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Allicin

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https://www.readbyqxmd.com/read/27892697/allium-roseum-l-extract-exerts-potent-suppressive-activities-on-chronic-myeloid-leukemia-k562-cell-viability-through-the-inhibition-of-bcr-abl-pi3k-akt-and-erk1-2-pathways-and-the-abrogation-of-vegf-secretion
#1
Soumaya Souid, Hanen Najjaa, Ichrak Riahi-Chebbi, Meriam Haoues, Mohamed Neffati, Ingrid Arnault, Jacques Auger, Habib Karoui, Makram Essafi, Khadija Essafi-Benkhadir
Use of plant extracts, alone or combined to the current chemotherapy as chemosensitizers, has emerged as a promising strategy to overcome tumor drug resistance. Here, we investigated the anticancer activity of Allium roseum L. extracts, a wild edible species in North Africa, on human Chronic Myeloid Leukemia (CML) K562 cells. The dehydrated aqueous extract (DAE) disturbed the cell cycle progression and induced the apoptosis of K562 cells. Chemical analysis of DAE showed a diversity of organosulfur compounds S-alk(en)yl-cysteine sulfoxides (RCSO) and high amount of allicin, suggesting that such molecule may be behind its antitumor effect...
November 28, 2016: Nutrition and Cancer
https://www.readbyqxmd.com/read/27868250/effects-of-astragalus-membranaceus-codonopsis-pilosula-and-allicin-mixture-on-growth-performance-nutrient-digestibility-faecal-microbial-shedding-immune-response-and-meat-quality-in-finishing-pigs
#2
R X Lan, J W Park, D W Lee, I H Kim
A 12-week trial with 120 [(Landrace×Yorkshire)×Duroc] pigs (45.65 ± 1.93 kg) was conducted to evaluate the effects of Astragalus membranaceus, Codonopsis pilosula and allicin mixture (HM) supplementation on growth performance, nutrient digestibility, faecal microbial shedding, immune response and meat quality in finishing pigs. Pigs were allocated to one of three treatments with 0, 0.025% (HM1) and 0.05% (HM2) HM supplementation in a randomized complete block design according to sex and BW. Each treatment contained 10 replications with four pigs (two barrows and two gilts) per pen...
November 21, 2016: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/27855892/cooked-garlic-and-antioxidant-activity-correlation-with-organosulfur-compound-composition
#3
D A Locatelli, M A Nazareno, C M Fusari, A B Camargo
The antioxidant properties and the main beneficial organosulphur compounds of home-cooked garlic samples were studied in order to establish relationships between them. Antioxidant activity was tested by free radical scavenging against 2,2-diphenyl-1-picrylhydrazyl radical (DPPH) and 2,2'-azino-bis-(3-ethylbenzo-thiazoline-6-sulfonic acid) diammonium salt (ABTS(+)), Fe(III) reducing ability (FRAP) and linoleic acid co-oxidation initiated by soybean lipoxygenase in a micelle system. DPPH, ABTS and FRAP assays showed the highest activity for raw garlic samples, while β-carotene bleaching assay yielded the highest activity for stir-fried garlic...
January 0: Food Chemistry
https://www.readbyqxmd.com/read/27765964/properties-and-storage-stability-of-whey-protein-edible-film-with-spice-powders
#4
Apisada Ket-On, Natkritta Pongmongkol, Anongnat Somwangthanaroj, Theeranun Janjarasskul, Kanitha Tananuwong
The impact of spice powders on physical, mechanical, thermal and barrier properties, and on storage stability, of whey protein isolate (WPI)-based films was determined. Films with added spices were prepared from casting solution containing 10 % (w/w) heat-denatured WPI, glycerol (WPI:glycerol of 3:2 w/w), sodium chloride (0.4 g/100 g solution), garlic and pepper powders (≤3 g each/100 g solution). Water activity (aw) of all films was 0.53-0.57. Addition of spice powders increased thickness, darkness and yellowness of the WPI films...
July 2016: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/27756563/allicin-inspired-thiolated-fluoroquinolones-as-antibacterials-against-eskape-pathogens
#5
Jordan G Sheppard, Timothy E Long
Thiolated fluoroquinolones were synthesized from ciprofloxacin and evaluated for antimicrobial activity against a panel of pathogenic bacteria. Gram-positive species including methicillin-resistant Staphylococcus aureus (MRSA) exhibited the highest level of increased sensitivity toward ciprofloxacin bound with a N-propylthio substituent. Evidence was found that the antibiotics form disulfides with low molecular weight thiols in bacteria and potentiate generation of cytosolic reactive oxygen species (ROS). In final analysis, the enhanced anti-MRSA activity of thiolated fluoroquinolones was attributed to increased cell permeability and reaction with cytosolic thiols that yields an inactive disulfide metabolite and the parent drug ciprofloxacin as an inhibitor of DNA synthesis...
