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https://www.readbyqxmd.com/read/28936513/solar-cells-with-pbs-quantum-dot-sensitized-tio2-multiwalled-carbon-nanotube-composites-sulfide-titania-gel-and-tin-sulfide-coated-c-fabric
#1
Ramesh K Kokal, Melepurath Deepa, Ankarao Kalluri, Shrishti Singh, Isaac Macwan, Prabir K Patra, Jeff Gilarde
Novel approaches to boost quantum dot solar cell (QDSC) efficiencies are in demand. Herein, three strategies are used: (i) a hydrothermally synthesized TiO2-multiwalled carbon nanotube (MWCNT) composite instead of conventional TiO2, (ii) a counter electrode (CE) that has not been applied to QDSCs until now, namely, tin sulfide (SnS) nanoparticles (NPs) coated over a conductive carbon (C)-fabric, and (iii) a quasi-solid-state gel electrolyte composed of S(2-), an inert polymer and TiO2 nanoparticles as opposed to a polysulfide solution based hole transport layer...
October 4, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28929903/predictors-of-hearing-aid-outcomes
#2
Enrique A Lopez-Poveda, Peter T Johannesen, Patricia Pérez-González, José L Blanco, Sridhar Kalluri, Brent Edwards
Over 360 million people worldwide suffer from disabling hearing loss. Most of them can be treated with hearing aids. Unfortunately, performance with hearing aids and the benefit obtained from using them vary widely across users. Here, we investigate the reasons for such variability. Sixty-eight hearing-aid users or candidates were fitted bilaterally with nonlinear hearing aids using standard procedures. Treatment outcome was assessed by measuring aided speech intelligibility in a time-reversed two-talker background and self-reported improvement in hearing ability...
January 2017: Trends in Hearing
https://www.readbyqxmd.com/read/28921953/new-antimony-selenide-nickel-oxide-photocathode-boosts-the-efficiency-of-graphene-quantum-dot-co-sensitized-solar-cells
#3
Ankita Kolay, Ramesh K Kokal, Ankarao Kalluri, Isaac Macwan, Prabir K Patra, Partha Ghosal, Melepurath Deepa
A novel assembly of a photocathode and a photoanode is investigated to explore their complementary effects in enhancing the photovoltaic performance of a quantum-dot solar cell (QDSC). While p-type nickel oxide (NiO) has been used previously, antimony selenide (Sb2Se3) has not been used in a QDSC, especially as a component of a counter electrode (CE) architecture that doubles as the photocathode. Here, near-infrared (NIR) light-absorbing Sb2Se3 nanoparticles (NPs) coated over electrodeposited NiO nanofibers on a carbon (C) fabric substrate was employed as the highly efficient photocathode...
October 11, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28863614/towards-a-joint-reflection-distortion-otoacoustic-emission-profile-results-in-normal-and-impaired-ears
#4
Carolina Abdala, Radha Kalluri
Otoacoustic emissions (OAEs) provide salient information about cochlear function and dysfunction. Two broad classes of emissions, linear reflection and nonlinear distortion, arise via distinct cochlear processes and hence, appear to provide independent information about cochlear health and hearing. Considered in combination, these two OAE types may characterize sensory hearing loss most effectively. In this study, the level-dependent growth of stimulus-frequency OAEs (a reflection-type emission) and distortion-product OAEs (a distortion-type emission) were measured in ten normal-hearing ears and eight ears with slight-to-moderate sensorineural hearing loss...
August 2017: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/28855213/exosomes-from-glioma-associated-mesenchymal-stem-cells-increase-the-tumorigenicity-of-glioma-stem-like-cells-via-transfer-of-mir-1587
#5
Javier Figueroa, Lynette M Phillips, Tal Shahar, Anwar Hossain, Joy Gumin, Hoon Kim, Andrew J Bean, George A Calin, Juan Fueyo, Edgar T Walters, Raghu Kalluri, Roel G Verhaak, Frederick F Lang
Tumor-stromal communications impact tumorigenesis in ways that are incompletely understood. Here we show that Glioma Associated-human Mesenchymal Stem Cells (GA-hMSCs), a newly identified stromal component of glioblastoma, release exosomes that increase the proliferation and clonogenicity of tumor-initiating Glioma Stem-like Cells (GSCs). This event leads to a significantly greater tumor burden and decreased host survival compared with untreated GSCs in orthotopic xenografts. Analysis of the exosomal content identified miR-1587 as a mediator of the exosomal effects on GSCs, in part via down-regulation of the tumor suppressive nuclear receptor co-repressor NCOR1...
