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Allicin

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https://www.readbyqxmd.com/read/28062185/allicin-protects-auditory-hair-cells-and-spiral-ganglion-neurons-from-cisplatin-induced-apoptosis
#1
Xianmin Wu, Xiaofei Li, Yongdong Song, He Li, Xiaohui Bai, Wenwen Liu, Yuechen Han, Lei Xu, Jianfeng Li, Daogong Zhang, Haibo Wang, Zhaomin Fan
Cisplatin is a broad-spectrum anticancer drug that is commonly used in the clinic. Ototoxicity is one of the major side effects of this drug, which caused irreversible sensorineural hearing loss. Allicin, the main biologically active compound derived from garlic, has been shown to exert various anti-apoptotic and anti-oxidative activities in vitro and in vivo studies. We took advantage of C57 mice intraperitoneally injected with cisplatin alone or with cisplatin and allicin combined, to investigate whether allicin plays a protective role in vivo against cisplatin ototoxicity...
January 3, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28035949/the-effects-of-allicin-a-reactive-sulfur-species-from-garlic-on-a-selection-of-mammalian-cell-lines
#2
Martin C H Gruhlke, Carole Nicco, Frederic Batteux, Alan J Slusarenko
Garlic (Allium sativum L.) has been used as a spice and medicinal plant since ancient times. Garlic produces the thiol-reactive defence substance, allicin, upon wounding. The effects of allicin on human lung epithelium carcinoma (A549), mouse fibroblast (3T3), human umbilical vein endothelial cell (HUVEC), human colon carcinoma (HT29) and human breast cancer (MCF7) cell lines were tested. To estimate toxic effects of allicin, we used a standard MTT-test (methylthiazoltetrazolium) for cell viability and ³H-thymidine incorporation for cell proliferation...
December 26, 2016: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/28017989/antioxidant-effects-of-supercritical-fluid-garlic-extracts-in-canned-artichokes
#3
E Bravi, O Marconi, V Sileoni, M R Rollo, G Perretti
The effects of adding supercritical carbon dioxide extracts of garlic (at two different concentrations of allicin) on select chemical indices in extra-virgin olive oil used to canned artichokes were studied. Tests were performed after processing and over a storage period of 1 year. A sensorial test was also conducted on the canned artichokes to establish the impact on flavor (in particular perceptions of rancidity and garlic flavor). Acidity, peroxide levels and p-anisidine values were measured as quality analytical parameters...
October 2016: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/27998111/carbon-dot-coated-alginate-beads-as-a-smart-stimuli-responsive-drug-delivery-system
#4
Sristi Majumdar, Gargee Krishnatreya, Neelam Gogoi, Debajit Thakur, Devasish Chowdhury
In this work, we report a smart stimuli-responsive drug delivery system (DDS) that can release drug depending upon the amount of pathogen (MRSA) present in the target. A greater amount of MRSA in the system will lead to more release of drug and vice versa. Carbon-dot-coated novel alginate beads (CA-CD) exhibiting superior stability was successfully used as smart drug delivery vehicle. Garlic extract (GE), which contains allicin, was taken as model drug system to demonstrate the phenomena. It was observed that GE loading was 19 and 78% with CA and CA-CD, respectively...
December 21, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27995158/data-on-the-effect-of-boiling-on-the-organosulfides-and-the-hydrogen-sulfide-releasing-activity-of-garlic
#5
Restituto Tocmo, Yuchen Wu, Dong Liang, Vincenzo Fogliano, Dejian Huang
This article contains experimental data on the identification and quantification of the organosulfides on boiled garlic extracts. Data included are related to the research article "Boiling enriches the linear polysulfides and the hydrogen sulfide-releasing activity of garlic" (R. Tocmo, Y. Wu, D. Liang, V. Fogliano, D. Huang, 2016) [1]. Characterization was carried out by GC-MS and HPLC. Dose-response curves obtained from the cell-based H2S-releasing capacity assay of allicin transformation products, namely vinyl dithiins and ajoene are also included...
