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https://www.readbyqxmd.com/read/28122799/cystic-lymphangioma-of-spleen-in-adults
#1
Shalini Duvvada, Debadutta Senapati, Sreenivas Rao Challa, Tejokrishna Kalluri
Splenic diseases are rare. Tumours of the spleen are classified as either benign or malignant. Primary benign tumours of the spleen are extremely rare, identified on surgery and autopsy, accounting for <0.007% of all splenic tumours. Splenic lymphangiomas are benign cystic tumours resulting from congenital malformations of the lymphatic system that appear as a single or multiple lesions of the spleen. It mainly affects children and is rarely manifested after the age of 20 years of age. We report a case of cystic lymphangioma of spleen in a 40-year-old woman admitted with a huge mass in the abdomen, which on imaging found to be a cystic mass arising from spleen...
January 25, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28121262/detection-of-mutant-kras-and-tp53-dna-in-circulating-exosomes-from-healthy-individuals-and-patients-with-pancreatic-cancer
#2
Sujuan Yang, Sara P Y Che, Paul Kurywchak, Jena L Tavormina, Liv B Gansmo, Pedro Correa de Sampaio, Michael Tachezy, Maximilian Bockhorn, Florian Gebauer, Amanda R Haltom, Sonia A Melo, Valerie S LeBleu, Raghu Kalluri
Pancreatic cancer presents with a dismal mortality rate and is in urgent need of methods for early detection with potential for timely intervention. All living cells, including cancer cells, generate exosomes. We previously discovered double stranded genomic DNA in exosomes derived from the circulation of pancreatic cancer patients, which enabled the detection of prevalent mutations associated with the disease. Here, we report a proof-of-concept study that demonstrates the potential clinical utility of circulating exosomal DNA for identification of KRAS(G)(12)(D) and TP53(R)(273)(H) mutations in patients with pancreas-associated pathologies, including pancreatic ductal adenocarcinoma (PDAC), chronic pancreatitis (CP) and intraductal papillary mucinous neoplasm (IPMN), and in healthy human subjects...
January 25, 2017: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/28063858/early-and-integrated-palliative-care-to-achieve-a-home-death-in-idiopathic-pulmonary-fibrosis
#3
Meena Kalluri, Janice Richman-Eisenstat
No abstract text is available yet for this article.
January 4, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/28058717/deletional-tolerance-prevents-aqp4-directed-autoimmunity-in-mice
#4
Anna-Lena Vogel, Benjamin Knier, Katja Lammens, Sudhakar Reddy Kalluri, Tanja Kuhlmann, Jeffrey L Bennett, Thomas Korn
Neuromyelitis optica (NMO) is an autoimmune disorder of the central nervous system (CNS) mediated by antibodies to the water channel protein AQP4 expressed in astrocytes. The contribution of AQP4-specific T cells to the class switch recombination of pathogenic AQP4-specific antibodies and the inflammation of the blood-brain barrier is incompletely understood, as immunogenic naturally processed T-cell epitopes of AQP4 are unknown. By immunizing Aqp4(-/-) mice with full-length murine AQP4 protein followed by recall with overlapping peptides, we here identify AQP4(201-220) as the major immunogenic IA(b) -restricted epitope of AQP4...
January 5, 2017: European Journal of Immunology
https://www.readbyqxmd.com/read/27871261/quantitative-characterization-of-t-cell-repertoire-and-biomarkers-in-kidney-transplant-rejection
#5
Houda Alachkar, Martin Mutonga, Taigo Kato, Sowjanya Kalluri, Yoichi Kakuta, Motohide Uemura, Ryoichi Imamura, Norio Nonomura, Vikas Vujjini, Sami Alasfar, Hamid Rabb, Yusuke Nakamura, Nada Alachkar
BACKGROUND: T-cell-mediated rejection (TCMR) remains a major cause of kidney allograft failure. The characterization of T-cell repertoire in different immunological disorders has emerged recently as a novel tool with significant implications. We herein sought to characterize T-cell repertoire using next generation sequencing to diagnose TCMR. METHODS: In this prospective study, we analyzed samples from 50 kidney transplant recipients. We collected blood and kidney transplant biopsy samples at sequential time points before and post transplant...
