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https://www.readbyqxmd.com/read/29149622/the-chemokine-receptor-type-4-antagonist-amd3100-interrupts-experimental-tooth-movement-in-rats
#1
Kasumi Hatano, Yuji Ishida, Hiroyuki Yamaguchi, Jun Hosomichi, Jun-Ichi Suzuki, Risa Usumi-Fujita, Yasuhiro Shimizu, Naoki Shibutani, Sawa Kaneko, Takashi Ono
OBJECTIVE: The aim of this study was to clarify the role of the stromal cell-derived factor-1 (SDF-1)/C-X-C chemokine receptor type 4 (CXCR4) axis in osteoclast accumulation, and the influence of orthodontic tooth movement (OTM) under mechanical force application to periodontal tissues, by administration of the CXCR4 antagonist AMD3100. DESIGN: The upper right first molar (M1) of rats was moved mesially with a 10-g force titanium-nickel closed coil spring. Rats were treated with phosphate-buffered saline or AMD3100 (5mg/kg), which is a SDF-1 antagonist...
November 11, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/29147957/mobilization-of-endothelial-progenitor-cell-in-patients-with-acute-ischemic-stroke
#2
Yushuang Deng, Jian Wang, Guiqiong He, Fei Qu, Min Zheng
Endothelial progenitor cells (EPCs) have important effect in tissue repair in ischemic organs. The present study was conducted to demonstrate the mobilization of EPCs and its possible mechanism after acute ischemic stroke (AIS). A total of 148 individuals were examined, including 106 patients with ischemic stroke and 42 healthy controls. Seventy-one patients with imaging-confirmed AIS were examined at days 1, 7, 14, and 21 after stroke onset. Circulating EPCs were quantified by flow cytometry using CD133 and KDR surface markers...
November 16, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/29146732/mir-539-5p-inhibits-experimental-choroidal-neovascularization-by-targeting-cxcr7
#3
Yifan Feng, Jing Wang, Yuanzhi Yuan, Xi Zhang, Minqian Shen, Fei Yuan
Stromal cell-derived factor-1 (SDF-1) has been previously confirmed to participate in the formation of choroidal neovascularization (CNV) via its receptor, CXC chemokine receptor (CXCR) 4; CXCR7 is a recently identified receptor for SDF-1. The molecular mechanisms and therapeutic value of CXCR7 in CNV remain undefined. In this study, experimental CNV was induced by laser photocoagulation in Brown-Norway pigmented rats, and aberrant CXCR7 overexpression was detected in the retinal pigment epithelial/choroid/sclera tissues of laser-injured eyes...
November 16, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29130552/resveratrol-pretreatment-enhanced-homing-of-sdf-1%C3%AE-preconditioned-bone-marrow-derived-mesenchymal-stem-cells-in-a-rat-model-of-liver-cirrhosis
#4
Mehrdad Hajinejad, Parichehr Pasbakhsh, Ameneh Omidi, Keywan Mortezaee, Saied Nekoonam, Reza Mamoudi, Iraj Ragerdi Kashani
Stromal cell-derived factor-1α (SDF-1α) has been known to implicate in homing of MSCs, and resveratrol has been reported to have a positive influence on SDF-1 level in the site of injury. In this study, a combined strategy was applied to evaluate bone marrow-derived MSCs (BMSCs) homing to the rat model of liver cirrhosis induced by common bile duct ligation (CBDL): (1) pretreatment delivery of resveratrol into the cirrhotic liver, and (2) transplantation of ex vivo BMSC preconditioning with SDF-1α. BMSCs were preconditioned with 10 ng/μl SDF-1α for 1h and then labelled with the CM-Dil...
November 11, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29123467/the-role-of-sdf-1-cxcr4-cxcr7-in-neuronal-regeneration-after-cerebral-ischemia
#5
REVIEW
Xi Cheng, Huibin Wang, Xiuchun Zhang, Shanshan Zhao, Zhike Zhou, Xiaopeng Mu, Chuansheng Zhao, Weiyu Teng
Stromal cell-derived factor-1 is a chemoattractant produced by bone marrow stromal cell lines. It is recognized as a critical factor in the immune and central nervous systems (CNSs) as well as exerting a role in cancer. SDF-1 activates two G protein-coupled receptors, CXCR4 and CXCR7; these are expressed in both developing and mature CNSs and participate in multiple physiological and pathological events, e.g., inflammatory response, neurogenesis, angiogenesis, hematopoiesis, cancer metastasis, and HIV infection...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29119710/role-of-sdf-1-cxcr4-in-impaired-post-myocardial-infarction-cardiac-repair-in-diabetes
#6
Maritza E Mayorga, Matthew Kiedrowski, Patricia McCallinhart, Farhad Forudi, Jeremiah Ockunzzi, Kristal Weber, William Chilian, Marc S Penn, Feng Dong
Diabetes is a risk factor for worse outcomes following acute myocardial infarction (AMI). In this study, we tested the hypothesis that SDF-1:CXCR4 expression is compromised in post-AMI in diabetes, and that reversal of this defect can reverse the adverse effects of diabetes. Mesenchymal stem cells (MSC) isolated from green fluorescent protein (GFP) transgenic mice (control MSC) were induced to overexpress stromal cell-derived factor-1 (SDF-1). SDF-1 expression in control MSC and SDF-1-overexpressing MSC (SDF-1:MSC) were quantified using enzyme-linked immunosorbent assay (ELISA)...
