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Allicin

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https://www.readbyqxmd.com/read/28712378/treatment-of-allicin-improves-maturation-of-immature-oocytes-and-subsequent-developmental-ability-of-preimplantation-embryos
#1
Sang-Gi Jeong, Seung-Eun Lee, Yun-Gwi Park, Yeo-Jin Son, Min-Young Shin, Eun-Young Kim, Se-Pill Park
Allicin (AL) regulates the cellular redox, proliferation, viability, and cell cycle of different cells against extracellular-derived stress. This study investigated the effects of allicin treatment on porcine oocyte maturation and developmental competence. Porcine oocytes were cultured in medium supplemented with 0 (control), 0.01, 0.1, 1, 10 or 100 μM AL, respectively, during in vitro maturation (IVM). The rate of polar body emission was higher in the 0.1 AL-treated group (74.5% ± 2.3%) than in the control (68...
July 17, 2017: Zygote: the Biology of Gametes and Early Embryos
https://www.readbyqxmd.com/read/28693193/allicin-inhibits-the-invasion-of-lung-adenocarcinoma-cells-by-altering-tissue-inhibitor-of-metalloproteinase-matrix-metalloproteinase-balance-via-reducing-the-activity-of-phosphoinositide-3-kinase-akt-signaling
#2
Ling Huang, Yuanhong Song, Jianping Lian, Zhiwei Wang
Allicin, the main active principle associated with Allium sativum chemistry, has various antitumor activities. However, to the best of our knowledge, there is no available information to address the anti-invasive effect and associated mechanism in lung adenocarcinoma. In the present study, cell viability assay, cell adhesion assay, western blot analysis, Transwell migration and invasion assays and reverse transcription-quantitative polymerase chain reaction were performed. Allicin was identified to inhibit the adhesion, invasion and migration of lung adenocarcinoma cells in a dose-dependent manner, accompanied by decreasing mRNA and protein levels of matrix metalloproteinase (MMP)-2 and MMP-9...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28607407/resistance-of-garlic-cultivars-to-bradysia-odoriphaga-and-its-correlation-with-garlic-thiosulfinates
#3
Guodong Zhu, Yin Luo, Ming Xue, Fangyuan Zhou, Haipeng Zhao, Guixia Ji, Fang Liu
Garlic, a widely cultivated global vegetable crop, is threatened by the underground pest Bradysia odoriphaga in China. Previous reports indicated that garlic essential oil, of which the dominant components are sulfides or thiosulfinates, exhibits insecticidal activity against pests. However, it is unclear whether the resistance of garlic to B. odoriphaga is related to thiosulfinates. Here, we compared the resistance of 10 garlic cultivars at various growth stages to B. odoriphaga by field investigation and indoor life-table data collection...
June 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28572959/bioactive-phytochemicals-in-an-aqueous-extract-of-the-leaves-of-talinum-triangulare
#4
Catherine C Ikewuchi, Jude C Ikewuchi, Mercy O Ifeanacho
An aqueous leaf extract of Talinum triangulare was screened for the presence of bioactive molecules, using gas chromatography coupled with pulse and flame ionization detectors. It had high carotenoids; moderate benzoic acid derivatives, hydroxycinnamates and flavonoids; and low terpenes, alkaloids, phytosterols, allicins, glycosides, saponins, and lignans contents. Ten known carotenoids (mainly 50.42% carotene and 33.30% lycopene), nine benzoic acid derivatives (mainly 84.63% ferulic acid and 11.92% vanillic acid), and six hydroxycinnamates (55...
May 2017: Food Science & Nutrition
https://www.readbyqxmd.com/read/28511293/enterobacter-aerogenes-zdy01-attenuates-choline-induced-trimethylamine-n-oxide-levels-via-remodeling-gut-microbiota-in-mice
#5
Liang Qiu, Dong Yang, Xueying Tao, Jun Yu, Hua Xiong, Hua Wei
Trimethylamine N-oxide (TMAO), which is transformed from trimethylamine (TMA) through hepatic flavin-containing monooxygenases, can promote atherosclerosis. TMA is produced from dietary carnitine, phosphatidylcholine, and choline via the gut microbes. Previous works have shown that some small molecules, such as allicin, resveratrol, and 3,3-dimethyl-1-butanol, are used to reduce circulating TMAO levels. However, the use of bacteria as an effective therapy to reduce TMAO levels has not been reported. In the present study, 82 isolates were screened from healthy Chinese fecal samples on a basal salt medium supplemented with TMA as sole carbon source...
