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https://www.readbyqxmd.com/read/28816176/-severely-increased-serum-lipid-levels-in-diabetic-ketoacidosis-case-report
#1
Hrafnkell Stefansson, Kristinn Sigvaldason, Hilmar Kjartansson, Helga Águsta Sigurjonsdottir
Severe hypertriglyceridemia is a known, but uncommon complication of diabetic ketoacidosis. We discuss the case of a 23-year-old, previously healthy, woman who initially presented to the emergency department with abdominal pain. Grossly lipemic serum due to extremely high triglyceride (38.6 mmol/L) and cholesterol (23.2 mmol/L) levels were observed with a high blood glucose (23 mmol/L) and a low pH of 7.06 on a venous blood gas. She was treated successfully with fluids and insulin and had no sequale of pancreatitis or cerebral edema...
July 2017: Læknablađiđ
https://www.readbyqxmd.com/read/28815763/does-low-energy-collision-induced-dissociation-of-lithiated-and-sodiated-carbohydrates-always-occur-at-anomeric-carbon-of-reducing-end
#2
Shang-Ting Tsai, Jien-Lian Chen, Chi-Kung Ni
RATIONALE: Collision-induced dissociation (CID) tandem mass spectrometry is one of the major methods in the structural determination of carbohydrates. Previous experimental studies and theoretical investigation of lithiated and sodiated underivatized carbohydrates seem to indicate that dehydration reaction and cross ring dissociation of low-energy CID mainly occur at the anomeric carbon of reducing end. However, these studies only investigated few carbohydrates. METHODS: ESI-MS/MS spectra of [M+Li](+) and [M+Na](+) ions of several (18) O1-labeled monosaccharides and disaccharides at O1 of reducing end were studied using linear ion trap mass spectrometer...
August 16, 2017: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/28814973/photoautotrophic-production-of-polyhydroxyalkanoates-in-a-synthetic-mixed-culture-of-synechococcus-elongatus-cscb-and-pseudomonas-putida-cscab
#3
Hannes Löwe, Karina Hobmeier, Manuel Moos, Andreas Kremling, Katharina Pflüger-Grau
BACKGROUND: One of the major challenges for the present and future generations is to find suitable substitutes for the fossil resources we rely on today. Cyanobacterial carbohydrates have been discussed as an emerging renewable feedstock in industrial biotechnology for the production of fuels and chemicals, showing promising production rates when compared to crop-based feedstock. However, intrinsic capacities of cyanobacteria to produce biotechnological compounds are limited and yields are low...
2017: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/28814394/dynamics-of-intrapericardial-and-extrapericardial-fat-tissues-during-long-term-dietary-induced-moderate-weight-loss
#4
Gal Tsaban, Arik Wolak, Hila Avni-Hassid, Yftach Gepner, Ilan Shelef, Yaakov Henkin, Dan Schwarzfuchs, Noa Cohen, Nitzan Bril, Michal Rein, Dana Serfaty, Shira Kenigsbuch, Lilac Tene, Hila Zelicha, Anat Yaskolka-Meir, Oded Komy, Avital Bilitzky, Yoash Chassidim, Uta Ceglarek, Michael Stumvoll, Matthias Blüher, Joachim Thiery, Dror Dicker, Assaf Rudich, Meir J Stampfer, Iris Shai
Background: In view of evidence linking pericardial fat accumulation with increased cardiovascular disease risk, strategies to reduce its burden are needed. Data comparing the effects of specific long-term dietary interventions on pericardial fat tissue mobilization are sparse.Objective: We sought to evaluate intrapericardial-fat (IPF) and extrapericardial-fat (EPF) changes during weight-loss interventions by different dietary regimens.Design: During 18 mo of a randomized controlled trial, we compared a Mediterranean/low-carbohydrate (MED/LC) diet plus 28 g walnuts/d with a calorically equal low-fat (LF) diet among randomly assigned participants with moderate abdominal obesity...
August 16, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28812446/higher-dietary-intake-of-vitamin-d-may-influence-total-cholesterol-and-carbohydrate-profile-independent-of-body-composition-in-men-with-chronic-spinal-cord-injury
#5
Christopher Beal, Ashraf Gorgey, Pamela Moore, Nathan Wong, Robert A Adler, David Gater
STUDY DESIGN: A case-control design. OBJECTIVES: To determine the effects of dietary vitamin D intake on insulin sensitivity (Si), glucose effectiveness (Sg), and lipid profile in individuals with spinal cord injury (SCI). METHODS: 20 male, paraplegic (T3-L1) with chronic (> one year) motor complete SCI (AIS A or B) were recruited. Three-day dietary records were analyzed for dietary vitamin D (calciferol), and participants were assigned to one of two groups, a high vitamin D intake group and a low vitamin D intake group based on the mid-point of vitamin D frequency distribution...
