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https://www.readbyqxmd.com/read/28340319/apigenin-reduces-nf-%C3%AE%C2%BAb-and-subsequent-cytokine-production-as-protective-effect-in-a-rodent-animal-model-of-lung-ischemia-reperfusion-injury
#1
Ioannis Bougioukas, Vassilios Didilis, Alexander Emmert, Ahmad F Jebran, Regina Waldmann-Beushausen, Tomislav Stojanovic, Friedrich A Schoendube, Bernhard C Danner
PURPOSE: Lung ischemia-reperfusion injury (LIRI) can complicate lung transplantation or cardiac surgery with cardiopulmonary bypass, increasing morbidity and mortality. In LIRI, pro-inflammatory cytokines are activated, reactive oxygen species are generated and nuclear factor-κB (NF-κB) is up-regulated, altering lung mechanics. We tested the effect of the flavonoid apigenin on a rodent model of LIRI. METHODS: Thirty-seven Wistar rats were subjected to LIRI with or without a single or double dose of apigenin...
March 24, 2017: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/28340244/bupropion-administration-increases-resting-state-functional-connectivity-in-dorso-medial-prefrontal-cortex
#2
Ewelina Rzepa, Zola Dean, Ciara McCabe
Background: Patients on the selective serotonergic re-uptake inhibitors (SSRI) like citalopram report emotional blunting. We have shown previously that citalopram reduces resting-state functional connectivity (RSFC) in healthy volunteers in a number of brain regions including the dorso-medial prefrontal cortex, which may be related to its clinical effects. Bupropion is a dopaminergic and noradrenergic re-uptake inhibitor (DNRI) and is not reported to cause emotional blunting. However how bupropion affects RSFC in healthy controls remains unknown...
March 11, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28335000/better-than-sham-a-double-blind-placebo-controlled-neurofeedback-study-in-primary-insomnia
#3
Manuel Schabus, Hermann Griessenberger, Maria-Teresa Gnjezda, Dominik P J Heib, Malgorzata Wislowska, Kerstin Hoedlmoser
Neurofeedback training builds upon the simple concept of instrumental conditioning, i.e. behaviour that is rewarded is more likely to reoccur, an effect Thorndike referred to as the 'law of effect'. In the case of neurofeedback, information about specific electroencephalographic activity is fed back to the participant who is rewarded whenever the desired electroencephalography pattern is generated. If some kind of hyperarousal needs to be addressed, the neurofeedback community considers sensorimotor rhythm neurofeedback as the gold standard...
February 23, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28331914/effects-and-mechanisms-of-a-new-multivitamin-on-chronic-metabolic-syndromes-and-aging
#4
Su-Xi Wu, Xuewei Jiang, Yu-Ying Liu, Lin-Feng Chen, Jun Tao
BACKGROUND: Increased occurrence of chronic syndromes has prompted researchers to investigate and develop drugs and methods for controlling chronic syndromes with a view to improve human health and reduce early aging. MATERIAL AND METHODS: Human trials: After the allotted multivitamin pills or placebo pills had been taken for a stipulated period of about 2 months, the volunteers filled out feedback forms on curative effects of the pills in line with the health examination reports...
2017: African Journal of Traditional, Complementary, and Alternative Medicines: AJTCAM
https://www.readbyqxmd.com/read/28331861/the-effect-of-vitamin-d-administration-on-intracellular-adhesion-molecule-1-and-vascular-cell-adhesion-molecule-1-levels-in-hemodialysis-patients-a-placebo-controlled-double-blinded-clinical-trial
#5
Afsoon Emami Naeini, Firouzeh Moeinzadeh, Sahar Vahdat, Akbar Ahmadi, Zahra Parin Hedayati, Safoora Shahzeidi
OBJECTIVE: Vitamin D deficiency is quite common among end-stage renal disease (ESRD) patients, and Vitamin D administration could reduce morbidity and mortality in these patients through different mechanisms. Cardiovascular diseases are the most common cause of mortality in these patients that are caused by vascular injuries. Intracellular adhesion molecule (ICAM) and vascular cell adhesion molecule (VCAM) are vascular inflammation indicators. The goal of this study is to find the effect of Vitamin D administration on ICAM-1 and VCAM-1 serum levels in ESRD patients on hemodialysis...