November 9, 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/29111236/reprint-of-dual-blockade-of-the-pro-inflammatory-chemokine-ccl2-and-the-homeostatic-chemokine-cxcl12-is-as-effective-as-high-dose-cyclophosphamide-in-murine-proliferative-lupus-nephritis
#7
Satish Kumar Devarapu, Santhosh Kumar Vr, Khader Valli Rupanagudi, Onkar P Kulkarni, Dirk Eulberg, Sven Klussmann, Hans-Joachim Anders
Induction therapy of proliferative lupus nephritis still requires the use of unselective immunosuppressive drugs with significant toxicities. In search of more specific drugs with equal efficacy but fewer side effects we considered blocking pro-inflammatory chemokine monocyte chemoattractant protein-1 (MCP-1/CCL2) and homeostatic chemokine stromal cell-derived factor-1 (SDF-1/CXCL12), which both contribute to the onset and progression of proliferative lupus nephritis yet through different mechanisms. We hypothesized that dual antagonism could be as potent on lupus nephritis as the unselective immunosuppressant cyclophosphamide (CYC)...
October 27, 2017: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/29106576/the-stromal-cell-derived-factor-1-c-x-c-chemokine-receptor-type-4-axis-is-important-in-neutrophil-migration-caused-by-cardiopulmonary-bypass-in-children
#8
Ran Tu, Yanhua Peng, Ying Wang, Xixi Tang, Shouyong Wang
OBJECTIVES: Acute lung injury caused by cardiopulmonary bypass (CPB) is characterized by massive neutrophil migration to the lungs. Neutrophil migration may be closely related to stromal cell-derived factor 1 (SDF-1)/C-X-C chemokine receptor Type 4 (CXCR4) axis activation, which plays an essential role in modulating the trafficking of neutrophils. We investigated the changes in the expression of SDF-1/CXCR4 axis components before and after CPB as well as the role of the axis in driving the migration of neutrophils in patients with congenital heart disease...
November 2, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29098000/pro-inflammatory-state-in-monoclonal-gammopathy-of-undetermined-significance-and-in-multiple-myeloma-is-characterized-by-low-sialylation-of-pathogen-specific-and-other-monoclonal-immunoglobulins
#9
Adrien Bosseboeuf, Sophie Allain-Maillet, Nicolas Mennesson, Anne Tallet, Cédric Rossi, Laurent Garderet, Denis Caillot, Philippe Moreau, Eric Piver, François Girodon, Hélène Perreault, Sophie Brouard, Arnaud Nicot, Edith Bigot-Corbel, Sylvie Hermouet, Jean Harb
Multiple myeloma (MM) and its pre-cancerous stage monoclonal gammopathy of undetermined significance (MGUS) allow to study immune responses and the chronology of inflammation in the context of blood malignancies. Both diseases are characterized by the production of a monoclonal immunoglobulin (mc Ig) which for subsets of MGUS and MM patients targets pathogens known to cause latent infection, a major cause of inflammation. Inflammation may influence the structure of both polyclonal (pc) Ig and mc Ig produced by malignant plasma cells via the sialylation of Ig Fc fragment...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29096843/h-e-l-p-apheresis-exerts-long-term-effects-on-the-capacity-of-circulating-proangiogenic-cells
#10
Jan Sradnick, Sergey Tselmin, Andrea Wagner, Ulrich Julius, Vladimir Todorov, Christian Hugo, Bernd Hohenstein
BACKGROUND: Severe forms of mono- and polygenetic hypercholesterolemia as well as elevated Lipoprotein (a) (LP(a)) with progressing cardiovascular (CV) disease are indication for lipoprotein apheresis (LA) in Germany. Many studies investigated pleiotropic effects of LA that might contribute to beneficial effects in advanced atherosclerosis. The present study aimed at investigating the potential role of Proangiogenic Cells (PAC) in patients with new onset or chronic LA using the heparin induced extracorporeal LDL-precipitation (H...
