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https://www.readbyqxmd.com/read/29341460/intellectual-disability-and-epilepsy-due-to-the-k-l-mediated-xq28-duplication-further-evidence-of-a-distinct-dosage-dependent-phenotype
#1
David Isum Ward, Bethany A Buckley, Eyby Leon, Jullianne Diaz, Margaret Faust Galegos, Sean Hofherr, Amy Feldman Lewanda
Copy number variants of the X-chromosome are a common cause of X-linked intellectual disability in males. Duplication of the Xq28 band has been known for over a decade to be the cause of the Lubs X-linked Mental Retardation Syndrome (OMIM 300620) in males and this duplication has been narrowed to a critical region containing only the genes MECP2 and IRAK1. In 2009, four families with a distal duplication of Xq28 not including MECP2 and mediated by low-copy repeats (LCRs) designated "K" and "L" were reported with intellectual disability and epilepsy...
January 17, 2018: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/29341283/mogamulizumab-induced-phosensitivity-in-patients-with-mycosis-fungoides-and-other-t-cell-neoplasms
#2
Y Masuda, K Tatsuno, S Kitano, H Miyazawa, J Ishibe, M Aoshima, T Shimauchi, T Fujiyama, T Ito, Y Tokura
BACKGROUND: Mogamulizumab (Mog) is a defucosylated, therapeutic monoclonal antibody, targeting CCR4, and was first approved in Japan for the treatment of adult T cell leukaemia/lymphoma (ATLL), followed by cutaneous T cell lymphoma and peripheral T cell lymphoma. OBJECTIVE: To retrospectively investigate development of photosensitivity in patients with mycosis fungoides and other T cell neoplasms after treatment with Mog. METHODS: We treated 7 cutaneous lymphoma patients with Mog...
January 16, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29340992/prospective-comparative-study-of-laparoscopic-narrow-band-imaging-nbi-versus-standard-imaging-in-gynecologic-oncology
#3
Alessia Aloisi, Yukio Sonoda, Ginger J Gardner, Kay J Park, Sarah L Elliott, Qin C Zhou, Alexia Iasonos, Nadeem R Abu-Rustum
BACKGROUND: Narrow band imaging (NBI) is an optic filtration enhancement for endoscopy that uses two wavelengths of light (415 and 540 nm) to highlight superficial microvascular patterns. It has been successfully utilized to improve identification of lesions with abnormal vasculature, which is associated with endometriosis and endometrial cancer. Case studies suggest it may also facilitate surgical staging of gynecologic cancer, which is critical in determining appropriate adjuvant therapies...
January 16, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29340397/ligand-modification-of-uio-66-with-an-unusual-visible-light-photocatalytic-behavior-for-rhb-degradation
#4
Xixi Mu, Jifei Jiang, Fufang Chao, Yongbing Lou, Jinxi Chen
A series of isostructural UiO-66-X (X = H, NH2, Br, (OH)2, (SH)2) catalysts have been successfully synthesized by modifying different functional groups on the ligand. The effects of the ligand modification of UiO-66 were investigated for their photocatalytic activity of Rhodamine B degradation under visible light. Surprisingly, UiO-66-NH2 and UiO-66-(OH)2 which have narrow bandgaps and excellent visible light absorption do not show outstanding photocatalytic performances compared to UiO-66 and UiO-66-Br. Electrochemical test results indicated that the conduction band potential of UiO-66-X and the separation efficiency of electrons were quite important in these photocatalytic reactions, other than the electronic effect as reported...
January 17, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29339952/narrow-band-imaging-for-diagnosing-gastroesophageal-reflux-disease
#5
D Nageshwar Reddy
No abstract text is available yet for this article.