January 2017: Journal of Research in Pharmacy Practice
https://www.readbyqxmd.com/read/28327134/the-effect-of-intra-articular-botulinum-toxin-a-on-substance-p-prostaglandin-e2-and-tumor-necrosis-factor-alpha-in-the-canine-osteoarthritic-joint
#6
Helka M Heikkilä, Anna K Hielm-Björkman, John F Innes, Outi M Laitinen-Vapaavuori
BACKGROUND: Recently, intra-articular botulinum toxin A (IA BoNT A) has been shown to reduce joint pain in osteoarthritic dogs. Similar results have been reported in human patients with arthritis. However, the mechanism of the antinociceptive action of IA BoNT A is currently not known. The aim of this study was to explore this mechanism of action by investigating the effect of IA BoNT A on synovial fluid (SF) and serum substance P (SP), prostaglandin E2 (PGE2), and tumor necrosis factor alpha (TNF-α) in osteoarthritic dogs...
March 21, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28326925/interaction-of-acupuncture-treatment-and-manipulation-laterality-modulated-by-the-default-mode-network
#7
Xuan Niu, Ming Zhang, Zhenyu Liu, Lijun Bai, Chuanzhu Sun, Shan Wang, Xiaocui Wang, Zhen Chen, Hongyan Chen, Jie Tian
Appropriate selection of ipsilateral or contralateral electroacupuncture (corresponding to the pain site) plays an important role in reaching its better curative effect; however, the involving brain mechanism still remains unclear. Compared with the heat pain model generally established in previous study, capsaicin pain model induces reversible cutaneous allodynia and is proved to be better simulating aspects of clinical nociceptive and neuropathic pain. In the current study, 24 subjects were randomly divided into two groups with a 2 × 2 factorial design: laterality (ipsi- or contralateral side, inter-subject) × treatment with counter-balanced at an interval of one week (verum and placebo electroacupuncture, within-subject)...
January 2017: Molecular Pain
https://www.readbyqxmd.com/read/28326290/effects-of-probiotic-supplementation-on-lipid-profile-of-women-with-rheumatoid-arthritis-a-randomized-placebo-controlled-clinical-trial
#8
Elnaz Vaghef-Mehrabany, Leila Vaghef-Mehrabany, Mohammad Asghari-Jafarabadi, Aziz Homayouni-Rad, Karim Issazadeh, Beitullah Alipour
Background: Probiotics are live beneficial microorganisms which may exert hypolipidemic effects through many mechanisms. Lipid profile disturbances are frequently reported in rheumatoid arthritis (RA) patients. The objective of this study was to evaluate the effects of Lactobacillus casei on serum lipids of RA women. Methods: In the present parallel randomized double-blind placebo-controlled clinical trial, 60 RA patients were recruited and divided into 2 groups. They received either a daily capsule containing 10(8) CFU of L...
2017: Health Promotion Perspectives
https://www.readbyqxmd.com/read/28324705/more-pain-more-gain-blocking-the-opioid-system-boosts-adaptive-cognitive-control
#9
Henk van Steenbergen, Daniel H Weissman, Dan J Stein, Susan Malcolm-Smith, Jack van Honk
The ability to adaptively increase cognitive control in response to cognitive challenges is crucial for goal-directed behavior. Recent findings suggest that aversive arousal triggers adaptive increases of control, but the neurochemical mechanisms underlying these effects remain unclear. Given the known contributions of the opioid system to hedonic states, we investigated whether blocking this system increases adaptive control modulations. To do so, we conducted a double-blind, placebo-controlled psychopharmacological study (n=52 females) involving a Stroop-like task...
March 7, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28322235/impact-of-tryptophan-depletion-on-executive-system-function-during-menopause-is-moderated-by-childhood-adversity
#10
Sheila Shanmugan, James Loughead, Wen Cao, Mary D Sammel, Theodore D Satterthwaite, Kosha Ruparel, Ruben C Gur, C Neill Epperson
Many healthy women with no history of cognitive dysfunction experience subjective executive difficulties during menopause. Preclinical literature suggests latent effects of early life adversity on serotonin function may play a role in this phenomenon. However, evidence in human participants regarding the mechanisms by which loss of estradiol contributes to this vulnerability is lacking. Here we examined the impact of tryptophan depletion (TD) and adverse childhood experiences (ACE) on brain activation during a working memory task in menopausal women...
