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https://www.readbyqxmd.com/read/29230190/daith-piercing-in-a-case-of-chronic-migraine-a-possible-vagal-modulation
#1
Angelo Cascio Rizzo, Matteo Paolucci, Riccardo Altavilla, Nicoletta Brunelli, Federica Assenza, Claudia Altamura, Fabrizio Vernieri
Daith piercing is an ear piercing located at the crus of the helix, bilaterally. It is getting great consent on social media as alternative treatment in chronic migraine. No data about its efficacy and action are available in scientific literature so far. We present the case of a 54-year-old male patient suffering from refractory chronic migraine with medication-overuse, who substantially improved after bilateral ear daith piercing. His migraine was refractory to symptomatic as well as prophylactic therapies...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29229209/randomized-double-blind-placebo-controlled-dose-escalation-study-investigation-of-the-safety-pharmacokinetics-and-antihyperalgesic-activity-of-l-4-chlorokynurenine-in-healthy-volunteers
#2
Mark Wallace, Alexander White, Kathy A Grako, Randal Lane, Allen Jo Cato, H Ralph Snodgrass
BACKGROUND AND AIMS: Neuropathic pain is a significant medical problem needing more effective treatments with fewer side effects. Overactive glutamatergic transmission via N-methyl-d-aspartate receptors (NMDARs) are known to play a role in central sensitization and neuropathic pain. Although ketamine, a NMDAR channel-blocking antagonist, is often used for neuropathic pain, its side-effect profile and abusive potential has prompted the search for a safer effective oral analgesic. A novel oral prodrug, AV-101 (l-4 chlorokynurenine), which, in the brain, is converted into one of the most potent and selective GlyB site antagonists of the NMDAR, has been demonstrated to be active in animal models of neuropathic pain...
October 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29225332/effects-of-acute-systemic-inflammation-on-the-interplay-between-sad-mood-and-affective-cognition
#3
REVIEW
Sven Benson, Alexandra Brinkhoff, Larissa Lueg, Till Roderigo, Andreas Kribben, Benjamin Wilde, Oliver Witzke, Harald Engler, Manfred Schedlowski, Sigrid Elsenbruch
Experimental endotoxemia is a translational model to study inflammatory mechanisms involved in the pathophysiology of mood disorders including depression. Disturbed affective cognition constitutes a core aspect in depression, but has never been studied in the context of inflammation. We combined experimental endotoxemia with an established experimental mood induction procedure to assess the interaction between acute inflammation and sad mood and their effects on affective cognition. In this randomized cross-over study, N = 15 healthy males received endotoxin (0...
December 11, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/29225152/a-randomized-controlled-trial-of-intra-aortic-adenosine-infusion-before-release-of-the-aortic-cross-clamp-during-coronary-artery-bypass-surgery
#4
Amany Ammar, Khaled Mahmoud, Ahmed Elkersh, Zeinab Kasemy
OBJECTIVES: To assess the feasibility, safety, and potential useful effect of adenosine as a postconditioning agent in patients undergoing coronary artery bypass grafting surgeries. DESIGN: Prospective randomized controlled study. SETTING: University hospital. PARTICIPANTS: The study comprised 60 patients scheduled for coronary artery bypass grafting surgery. INTERVENTIONS: Adenosine (postconditioning group) or placebo (control group)...
December 7, 2017: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29223599/pharmacological-intervention-and-abstinence-in-smokers-undergoing-cessation-treatment-a-psychophysiological-study
#5
Yong Cui, Jeffrey M Engelmann, Jonathan Xian, Jennifer A Minnix, Cho Y Lam, Maher Karam-Hage, Paul M Cinciripini, Jason D Robinson
As a composite concept, negative affect comprises various aversive emotional experiences, such as irritability and nervousness. It is a critical motivational factor that helps maintain smoking behavior, and contributes significantly to smoking cessation failure as a core withdrawal symptom. Prior research has indicated an important role of nicotinic mechanisms in negative affect processing. The most effective smoking cessation medication, varenicline, targets nicotinic acetylcholine receptors (nAChRs) as a partial agonist, while another first-line cessation medication, bupropion, has shown antagonistic effects on nAChRs...
