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https://www.readbyqxmd.com/read/29338236/detection-of-the-cytotoxic-penitrems-a-f-in-cheese-from-the-european-single-market-eu-by-hplc-ms-ms
#1
Svetlana Kalinina, Annika Jagels, Sebastian Hickert, Lucas Maciel Mauriz Marques, Benedikt Cramer, Hans-Ulrich Humpf
Penitrems are fungal indole diterpene derived tremorgenic secondary metabolites, which are mainly produced by Penicillium spp. Several cases of intoxications with penitrems and subsequent occurrences of penitrem A in foodstuff underline the need for reliable quantitation methods for the detection of these mycotoxins in food. In this study, a simple and fast HPLC-MS/MS method for the quantitative analysis of penitrems A-F in cheese was developed. Therefore, penitrems A-F were isolated from Penicillium crustosum as analytical reference standards...
January 16, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29337658/versicolorin-a-is-a-potential-indicator-of-aflatoxin-contamination-in-the-granary-stored-corn
#2
Daling Liu, Shuyao Zhang, Hao Wang, Min Yang, Dongsheng Yao, Chunfang Xie
The objective of this study was to evaluate the feasibility of the predictive monitoring of aflatoxin B1 (AFB1) under granary conditions, since mycotoxin contamination of the stored grain represents an important issue. Using the storage test, we investigated the relationship between versicolorin A (Ver A, an intermediate in AFB1 biosynthesis) levels and the levels of aflatoxigenic fungi, and their relationship with aflatoxin production. All samples, except for one, were found to be contaminated with aflatoxigenic fungi using PCR analyses, while their AFB1 levels were not detectable before the storage test using an ELISA method with an LOD of 2 μg/kg...
January 16, 2018: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/29337657/the-prevalence-of-deoxynivalenol-and-its-derivatives-in-the-spring-wheat-grain-from-different-agricultural-production-systems-in-lithuania
#3
Sigita Janaviciene, Audrone Mankeviciene, Skaidre Suproniene, Yuliia Kochiieru, Ilona Keriene
Deoxynivalenol (DON) together with two acetylated derivatives, 3-acetyldeoxynivalenol (3-ADON) and 15-acetyldeoxynivalenol (15-ADON) occurs in cereal grains and their products. Co-occurrence of DON and acetylated derivatives in cereal grain is detected worldwide. Until now, DON and its derivatives have been considered equally toxic by health authorities. In this study, we analysed 103 samples of spring wheat grain, originating from the fields of different production systems in Lithuania, for the co-occurrence of type-B trichothecenes (DON, 3-ADON, 15-ADON)...
January 16, 2018: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/29337587/use-of-lactic-acid-bacteria-and-yeasts-to-reduce-exposure-to-chemical-food-contaminants-and-toxicity
#4
Gabriela Matuoka Chiocchetti, Carlos Jadán-Piedra, Vicente Monedero, Manuel Zúñiga, Dinoraz Vélez, Vicenta Devesa
Chemical contaminants that are present in food pose a health problem and their levels are controlled by national and international food safety organizations. Despite increasing regulation, foods that exceed legal limits reach the market. In Europe, the number of notifications of chemical contamination due to pesticide residues, mycotoxins and metals is particularly high. Moreover, in many parts of the world, drinking water contains high levels of chemical contaminants owing to geogenic or anthropogenic causes...
January 16, 2018: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/29337187/metabolomics-reveals-that-dietary-xenoestrogens-alter-cellular-metabolism-induced-by-palbociclib-letrozole-combination-cancer-therapy
#5
Benedikt Warth, Philipp Raffeiner, Ana Granados, Tao Huan, Mingliang Fang, Erica M Forsberg, H Paul Benton, Laura Goetz, Caroline H Johnson, Gary Siuzdak
Recently, the palbociclib/letrozole combination therapy was granted accelerated US FDA approval for the treatment of estrogen receptor (ER)-positive breast cancer. Since the underlying metabolic effects of these drugs are yet unknown, we investigated their synergism at the metabolome level in MCF-7 cells. As xenoestrogens interact with the ER, we additionally aimed at deciphering the impact of the phytoestrogen genistein and the estrogenic mycotoxin zearalenone. A global metabolomics approach was applied to unravel metabolite and pathway modifications...