October 4, 2016: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/27725449/evaluation-of-the-effects-of-s-allyl-l-cysteine-s-methyl-l-cysteine-trans-s-1-propenyl-l-cysteine-and-their-n-acetylated-and-s-oxidized-metabolites-on-human-cyp-activities
#6
Hirotaka Amano, Daichi Kazamori, Kenji Itoh
Three major organosulfur compounds of aged garlic extract, S-allyl-L-cysteine (SAC), S-methyl-L-cysteine (SMC), and trans-S-1-propenyl-L-cysteine (S1PC), were examined for their effects on the activities of five major isoforms of human CYP enzymes: CYP1A2, 2C9, 2C19, 2D6, and 3A4. The metabolite formation from probe substrates for the CYP isoforms was examined in human liver microsomes in the presence of organosulfur compounds at 0.01-1 mM by using liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis...
2016: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/27723197/therapeutic-hotline-oral-allicin-in-the-treatment-of-behcet-s-disease-through-attenuating-oxidative-stress-a-pilot-study-in-20-patients-with-mucocutaneous-lesions
#7
Jianqiao Zhong, Dehai Xian, Xia Xiong, Junxiang Liu
Behçet's disease (BD) involves oxidative stress (OS) aggression and imbalanced oxidant/antioxidant status. Owing to its antioxidant property, allicin is proposed for treating BD. In this study, we aimed to investigate the efficacy and safety of allicin on patients with BD with mucocutaneous involvement. Twenty patients with active BD were treated with allicin for 12 weeks and followed up to 16 weeks. A clinical manifestations index and scoring system was the primary technique for efficacy evaluation at baseline and Week 4, 12, 16...
October 9, 2016: Dermatologic Therapy
https://www.readbyqxmd.com/read/27712876/allicin-ameliorates-intraintestinal-bacterial-translocation-after-trauma-hemorrhagic-shock-in-rats-the-role-of-mesenteric-lymph-node-dendritic-cell
#8
Yun Zhang, Jian Zhang, Tao Xu, Wei Wu, Fang-Fang Huang, Wen-Qiao Yu, Shao-Yang Zhang, Ting-Bo Liang
BACKGROUND: Intestinal dendritic cells play important roles in regulating the function of the intestinal immune barrier and the intestinal bacterial translocation. In this study, we aim to investigate the effects of allicin on the function of mesenteric lymph node-dendritic cells after trauma/hemorrhagic shock. METHODS: One hundred and eight-four Sprague-Dawley rats were randomly assigned into a sham group (n = 46), sham + allicin group (n = 46), trauma/hemorrhagic shock group (n = 46), and trauma/hemorrhagic shock + allicin group (n = 46)...
October 3, 2016: Surgery
https://www.readbyqxmd.com/read/27664612/salting-out-extraction-of-allicin-from-garlic-allium-sativum-l-based-on-ethanol-ammonium-sulfate-in-laboratory-and-pilot-scale
#9
Fenfang Li, Qiao Li, Shuanggen Wu, Zhijian Tan
Salting-out extraction (SOE) based on lower molecular organic solvent and inorganic salt was considered as a good substitute for conventional polymers aqueous two-phase extraction (ATPE) used for the extraction of some bioactive compounds from natural plants resources. In this study, the ethanol/ammonium sulfate was screened as the optimal SOE system for the extraction and preliminary purification of allicin from garlic. Response surface methodology (RSM) was developed to optimize the major conditions. The maximum extraction efficiency of 94...
