducibility of automatic CAC scoring on radiotherapy planning computed tomography (CT) scans of breast cancer patients, and examines its association with traditional cardiovascular risk factors. METHODS: This study included 561 breast cancer patients undergoing radiotherapy between 2013 and 2015. CAC was automatically scored with an algorithm using supervised pattern recognition, expressed as Agatston scores and categorized into five categories (0, 1-10, 11-100, 101-400, >400)...
2016: PloS One
https://www.readbyqxmd.com/read/27936104/mechanical-loading-attenuates-radiation-induced-bone-loss-in-bone-marrow-transplanted-mice
#3
Peter M Govey, Yue Zhang, Henry J Donahue
Exposure of bone to ionizing radiation, as occurs during radiotherapy for some localized malignancies and blood or bone marrow cancers, as well as during space travel, incites dose-dependent bone morbidity and increased fracture risk. Rapid trabecular and endosteal bone loss reflects acutely increased osteoclastic resorption as well as decreased bone formation due to depletion of osteoprogenitors. Because of this dysregulation of bone turnover, bone's capacity to respond to a mechanical loading stimulus in the aftermath of irradiation is unknown...
2016: PloS One
https://www.readbyqxmd.com/read/27935967/large-scale-analysis-of-gene-expression-data-reveals-a-novel-gene-expression-signature-associated-with-colorectal-cancer-distant-recurrence
#4
Nehad M Alajez
Colorectal cancer (CRC) is the fourth-ranked cause of cancer-related deaths worldwide. Despite recent advances in CRC management, distant recurrence (DR) remains the major cause of mortality in patients with preoperative chemotherapy and radiotherapy, underscoring a need to precisely identify novel gene signatures for predicting the risk of systemic relapse. Herein, we integrated two independent CRC gene expression datasets: the GSE71222 dataset, including 26 patients who developed DR and 126 patients who did not develop DR, and the GSE21510 dataset, including 23 patients who developed DR and 76 patients who did not develop DR...
2016: PloS One
https://www.readbyqxmd.com/read/27935952/neoadjuvant-gemcitabine-chemotherapy-followed-by-concurrent-imrt-simultaneous-boost-achieves-high-r0-resection-in-borderline-resectable-pancreatic-cancer-patients
#5
Xiaolun Huang, Jeanna L Knoble, Ming Zeng, Fernando N Aguila, Tara Patel, Lowell W Chambers, Honglin Hu, Hao Liu
BACKGROUND: To study the feasibility of down stage the borderline resectable pancreatic cancer (BRPC) to resectable disease, we reported our institutional results using an intensity-modulated radiation therapy (IMRT) simultaneous integrated boost (SIB) dose escalation approach to improve R0 resectability. METHODS: We reviewed our past 7 years of experience of using neoadjuvant induction chemotherapy with Gemcitabine followed by concurrent chemoradiaiton for BRPC...
2016: PloS One
https://www.readbyqxmd.com/read/27935362/dramatic-radiographic-response-resulting-in-cerebrospinal-fluid-rhinorrhea-associated-with-sunitinib-therapy-in-recurrent-atypical-meningioma-case-report
#6
Amol Raheja, Howard Colman, Cheryl A Palmer, William T Couldwell
Sunitinib is a multiple tyrosine kinase inhibitor with antiangiogenic, cytostatic, and antimigratory activity for meningiomas. A recent clinical trial of sunitinib for treatment of recurrent Grade II and III meningiomas suggested potential efficacy in this population, but only 2 patients exhibited significant radiographic response with tumor volume reduction. The authors illustrate another such case and discuss a complication related to this dramatic tumor volume reduction in aggressive skull base meningiomas...
