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https://www.readbyqxmd.com/read/28426786/t140-blocks-the-sdf-1-cxcr4-signaling-pathway-and-prevents-cartilage-degeneration-in-an-osteoarthritis-disease-model
#1
Kun Wang, Yanlin Li, Rui Han, Guofeng Cai, Chuan He, Guoliang Wang, Di Jia
Osteoarthritis (OA) is one of the most common diseases affecting older people; however, there remains no effective targeted drug to combat OA. The aims of this study were (1) to explore the effect of T140 in regulating degeneration of articular cartilage in vivo by targeted blocking of the SDF-1/CXCR4 signaling pathway, and (2) to provide experimental evidence for the development of a novel OA-targeted pharmacotherapy. Thirty-six healthy Hartley guinea pigs were randomly divided into three groups: a T140-treated group (n = 12), a phosphate buffer saline control group (n = 12) and an untreated control group (n = 12)...
2017: PloS One
https://www.readbyqxmd.com/read/28421531/retraction-note-to-sdf-1-cxcr4-axis-regulates-cell-cycle-progression-and-epithelial-mesenchymal-transition-via-up-regulation-of-survivin-in-glioblastoma
#2
Anyan Liao, Ranran Shi, Yuliang Jiang, Suqing Tian, Panpan Li, Fuxi Song, Yalan Qu, Jinna Li, Haiqin Yun, Xiangshan Yang
No abstract text is available yet for this article.
April 18, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28416884/determination-of-soluble-dietary-fibre-content-of-okara-treated-with-high-hydrostatic-pressure-and-enzymes-a-comparative-evaluation-of-two-methods-aoac-and-hplc-elsd
#3
E Pérez-López, I Mateos-Aparicio, P Rupérez
ABSTRACT: Okara is a promising by-product from soybean and a rich source of dietary fibre, chiefly insoluble (IDF). To increase its solubility and functionality, a treatment with high hydrostatic pressure (HHP) assisted by food grade enzymes -Ultraflo(®) L or Viscozyme(®) L- has been performed. To monitor the effectiveness, an analysis of dietary fibre, mainly the soluble fraction (SDF), was accomplished by the AOAC enzymatic-gravimetric method with dialysis followed by both, spectrophotometric methods and High Performance Liquid Chromatography with Evaporative Light Scattering Detector (HPLC-ELSD) analysis of the soluble fraction...
April 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28413458/mir-9-functions-as-a-tumor-inhibitor-of-cell-proliferation-in-epithelial-ovarian-cancer-through-targeting-the-sdf-1-cxcr4-pathway
#4
Lin He, Li Zhang, Mengfei Wang, Wenrong Wang
The current study aimed to investigate the potential role of miR-9 in the inhibition of ovarian cancer progression through the stromal cell-derived factor-1 (SDF-1)/ C-X-C chemokine receptor type 4 (CXCR4) pathway and to provide a theoretical basis for the diagnosis and treatment of ovarian cancer. Human ovarian cancer OVCAR-3 cells were transfected with miR-9 short hairpin RNA (shRNA). The effect of miR-9 on the mRNA expression levels of CXCR4 were analyzed using reverse transcription-quantitative polymerase chain reaction...
April 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28412763/altered-expression-of-sdf-1-and-cxcr4-during-fracture-healing-in-diabetes-mellitus
#5
Michio Arakura, Sang Yang Lee, Shunsuke Takahara, Etsuko Okumachi, Takashi Iwakura, Tomoaki Fukui, Kotaro Nishida, Masahiro Kurosaka, Ryosuke Kuroda, Takahiro Niikura
PURPOSE: Diabetes mellitus (DM) is known to impair fracture healing. The purpose of this study was to elucidate and compare the gene expression patterns and localization of stromal cell-derived factor 1 (SDF-1) and CXC chemokine receptor 4 (CXCR4) during fracture healing of the femur in rats with and without DM. METHODS: Closed transverse fractures were created in the femurs of rats equally divided into a DM group and control group; DM was induced by streptozotocin...
April 15, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28412671/role-of-sdf-1-and-cxcr4-in-the-proliferation-migration-and-invasion-of-cervical-cancer
#6
Chen Wang, Hailing Cheng, Yanyun Li
This study was to investigate the role of stromal cell-derived factor 1 (SDF-1) and its corresponding receptor CXCR4 in the proliferation, migration and invasion of cervical cancer HeLa cells. CXCR4 expression in HeLa cells was measured by flow cytometry and Western Blot. Role of SDF-1 and CXCR4 in the HeLa cells proliferation was measured by MTT. Role of SDF-1 and CXCR4 in the migration and invasion of HeLa cell was measured by Boyden chamber. High expression of CXCR4 was observed on the surface of HeLa cells...