December 2017: Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29339948/update-on-functional-heartburn
#6
Takahisa Yamasaki, Jessica O'Neil, Ronnie Fass
The definition of functional heartburn has been refined over the years. It is currently described, based upon Rome IV criteria, as typical heartburn symptoms in the presence of normal upper endoscopy findings (including normal biopsies), normal esophageal pH testing, and a negative association between symptoms and reflux events. Functional heartburn is very common, affecting women more than men, and with reflux hypersensitivity makes up the majority of heartburn patients who fail twice-daily proton pump inhibitor therapy...
December 2017: Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29339786/integrated-mirna-mrna-spatial-signature-for-oral-squamous-cell-carcinoma-a-prospective-profiling-study-of-narrow-band-imaging-guided-resection
#7
Camile S Farah, Simon A Fox, Andrew J Dalley
Oral squamous cell carcinoma (OSCC) is a common malignancy for which there is poor prognosis and limited therapeutic options. The objective was to identify mRNA targets of dysregulated miRNAs in OSCC using integrated analysis and understand molecular abnormality in surgical margins. We used biopsies along the spatial axis from normal tissue defined by narrow band imaging (NBI) through conventional white light (WL) margins to tumour from 18 patients undergoing surgical resection for OSCC. Overall 119 miRNA and 4794 mRNA were differentially expressed along the adjacent normal tissue to tumour axis...
January 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29338183/plasma-induced-oxygen-vacancies-in-urchin-like-anatase-titania-coated-by-carbon-for-excellent-sodium-ion-battery-anodes
#8
Qingmeng Gan, Hanna He, Kuangmin Zhao, Zhen He, Suqin Liu, Shuping Yang
The incorporation of oxygen vacancies in anatase TiO2 has been studied as a promising way to accelerate the transport of electrons and Na+ ions, which is important for achieving excellent electrochemical properties for anatase TiO2. However, wittingly introducing oxygen vacancies in anatase TiO2 for sodium-ion anode by a facile and effective method is still a challenge. In this work, we report an innovative method to introduce oxygen vacancies into the urchin-like N-doped carbon coated anatase TiO2 (NC-DTO) by a facile plasma treatment...
January 17, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29336196/effect-of-chromoendoscopy-filters-on-visualization-of-ktp-laser-associated-tissue-changes-a-cadaveric-animal-model
#9
Christopher M Johnson, Mariah B Pate, Gregory N Postma
Standard KTP laser (potassium titanyl phosphate) wavelength-specific protective eyewear often impairs visualization of tissue changes during laser treatment. This sometimes necessitates eyewear removal to evaluate tissue effects, which wastes time and poses safety concerns. The objective was to determine if "virtual" or "electronic" chromoendoscopy filters, as found on some endoscopy platforms, could alleviate the restricted visualization inherent to protective eyewear. A KTP laser was applied to porcine laryngeal tissue and recorded via video laryngoscopy with 1 optical (Olympus Narrow Band Imaging) and 8 digital (Pentax Medical I-scan) chromoendoscopy filters...
January 1, 2018: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29335710/continuous-flow-trapping-and-localized-enrichment-of-micro-and-nano-particles-using-induced-charge-electrokinetics
#10
Cunlu Zhao, Chun Yang
In this work, we report an effective microfluidic technique for continuous-flow trapping and localized enrichment of micro- and nano-particles by using induced-charge electrokinetic (ICEK) phenomena. The proposed technique utilizes a simple microfluidic device that consists of a straight microchannel and a conducting strip attached to the bottom wall of the microchannel. Upon application of the electric field along the microchannel, the conducting strip becomes polarized to introduce two types of ICEK phenomena, the ICEK flow vortex and particle dielectrophoresis, and they are identified by a theoretical model formulated in this study to be jointly responsible for the trapping of particles over the edge of the conducting strip...