December 6, 2017: International Journal of Psychophysiology
https://www.readbyqxmd.com/read/29223443/response-to-pioglitazone-in-patients-with-nonalcoholic-steatohepatitis-with-vs-without-type-2-diabetes
#6
Fernando Bril, Srilaxmi Kalavalapalli, Virginia C Clark, Romina Lomonaco, Consuelo Soldevila-Pico, I-Chia Liu, Beverly Orsak, Fermin Tio, Kenneth Cusi
BACKGROUND & AIMS: Pioglitazone is effective for long-term treatment of patients with nonalcoholic steatohepatitis (NASH) with prediabetes or type-2 diabetes. However, it is not clear how the presence of type-2 diabetes affects the drug's efficacy. We compared metabolic and histologic responses to pioglitazone in patients with NASH and prediabetes vs type-2 diabetes. METHODS: We performed a prospective study of adults with biopsy-proven NASH (52 with type-2 diabetes and 49 with prediabetes), enrolled from the general population of San Antonio, Texas from 2008 through 2014...
December 6, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29220534/effects-of-acupuncture-treatment-on-fibromyalgia-symptoms-serotonin-and-substance-p-levels-a-randomized-sham-and-placebo-controlled-clinical-trial
#7
Saliha Karatay, Sibel Caglar Okur, Hulya Uzkeser, Kadir Yildirim, Fatih Akcay
Objective: The aim of this study was to evaluate the effects of acupuncture treatment on serum levels of serotonin and substance P (SP) as well as on clinical parameters in patients with fibromyalgia (FM). Methods: This is a randomized controlled clinical trial. Seventy-five women with FM were randomized into one of three kinds of acupuncture treatment: real acupuncture group (AcG), sham acupuncture group (ShG), and simulated acupuncture group (SiG). Treatments were applied semiweekly for four weeks...
December 6, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29220105/less-fibrosis-in-elderly-subjects-supplemented-with-selenium-and-coenzyme-q10-a-mechanism-behind-reduced-cardiovascular-mortality
#8
Urban Alehagen, Jan Aaseth, Jan Alexander, Erland Svensson, Peter Johansson, Anders Larsson
BACKGROUND: In an intervention study where 221 healthy elderly persons received selenium and coenzyme Q10 as a dietary supplement, and 222 received placebo for 4 years we observed improved cardiac function and reduced cardiovascular mortality. As fibrosis is central in the aging process, we investigated the effect of the intervention on biomarkers of fibrogenic activity in a subanalysis of this intervention study. MATERIAL AND METHODS: In the present subanalysis 122 actively treated individuals and 101 controls, the effect of the treatment on eight biomarkers of fibrogenic activity were assessed...
December 8, 2017: BioFactors
https://www.readbyqxmd.com/read/29216779/the-plaque-and-gingivitis-inhibiting-capacity-of-a-commercially-available-mouthwash-containing-essential-oils-and-ethyl-lauroyl-arginate-a-randomized-clinical-trial
#9
Liv O Valør, Inghild K R Norton, Odd C Koldsland, Anne Merete Aass, Andrej M Grjibovski, Hans R Preus
OBJECTIVE: A commercially available mouth rinse with ethyl lauroyl arginate and essential oils claims to have better antimicrobial properties than the traditional essential oil products. The aim of this study was to compare the plaque and gingivitis inhibiting effect of the commercial product containing essential oils with ethyl lauroyl arginate with one placebo and one negative control in a modified experimental gingivitis model. MATERIALS AND METHODS: In three groups of healthy volunteers, experimental gingivitis was induced and monitored over 21 d, simultaneously treated with the commercial test solution, 21...
December 7, 2017: Acta Odontologica Scandinavica
https://www.readbyqxmd.com/read/29209154/effects-of-two-pre-workout-supplements-on-concentric-and-eccentric-force-production-during-lower-body-resistance-exercise-in-males-and-females-a-counterbalanced-double-blind-placebo-controlled-trial
#10
Grant M Tinsley, Matthew A Hamm, Amy K Hurtado, Austin G Cross, Jose G Pineda, Austin Y Martin, Victor A Uribe, Ty B Palmer
Background: Pre-workout supplements purportedly enhance feelings of energy, reduce fatigue and improve exercise performance. The purpose of this study was to examine the performance effects of caffeinated and non-caffeinated multi-ingredient pre-workout supplements. Methods: In a counterbalanced, double-blind, placebo-controlled design, eccentric and concentric force production during lower body resistance exercise on a mechanized squat device were assessed after supplement ingestion...