December 9, 2016: Journal of Neurosurgery
https://www.readbyqxmd.com/read/27935337/induction-of-interleukin-1%C3%AE-by-mouse-mammary-tumor-irradiation-promotes-triple-negative-breast-cancer-cells-invasion-and-metastasis-development
#7
Gina Bouchard, Hélène Therriault, Rachel Bujold, Caroline Saucier, Benoit Paquette
PURPOSE: Radiotherapy increases the level of inflammatory cytokines, some of which are known to promote metastasis. In a mouse model of triple negative breast cancer (TNBC), we determined whether irradiation of the mammary tumor increases the level of key cytokines and favors the development of lung metastases. MATERIAL AND METHODS: D2A1 TNBC cells were implanted in the mammary glands of a Balb/c mouse and then 7 days old tumors were irradiated (4x6 Gy). The cytokines IL-1β, IL-4, IL-6, IL-10, IL-17 and MIP-2 were quantified in plasma before, midway and after irradiation...
December 9, 2016: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/27935336/rrx-001-a-systemically-non-toxic-m2-to-m1-macrophage-stimulating-and-prosensitizing-agent-in-phase-ii-clinical-trials
#8
Bryan Oronsky, Ramasamy Paulmurugan, Kira Foygel, Jan Scicinski, Susan J Knox, Donna Peehl, Hongjuan Zhao, Shoucheng Ning, Pedro Cabrales, Thomas A Summers, Tony R Reid, William L Fitch, Michelle M Kim, Jane B Trepel, Min-Jung Lee, Santosh Kesari, Nacer D Abrouk, Regina M Day, Arnold Oronsky, Carolyn M Ray, Corey A Carter
According to Hanahan and Weinberg, cancer manifests as six essential physiologic hallmarks: 1) self-sufficiency in growth signals, 2) insensitivity to growth-inhibitory signals, 3) evasion of programmed cell death, 4) limitless replicative potential, 5) sustained angiogenesis, and 6) invasion and metastasis. As a facilitator of these traits as well as immunosuppression and chemoresistance, the presence of tumor-associated macrophages (TAMs) may serve as the seventh hallmark of cancer. Anticancer agents that successfully reprogram TAMs to target rather than support tumor cells may hold the key to better therapeutic outcomes...
December 9, 2016: Expert Opinion on Investigational Drugs
https://www.readbyqxmd.com/read/27935117/long-noncoding-rna-malat1-affects-the-efficacy-of-radiotherapy-for-esophageal-squamous-cell-carcinoma-by-regulating-cks1-expression
#9
Zhijun Li, Yang Zhou, Bo Tu, Yu Bu, Aqiu Liu, Conghua Xie
OBJECTIVE: Long noncoding RNA MALAT1 has been well-studied in the progression of many malignancies. However, its association with the radioresistance of tumors has not been well-understood yet. This study tried to explore the role of MALAT1 in regulating the radiosensitivity of esophageal cancer (EC), especially esophageal squamous cell carcinoma (ESCC), involving its regulation on Cks1 expression. METHODS: KYSE150 cells were subcutaneously inoculated into nude mice to establish ESCC xenografts...
December 9, 2016: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/27934896/transient-appearance-of-circulating-tumor-dna-associated-with-de-novo-treatment
#10
Kikuya Kato, Junji Uchida, Yoji Kukita, Toru Kumagai, Kazumi Nishino, Takako Inoue, Madoka Kimura, Fumio Imamura
The limitation of circulating tumor DNA (ctDNA) is its inability to detect cancer cell subpopulations with few or no dying cells. Lung cancer patients subjected to the EGFR tyrosine kinase inhibitor (EGFR-TKI) treatment were prospectively collected, and ctDNA levels represented by the activating and T790M mutations were measured. The first data set (21 patients) consisting of samples collected in the period from before initiation of EGFR-TKI to at least 2 weeks after initiation: the ctDNA dynamics generally exhibited a rapid decrease and/or a transient increase...
December 9, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27934883/preclinical-evaluation-of-radiation-and-systemic-rgd-targeted-adeno-associated-virus-phage-tnf-gene-therapy-in-a-mouse-model-of-spontaneously-metastatic-melanoma
#11
T J Quinn, N Healy, A Sara, E Maggi, C S Claros, R Kabarriti, L Scandiuzzi, L Liu, J Gorecka, A Adem, I Basu, Z Yuan, C Guha
The incidence of melanoma in the United States continues to rise, with metastatic lesions notoriously recalcitrant to therapy. There are limited effective treatment options available and a great need for more effective therapies that can be rapidly integrated in the clinic. In this study, we demonstrate that the combination of RGD-targeted adeno-associated virus phage (RGD-AAVP-TNF) with hypofractionated radiation therapy results in synergistic inhibition of primary syngeneic B16 melanoma in a C57 mouse model...
