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botulinic toxin dystonia

Kazimierz Tomczykiewicz
Cervical dystonia is the most common form of dystonia in adult age. It is characterized by involuntary muscle contractions that cause abnormal movements and positioning of the head and neck. Symptoms of it are often associated with pain. This distinguishes this form from other dystonia. The drug of choice is botulinum toxin. It effectively reduces both pain and abnormal excessive muscle activity. In some cases, particularly where there is not obtained the full recovery after treatment botulinum toxin we used drugs for systemic effect...
August 2016: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
Kazimierz Cervical Dystonia Treatment With Botulin Toxin
Cervical dystonia is the most common form of dystonia in adult age. It is characterized by involuntary muscle contractions that cause abnormal movements and positioning of the head and neck. Symptoms of it are often associated with pain. This distinguishes this form from other dystonia. The drug of choice is botulinum toxin. It effectively reduces both pain and abnormal excessive muscle activity. In some cases, particularly where there is not obtained the full recovery after treatment botulinum toxin we used drugs for systemic effect...
July 2016: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
Yu Ma, Ming Ge, Fangang Meng, Kai Zhang, Jianguo Zhang
Fahr's disease (FD) is a rare movement disorder characterized by bilateral intracranial calcifications that is refractory to most treatments. We present the case of a 26-year-old male with FD who was unable to walk independently and could not eat solid food because of poor swallowing capability and severe cervical dystonia. Injections of botulin toxin into the neck muscles, as well as biperiden, tiapride, amantadine, L-dopa and clonazepam were ineffective. Deep brain stimulation (DBS) was performed with two permanent electrodes containing four contact sites implanted bilaterally into the subthalamic nucleus (STN)...
August 2013: International Journal of Neuroscience
Kyösti Sotaniemi
Botulin is established as first-line treatment in cervical dystonia, blepharospasm, hemifacial spasm and stroke-related spasticity of the distal parts of the upper limb. In addition, many other motor disorders and muscular hyperactivity states and neurologic symptoms and manifestations, in which temporary muscle paralysis, analgesic properties and effects on the functioning of the autonomic nervous system brought about by botulin can be utilized, have become indications for use. With proper dosage, botulin has proven to be safe even in prolonged use, the effect usually lasting for years...
2011: Duodecim; Lääketieteellinen Aikakauskirja
Noemi Grigoletto De Biase, Paulo Augusto de Lima Pontes, Vanier Junior Santos, Vanessa Pedrosa Vieira, Priscila Zambonato, Reinaldo Kazuo Yazaki
UNLABELLED: Respiratory dystonia is a rare and difficult to diagnose disorder, that causes breathing restriction of various degrees. The objective of the study is to report the case of a patient with respiratory dystonia involving the larynx and the pharynx and its evolution concerning spasms intensity and control. CASE REPORT: A 24 year-old-man has been followed for 5 years. The diagnosis was made by means of nasofibroscopy and electromyography. Treatment was carried out with laryngeal and pharyngeal Botulin toxin injections, as it became necessary for symptoms control...
March 2007: Brazilian Journal of Otorhinolaryngology
Aude Morelet, Laurence Gagneux-Lemoussu, Pascal Brochot, Stanley Ackah-Miezan, Jean-François Colmet-Daage, François Gaillard, François Boyer, Jean-Paul Eschard, Jean-Claude Etienne
Tonic dystonia is an underrecognized complication of reflex sympathetic dystrophy syndrome (RSDS) characterized by an increase in muscle tone at the site of injury. Case-reports.- We describe five cases of tonic dystonia complicating RSDS of the lower extremity. There were four women and one man, with a mean age of 52 years. In addition to the typical features of RSDS, the patients had fixed equinovarus of the foot with hyperextension or hyperflexion of the great toe. In two patients, examination after spinal anesthesia showed that the deformity was reducible...
May 2005: Joint, Bone, Spine: Revue du Rhumatisme
Teofan M Domzał, Kazimierz Tomczykiewicz
Laryngeal dystonia is a focal dystonia occurring more often than it is diagnosed. Adductor type dystonia was described in 5 patients. In 3 cases it manifested itself as blepharospasm, which later developed into Meige's syndrome. The patients were treated with botulinum toxin A injections under EMG control administering 10 i.m. into laryngeal muscles on both sides with good and very good results. There were no serious side effects.
January 2002: Neurologia i Neurochirurgia Polska
F Aguilar-Rebolledo, J Hernández-Sánchez, D Rayo-Mares, F Soriano-Fonseca, L García-Muñoz, J Ruiz-Ponce, E Garrido-Ramírez
UNLABELLED: Treatment of spasticity and dystonía in PCI with Botulinum toxin A. BACKGROUND: Botulinum-A (NxTxBoA) toxin produce neuromuscular blockade, it has been effective with therapeutic purposes in strabismus, focal dystonias and spasticity. OBJECTIVE: Evaluate the therapeutically effects off NxTxBoA in cerebral palsy (CP) spastic and/or dystonic in children. Prospective study. MATERIAL AND METHODS: 12 CP patients (8 spastic and 4 spastic/dystonic) were treated with NxTxBoA in affected muscles at least for 2 doses by up 12 months...
