keyword
https://read.qxmd.com/read/38529947/a-novel-machine-learning-algorithm-selects-proteome-signature-to-specifically-identify-cancer-exosomes
#1
JOURNAL ARTICLE
Bingrui Li, Fernanda G Kugeratski, Raghu Kalluri
Non-invasive early cancer diagnosis remains challenging due to the low sensitivity and specificity of current diagnostic approaches. Exosomes are membrane-bound nanovesicles secreted by all cells that contain DNA, RNA, and proteins that are representative of the parent cells. This property, along with the abundance of exosomes in biological fluids makes them compelling candidates as biomarkers. However, a rapid and flexible exosome-based diagnostic method to distinguish human cancers across cancer types in diverse biological fluids is yet to be defined...
March 26, 2024: ELife
https://read.qxmd.com/read/38520780/patient-outcomes-and-complications-following-various-maxillomandibular-fixation-techniques-a-systematic-review-and-meta-analysis
#2
REVIEW
Manasa H Kalluri, Armin Edalatpour, Kishan M Thadikonda, Jessica D Blum, Catharine B Garland, Daniel Y Cho
PURPOSE: Currently, there are several methods of achieving maxillomandibular fixation (MMF), each with its unique operative considerations and subsequent patient outcomes and complications. In this study, we reviewed the literature to evaluate and compare all MMF methods. METHODS: A systematic review of all MMF types was conducted and post-operative outcome data were analyzed and compared among the different types. Conventional Erich arch bars were compared to hybrid arch bars, MMF screws, and eyelet interdental wiring...
March 6, 2024: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://read.qxmd.com/read/38483172/preoperative-opioid-use-and-postoperative-outcomes-in-patients-undergoing-microvascular-decompression-for-trigeminal-neuralgia
#3
JOURNAL ARTICLE
Anita L Kalluri, Emeka Ejimogu, Collin Kilgore, Sumil K Nair, Kathleen R Ran, Mostafa Abdulrahim, Michael E Xie, Kyra Halbert-Elliott, Vivek Yedavalli, Michael Lim, Christopher M Jackson, Judy Huang, Chetan Bettegowda, Risheng Xu
BACKGROUND AND OBJECTIVES: The prescription of opioid analgesics for trigeminal neuralgia (TN) is controversial, and their effect on postoperative outcomes for patients with TN undergoing microvascular decompression (MVD) has not been reported. We aimed to describe the relationship between preoperative opioid use and postoperative outcomes in patients with TN undergoing MVD. METHODS: We reviewed the records of 920 patients with TN at our institution who underwent an MVD between 2007 and 2020...
March 14, 2024: Neurosurgery
https://read.qxmd.com/read/38454844/prevalence-of-blindness-and-visual-impairment-in-a-coastal-region-of-southern-india-a-cross-sectional-survey-in-prakasam-district-andhra-pradesh
#4
JOURNAL ARTICLE
Hemanth Kumar, Hira Pant, Sirshendu Chaudhuri, Viswanath Kalluri, Vijay Kiran Sarvepally, Vishal Govindahari, Praveen Vashist, Radhika Tandon, Gvs Murthy
PURPOSE: To estimate the magnitude, determinants, and causes of visual impairment (VI) and blindness among people >40 years. METHODS: In this cross-sectional survey, 2,968 people >40 years from 34 clusters were examined. A cluster random sampling method with a compact segment sampling technique was used to select the study participants. Prevalence of any VI (presenting visual acuity (PVA) <6/12 in better eye), severe VI (PVA <6/60 - 3/60), and blindness (PVA <3/60 in better eye) were expressed as percentage with 95% confidence interval...