2017: Journal of the International Society of Sports Nutrition
https://www.readbyqxmd.com/read/29201115/effect-of-vitamin-d-supplementation-on-procalcitonin-as-prognostic-biomarker-in-patients-with-ventilator-associated-pneumonia-complicated-with-vitamin-d-deficiency
#11
Amir Ebrahim Miroliaee, Jamshid Salamzadeh, Shervin Shokouhi, Alireza Fatemi, Seyed Hossein Ardehali, Mohammad Reza Hajiesmaeili, Zahra Sahraei
Ventilator-associated pneumonia (VAP) is a common and serious problem that develops after more than 48 h of mechanical ventilation. Improving the activity of immune system with vitamin D, and its consequent impact on prognostic biomarkers of VAP was studied in the current study. A randomized double blind placebo controlled clinical trial was designed. A total of 46 patients with VAP, who were suffering from vitamin D deficiency, were randomly allocated into the study groups of placebo (n=22) and treatment (n=24) The treatment group received 300,000 units of intramuscular vitamin D...
2017: Iranian Journal of Pharmaceutical Research: IJPR
https://www.readbyqxmd.com/read/29199141/effects-of-amitriptyline-and-escitalopram-on-sleep-and-mood-in-patients-with-functional-dyspepsia
#12
Linda M Herrick, Michael Camilleri, Cathy D Schleck, Alan R Zinsmeister, Yuri A Saito, Nicholas J Talley
BACKGROUND & AIMS: Tricyclic antidepressants are effective in reducing symptoms of functional dyspepsia (FD). We performed a post hoc analysis of data from a previous randomized clinical trial to determine whether the benefits of an antidepressant on gastrointestinal symptoms in patients with FD were mediated by improving sleep or reducing anxiety. We explored the relationships between psychological measures, quality of sleep, and relief of symptoms. METHODS: We analyzed data from a multicenter, double-blind trial that evaluated the efficacy of antidepressants on symptoms of FD, from October 2006 through October 2012...
December 1, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29198951/prospective-evaluation-of-chronic-pain-disorders-and-treatments
#13
REVIEW
Charles J Vierck, C Richard Chapman
BACKGROUND: The incidence of chronic pain is variable among individuals who have sustained traumatic or surgical injury. Also, treatments for pain rarely are effective consistently for a procedure or agent, and no therapies are considered effective for pain that is chronic. NEW METHOD: Difficulties with standard methods for conducting clinical trials call attention to a need for protocols that provide a new understanding of the development of and control over chronic pain...
November 30, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/29198921/research-progress-of-capsaicin-responses-to-various-pharmacological-challenges
#14
REVIEW
Pompy Patowary, Manash Pratim Pathak, Kamaruz Zaman, P S Raju, Pronobesh Chattopadhyay
Capsaicin, a well known vanilloid, has shown evidence of an ample variety of biological effects which make it the target of extensive research ever since its identification. In spite of the fact that capsaicin causes health hazards in quite a few ways, yet, the verity cannot be ignored that capsaicin has several therapeutic implications. In patients with hypersensitive bladders, vesical instillation of 1 mM capsaicin markedly improved urinary frequency and urge incontinence. Again, administration of capsaicin favors an augmentation in lipid mobilization and a decrease in adipose tissue mass...
November 29, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29194849/somatotopic-effects-of-rtms-in-neuropathic-pain-a-comparison-between-stimulation-over-hand-and-face-motor-areas
#15
N Andre-Obadia, M Magnin, E Simon, L Garcia-Larrea
BACKGROUND: The therapeutic influence of somatotopic matching between pain topography and motor cortex stimulation site for neuropathic pain (NP) remains controversial. METHODS: Thirty-two patients suffering from NP involving the upper limb (n = 20) or the face (n = 12) received two high-frequency rTMS neuronavigated sessions targeting hand and face motor cortical areas, versus placebo. The cortical target was defined by anatomical MRI and EMG responses in all patients, completed in 19 of them by functional MRI...