November 21, 2016: BMC Nephrology
https://www.readbyqxmd.com/read/27850524/886-altered-acyclovir-pharmacokinetics-a-physiologically-based-pharmacokinetic-approach
#6
Joseph Durkin, Hari Kalluri
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27758153/development-and-evaluation-of-a-mixed-gender-multi-talker-matrix-sentence-test-in-australian-english
#7
Heather Kelly, Gaven Lin, Narayan Sankaran, Jing Xia, Sridhar Kalluri, Simon Carlile
OBJECTIVE: To develop, in Australian English, the first mixed-gender, multi-talker matrix sentence test. DESIGN: Speech material consisted of a 50-word base matrix whose elements can be combined to form sentences of identical syntax but unpredictable content. Ten voices (five female and five male) were recorded for editing and preliminary level equalization. Elements were presented as single-talker sentences-in-noise during two perceptual tests: an optimization phase that provided the basis for further level correction, and an evaluation phase that perceptually validated those changes...
October 19, 2016: International Journal of Audiology
https://www.readbyqxmd.com/read/27757116/down-regulation-of-korrigan-like-endo-%C3%AE-1-4-glucanase-genes-impacts-carbon-partitioning-mycorrhizal-colonization-and-biomass-production-in-populus
#8
Udaya C Kalluri, Raja S Payyavula, Jessy L Labbé, Nancy Engle, Garima Bali, Sara S Jawdy, Robert W Sykes, Mark Davis, Arthur Ragauskas, Gerald A Tuskan, Timothy J Tschaplinski
A greater understanding of the genetic regulation of plant cell wall remodeling and the impact of modified cell walls on plant performance is important for the development of sustainable biofuel crops. Here, we studied the impact of down-regulating KORRIGAN-like cell wall biosynthesis genes, belonging to the endo-β-1,4-glucanase gene family, on Populus growth, metabolism and the ability to interact with symbiotic microbes. The reductions in cellulose content and lignin syringyl-to-guaiacyl unit ratio, and increase in cellulose crystallinity of cell walls of PdKOR RNAi plants corroborated the functional role of PdKOR in cell wall biosynthesis...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27728216/didmoad-syndrome
#9
Kalluri Chinna Rao, M Madhusudhan Babu
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27728192/a-study-of-association-of-subclinical-hypothyroidism-and-diabetic-retinopathy-in-diabetic-patients
#10
Kalluri Chinna Rao, M Madhusudhana Babu
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27692563/low-dose-hydralazine-prevents-fibrosis-in-a-murine-model-of-acute-kidney-injury-to-chronic-kidney-disease-progression
#11
Björn Tampe, Ulrike Steinle, Désirée Tampe, Julienne L Carstens, Peter Korsten, Elisabeth M Zeisberg, Gerhard A Müller, Raghu Kalluri, Michael Zeisberg
Acute kidney injury (AKI) and progressive chronic kidney disease (CKD) are intrinsically tied syndromes. In this regard, the acutely injured kidney often does not achieve its full regenerative capacity and AKI directly transitions into progressive CKD associated with tubulointerstitial fibrosis. Underlying mechanisms of such AKI-to-CKD progression are still incompletely understood and specific therapeutic interventions are still elusive. Because epigenetic modifications play a role in maintaining tissue fibrosis, we used a murine model of ischemia-reperfusion injury to determine whether aberrant promoter methylation of RASAL1 contributes causally to the switch between physiological regeneration and tubulointerstitial fibrogenesis, a hallmark of AKI-to-CKD progression...
