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Allicin

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https://www.readbyqxmd.com/read/29436625/allicin-induces-apoptosis-through-activation-of-both-intrinsic-and-extrinsic-pathways-in-glioma-cells
#1
Chenlong Li, Hanguang Jing, Guangtao Ma, Peng Liang
Allicin is an extract purified from Allium sativum (garlic), and previous research has indicated that Allicin has an inhibitory effect on many kinds of tumor cells. The aim of the present study was to explore the anticancer activity of Allicin on human glioma cells and investigate the underlying mechanism. MTT and colony-formation assays were performed to detect glioma cell proliferation, and explore the effect of Allicin at various doses and time-points. The apoptosis of glioma cells was measured by fluorescence microscopy with Hoechst 33258 staining, and then flow cytometry was used to analyzed changes in glioma cell apoptosis...
February 2, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29433241/physicochemical-characteristics-of-complexes-between-amylose-and-garlic-bioactive-components-generated-by-milling-activating-method
#2
Liming Zhang, Ping Guan, Zhihan Zhang, Yujie Dai, Limin Hao
Complexes of amylose (Am) with garlic bioactive components (GBCs) were prepared by milling activating treatment of Am and garlic paste (GP) together. The complex, produced by milling for 2.5h with the garlic (dry basis)/Am ratio of 1:5 (w/w) and water content of 25% (w/w) exhibited significantly higher allicin content (0.49mg/g of complex) than others. The scanning electron microscopy (SEM), X-ray diffraction (XRD), Fourier transforms infrared (FT-IR), differential scanning calorimetry (DSC), thermogravimetry analysis (TGA), high performance liquid chromatography (HPLC), and gas chromatography-mass spectrometry (GC-MS) techniques were used complex characterization...
March 2018: Food Research International
https://www.readbyqxmd.com/read/29429523/allicin-ameliorates-cognitive-impairment-in-app-ps1-mice-via-suppressing-oxidative-stress-by-blocking-jnk-signaling-pathways
#3
Hao Zhang, Ping Wang, Yixue Xue, Libo Liu, Zhen Li, Yunhui Liu
In middle and old age, Alzheimer's disease (AD) is a progressive neurodegenerative disorder of brain. As an increasingly aging population, AD represents a huge burden for the patients' family and the country. However, current therapeutical strategies have shown limited effectiveness. Allicin, which is the main composition of garlic, was reported to prevent the learning and memory impairment of AD mouse model. As the mechanism is not clear, in this study, we used the APP (amyloid precursor protein)/PS1 (presenilin 1) double transgenic mice, which express human mutant APP and PS1, to determine the protective effect of allicin on neurons...
February 2018: Tissue & Cell
https://www.readbyqxmd.com/read/29227665/rare-sulfur-containing-compounds-kujounins-a1-and-a2-and-allium-sulfoxide-a1-from-allium-fistulosum-kujou
#4
Masashi Fukaya, Seikou Nakamura, Ryota Nakagawa, Souichi Nakashima, Masayuki Yamashita, Hisashi Matsuda
Three sulfur-containing compounds, kujounins A1 (1) and A2 (2) and allium sulfoxide A1 (3), were isolated from the acetone extract of Allium fistulosum 'Kujou'. Their chemical structures were elucidated on the basis of physicochemical evidence, including X-ray crystallographic data. Compounds 1 and 2 possess three rings and an acetal structure and were obtained as complex compounds having disulfide and monosaccharide moieties. On the other hand, compound 3 has a thiolane skeleton derived from allicin. Naturally occurring compounds 1-3 have rare molecular skeletons...
December 11, 2017: Organic Letters
https://www.readbyqxmd.com/read/29182588/fluorinated-analog-nmr-s-of-organosulfur-compounds-from-garlic-allium-sativum-synthesis-chemistry-and-anti-angiogenesis-and-antithrombotic-studies
#5
Eric Block, Benjamin Bechand, Sivaji Gundala, Abith Vattekkatte, Kai Wang, Shaymaa S Mousa, Kavitha Godugu, Murat Yalcin, Shaker A Mousa
We describe the synthesis, reactivity, and antithrombotic and anti-angiogenesis activity of difluoroallicin (S-(2-fluoroallyl) 2-fluoroprop-2-ene-1-sulfinothioate) and S-2-fluoro-2-propenyl-l-cysteine, both easily prepared from commercially available 3-chloro-2-fluoroprop-1-ene, as well as the synthesis of 1,2-bis(2-fluoroallyl)disulfane, 5-fluoro-3-(1-fluorovinyl)-3,4-dihydro-1,2-dithiin, trifluoroajoene ((E,Z)-1-(2-fluoro-3-((2-fluoroallyl)sulfinyl)prop-1-en-1-yl)-2-(2-fluoroallyl)disulfane), and a bis(2-fluoroallyl)polysulfane mixture...