August 30, 2017: Cancer Research
https://www.readbyqxmd.com/read/28802717/chronic-d609-treatment-interferes-with-cell-cycle-and-targets-the-expression-of-olig2-in-glioma-stem-like-cells
#6
Haviryaji S G Kalluri, John S Kuo, Robert J Dempsey
Glioma Stem-like Cells (GSCs) isolated from patient derived tumors have high metabolic activity and survive in the absence of exogenous growth factors. We recently demonstrated that acute D609 (Tricyclodecan-9-yl-xanthogenate), a PC-PLC inhibitor with anti-oxidative property, can decrease the ATP content & GADD45β protein in GSCs cultured without growth factors, but not in the presence of growth factors. In this study we examined the effect of chronic D609 treatment on GSCs cultured in complete medium containing growth factors...
November 5, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28775207/development-of-aggressive-pancreatic-ductal-adenocarcinomas-depends-on-granulocyte-colony-stimulating-factor-secretion-in-carcinoma-cells
#7
Michael W Pickup, Philip Owens, Agnieszka E Gorska, Anna Chytil, Fei Ye, Chanjuan Shi, Valerie M Weaver, Raghu Kalluri, Harold L Moses, Sergey V Novitskiy
The survival rate for pancreatic ductal adenocarcinoma (PDAC) remains low. More therapeutic options to treat this disease are needed, for the current standard of care is ineffective. Using an animal model of aggressive PDAC (Kras/p48(TGFβRIIKO)), we discovered an effect of TGFβ signaling in regulation of G-CSF secretion in pancreatic epithelium. Elevated concentrations of G-CSF in PDAC promoted differentiation of Ly6G(+) cells from progenitors, stimulated IL10 secretion from myeloid cells, and decreased T-cell proliferation via upregulation of Arg, iNOS, VEGF, IL6, and IL1b from CD11b(+) cells...
September 2017: Cancer Immunology Research
https://www.readbyqxmd.com/read/28720851/microneedle-patch-delivery-of-influenza-vaccine-during-pregnancy-enhances-maternal-immune-responses-promoting-survival-and-long-lasting-passive-immunity-to-offspring
#8
E Stein Esser, Joanna A Pulit-Penaloza, Haripriya Kalluri, Devin McAllister, Elena V Vassilieva, Elizabeth Q Littauer, Nadia Lelutiu, Mark R Prausnitz, Richard W Compans, Ioanna Skountzou
Influenza virus causes life-threatening infections in pregnant women and their newborns. Immunization during pregnancy is the most effective means of preventing maternal and infant mortality/morbidity; however, influenza vaccination rates of pregnant women remain under 50%. Furthermore, the availability of vaccines in low-resource populations is limited. Skin immunization with microneedle patches (MN) is a novel and safe vaccination platform featuring thermostable vaccine formulations. Cold-chain independence and the potential for self-administration can expand influenza vaccination coverage in developing countries...
July 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28688108/a-physiologically-based-pharmacokinetic-modelling-approach-to-predict-buprenorphine-pharmacokinetics-following-intravenous-and-sublingual-administration
#9
Hari V Kalluri, Hongfei Zhang, Steve N Caritis, Raman Venkataramanan
AIMS: Opioid dependence is associated with high morbidity and mortality. Buprenorphine (BUP) is approved by the Food and Drug Administration to treat opioid dependence. There is a lack of clear consensus on the appropriate dosing of BUP due to interpatient physiological differences in absorption/disposition, subjective response assessment and other patient comorbidities. The objective of the present study was to build and validate robust physiologically based pharmacokinetic (PBPK) models for intravenous (IV) and sublingual (SL) BUP as a first step to optimizing BUP pharmacotherapy...
July 8, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28669739/an-evidence-based-recommendation-to-increase-the-dosing-frequency-of-buprenorphine-during-pregnancy
#10
Steve N Caritis, Jaime R Bastian, Hongfei Zhang, Hari Kalluri, Dennis English, Michael England, Stephanie Bobby, Raman Venkataramanan
BACKGROUND: Dose-adjusted plasma concentrations of buprenorphine are significantly decreased during pregnancy compared with the nonpregnant state. This observation suggests that pregnant women may need a higher dose of buprenorphine than nonpregnant individuals to maintain similar drug exposure (plasma concentrations over time after a dose). The current dosing recommendations for buprenorphine during pregnancy address the total daily dose of buprenorphine to be administered, but the frequency of dosing is not clearly addressed...