March 8, 2024: Indian Journal of Ophthalmology
https://read.qxmd.com/read/38401993/preparation-and-optimization-of-an-eggshell-membrane-based-biomaterial-for-gtr-applications
#5
JOURNAL ARTICLE
Lohitha Kalluri, Jason A Griggs, Amol V Janorkar, Xiaoming Xu, Ravi Chandran, Hao Mei, Kadie P Nobles, Shan Yang, Laura Alberto, Yuanyuan Duan
OBJECTIVES: Guided Tissue Regeneration (GTR) is a popular clinical procedure for periodontal tissue regeneration. However, its key component, the barrier membrane, is largely collagen-based and is still quite expensive, posing a financial burden to the patients as well as healthcare systems and negatively impacting the patient's decision-making. Thus, our aim is to prepare a novel biomimetic GTR membrane utilizing a natural biomaterial, soluble eggshell membrane protein (SEP), which is economical as it comes from an abundant industrial waste from food and poultry industries, unlike collagen...
February 23, 2024: Dental Materials
https://read.qxmd.com/read/38389387/bioequivalence-between-a-new-omalizumab-prefilled-syringe-with-an-autoinjector-or-with-a-needle-safety-device-compared-with-the-current-prefilled-syringe-a-randomized-controlled-trial-in-healthy-volunteers
#6
JOURNAL ARTICLE
Ramachandra Sangana, Yan Xu, Bharti Shah, Xianbin Tian, Julia Zack, Kasra Shakeri-Nejad, Sampath Kalluri, Ieuan Jones, Monica Ligueros-Saylan, Angel Fowler Taylor, Devendra Kumar Jain, Emil Scosyrev, Alkaz Uddin, Nathalie Laurent, Paola Paganoni
Omalizumab is an anti-IgE monoclonal antibody currently approved for the treatment of asthma, nasal polyps/chronic rhinosinusitis with nasal polyps, and chronic spontaneous urticaria. Omalizumab is available as an injection in a prefilled syringe (PFS) with a needle safety device (NSD). New product configurations were developed to reduce the number of injections per dose administration, improve patient convenience and treatment compliance. The objective of this randomized open-label 12-week study was to demonstrate pharmacokinetic bioequivalence between (1) new PFS with autoinjector (PFS-AI), (2) new PFS-NSD configuration, and (3) current PFS-NSD configuration...
February 22, 2024: Clinical Pharmacology in Drug Development
https://read.qxmd.com/read/38383779/b-cells-orchestrate-tolerance-to-the-neuromyelitis-optica-autoantigen-aqp4
#7
JOURNAL ARTICLE
Ali Maisam Afzali, Lucy Nirschl, Christopher Sie, Monika Pfaller, Oleksii Ulianov, Tobias Hassler, Christine Federle, Elisabetta Petrozziello, Sudhakar Reddy Kalluri, Hsin Hsiang Chen, Sofia Tyystjärvi, Andreas Muschaweckh, Katja Lammens, Claire Delbridge, Andreas Büttner, Katja Steiger, Gönül Seyhan, Ole Petter Ottersen, Rupert Öllinger, Roland Rad, Sebastian Jarosch, Adrian Straub, Anton Mühlbauer, Simon Grassmann, Bernhard Hemmer, Jan P Böttcher, Ingrid Wagner, Mario Kreutzfeldt, Doron Merkler, Irene Bonafonte Pardàs, Marc Schmidt Supprian, Veit R Buchholz, Sylvia Heink, Dirk H Busch, Ludger Klein, Thomas Korn
Neuromyelitis optica is a paradigmatic autoimmune disease of the central nervous system, in which the water-channel protein AQP4 is the target antigen1 . The immunopathology in neuromyelitis optica is largely driven by autoantibodies to AQP42 . However, the T cell response that is required for the generation of these anti-AQP4 antibodies is not well understood. Here we show that B cells endogenously express AQP4 in response to activation with anti-CD40 and IL-21 and are able to present their endogenous AQP4 to T cells with an AQP4-specific T cell receptor (TCR)...