February 2017: Data in Brief
https://www.readbyqxmd.com/read/27990229/effects-of-allicin-on-hypertension-and-cardiac-function-in-chronic-kidney-disease
#6
Ehécatl M A García-Trejo, Abraham S Arellano-Buendía, Raúl Argüello-García, María L Loredo-Mendoza, Fernando E García-Arroyo, Mónica G Arellano-Mendoza, María C Castillo-Hernández, Gustavo Guevara-Balcázar, Edilia Tapia, Laura G Sánchez-Lozada, Horacio Osorio-Alonso
This work was performed to study the effect of allicin on hypertension and cardiac function in a rat model of CKD. The groups were control, CKD (5/6 nephrectomy), and CKD-allicin treated (CKDA) (40 mg/kg day/p.o.). Blood pressure was monitored (weekly/6 weeks). The cardiac function, vascular response to angiotensin II, oxidative stress, and heart morphometric parameters were determined. The CKD group showed hypertension and proteinuria. The coronary perfusion and left ventricular pressures were decreased in CKD group...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/27892697/allium-roseum-l-extract-exerts-potent-suppressive-activities-on-chronic-myeloid-leukemia-k562-cell-viability-through-the-inhibition-of-bcr-abl-pi3k-akt-and-erk1-2-pathways-and-the-abrogation-of-vegf-secretion
#7
Soumaya Souid, Hanen Najjaa, Ichrak Riahi-Chebbi, Meriam Haoues, Mohamed Neffati, Ingrid Arnault, Jacques Auger, Habib Karoui, Makram Essafi, Khadija Essafi-Benkhadir
Use of plant extracts, alone or combined to the current chemotherapy as chemosensitizers, has emerged as a promising strategy to overcome tumor drug resistance. Here, we investigated the anticancer activity of Allium roseum L. extracts, a wild edible species in North Africa, on human Chronic Myeloid Leukemia (CML) K562 cells. The dehydrated aqueous extract (DAE) disturbed the cell cycle progression and induced the apoptosis of K562 cells. Chemical analysis of DAE showed a diversity of organosulfur compounds S-alk(en)yl-cysteine sulfoxides (RCSO) and high amount of allicin, suggesting that such molecule may be behind its antitumor effect...
January 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/27868250/effects-of-astragalus-membranaceus-codonopsis-pilosula-and-allicin-mixture-on-growth-performance-nutrient-digestibility-faecal-microbial-shedding-immune-response-and-meat-quality-in-finishing-pigs
#8
R X Lan, J W Park, D W Lee, I H Kim
A 12-week trial with 120 [(Landrace×Yorkshire)×Duroc] pigs (45.65 ± 1.93 kg) was conducted to evaluate the effects of Astragalus membranaceus, Codonopsis pilosula and allicin mixture (HM) supplementation on growth performance, nutrient digestibility, faecal microbial shedding, immune response and meat quality in finishing pigs. Pigs were allocated to one of three treatments with 0, 0.025% (HM1) and 0.05% (HM2) HM supplementation in a randomized complete block design according to sex and BW. Each treatment contained 10 replications with four pigs (two barrows and two gilts) per pen...
November 21, 2016: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/27855892/cooked-garlic-and-antioxidant-activity-correlation-with-organosulfur-compound-composition
#9
D A Locatelli, M A Nazareno, C M Fusari, A B Camargo
The antioxidant properties and the main beneficial organosulphur compounds of home-cooked garlic samples were studied in order to establish relationships between them. Antioxidant activity was tested by free radical scavenging against 2,2-diphenyl-1-picrylhydrazyl radical (DPPH) and 2,2'-azino-bis-(3-ethylbenzo-thiazoline-6-sulfonic acid) diammonium salt (ABTS(+)), Fe(III) reducing ability (FRAP) and linoleic acid co-oxidation initiated by soybean lipoxygenase in a micelle system. DPPH, ABTS and FRAP assays showed the highest activity for raw garlic samples, while β-carotene bleaching assay yielded the highest activity for stir-fried garlic...
April 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27765964/properties-and-storage-stability-of-whey-protein-edible-film-with-spice-powders
#10
Apisada Ket-On, Natkritta Pongmongkol, Anongnat Somwangthanaroj, Theeranun Janjarasskul, Kanitha Tananuwong
The impact of spice powders on physical, mechanical, thermal and barrier properties, and on storage stability, of whey protein isolate (WPI)-based films was determined. Films with added spices were prepared from casting solution containing 10 % (w/w) heat-denatured WPI, glycerol (WPI:glycerol of 3:2 w/w), sodium chloride (0.4 g/100 g solution), garlic and pepper powders (≤3 g each/100 g solution). Water activity (aw) of all films was 0.53-0.57. Addition of spice powders increased thickness, darkness and yellowness of the WPI films...