January 16, 2018: Soft Matter
https://www.readbyqxmd.com/read/29331778/synthesis-of-a-novel-narrow-band-gap-iron-ii-iii-oxide-titania-silver-silicate-nanocomposite-as-a-highly-efficient-and-stable-visible-light-driven-photocatalyst
#11
Huiping Chen, Nan Chen, Chuanping Feng, Yu Gao
Ag6Si2O7, a visible light-driven photocatalyst, has attracted considerable attention owing to its enormous environmental remediation potential. In this work, a magnetic iron(II,III) oxide/titania/silver silicate (Fe3O4/TiO2/Ag6Si2O7) nanocomposite was synthesized by anchoring TiO2 and Ag6Si2O7 on the surface of Fe3O4 nanoparticles. The morphology, crystal structure, as well as the spectroscopic, magnetic, and photocurrent properties of the as-prepared Fe3O4/TiO2/Ag6Si2O7 nanocomposite were studied. Methylene blue (MB) was used for evaluating the photocatalytic performance under simulated visible light...
January 6, 2018: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29331222/on-tubing-fluorescence-measurements-of-the-band-broadening-of-contemporary-injectors-in-ultra-high-performance-liquid-chromatography
#12
Ken Broeckhoven, Kim Vanderlinden, Davy Guillarme, Gert Desmet
We report on a detailed study of the injection contribution to band broadening in contemporary UHPLC-instruments, using either flow-through needle or fixed loop injection (full loop). Using on-tubing fluorescence measurements at the outlet of the injector valve, very localized and undisturbed measurements were obtained. Varying both the flow rate and the injected volume allowed to split the injection variance (σV2,inj) in a volumetric component (related to the amount injected) and a hydrodynamic component (related to the flow rate)...
December 15, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29330859/differential-effects-of-phototherapy-adalimumab-and-betamethasone-calcipotriol-on-effector-and-regulatory-t-cells-in-psoriasis
#13
I S Kotb, B J Lewis, R N Barker, A D Ormerod
BACKGROUND: Psoriasis is a chronic T cell-mediated skin disease with marked social and economic burdens. Current treatments are unsatisfactory, with unpredictable remission times and incompletely understood modes of action. Recent advances in our understanding of the pathogenesis of psoriasis identify the imbalance between CD4+ T effector cells, particularly the T helper (Th) 17 subset, and regulatory T cells (Treg) as key to the development of psoriatic lesions, and therefore a novel therapeutic target...
January 12, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29328326/quadrupole-mode-plasmon-resonance-enabled-subwavelength-metal-dielectric-grating-optical-reflection-filters
#14
Ziyi Wang, Rongjun Zhang, Junpeng Guo
A metal-dielectric subwavelength grating structure was investigated for making single-peak narrow linewidth optical reflection filters in the near-infrared region. The subwavelength grating filter structure consists of a one-dimensional periodic array of metal (gold) and dielectric (Al2O3) elements on a dielectric substrate. Optimized reflection filters have a single reflection peak with ~10 nm linewidth in the infrared region over a wide spectral band. Finite-difference time-domain (FDTD) simulations and multipole analysis show that the narrow linewidth reflection is due to the coupling of the Rayleigh anomaly wave to the quadrupole plasmon resonance mode of the subwavelength metal-dielectric grating...
January 8, 2018: Optics Express
https://www.readbyqxmd.com/read/29325392/horizontal-localization-in-simulated-unilateral-hearing-loss
#15
Anvarsamarein Parisa, Nazeri Ahmad Reza, Sameni Seyyed Jalal, Kamali Mohammad, Zarrin Koob Homa
BACKGROUND AND OBJECTIVES: The ability to localize a sound source is one of the binaural hearing benefits in a horizontal plane based on interaural time difference and interaural intensity difference. Unilateral or bilateral asymmetric hearing loss will affect binaural hearing and lead to sound locating errors. In this cross sectional analytical descriptive study, the localization error was investigated when participants turned their heads to the sound source with closed eyes and after simulating unilateral hearing loss by placing earplugs inside the right ear canal...