February 21, 2024: Nature
https://read.qxmd.com/read/38320863/use-of-6-minute-walk-distance-to-predict-lung-transplant-free-survival-in-fibrosing-non-ipf-interstitial-lung-diseases
#8
JOURNAL ARTICLE
Umberto Zanini, Fabrizio Luppi, Karina Kaur, Niccolò Anzani, Giovanni Franco, Giovanni Ferrara, Meena Kalluri, Marco Mura
BACKGROUND AND OBJECTIVE: The identification of progression in patients with fibrosing non-idiopathic pulmonary fibrosis (IPF) interstitial lung diseases (ILDs) represents an ongoing clinical challenge. Lung function decline alone may have significant limitations in the detection of clinically significant progression. We hypothesized that longitudinal changes of 6-min walk distance (6MWD) from baseline, simultaneously considered with measures of lung function, may independently predict survival and identifying clinically significant progression of disease...
February 6, 2024: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://read.qxmd.com/read/38317335/anti-spike-antibody-durability-after-sars-cov-2-vaccination-in-adolescent-solid-organ-transplant-recipients
#9
MULTICENTER STUDY
John McAteer, Divya D Kalluri, Rivka R Abedon, Caroline X Qin, Scott R Auerbach, Olga Charnaya, Lara A Danziger-Isakov, Noelle H Ebel, Amy G Feldman, Evelyn K Hsu, Saeed Mohammad, Emily R Perito, Ashley M Thomas, Teresa P Y Chiang, Jacqueline M Garonzik-Wang, Dorry L Segev, William A Werbel, Douglas B Mogul
BACKGROUND: Adolescent solid organ transplant recipients (aSOTRs) who received three doses of the COVID-19 mRNA vaccine experience high seroconversion rates and antibody persistence for up to 3 months. Long-term antibody durability beyond this timeframe following three doses of the SARS-CoV-2 mRNA vaccine remains unknown. We describe antibody responses 6 months following the third vaccine dose (D3) of the BNT162b2 mRNA vaccination among aSOTRs. METHODS: Participants in a multi-center, observational cohort who received the third dose of the vaccine were analyzed for antibodies to the SARS-CoV-2 spike protein receptor-binding domain (Roche Elecsys anti-SARS-CoV-2-S positive: ≥0...
February 2024: Pediatric Transplantation
https://read.qxmd.com/read/38301163/-letter-to-the-editor-together-we-are-better-in-interstitial-lung-disease-and-palliative-care-a-collaborative-approach-to-meet-care-needs-and-improve-education
#10
JOURNAL ARTICLE
Meena Kalluri, Sharon M Watanabe, Sarah Burton-MacLeod
No abstract text is available yet for this article.
February 2024: Journal of Palliative Medicine
https://read.qxmd.com/read/38283806/initial-institutional-experience-using-a-robotic-arm-enabled-4k-3d-exoscope-in-neurosurgical-operations
#11
JOURNAL ARTICLE
Jawad M Khalifeh, Ali Karim Ahmed, Wataru Ishida, Joshua Materi, Anita Kalluri, Daniel Lubelski, Timothy Witham, Nicholas Theodore, Debraj Mukherjee, Judy Huang
The extracorporeal telescope (exoscope) presents a novel digital camera system as a versatile alternative to traditional optical microscopy for microsurgery and minimally invasive neurosurgical operations. Recent innovations in exoscope technology offer 4K-definition multiscreen outputs, pneumatic robot arms, 3-dimensional depth perception, and greater illumination, focus, and magnification powers for enhanced intraoperative visualization. The authors present their initial institutional experience using a robotic arm-enabled 4K 3D exoscope in a variety of cranial and spinal neurosurgical operations, namely Chiari decompression, microvascular decompression for trigeminal neuralgia, anterior cervical discectomy, and lumbar decompressions...
January 2024: Neurosurgical focus: Video
https://read.qxmd.com/read/38273691/patterns-of-ophthalmic-emergencies-presenting-to-a-tertiary-eye-care-hospital-in-india
#12
JOURNAL ARTICLE
Kirandeep Kaur, Kalluri Satya Srividya, Neha Kabra, Ritika Saranath, Bharat Gurnani, Rengaraj Venkatesh
No abstract text is available yet for this article.
