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Lina Ma, Shangke Chen, Shaochun Li, Lijuan Deng, Yikui Li, Hao Li
Allicin (2-propene-1-sulfinothioic acid S -2-propenyl ester, diallyl thiosulfinate) is the main biologically active ingredient in garlic. The present study investigated the protective effect of allicin against cardiomyocyte apoptosis that was induced by ischemia in vitro and the potential molecular mechanisms that were involved in this antiapoptotic effect. The results indicated that allicin increased H9c2 cell activity and attenuated the rate of apoptosis that was induced by ischemia/hypoxia. Intracellular calcium concentrations significantly decreased in the allicin-treated groups...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Huinan Chen, Biqiang Zhu, Lei Zhao, Yang Liu, Fuya Zhao, Jing Feng, Ye Jin, Jiayu Sun, Rui Geng, Yunwei Wei
BACKGROUND/AIMS: Cholangiocarcinoma (CCA) is a malignant tumor that is resistant to chemotherapy, so new therapeutic agents are needed. Allicin which is rapidly converted from allin by allinase, is one of the most biologically active compounds in freshly crushed garlic and has been shown to have strong anti-tumor effects. Our aim was to explore the molecular mechanism by which allicin affects the cell proliferation and invasion of CCA. METHODS: Cell viability and apoptosis were measured using the CCK-8 assay, colony formation assay, and flow cytometry...
May 22, 2018: Cellular Physiology and Biochemistry
Ignacio Gutiérrez-Del-Río, Javier Fernández, Felipe Lombó
Synthetic food additives generate a negative perception in consumers. Therefore, food manufacturers search for safer natural alternatives as those involving phytochemicals and plant essential oils. These bioactives have antimicrobial activities widely proved in in vitro tests. Foodborne diseases cause thousands of deaths and millions of infections every year, mainly due to pathogenic bacteria as Salmonella spp., Campylobacter spp., Escherichia coli, Bacillus cereus, Listeria monocytogenes or Staphylococcus aureus...
May 16, 2018: International Journal of Antimicrobial Agents
Shaojuan Liu, Liuqin He, Qian Jiang, Veeramuthu Duraipandiyan, Naif Abdullah Al-Dhabi, Gang Liu, Kang Yao, Yulong Yin
BACKGROUND: Recently, it is hot and urgent to search for the substitutes of antibiotics. In our previous study, dietary AKG combined with allicin improved growth performance and enhanced immunity of growing pigs, whereas the effects of them on intestinal microbiota is unclear. Here, we further investigate the the effects of dietary AKG and allicin supplementation on the intestinal microbiota composition and diversity of growing pigs. RESULTS: Co-treatment of AKG and allicin enhanced cecal bacteria richness and diversity, and evidenced by the changed Chao 1, ACE, Shannon, and Simpson values when compared to the control group and antibiotics group...
May 13, 2018: Journal of the Science of Food and Agriculture
Roman Leontiev, Nils Hohaus, Claus Jacob, Martin C H Gruhlke, Alan J Slusarenko
Allicin (diallylthiosulfinate) is a defence molecule from garlic (Allium sativum L.) with broad antimicrobial activities in the low µM range against Gram-positive and -negative bacteria, including antibiotic resistant strains, and fungi. Allicin reacts with thiol groups and can inactivate essential enzymes. However, allicin is unstable at room temperature and antimicrobial activity is lost within minutes upon heating to >80 °C. Allicin's antimicrobial activity is due to the thiosulfinate group, so we synthesized a series of allicin analogues and tested their antimicrobial properties and thermal stability...
April 30, 2018: Scientific Reports
Dina M Metwally, Ebtesam M Al-Olayan, Mohammad Alanazi, Sanaa B Alzahrany, Abdelhabib Semlali
BACKGROUND: Schistosomiasis is an acute and chronic zoonotic parasitic disease caused by trematode worms. The host inflammatory response to schistosome eggs leads to perioval granulomata formation, mainly in the liver and intestine. This study investigated the potential antischistosomal and anti-inflammatory activity of both garlic extract and allicin on liver fibrotic markers in BALB/c mice with schistosomiasis (S. mansoni infection) compared with that of the commonly used drug, praziquantel (PZQ)...
April 27, 2018: BMC Complementary and Alternative Medicine
Xiang Li, Jiahui Ni, Yixin Tang, Xu Wang, Huanhuan Tang, Haidong Li, Sulin Zhang, Xiaoyan Shen
Allicin is the major biologically active compounds of freshly crushed garlic. It has been reported to inhibit the proliferation and promote the apoptosis of multiple colorectal cancer cells. However, the anti-colorectal cancer effect of Allicin has not been verified by in vivo studies. In the present study, we investigated the effect of Allicin on azoxymethane/dextran sodium sulfate (AOM/DSS) colorectal cancer mouse model and explore the underlying possible mechanism. Our result showed that Allicin could inhibit colonic tumorigenesis of AOM/DSS mice in vivo...
