Yongfeng Yang, Xueyan Jin, Yongjiang Xue, Xue Li, Yi Chen, Ning Kang, Wei Yan, Peng Li, Xiaoge Guo, Binbin Luo, Yan Zhang, Qing Liu, Han Shi, Luwen Zhang, Xi Su, Bing Liu, Lin Lu, Luxian Lv, Wenqiang Li
Antipsychotic drug treatment for schizophrenia (SZ) can alter brain structure and function, but it is unclear if specific regional changes are associated with treatment outcome. Therefore, we examined the effects of antipsychotic drug treatment on regional grey matter (GM) density, white matter (WM) density, and functional connectivity (FC) as well as associations between regional changes and treatment efficacy. SZ patients (n = 163) and health controls (HCs) (n = 131) were examined by structural magnetic resonance imaging (sMRI) at baseline, and a subset of SZ patients (n = 77) were re-examined after 8 weeks of second-generation antipsychotic treatment to assess changes in regional GM and WM density...
April 3, 2024: NeuroImage: Clinical