Hala M F Mohammad, Mohamed Ahmed Eladl, Asmaa K K Abdelmaogood, Rabie E Elshaer, Walaa Ghanam, Abdelhakeem Elaskary, Mohamed A K Saleh, Amira H Eltrawy, Sahar K Ali, Suzan M M Moursi, Shymaa E Bilasy, Sawsan A Zaitone, Wafa Ali Alzlaiq, Hayam Atteya
The possible impact of topiramate against diabetic retinopathy (DREN) and its molecular mechanisms in relation to the nod-like receptor family pyrin domain containing 3 (NLRP3) inflammasome has not been studied before. Thus, in the present study, we aimed to utilize a computational approach to investigate the possible protective effect of topiramate on experimental DREN and explore its impact on NLRP3/interlukin-1β signaling and brain-derived neurotrophic factor (BDNF) expression. Male albino mice were distributed to four experimental groups and assigned the following categorizations: (i) saline, (ii) diabetic, (iii) diabetic + topiramate 10 mg/kg and (iv) diabetic + topiramate 30 mg/kg...
December 1, 2023: Biomedicines