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ConA liver

Giovanni Pirozzolo, Camilla Cona, Maurizio Rizzo, Fazli Shala, Sadri Berisha, Alfonso Recordare
Primary liver neuroendocrine tumors (PLNETs) are rare tumors of the liver. They share some common characteristics with neuroendocrine tumors (NETs) of the extrahepatic bile ducts, such as slow rise, hormonal, and histological features. Nevertheless, they possess some peculiarities and the major feature is the difference in the metastatic potential between PLNETs and NETs. PLNETs have less metastatic potential compared with NETs, which is the main factor based on which differential diagnosis between the two groups is achieved...
May 2018: Annals of Hepato-Biliary-Pancreatic Surgery
Qian Li, Guangying Chen, Hui Chen, Weijie Zhang, Yangyang Ding, Ping Yu, Ting Zhao, Guanghua Mao, Weiwei Feng, Liuqing Yang, Xiangyang Wu
To assess the immunomodulatory and antioxidant activities of a Se-polysaccharide from Se-enriched G. frondosa (Se-GFP-22), immunosuppressed mice models were generated by cyclophosphamide (CTX) administration and then treated with Se-GFP-22. Results showed that Se-GFP-22 could increase thymus and spleen indices, phagocytic index, co-mitogenic (ConA- or LPS-stimulated) activities on splenocytes, DTH reaction, serum hemolysin formation and immunoglobulin (Ig G, Ig A and Ig M) levels in CTX-treated mice. Se-GFP-22 significantly enhanced the antioxidant activity in CTX-treated mice, as shown by the evaluation of GSH-Px, SOD and CAT activities, as well as MDA levels in serum, liver and kidney...
September 15, 2018: Carbohydrate Polymers
Qian Li, Guangying Chen, Wei Wang, Weijie Zhang, Yangyang Ding, Ting Zhao, Fang Li, Guanghua Mao, Weiwei Feng, Qiang Wang, Liuqing Yang, Xiangyang Wu
In this study, a Se-deficient mice model was successfully developed by feeding a Se-deficient diet (0.02 mg Se/kg diet) for 4 weeks, and Se supplementation by Se-polysaccharides (Se-GFP-22) was lasted for 4 weeks. The immunomodulatory activity and Se supplementation of Se-GFP-22 from Se-enriched G. frondosa was investigated. Results showed that Se-GFP-22 remarkably enhanced glutathione peroxidase (GSH-Px) and thioredoxin reductase (TrxR) activities in liver, kidney and plasma, and serum, liver, spleen and kidney Se levels of Se-deficient mice...
May 25, 2018: International Journal of Biological Macromolecules
Jiao Feng, Peiqin Niu, Kan Chen, Liwei Wu, Tong Liu, Shizan Xu, Jingjing Li, Sainan Li, Wenwen Wang, Xiya Lu, Qiang Yu, Ning Liu, Ling Xu, Fan Wang, Weiqi Dai, Yujing Xia, Xiaoming Fan, Chuanyong Guo
Salidroside (Sal) is a glycoside extract from Rhodiola rosea L. with anti-inflammatory, antioxidant, anticancer and cardioprotective properties. The present study explored the protective effects and the possible mechanisms of Sal on concanavalin A (ConA)-induced liver injury in mice. Balb/C mice were divided into five groups: Normal control (injected with normal saline), ConA (25 mg/kg), Sal (10 mg/kg) +ConA, Sal (20 mg/kg) + ConA (Sal injected 2 h prior to ConA injection) and Sal (20 mg/kg) only. The serum levels of liver enzymes, pro-inflammatory cytokines, and apoptosis- and autophagy-associated marker proteins were determined at 2, 8 and 24 h after ConA injection...
June 2018: Experimental and Therapeutic Medicine
Wenwen Wang, Kan Chen, Yujing Xia, Wenhui Mo, Fan Wang, Weiqi Dai, Peiqin Niu
Objective: Previous studies have characterized the hepatoprotective and anti-inflammatory properties of oleanolic acid (OA). This study aimed to investigate the molecular mechanisms of OA hepatoprotection in concanavalin A- (ConA-) induced acute liver injury. Materials and Methods: ConA (20 mg/kg) was intravenously injected to induce acute liver injury in Balb/C mice. OA pretreatment (20, 40, and 80 mg/kg) was administered subcutaneously once daily for 3 consecutive days prior to treatment with ConA; 2, 8, and 24 h after ConA injection, the levels of serum liver enzymes and the histopathology of major factors and inflammatory cytokines were determined...