May 17, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28492800/fungal-infection-control-by-garlic-extracts-allium-sativum-l-and-modulation-of-peritoneal-macrophages-activity-in-murine-model-of-sporotrichosis
#6
J P Burian, L V S Sacramento, I Z Carlos
Garlic (Allium sativum L.) is grown all over the world as seasoning and medicinal vegetable since 3,000 BC. Allicin is the main component of garlic, being attributed to it the most of its biological activities, such as bactericidal, antifungal and antiviral actions. However, other compounds of garlic present antioxidant, hypocholesterolemic, vasodilator activities, protective action against different types of cancer, and immunomodulatory. Fungal infections are important causes of morbidity and mortality in people mainly in immunosuppressed ones...
May 4, 2017: Brazilian Journal of Biology, Revista Brasleira de Biologia
https://www.readbyqxmd.com/read/28489336/antimicrobial-activity-of-natural-products-against-clostridium-difficile-in-vitro
#7
Niloufar Roshan, Thomas V Riley, Katherine A Hammer
AIMS: To investigate the antimicrobial activity of various natural products against C. difficile in vitro. METHODS AND RESULTS: The antibacterial activity of 20 natural products was determined by the agar well diffusion and broth microdilution assays against four C. difficile strains, three comparator organisms and four gastrointestinal commensal organisms. Of the raw natural products, garlic juice had the highest activity. The most active processed products were peppermint oil and the four pure compounds trans-cinnamaldehyde, allicin, menthol and zingerone...
May 10, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/28489057/an-optimized-facile-procedure-to-synthesize-and-purify-allicin
#8
Frank Albrecht, Roman Leontiev, Claus Jacob, Alan J Slusarenko
Allicin is a reactive sulfur species (RSS) and defence substance from garlic (Allium sativum L.). The compound is a broad-spectrum antibiotic that is also effective against multiple drug resistant (MDR) strains. A detailed protocol for allicin synthesis based on diallyl-disulfide (DADS) oxidation by H₂O₂ using acetic acid as a catalyst was published in 2001 by Lawson and Wang. Here we report on improvements to this basic method, clarify the mechanism of the reaction and show that it is zero-order with respect to DADS and first-order with respect to the concentration of H₂O₂...
May 10, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28479370/yap1p-the-central-regulator-of-the-s-cerevisiae-oxidative-stress-response-is-activated-by-allicin-a-natural-oxidant-and-defence-substance-of-garlic
#9
Martin C H Gruhlke, Ivan Schlembach, Roman Leontiev, Andreas Uebachs, Peter U G Gollwitzer, Alexander Weiss, Agnes Delaunay, Michel Toledano, Alan J Slusarenko
Allicin is a thiol-reactive sulfur-containing natural product from garlic with a broad range of antimicrobial effects against prokaryotes and eukaryotes. Previous work showed that the S. cerevisiae OSI1 gene is highly induced by allicin and other thiol-reactive compounds, and in silico analysis revealed multiple Yap1p binding motifs in the OSI1 promoter sequence. An OSI1-promoter::luciferase reporter construct expressed in Wt and Δyap1 cells showed absolute Yap1p-dependence for allicin-induced OSI1-expression...
May 4, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28462145/antihypertensive-effect-of-allicin-in-dexamethasone-induced-hypertensive-rats
#10
Harikesh Dubey, Anamika Singh, Angad M Patole, Chandrashekhar R Tenpe
BACKGROUND: Glucocorticoid is among the most commonly prescribed medicine. Unfortunately, Excess glucocorticoid level leads hypertension in 80-90% patients. Garlic (Allium sativum) has been used since ancient times and even nowadays as a part of popular medicine for various ailments and physiological disorders. Hence this study was undertaken to investigate the antihypertensive activity of allicin in dexamethasone induced hypertension in wistar rats. METHODS: The animals were randomly divided into four groups comprising of six rats per group...
