Dorsa Vatandoust, Houssein Ahmadi, Abdollah Amini, Atarodalsadat Mostafavinia, Fatemeh Fadaei Fathabady, Ali Moradi, Mohammadjavad Fridoni, Michael R Hamblin, Roohollah Ebrahimpour-Malekshah, Sufan Chien, Mohammad Bayat
In this preclinical investigation, we examined the effects of combining preconditioned diabetic adipose-derived mesenchymal stem cells (AD-MSCs) and photobiomodulation (PBM) on a model of infected ischemic delayed healing wound (injury), (IIDHWM) in rats with type I diabetes (TIDM). During the stages of wound healing, we examined multiple elements such as stereology, macrophage polarization, and the mRNA expression levels of stromal cell-derived factor (SDF)-1α, vascular endothelial growth factor (VEGF), hypoxia-induced factor 1α (HIF-1α), and basic fibroblast growth factor (bFGF) to evaluate proliferation and inflammation...
March 5, 2024: Lasers in Medical Science