November 28, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29169723/protective-effects-of-allicin-on-1-3-dcp-induced-lipid-metabolism-disorder-in-hepg2-cells
#6
Jing Lu, Bijun Cheng, Baochen Fang, Zhuoqun Meng, Yiying Zheng, Xiaochen Tian, Shuang Guan
Allicin (2-propene-1-sulfinothioic acid S-2-propenyl ester), with quite a good range of hepatoprotective and antineoplastic properties, is a functional substance from garlic (Allium sativum L.) The purpose of this study was to provide evidence that allicin could protect 1,3-DCP-induced lipid metabolism disorder in HepG2 cells. Allicin reduced the accumulation of triglycerides (TG) and total cholesterol (TC) in 1,3-DCP-induced HepG2 cells. Allicin significantly increased the phosphorylation of AMP-activated protein kinase (AMPK) and down-regulated the levels of sterol regulatory element binding protein-1 (SREBP-1) and sterol regulatory element binding protein-2 (SREBP-2) in 1,3-DCP-induced HepG2 cells...
November 20, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29155156/allicin-functionalized-locust-bean-gum-nanoparticles-for-improved-therapeutic-efficacy-an-in-silico-in-vitro-and-in-vivo-approach
#7
R S Soumya, S Sherin, K G Raghu, Annie Abraham
The field of nanotechnology has overgrown over the past few years and has even ventured into the field of medicine. The aim of the present study is to develop a novel allicin functionalized locust bean gum nanoparticle using the nanoprecipitation technique. The synthesized nanoparticles were characterized by dynamic light scattering, scanning electron microscopy and transmission electron microscopy. The characterization study revealed the nanoscale structure (∼100nm) of the prepared particles. In silico toxicology analysis were carried out to assess the drug-like properties and virtual toxicity of allicin...
November 15, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29126733/allicin-inspired-pyridyl-disulfides-as-antimicrobial-agents-for-multidrug-resistant-staphylococcus-aureus
#8
Jordan G Sheppard, Jeremy P McAleer, Pushkar Saralkar, Werner J Geldenhuys, Timothy E Long
A chemical library comprised of nineteen synthesized pyridyl disulfides that emulate the chemical reactivity of allicin (garlic) was evaluated for antimicrobial activity against a panel of pathogenic bacteria. Gram-positive species including vancomycin-intermediate and vancomycin-resistant Staphylococcus aureus (VISA, VRSA) demonstrated the highest level of susceptibility toward analogs with S-alkyl chains of 7-9 carbons in length. Further biological studies revealed that the disulfides display synergy with vancomycin against VRSA, cause dispersal of S...
January 1, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29111753/biogenic-nanostructured-porous-silicon-as-a-carrier-for-stabilization-and-delivery-of-natural-therapeutic-species
#9
Nguyen T Le, Jhansi R Kalluri, Armando Loni, Leigh T Canham, Jeffery L Coffer
Nanostructured mesoporous silicon (pSi) derived from the silicon-accumulator plant Tabasheer (Bambuseae) is demonstrated to serve as a potential carrier matrix for carrying and stabilizing naturally active, but otherwise metastable, therapeutic agents. Particularly, in this study, garlic oil containing phytochemicals (namely, allicin) that are capable of inhibiting Staphylococcus aureus (S. aureus) bacterial growth were incorporated into Tabasheer-derived porous silicon. Thermogravimetric analysis (TGA) indicated that relatively high amounts of the extract (53...
November 13, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29077629/mechanism-of-action-of-topical-garlic-on-wound-healing
#10
Minhal Alhashim, Jamie Lombardo
BACKGROUND: Allicin, the active component of garlic, has been shown to have antimicrobial and anti-inflammatory properties. Garlic has also been used historically by many cultures to heal wounds. Several animal studies have shown that garlic extracts increase the rate of wound healing and decrease the rate of infection. OBJECTIVE: Fibroblasts play a key role in wound healing. Here we hypothesize that fibroblasts are being activated by allicin, leading to more organized and rapid wound repair...
