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Brain tumor AND respiratory

Alexander N Shikov, Olga N Pozharitskaya, Valery G Makarov
PURPOSE: Aralia elata var. mandshurica (Rupr. & Maxim.) J.Wen syn. A. mandshurica Rupr. & Maxim is evaluated for its medicinal application. The aim of this study is to analyze pharmacological studies on A. elata var. mandshurica published until December 2015. METHODS: The information regarding the chemistry, safety, effectiveness, and pharmacological and clinical effects of A. elata was systematically collected from the scientific literature through library catalogs; online services such as E-library...
November 15, 2016: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
David J Cote, Heloise M Dubois, Aditya V Karhade, Timothy R Smith
Background Patients who undergo craniotomy for brain tumor have an increased risk of developing venous thromboembolism (VTE). Using the National Surgical Quality Improvement Program (NSQIP) registry, patients undergoing craniotomy for brain tumor from 2006 and 2014 were analyzed to identify risk factors for postoperative VTE. Methods The study population, identified by Current Procedural Terminology codes, included all NSQIP-reported patients who underwent a craniotomy for brain tumor resection. Results There were 629 instances of VTE among 19,409 craniotomies for brain tumor (3...
October 20, 2016: Seminars in Thrombosis and Hemostasis
J H Tapia-Pérez, D Karagianis, R Zilke, V Koufuglou, I Bondar, T Schneider
OBJECTIVE: After spontaneous intracerebral hemorrhage (ICH) a local and systemic inflammatory response is activated. Interleukin-6 (IL) is one of most relevant orchestrators of inflammatory responses in the brain and is released from multiple immune cells, including neutrophils. Herby we assessed the relevance of systemic inflammation in patients suffering ICH. METHODS: From October 2010 to October 2011 we included in our routine of laboratory investigations besides to C-reactive protein (CRP), the addition of IL-6 and an analysis of the subpopulation of circulating blood cells...
November 2016: Clinical Neurology and Neurosurgery
Melanie Lohrberg, Jörg Wilting
Histological studies of the lymphatic vascular system in adult mice are hampered because bones cannot be sectioned properly. Here, we decalcified the heads of 14-day-old mice, embedded them in paraffin and stained resultant serial sections with the lymphendothelial-specific antibodies Lyve-1 and Podoplanin. We show that the tissues with the highest lymphatic vascular density are the dermis and the oral mucous membranes. In contrast, the nasal mucous membrane is devoid of lymphatics, except for its most basal parts below the vomeronasal organ...
September 6, 2016: Cell and Tissue Research
Krishna M Talasila, Gro V Røsland, Hanne R Hagland, Eskil Eskilsson, Irene H Flønes, Sabrina Fritah, Francisco Azuaje, Nadia Atai, Patrick N Harter, Michel Mittelbronn, Michael Andersen, Justin V Joseph, Jubayer Al Hossain, Laurent Vallar, Cornelis J F van Noorden, Simone P Niclou, Frits Thorsen, Karl Johan Tronstad, Charalampos Tzoulis, Rolf Bjerkvig, Hrvoje Miletic
BACKGROUND: Invasion and angiogenesis are major hallmarks of glioblastoma (GBM) growth. While invasive tumor cells grow adjacent to blood vessels in normal brain tissue, tumor cells within neovascularized regions exhibit hypoxic stress and promote angiogenesis. The distinct microenvironments likely differentially affect metabolic processes within the tumor cells. METHODS: In the present study, we analyzed gene expression and metabolic changes in a human GBM xenograft model that displayed invasive and angiogenic phenotypes...
September 3, 2016: Neuro-oncology
Tomohito Hagi, Tomoki Nakamura, Ayumu Yokoji, Akihiko Matsumine, Akihiro Sudo
The present study reports a case of medullary metastasis without lung metastasis that occurred as a result of a malignant peripheral nerve sheath tumor (MPNST). An 81-year-old woman presented with a MPNST in the left brachial plexus, arising from the cervical nerve root. The patient underwent carbon ion radiotherapy; however, tumor recurrence was identified in the left shoulder. Subsequently, the patient underwent wide excision. Three weeks subsequent to surgery, imbalance and dysarthria developed suddenly...
September 2016: Oncology Letters
Shan Ren, Xia Chen, Li Jiang, Bo Zhu, Qi Jiang, Xiuming Xi
Acute respiratory distress syndrome (ARDS) is associated with high mortality and morbidity. Early diagnosis and risk stratification in patients with ARDS should improve prognosis. Unfortunately, no clinical biomarkers are available for use in early diagnosis. Quantitative proteomics is a powerful tool for biomarker discovery in cancer, autoimmune diseases, and ARDS. Here, we employed isobaric tags for relative and absolute quantitation (iTRAQ) technology to identify potential biomarkers for early ARDS diagnosis and predict the risk for increased disease severity induced by pneumonia...