January 2017: Kidney International
https://www.readbyqxmd.com/read/27684478/single-plant-derived-nanotechnology-for-synergistic-antibacterial-therapies
#12
Jhansi R Kalluri, Roberto Gonzalez-Rodriguez, Phil S Hartman, Armando Loni, Leigh T Canham, Jeffery L Coffer
Multiple new approaches to tackle multidrug resistant infections are urgently needed and under evaluation. One nanotechnology-based approach to delivering new relevant therapeutics involves silicon accumulator plants serving as a viable silicon source in green routes for the fabrication of the nanoscale drug delivery carrier porous silicon (pSi). If the selected plant leaf components contain medicinally-active species as well, then a single substance can provide not only the nanoscale high surface area drug delivery carrier, but the drug itself...
2016: PloS One
https://www.readbyqxmd.com/read/27658347/effect-of-d609-on-the-expression-of-gadd45%C3%AE-protein-potential-inhibitory-role-in-the-growth-of-glioblastoma-cancer-stem-like-cells
#13
Haviryaji S G Kalluri, John S Kuo, Robert J Dempsey
GADD45β (Growth Arrest and DNA Damage inducible protein) is a stress activated protein which plays an important role in regulating apoptosis, proliferation, DNA repair and potentially may have a role in cancer. In this study we examined the role of anti-oxidative stress on the expression of GADD45β in glioma stem-like cells (GSC). We show that patient derived GSCs have high survival in the absence of exogenous growth factors. Addition of D609 (Tricyclodecan-9-yl-xanthogenate), a known anti-oxidative compound, to GSCs reduced the cellular ATP content with significant effects observed when GSCs were cultured in growth factor free medium...
November 15, 2016: European Journal of Pharmacology
https://www.readbyqxmd.com/read/27604779/the-influence-of-cochlear-mechanical-dysfunction-temporal-processing-deficits-and-age-on-the-intelligibility-of-audible-speech-in-noise-for-hearing-impaired-listeners
#14
Peter T Johannesen, Patricia Pérez-González, Sridhar Kalluri, José L Blanco, Enrique A Lopez-Poveda
The aim of this study was to assess the relative importance of cochlear mechanical dysfunction, temporal processing deficits, and age on the ability of hearing-impaired listeners to understand speech in noisy backgrounds. Sixty-eight listeners took part in the study. They were provided with linear, frequency-specific amplification to compensate for their audiometric losses, and intelligibility was assessed for speech-shaped noise (SSN) and a time-reversed two-talker masker (R2TM). Behavioral estimates of cochlear gain loss and residual compression were available from a previous study and were used as indicators of cochlear mechanical dysfunction...
2016: Trends in Hearing
https://www.readbyqxmd.com/read/27578120/influence-of-gestational-age-and-birth-weight-in%C3%A2-neonatal-cholesterol-response-to-total-parenteral-nutrition
#15
T Hang Nghiem-Rao, Allison F Dahlgren, Deepti Kalluri, Yumei Cao, Pippa M Simpson, Shailendra B Patel
BACKGROUND: Premature and critically ill infants receiving total parenteral nutrition (TPN) are at risk for dyslipidemia, and altered cholesterol levels in early life may contribute to later cardiovascular risk. Data regarding plasma cholesterol response to TPN in young infants are lacking. OBJECTIVE: To determine the changes in plasma cholesterol levels during the first week of life in infants receiving TPN and a comparison group of infants who did not receive TPN during routine care...
July 2016: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/27550820/the-biology-and-function-of-fibroblasts-in-cancer
#16
Raghu Kalluri
Among all cells, fibroblasts could be considered the cockroaches of the human body. They survive severe stress that is usually lethal to all other cells, and they are the only normal cell type that can be live-cultured from post-mortem and decaying tissue. Their resilient adaptation may reside in their intrinsic survival programmes and cellular plasticity. Cancer is associated with fibroblasts at all stages of disease progression, including metastasis, and they are a considerable component of the general host response to tissue damage caused by cancer cells...