October 26, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/29056888/effect-of-garlic-supplement-in-the-management-of-type-2-diabetes-mellitus-t2dm-a-meta-analysis-of-randomized-controlled-trials
#11
Juan Wang, Xiuming Zhang, Haili Lan, Weijia Wang
The present study was designed to systematically evaluate the clinical efficacy and safety of garlic supplement in the management of type 2 diabetes mellitus (T2DM). PubMed, EMBASE, the Cochrane Library, and China National Knowledge Internet (CNKI) were searched for relevant randomized controlled trials (RCTs) by using the terms garlic and T2DM up to April 2017. The quality of included RCTs was assessed by the Cochrane tool of risk of bias, and data of outcomes were pooled by REVMAN 5.3. Clinical factors were handled by meta-regression and subgroup analysis, and risk of publication bias was explored by inverted funnel plots...
2017: Food & Nutrition Research
https://www.readbyqxmd.com/read/29038534/performance-and-consistency-of-a-fluorescence-based-high-throughput-screening-assay-for-use-in-babesia-drug-screening-in-mice
#12
Mohamed Abdo Rizk, Shimaa Abd El-Salam El-Sayed, Mahmoud AbouLaila, Rasha Eltaysh, Naoaki Yokoyama, Ikuo Igarashi
In this study, we evaluated the validity of a fluorescence-based assay using SYBR Green I (SG I) stain for screening antibabesial compounds against B. microti in mice. Two different hematocrits (HCTs; 2.5% and 5%) were used. Correlating relative fluorescence units (RFUs) with parasitemia showed significant linear relationships with R(2) values of 0.97 and 0.99 at HCTs of 2.5% and 5%, respectively. Meanwhile, the Z' factors in a high-throughput screening (HTS) assay were within the permissible limit (≥0.5) at 2...
October 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29023413/diallylthiosulfinate-allicin-a-volatile-antimicrobial-from-garlic-allium-sativum-kills-human-lung-pathogenic-bacteria-including-mdr-strains-as-a-vapor
#13
Jana Reiter, Natalja Levina, Mark van der Linden, Martin Gruhlke, Christian Martin, Alan J Slusarenko
Garlic (Allium sativum) has potent antimicrobial activity due to allicin (diallylthiosulfinate) synthesized by enzyme catalysis in damaged garlic tissues. Allicin gives crushed garlic its characteristic odor and its volatility makes it potentially useful for combating lung infections. Allicin was synthesized (>98% pure) by oxidation of diallyl disulfide by H₂O₂ using formic acid as a catalyst and the growth inhibitory effect of allicin vapor and allicin in solution to clinical isolates of lung pathogenic bacteria from the genera Pseudomonas, Streptococcus, and Staphylococcus, including multi-drug resistant (MDR) strains, was demonstrated...
October 12, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28962124/allicin-protects-against-h2o2-induced-apoptosis-of-pc12-cells-via-the-mitochondrial-pathway
#14
Runxiao Lv, Lili Du, Chunwen Lu, Jinhui Wu, Muchen Ding, Chao Wang, Ningfang Mao, Zhicai Shi
Allicin is a major bioactive ingredient of garlic and has a broad range of biological activities. Allicin has been reported to protect against cell apoptosis induced by H2O2 in human umbilical vein endothelial cells. The present study evaluated the neuroprotective effect of allicin on the H2O2-induced apoptosis of rat pheochromocytoma PC12 cells in vitro and explored the underlying mechanism involved. PC12 cells were incubated with increasing concentrations of allicin and the toxic effect of allicin was measured by MTT assay...
September 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28926934/the-beneficial-effects-of-allicin-in-chronic-kidney-disease-are-comparable-to-losartan
#15
Ehécatl Miguel Ángel García Trejo, Abraham Said Arellano Buendía, Omegar Sánchez Reyes, Fernando Enrique García Arroyo, Raúl Arguello García, María Lilia Loredo Mendoza, Edilia Tapia, Laura Gabriela Sánchez Lozada, Horacio Osorio Alonso
Recent studies suggest that allicin may play a role in chronic kidney disease (CKD), reducing hypertension and oxidative stress and improving renal dysfunction. In the present study, CKD was induced by 5/6 nephrectomy and the animals were divided into four treatment groups as follows: control (C), CKD, CKD+allicin (40 mg/kg pathway oral) (CKDA), and CKD+Losartan (20 mg/kg) (CKDL). After CKD induction, the rats developed hypertension from week 3 to the end of the study. This was associated with increased creatinine and blood urea nitrogen (BUN) levels in serum, increased albuminuria, increased urinary excretion of N-acetyl-β-d-glucosaminidase (NAG), increased nephrin expression, and incrased histological alterations in the cortex...
