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https://www.readbyqxmd.com/read/29787991/synthetic-chalcones-as-potential-tool-for-acute-and-chronic-pain-control
#1
Lilian W Rocha, Daniele R Sonza, Milena Fronza Broering, Roberta Nunes, Fátima de Campos-Buzzi, Rogério Corrêa, Rangel L Silva, Thiago M Cunha, José Roberto Santin, Nara L M Quintão
The purpose of this study was to validate the potential anti-hypersensitive activity of two chalcones, (2E)-1-(4-aminophenyl)-3-(4-nitrophenyl)prop-2-en-1-one (ANCh) and N-{4-[(2E)-3-(4-nitrophenyl)prop-2-enoil]phenyl}acetamide (AcANCh), by different models of acute and persistent pain in mice, besides in silico analysis. Molecules computational investigation for prediction of Lipinki's and Veber's rules to determine solubility, % absorption, drug likeness and toxicity liabilities was performed. Male and female C57BL/6 mice (20-30 g, n = 6) were used...
May 19, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29784508/il-33-mast-cell-axis-is-central-in-ll-37-induced-bladder-inflammation-and-pain-in-a-murine-interstitial-cystitis-model
#2
M Martin Jensen, Wanjian Jia, Austin J Schults, Xiangyang Ye, Glenn D Prestwich, Siam Oottamasathien
Interstitial cystitis (IC), also known as painful bladder syndrome (PBS), is a debilitating chronic condition that afflicts over 3 million women above the age of 18 in the U.S., and most patients fail to respond to current treatment options. Mast cells have previously been implicated as both a diagnostic and prognostic marker in IC/PBS. Patients with IC/PBS have been shown to have elevated levels of IL-33, a cytokine released in response to tissue insult, in their urine. We hypothesize that mast cell-mediated inflammation induced from IL-33 may play an important role in initiating pain and inflammation in IC/PBS...
May 18, 2018: Cytokine
https://www.readbyqxmd.com/read/29780130/esophageal-carcinosarcoma-that-was-diagnosed-as-a-granulocyte-colony-stimulating-factor-and-interleukin-6-producing-tumor-with-a-tumor-fever-a-case-report
#3
Taro Shioga, Shozo Matsushima, Eiji Yamada, Takashi Utiyama, Haruka Noto, Daisuke Suzuki, Takashi Nonaka, Shiro Miyazawa, Tatsuji Komatsu, Yuji Yamamoto, Hitoshi Sekido, Hitoshi Niino
A 51-year-old man visited our hospital with a main complaint of precordial pain, difficulty swallowing, and pyrexia. The patient was diagnosed with esophageal carcinosarcoma, based on the characteristic morphology noted on upper gastrointestinal endoscopy and histology tests, and he underwent surgical treatment. His preoperative blood granulocyte-colony stimulating factor (G-CSF) and interleukin-6 (IL-6) levels were high, and the surgical specimens were positive in both immunohistochemical tests; therefore, he was diagnosed with a G-CSF- and IL-6-producing tumor...
May 18, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29777144/benefits-in-radical-mastectomy-protocol-a-randomized-trial-evaluating-the-use-of-regional-anesthesia
#4
Marcio Matsumoto, Eva M Flores, Pedro P Kimachi, Flavia V Gouveia, Mayra A Kuroki, Alfredo C S D Barros, Marcelo M C Sampaio, Felipe E M Andrade, João Valverde, Eduardo F Abrantes, Claudia M Simões, Rosana L Pagano, Raquel C R Martinez
Surgery is the first-line treatment for early, localized, or operable breast cancer. Regional anesthesia during mastectomy may offer the prevention of postoperative pain. One potential protocol is the combination of serratus anterior plane block (SAM block) with pectoral nerve block I (PECS I), but the results and potential benefits are limited. Our study compared general anesthesia with or without SAM block + PECS I during radical mastectomy with axillary node dissection and breast reconstruction using evaluations of pain, opioid consumption, side effects and serum levels of interleukin (IL)-1beta, IL-6 and IL-10...
May 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29772245/ape1-ref-1-redox-function-contributes-to-inflammatory-pain-sensitization
#5
Amira Zaky, Rabia Bouali-Benazzouz, Alexandre Favereaux, Gianluca Tell, Marc Landry
Inflammatory pain is a complex and multifactorial disorder. Apurinic/apyrimidinic endonuclease 1 (APE1), also called Redox Factor-1 (Ref-1), is constitutively expressed in the central nervous system and regulates various cellular functions including oxidative stress. In the present study, we investigated APE1 modulation and associated pain behavior changes in the complete Freund's adjuvant (CFA) model of inflammatory pain in rats. In addition we tested the anti-inflammatory effects of E3330, a selective inhibitor of APE1-redox activity, in CFA pain condition...