January 10, 2018: Cell Chemical Biology
https://www.readbyqxmd.com/read/29336725/adaptability-of-mitosporic-stage-in-sphaerodes-mycoparasitica-towards-its-mycoparasitic-polyphagous-lifestyle
#6
Vladimir Vujanovic, Seon Hwa Kim
Sphaerodes mycoparasitica Vuj. is a Fusarium-specific mycoparasite. Some recent discoveries recognize its biotrophic polyphagous lifestyle as an interesting biocontrol property against a broad spectrum of mycotoxigenic Fusarium hosts. Secondary metabolites such as mycotoxins produced by Fusarium spp. may play an important role in the signaling process, allowing an early mycoparasite-host recognition. A multiple-paper-disc assay has been conducted to test S. mycoparasitica hyphal adaptability to filtrates of 12 Fusarium spp...
November 17, 2017: Mycologia
https://www.readbyqxmd.com/read/29331731/deoxynivalenol-gut-microbiota-and-immunotoxicity-a-potential-approach
#7
REVIEW
Yuxiao Liao, Zhao Peng, Liangkai Chen, Andreas K Nüssler, Liegang Liu, Wei Yang
Deoxynivalenol (DON, vomitoxin) is the most frequent mycotoxin in grains and grain products. DON contamination in fodder and food is a serious threat for health, since it impairs the immune and gastrointestinal systems of both human and animals. Gut microbiota seems to play a more and more important part in human and animals' health according to related researches. Previous studies implied some associations among gut microbiota, DON and immune system. For example, DON affects immune system as well as the composition and abundance of gut microbiota, and the latter influences immune system as well...
January 10, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29331673/diversity-of-aspergillus-section-nigri-on-the-surface-of-vitis-labrusca-and-its-hybrid-grapes
#8
Larissa de Souza Ferranti, Maria Helena P Fungaro, Fernanda Pelisson Massi, Josué José da Silva, Rafael Elias Silva Penha, Jens Christian Frisvad, Marta Hiromi Taniwaki, Beatriz Thie Iamanaka
This study investigated the presence of Aspergillus species belonging to Aspergillus section Nigri on Vitis labrusca and its hybrid grapes grown in Brazil. The ability of the fungi isolates to produce ochratoxin A (OTA) and fumonisin B2 (FB2) as well as the presence of these mycotoxins in the grapes were also studied. Eighty-eight samples were collected from the main grape producing states in Brazil: Rio Grande do Sul (n=30), Pernambuco (n=21), São Paulo (n=21) and Paraná (n=16). The highest average contamination level by A...
January 4, 2018: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/29329875/hydrolysers-of-modified-mycotoxins-in-maize-%C3%AE-amylase-and-cellulase-induce-an-underestimation-of-the-total-aflatoxin-content
#9
Arnau Vidal, Sonia Marín, Vicente Sanchis, Sarah De Saeger, Marthe De Boevre
Aflatoxins are the most potent genotoxic and carcinogenic mycotoxins. To date, research has only focused on the presence of free aflatoxins in agricultural commodities. Therefore, the main objective of this study was to investigate the occurrence of possible modified aflatoxins in maize. Different hydrolysis methods were applied to convert modified mycotoxins into their free aflatoxins. Eighteen aflatoxin-contaminated maize samples were incubated with potassium hydroxide, trifluoromethanesulfonic acid and several enzymes to induce hydrolysis...
May 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29329852/an-integrated-in-silico-in-vitro-approach-to-assess-the-xenoestrogenic-potential-of-alternaria-mycotoxins-and-metabolites
#10
Luca Dellafiora, Benedikt Warth, Verena Schmidt, Giorgia Del Favero, Hannes Mikula, Johannes Fröhlich, Doris Marko
Xenoestrogenic mycotoxins may contaminate food and feed posing a public health issue. Besides the zearalenone group, the Alternaria toxin alternariol (AOH) has been described as a potential mycoestrogen. However, the estrogenicity of Alternaria toxins is still largely overlooked and further data are needed to better describe the group toxicity. In the frame of risk assessment, mixed in silico/in vitro approaches already proved to be effective first-line analytical tools. An integrated in silico/in vitro approach was used to investigate the effects of metabolic and chemical modifications on the estrogenicity of AOH...