October 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28666680/the-safety-immunogenicity-and-acceptability-of-inactivated-influenza-vaccine-delivered-by-microneedle-patch-tiv-mnp-2015-a-randomised-partly-blinded-placebo-controlled-phase-1-trial
#11
Nadine G Rouphael, Michele Paine, Regina Mosley, Sebastien Henry, Devin V McAllister, Haripriya Kalluri, Winston Pewin, Paula M Frew, Tianwei Yu, Natalie J Thornburg, Sarah Kabbani, Lilin Lai, Elena V Vassilieva, Ioanna Skountzou, Richard W Compans, Mark J Mulligan, Mark R Prausnitz
BACKGROUND: Microneedle patches provide an alternative to conventional needle-and-syringe immunisation, and potentially offer improved immunogenicity, simplicity, cost-effectiveness, acceptability, and safety. We describe safety, immunogenicity, and acceptability of the first-in-man study on single, dissolvable microneedle patch vaccination against influenza. METHODS: The TIV-MNP 2015 study was a randomised, partly blinded, placebo-controlled, phase 1, clinical trial at Emory University that enrolled non-pregnant, immunocompetent adults from Atlanta, GA, USA, who were aged 18-49 years, naive to the 2014-15 influenza vaccine, and did not have any significant dermatological disorders...
August 12, 2017: Lancet
https://www.readbyqxmd.com/read/28644693/supplemental-oxygen-in-interstitial-lung-disease-an-art-in-need-of-science
#12
Kerri A Johannson, Sachin R Pendharkar, Kirk Mathison, Charlene D Fell, Jordan A Guenette, Meena Kalluri, Martin Kolb, Christopher J Ryerson
Interstitial lung disease (ILD) comprises a large and heterogeneous group of disorders that often lead to progressive fibrosis and premature death. Oxygen supplementation is typically used in patients with advanced lung disease with resting hypoxemia; however, there is a paucity of evidence guiding the use of supplemental oxygen in ILD, and significant heterogeneity in clinical practice. It remains unclear whether supplemental oxygen improves clinically meaningful outcomes, and the role of ambulatory oxygen supplementation in isolated exertional hypoxemia is particularly controversial...
September 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28630183/bioavailability-of-lumefantrine-is-significantly-enhanced-with-a-novel-formulation-approach-an-outcome-from-a-randomized-open-label-pharmacokinetic-study-in-healthy-volunteers
#13
Jay Prakash Jain, F Joel Leong, Lan Chen, Sampath Kalluri, Vishal Koradia, Daniel S Stein, Marie-Christine Wolf, Gangadhar Sunkara, Jagannath Kota
The artemether-lumefantrine combination requires food intake for the optimal absorption of lumefantrine. In an attempt to enhance the bioavailability of lumefantrine, new solid dispersion formulations (SDF) were developed, and the pharmacokinetics of two SDF variants were assessed in a randomized, open-label, sequential two-part study in healthy volunteers. In part 1, the relative bioavailability of the two SDF variants was compared with that of the conventional formulation after administration of a single dose of 480 mg under fasted conditions in three parallel cohorts...
September 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28607485/exosomes-facilitate-therapeutic-targeting-of-oncogenic-kras-in-pancreatic-cancer
#14
Sushrut Kamerkar, Valerie S LeBleu, Hikaru Sugimoto, Sujuan Yang, Carolina F Ruivo, Sonia A Melo, J Jack Lee, Raghu Kalluri
The mutant form of the GTPase KRAS is a key driver of pancreatic cancer but remains a challenging therapeutic target. Exosomes are extracellular vesicles generated by all cells, and are naturally present in the blood. Here we show that enhanced retention of exosomes, compared to liposomes, in the circulation of mice is likely due to CD47-mediated protection of exosomes from phagocytosis by monocytes and macrophages. Exosomes derived from normal fibroblast-like mesenchymal cells were engineered to carry short interfering RNA or short hairpin RNA specific to oncogenic Kras(G12D), a common mutation in pancreatic cancer...