November 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28408934/sdf-1-cxcr4-signaling-maintains-stemness-signature-in-mouse-neural-stem-progenitor-cells
#7
Shih-Yin Ho, Thai-Yen Ling, Hsing-Yu Lin, Jeffrey Tsai-Jui Liou, Fei-Chih Liu, I-Chun Chen, Sue-Wei Lee, Yu Hsu, Dar-Ming Lai, Horng-Huei Liou
SDF-1 and its primary receptor, CXCR4, are highly expressed in the embryonic central nervous system (CNS) and play a crucial role in brain architecture. Loss of SDF-1/CXCR4 signaling causes abnormal development of neural stem/progenitor cells (NSCs/NPCs) in the cerebellum, hippocampus, and cortex. However, the mechanism of SDF-1/CXCR4 axis in NSCs/NPCs regulation remains unknown. In this study, we found that elimination of SDF-1/CXCR4 transduction caused NSCs/NPCs to lose their stemness characteristics and to encounter neurogenic differentiation...
2017: Stem Cells International
https://www.readbyqxmd.com/read/28402961/combination-of-susceptibility-gene-and-traditional-risk-factors-might-enhance-the-performance-of-coronary-heart-disease-screening-strategy
#8
Shiyan Nian, Lei Feng, Yang Zhao, Feng Luo, Shu Zhang, Dan Li, Wenbo Xu, Xingfeng Zhang, Dan Ye, Xuejing Bai
Coronary heart disease (CHD) associated risk factors and susceptibility genes were studied in parallel for decades, however, the combination of the classic CHD risk factors and genetic risk factors has been rarely studied. Previously; we reported that a single nucleotide polymorphism (SNP) in the stromal cell-derived factor 1 (SDF-1) gene was associated with CHD risk; in addition, we also established a CHD screening strategy using traditional CHD risk factors as independent variables. To explore how to combine genetic factors and traditional risk factors in CHD screening strategy, the CHD probabilities were tested in 218 males and 121 females according to their stromal cell-derived factor 1 (SDF-1) genotypes using CHD screening equations we reported previously...
March 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28402926/curcumin-exhibits-anti-tumor-effect-and-attenuates-cellular-migration-via-slit-2-mediated-down-regulation-of-sdf-1-and-cxcr4-in-endometrial-adenocarcinoma-cells
#9
Vijay Kumar Sirohi, Pooja Popli, Pushplata Sankhwar, Jyoti Bala Kaushal, Kanchan Gupta, Murli Manohar, Anila Dwivedi
Although curcumin shows anti-proliferative and anti-inflammatory activities in various cancers, the effect of curcumin on cellular migration in endometrial adenocarcinoma cells remains to be understood. The current investigation was aimed to explore the anti-proliferative and anti-migratory effects of curcumin and its mechanism of action in endometrial cancer cells. Our in-vitro and in-vivo experimental studies showed that curcumin inhibited the proliferation of endometrial cancer cells and suppressed the tumor growth in Ishikawa xenograft mouse model...
March 16, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28392482/adult-stem-cells-in-psychiatric-disorders-new-discoveries-in-peripheral-blood
#10
REVIEW
Jolanta Kucharska-Mazur, Marcin Jabłoński, Błażej Misiak, Dorota Frydecka, Janusz Rybakowski, Mariusz Z Ratajczak, Jerzy Samochowiec
The new area of research in psychiatric disorders is concerned with abnormal regeneration processes. The role of brain neurogenesis has been studied for decades. New discoveries, concerned with the pluripotency of VSEL cells and the role of factors involved in stem cell trafficking in peripheral blood create hope that it will be possible to develop a better understanding of the processes of neuroregeneration/neurodegeneration. There is an ongoing research investigating concentrations of: sphingosine -1-phosphate, SDF-1, elements of complement cascade, and stem cells in peripheral blood, including their possible connection to psychiatric disorders...