March 21, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28321847/antenatal-corticosteroids-for-accelerating-fetal-lung-maturation-for-women-at-risk-of-preterm-birth
#11
REVIEW
Devender Roberts, Julie Brown, Nancy Medley, Stuart R Dalziel
BACKGROUND: Respiratory morbidity including respiratory distress syndrome (RDS) is a serious complication of preterm birth and the primary cause of early neonatal mortality and disability. While researching the effects of the steroid dexamethasone on premature parturition in fetal sheep in 1969, Liggins found that there was some inflation of the lungs of lambs born at gestations at which the lungs would be expected to be airless. Liggins and Howie published the first randomised controlled trial in humans in 1972 and many others followed...
March 21, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28321318/does-the-model-of-additive-effect-in-placebo-research-still-hold-true-a-narrative-review
#12
Katja Boehm, Bettina Berger, Ulrich Weger, Peter Heusser
Personalised and contextualised care has been turned into a major demand by people involved in healthcare suggesting to move toward person-centred medicine. The assessment of person-centred medicine can be most effectively achieved if treatments are investigated using 'with versus without' person-centredness or integrative study designs. However, this assumes that the components of an integrative or person-centred intervention have an additive relationship to produce the total effect. Beecher's model of additivity assumes an additive relation between placebo and drug effects and is thus presenting an arithmetic summation...
March 2017: JRSM Open
https://www.readbyqxmd.com/read/28318471/adjunctive-n-acetylcysteine-in-depression-exploration-of-interleukin-6-c-reactive-protein-and-brain-derived-neurotrophic-factor
#13
Kyoko Hasebe, Laura Gray, Chiara Bortolasci, Bruna Panizzutti, Mohammadreza Mohebbi, Srisaiyini Kidnapillai, Briana Spolding, Ken Walder, Michael Berk, Gin Malhi, Seetal Dodd, Olivia M Dean
OBJECTIVE: This study aimed to explore effects of adjunctive N-acetylcysteine (NAC) treatment on inflammatory and neurogenesis markers in unipolar depression. METHODS: We embarked on a 12-week clinical trial of NAC (2000 mg/day compared with placebo) as an adjunctive treatment for unipolar depression. A follow-up visit was conducted 4 weeks following the completion of treatment. We collected serum samples at baseline and the end of the treatment phase (week 12) to determine changes in interleukin-6 (IL6), C-reactive protein (CRP) and brain-derived neurotrophic factor (BDNF) following NAC treatment...
March 20, 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/28317031/effect-of-tranexamic-acid-on-coagulation-and-fibrinolysis-in-women-with-postpartum-haemorrhage-woman-etac-protocol-and-statistical-analysis-plan-for-a-randomized-controlled-trial
#14
Haleema Shakur, Bukola Fawole, Modupe Kuti, Oladapo Olayemi, Adenike Bello, Olayinka Ogunbode, Taiwo Kotila, Chris O Aimakhu, Sumaya Huque, Meghann Gregg, Ian Roberts
Background: Postpartum haemorrhage (PPH) is a leading cause of maternal death. Tranexamic acid has the potential to reduce bleeding and a large randomized controlled trial of its effect on maternal health outcomes in women with PPH (The WOMAN trial) is ongoing. We will examine the effect of tranexamic acid on fibrinolysis and coagulation in a subset of WOMAN trial participants. Methods. Adult women with clinically diagnosed primary PPH after vaginal or caesarean delivery are eligible for inclusion in the WOMAN trial...
December 16, 2016: Wellcome Open Res
https://www.readbyqxmd.com/read/28316762/mesalazine-has-no-effect-on-mucosal-immune-biomarkers-in-patients-with-diarrhea-dominant-irritable-bowel-syndrome-referred-to-shariati-hospital-a-randomized-double-blind-placebo-controlled-trial
#15
Mohammad Reza Ghadir, Mehri Poradineh, Masoud Sotodeh, Reza Ansari, Shadi Kolahdoozan, Ahmad Hormati, Mohammad Hosein Yousefi, Samaneh Mirzaei, Homayoon Vahedi
BACKGROUND Intestinal mast cells may cause gastrointestinal symptoms in patients with diarrhea-dominant irritable bowel syndrome (IBS). The objective of this study was to determine the effect of mesalazine on the number of lamina propria mast cells and clinical manifestations of patients with diarrhea-dominant IBS referred to Shariati Hospital affiliated to Tehran University of Medical Sciences. METHODS This was a randomized placebo-controlled double-blind trial conducted on 49 patients with diarrhea-dominant IBS...
