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indiopathic interstitial pneumonias

Edwin Roger Parra, Ligia Rodrigues Silvério da Costa, Alexandre Ab'Saber, Carlos Roberto Ribeiro de Carvalho, Ronaldo Adib Kairalla, Sandra Moraes Fernezlian, Lisete R Teixeira, Vera Luiza Capelozzi
Integrin-immunoglobulin family ligand (CAMs) interactions between lung parenchymal cells (fibroblasts and epithelial cells) and integrin-extracellular matrix component interactions may be involved in the pathogenesis of idiopathic interstitial pneumonia (IIP). Among these, CD34 immunoquantitation allows determination of the degree of vascular proliferation (angiogenesis), whereas VCAM-1 immunoquantitation allows evaluation of the degree of endothelial activity and is strong evidence of inflammation. To validate the importance of vascular proliferation and endothelial cell activity within the alveolar walls and to explore the quantitative relationship between this factor and organizing fibrosis after parenchymal remodeling, we studied surgical lung biopsies in major IIP histologic patterns...
September 2005: Lung
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