August 23, 2016: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/27372267/partial-epithelial-to-mesenchymal-transition-and-other-new-mechanisms-of-kidney-fibrosis
#17
REVIEW
Sara Lovisa, Michael Zeisberg, Raghu Kalluri
Kidney fibrosis is the unavoidable consequence of chronic kidney disease irrespective of the primary underlying insult. It is a complex phenomenon governed by the interplay between different cellular components and intricate networks of signaling pathways, which together lead to loss of renal functionality and replacement of kidney parenchyma with scar tissue. An immense effort has recently been made to understand the molecular and cellular mechanisms leading to kidney fibrosis. The cellular protagonists of this process include myofibroblasts, tubular epithelial cells, endothelial cells, and immune cells...
October 2016: Trends in Endocrinology and Metabolism: TEM
https://www.readbyqxmd.com/read/27355085/-clinical-triad-findings-in-pediatric-klippel-feil-patients
#18
Dino Samartzis, Prakasam Kalluri, Jean Herman, John P Lubicky, Francis H Shen
BACKGROUND: It has been propagated that patients with Klippel-Feil syndrome (KFS) exhibit "clinical triad" findings (CTFs), known as a short neck, low posterior hairline, and limited cervical range of motion (ROM). However, the literature has noted that up to 50 % of KFS cases may not present with such findings and the reasoning behind such assertions remains speculative. As such, the following study addressed the association between CTFs to that of congenitally-fused cervical segments and other risk factors in KFS patients...
2016: Scoliosis and Spinal Disorders
https://www.readbyqxmd.com/read/27348402/high-oxygen-delivery-to-preserve-exercise-capacity-in-patients-with-idiopathic-pulmonary-fibrosis-treated-with-nintedanib-methodology-of-the-hope-ipf-study
#19
Christopher J Ryerson, Pat G Camp, Neil D Eves, Michele Schaeffer, Nafeez Syed, Satvir Dhillon, Dennis Jensen, Francois Maltais, Denis E O'Donnell, Natya Raghavan, Michael Roman, Michael K Stickland, Deborah Assayag, Jean Bourbeau, Genevieve Dion, Charlene D Fell, Nathan Hambly, Kerri A Johannson, Meena Kalluri, Nasreen Khalil, Martin Kolb, Helene Manganas, Onofre Morán-Mendoza, Steve Provencher, Warren Ramesh, J Douglass Rolf, Pearce G Wilcox, Jordan A Guenette
RATIONALE: Pulmonary rehabilitation improves dyspnea and exercise capacity in idiopathic pulmonary fibrosis (IPF); however, it is unknown whether breathing high amounts of oxygen during exercise training leads to further benefits. OBJECTIVES: Herein, we describe the design of the High Oxygen Delivery to Preserve Exercise Capacity in IPF Patients Treated with Nintedanib study (the HOPE-IPF study). The primary objective of this study is to determine the physiological and perceptual impact of breathing high levels of oxygen during exercise training in patients with IPF who are receiving antifibrotic therapy...
September 2016: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/27344510/direct-radiative-forcing-properties-of-atmospheric-aerosols-over-semi-arid-region-anantapur-in-india
#20
Raja Obul Reddy Kalluri, Balakrishnaiah Gugamsetty, Rama Gopal Kotalo, Siva Kumar Reddy Nagireddy, Chakradhar Rao Tandule, Lokeswara Reddy Thotli, Reddy Rajuru Ramakrishna, Suresh Babu Surendranair
This paper describes the aerosols optical, physical characteristics and the aerosol radiative forcing pertaining to semi-arid region, Anantapur for the period January 2013-December 2014. Collocated measurements of Aerosol Optical Depth (AOD) and Black Carbon mass concentration (BC) are carried out by using MICROTOPS II and Aethalometer and estimated the aerosol radiative forcing over this location. The mean values of AOD at 500nm are found to be 0.47±0.09, 0.34±0.08, 0.29±0.06 and 0.30±0.07 during summer, winter, monsoon and post-monsoon respectively...
October 1, 2016: Science of the Total Environment
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