December 9, 2016: Cancer Gene Therapy
https://www.readbyqxmd.com/read/27934882/stable-knockdown-of-creb-hif-1-and-hif-2-by-replication-competent-retroviruses-abrogates-the-responses-to-hypoxia-in-hepatocellular-carcinoma
#12
D Shneor, R Folberg, J Pe'er, A Honigman, S Frenkel
The fast proliferation of tumor cells develops faster than the vasculature, resulting, in most malignant tumors, in generation of hypoxic regions. Hypoxia renders solid tumors resistant to radiation and chemotherapeutics while providing opportunities for tumor-selective therapies targeting tumor hypoxia. Here we exploit two properties of tumors: propagation of tumor cells and ongoing generation of hypoxic regions to construct a system that preferentially leads to the death of tumor cells and thus hinders tumor growth...
December 9, 2016: Cancer Gene Therapy
https://www.readbyqxmd.com/read/27934621/drug-resistant-epilepsy-after-treatment-for-childhood-acute-lymphocytic-leukaemia-from-focal-epilepsy-to-lennox-gastaut-syndrome
#13
Karina A González-Otárula, Blanca Mercedes Álvarez, François Dubeau
Drug-resistant epilepsy, not associated with acute brain complications or central nervous system leukaemic involvement, can develop in patients treated for acute lymphocytic leukaemia during childhood. It has been postulated that this rare complication may be due to CNS oncological treatment neurotoxicity, related to intrathecal drugs, such as methotrexate, and brain radiotherapy. We report four patients who developed drug-resistant epilepsy sometime after receiving treatment for acute lymphocytic leukaemia...
December 8, 2016: Epileptic Disorders: International Epilepsy Journal with Videotape
https://www.readbyqxmd.com/read/27933450/effects-of-exercise-intervention-in-breast-cancer-patients-is-mobile-health-mhealth-with-pedometer-more-effective-than-conventional-program-using-brochure
#14
Kyeong Eun Uhm, Ji Sung Yoo, Seung Hyun Chung, Jong Doo Lee, Ilkyun Lee, Joong Il Kim, Se Kyung Lee, Seok Jin Nam, Yong Hyun Park, Ji Youl Lee, Ji Hye Hwang
PURPOSE: To investigate and compare the effects of mobile health (mHealth) and pedometer with conventional exercise program using a brochure on physical function and quality of life (QOL). METHODS: The study was a prospective, quasi-randomized multicenter trial where 356 patients whose cancer treatment had been terminated were enrolled. All patients were instructed to perform a 12-week regimen of aerobic and resistance exercise. The mHealth group received a pedometer and a newly developed smartphone application to provide information and monitor the prescribed exercises...
December 8, 2016: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/27933410/magnetic-resonance-imaging-patterns-of-treatment-related-toxicity-in-the-pediatric-brain-an-update-and-review-of-the-literature
#15
REVIEW
Maria Camilla Rossi Espagnet, Luca Pasquini, Antonio Napolitano, Antonella Cacchione, Angela Mastronuzzi, Roberta Caruso, Paolo Tomà, Daniela Longo
Treatment-related neurotoxicity is a potentially life-threatening clinical condition that can represent a diagnostic challenge. Differentiating diagnoses between therapy-associated brain injury and recurrent disease can be difficult, and the immediate recognition of neurotoxicity is crucial to providing correct therapeutic management, ensuring damage reversibility. For these purposes, the knowledge of clinical timing and specific treatment protocols is extremely important for interpreting MRI patterns. Neuroradiologic findings are heterogeneous and sometimes overlapping, representing the compounding effect of the different treatments...
