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Heather Kelly, Gaven Lin, Narayan Sankaran, Jing Xia, Sridhar Kalluri, Simon Carlile
OBJECTIVE: To develop, in Australian English, the first mixed-gender, multi-talker matrix sentence test. DESIGN: Speech material consisted of a 50-word base matrix whose elements can be combined to form sentences of identical syntax but unpredictable content. Ten voices (five female and five male) were recorded for editing and preliminary level equalization. Elements were presented as single-talker sentences-in-noise during two perceptual tests: an optimization phase that provided the basis for further level correction, and an evaluation phase that perceptually validated those changes...
October 19, 2016: International Journal of Audiology
Udaya C Kalluri, Raja S Payyavula, Jessy L Labbé, Nancy Engle, Garima Bali, Sara S Jawdy, Robert W Sykes, Mark Davis, Arthur Ragauskas, Gerald A Tuskan, Timothy J Tschaplinski
A greater understanding of the genetic regulation of plant cell wall remodeling and the impact of modified cell walls on plant performance is important for the development of sustainable biofuel crops. Here, we studied the impact of down-regulating KORRIGAN-like cell wall biosynthesis genes, belonging to the endo-β-1,4-glucanase gene family, on Populus growth, metabolism and the ability to interact with symbiotic microbes. The reductions in cellulose content and lignin syringyl-to-guaiacyl unit ratio, and increase in cellulose crystallinity of cell walls of PdKOR RNAi plants corroborated the functional role of PdKOR in cell wall biosynthesis...
2016: Frontiers in Plant Science
Kalluri Chinna Rao, M Madhusudhan Babu
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
Kalluri Chinna Rao, M Madhusudhana Babu
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
Björn Tampe, Ulrike Steinle, Désirée Tampe, Julienne L Carstens, Peter Korsten, Elisabeth M Zeisberg, Gerhard A Müller, Raghu Kalluri, Michael Zeisberg
Acute kidney injury (AKI) and progressive chronic kidney disease (CKD) are intrinsically tied syndromes. In this regard, the acutely injured kidney often does not achieve its full regenerative capacity and AKI directly transitions into progressive CKD associated with tubulointerstitial fibrosis. Underlying mechanisms of such AKI-to-CKD progression are still incompletely understood and specific therapeutic interventions are still elusive. Because epigenetic modifications play a role in maintaining tissue fibrosis, we used a murine model of ischemia-reperfusion injury to determine whether aberrant promoter methylation of RASAL1 contributes causally to the switch between physiological regeneration and tubulointerstitial fibrogenesis, a hallmark of AKI-to-CKD progression...
September 27, 2016: Kidney International
Jhansi R Kalluri, Roberto Gonzalez-Rodriguez, Phil S Hartman, Armando Loni, Leigh T Canham, Jeffery L Coffer
Multiple new approaches to tackle multidrug resistant infections are urgently needed and under evaluation. One nanotechnology-based approach to delivering new relevant therapeutics involves silicon accumulator plants serving as a viable silicon source in green routes for the fabrication of the nanoscale drug delivery carrier porous silicon (pSi). If the selected plant leaf components contain medicinally-active species as well, then a single substance can provide not only the nanoscale high surface area drug delivery carrier, but the drug itself...
2016: PloS One
Haviryaji S G Kalluri, John S Kuo, Robert J Dempsey
GADD45β (Growth Arrest and DNA Damage inducible protein) is a stress activated protein which plays an important role in regulating apoptosis, proliferation, DNA repair and potentially may have a role in cancer. In this study we examined the role of anti-oxidative stress on the expression of GADD45β in glioma stem-like cells (GSC). We show that patient derived GSCs have high survival in the absence of exogenous growth factors. Addition of D609 (Tricyclodecan-9-yl-xanthogenate), a known anti-oxidative compound, to GSCs reduced the cellular ATP content with significant effects observed when GSCs were cultured in growth factor free medium...
September 20, 2016: European Journal of Pharmacology
Peter T Johannesen, Patricia Pérez-González, Sridhar Kalluri, José L Blanco, Enrique A Lopez-Poveda
The aim of this study was to assess the relative importance of cochlear mechanical dysfunction, temporal processing deficits, and age on the ability of hearing-impaired listeners to understand speech in noisy backgrounds. Sixty-eight listeners took part in the study. They were provided with linear, frequency-specific amplification to compensate for their audiometric losses, and intelligibility was assessed for speech-shaped noise (SSN) and a time-reversed two-talker masker (R2TM). Behavioral estimates of cochlear gain loss and residual compression were available from a previous study and were used as indicators of cochlear mechanical dysfunction...