May 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29329707/simultaneous-determination-of-117-pesticides-and-30-mycotoxins-in-raw-coffee-without-clean-up-by-lc-esi-ms-ms-analysis
#11
Bárbara Reichert, André de Kok, Ionara Regina Pizzutti, Jos Scholten, Carmem Dickow Cardoso, Martien Spanjer
This paper describes the optimization and validation of an acetonitrile based method for simultaneous extraction of multiple pesticides and mycotoxins from raw coffee beans followed by LC-ESI-MS/MS determination. Before extraction, the raw coffee samples were milled and then slurried with water. The slurried samples were spiked with two separate standard solutions, one containing 131 pesticides and a second with 35 mycotoxins, which were divided into 3 groups of different relative concentration levels. Optimization of the QuEChERS approach included performance tests with acetonitrile acidified with acetic acid or formic acid, with or without buffer and with or without clean-up of the extracts before LC-ESI-MS/MS analysis...
April 3, 2018: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29328967/mycotoxin-production-of-alternaria-strains-isolated-from-korean-barley-grains-determined-by-lc-ms-ms
#12
Thuong T T Nguyen, Jueun Kim, Sun Jeong Jeon, Chul Won Lee, Naresh Magan, Hyang Burm Lee
Twenty-four Alternaria strains were isolated from barley grain samples. These strains were screened for the production of mycotoxins on rice medium using thin layer chromatography. All 24 strains produced at least one of the five mycotoxins (ALT, AOH, ATX-I, AME, and TeA). Three representative strains, namely EML-BLDF1-4, EML-BLDF1-14, and EML-BLDF1-18, were further analyzed using a new LC-MS/MS-based mycotoxin quantification method. This method was used to detect and quantify Alternaria mycotoxins. We used positive ion electrospray mass spectrometry with multiple reaction mode (MRM) for the simultaneous quantification of various Alternaria mycotoxins produced by these strains...
January 3, 2018: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/29324288/description-of-an-orthologous-cluster-of-ochratoxin-a-biosynthetic-genes-in-aspergillus-and-penicillium-species-a-comparative-analysis
#13
Jessica Gil-Serna, Marta García-Díaz, María Teresa González-Jaén, Covadonga Vázquez, Belén Patiño
Ochratoxin A (OTA) is one of the most important mycotoxins due to its toxic properties and worldwide distribution which is produced by several Aspergillus and Penicillium species. The knowledge of OTA biosynthetic genes and understanding of the mechanisms involved in their regulation are essential. In this work, we obtained a clear picture of biosynthetic genes organization in the main OTA-producing Aspergillus and Penicillium species (A. steynii, A. westerdijkiae, A. niger, A. carbonarius and P. nordicum) using complete genome sequences obtained in this work or previously available on databases...
January 3, 2018: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/29320435/updated-overview-of-infrared-spectroscopy-methods-for-detecting-mycotoxins-on-cereals-corn-wheat-and-barley
#14
REVIEW
Cecile Levasseur-Garcia
Each year, mycotoxins cause economic losses of several billion US dollars worldwide. Consequently, methods must be developed, for producers and cereal manufacturers, to detect these toxins and to comply with regulations. Chromatographic reference methods are time consuming and costly. Thus, alternative methods such as infrared spectroscopy are being increasingly developed to provide simple, rapid, and nondestructive methods to detect mycotoxins. This article reviews research conducted over the last eight years into the use of near-infrared and mid-infrared spectroscopy to monitor mycotoxins in corn, wheat, and barley...
January 10, 2018: Toxins
https://www.readbyqxmd.com/read/29317881/neospora-caninum-infection-during-the-first-gestation-of-holstein-heifers-that-consume-food-contaminated-naturally-with-zearalenone-under-field-conditions
#15
Carlos Cruz-Vázquez, Juan Vital-Gutiérrez, Leticia Medina-Esparza, Luis Ortega-Mora, Arturo Valdivia-Flores, Teódulo Quezada-Tristán, Agustín Orihuela-Trujillo
Background: This work studied the natural infection of Neospora caninum during the first gestation of heifers in a dairy farm in animals consuming a ration co ntaminated naturally with Zearalenone (ZEA), and to find out effect of mycotoxin in the levels of estrogen (E) and progesterone (P4) and that's relation to the infection to N. caninum and in the abortions. Methods: The study was conducted in a dairy farm located in El Llano municipality, in Aguascalientes, Mexico, in 2013...