April 7, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28379992/a-novel-recombinant-antibody-specific-to-full-length-stromal-derived-factor-1-for-potential-application-in-biomarker-studies
#11
Daniel I Bromage, Stasa Taferner, Mahesh Pillai, Derek M Yellon, Sean M Davidson
BACKGROUND: Stromal derived factor-1α (SDF-1α/CXCL12) is a chemokine that is up-regulated in diseases characterised by tissue hypoxia, including myocardial infarction, ischaemic cardiomyopathy and remote ischaemic conditioning (RIC), a technique of cyclical, non-injurious ischaemia applied remote from the heart that protects the heat from lethal ischaemia-reperfusion injury. Accordingly, there is considerable interest in SDF-1α as a potential biomarker of such conditions. However, SDF-1α is rapidly degraded and inactivated by dipeptidyl peptidase 4 and other peptidases, and the kinetics of intact SDF-1α remain unknown...
2017: PloS One
https://www.readbyqxmd.com/read/28374486/a-novel-cxcr4-antagonist-enhances-angiogenesis-via-modifying-the-ischaemic-tissue-environment
#12
Xiaoqing Yan, Xiaozhen Dai, Luqing He, Xiao Ling, Minglong Shao, Chi Zhang, Yuehui Wang, Jian Xiao, Lu Cai, Xiaokun Li, Yi Tan
Endothelial progenitor cells (EPCs) play a capital role in angiogenesis via directly participating in neo-vessel formation and secreting pro-angiogenic factors. Stromal cell-derived factor 1 (SDF-1) and its receptor CXCR4 play a critical role in the retention and quiescence of EPCs within its niche in the bone marrow. Disturbing the interaction between SDF-1 and CXCR4 is an effective strategy for EPC mobilization. We developed a novel CXCR4 antagonist P2G, a mutant protein of SDF-1β with high antagonistic activity against CXCR4 and high potency in enhancing ischaemic angiogenesis and blood perfusion...
April 4, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28367523/stromal-cell-derived-factor-1-cxcr4-and-cxcr7-gene-transcripts-in-pterygia
#13
Shahram Bamdad, Behzad Khademi, Nooshin Chenari, Atta Taseh, Mahboobeh Razmkhah
PURPOSE: Pterygium is a pathologic process with angiogenic and tumor cell like characteristics. Chemokine and chemokine receptors may contribute to the formation and growth of pterygia. The aim of this study was to assess the expression of stromal cell derived factor (SDF)-1, as an angiogenic chemokine, and its receptors, CXCR4 and CXCR7, gene transcripts in pterygia. METHODS: RNA was extracted from tissue samples of 33 patients with primary pterygium and 35 volunteers with conjunctiva as the control group...
March 2017: Journal of Current Ophthalmology
https://www.readbyqxmd.com/read/28351680/human-lung-fibroblast-derived-matrix-facilitates-vascular-morphogenesis-in-3d-environment-and-enhances-skin-wound-healing
#14
Ping Du, Muhammad Suhaeri, Sang Su Ha, Seung Ja Oh, Sang Heon Kim, Kwideok Park
Extracellular matrix (ECM) is crucial to many aspects of vascular morphogenesis and maintenance of vasculature function. Currently the recapitulation of angiogenic ECM microenvironment is still challenging, due mainly to its diverse components and complex organization. Here we investigate the angiogenic potential of human lung fibroblast-derived matrix (hFDM) in creating a three-dimensional (3D) vascular construct. hFDM was obtained via decellularization of in vitro cultured human lung fibroblasts and analyzed via immunofluorescence staining and ELISA, which detect multiple ECM macromolecules and angiogenic growth factors (GFs)...
March 25, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28337256/human-mesenchymal-stem-cell-homing-induced-by-skov3-cells
#15
Dongmei Fan, Xiaojuan Xie, Pengwei Qi, Xianan Yang, Ximeng Jin
Human mesenchymal stem cell (hMSC) homing is the migration of endogenous and exogenous hMSCS to the target organs and the subsequent colonization under the action chemotaxic factors. This is an important process involved in the repair of damaged tissues. However, we know little about the mechanism of hMSC homing. Stromal cell derived factor-1 (SDF-1) is a cytokine secreted by stromal cells. Its only receptor CXCR4 is widely expressed in blood cells, immune cells and cells in the central nervous system. SDF-1/CXCR4 signaling pathway plays an important role in hMSC homing and tissue repair...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28336327/galectin-1-driven-upregulation-of-sdf-1-in-pancreatic-stellate-cells-promotes-pancreatic-cancer-metastasis
#16
Dong Qian, Zipeng Lu, Qingcheng Xu, Pengfei Wu, Lei Tian, Liangtao Zhao, Baobao Cai, Jie Yin, Yang Wu, Kevin F Staveley-O'Carroll, Kuirong Jiang, Yi Miao, Guangfu Li
Galectin-1, mainly expressed in activated pancreatic stellate cells (PSCs), is involved in many important cancer-related processes. However, very little is known how Galectin-1 modulates PSCs and subsequently impacts pancreatic cancer cells (PCCs). Our chemokine antibody array and in vitro studies demonstrates that Galectin-1 induces secretion of stromal cell-derived factor-1(SDF-1) in PSCs by activating NF-κB signaling. The secreted SDF-1 increases migration and invasion of PCCs. Knockdown of Galectin-1 and inhibitor-mediated blockade of SDF-1 as well as its ligand CXCR4 and NF-κB verifies the findings...