July 2016: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/27756563/allicin-inspired-thiolated-fluoroquinolones-as-antibacterials-against-eskape-pathogens
#11
Jordan G Sheppard, Timothy E Long
Thiolated fluoroquinolones were synthesized from ciprofloxacin and evaluated for antimicrobial activity against a panel of pathogenic bacteria. Gram-positive species including methicillin-resistant Staphylococcus aureus (MRSA) exhibited the highest level of increased sensitivity toward ciprofloxacin bound with a N-propylthio substituent. Evidence was found that the antibiotics form disulfides with low molecular weight thiols in bacteria and potentiate generation of cytosolic reactive oxygen species (ROS). In final analysis, the enhanced anti-MRSA activity of thiolated fluoroquinolones was attributed to increased cell permeability and reaction with cytosolic thiols that yields an inactive disulfide metabolite and the parent drug ciprofloxacin as an inhibitor of DNA synthesis...
November 15, 2016: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/27725449/evaluation-of-the-effects-of-s-allyl-l-cysteine-s-methyl-l-cysteine-trans-s-1-propenyl-l-cysteine-and-their-n-acetylated-and-s-oxidized-metabolites-on-human-cyp-activities
#12
Hirotaka Amano, Daichi Kazamori, Kenji Itoh
Three major organosulfur compounds of aged garlic extract, S-allyl-L-cysteine (SAC), S-methyl-L-cysteine (SMC), and trans-S-1-propenyl-L-cysteine (S1PC), were examined for their effects on the activities of five major isoforms of human CYP enzymes: CYP1A2, 2C9, 2C19, 2D6, and 3A4. The metabolite formation from probe substrates for the CYP isoforms was examined in human liver microsomes in the presence of organosulfur compounds at 0.01-1 mM by using liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis...
2016: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/27723197/therapeutic-hotline-oral-allicin-in-the-treatment-of-behcet-s-disease-through-attenuating-oxidative-stress-a-pilot-study-in-20-patients-with-mucocutaneous-lesions
#13
Jianqiao Zhong, Dehai Xian, Xia Xiong, Junxiang Liu
Behçet's disease (BD) involves oxidative stress (OS) aggression and imbalanced oxidant/antioxidant status. Owing to its antioxidant property, allicin is proposed for treating BD. In this study, we aimed to investigate the efficacy and safety of allicin on patients with BD with mucocutaneous involvement. Twenty patients with active BD were treated with allicin for 12 weeks and followed up to 16 weeks. A clinical manifestations index and scoring system was the primary technique for efficacy evaluation at baseline and Week 4, 12, 16...
October 9, 2016: Dermatologic Therapy
https://www.readbyqxmd.com/read/27712876/allicin-ameliorates-intraintestinal-bacterial-translocation-after-trauma-hemorrhagic-shock-in-rats-the-role-of-mesenteric-lymph-node-dendritic-cell
#14
Yun Zhang, Jian Zhang, Tao Xu, Wei Wu, Fang-Fang Huang, Wen-Qiao Yu, Shao-Yang Zhang, Ting-Bo Liang
BACKGROUND: Intestinal dendritic cells play important roles in regulating the function of the intestinal immune barrier and the intestinal bacterial translocation. In this study, we aim to investigate the effects of allicin on the function of mesenteric lymph node-dendritic cells after trauma/hemorrhagic shock. METHODS: One hundred and eight-four Sprague-Dawley rats were randomly assigned into a sham group (n = 46), sham + allicin group (n = 46), trauma/hemorrhagic shock group (n = 46), and trauma/hemorrhagic shock + allicin group (n = 46)...
February 2017: Surgery
https://www.readbyqxmd.com/read/27664612/salting-out-extraction-of-allicin-from-garlic-allium-sativum-l-based-on-ethanol-ammonium-sulfate-in-laboratory-and-pilot-scale
#15
Fenfang Li, Qiao Li, Shuanggen Wu, Zhijian Tan
Salting-out extraction (SOE) based on lower molecular organic solvent and inorganic salt was considered as a good substitute for conventional polymers aqueous two-phase extraction (ATPE) used for the extraction of some bioactive compounds from natural plants resources. In this study, the ethanol/ammonium sulfate was screened as the optimal SOE system for the extraction and preliminary purification of allicin from garlic. Response surface methodology (RSM) was developed to optimize the major conditions. The maximum extraction efficiency of 94...