December 9, 2016: Pediatric Radiology
https://www.readbyqxmd.com/read/27933394/men-and-women-show-similar-survival-rates-after-breast-cancer
#16
Paulo Franscisco Mascarenhas Bender, Letícia Lima de Oliveira, Célia Regina Costa, Suzana Sales de Aguiar, Anke Bergmann, Luiz Claudio Santos Thuler
PURPOSE: To compare the disease-free survival (DFS) and overall survival (OS) rates of men and women undergoing treatment for breast cancer. METHODS: A retrospective cohort study of patients with breast cancer diagnosed and treated at the Cancer Hospital III of the National Cancer Institute of Brazil, Rio de Janeiro, Brazil, between 1999 and 2013. Male breast cancer cases were matched for age, year of diagnosis, and clinical staging to three female cases (1:3). Patient characteristics were abstracted from hospital records and medical charts...
December 8, 2016: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/27932889/alveolar-rhabdomyosarcoma-of-the-sphenoid-sinus-mimicking-optic-neuritis-presenting-with-intermittent-visual-loss-in-an-adult
#17
Wendong Liu, Libin Jiang, Yulan Jin, Bentao Yang, Timothy Yy Lai
A 23-year-old male with intermittent visual loss in his left eye for 4 months was originally treated as optic neuritis elsewhere. Upon presentation to our hospital (Beijing Tongren Hospital), his left eye visual acuity was reduced to hand motion at face. The left eye ocular motility was limited in upgaze, downgaze, adduction, and abduction. Computed tomography and magnetic resonance imaging revealed lesions in the sphenoid and ethmoid sinuses, orbital apex and carvernous sinus invading adjacent extraocular muscles...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27932539/assessment-of-concomitant-versus-sequential-trastuzumab-on-radiation-induced-cardiovascular-toxicity
#18
G Yavas, M Gultekin, O Yildiz, M Seyrek, S Demirkol, H Toy, M F Sargon, O Ozkayar, A Uner, F Yildiz, F Akyol
There are limited data regarding effect of trastuzumab on radiation-induced cardiovascular toxicity when used sequentially or concomitantly. This experimental study aims to investigate effect of trastuzumab on radiation-induced cardiovascular toxicity with respect to the treatment sequence. One hundred and eight female Wistar albino rats were divided into six groups (G): G1 was control, G2 was trastuzumab, and G3 was radiotherapy (RT); G4 and G6 were sequential RT and trastuzumab; and G5 was concomitant RT and trastuzumab groups, respectively...
December 8, 2016: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/27932528/comorbidities-treatment-patterns-and-cost-of-illness-of-acromegaly-in-sweden-a-register-linkage-population-based-study
#19
Eva Lesén, Daniel Granfeldt, Aude Houchard, Jérôme Dinet, Anthony Berthon, Daniel S Olsson, Ingela Björholt, Gudmundur Johannsson
OBJECTIVE: Acromegaly is a complex endocrine disease with multiple comorbidities. Treatment to obtain biochemical remission includes surgery, medical therapy and radiation. We aimed to describe comorbidities, treatment patterns and cost-of-illness in patients with acromegaly in Sweden. DESIGN: A nationwide population-based study. METHODS: Patients with acromegaly were identified and followed in national registers in Sweden. Longitudinal treatment patterns were assessed in patients diagnosed between July 2005 and December 2013...
February 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/27932443/pd-l1-blockade-enhances-response-of-pancreatic-ductal-adenocarcinoma-to-radiotherapy
#20
Abul Azad, Su Yin Lim, Zenobia D'Costa, Keaton Jones, Angela Diana, Owen J Sansom, Philipp Kruger, Stanley Liu, W Gillies McKenna, Omer Dushek, Ruth J Muschel, Emmanouil Fokas
Pancreatic ductal adenocarcinoma (PDAC) is considered a non-immunogenic tumor, and immune checkpoint inhibitor monotherapy lacks efficacy in this disease. Radiotherapy (RT) can stimulate the immune system. Here, we show that treatment of KPC and Pan02 murine PDAC cells with RT and gemcitabine upregulated PD-L1 expression in a JAK/Stat1-dependent manner. In vitro, PD-L1 inhibition did not alter radio- and chemosensitivity. In vivo, addition of anti-PD-L1 to high (12, 5 × 3, 20 Gy) but not low (6, 5 × 2 Gy) RT doses significantly improved tumor response in KPC and Pan02 allografts...
December 8, 2016: EMBO Molecular Medicine
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