May 14, 2018: Experimental Neurology
https://www.readbyqxmd.com/read/29764574/-clinical-effect-and-mechanism-of-hemoperfusion-in-treatment-of-children-with-severe-abdominal-henoch-sch%C3%A3-nlein-purpura
#6
Ying Zhu, Yang Dong, Da-Liang Xu, Jia-Yun Jiang, Lin Wu, Rui-Juan Ke, Shao-Han Fang, Yin Peng
OBJECTIVE: To study the clinical effect and mechanism of hemoperfusion (HP) in the treatment of children with severe abdominal Henoch-Schönlein purpura (HSP). METHODS: A total of 24 children with severe abdominal HSP were divided into two groups: conventional treatment and HP (n=12 each). Ten healthy children who underwent physical examination were enrolled as the control group. Before and after treatment, chemiluminescence was used to measure the serum levels of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α); thiobarbituric acid colorimetry was used to measure the plasma level of malondialdehyde (MDA); the hydroxylamine method was used to measure the plasma level of superoxide dismutase (SOD); chemical colorimetry was used to measure the plasma level of total anti-oxidant capability (T-AOC)...
May 2018: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/29764470/joint-preserving-palliative-surgery-using-self-locking-screws-of-intramedullary-nail-and-percutaneous-cementoplasty-for-proximal-humeral-metastasis-in-the-advanced-cancer-patients
#7
Jong Woong Park, Yong-Il Kim, Hyun Guy Kang, June Hyuk Kim, Han Soo Kim
BACKGROUND: We introduced a palliative joint-preserving surgery using proximal self-locking screws of intramedullary (IM) nail and percutaneous cementoplasty (PC) in patients with proximal humeral metastases, including the head and neck, and evaluated the outcome of the surgical method. METHODS: Twenty-three patients (mean age = 63.0 ± 11.8 years, M:F = 14:9) had IM nailing with a self-locking screw system and PC for the treatment of humeral head and neck metastases...
May 15, 2018: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29763588/glycyrrhizin-ameliorates-inflammatory-pain-by-inhibiting-microglial-activation-mediated-inflammatory-response-via-blockage-of-the-hmgb1-tlr4-nf-kb-pathway
#8
Xiaojuan Sun, Hongyou Zeng, Qingsong Wang, Qingwen Yu, Jianxiong Wu, You Feng, Peng Deng, Hongxing Zhang
Chronic inflammatory pain is a severe clinical problem that greatly affects patients' quality of life and causes huge economic burden. Microglia-mediated neuroinflammation exerts critical roles in the pathogenic progression of inflammatory pain. Recent evidence corroborates the anti-inflammatory and neuroprotective efficacy of glycyrrhizin; however, its function in inflammatory pain remains poorly elucidated. In the present study, glycyrrhizin suppressed LPS-induced activation of microglial cell BV2 by inhibiting NO production and expression of microglial marker IBA-1...
May 12, 2018: Experimental Cell Research
https://www.readbyqxmd.com/read/29755555/the-ethanolic-extract-of-eysenhardtia-polystachya-ort-sarg-bark-and-its-fractions-delay-the-progression-of-rheumatoid-arthritis-and-show-antinociceptive-activity-in-murine-models
#9
Saudy Saret Pablo-Pérez, Benjamín Parada-Cruz, Olivier Christophe Barbier, María Estela Meléndez-Camargo
Eysenhardtia polystachya is widely used in folk medicine as an anti-rheumatic and analgesic agent, but no systematic study of its effects on several markers associated with rheumatoid arthritis and its ethnomedical use as analgesic agent has been performed. We evaluated the anti-arthritic and antinociceptive properties of an ethanolic extract of E. polystachya (EE) bark and its rich-flavonoids fractions in murine models. The EE was administered orally at doses of 25, 50, 100, and 200 mg/kg/day, and its fractions at 25 mg/kg/day in all animal models...
