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Allicin

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https://www.readbyqxmd.com/read/29660783/contribution-of-2-propenesulfenic-acid-to-the-antioxidant-activity-of-allicin
#1
Kensuke Seki, Junya Ishikawa, Youji Okada
We re-examined the antioxidative mechanism of allicin as a radical scavenger on the basis of the reactivity toward 2, 2-diphenyl-1-picrylhydrazyl (DPPH) and peroxyl radicals. Initially, it was found that allicin decomposed more rapidly in n-hexane and chlorobenzene than in acetonitrile, ethanol, and ethanol/water solutions and decomposed into ajoene and vinyldithiins in these solvents. Furthermore, the decomposition of allicin and the following formations of ajoene and vinyldithiins from allicin were accelerated by the reaction of allicin with DPPH and peroxyl radicals...
April 16, 2018: Journal of Food Science
https://www.readbyqxmd.com/read/29621132/anti-cancer-potential-of-homemade-fresh-garlic-extract-is-related-to-increased-endoplasmic-reticulum-stress
#2
Voin Petrovic, Anala Nepal, Camilla Olaisen, Siri Bachke, Jonathan Hira, Caroline K Søgaard, Lisa M Røst, Kristine Misund, Trygve Andreassen, Torun M Melø, Zdenka Bartsova, Per Bruheim, Marit Otterlei
The use of garlic and garlic-based extracts has been linked to decreased incidence of cancer in epidemiological studies. Here we examine the molecular and cellular activities of a simple homemade ethanol-based garlic extract (GE). We show that GE inhibits growth of several different cancer cells in vitro, as well as cancer growth in vivo in a syngeneic orthotopic breast cancer model. Multiple myeloma cells were found to be especially sensitive to GE. The GE was fractionated using solid-phase extractions, and we identified allicin in one GE fraction; however, growth inhibitory activities were found in several additional fractions...
April 5, 2018: Nutrients
https://www.readbyqxmd.com/read/29618945/inducers-of-senescence-toxic-compounds-and-senolytics-the-multiple-faces-of-nrf2-activating-phytochemicals-in-cancer-adjuvant-therapy
#3
REVIEW
Marco Malavolta, Massimo Bracci, Lory Santarelli, Md Abu Sayeed, Elisa Pierpaoli, Robertina Giacconi, Laura Costarelli, Francesco Piacenza, Andrea Basso, Maurizio Cardelli, Mauro Provinciali
The reactivation of senescence in cancer and the subsequent clearance of senescent cells are suggested as therapeutic intervention in the eradication of cancer. Several natural compounds that activate Nrf2 (nuclear factor erythroid-derived 2-related factor 2) pathway, which is involved in complex cytoprotective responses, have been paradoxically shown to induce cell death or senescence in cancer. Promoting the cytoprotective Nrf2 pathway may be desirable for chemoprevention, but it might be detrimental in later stages and advanced cancers...
2018: Mediators of Inflammation
https://www.readbyqxmd.com/read/29545880/allicin-activates-autophagic-cell-death-to-alleviate-the-malignant-development-of-thyroid-cancer
#4
Yangfeng Xiang, Jianqiang Zhao, Ming Zhao, Kejing Wang
Allicin has been reported to inhibit cancer cell proliferation, induce cell apoptosis and enhance the accumulation of reactive oxygen species. However, it has remained elusive whether allicin improves multidrug resistance in thyroid cancer cells through modulating autophagy. The present study demonstrated that combined use of allicin and cisplatin or carboplatin resulted in an enhanced growth inhibitory effect on SW1736 and HTh-7 cells. Furthermore, treatment with allicin significantly increased SW1736 and HTh-7 cell autophagy...
April 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29542139/hyperspectral-imaging-for-predicting-the-allicin-and-soluble-solid-content-of-garlic-with-variable-selection-algorithms-and-chemometric-models
#5
Anisur Rahman, Mohammad Akbar Faqeerzada, Byoung-Kwan Cho
BACKGROUND: Allicin and soluble solid content (SSC) in garlic is the responsible for its pungent flavor and odor. However, current conventional methods such as high-pressure liquid chromatography (HPLC), refractometer has a critical drawbacks in that they are time-consuming, labor-intensive and destructive procedures. The present study aimed to predict the allicin and soluble solid content (SSC) in garlic using hyperspectral imaging in combination with variable selection algorithms and calibration models...