March 21, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28322746/truncation-of-cxcl12-by-cd26-reduces-its-cxc-chemokine-receptor-4-and-atypical-chemokine-receptor-3-dependent-activity-on-endothelial-cells-and-lymphocytes
#17
Rik Janssens, Anneleen Mortier, Daiane Boff, Pieter Ruytinx, Mieke Gouwy, Bo Vantilt, Olav Larsen, Viktorija Daugvilaite, Mette M Rosenkilde, Marc Parmentier, Sam Noppen, Sandra Liekens, Jo Van Damme, Sofie Struyf, Mauro M Teixeira, Flávio A Amaral, Paul Proost
The chemokine CXCL12 or stromal cell-derived factor 1/SDF-1 attracts hematopoietic progenitor cells and mature leukocytes through the G protein-coupled CXC chemokine receptor 4 (CXCR4). In addition, it interacts with atypical chemokine receptor 3 (ACKR3 or CXCR7) and glycosaminoglycans. CXCL12 activity is regulated through posttranslational cleavage by CD26/dipeptidyl peptidase 4 that removes two NH2-terminal amino acids. CD26-truncated CXCL12 does not induce calcium signaling or chemotaxis of mononuclear cells...
March 18, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/28318166/-exploratory-study-on-influence-of-biopsy-to-biological-behavior-of-tca8113-transplanted-tumor
#18
Liu Jiyuan, Pan Jian, Hua Chengge, Wu Yunlong, Luo Zhengwen, Tang Xiufa
OBJECTIVE: We established an animal model of nude mice with Tca8113 tumor and cut some tissue for biopsy. We also determined the biological behavior and mechanisms of the tumor. METHODS: The mice were divided into two groups randomly. Mice in both groups were injected with Tca8113 cells into their tongues. The survival condition, growth of primary focus, and metastasis were observed. Hematoxylin and eosin staining and immunohistochemistry were performed on nuclear factor κB (NF-κB), matrix metallopeptidase 9 (MMP-9), vascular endothelial growth factor (VEGF), stromal cell-derived factor 1 (SDF-1), and Ki67 to determine their distributions within the tumor...
December 1, 2016: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/28303409/cardiovascular-inflammation-is-reduced-with-methotrexate-in-diabetes
#19
Adrian Quan, Yi Pan, Krishna K Singh, John Polemidiotis, Hwee Teoh, Howard Leong-Poi, Subodh Verma
Diabetes increases the risk of vascular events and mortality. While earlier type 2 diabetes trials demonstrated that intensive glucose lowering reduces microvascular complications, it is only recently that treatment with some of the newer antihyperglycemic agents has been associated with macrovascular benefits. We report herein that db/db mice concomitantly fed the Western diet and treated with the anti-inflammatory agent methotrexate display a less aggressive inflammatory (lower serum IL-1β, IL-6, SDF-1, and TNFα levels; higher circulating adiponectin, IL-12p70 and IL-10 concentrations; lower aortic VCAM-1 levels) profile than their saline-treated counterpart...
March 16, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28303319/effect-of-sdf-1-cxcr4-signaling-antagonist-amd3100-on-bone-mineralization-in-distraction-osteogenesis
#20
Jia Xu, Yuanfeng Chen, Yang Liu, Jinfang Zhang, Qinglin Kang, Kiwai Ho, Yimin Chai, Gang Li
Distraction osteogenesis (DO) is a widely applied technique in orthopedics surgery, which involves rapid stem cell migration, homing, and differentiation. Interactions between the chemokine receptor Cxcr4 and its ligand, stromal derived factor-1 (SDF-1), regulate hematopoietic stem cell trafficking to the ischemic area and induce their subsequent differentiation. Here, we examined SDF-1 expression and further investigated the role of SDF-1/Cxcr4 signaling antagonist AMD3100 during bone regeneration in rat DO model...
March 16, 2017: Calcified Tissue International
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