2018: Iranian Journal of Pharmaceutical Research: IJPR
https://www.readbyqxmd.com/read/29750991/celastrol-attenuates-incision-induced-inflammation-and-pain-associated-with-inhibition-of-the-nf-%C3%AE%C2%BAb-signalling-pathway-via-sarm
#10
Xuhui Chen, Bo Zhang, Jiayan Li, Miaomiao Feng, Yue Zhang, Wenlong Yao, Chuanhan Zhang, Li Wan
AIM: This study aimed to investigate whether celastrol (CEL) could alleviate incision-induced pain and decipher its possible mechanism. MATERIALS AND METHODS: Sprague-Dawley rats were randomly divided into five groups: naïve, vehicle, CEL (5 μg/paw, 10 μg/paw and 20 μg/paw). CEL or vehicle was administered intraplantarly before plantar surgical incision. Histological examinations of skin tissues were performed after HE staining. Additionally, immunohistochemical staining, RT-PCR and western blot were performed to analyse macrophages, proinflammatory cytokines, SARM and NF-κB expression, respectively...
May 8, 2018: Life Sciences
https://www.readbyqxmd.com/read/29745371/microrna-194-inhibits-lipopolysaccharide-induced-inflammatory-response-in-nucleus-pulposus-cells-of-the-intervertebral-disc-by-targeting-tnf-receptor-associated-factor-6-traf6
#11
Lili Kong, Mingxiao Sun, Zhaofu Jiang, Liming Li, Bing Lu
BACKGROUND The dramatic increase of intervertebral disc degeneration (IDD) is considered to be a major cause of discogenic low back pain. The current study focused on the regulatory function of microRNA-194 (miR-194) on lipopolysaccharide (LPS)-induced inflammatory response in nucleus pulposus (NP) cells. MATERIAL AND METHODS LPS was used to treat NP cells to induce inflammatory responses. MiRNA and gene expression were detected by quantitative PCR. Proteins and protein expression levels were detected by Western blot and ELISA kit...
May 10, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29742695/anterior-mediastinal-hodgkin-lymphoma-presenting-as-an-extremely-hypervascular-tumor-on-computed-tomography-a-case-report
#12
Soo Jeong Lee, Ji Young Rho, Gwang Il Kim, Joonsuk Park
RATIONALE: In the thorax, Hodgkin lymphoma (HL) most frequently involves the anterior mediastinal and paratracheal regions and tends to spread to contiguous nodal groups. Enlarged lymph nodes typically have homogeneous soft tissue attenuation similar to that of muscle tissue on computed tomography (CT). PATIENT CONCERNS: A contrast-enhanced CT examination of a 19-year-old man with right-sided chest pain showed an intense, heterogeneously enhancing mass with organization of serpentine and dilated blood vessels in the right anterior mediastinum that had invaded the upper lobe of the right lung...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29739272/notochordal-cell-matrix-as-a-therapeutic-agent-for-intervertebral-disc-regeneration
#13
Stefan de Vries, Marina van Doeselaar, Björn Meij, Marianna A Tryfonidou, Keita Ito
Notochordal cells (NCs) reside in the core of the healthy disc and produce soluble factors that can stimulate nucleus pulposus cells (NPCs). These NC-derived factors may be applied in intervertebral disc regeneration for treatment of low back pain. However, identification of the active soluble factors is challenging. Therefore a novel approach to directly use porcine NC-rich NP matrix (NCM) is introduced. We explored porcine NCM's anabolic effects on bovine NPCs harvested from caudal discs of adolescent and adult (2-2...
May 9, 2018: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/29737303/curative-effect-of-oral-ulcer-powder-on-the-treatment-of-recurrent-aphthous-ulcer
#14
Shenshan Zhu, Qiaoyun Shi, Jian Lu
Recurrent aphthous ulcer (RAU) is a common and frequently occurring disease in the Department of Stomatology. The clinical manifestations are localized ulcer of oral mucosa, and the ulcer mask is self limiting and easy to recur. In this paper, by adopting the randomized study method, the author study the effect of oral ulcer powder combined with traditional Chinese drugs on patients with recurrent aphthous ulcer, and analyze its effect on inflammatory factor. Kangfuxin liquid combined with oral ulcer powder helps reduce recurrent aphthous ulcer patients the levels of inflammatory factors, improve the symptoms of pain...
May 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29736690/osthole-ameliorates-neurogenic-and-inflammatory-hyperalgesia-by-modulation-of-inos-cox-2-and-inflammatory-cytokines-in-mice
#15
Gurjit Singh, Rajbir Bhatti, Rahul Mannan, Drishtant Singh, Anup Kesavan, Palwinder Singh
BACKGROUND: Osthole is a bioactive component reported in medicinal plants such as Angelica pubescens and Cnidium monnieri, known for analgesic activity. However, the toxicity, median effective dose (ED50 ), and dual modulation of nitric oxide and cyclooxygenase pathways along with inflammatory cytokines of osthole are yet to be determined. METHODS: The animals (mice) were assessed for general behaviour and mortality in varying doses (50, 300, and 2000 mg kg-1 ) of osthole for acute toxicity over 14 days...