March 14, 2018: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29512749/allicin-attenuates-lipopolysaccharide%C3%A2-induced-acute-lung-injury-in-neonatal-rats-via-the-pi3k-akt-pathway
#6
Xudong Wang, Chao Zhang, Chao Chen, Yi Guo, Xiaoyan Meng, Chen Kan
Allicin is an oxygenated carotenoid derivative that exhibits strong antioxidant activity, which effectively removes reactive oxygen species from the body and has important roles in disease prevention and treatment. Therefore, the present study aimed to investigate whether allicin attenuates lipopolysaccharide (LPS)‑induced acute lung injury (ALI) in neonatal rats and the potential underlying mechanisms. An LPS‑induced ALI neonatal rat model was utilized to assess the therapeutic value and mechanisms of allicin...
March 7, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29436625/allicin-induces-apoptosis-through-activation-of-both-intrinsic-and-extrinsic-pathways-in-glioma-cells
#7
Chenlong Li, Hanguang Jing, Guangtao Ma, Peng Liang
Allicin is an extract purified from Allium sativum (garlic), and previous research has indicated that Allicin has an inhibitory effect on many kinds of tumor cells. The aim of the present study was to explore the anticancer activity of Allicin on human glioma cells and investigate the underlying mechanism. MTT and colony-formation assays were performed to detect glioma cell proliferation, and explore the effect of Allicin at various doses and time-points. The apoptosis of glioma cells was measured by fluorescence microscopy with Hoechst 33258 staining, and then flow cytometry was used to analyzed changes in glioma cell apoptosis...
February 2, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29433241/physicochemical-characteristics-of-complexes-between-amylose-and-garlic-bioactive-components-generated-by-milling-activating-method
#8
Liming Zhang, Ping Guan, Zhihan Zhang, Yujie Dai, Limin Hao
Complexes of amylose (Am) with garlic bioactive components (GBCs) were prepared by milling activating treatment of Am and garlic paste (GP) together. The complex, produced by milling for 2.5h with the garlic (dry basis)/Am ratio of 1:5 (w/w) and water content of 25% (w/w) exhibited significantly higher allicin content (0.49mg/g of complex) than others. The scanning electron microscopy (SEM), X-ray diffraction (XRD), Fourier transforms infrared (FT-IR), differential scanning calorimetry (DSC), thermogravimetry analysis (TGA), high performance liquid chromatography (HPLC), and gas chromatography-mass spectrometry (GC-MS) techniques were used complex characterization...
March 2018: Food Research International
https://www.readbyqxmd.com/read/29429523/allicin-ameliorates-cognitive-impairment-in-app-ps1-mice-via-suppressing-oxidative-stress-by-blocking-jnk-signaling-pathways
#9
Hao Zhang, Ping Wang, Yixue Xue, Libo Liu, Zhen Li, Yunhui Liu
In middle and old age, Alzheimer's disease (AD) is a progressive neurodegenerative disorder of brain. As an increasingly aging population, AD represents a huge burden for the patients' family and the country. However, current therapeutical strategies have shown limited effectiveness. Allicin, which is the main composition of garlic, was reported to prevent the learning and memory impairment of AD mouse model. As the mechanism is not clear, in this study, we used the APP (amyloid precursor protein)/PS1 (presenilin 1) double transgenic mice, which express human mutant APP and PS1, to determine the protective effect of allicin on neurons...
February 2018: Tissue & Cell
https://www.readbyqxmd.com/read/29227665/rare-sulfur-containing-compounds-kujounins-a-1-and-a-2-and-allium-sulfoxide-a-1-from-allium-fistulosum-kujou
#10
Masashi Fukaya, Seikou Nakamura, Ryota Nakagawa, Souichi Nakashima, Masayuki Yamashita, Hisashi Matsuda
Three sulfur-containing compounds, kujounins A1 (1) and A2 (2) and allium sulfoxide A1 (3), were isolated from the acetone extract of Allium fistulosum 'Kujou'. Their chemical structures were elucidated on the basis of physicochemical evidence, including X-ray crystallographic data. Compounds 1 and 2 possess three rings and an acetal structure and were obtained as complex compounds having disulfide and monosaccharide moieties. On the other hand, compound 3 has a thiolane skeleton derived from allicin. Naturally occurring compounds 1-3 have rare molecular skeletons...