September 23, 2016: Biochemical and Biophysical Research Communications
Albrecht Günther, Julia Schubert, Dirk Brämer, Otto Wilhelm Witte
Autoimmune encephalitis, an inflammatory disease of the brain, is usually attributed to antibody-mediated damage and dysfunction of neuronal structures. A distinction is made between onconeuronal antibodies (directed against intracellular neuronal antigens with resulting paraneoplastic neurological syndromes) and antibodies directed against neuronal cell surface proteins (with resulting synaptic encephalopathies). Anti-NMDA-Receptor-Encephalitis, the most common form of autoimmune encephalopathy, is characterized by a phased course of disease...
August 2016: Deutsche Medizinische Wochenschrift
Andrej Fabrizius, Daniel Andre, Tilmann Laufs, Anne Bicker, Stefan Reuss, Elena Porto, Thorsten Burmester, Thomas Hankeln
Neuroglobin (Ngb) is a respiratory protein that is almost exclusively expressed in the vertebrate nervous system. Despite many years of research, the exact function and even the expression sites of Ngb are still a matter of debate. However, to investigate hypotheses surrounding the potential roles of Ngb, a detailed knowledge of its major and minor expression sites is indispensable. We have therefore evaluated Ngb expression by extensive bioinformatic analysis using publicly available transcriptome data (RNA-Seq)...
August 16, 2016: Neuroscience
Wmr Ashour, A D Al-Anwar, A E Kamel, M A Aidaros
BACKGROUND: Infection is the most common complication of stroke. AIM: To determine the risk factors and predictors of post-stroke infection (PSI), which developed within 7 days from the onset of acute ischemic stroke. SUBJECTS: The study included 60 ischemic stroke patients admitted in the Neurology Department of Zagazig University, Egypt, who were subdivided into: [Non Stroke Associated Infection group (nSAI); 30 patients having stroke without any criteria of infection within 7 days from the onset and Stroke Associated Infection group (SAI); 30 patients having stroke with respiratory tract infection (RTI) or urinary tract infection within 7 days], in addition to 30 healthy sex and age-matching subjects as control...
April 2016: Journal of Medicine and Life
Llewellyn Padayachy, Graham A G Fieggen
INTRODUCTION: Reliable assessment of intracranial pressure (ICP) remains crucial in managing neurosurgical conditions in children. The present study examined the relationship between transorbital ultrasound measurement of the optic nerve sheath diameter (ONSD) and invasively measured ICP in children. METHODS: This was a prospective, observational study comparing ONSD measurement with invasive ICP measurement. All patients were under general anesthesia and physiological variables, including systolic and diastolic blood pressure, mean arterial pressure, pulse rate, temperature, respiratory rate, and end-tidal carbon dioxide level, were recorded at the time of ONSD measurement...
August 2016: Neurosurgery
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No abstract text is available yet for this article.
June 2016: Annals of Intensive Care
Dildar Hussain Kalhoro, Shanshan Gao, Xing Xie, Shan Liang, Su Luo, Yanbing Zhao, Yongjie Liu
BACKGROUND: Canine influenza virus (CIV) and Staphylococcus pseudintermedius (Sp) are pathogens that cause respiratory disease in dogs. Considering bacterial infections following influenza are a leading cause of illness and death, it is of particular meaning to investigate the interaction between these two pathogens. In this study, BALB/c mice were used as a mouse model to assess whether inoculation with CIV H3N2 followed by S. pseudintermedius 72 h later resulted in exacerbation of disease...
2016: BMC Veterinary Research
Iris A L M van Rooij, Loes F M van der Zanden, Ernie M H F Bongers, Kirsten Y Renkema, Charlotte H W Wijers, Michelle Thonissen, Elisabeth M J Dokter, Carlo L M Marcelis, Ivo de Blaauw, Marc H W A Wijnen, Peter M Hoogerbrugge, Jos P M Bokkerink, Michiel F Schreuder, Linda Koster-Kamphuis, Elisabeth A M Cornelissen, Livia Kapusta, Arno F J van Heijst, Kian D Liem, Robert P E de Gier, Anne Marie Kuijpers-Jagtman, Ronald J C Admiraal, Stefaan J Bergé, Jan Jaap van der Biezen, An Verdonck, Vincent Vander Poorten, Greet Hens, Jasmien Roosenboom, Marc R Lilien, Tom P de Jong, Paul Broens, Rene Wijnen, Alice Brooks, Barbara Franke, Han G Brunner, Carine E L Carels, Nine V A M Knoers, Wout F J Feitz, Nel Roeleveld
BACKGROUND: Research regarding the etiology of birth defects and childhood cancer is essential to develop preventive measures, but often requires large study populations. Therefore, we established the AGORA data- and biobank in the Netherlands. In this study, we describe its rationale, design, and ongoing data collection. METHODS: Children diagnosed with and/or treated for a structural birth defect or childhood cancer and their parents are invited to participate in the AGORA data- and biobank...