June 22, 2017: Nature
https://www.readbyqxmd.com/read/28524195/enhanced-reactivity-and-selectivity-of-asymmetric-oxa-michael-addition-of-2-hydroxychalcones-in-carbon-confined-spaces
#15
Melad Shaikh, Kiran Kumar Atyam, Mahendra Sahu, Kalluri V S Ranganath
Carbon nanotubes (CNTs) are employed as nanoscale reaction vessels for the asymmetric oxa-Michael addition of 2'-hydroxychalcones. A systematic comparison of the catalytic activities of chiral phosphoric acid treated ferrite nanoparticles (chiral ferrites) has been studied for the synthesis of flavanones. Higher reactivity and selectivity with switching of enantiomers were observed when these chiral ferrites are inside the CNT channel.
May 19, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28524163/an-evolving-function-of-dna-containing-exosomes-in-chemotherapy-induced-immune-response
#16
Paul Kurywchak, Raghu Kalluri
Chemotherapy is a predominant strategy to treat cancer and is often associated with toxicities like severe diarrhea that puts patients at additional risk and can hinder treatment strategies. Lian et al. recently explored the immune-mediated mechanisms of Irinotecan-induced diarrhea in colorectal cancer and found that double-stranded DNA in small vesicles can launch inflammation pathways in immune cells through the cytosolic DNA sensor AIM2.
June 2017: Cell Research
https://www.readbyqxmd.com/read/28497058/impact-of-an-intensive-perinatal-handwashing-promotion-intervention-on-maternal-handwashing-behavior-in-the-neonatal-period-findings-from-a-randomized-controlled-trial-in-rural-bangladesh
#17
Pavani Kalluri Ram, Sharifa Nasreen, Kelly Kamm, Jelena Allen, Swapna Kumar, Mohammad Anisur Rahman, K Zaman, Shams El Arifeen, Stephen P Luby
One-quarter of neonatal deaths are attributed to infections. Maternal handwashing with soap may prevent neonatal sepsis. We examined impact of intensive handwashing promotion on handwashing behavior of mothers of neonates. In Matlab, Bangladesh, we randomly allocated pregnant women at 28-32 weeks' gestation to intensive handwashing promotion or control. Behavior change communicators used a participatory approach to motivate maternal handwashing with soap and provided soap and handwashing stations. In the neonatal period, we observed soap and water at handwashing places and, at the end of the neonatal period, we estimated impact on maternal handwashing by structured observation...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28447602/spatial-computation-of-intratumoral-t-cells-correlates-with-survival-of-patients-with-pancreatic-cancer
#18
Julienne L Carstens, Pedro Correa de Sampaio, Dalu Yang, Souptik Barua, Huamin Wang, Arvind Rao, James P Allison, Valerie S LeBleu, Raghu Kalluri
The exact nature and dynamics of pancreatic ductal adenocarcinoma (PDAC) immune composition remains largely unknown. Desmoplasia is suggested to polarize PDAC immunity. Therefore, a comprehensive evaluation of the composition and distribution of desmoplastic elements and T-cell infiltration is necessary to delineate their roles. Here we develop a novel computational imaging technology for the simultaneous evaluation of eight distinct markers, allowing for spatial analysis of distinct populations within the same section...
April 27, 2017: Nature Communications
https://www.readbyqxmd.com/read/28424339/discovery-of-double-stranded-genomic-dna-in-circulating-exosomes
#19
Raghu Kalluri, Valerie S LeBleu
It is becoming increasingly clear that small vesicles released from cells (extracellular vesicles [EVs]) represent a heterogeneous population implicated in cell-to-cell communication. The classifications and nomenclature of EVs are evolving as enrichment strategies and specific characteristics are being unraveled. At present, physical properties of EVs-namely, size, shape, and density-are often used to identify subpopulations of EVs. A distinct group of EVs, termed exosomes, largely defined by their small size (∼40-150 nm) and proposed subcellular origin, has been extensively studied in several aspects of cancer biology...
2016: Cold Spring Harbor Symposia on Quantitative Biology
https://www.readbyqxmd.com/read/28424335/a-conversation-with-raghu-kalluri
#20
(no author information available yet)
No abstract text is available yet for this article.
April 19, 2017: Cold Spring Harbor Symposia on Quantitative Biology
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