November 2017: Atherosclerosis. Supplements
https://www.readbyqxmd.com/read/29078859/corrigendum-to-curcumin-exhibits-anti-tumor-effect-and-attenuates-cellular-migration-via-slit-2-mediated-down-regulation-of-sdf-1-and-cxcr4-in-endometrial-adenocarcinoma-cells-j-nutr-biochem-44-2017-60-70
#11
Vijay Kumar Sirohi, Pooja Popli, Pushplata Sankhwar, Jyoti Bala Kaushal, Kanchan Gupta, Murli Manohar, Anila Dwivedi
No abstract text is available yet for this article.
November 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29061521/effect-of-heparan-sulfate-mimetics-from-escherichia-coli-k5-polysaccharide-on-sdf-1-cxcl12-induced-endothelial-progenitor-cells-in-vitro
#12
Haitian Fu, Chao Deng, Liping Teng, Zhi Cai, Jinghua Chen, Guozhong Lu
In tumorigenesis, CXCL12 level increases sharply because of tumor tissue hypoxia. As CXCR4 cells, endothelial progenitor cells (EPCs) are mobilized to tumor bed through the CXCL12/CXCR4 axis and are involved in tumor angiogenesis. In this process, either glycosaminoglycan (GAG) or heparan sulfate (HS) carried by membrane proteoglycans is implicated. Exogenous soluble HS mimetics can act as a competitive inhibitor of membranous HS, thereby preventing the formation of a normal signal axis. In this work, the effect of HS mimetics on the CXCL12-induced EPCs in vitro was investigated...
October 20, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29061496/sdf-1-cxcr4-expression-is-an-independent-negative-prognostic-biomarker-in-patients-with-head-and-neck-cancer-after-primary-radiochemotherapy
#13
Chiara De-Colle, Apostolos Menegakis, David Mönnich, Stefan Welz, Simon Boeke, Bence Sipos, Falko Fend, Paul-Stefan Mauz, Inge Tinhofer, Volker Budach, Jehad Abu Jawad, Martin Stuschke, Panagiotis Balermpas, Claus Rödel, Anca-Ligia Grosu, Amir Abdollahi, Jürgen Debus, Claus Belka, Ute Ganswindt, Steffi Pigorsch, Stephanie E Combs, Fabian Lohaus, Annett Linge, Mechthild Krause, Michael Baumann, Daniel Zips
INTRODUCTION: Preclinical and clinical data suggest that the chemokine pathway governed by SDF-1 and CXCR4 contributes to a resistant phenotype. This retrospective biomarker study aims to explore the specific prognostic value of SDF-1 and CXCR4 expression in locally advanced head and neck squamous cell carcinomas (HNSCC) treated with primary radiochemotherapy (RT-CT). MATERIAL AND METHODS: Biopsies from 141 HNSCC tumours of the oral cavity, oropharynx and hypopharynx were evaluated for SDF-1 and CXCR4 expression by immunofluorescence...
October 20, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29037917/immunomodulation-after-radiofrequency-ablation-of-locally-advanced-pancreatic-cancer-by-monitoring-the-immune-response-in-10-patients
#14
Alessandro Giardino, Giulio Innamorati, Stefano Ugel, Omar Perbellini, Roberto Girelli, Isabella Frigerio, Paolo Regi, Filippo Scopelliti, Giovanni Butturini, Salvatore Paiella, Matilde Bacchion, Claudio Bassi
OBJECTIVE/BACKGROUND: RFA of pancreatic cancer has been demonstrated to be feasible and safe with a positive impact on survival. The aim was to investigate whether an immune reaction is activated after locally advanced pancreatic cancer (LAPC) ablation. METHODS: Peripheral Blood samples were obtained preoperatively and on post-operative days 3-30. Evaluated parameters were: cells [CD4(+), CD8(+) and activated subsets, T-Reg, Monocytes, myeloid and plasmocytoid Dendritic cells (mDC and pDC)] and cytokines [Interleukin (IL)-6, Stromal-cells derived factor (SDF)-1, IL-1β, Tumour-Necrosis Factor (TNF)-α, Interferon (IFN)-γ, Vascular Endothelial Growth Factor (VEGF), chemokine (C-C motif) ligand 5 (CCL-5), Transforming-Growth Factor (TGF)-β]...
September 27, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/29026158/ginsenoside-rb1-prevents-homocysteine-induced-epc-dysfunction-via-vegf-p38mapk-and-sdf-1-cxcr4-activation
#15
Tao-Hua Lan, Dan-Ping Xu, Man-Ting Huang, Ju-Xian Song, Huan-Lin Wu, Min Li
Hyperhomocystinemia (HHcy) is known as an independent risk factor for cardiovascular disease. Our previous study showed that ginsenoside Rb1, the major active constituent of ginseng, prevents homocysteine (Hcy)-induced endothelial damage. However, the role of ginsenoside Rb1 in Hcy-induced dysfunction in endothelial progenitor cells (EPCs) remains unknown. In the study, we found that ginsenoside Rb1 reversed the Hcy-induced impairment of adhesive and migratory ability in EPCs which were significantly abolished by CXCR4 antagonist AMD3100 and VEGFR2 inhibitor SU5416...