February 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27610111/garlic-from-remedy-to-stimulant-evaluation-of-antifungal-potential-reveals-diversity-in-phytoalexin-allicin-content-among-garlic-cultivars-allicin-containing-aqueous-garlic-extracts-trigger-antioxidants-in-cucumber
#16
Sikandar Hayat, Zhihui Cheng, Husain Ahmad, Muhammad Ali, Xuejin Chen, Mengyi Wang
Garlic has the charisma of a potent remedy and holds its repute of a therapeutic panacea since the dawn of civilization. An integrated approach was adopted to evaluate the genetic diversity among Chinese garlic cultivars for their antifungal potency as well as allicin content distribution and, furthermore; a bioassay was performed to study the bio-stimulation mechanism of aqueous garlic extracts (AGE) in the growth and physiology of cucumber (Cucumis sativus). Initially, 28 garlic cultivars were evaluated against four kinds of phytopathogenic fungi; Fusarium oxysporum, Botrytis cinerea, Verticillium dahliae and Phytophthora capsici, respectively...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27596067/allicin-ameliorates-kidney-function-and-urinary-bladder-sensitivity-in-cyclosporine-a-treated-rats
#17
D H El-Kashef, A E El-Kenawi, G M Suddek, H A Salem
Cyclosporine-A (CsA) is an immunosuppressive drug which has been used to prevent rejection after organ transplantation and to treat certain autoimmune diseases. However, its therapeutic use is limited by nephrotoxicity. In this study, the modulator effect of allicin on the oxidative nephrotoxicity of CsA in rats was investigated. Furthermore, the effect of allicin on CsA-induced hypersensitivity of urinary bladder rings to acetylcholine (ACh) was estimated. Rats were divided into three groups, control, CsA (15 mg/kg, subcutaneously), and CsA/allicin (50 mg/kg, orally)...
September 5, 2016: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/27584700/diet-supplementation-with-allicin-protects-against-alcoholic-fatty-liver-disease-in-mice-by-improving-anti-inflammation-and-antioxidative-functions
#18
Suraphan Panyod, Wei-Kai Wu, Chi-Tang Ho, Kuan-Hung Lu, Chun-Ting Liu, Yung-Lin Chu, Yi-Syuan Lai, Wei-Cheng Chen, Yu-En Lin, Shih-Hang Lin, Lee-Yan Sheen
This study investigated the liver-protective effects of allicin, an active compound in fresh garlic, against alcoholic fatty liver disease (AFLD) and liver inflammation. Its effects were investigated in an AFLD model in male C57BL/6 mice, which were fed Lieber-DeCarli liquid diet containing ethanol. Allicin (5 and 20 mg/kg bw/day) was orally administered daily in the AFLD mice for 4 weeks. The results indicate that allicin promotes hepatoprotection by significantly reducing aspartate transaminase (AST) and alanine transaminase (ALT) levels (p < 0...
September 28, 2016: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/27573340/allicin-protects-traumatic-spinal-cord-injury-through-regulating-the-hsp70-akt-inos-pathway-in-mice
#19
Shunyi Wang, Dongliang Ren
Allicin is a major component of garlic, extracted as an oily liquid. The present study was designed to investigate the beneficial effects of allicin on traumatic spinal cord injury (TSCI) in mice, and whether the effects are mediated via regulation of the heat shock protein 70 (HSP70), v‑akt murine thymoma viral oncogene homolog 1 (Akt) and inducible nitric oxide synthase (iNOS) pathways. Adult BALB/c mice (30‑40 g) received a laminectomy at the T9 vertebral level as a model of TSCI. In the present study, treatment of the TSCI mice with allicin significantly increased their Basso, Beattie and Bresnahan (BBB) scores (P<0...
October 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27561292/activation-of-the-nrf2-signaling-pathway-involving-klf9-plays-a-critical-role-in-allicin-resisting-against-arsenic-trioxide-induced-hepatotoxicity-in-rats
#20
Daqian Yang, Zhanjun Lv, Haili Zhang, Biying Liu, Huijie Jiang, Xiao Tan, Jingjing Lu, Ruiqi Baiyun, Zhigang Zhang
Arsenic trioxide (As2O3) is both the most prevalent, naturally occurring inorganic arsenical threatening human health and an efficient therapeutic for acute promyelocytic leukemia. Regretfully, As2O3-treated cancer patients often suffer from hepatotoxicity. While effective antioxidant and anticarcinogenic actions of allicin have previously been demonstrated, studies indicating how allicin affects As2O3-induced hepatotoxicity and arsenic accumulation are lacking. Our study, for the first time, elaborates potential details of the hepatoprotective mechanisms of allicin against As2O3-induced liver injury...
August 25, 2016: Biological Trace Element Research
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