2018: PPAR Research
Mostafa R Fayed, Reem N El-Naga, El-Sayed Akool, Ebtehal El-Demerdash
Liver fibrosis results from chronic inflammation that precipitates excessive accumulation of extracellular matrix. Oxidative stress is involved in its pathogenesis. This study aimed to elucidate the potential antifibrotic effect of the NADPH oxidase (NOX) inhibitor, apocynin against concanavalin A (ConA)-induced immunological model of liver fibrosis, and to investigate the ability of the antioxidant, alpha-lipoic acid (α-LA) to potentiate this effect. Rats were treated with apocynin and/or α-LA for six weeks...
2018: Drug Discoveries & Therapeutics
Qingqiong Luo, Jieying Ding, Liping Zhu, Fuxiang Chen, Lili Xu
Eclipta prostrata L. is a traditional Chinese herbal medicine that has been used in the treatment of liver diseases. However, its biological mechanisms remain elusive. The current study aimed to investigate the hepatoprotective effect of wedelolactone, a major coumarin ingredient of Eclipta prostrata L., on immune-mediated liver injury. Using the well-established animal model of Concanavalin A (ConA)-induced hepatitis (CIH), we found that pretreatment of mice with wedelolactone markedly reduced both the serum levels of transaminases and the severity of liver damage...
May 8, 2018: American Journal of Chinese Medicine
Jessica R Salas, Bao Ying Chen, Alicia Wong, Donghui Cheng, John S Van Arnam, Owen N Witte, Peter M Clark
Immune cell-mediated attack on the liver is a defining feature of autoimmune hepatitis and hepatic allograft rejection. Despite an assortment of diagnostic tools, invasive biopsies remain the only method for identifying immune cells in the liver. We evaluated whether PET imaging with radiotracers that quantify immune activation (18 F-FDG and 18 F-FAC) and hepatocyte biology (18 F-DFA) can visualize and quantify hepatic infiltrating immune cells and hepatocyte inflammation, respectively, in a preclinical model of autoimmune hepatitis...
April 26, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
Jingyun Luan, Xuyao Zhang, Shaofei Wang, Yubin Li, Jiajun Fan, Wei Chen, Wenjing Zai, Sijia Wang, Yichen Wang, Mingkuan Chen, Guangxun Meng, Dianwen Ju
Autoimmune hepatitis (AIH) is a progressive inflammatory disorders of unknown etiology, characterized by immune-mediated destruction of hepatocytes and massive production of cytokines. Interleukin-1β is a pleiotropic proinflammatory cytokine and well known to be critical in a variety of autoimmune diseases. However, the role of interleukin-1β (IL-1β) in AIH is still indistinct. Here, we first investigated the significance of NOD-like receptor protein 3 (NLRP3) inflammasome-dependent IL-1β in the pathogenesis of AIH with a murine model of immune-mediated hepatitis induced by Concanavalin A (ConA)...
2018: Frontiers in Immunology
Xiya Lu, Tong Liu, Kan Chen, Yujing Xia, Weiqi Dai, Shizan Xu, Ling Xu, Fan Wang, Liwei Wu, Jingjing Li, Sainan Li, Wenwen Wang, Qiang Yu, Jiao Feng, Xiaoming Fan, Yingqun Zhou, Peiqin Niu, Chuanyong Guo
Isorhamnetin, a flavonoid compound extracted from plants' fruit or leaves, like sea buckthorn (Hippophae rhamnoides L.), has many biological functions, including anti-tumor, anti-oxidant and anti-inflammatory effect. The present study is in order to explore the hepatoprotective effect of isorhamnetin on concanavalin A (ConA)-induced acute fulminant hepatitis and the underlying mechanism. Mice were injected with ConA (25 mg/kg) to induce acute fulminant hepatitis, three doses of isorhamnetin (10/30/90 mg/kg) was intraperitoneally administrated about 1 h previously...
