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https://www.readbyqxmd.com/read/25646088/dense-fibrillar-collagen-is-a-potent-inducer-of-invadopodia-via-a-specific-signaling-network
#1
Vira V Artym, Stephen Swatkoski, Kazue Matsumoto, Catherine B Campbell, Ryan J Petrie, Emilios K Dimitriadis, Xin Li, Susette C Mueller, Thomas H Bugge, Marjan Gucek, Kenneth M Yamada
Cell interactions with the extracellular matrix (ECM) can regulate multiple cellular activities and the matrix itself in dynamic, bidirectional processes. One such process is local proteolytic modification of the ECM. Invadopodia of tumor cells are actin-rich proteolytic protrusions that locally degrade matrix molecules and mediate invasion. We report that a novel high-density fibrillar collagen (HDFC) matrix is a potent inducer of invadopodia, both in carcinoma cell lines and in primary human fibroblasts. In carcinoma cells, HDFC matrix induced formation of invadopodia via a specific integrin signaling pathway that did not require growth factors or even altered gene and protein expression...
February 2, 2015: Journal of Cell Biology
https://www.readbyqxmd.com/read/25173804/diverse-functions-of-kindlin-fermitin-proteins-during-embryonic-development-in-xenopus-laevis
#2
Tania Rozario, Paul E Mead, Douglas W DeSimone
The kindlin/fermitin family includes three proteins involved in regulating integrin ligand-binding activity and adhesion. Loss-of-function mutations in kindlins1 and 3 have been implicated in Kindler Syndrome and Leukocyte Adhesion Deficiency III (LAD-III) respectively, whereas kindlin2 null mice are embryonic lethal. Post translational regulation of cell-cell and cell-ECM adhesion has long been presumed to be important for morphogenesis, however, few specific examples of activation-dependent changes in adhesion molecule function in normal development have been reported...
August 2014: Mechanisms of Development
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