March 2017: Integrative medicine research
https://www.readbyqxmd.com/read/28456799/allicin-decreases-lipopolysaccharide-induced-oxidative-stress-and-inflammation-in-human-umbilical-vein-endothelial-cells-through-suppression-of-mitochondrial-dysfunction-and-activation-of-nrf2
#11
Min Zhang, Huichao Pan, Yinjie Xu, Xueting Wang, Zhaohui Qiu, Li Jiang
BACKGROUND: Allicin, a major component of garlic, is regarded as a cardioprotective agent and is associated with increased endothelial function. METHODS: The effects of allicin on lipopolysaccharide (LPS)-induced vascular oxidative stress and inflammation in cultured human umbilical vein endothelial cells (HUVECs) and the mechanisms underlying these effects were studied. The protective effects were measured using cell viability, a lactate dehydrogenase (LDH) assay and cell apoptosis as indicators, and the anti-oxidative activity was determined by measuring reactive oxygen species (ROS) generation, oxidative products and endogenous antioxidant enzyme activities...
2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28449595/pharmaceutical-perspectives-of-spices-and-condiments-as-alternative-antimicrobial-remedy
#12
Savita P D'Souza, Suvarna V Chavannavar, B Kanchanashri, S B Niveditha
Medicinal values of spices and condiments are being revived by biologists through in vitro and in vivo trials providing evidence for its antimicrobial activities. The essential oils and extracts of spices like black pepper, cloves, cinnamon, and nutmeg contain active compounds like piperine, eugenol, cinnamaldehyde, and lignans. Similarly, condiments like coriander, black cumin, turmeric, garlic, and ginger are recognized for constituents like linalool, thymoquinones, curcumin, allicin, and geranial respectively...
January 1, 2017: Journal of Evidence-based Complementary & Alternative Medicine
https://www.readbyqxmd.com/read/28443813/vacuolar-h-atpase-subunit-vma1p-functions-as-the-molecular-ligand-in-the-vacuole-targeting-fungicidal-activity-of-polymyxin-b
#13
Maki Iida, Keiichi Yamada, Yoshiya Nango, Yoshihiro Yamaguchi, Akira Ogita, Ken-Ichi Fujita, Toshio Tanaka
Polymyxin B (PMB) is a cationic cyclic peptide that can selectively inhibit the growth of Gram-negative bacteria by disrupting the outer membrane permeability barrier through binding to lipopolysaccharide (LPS). Here, a fluorescent PMB derivative (PMB-Ds) was applied to visually confirm the vacuole as a direct lethal target of PMB against fungal cells, which lack LPS. PMB-Ds could be visualized in the normal rounded vacuolar membrane of Saccharomyces cerevisiae cells, suggesting the presence of a molecular ligand assisting the vacuole-targeting mobilization of the peptide in the organism...
April 2017: Microbiology
https://www.readbyqxmd.com/read/28440421/allicin-induces-the-upregulation-of-abca1-expression-via-ppar%C3%AE-lxr%C3%AE-signaling-in-thp-1-macrophage-derived-foam-cells
#14
Xiao-Long Lin, Hui-Jun Hu, Yuan-Bo Liu, Xue-Mei Hu, Xiao-Juan Fan, Wei-Wen Zou, Yong-Quan Pan, Wen-Quan Zhou, Min-Wen Peng, Cai-Hong Gu
Allicin is considered anti-atherosclerotic due to its antioxidant and anti-inflammatory effects, which makes it an important drug for the prevention and treatment of atherosclerosis. However, the effects of allicin on foam cells are unclear. Thus, in this study, we examined the effects of allicin on lipid accumulation via peroxisome proliferator-activated receptor γ (PPARγ)/liver X receptor α (LXRα) in THP‑1 macrophage-derived foam cells. THP‑1 cells were exposed to 100 nM phorbol myristate acetate (PMA) for 24 h, and then to oxydized low-density lipoprotein (ox-LDL; 50 mg/ml) to induce foam cell formation...
June 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28421744/a-mini-hip-hop-assay-uncovers-a-central-role-for-copper-and-zinc-in-the-antifungal-mode-of-action-of-allicin
#15
Thomas A K Prescott, Barry Panaretou
Garlic contains the organosulfur compound allicin which exhibits potent antifungal activity. Here we demonstrate the use of a highly simplified yeast chemical genetic screen to characterize its mode of action. By screening 24 validated yeast gene deletion "signature" strains for which hypersensitivity is characteristic for common antifungal modes of action, yeast lacking the high affinity Cu(2+) transporter Ctr1 was found to be hypersensitive to allicin. Focusing on transition metal related genes identified two more hypersensitive strains lacking the Cu(2+) and Zn(2+) transcription factors Mac1 and Zap1...