February 1, 2024: Indian Journal of Ophthalmology
https://read.qxmd.com/read/38245049/observer-studies-of-image-quality-of-denoising-reduced-count-cardiac-single-photon-emission-computed-tomography-myocardial-perfusion-imaging-by-three-dimensional-gaussian-post-reconstruction-filtering-and-deep-learning
#13
JOURNAL ARTICLE
P Hendrik Pretorius, Junchi Liu, Kesava S Kalluri, Yulei Jiang, Jeffery A Leppo, Seth T Dahlberg, Janusz Kikut, Matthew W Parker, Friederike K Keating, Robert Licho, Benjamin Auer, Clifford Lindsay, Arda Konik, Yongyi Yang, Miles N Wernick, Michael A King
BACKGROUND: The aim of this research was to asses perfusion-defect detection-accuracy by human observers as a function of reduced-counts for 3D Gaussian post-reconstruction filtering vs deep learning (DL) denoising to determine if there was improved performance with DL. METHODS: SPECT projection data of 156 normally interpreted patients were used for these studies. Half were altered to include hybrid perfusion defects with defect presence and location known. Ordered-subset expectation-maximization (OSEM) reconstruction was employed with the optional correction of attenuation (AC) and scatter (SC) in addition to distance-dependent resolution (RC)...
December 2023: Journal of Nuclear Cardiology
https://read.qxmd.com/read/38191982/comparability-of-elezanumab-safety-tolerability-and-pharmacokinetics-in-healthy-japanese-chinese-and-white-participants
#14
JOURNAL ARTICLE
Hari V Kalluri, Matthew R Rosebraugh, Nils Boehm, Charles Locke, Adam Ziemann, Hao Xiong
Elezanumab is a fully human monoclonal antibody, which is directed against repulsive guidance molecule A. The safety, tolerability, pharmacokinetics (PK), and immunogenicity of elezanumab were assessed in 2 Phase 1 clinical studies. The objective of this study was to assess the PK, safety, tolerability, and immunogenicity following intravenous infusion of elezanumab in healthy adult Japanese, Han Chinese, and Caucasian participants as well as Western participants from the single-ascending-dose study. Elezanumab exposures were approximately 20% higher in Japanese and Han Chinese participants compared to White participants without controlling for body weight...
January 8, 2024: Clinical Pharmacology in Drug Development
https://read.qxmd.com/read/38191175/mouse-models-to-evaluate-the-functional-role-of-the-tumor-microenvironment-in-cancer-progression-and-therapy-responses
#15
JOURNAL ARTICLE
Kathleen M McAndrews, Krishnan K Mahadevan, Raghu Kalluri
The tumor microenvironment (TME) is a complex ecosystem of both cellular and noncellular components that functions to impact the evolution of cancer. Various aspects of the TME have been targeted for the control of cancer; however, TME composition is dynamic, with the overall abundance of immune cells, endothelial cells (ECs), fibroblasts, and extracellular matrix (ECM) as well as subsets of TME components changing at different stages of progression and in response to therapy. To effectively treat cancer, an understanding of the functional role of the TME is needed...
January 8, 2024: Cold Spring Harbor Perspectives in Medicine
https://read.qxmd.com/read/38168235/single-extracellular-vesicle-imaging-and-computational-analysis-identifies-inherent-architectural-heterogeneity
#16
Kshipra S Kapoor, Seoyun Kong, Hikaru Sugimoto, Wenhua Guo, Vivek Boominathan, Yi-Lin Chen, Sibani Lisa Biswal, Tanguy Terlier, Kathleen M McAndrews, Raghu Kalluri
Evaluating the heterogeneity of extracellular vesicles (EVs) is crucial for unraveling their complex actions and biodistribution. Here, we identify consistent architectural heterogeneity of EVs using cryogenic transmission electron microscopy (cryo-TEM) which has an inherent ability to image biological samples without harsh labeling methods and while preserving their native conformation. Imaging EVs isolated using different methodologies from distinct sources such as cancer cells, normal cells, and body fluids, we identify a structural atlas of their dominantly consistent shapes...