January 2017: Middle East Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28314859/effects-of-cetp-inhibition-with-anacetrapib-on-metabolism-of-vldl-tg-and-plasma-apolipoproteins-c-ii-c-iii-and-e
#16
John S Millar, Michael E Lassman, Tiffany Thomas, Rajasekhar Ramakrishnan, Patricia Jumes, Richard L Dunbar, Emile M deGoma, Amanda L Baer, Wahida Karmally, Daniel S Donovan, Hashmi Rafeek, John A Wagner, Stephen Holleran, Joseph Obunike, Yang Liu, Soumia Aoujil, Taylor Standiford, David E Gutstein, Henry N Ginsberg, Daniel J Rader, Gissette Reyes-Soffer
Cholesteryl ester transfer protein (CETP) mediates the transfer of HDL cholesteryl esters(CE) for TG in VLDL/LDL. CETP inhibition, with anacetrapib, increases HDL-cholesterol(C), reduces LDL-C and lowers TG levels. This study describes the mechanisms responsible for TG lowering by examining the kinetics of VLDL-TG and apolipoproteins (apo) C-II, C-III, and E. Hypercholesterolemic subjects were randomized to either placebo(N=10) or atorvastatin 20 mg/qd(N=29) for 4 weeks(period 1) followed by 8-weeks of anacetrapib, 100 mg/qd(period 2)...
March 17, 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/28302903/differential-effects-of-dapagliflozin-on-cardiovascular-risk-factors-at-varying-degrees-of-renal-function
#17
Sergei Petrykiv, C David Sjöström, Peter J Greasley, John Xu, Frederik Persson, Hiddo J L Heerspink
BACKGROUND AND OBJECTIVE: Sodium glucose cotransporter 2 inhibition with dapagliflozin decreases hemoglobin A1c (HbA1c), body weight, BP, and albuminuria (urinary albumin-to-creatinine ratio). Dapagliflozin also modestly increases hematocrit, likely related to osmotic diuresis/natriuresis. Prior studies suggest that the HbA1c-lowering effects of dapagliflozin attenuate at lower eGFR. However, effects on other cardiovascular risk factors at different eGFR levels are incompletely understood...
March 16, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/28298783/study-of-effect-of-magnesium-sulphate-in-management-of-acute-organophosphorous-pesticide-poisoning
#18
H N Vijayakumar, Sudheesh Kannan, C Tejasvi, Devika Rani Duggappa, K M Veeranna Gowda, S S Nethra
BACKGROUND: Organophosphorus compound poisoning (OPCP) is a major public health problem in developing countries like India. Atropine and oximes remain the main-stay of management. Magnesium sulfate (MgSO4) has shown benefit in the management of OPCP. AIMS: This study was designed to assess the effect of MgSO4 on outcome in OPCP patients admitted to Intensive Care Unit (ICU). SETTINGS AND DESIGN: Double-blind prospective randomized clinical trial in an ICU of tertiary care institution...
January 2017: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/28294070/dutasteride-in-androgenetic-alopecia-an-update
#19
Tasleem Arif, Konchok Dorjay, Mohammad Adil, Marwa Sami
BACKGROUND: Androgenetic alopecia is a common condition characterized by thinning of scalp hair. Conversion of testosterone to dihydrotestosterone, a more potent androgen, by the enzyme 5-a-reductase is responsible for underlying pathogenesis. Dutasteride, a synthetic 4-azasteroid, is a selective and competitive inhibitor of both type-1 and type-2 isoenzymes of 5-alpha-reductase. Finasteride and minoxidil are the only approved drugs for androgenetic alopecia. Dutasteride has been demonstrated to be effective in several randomized, double-blind, placebo controlled trials in androgenetic alopecia...
March 10, 2017: Current Clinical Pharmacology
https://www.readbyqxmd.com/read/28289539/contextually-aided-recovery-care-a-scientific-theory-for-innate-healing
#20
Dave Newell, Lise R Lothe, Timothy J L Raven
BACKGROUND: The chiropractic profession emerged when scientific explanations for causes of health and disease were still in infancy and the co-existence of notions such as innate healing and vitalism were perhaps admissible within such a historical context. Notwithstanding, within the scientific culture of the 21(st) Century all healthcare paradigms require evidential support which in regard these early concepts are in large part, absent. Nevertheless, a large body of emerging scientific evidence supports the existence of innate healing phenomena that may explain a plethora of clinical outcomes observed during chiropractic care...
2017: Chiropractic & Manual Therapies
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