May 7, 2018: Inflammopharmacology
https://www.readbyqxmd.com/read/29735869/effects-of-a-cyclic-nsaid-regimen-on-levels-of-gingival-crevicular-fluid-prostaglandin-e-2-and-interleukin-1%C3%AE-a-6-month-randomized-controlled-clinical-trial
#16
B F Oduncuoglu, N A Kayar, S Haliloglu, B Serpek, T Ataoglu, N O Alptekin
Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used for inflammation control and pain relief. However, while the adjunct use of NSAIDs is avoided for periodontal therapy because of related side effects, cyclic administration of NSAIDs may reduce or eliminate these effects. We evaluated the effect of a cyclic diclofenac potassium (DP) regimen on clinical parameters and levels of prostaglandin E2 (PGE2 ) and interleukin-1β (IL-1β) in the gingival crevicular fluid (GCF) of individuals with periodontitis...
May 2018: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/29735470/curative-effect-of-oral-ulcer-powder-on-the-treatment-of-recurrent-aphthous-ulcer
#17
Shenshan Zhu, Qiaoyun Shi, Jian Lu
Recurrent aphthous ulcer (RAU) is a common and frequently occurring disease in the Department of Stomatology. The clinical manifestations are localized ulcer of oral mucosa, and the ulcer mask is self limiting and easy to recur. In this paper, by adopting the randomized study method, the author study the effect of oral ulcer powder combined with traditional Chinese drugs on patients with recurrent aphthous ulcer, and analyze its effect on inflammatory factor. Kangfuxin liquid combined with oral ulcer powder helps reduce recurrent aphthous ulcer patients the levels of inflammatory factors, improve the symptoms of pain...
May 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29729431/effects-of-cannabinoid-type-2-receptor-agonist-am1241-on-morphine-induced-antinociception-acute-and-chronic-tolerance-and-dependence-in-mice
#18
Mingyue Zhang, Linlin Dong, Huichao Zou, Junnan Li, Quanyi Li, Guonian Wang, Hulun Li
Morphine is a potent opioid analgesic used to alleviate moderate or severe pain but the development of drug tolerance and dependence limits its use in pain management. Previous studies showed that cannabinoid type 2 (CB2 ) receptor ligands may modulate opioid effects. However, there is no report of the effect of CB2 receptor agonist on acute morphine tolerance and physical dependence. We therefore investigated the effect of a CB2 receptor agonist (AM1241) on morphine-induced morphine tolerance and physical dependence in mice...
May 2, 2018: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29727735/therapeutic-potential-of-wild-medicinal-plant-zizyphus-mauritiana-against-silica-induced-toxicity-in-wistar-albino-rats
#19
Rudra Prasad Dutta, M B Patil
ETHNOPHARMACOLOGICAL RELEVANCE: Zizyphus mauritiana (L.) of the family Rhamnaceae is a traditional herbal medicinal plant and commonly called as 'ber' (Indian jujube). It is traditionally used as food source and treats various diseases like malaria, asthma, pain killer, diarrhoea, typhoid, diabetes, and skin diseases, etc. AIM OF THE STUDY: This study aimed to evaluate the ability of extracts of barks of root and stem of Zizyphus mauritiana (ZM) to cure silica induced toxicity in Wistar albino rats...
May 1, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29723636/mechanical-loading-of-intervertebral-disc-modulates-microglia-proliferation-activation-and-chemotaxis
#20
Stefania Elena Navone, Marianna Peroglio, Laura Guarnaccia, Matteo Beretta, Sibylle Grad, Moira Paroni, Chiara Cordiglieri, Marco Locatelli, Mauro Pluderi, Paolo Rampini, Rolando Campanella, Mauro Alini, Giovanni Marfia
OBJECTIVE: The aim of the study is to assess the effects of the neuroinflammatory microenvironment of a mechanically-induced degenerating IVD on neuroinflammatory like cells such as microglia, in order to comprehend the role of microglial cells in degenerative disc disease. METHODS: Bovine caudal IVDs were kept in culture in an ex vivo bioreactor under high frequency loading and limited nutrition or in free swelling conditions as control samples. Conditioned media (CM) were collected, analysed for cytokine and neurotrophin content and applied to microglial cells for neuroinflammatory activation assessment...
April 30, 2018: Osteoarthritis and Cartilage
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