January 5, 2018: Organic Letters
https://www.readbyqxmd.com/read/29182588/fluorinated-analog-nmr-s-of-organosulfur-compounds-from-garlic-allium-sativum-synthesis-chemistry-and-anti-angiogenesis-and-antithrombotic-studies
#11
Eric Block, Benjamin Bechand, Sivaji Gundala, Abith Vattekkatte, Kai Wang, Shaymaa S Mousa, Kavitha Godugu, Murat Yalcin, Shaker A Mousa
We describe the synthesis, reactivity, and antithrombotic and anti-angiogenesis activity of difluoroallicin ( S -(2-fluoroallyl) 2-fluoroprop-2-ene-1-sulfinothioate) and S -2-fluoro-2-propenyl-l-cysteine, both easily prepared from commercially available 3-chloro-2-fluoroprop-1-ene, as well as the synthesis of 1,2-bis(2-fluoroallyl)disulfane, 5-fluoro-3-(1-fluorovinyl)-3,4-dihydro-1,2-dithiin, trifluoroajoene (( E , Z )-1-(2-fluoro-3-((2-fluoroallyl)sulfinyl)prop-1-en-1-yl)-2-(2-fluoroallyl)disulfane), and a bis(2-fluoroallyl)polysulfane mixture...
November 28, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29169723/protective-effects-of-allicin-on-1-3-dcp-induced-lipid-metabolism-disorder-in-hepg2-cells
#12
Jing Lu, Bijun Cheng, Baochen Fang, Zhuoqun Meng, Yiying Zheng, Xiaochen Tian, Shuang Guan
Allicin (2-propene-1-sulfinothioic acid S-2-propenyl ester), with quite a good range of hepatoprotective and antineoplastic properties, is a functional substance from garlic (Allium sativum L.) The purpose of this study was to provide evidence that allicin could protect 1,3-DCP-induced lipid metabolism disorder in HepG2 cells. Allicin reduced the accumulation of triglycerides (TG) and total cholesterol (TC) in 1,3-DCP-induced HepG2 cells. Allicin significantly increased the phosphorylation of AMP-activated protein kinase (AMPK) and down-regulated the levels of sterol regulatory element binding protein-1 (SREBP-1) and sterol regulatory element binding protein-2 (SREBP-2) in 1,3-DCP-induced HepG2 cells...
December 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29155156/allicin-functionalized-locust-bean-gum-nanoparticles-for-improved-therapeutic-efficacy-an-in-silico-in-vitro-and-in-vivo-approach
#13
R S Soumya, S Sherin, K G Raghu, Annie Abraham
The field of nanotechnology has overgrown over the past few years and has even ventured into the field of medicine. The aim of the present study is to develop a novel allicin functionalized locust bean gum nanoparticle using the nanoprecipitation technique. The synthesized nanoparticles were characterized by dynamic light scattering, scanning electron microscopy and transmission electron microscopy. The characterization study revealed the nanoscale structure (∼100nm) of the prepared particles. In silico toxicology analysis were carried out to assess the drug-like properties and virtual toxicity of allicin...
April 1, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29126733/allicin-inspired-pyridyl-disulfides-as-antimicrobial-agents-for-multidrug-resistant-staphylococcus-aureus
#14
Jordan G Sheppard, Jeremy P McAleer, Pushkar Saralkar, Werner J Geldenhuys, Timothy E Long
A chemical library comprised of nineteen synthesized pyridyl disulfides that emulate the chemical reactivity of allicin (garlic) was evaluated for antimicrobial activity against a panel of pathogenic bacteria. Gram-positive species including vancomycin-intermediate and vancomycin-resistant Staphylococcus aureus (VISA, VRSA) demonstrated the highest level of susceptibility toward analogs with S-alkyl chains of 7-9 carbons in length. Further biological studies revealed that the disulfides display synergy with vancomycin against VRSA, cause dispersal of S...
January 1, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29111753/biogenic-nanostructured-porous-silicon-as-a-carrier-for-stabilization-and-delivery-of-natural-therapeutic-species
#15
Nguyen T Le, Jhansi R Kalluri, Armando Loni, Leigh T Canham, Jeffery L Coffer
Nanostructured mesoporous silicon (pSi) derived from the silicon-accumulator plant Tabasheer (Bambuseae) is demonstrated to serve as a potential carrier matrix for carrying and stabilizing naturally active, but otherwise metastable, therapeutic agents. Particularly, in this study, garlic oil containing phytochemicals (namely, allicin) that are capable of inhibiting Staphylococcus aureus (S. aureus) bacterial growth were incorporated into Tabasheer-derived porous silicon. Thermogravimetric analysis (TGA) indicated that relatively high amounts of the extract (53...