August 2016: Birth Defects Research. Part A, Clinical and Molecular Teratology
Seungjoo Lee, Go Woon Jun, Sang Beom Jeon, Chang Jin Kim, Jeong Hoon Kim
Severe paroxysmal sympathetic overactivity occurs in a subgroup of patients with acquired brain injuries including traumatic brain injury, hypoxia, infection and tumor-related complications. This condition is characterized by sudden increase of heart rate, respiratory rate, blood pressure, body temperature and excessive diaphoresis. The episodes may be induced by external stimulation or may occur spontaneously. Frequent occurrence of this condition could result in secondary morbidities, therefore, should be diagnosed and managed insightfully...
2016: SpringerPlus
Kota Ohashi, Makiko Kayama, Shoko Ryuuo, Jun Suzuki, Yutaka Hayashinoshita, Shiho Ooka, Rie Matsuura
INTRODUCTION: We provided home end-of-life care to a child with a brain tumor. As cases of children with malignancies who receive such care have rarely been described in Japan, we report our experience with this patient. CASE REPORT: An 11-year-old previously healthy boy was found to have a brainstem glioma in December X. The tumor was reduced by radiotherapy and chemotherapy, but relapse was noted in August X plus 1. Best supportive care alone was selected for this patient...
December 2015: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Zhijie Pan, Zhou An, Yanyuan Li, Jianying Zhou
Angiosarcoma is a rare, heterogeneous malignant tumor that derives from endothelial cells, and it has aggressive characteristics with a marked tendency for distant metastasis. Diffuse alveolar hemorrhage (DAH) is a catastrophic clinical syndrome, however, it is rare as the presentation of pulmonary angiosarcoma. To increase awareness with regard to angiosarcoma and DAH, the current study presents a case of angiosarcoma that originated from the subcutaneous soft tissue of the mastoid process, but was subject to a delayed diagnosis and rapid invasion into the brain and lung...
December 2015: Oncology Letters
Tasuku Sano, Hisashi Uhara, Yasutomo Mikoshiba, Aya Kobayashi, Ryuhei Uchiyama, Kazunari Tateishi, Hiroshi Yamamoto, Ryuhei Okuyama
We report the case of a 70-year-old woman with vaginal melanoma and multiple metastases in the lung. After the third dose of nivolumab, decreased room-air resting arterial oxygen saturation with bilateral basal fine crackles on auscultation developed despite the absence of respiratory symptoms. Computed tomography showed ground-glass opacities with airspace consolidations scattered with a peculiar distribution, and most were observed around the existing metastatic tumors in the lung. From the 42nd day to the 56th day after the last administration of nivolumab, she received dexamethasone 1-2 mg/body for the prevention of adverse events after stereotactic radiation for brain metastasis...
March 2016: Japanese Journal of Clinical Oncology
Xu Zhi Peng, Li Hong Hua, Sun Zhi Qiang, Wu Qiang
CONTEXT: Tumor-like inflammatory demyelinating disease (TIDD) usually occurs in the brain and rarely occurs in the spinal cord. TIDD appears to be very similar to tumors such as gliomas on imaging, which may lead to incorrect or delayed diagnosis and treatment. CASE REPORT: Because of headache and incoherent speech, a 24-year-old Chinese male presented to our hospital with a two-week history of respiratory infections. After dexamethasone treatment, his symptoms still got worse and surgery was performed for diagnostic purposes...
September 2015: São Paulo Medical Journal, Revista Paulista de Medicina
Qian Wu, B O Xiao, L I Li, L I Feng
Atypical teratoid/rhabdoid tumor (AT/RT) is an aggressive embryonic brain tumor that is predominantly found in young children. The present study reports the unusual case of an adult male AT/RT patient with a history of another type of tumor, hereditary multiple exostoses (EXT or HME), who survived for 18 years. The patient's first and chief complaint was a 1-month history of progressive projectile vomiting. The patient was admitted twice for treatment, and on the second admission, a craniotomy was performed to remove a intracranial mass...
September 2015: Oncology Letters
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