2016: Trends in Hearing
T Hang Nghiem-Rao, Allison F Dahlgren, Deepti Kalluri, Yumei Cao, Pippa M Simpson, Shailendra B Patel
BACKGROUND: Premature and critically ill infants receiving total parenteral nutrition (TPN) are at risk for dyslipidemia, and altered cholesterol levels in early life may contribute to later cardiovascular risk. Data regarding plasma cholesterol response to TPN in young infants are lacking. OBJECTIVE: To determine the changes in plasma cholesterol levels during the first week of life in infants receiving TPN and a comparison group of infants who did not receive TPN during routine care...
July 2016: Journal of Clinical Lipidology
Raghu Kalluri
Among all cells, fibroblasts could be considered the cockroaches of the human body. They survive severe stress that is usually lethal to all other cells, and they are the only normal cell type that can be live-cultured from post-mortem and decaying tissue. Their resilient adaptation may reside in their intrinsic survival programmes and cellular plasticity. Cancer is associated with fibroblasts at all stages of disease progression, including metastasis, and they are a considerable component of the general host response to tissue damage caused by cancer cells...
August 23, 2016: Nature Reviews. Cancer
Sara Lovisa, Michael Zeisberg, Raghu Kalluri
Kidney fibrosis is the unavoidable consequence of chronic kidney disease irrespective of the primary underlying insult. It is a complex phenomenon governed by the interplay between different cellular components and intricate networks of signaling pathways, which together lead to loss of renal functionality and replacement of kidney parenchyma with scar tissue. An immense effort has recently been made to understand the molecular and cellular mechanisms leading to kidney fibrosis. The cellular protagonists of this process include myofibroblasts, tubular epithelial cells, endothelial cells, and immune cells...
October 2016: Trends in Endocrinology and Metabolism: TEM
Dino Samartzis, Prakasam Kalluri, Jean Herman, John P Lubicky, Francis H Shen
BACKGROUND: It has been propagated that patients with Klippel-Feil syndrome (KFS) exhibit "clinical triad" findings (CTFs), known as a short neck, low posterior hairline, and limited cervical range of motion (ROM). However, the literature has noted that up to 50 % of KFS cases may not present with such findings and the reasoning behind such assertions remains speculative. As such, the following study addressed the association between CTFs to that of congenitally-fused cervical segments and other risk factors in KFS patients...
2016: Scoliosis and Spinal Disorders
Christopher J Ryerson, Pat G Camp, Neil D Eves, Michele Schaeffer, Nafeez Syed, Satvir Dhillon, Dennis Jensen, Francois Maltais, Denis E O'Donnell, Natya Raghavan, Michael Roman, Michael K Stickland, Deborah Assayag, Jean Bourbeau, Genevieve Dion, Charlene D Fell, Nathan Hambly, Kerri A Johannson, Meena Kalluri, Nasreen Khalil, Martin Kolb, Helene Manganas, Onofre Morán-Mendoza, Steve Provencher, Warren Ramesh, J Douglass Rolf, Pearce G Wilcox, Jordan A Guenette
RATIONALE: Pulmonary rehabilitation improves dyspnea and exercise capacity in idiopathic pulmonary fibrosis (IPF); however, it is unknown whether breathing high amounts of oxygen during exercise training leads to further benefits. OBJECTIVES: Herein, we describe the design of the High Oxygen Delivery to Preserve Exercise Capacity in IPF Patients Treated with Nintedanib study (the HOPE-IPF study). The primary objective of this study is to determine the physiological and perceptual impact of breathing high levels of oxygen during exercise training in patients with IPF who are receiving antifibrotic therapy...
September 2016: Annals of the American Thoracic Society
Raja Obul Reddy Kalluri, Balakrishnaiah Gugamsetty, Rama Gopal Kotalo, Siva Kumar Reddy Nagireddy, Chakradhar Rao Tandule, Lokeswara Reddy Thotli, Reddy Rajuru Ramakrishna, Suresh Babu Surendranair
This paper describes the aerosols optical, physical characteristics and the aerosol radiative forcing pertaining to semi-arid region, Anantapur for the period January 2013-December 2014. Collocated measurements of Aerosol Optical Depth (AOD) and Black Carbon mass concentration (BC) are carried out by using MICROTOPS II and Aethalometer and estimated the aerosol radiative forcing over this location. The mean values of AOD at 500nm are found to be 0.47±0.09, 0.34±0.08, 0.29±0.06 and 0.30±0.07 during summer, winter, monsoon and post-monsoon respectively...