October 2017: Iranian Journal of Parasitology
https://www.readbyqxmd.com/read/29315887/all-in-one-electroactive-nanocarbon-as-simultaneous-platform-and-label-for-single-step-biosensing
#16
Zhao Xuan Cheng, Alessandra Bonanni
We demonstrate here that an electroactive nanocarbon material can simultaneously work as both platform and label for the detection of mycotoxins. The versatility of the material for the immobilization of biorecognition elements was combined with its ability to provide an intrinsic electrochemical signal upon reduction of the oxygen functionalities on its surface. The intensity of peak current reflects the availability of oxygen functionalities for reduction, which can be directly correlated to the specific biorecognition event...
January 5, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29313386/detoxification-of-fusarium-contaminated-maize-with-sodium-sulphite-in-vivo-efficacy-with-special-emphasis-on-mycotoxin-residues-and-piglet-health
#17
Anh Tuan Tran, Jeannette Kluess, Andreas Berk, Marleen Paulick, Jana Frahm, Dian Schatzmayr, Janine Winkler, Susanne Kersten, Sven Dänicke
A feeding experiment with piglets was performed to examine the efficacy of a wet preservation of Fusarium (FUS)-contaminated maize with sodium sulphite (SoS) based on deoxynivalenol (DON) and zearalenone (ZEN) residue levels in urine, bile and liquor and health traits of piglets. For this purpose, 80 castrated male piglets (7.57 ± 0.92 kg BW) were assigned to four treatment groups: CON- (control diet, with 0.09 mg DON and <0.01 mg ZEN/kg diet), CON+ (diet CON-, wet-preserved with 5 g SoS/kg maize; containing 0...
February 2018: Archives of Animal Nutrition
https://www.readbyqxmd.com/read/29310242/competitive-horseradish-peroxidase-linked-aptamer-assay-for-sensitive-detection-of-aflatoxin-b1
#18
Linlin Sun, Qiang Zhao
Aflatoxin B1 (AFB1) is one of highly toxic mycotoxins and a known human carcinogen. The frequent contamination of AFB1 in food products and large health risk of AFB1 have raised global concerns. Sensitive detection of AFB1 is of vital importance and highly demanded. Herein, we reported a competitive horseradish peroxidase (HRP)-linked aptamer assay for AFB1, combining the advantages of aptamer for affinity binding and enzyme label for signal amplification. In this assay, free AFB1 in solution competed with a covalent conjugate of bovine serum albumin-AFB1 (BSA-AFB1) coated on the wells of microplate in binding to the HRP-labeled aptamer probe...
March 1, 2018: Talanta
https://www.readbyqxmd.com/read/29309824/ochratoxin-a-toxicity-oxidative-stress-and-metabolism
#19
REVIEW
Yanfei Tao, Shuyu Xie, Fanfan Xu, Yanxin Wang, Dongmei Chen, Yuanhu Pan, Lingli Huang, Dapeng Peng, Xu Wang, Zonghui Yuan
Ochratoxin A (OTA) is a widespread mycotoxin commonly found as a corn contaminant. It has been shown to be nephrotoxic, hepatotoxic, teratogenic and immunotoxic to several species of animals and to cause kidney and liver tumors in mice and rats. The focus of this article is primarily intended to summarize the progress in research associated with oxidative stress as a plausible mechanism for OTA-induced toxicity as well as its metabolism. The present review shows that studies have been carried out for decades to elucidate the production of reactive oxygen species (ROS) and oxidative stress as a result of OTA treatment and have correlated them with various types of OTA toxicity, indicating that oxidative stress plays critical roles in the toxicity of OTA...
January 5, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29307701/toxicological-effects-of-regulated-mycotoxins-and-persistent-organochloride-pesticides-in-vitro-cytotoxic-assessment-of-single-and-defined-mixtures-on-ma-10-murine-leydig-cell-line
#20
Ukpai A Eze, John Huntriss, Michael N Routledge, Yun Yun Gong
Epidemiological studies show that there is global decline in male fertility primarily as a result of poor sperm quality and this is attributed to exposure to endocrine disrupting chemicals (EDCs) in the environment, food and pharmaceutical products, including mycotoxins and pesticides. The Leydig cells in the male testes are responsible for producing androgens, hormones that play major roles in male development and reproductive function. Therefore, any toxin that affects the function and morphology of the Leydig cells may result in sub-fertility or infertility...
January 4, 2018: Toxicology in Vitro: An International Journal Published in Association with BIBRA
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