February 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27610111/garlic-from-remedy-to-stimulant-evaluation-of-antifungal-potential-reveals-diversity-in-phytoalexin-allicin-content-among-garlic-cultivars-allicin-containing-aqueous-garlic-extracts-trigger-antioxidants-in-cucumber
#10
Sikandar Hayat, Zhihui Cheng, Husain Ahmad, Muhammad Ali, Xuejin Chen, Mengyi Wang
Garlic has the charisma of a potent remedy and holds its repute of a therapeutic panacea since the dawn of civilization. An integrated approach was adopted to evaluate the genetic diversity among Chinese garlic cultivars for their antifungal potency as well as allicin content distribution and, furthermore; a bioassay was performed to study the bio-stimulation mechanism of aqueous garlic extracts (AGE) in the growth and physiology of cucumber (Cucumis sativus). Initially, 28 garlic cultivars were evaluated against four kinds of phytopathogenic fungi; Fusarium oxysporum, Botrytis cinerea, Verticillium dahliae and Phytophthora capsici, respectively...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27596067/allicin-ameliorates-kidney-function-and-urinary-bladder-sensitivity-in-cyclosporine-a-treated-rats
#11
D H El-Kashef, A E El-Kenawi, G M Suddek, H A Salem
Cyclosporine-A (CsA) is an immunosuppressive drug which has been used to prevent rejection after organ transplantation and to treat certain autoimmune diseases. However, its therapeutic use is limited by nephrotoxicity. In this study, the modulator effect of allicin on the oxidative nephrotoxicity of CsA in rats was investigated. Furthermore, the effect of allicin on CsA-induced hypersensitivity of urinary bladder rings to acetylcholine (ACh) was estimated. Rats were divided into three groups, control, CsA (15 mg/kg, subcutaneously), and CsA/allicin (50 mg/kg, orally)...
September 5, 2016: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/27584700/diet-supplementation-with-allicin-protects-against-alcoholic-fatty-liver-disease-in-mice-by-improving-anti-inflammation-and-antioxidative-functions
#12
Suraphan Panyod, Wei-Kai Wu, Chi-Tang Ho, Kuan-Hung Lu, Chun-Ting Liu, Yung-Lin Chu, Yi-Syuan Lai, Wei-Cheng Chen, Yu-En Lin, Shih-Hang Lin, Lee-Yan Sheen
This study investigated the liver-protective effects of allicin, an active compound in fresh garlic, against alcoholic fatty liver disease (AFLD) and liver inflammation. Its effects were investigated in an AFLD model in male C57BL/6 mice, which were fed Lieber-DeCarli liquid diet containing ethanol. Allicin (5 and 20 mg/kg bw/day) was orally administered daily in the AFLD mice for 4 weeks. The results indicate that allicin promotes hepatoprotection by significantly reducing aspartate transaminase (AST) and alanine transaminase (ALT) levels (p < 0...
September 28, 2016: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/27573340/allicin-protects-traumatic-spinal-cord-injury-through-regulating-the-hsp70-akt-inos-pathway-in-mice
#13
Shunyi Wang, Dongliang Ren
Allicin is a major component of garlic, extracted as an oily liquid. The present study was designed to investigate the beneficial effects of allicin on traumatic spinal cord injury (TSCI) in mice, and whether the effects are mediated via regulation of the heat shock protein 70 (HSP70), v‑akt murine thymoma viral oncogene homolog 1 (Akt) and inducible nitric oxide synthase (iNOS) pathways. Adult BALB/c mice (30‑40 g) received a laminectomy at the T9 vertebral level as a model of TSCI. In the present study, treatment of the TSCI mice with allicin significantly increased their Basso, Beattie and Bresnahan (BBB) scores (P<0...
October 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27561292/activation-of-the-nrf2-signaling-pathway-involving-klf9-plays-a-critical-role-in-allicin-resisting-against-arsenic-trioxide-induced-hepatotoxicity-in-rats
#14
Daqian Yang, Zhanjun Lv, Haili Zhang, Biying Liu, Huijie Jiang, Xiao Tan, Jingjing Lu, Ruiqi Baiyun, Zhigang Zhang
Arsenic trioxide (As2O3) is both the most prevalent, naturally occurring inorganic arsenical threatening human health and an efficient therapeutic for acute promyelocytic leukemia. Regretfully, As2O3-treated cancer patients often suffer from hepatotoxicity. While effective antioxidant and anticarcinogenic actions of allicin have previously been demonstrated, studies indicating how allicin affects As2O3-induced hepatotoxicity and arsenic accumulation are lacking. Our study, for the first time, elaborates potential details of the hepatoprotective mechanisms of allicin against As2O3-induced liver injury...
August 25, 2016: Biological Trace Element Research
https://www.readbyqxmd.com/read/27542503/development-of-garlic-bioactive-compounds-analytical-methodology-based-on-liquid-phase-microextraction-using-response-surface-design-implications-for-dual-analysis-cooked-and-biological-fluids-samples
#15
Daniela Andrea Ramirez, Daniela Ana Locatelli, Carolina Andrea Torres-Palazzolo, Jorgelina Cecilia Altamirano, Alejandra Beatriz Camargo
Organosulphur compounds (OSCs) present in garlic (Allium sativum L.) are responsible of several biological properties. Functional foods researches indicate the importance of quantifying these compounds in food matrices and biological fluids. For this purpose, this paper introduces a novel methodology based on dispersive liquid-liquid microextraction (DLLME) coupled to high performance liquid chromatography with ultraviolet detector (HPLC-UV) for the extraction and determination of organosulphur compounds in different matrices...