July 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Tinghong Ye, Tingting Wang, Xiaoxue Yang, Xiaoli Fan, Maoyao Wen, Yi Shen, Xiaotan Xi, Ruoting Men, Li Yang
BACKGROUND/AIMS: Autoimmune hepatitis (AIH) is a chronic necroinflammatory disease of the liver whose pathogenic mechanisms have not yet been elucidated. Moreover, the current treatment used for the vast majority of AIH patients is largely dependent on immunosuppressant administration and liver transplantation. However, research on the pathogenesis of AIH and effective new treatments for AIH have been hampered by a lack of animal models that accurately reproduce the human condition. METHODS: AIH models created by concanavalin A (ConA) injections at different times and doses...
2018: Cellular Physiology and Biochemistry
Lan Ding, Xiangying Zhang, Li Li, Chunyan Gou, Xiaolan Luo, Yang Yang, Tao Wen, Xiuhui Li
Qingchangligan formula (QCLGF) is a traditional Chinese medicine that has exhibited remarkable clinical efficacy for patients with acute-on-chronic liver failure (ACLF). However, the hepatoprotective mechanisms of QCLGF are not completely understood. Extracellular histones were recently identified as the novel inflammatory mediators involved in the pathogenesis of acute liver injury. This study aimed to investigate whether QCLGF provides hepatoprotection by targeting extracellular histones. We showed that QCLGF significantly improved the survival rate of the ConA-treated mice, ameliorated hepatotoxicity, and markedly decreased the levels of extracellular histones and the associated cytokines...
July 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Xixi Cheng, Huafeng Wang, Jinlai Yang, Yingnan Cheng, Dan Wang, Fengrui Yang, Yan Li, Dongmei Zhou, Yanxia Wang, Zhenyi Xue, Lijuan Zhang, Qi Zhang, Luhong Yang, Rongxin Zhang, Yurong Da
As a phenylpropanoid and dibenzylbutyrolactone lignan present in medical plants, such as those used in traditional Chinese herbal medicine, including Arctium lappa (Niubang), arctigenin exhibits antimicrobial, anti-inflammatory, and anticancer activities. In this study, we investigated the protective role of arctigenin in Concanavalin A (ConA)-induced acute hepatitis in mice. Arctigenin remarkably reduced the congestion and necroinflammation of livers, and improved hepatic function (ALT and AST) in ConA-induced acute hepatitis in vivo...
June 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Ian N Hines, Michael Kremer, Sherri M Moore, Michael D Wheeler
BACKGROUND: Peroxisome proliferator activated receptor alpha (PPARα), a regulator of enzymes involved in β oxidation, has been reported to influence lymphocyte activation. The purpose of this study was to determine whether PPARα plays a role in T cell-mediated hepatitis induced by Concanavalin A (ConA). METHODS: Wild type (wt) or PPARα-deficient (PPARα-/- ) mice were treated with ConA (15 mg/kg) by intravenous injection 0, 10 or 24 h prior to sacrifice and serum and tissue collection for analysis of tissue injury, cytokine response, T cell activation and characterization...
February 15, 2018: Biological Research
Tingting Wang, Ruoting Men, Mingxing Hu, Xiaoli Fan, Xiaoxue Yang, Xiaojun Huang, Tinghong Ye, Li Yang
Autoimmune hepatitis (AIH) is a chronic inflammatory liver disease of an unknown etiology, glucocorticoid therapy is currently recognized as an effective treatment for AIH, but conventional application and patient compliance are both hindered by its side effects. The exploration of the AIH pathogenesis and the searching for the new candidate drugs that exert potential activity and low toxicity are urgently needed. Pomegranate peel extract (PoPx) is a natural extract of Punica granatum and has been reported to have anti-inflammatory and antioxidative properties...
April 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Huan-Huan Tang, Hai-Long Li, Yue-Xuan Li, Yan You, Yun-Yun Guan, Su-Lin Zhang, Li-Xin Liu, Wei-Lian Bao, Yong Zhou, Xiao-Yan Shen
ETHNOPHARMACOLOGICAL RELEVANCE: Jiang-Xian HuGan (JXHG) formulated by five natural products including Freshwater clam (Corbicula fluminea), Curcuma longa L., Ligustrum lucidum, Eclipta prostrata (L.) L. and Paeonia lactiflora Pall., has exhibited a great hepatoprotective effect. AIM OF THIS STUDY: We investigated the effect of JXHG on concanavalin A (ConA)-induced acute live injury in mice, and to elucidate its underlying molecular mechanisms. MATERIALS AND METHODS: Jiangkanling Capsule (900 mg/kg), low-dose JXHG (LJXHG, 700 mg/kg), high-dose JXHG (HJXHG, 1400 mg/kg) were administered to mice by oral gavage daily for 20 days prior to a single intravenous injection of ConA (20 mg/kg)...