October 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29024311/collagen-inducing-biologization-of-prosthetic-material-for-hernia-repair-polypropylene-meshes-coated-with-polyp-collagen
#16
Maximilian Ackermann, Xiaohong Wang, Shunfeng Wang, Meik Neufurth, Heinz C Schröder, Friedrich-Eckart Isemer, Werner E G Müller
Prostethic mesh material such as nonabsorbable polypropylene used in open and laparoscopic hernia repair are characterized by controllable mechanical properties but may elicit undesirable physiological reactions due to the nonphysiological inert polymer material. We succeeded in developing a biocompatible coating for these meshes, based on a physiological inorganic polymer, polyphosphate (polyP) that is morphogenetically active and used as a metabolic energy source, and a collagen matrix. The polyP/collagen hydrogel material was prepared by a freeze-extraction method, with amorphous Ca-polyP microparticles...
October 10, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29017079/effects-of-the-fibrous-topography-mediated-macrophage-phenotype-transition-on-the-recruitment-of-mesenchymal-stem-cells-an-in%C3%A2-vivo-study
#17
Qiankun Zhang, Jin Wook Hwang, Joung-Hwan Oh, Chan Ho Park, Shin Hye Chung, Yun-Sil Lee, Jeong-Hwa Baek, Hyun-Mo Ryoo, Kyung Mi Woo
Host responses to a biomaterial critically influence its in vivo performance. Biomaterial architectures that can recruit endogenous host stem cells could be beneficial in tissue regeneration or integration. Here, we report that the fibrous topography of biomaterials promotes the recruitment of host mesenchymal stem cells (MSCs) by facilitating the macrophage phenotype transition from M1-to-M2. Electrospun poly (ε-caprolactone) fiber (PCL-fiber) films were implanted into the subcutaneous tissues of rats, and the response of host cells to the PCL-fiber was evaluated and compared with those of solid ones (PCL-solid)...
October 4, 2017: Biomaterials
https://www.readbyqxmd.com/read/28994112/celastrol-attenuates-pain-and-cartilage-damage-via-sdf-1-cxcr4-signalling-pathway-in-osteoarthritis-rats
#18
Weifeng Wang, Chengzhi Ha, Tao Lin, Dawei Wang, Yuanhe Wang, Mingzhi Gong
OBJECTIVES: Celastrol has attracted wide interests for its anticancer and anti-inflammation properties, and studies have demonstrated that celastrol negatively modulates the stromal cell-derived factor-1 (SDF-1) and receptor C-X-C chemokine receptor type 4 (CXCR4) signalling. We aim in this study to investigate the effects of celastrol in osteoarthritis (OA) in vivo and explored the underlying molecular mechanisms. METHODS: We established a monoiodoacetate (MIA)-induced rat OA model and evaluated the joint pain and cartilage damage with or without celastrol treatments...
October 10, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/28979687/activation-of-a2ar-attenuates-bleomycin-induced-pulmonary-fibrosis-via-the-sdf-1-cxcr4-axis-related-pathway
#19
Yanfan Chen, Xiaoming Yu, Yicheng He, Lin Zhang, Xiaoying Huang, Xiaomei Xu, Mayun Chen, Xiang Chen, Liangxing Wang
Previous studies in our lab have demonstrated that Adenosine A2a receptor (A2aR) gene-knockout mice were vulnerable to pulmonary fibrosis induced by bleomycin (BLM). Inhibition of the SDF-1/CXCR4 axis has been reported to protect the lungs from fibrogenesis in BLM-exposed mice. Little is yet known about the relationships between A2aR and the SDF-1/CXCR4 axis in idiopathic pulmonary fibrosis (IPF). This study probes the role of A2aR in the fibrotic process and explores the relationship between A2aR and the SDF-1/CXCR4 axis in BLM-induced pulmonary fibrosis in mice...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28978524/ring-finger-protein-113a-regulates-c-x-c-chemokine-receptor-type-4-stability-and-signaling
#20
Travis Lear, Sarah R Dunn, Alison C McKelvey, Aazrin Mir, John Evankovich, Bill B Chen, Yuan Liu
As an alpha-chemokine receptor specific for stromal-derived-factor-1 (SDF-1, also called CXCL12), CXCR4 plays a vital role in chemotactically attracting lymphocytes during inflammation. CXCR4 also regulates HIV infection due to its role as one of the chemokine co-receptors for HIV entry into CD4+ T cells. Chemokine receptors and their signaling pathways have been shown to be regulated by the process of ubiquitination, a post-translational modification, guided by ubiquitin E3 ligases, which covalently links ubiquitin chains to lysine residues within target substrates...
October 4, 2017: American Journal of Physiology. Cell Physiology
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