April 23, 2018: Natural Product Research
Niloufar Roshan, Thomas V Riley, Katherine A Hammer
AIMS: To investigate the effect of natural products on the spore cycle of C. difficile in vitro. METHODS AND RESULTS: Twenty-two natural products were investigated using four C. difficile strains. Effects on sporulation, determined using microscopy and a conventional spore recovery assay, showed that fresh onion bulb extract (6.3% v v-1 ) and coconut oil (8% v v-1 ) inhibited sporulation in all four isolates by 66-86% and 51-88%, respectively, compared to untreated controls...
April 19, 2018: Journal of Applied Microbiology
Kensuke Seki, Junya Ishikawa, Youji Okada
We re-examined the antioxidative mechanism of allicin as a radical scavenger on the basis of the reactivity toward 2, 2-diphenyl-1-picrylhydrazyl (DPPH) and peroxyl radicals. Initially, it was found that allicin decomposed more rapidly in n-hexane and chlorobenzene than in acetonitrile, ethanol, and ethanol/water solutions and decomposed into ajoene and vinyldithiins in these solvents. Furthermore, the decomposition of allicin and the following formations of ajoene and vinyldithiins from allicin were accelerated by the reaction of allicin with DPPH and peroxyl radicals...
May 2018: Journal of Food Science
Voin Petrovic, Anala Nepal, Camilla Olaisen, Siri Bachke, Jonathan Hira, Caroline K Søgaard, Lisa M Røst, Kristine Misund, Trygve Andreassen, Torun M Melø, Zdenka Bartsova, Per Bruheim, Marit Otterlei
The use of garlic and garlic-based extracts has been linked to decreased incidence of cancer in epidemiological studies. Here we examine the molecular and cellular activities of a simple homemade ethanol-based garlic extract (GE). We show that GE inhibits growth of several different cancer cells in vitro, as well as cancer growth in vivo in a syngeneic orthotopic breast cancer model. Multiple myeloma cells were found to be especially sensitive to GE. The GE was fractionated using solid-phase extractions, and we identified allicin in one GE fraction; however, growth inhibitory activities were found in several additional fractions...
April 5, 2018: Nutrients
Marco Malavolta, Massimo Bracci, Lory Santarelli, Md Abu Sayeed, Elisa Pierpaoli, Robertina Giacconi, Laura Costarelli, Francesco Piacenza, Andrea Basso, Maurizio Cardelli, Mauro Provinciali
The reactivation of senescence in cancer and the subsequent clearance of senescent cells are suggested as therapeutic intervention in the eradication of cancer. Several natural compounds that activate Nrf2 (nuclear factor erythroid-derived 2-related factor 2) pathway, which is involved in complex cytoprotective responses, have been paradoxically shown to induce cell death or senescence in cancer. Promoting the cytoprotective Nrf2 pathway may be desirable for chemoprevention, but it might be detrimental in later stages and advanced cancers...
2018: Mediators of Inflammation
Yangfeng Xiang, Jianqiang Zhao, Ming Zhao, Kejing Wang
Allicin has been reported to inhibit cancer cell proliferation, induce cell apoptosis and enhance the accumulation of reactive oxygen species. However, it has remained elusive whether allicin improves multidrug resistance in thyroid cancer cells through modulating autophagy. The present study demonstrated that combined use of allicin and cisplatin or carboplatin resulted in an enhanced growth inhibitory effect on SW1736 and HTh-7 cells. Furthermore, treatment with allicin significantly increased SW1736 and HTh-7 cell autophagy...
April 2018: Experimental and Therapeutic Medicine
Anisur Rahman, Mohammad A Faqeerzada, Byoung-Kwan Cho
BACKGROUND: Allicin and soluble solid content (SSC) in garlic is the responsible for its pungent flavor and odor. However, current conventional methods such as the use of high-pressure liquid chromatography and a refractometer have critical drawbacks in that they are time-consuming, labor-intensive and destructive procedures. The present study aimed to predict allicin and SSC in garlic using hyperspectral imaging in combination with variable selection algorithms and calibration models...
March 14, 2018: Journal of the Science of Food and Agriculture
Xudong Wang, Chao Zhang, Chao Chen, Yi Guo, Xiaoyan Meng, Chen Kan
Allicin is an oxygenated carotenoid derivative that exhibits strong antioxidant activity, which effectively removes reactive oxygen species from the body and has important roles in disease prevention and treatment. Therefore, the present study aimed to investigate whether allicin attenuates lipopolysaccharide (LPS)‑induced acute lung injury (ALI) in neonatal rats and the potential underlying mechanisms. An LPS‑induced ALI neonatal rat model was utilized to assess the therapeutic value and mechanisms of allicin...