December 1, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29192859/chemical-venous-thromboembolism-prophylaxis-in-neurosurgical-patients-an-updated-systematic-review-and-meta-analysis
#16
Nickalus R Khan, Prayash G Patel, John P Sharpe, Siang Liao Lee, Jeffrey Sorenson
OBJECTIVE Venous thromboembolism (VTE) is a common and potentially life-threatening complication. The risk of serious hemorrhagic complications when starting chemical prophylaxis for VTE prevention is a substantial concern for neurosurgeons. The objective of this study was to perform an updated systematic review and meta-analysis to determine if the rates of VTE and bleeding complications are different in patients undergoing chemoprophylaxis compared with placebo or mechanical prophylaxis alone following cranial or spinal procedures...
December 1, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29192015/the-european-medicines-agency-review-of-panobinostat-farydak-for-the-treatment-of-adult-patients-with-relapsed-and-or-refractory-multiple-myeloma
#17
REVIEW
Kyriaki Tzogani, Paula van Hennik, Ita Walsh, Pieter De Graeff, Annika Folin, Jan Sjöberg, Tomas Salmonson, Jonas Bergh, Edward Laane, Heinz Ludwig, Christian Gisselbrecht, Francesco Pignatti
On August 28, 2015, a marketing authorization valid through the European Union was issued for panobinostat, in combination with bortezomib and dexamethasone, for the treatment of adult patients with relapsed and/or refractory multiple myeloma who have received at least two prior regimens including bortezomib and an immunomodulatory agent (IMiD).Panobinostat is an orally available histone deacetylase (HDAC) inhibitor that inhibits the enzymatic activity of HDAC proteins at nanomolar concentrations. HDAC proteins catalyze the removal of acetyl groups from the lysine residues of histones and some nonhistone proteins...
November 30, 2017: Oncologist
https://www.readbyqxmd.com/read/29188222/effects-of-3-year-denosumab-treatment-on-hip-structure-in-japanese-postmenopausal-women-and-men-with-osteoporosis
#18
Teruki Sone, Naohiro Kon, Kenneth W Gaither, Naoki Okubo, Taisuke Osakabe, Yutaka Nakayama, Masao Fukunaga, Masako Ito, Toshitaka Nakamura
Denosumab, a human monoclonal antibody against RANK ligand, is shown to have strong anti-fracture effects in Japanese osteoporosis patients. However, there have been no data showing actions on Japanese bone architecture. Here we show that denosumab continuously improves several geometrical parameters calculated by hip structural analysis for 3 years. Compared to placebo, denosumab significantly increased bone mineral density, cortical thickness and cross sectional area in all of the three analyzed areas: the narrow neck, intertrochanter and femoral shaft...
December 2017: Bone Reports
https://www.readbyqxmd.com/read/29183898/pirfenidone-induced-hyponatraemia-insight-in-mechanism-risk-factor-and-management
#19
Leann Silhan, Panagis Galiatsatos, Justine Corwine, Sonye Danoff
Pirfenidone was approved in October 2014 in the USA for the treatment of idiopathic pulmonary fibrosis. Although not included in the adverse events published in the CAPACITY-1 and CAPACITY-2 or ASCEND trials, hyponatraemia was reported in supplementary data with rate of 3.4% in the active therapy arm versus 0.3% in the placebo arm. We performed a retrospective analysis of patients who were initiated on pirfenidone or nintedanib for the treatment of pulmonary fibrosis at our centre. Of the 52 patients who were started on pirfenidone, three (5...
November 27, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29183873/effect-of-chronic-liraglutide-therapy-and-its-withdrawal-on-time-to-post-challenge-peak-glucose-in-patients-with-type-2-diabetes
#20
Susan Tran, Caroline K Kramer, Bernard Zinman, Haysook Choi, Ravi Retnakaran
Delayed timing of peak serum glucose following an oral glucose challenge can predict declining beta-cell function and worsening glucose tolerance over time. Accordingly, post-challenge peak glucose is typically delayed in patients with type 2 diabetes (T2DM). However, little is known about the capacity of anti-diabetic medications to reverse this delay. Thus, we sought to evaluate the effect of the glucagon-like peptide-1 (GLP-1) agonist liraglutide on time to peak glucose in early T2DM. In this secondary analysis of a double-blind, placebo-controlled trial, 51 patients with T2DM of 2...
November 28, 2017: American Journal of Physiology. Endocrinology and Metabolism
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