September 2001: Gaceta Médica de México
A Kohler, F Ochsner
Botulinum toxin is more and more frequently used as a therapeutic agent. The toxin blocks selectively and reversibly the neuromuscular junction, causing a muscle relaxation. Indications are mainly muscular hypercontraction, such as dystonia, blepharospasm, focal spasticity, strabismus or tics. The range of action extend to focal hyperhydrosis, palmar, axillary or plantar. It seems now that some painful syndrome such as migraine or tension headache may benefit from toxin injections. Esthetic indications constitute an extension to the pure medical indications...
June 2001: Revue Médicale de la Suisse Romande
J Christiansen, E Bruun, B Skjoldbye, K Hagen
PURPOSE: This study was undertaken to analyze whether intra-anal ultrasound examination, anorectal physiologic evaluation, and histopathologic examination in patients with chronic idiopathic anal pain presented any common features and whether the results of different treatment modalities correlated with these findings. METHODS: Eighteen patients who met the criteria for chronic idiopathic anal pain were studied. All had an intra-anal ultrasound examination and a complete anorectal physiologic evaluation...
May 2001: Diseases of the Colon and Rectum
C Tranchant
Blepharospasm, spasmodic torticoli, and writer's cramp are the most frequently observed forms of focal dystonia. Primary dystonia is often a hereditary condition with a dominant autosomal mode of transmission and variable penetrance. Secondary conditions are generally the expression of a lesion to the basal ganglia due to an iatrogenic cause or exceptionally the inaugural sign of a metabolic disease. The basal ganglia play an important role in the pathophysiology of this reciprocal innervation disorder but progress in genetics may help better understand the different molecular mechanisms involved...
December 2000: Revue Neurologique
T M Domzał
Only in the second half of the 20th century a breakthrough occurred in the traditional neurological therapeutic methods based up to that time mainly on bromine with valerian extract and vitamins B. Later on in that century several great discoveries were made which improved greatly the effectiveness of the neurological therapy: psychopharmacology which began with the introduction of chlorpromazine and reserpine, the use of corticosteroids for which the Nobel award was given, levodopa introduction for Parkinson's disease, non-steroid antiinflammatory agents and the demonstration of their action mechanism /also Nobel award/, immunotherapy, botulin toxin for the treatment of dystonias and thrombolytic drugs possibly the drugs of the future...
1999: Neurologia i Neurochirurgia Polska
O Keren, F Shinberg, A Catz, N Giladi
Therapeutic injection of botulin toxin is well-recognized for reducing tonus in local dystonia. However, its efficacy in reducing spasticity in spinal cord injuries is still unproven. 4 men and 1 woman (mean age 39 years, range 20-56) with spinal cord injury and debilitating spasticity, and no response to standard treatment for spasticity received injections of botulin, 200-300 U, into 4-8 points in their legs to block muscle-nerve synapses. In all 5 tonus was reduced in the area of the block, while in some it was also reduced in more distal muscles...
February 1, 2000: Harefuah
S L Timerbaeva, I A Ivanova-Smolenskaia, E D Markova, V V Poleshchuk, M V Karapetian, O Iu Rebrova
No abstract text is available yet for this article.
2000: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
M Zielińska, K Selmaj
We present a case of 47-year old patient with a rare form of focal dystonia restricted to laryngeal adductors with blepharospasm. Apart from typical symptoms of blepharospasm, the patient had severe problems with articulation in the form of harsh voice, frequently interrupted speech and the sound coming out with a great effort. We applied a transcutaneous botulin toxin therapy to this patient. The toxin was given into thyroarytenoid muscle in transcutaneous injections under control of EMG. Successful clinical effect was achieved with the dose of 80 U of the botulin toxin (Dysport) and lasted 6 months...
September 1998: Neurologia i Neurochirurgia Polska
H Fdhil, M O Krebs, F Bayle, J M Vanelle, J P Olie
Tardive dystonia is one of the most serious adverse events of typical neuroleptic treatments. They differ from tardive dyskinesia by their clinical and evolutive features. The occurrence of tardive dystonia due to new antipsychotics remained unknown. For the first time in the literature, we report a case of typical tardive dystonia occurring in a young male schizophrenic patient treated for 8 months with risperidone. No remission was observed despite several therapeutics including botulinic toxin.
November 1998: L'Encéphale
A Bogucki
All forms of limb dystonia can be treated with botulin toxin injection. The selection of dystonic muscles and performing the injections in writer's cramp are discussed in detail. Treatment strategy and outcome in other forms of limb dystonia are presented.
1998: Neurologia i Neurochirurgia Polska
F Gracia, L C Castillo
Dystonia is a neurologic disease characterized by involuntary repetitive muscular contractions which frequently causes torsion, spasmodic movements or abnormal postures. Pharmacologic and surgical treatment had been unsatisfactory in the majority of the cases. Intramuscular botulinic toxin application in focal dystonia disorders, achieve relief in approximately 90% of the cases by quimiodenervation. We included 35 patients with focal dystonia treated between November 1994 through June 1996: 14 facial hemispasm, nine blepharospasm, five cervical dystonia, two writer's cramps, one oromandibular dystonia and four patients with mixed focal dystonia...
September 1996: Revista Médica de Panamá
N J Diederich, C L Comella, C G Goetz
No abstract text is available yet for this article.
February 1, 1997: La Presse Médicale
B Van Durme, I Loeb, J Van Reck
The authors describe the Meige's Syndrome also known as blepharospasm or mandibulo-oral dystonia. This Syndrome rather known by Neurologists and Ophthalmologists than by Stomatologists actually benefits by a specific treatment based on botulin toxins.
March 1996: Acta Stomatologica Belgica
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