January 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27537199/anti-leishmanial-activity-in-vitro-and-in-vivo-of-allicin-and-allicin-cream-using-leishmania-major-sub-strain-zymowme-lon4-and-balb-c-mice
#16
Dina M Metwally, Ebtesam M Al-Olayan, Manal F El-Khadragy, Badriah Alkathiri
BACKGROUND: Leishmania is a unicellular protozoan parasite that produces several human diseases, ranging from localized self-healing cutaneous lesions to deadly visceral infections. OBJECTIVE: The effect of allicin on the growth of Leishmania major (L. major) promastigotes was evaluated under in vitro conditions. Moreover, the efficacy of a topical allicin cream was examined in BALB/c (Bagg albino, laboratory-bred strain of the House Mouse) mice with cutaneous leishmanial lesions compared to the currently used drug, sodiumstibogluconate (pentostam)...
2016: PloS One
https://www.readbyqxmd.com/read/27516650/a-comparative-study-of-allium-hirtifolium-in-traditional-and-modern-medicine
#17
Laleh Zaheri Abdehvand, Samaneh Soleymani
BACKGROUND: Shallots (wild garlic/Osghordion) with the scientific name of Allium hertifolium, is one of the most famous plants from the Alliaceae family. For a long time, shallots have been used as a source of food and medicine in Iran. The active ingredients of the plant could be referred to agapentagenin, allicin, omega-3, omega-6, and minerals such as potassium, sodium, magnesium, iron, copper, zinc, and manganese. This study was conducted to compare shallots in the traditional and modern medicine in order to make a better use of this precious plant...
May 2016: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/27412589/allicin-improves-the-cardiac-function-by-protecting-against-apoptosis-in-rat-model-of-myocardial-infarction
#18
Li-Na Ma, Lian-da Li, Shao-Chun Li, Xin-Mei Hao, Jin-Yan Zhang, Ping He, Yi-Kui Li
OBJECTIVE: To study the effects of allicin on cardiac function and underlying mechanism in rat model of myocardial infarction (MI). METHODS: Ninety-four Wistar rats were randomly assigned to 6 groups (n =14-16 per group): sham control group [underwent thoracotomy without left anterior descending (LAD) occlusion and only received an injection of the same amount of citrate buffer], MI control group (subjected to LAD occlusion and only received an injection of same amount of citrate buffer), positive control group (subjected to LAD occlusion and received an injection of diltiazem hydrochloride at the dose of 1...
July 13, 2016: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/27367677/subinhibitory-concentrations-of-allicin-decrease-uropathogenic-escherichia-coli-upec-biofilm-formation-adhesion-ability-and-swimming-motility
#19
Xiaolong Yang, Kaihui Sha, Guangya Xu, Hanwen Tian, Xiaoying Wang, Shanze Chen, Yi Wang, Jingyu Li, Junli Chen, Ning Huang
Uropathogenic Escherichia coli (UPEC) biofilm formation enables the organism to avoid the host immune system, resist antibiotics, and provide a reservoir for persistent infection. Once the biofilm is established, eradication of the infection becomes difficult. Therefore, strategies against UPEC biofilm are urgently required. In this study, we investigated the effect of allicin, isolated from garlic essential oil, on UPEC CFT073 and J96 biofilm formation and dispersal, along with its effect on UPEC adhesion ability and swimming motility...
2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27363537/protective-effects-of-allicin-on-streptozotocin-induced-diabetic-nephropathy-in-rats
#20
Hong Huang, Ying Jiang, Genxiang Mao, Fang Yuan, Hexin Zheng, Yuan Ruan, Tianfeng Wu
BACKGROUND: Studies in animal models have showed that allicin, a major biologically active component of garlic, can play a role in the prevention of tissue fibrosis in liver, lung and heart, mainly related to the inhibition of fibroblast proliferation, fibrogenic cytokine secretion and extracellular matrix synthesis. This study aimed to investigate the protective effects of allicin, on the damage of renal in streptozotocin (STZ)-induced diabetic rats. STZ-induced diabetic rats were administered allicin (15, 30 , 45 mg · kg(-1)  · d(-1) , respectively) via daily intra-gastric gavage for 12weeks...
July 1, 2016: Journal of the Science of Food and Agriculture
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