December 12, 2023: bioRxiv
https://read.qxmd.com/read/38133684/socioeconomic-characteristics-and-postoperative-outcomes-of-patients-undergoing-prenatal-vs-postnatal-repair-of-myelomeningoceles
#17
JOURNAL ARTICLE
Anita L Kalluri, Kelly Jiang, Nancy Abu-Bonsrah, Adam Ammar, Rebecca Reynolds, Safwan Alomari, Michelle N Odonkor, Meghana Bhimreddy, Natasha Ram, Shenandoah Robinson, Syed Hassan A Akbari, Mari L Groves
PURPOSE: To investigate differences in sociodemographic characteristics and short-term outcomes between patients undergoing prenatal versus postnatal myelomeningocele repair. METHODS: Patients who underwent myelomeningocele repair at our institution were stratified based on prenatal or postnatal timing of repair. Baseline characteristics and outcomes were compared. Multivariate analysis was performed to identify whether prenatal repair was a predictor of outcomes independent of socioeconomic measures...
December 22, 2023: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://read.qxmd.com/read/38085926/neurovascular-compression-in-patients-with-trigeminal-neuralgia-may-be-associated-with-worse-outcomes-after-primary-percutaneous-rhizotomy
#18
JOURNAL ARTICLE
Sumil K Nair, Hussain Al-Khars, Anita Kalluri, Kathleen Ran, Collin Kilgore, Bhargavi R Budihal, Mostafa Abdulrahim, Vivek Yedavalli, Christopher M Jackson, Judy Huang, Michael Lim, Chetan Bettegowda, Risheng Xu
BACKGROUND AND OBJECTIVES: Percutaneous rhizotomy may be an effective primary intervention in patients with trigeminal neuralgia who are poor candidates for microvascular decompression or those who desire a less invasive approach. However, the influence of neurovascular compression on pain-free survival after primary percutaneous rhizotomy is not well understood. METHODS: We retrospectively reviewed all patients undergoing percutaneous rhizotomy at our institution from 1995 to 2022...
December 7, 2023: Neurosurgery
https://read.qxmd.com/read/38073266/predicting-fractures-using-vertebral-18f-naf-uptake-in-prostate-cancer-patients
#19
JOURNAL ARTICLE
Helene Chesnais, Nikita Bastin, Sofia Miguez, Daniel Kargilis, Anita Kalluri, Ashley Terry, Chamith S Rajapakse
BACKGROUND: Patients with prostate cancer tend to be at heightened risk for fracture due to bone metastases and treatment with androgen-deprivation therapy. Bone mineral density (BMD) derived from dual energy X-ray absorptiometry (DXA) is the standard for determining fracture risk in this population. However, BMD often fails to predict many osteoporotic fractures. Patients with prostate cancer also undergo 18F-sodium fluoride (18F-NaF)-positron emission tomography/computed tomography (PET/CT) to monitor metastases...
November 2023: Journal of Bone Metabolism
https://read.qxmd.com/read/38060070/prophylactic-removal-of-a-migratory-missile-from-the-cerebral-ventricles-case-report
#20
JOURNAL ARTICLE
Joshua Materi, A Karim Ahmed, Anita L Kalluri, Adam Ammar, Alan R Cohen
BACKGROUND AND IMPORTANCE: Nonpowder firearm injuries to the head pose major health risks, with retained fragments potentially causing harmful sequelae that require neurosurgical intervention. CLINICAL PRESENTATION: We report the case of 2-year-old girl who sustained an accidental gunshot wound to the head. She sustained a penetrating ballistic intracranial injury caused by a BB shot from a rifle. At presentation, she was neurologically intact with a punctate laceration on her left forehead...
December 7, 2023: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
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