May 10, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28259711/allicin-protects-against-cisplatin-induced-vestibular-dysfunction-by-inhibiting-the-apoptotic-pathway
#16
Xianmin Wu, Jing Cai, Xiaofei Li, He Li, Jianfeng Li, Xiaohui Bai, Wenwen Liu, Yuechen Han, Lei Xu, Daogong Zhang, Haibo Wang, Zhaomin Fan
Cisplatin is an anticancer drug that causes the impairment of inner ear function as side effects, including hearing loss and balance dysfunction. The purpose of this study was to investigate the effects of allicin against cisplatin-induced vestibular dysfunction in mice and to make clear the mechanism underlying the protective effects of allicin on oto-vestibulotoxicity. Mice intraperitoneally injected with cisplatin exhibited vestibular dysfunction in swimming test, which agreed with impairment in vestibule...
March 1, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28219698/protective-effects-of-diallyl-disulfide-against-acetaminophen-induced-nephrotoxicity-a-possible-role-of-cyp2e1-and-nf-%C3%AE%C2%BAb
#17
Je-Won Ko, Jin-Young Shin, Jeong-Won Kim, Sung-Hyeuk Park, Na-Rae Shin, In-Chul Lee, In-Sik Shin, Changjong Moon, Sung-Ho Kim, Sung-Hwan Kim, Jong-Choon Kim
Diallyl disulfide (DADS) is a degradation product of allicin which is contained in garlic. This study investigated the protective effects of DADS against acetaminophen (AAP)-induced nephrotoxicity and the molecular mechanisms of nephroprotective effects in rats. AAP caused severe nephrotoxicity as evidenced by significant increases in renal tubular cell apoptosis, mitochondria-mediated apoptosis, and up-regulation of nuclear transcription factor kappa-B (NF-κB), cyclooxygenase-2 (Cox-2), and tumor necrosis factor-α (TNF-α) in the kidney with histopathological alterations...
April 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28185379/feed-degradability-rumen-fermentation-and-blood-metabolites-in-response-to-essential-oil-addition-to-fistulated-non-lactating-dairy-cow-diets
#18
Wisitiporn Suksombat, Atitthan Nanon, Chayapol Meeprom, Pipat Lounglawan
The effects of essential oils (EOs) on ruminal nutrient disappearance, rumen fermentation and blood metabolites in fistulated non-lactating dairy cows were studied. Four fistulated non-lactaing dairy cows were used in a 4 × 4 Latin square design; the experiment consisted of four periods of 21 days in each period, with the first 14 days for adaptation followed by 7 days of measurement period. Animals were fed 3 kg/day of 21% crude protein (CP) concentrate and ad libitum corn silage. Treatments were: (i) control; (ii) 2 mL Allicin/cow/day; (iii) 2 mL zingiberene/cow/day; and (iv) 2 mL citral/cow/day...
February 9, 2017: Animal Science Journal, Nihon Chikusan Gakkaihō
https://www.readbyqxmd.com/read/28154518/drug-target-identification-and-elucidation-of-natural-inhibitors-for-bordetella-petrii-an-in-silico-study
#19
Surya Narayan Rath, Manisha Ray, Animesh Pattnaik, Sukanta Kumar Pradhan
Environmental microbes like Bordetella petrii has been established as a causative agent for various infectious diseases in human. Again, development of drug resistance in B. petrii challenged to combat against the infection. Identification of potential drug target and proposing a novel lead compound against the pathogen has a great aid and value. In this study, bioinformatics tools and technology have been applied to suggest a potential drug target by screening the proteome information of B. petrii DSM 12804 (accession No...
December 2016: Genomics & Informatics
https://www.readbyqxmd.com/read/28139552/inhibition-of-hydrogen-peroxide-induced-human-umbilical-vein-endothelial-cells-aging-by-allicin-depends-on-sirtuin1-activation
#20
Xiao-Long Lin, Yuanbo Liu, Mihua Liu, HuiJun Hu, Yongquan Pan, Xiao-Juan Fan, Xue-Mei Hu, Wei-Wen Zou
BACKGROUND The abnormal activity of Sirtuin 1 (Sirt1) is closely related to the aging of vascular endothelial cells. As a bioactive molecule, allicin has antioxidant, anti-inflammatory, and lipid-regulating mechanisms. However, few reports about the relationship of allicin and Sirt1 have been published. In this study, we aimed to elucidate the effect of allicin on Human Umbilical Vein Endothelial Cells (HUVECs) aging induced by hydrogen peroxide (H2O2) and the role of Sirt1 in this phenomenon. MATERIAL AND METHODS HUVEC were exposed to H2O2 to establish the aging model...
January 31, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
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