May 10, 2018: Journal of Ethnopharmacology
Delia Blaya, Beatriz Aguilar-Bravo, Fengjie Hao, Silvia Casacuberta-Serra, Mar Coll, Luis Perea, Júlia Vallverdú, Isabel Graupera, Elisa Pose, Laura Llovet, Jordi Barquinero, Francisco Javier Cubero, Juan Caballería, Pere Ginès, Pau Sancho-Bru
MicroRNA 155 (miR-155) is involved in immune and inflammatory diseases and is associated with liver fibrosis and steatohepatitis. However, the mechanisms involved in miR-155 regulation of liver injury are largely unknown. The role of miR-155 in acute liver injury was assessed in wild-type (WT), miR-155-/- , and miR-155-/- mice transplanted with WT bone marrow. Additionally, miR-155 expression was evaluated in liver tissue and peripheral blood mononuclear cells of patients with autoimmune hepatitis. Concanavalin A, but not acetaminophen, treatment increased the expression of miR-155 in liver tissue of WT mice...
February 8, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
Jung-Ran Noh, Yong-Hoon Kim, Don-Kyu Kim, Jung Hwan Hwang, Kyoung-Shim Kim, Dong-Hee Choi, Seon-Jin Lee, Hee Gu Lee, Tae Geol Lee, Hong-Lei Weng, Steven Dooley, Hueng-Sik Choi, Chul-Ho Lee
Although detailed pathophysiological mechanisms of fulminant hepatitis remain elusive, immune cell recruitment with excessive cytokine production is a well-recognized hallmark of the disease. We determined the function of orphan nuclear receptor small heterodimer partner (SHP) in concanavalin A (ConA)-induced hepatitis model. Male C57BL/6 J mice were injected intravenously with either a lethal dose (25 mg/kg) or a sub-lethal dose (15 mg/kg) of ConA. For the C-X-C motif chemokine ligand (CXCL) 2 neutralization study, mice were intravenously administered anti-mouse CXCL2 antibody (100 μg/mouse)...
May 1, 2018: Toxicological Sciences: An Official Journal of the Society of Toxicology
Cherry P Fernandez, Fahmida Afrin, Rochelle A Flores, Woo H Kim, Jipseol Jeong, Suk Kim, Hyun S Lillehoj, Wongi Min
As the dysregulation of IL-17 is implicated in the pathogenesis of various autoimmune and inflammatory diseases, the suppression of IL-17 production by Th2 cytokines could alleviate the development of these diseases. Previously, we confirmed that inflammatory cytokines including IL-17A are strongly associated with R. anatipestifer infection, which is one of the most important bacterial pathogens in the duck industry. Here, we found that IL-4 treatment downregulated the expression of IL-17A and IL-17F transcripts in splenic lymphocytes stimulated with R...
March 2018: Molecular Immunology
Andrea Kristina Horst, Claudia Wegscheid, Christoph Schaefers, Birgit Schiller, Katrin Neumann, Sebastian Lunemann, Annika E Langeneckert, Karl J Oldhafer, Christina Weiler-Normann, Karl S Lang, Bernhard B Singer, Marcus Altfeld, Linda Diehl, Gisa Tiegs
A dysbalance between effector T cells (Tconv) and regulatory T cells (Tregs) and impaired Tregs function can cause autoimmune liver disease. Therefore, it is important to identify molecular mechanisms that control Treg homeostasis. Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1, CD66a) is an immune co-receptor with dichotomous roles in T cell regulation: its short isoform (CEACAM1S) can activate T cells and induce Tregs, whereas its long isoform (CEACAM1L) containing two intracellular immune receptor tyrosine-based inhibitory motifs (ITIMs), can inhibit activated T cell function...
January 29, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
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