September 16, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28911544/black-garlic-a-critical-review-of-its-production-bioactivity-and-application
#16
REVIEW
Shunsuke Kimura, Yen-Chen Tung, Min-Hsiung Pan, Nan-Wei Su, Ying-Jang Lai, Kuan-Chen Cheng
Black garlic is obtained from fresh garlic (Allium sativum L.) that has been fermented for a period of time at a controlled high temperature (60-90°C) under controlled high humidity (80-90%). When compared with fresh garlic, black garlic does not release a strong offensive flavor owing to the reduced content of allicin. Enhanced bioactivity of black garlic compared with that of fresh garlic is attributed to its changes in physicochemical properties. Studies concerning the fundamental findings of black garlic, such as its production, bioactivity, and applications, have thus been conducted...
January 2017: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/28872080/-role-of-autophagy-in-ameliorating-sepsis-induced-acute-lung-injury-by-allicinin-in-mice
#17
Yue Peng, Yu Jiang, Hao Ou, Wei Xing, Mingshi Yang, Min Gao
To investigate roles of autophagy in ameliorating sepsis-induced acute lung injury by allicinin in mice.
 Methods: A total of 152 male Balb/c mice (8-week old) were randomly divided into a sham group, a septic model group, an allicin treatment group, and an autophagy inhibition group. Septic mouse model was established by cecal ligation and puncture (CLP). Mice in the allicin treatment group were given allicin (30 mg/kg, intra-peritoneal injection) at 6 and 12 h, while those in the autophagy inhibition group were given autophagy inhibitor 3-MA (15 mg/kg, intra-peritoneal injection) at half an hour after allicin administration...
August 28, 2017: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/28868122/allicin-attenuates-tunicamycin-induced-cognitive-deficits-in-rats-via-its-synaptic-plasticity-regulatory-activity
#18
Qiong Xiang, Xian-Hui Li, Bo Yang, Xin-Xing Fang, Jing Jia, Jie Ren, Yu-Chun Dong, Cheng Ou-Yang, Guang-Cheng Wang
OBJECTIVES: To illuminate the functional effects of allicin on rats with cognitive deficits induced by tunicamycin (TM) and the molecular mechanism of this process. MATERIALS AND METHODS: 200-250 g male SD rats were divided into three groups at random: control group (n=12), TM group (5 μl, 50 μM, ICV, n=12), and allicin treatment group (180 mg/kg/d with chow diet, n=12). After 16 weeks of allicin treatment, the learning ability and memory were tested using novel object recognition (NOR) testing on rats with 72 hr TM treatment (5 μl, 50 μM, ICV); meanwhile, the variation of field excitatory postsynaptic potential (fEPSP) in the Schaffer Collateral (SC)-CA1 synapse was detected by extracellular electrophysiological recordings and the morphology of dendritic spine was observed by Golgi staining as well as detecting several synaptic plasticity-related proteins by Western blot...
June 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28858299/synthesis-and-in-vitro-biological-evaluation-of-thiosulfinate-derivatives-for-the-treatment-of-human-multidrug-resistant-breast-cancer
#19
Ariane Roseblade, Alison Ung, Mary Bebawy
Organosulfur compounds derived from Allium vegetables have long been recognized for various therapeutic effects, including anticancer activity. Allicin, one of the main biologically active components of garlic, shows promise as an anticancer agent; however, instability makes it unsuitable for clinical application. The aim of this study was to investigate the effect of stabilized allicin derivatives on human breast cancer cells in vitro. In this study, a total of 22 stabilized thiosulfinate derivatives were synthesized and screened for their in vitro antiproliferative activities against drug-sensitive (MCF-7) and multidrug-resistant (MCF-7/Dx) human adenocarcinoma breast cancer cells...
October 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/28828709/a-comprehensive-review-on-pharmacotherapeutics-of-three-phytochemicals-curcumin-quercetin-and-allicin-in-the-treatment-of-gastric-cancer
#20
REVIEW
Atousa Haghi, Haniye Azimi, Roja Rahimi
OBJECTIVE: Gastric cancer is one of the most common causes of cancer-related death worldwide. Medicinal plants are one of the main sources for discovery of new pharmacological agents especially for treatment of cancers. The aim of the present study is to review pharmacotherapeutic aspects of three mostly studied phytochemicals including curcumin, quercetin, and allicin for management of gastric cancer. METHODS: Scopus, PubMed, Web of Science, and Google Scholar were searched for the effects of curcumin, quercetin, allicin, and their analogs in gastric cancer...
December 2017: Journal of Gastrointestinal Cancer
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