October 1, 2016: Science of the Total Environment
Ariel E Hight, Radha Kalluri
The vestibular nerve is characterized by two broad groups of neurons that differ in the timing of their interspike intervals; some fire at highly regular intervals, whereas others fire at highly irregular intervals. Heterogeneity in ion channel properties has been proposed as shaping these firing patterns (Highstein SM, Politoff AL. Brain Res 150: 182-187, 1978; Smith CE, Goldberg JM. Biol Cybern 54: 41-51, 1986). Kalluri et al. (J Neurophysiol 104: 2034-2051, 2010) proposed that regularity is controlled by the density of low-voltage-activated potassium currents (IKL)...
August 1, 2016: Journal of Neurophysiology
Sandra M Davern, Timothy E McKnight, Robert F Standaert, Jennifer L Morrell-Falvey, Elena D Shpak, Udaya C Kalluri, Joanna Jelenska, Jean T Greenberg, Saed Mirzadeh
Effective methods for delivering bioprobes into the cells of intact plants are essential for investigating diverse biological processes. Increasing research on trees, such as Populus spp., for bioenergy applications is driving the need for techniques that work well with tree species. This report introduces vertically aligned carbon nanofiber (VACNF) arrays as a new tool for microdelivery of labeled molecules to Populus leaf tissue and whole plants. We demonstrated that VACNFs penetrate the leaf surface to deliver sub-microliter quantities of solution containing fluorescent or radiolabeled molecules into Populus leaf cells...
2016: PloS One
Hanane Laklai, Yekaterina A Miroshnikova, Michael W Pickup, Eric A Collisson, Grace E Kim, Alex S Barrett, Ryan C Hill, Johnathon N Lakins, David D Schlaepfer, Janna K Mouw, Valerie S LeBleu, Nilotpal Roy, Sergey V Novitskiy, Julia S Johansen, Valeria Poli, Raghu Kalluri, Christine A Iacobuzio-Donahue, Laura D Wood, Matthias Hebrok, Kirk Hansen, Harold L Moses, Valerie M Weaver
Fibrosis compromises pancreatic ductal carcinoma (PDAC) treatment and contributes to patient mortality, yet antistromal therapies are controversial. We found that human PDACs with impaired epithelial transforming growth factor-β (TGF-β) signaling have high epithelial STAT3 activity and develop stiff, matricellular-enriched fibrosis associated with high epithelial tension and shorter patient survival. In several KRAS-driven mouse models, both the loss of TGF-β signaling and elevated β1-integrin mechanosignaling engaged a positive feedback loop whereby STAT3 signaling promotes tumor progression by increasing matricellular fibrosis and tissue tension...
May 2016: Nature Medicine
Raghu Kalluri
Humans circulate quadrillions of exosomes at all times. Exosomes are a class of extracellular vesicles released by all cells, with a size range of 40-150 nm and a lipid bilayer membrane. Exosomes contain DNA, RNA, and proteins. Exosomes likely remove excess and/or unnecessary constituents from the cells, functioning like garbage bags, although their precise physiological role remains unknown. Additionally, exosomes may mediate specific cell-to-cell communication and activate signaling pathways in cells they fuse or interact with...
April 1, 2016: Journal of Clinical Investigation
Yi Han, Surya Ayalasomayajula, Wei Pan, Fan Yang, Yaozong Yuan, Thomas Langenickel, Markus Hinder, Sampath Kalluri, Parasar Pal, Gangadhar Sunkara
BACKGROUND AND OBJECTIVE: Sacubitril/valsartan (LCZ696) is a first-in-class angiotensin receptor neprilysin inhibitor (ARNI) and has been recently approved in several countries for the treatment of patients with heart failure and reduced ejection fraction. This was the first study conducted to characterise the pharmacokinetics of LCZ696 analytes (pro-drug sacubitril, active neprilysin inhibitor LBQ657 and valsartan) after single-dose administration of LCZ696 in healthy Chinese subjects...
March 9, 2016: European Journal of Drug Metabolism and Pharmacokinetics
Marina Herwerth, Sudhakar Reddy Kalluri, Rajneesh Srivastava, Tatjana Kleele, Selin Kenet, Zsolt Illes, Doron Merkler, Jeffrey L Bennett, Thomas Misgeld, Bernhard Hemmer
OBJECTIVE: Neuromyelitis optica (NMO) is an autoimmune disease of the CNS, which resembles multiple sclerosis (MS). NMO differs from MS, however, in the distribution and histology of neuroinflammatory lesions and shows a more aggressive clinical course. Moreover, the majority of NMO patients carry IgG autoantibodies against aquaporin-4 (AQP4), an astrocytic water channel. Antibodies against AQP4 can damage astrocytes via complement, but NMO histopathology also shows demyelination, and - importantly - axon injury, which may determine permanent deficits following NMO relapses...
March 6, 2016: Annals of Neurology
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