May 2018: Molecular Medicine Reports
Chenlong Li, Hanguang Jing, Guangtao Ma, Peng Liang
Allicin is an extract purified from Allium sativum (garlic), and previous research has indicated that Allicin has an inhibitory effect on many kinds of tumor cells. The aim of the present study was to explore the anticancer activity of Allicin on human glioma cells and investigate the underlying mechanism. MTT and colony-formation assays were performed to detect glioma cell proliferation, and explore the effect of Allicin at various doses and time-points. The apoptosis of glioma cells was measured by fluorescence microscopy with Hoechst 33258 staining, and then flow cytometry was used to analyzed changes in glioma cell apoptosis...
April 2018: Molecular Medicine Reports
Liming Zhang, Ping Guan, Zhihan Zhang, Yujie Dai, Limin Hao
Complexes of amylose (Am) with garlic bioactive components (GBCs) were prepared by milling activating treatment of Am and garlic paste (GP) together. The complex, produced by milling for 2.5h with the garlic (dry basis)/Am ratio of 1:5 (w/w) and water content of 25% (w/w) exhibited significantly higher allicin content (0.49mg/g of complex) than others. The scanning electron microscopy (SEM), X-ray diffraction (XRD), Fourier transforms infrared (FT-IR), differential scanning calorimetry (DSC), thermogravimetry analysis (TGA), high performance liquid chromatography (HPLC), and gas chromatography-mass spectrometry (GC-MS) techniques were used complex characterization...
March 2018: Food Research International
Hao Zhang, Ping Wang, Yixue Xue, Libo Liu, Zhen Li, Yunhui Liu
In middle and old age, Alzheimer's disease (AD) is a progressive neurodegenerative disorder of brain. As an increasingly aging population, AD represents a huge burden for the patients' family and the country. However, current therapeutical strategies have shown limited effectiveness. Allicin, which is the main composition of garlic, was reported to prevent the learning and memory impairment of AD mouse model. As the mechanism is not clear, in this study, we used the APP (amyloid precursor protein)/PS1 (presenilin 1) double transgenic mice, which express human mutant APP and PS1, to determine the protective effect of allicin on neurons...
February 2018: Tissue & Cell
Masashi Fukaya, Seikou Nakamura, Ryota Nakagawa, Souichi Nakashima, Masayuki Yamashita, Hisashi Matsuda
Three sulfur-containing compounds, kujounins A1 (1) and A2 (2) and allium sulfoxide A1 (3), were isolated from the acetone extract of Allium fistulosum 'Kujou'. Their chemical structures were elucidated on the basis of physicochemical evidence, including X-ray crystallographic data. Compounds 1 and 2 possess three rings and an acetal structure and were obtained as complex compounds having disulfide and monosaccharide moieties. On the other hand, compound 3 has a thiolane skeleton derived from allicin. Naturally occurring compounds 1-3 have rare molecular skeletons...
January 5, 2018: Organic Letters
Eric Block, Benjamin Bechand, Sivaji Gundala, Abith Vattekkatte, Kai Wang, Shaymaa S Mousa, Kavitha Godugu, Murat Yalcin, Shaker A Mousa
We describe the synthesis, reactivity, and antithrombotic and anti-angiogenesis activity of difluoroallicin ( S -(2-fluoroallyl) 2-fluoroprop-2-ene-1-sulfinothioate) and S -2-fluoro-2-propenyl-l-cysteine, both easily prepared from commercially available 3-chloro-2-fluoroprop-1-ene, as well as the synthesis of 1,2-bis(2-fluoroallyl)disulfane, 5-fluoro-3-(1-fluorovinyl)-3,4-dihydro-1,2-dithiin, trifluoroajoene (( E , Z )-1-(2-fluoro-3-((2-fluoroallyl)sulfinyl)prop-1-en-1-yl)-2-(2-fluoroallyl)disulfane), and a bis(2-fluoroallyl)polysulfane mixture...
November 28, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Jing Lu, Bijun Cheng, Baochen Fang, Zhuoqun Meng, Yiying Zheng, Xiaochen Tian, Shuang Guan
Allicin (2-propene-1-sulfinothioic acid S-2-propenyl ester), with quite a good range of hepatoprotective and antineoplastic properties, is a functional substance from garlic (Allium sativum L.) The purpose of this study was to provide evidence that allicin could protect 1,3-DCP-induced lipid metabolism disorder in HepG2 cells. Allicin reduced the accumulation of triglycerides (TG) and total cholesterol (TC) in 1,3-DCP-induced HepG2 cells. Allicin significantly increased the phosphorylation of AMP-activated protein kinase (AMPK) and down-regulated the levels of sterol regulatory element binding protein-1 (SREBP-1) and sterol regulatory element binding protein-2 (SREBP-2) in 1,3-DCP-induced HepG2 cells...
December 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
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