December 4, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29077629/mechanism-of-action-of-topical-garlic-on-wound-healing
#16
Minhal Alhashim, Jamie Lombardo
BACKGROUND: Allicin, the active component of garlic, has been shown to have antimicrobial and anti-inflammatory properties. Garlic has also been used historically by many cultures to heal wounds. Several animal studies have shown that garlic extracts increase the rate of wound healing and decrease the rate of infection. OBJECTIVE: Fibroblasts play a key role in wound healing. Here we hypothesize that fibroblasts are being activated by allicin, leading to more organized and rapid wound repair...
October 26, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/29056888/effect-of-garlic-supplement-in-the-management-of-type-2-diabetes-mellitus-t2dm-a-meta-analysis-of-randomized-controlled-trials
#17
Juan Wang, Xiuming Zhang, Haili Lan, Weijia Wang
The present study was designed to systematically evaluate the clinical efficacy and safety of garlic supplement in the management of type 2 diabetes mellitus (T2DM). PubMed, EMBASE, the Cochrane Library, and China National Knowledge Internet (CNKI) were searched for relevant randomized controlled trials (RCTs) by using the terms garlic and T2DM up to April 2017. The quality of included RCTs was assessed by the Cochrane tool of risk of bias, and data of outcomes were pooled by REVMAN 5.3. Clinical factors were handled by meta-regression and subgroup analysis, and risk of publication bias was explored by inverted funnel plots...
2017: Food & Nutrition Research
https://www.readbyqxmd.com/read/29038534/performance-and-consistency-of-a-fluorescence-based-high-throughput-screening-assay-for-use-in-babesia-drug-screening-in-mice
#18
Mohamed Abdo Rizk, Shimaa Abd El-Salam El-Sayed, Mahmoud AbouLaila, Rasha Eltaysh, Naoaki Yokoyama, Ikuo Igarashi
In this study, we evaluated the validity of a fluorescence-based assay using SYBR Green I (SG I) stain for screening antibabesial compounds against B. microti in mice. Two different hematocrits (HCTs; 2.5% and 5%) were used. Correlating relative fluorescence units (RFUs) with parasitemia showed significant linear relationships with R2 values of 0.97 and 0.99 at HCTs of 2.5% and 5%, respectively. Meanwhile, the Z' factors in a high-throughput screening (HTS) assay were within the permissible limit (≥0.5) at 2...
October 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29023413/diallylthiosulfinate-allicin-a-volatile-antimicrobial-from-garlic-allium-sativum-kills-human-lung-pathogenic-bacteria-including-mdr-strains-as-a-vapor
#19
Jana Reiter, Natalja Levina, Mark van der Linden, Martin Gruhlke, Christian Martin, Alan J Slusarenko
Garlic (Allium sativum) has potent antimicrobial activity due to allicin (diallylthiosulfinate) synthesized by enzyme catalysis in damaged garlic tissues. Allicin gives crushed garlic its characteristic odor and its volatility makes it potentially useful for combating lung infections. Allicin was synthesized (>98% pure) by oxidation of diallyl disulfide by H₂O₂ using formic acid as a catalyst and the growth inhibitory effect of allicin vapor and allicin in solution to clinical isolates of lung pathogenic bacteria from the genera Pseudomonas, Streptococcus, and Staphylococcus, including multi-drug resistant (MDR) strains, was demonstrated...
October 12, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28962124/allicin-protects-against-h2o2-induced-apoptosis-of-pc12-cells-via-the-mitochondrial-pathway
#20
Runxiao Lv, Lili Du, Chunwen Lu, Jinhui Wu, Muchen Ding, Chao Wang, Ningfang Mao, Zhicai Shi
Allicin is a major bioactive ingredient of garlic and has a broad range of biological activities. Allicin has been reported to protect against cell apoptosis induced by H2O2 in human umbilical vein endothelial cells. The present study evaluated the neuroprotective effect of allicin on the H2O2-induced apoptosis of rat pheochromocytoma PC12 cells in vitro and explored the underlying mechanism involved. PC12 cells were incubated with increasing concentrations of allicin and the toxic effect of allicin was measured by MTT assay...
September 2017: Experimental and Therapeutic Medicine
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