December 2017: Journal of Audiology & Otology
https://www.readbyqxmd.com/read/29323484/quaternary-layered-semiconductor-ba2cr4gese10-synthesis-crystal-structure-and-thermoelectric-properties
#16
Hong Chen, Yu-Kun Chen, Hua Lin, Jin-Ni Shen, Li-Ming Wu, Xin-Tao Wu
A quaternary narrow-band-gap semiconductor, Ba2Cr4GeSe10, has been discovered by solid-state reaction. It features a new structure type and crystallizes in the triclinic space group P1̅ (No. 2). The featured 2D anionic layers are constructed by condensed CrSe6 octahedra that are stacking along the c axis, with dispersed GeSe4 tetrahedra and located Ba2+ cations forming these layers. The energy-band structure shows a clear separation between the region of electronic conduction and the zone of electronic insulation...
January 11, 2018: Inorganic Chemistry
https://www.readbyqxmd.com/read/29323235/the-value-of-narrow-band-imaging-in-diagnosis-of-head-and-neck-cancer-a-meta-analysis
#17
Hui Zhou, Jing Zhang, Linghong Guo, Ji Nie, Chenjing Zhu, Xuelei Ma
Head and neck cancer is difficult to diagnose early. We aimed to estimate the diagnosis value of narrow band imaging(NBI) in head and neck cancers. We identified relevant studies through a search of PubMed, Embase and the Cochrane Library. We used a random effect model. Subgroup analysis and meta-regression analysis were performed to estimate the factors which may influence the sensitivity and specificity of the NBI. We included 25 studies with total 6187 lesions. The pooled sensitivity, specificity, positive likelihood rate, negative likelihood rate and diagnostic odds ratios of NBI were 88...
January 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29322573/narrow-band-imaging-versus-laryngovideostroboscopy-in-precancerous-and-malignant-vocal-fold-lesions
#18
Anna Rzepakowska, Ewelina Sielska-Badurek, Raul Cruz, Maria Sobol, Ewa Osuch-Wójcikiewicz, Kazimierz Niemczyk
BACKGROUND: This is a comparative analysis of the diagnostic accuracy of narrow band imaging (NBI) and laryngovideostroboscopy (LVS) in the assessment of premalignant and malignant vocal fold lesions. METHODS: A prospective analysis was performed on 105 consecutive patients with vocal fold lesions. The NBI and LVS were obtained before the microsurgery. RESULTS: The NBI and LVS showed no significant differences in identifying premalignant and malignant pathologies...
January 10, 2018: Head & Neck
https://www.readbyqxmd.com/read/29320445/chlorophyll-inspired-red-region-fluorophores-building-block-synthesis-and-studies-in-aqueous-media
#19
Rui Liu, Mengran Liu, Don Hood, Chih-Yuan Chen, Christopher J MacNevin, Dewey Holten, Jonathan S Lindsey
Fluorophores that absorb and emit in the red spectral region (600-700 nm) are of great interest in photochemistry and photomedicine. Eight new target chlorins (and 19 new chlorins altogether)-analogues of chlorophyll-of different polarities have been designed and synthesized for various applications; seven of the chlorins are equipped with a bioconjugatable tether. Hydrophobic or amphiphilic chlorins in a non-polar organic solvent (toluene), polar organic solvent (DMF), and aqueous or aqueous micellar media show a sharp emission band in the red region and modest fluorescence quantum yield (Φf = 0...
January 10, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29319710/nanoassembly-of-quantum-emitters-in-hexagonal-boron-nitride-and-gold-nanospheres
#20
Minh Nguyen, Sejeong Kim, Toan Trong Tran, Zai-Quan Xu, Mehran Kianinia, Milos Toth, Igor Aharonovich
The assembly of quantum nanophotonic systems with plasmonic resonators is important for fundamental studies of single photon sources as well as for on-chip information processing. In this work, we demonstrate the controllable nanoassembly of gold nanospheres with ultra-bright narrow-band quantum emitters in 2D layered hexagonal boron nitride (hBN). We utilize an atomic force microscope (AFM) tip to precisely position gold nanospheres to close proximity to the quantum emitters and observe the resulting emission enhancement and fluorescence lifetime reduction...
January 10, 2018: Nanoscale
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