August 16, 2017: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/28811499/the-role-of-dermcidin-isoform-2-in-the-occurrence-and-severity-of-diabetes
#6
Suman Bhattacharya, Md Mobidullah Khan, Chandradipa Ghosh, Sarbashri Bank, Smarajit Maiti
Diabetes is now epidemic worldwide. Several hundred-million peoples are presently suffering from this disease with other secondary-disorders. Stress, hypertension, sedentary life-style, carbohydrate/lipid metabolic-disorders due to genetic or environmental factors attributes to type-1 and/or type-2 diabetes. Present investigation demonstrates that stress-induced protein dermcidin isoform-2 (DCN-2) which appears in the serum of diabetic-patients play a key-role in this disease pathogenesis/severity. DCN-2 suppresses insulin production-release from liver/pancreas...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28810659/hyaluronic-acid-conjugation-facilitates-clearance-of-intracellular-bacterial-infections-by-streptomycin-with-neglectable-nephrotoxicity
#7
Yuanhao Qiu, Yilin Hou, Feifei Sun, Peng Chen, Dongdong Wang, Haibo Mu, Xiaoli Zhang, Kan Ding, Jinyou Duan
Antibiotics such as β-lactams and aminoglycosides are often subtherapeutic to intracellular infections due to their high hydrophilicity, resulting in low effectiveness against intracellular pathogens and the emergence of antibiotic resistance. Here we reported that an endogenous aminoglycan, hyaluronic acid could be an effective carbohydrate carrier of the aminoglycoside antibiotic, streptomycin against intracellular pathogens. This conjugation could enhance phagocytic activity, and facilitated the entry of streptomycin into host cells via a CD44-mediated pathway...
September 1, 2017: Glycobiology
https://www.readbyqxmd.com/read/28809383/increasing-symptoms-in-irritable-bowel-symptoms-with-ingestion-of-galacto-oligosaccharides-are-mitigated-by-%C3%AE-galactosidase-treatment
#8
C J Tuck, K M Taylor, P R Gibson, J S Barrett, J G Muir
OBJECTIVES: Galacto-oligosaccharides (GOS) are dietary FODMAPs (fermentable carbohydrates) associated with triggering gastrointestinal symptoms in patients with irritable bowel syndrome (IBS). This randomized, double-blind, placebo-controlled, cross-over trial aimed to assess whether oral α-galactosidase co-ingestion with foods high in GOS and low in other FODMAPs would reduce symptoms. METHODS: Patients meeting the Rome III criteria for IBS who were hydrogen-producers on breath testing were recruited...
August 15, 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28808731/biomacromolecules-as-tools-and-objects-in-nanometrology-current-challenges-and-perspectives
#9
Payam Hashemi, Luise Luckau, Petra Mischnick, Sarah Schmidt, Rainer Stosch, Bettina Wünsch
Nucleic acids, proteins, and polysaccharides are the most important classes of biopolymers. The inherent properties of biomacromolecules are contrary to those of well-defined small molecules consequently raising a number of specific challenges which become particularly apparent if biomacromolecules are treated as objects in quantitative analysis. At the same time, their specific functional ability of molecular recognition and self-organization (e.g., enzymes, antibodies, DNA) enables us to make biomacromolecules serving as molecular tools in biochemistry and molecular biology, or as precisely controllable dimensional platforms for nanometrological applications...
August 14, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28807307/significance-of-anti-carla-salivary-iga-antibody-in-first-grazing-season-cattle-naturally-infected-with-gastrointestinal-nematodes
#10
Aurélie Merlin, Richard Shaw, Alain Chauvin, Nathalie Bareille, Christophe Chartier
A carbohydrate larval surface antigen (CarLA) present on infective larvae of all trichostrongylid nematodes is a target antigen for host immunoglobulins (Ig). Levels of anti-CarLA salivary IgA antibody (CarLA-IgA) have been shown to be correlated to the level of protective immunity to GIN in sheep and deer but no information is available in cattle. The first objective of this study was to assess the pattern of CarLA-IgA response in 7 groups (G1-G7) of first grazing season cattle (FGSC) naturally infected with gastrointestinal nematodes...
August 30, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28806407/low-fermentable-oligosaccharides-disaccharides-monosaccharides-and-polyols-fodmap-diet-improves-symptoms-in-adults-suffering-from-irritable-bowel-syndrome-ibs-compared-to-standard-ibs-diet-a-meta-analysis-of-clinical-studies
#11
Péter Varjú, Nelli Farkas, Péter Hegyi, András Garami, Imre Szabó, Anita Illés, Margit Solymár, Áron Vincze, Márta Balaskó, Gabriella Pár, Judit Bajor, Ákos Szűcs, Orsolya Huszár, Dániel Pécsi, József Czimmer
BACKGROUND: Irritable bowel syndrome (IBS) and functional digestive tract disorders, e.g. functional bloating, carbohydrate maldigestion and intolerances, are very common disorders frequently causing significant symptoms that challenge health care systems. A low Fermentable Oligosaccharides, Disaccharides, Monosaccharides and Polyols (FODMAP) diet is one of the possible therapeutic approaches for decreasing abdominal symptoms and improving quality of life. OBJECTIVES: We aimed to meta-analyze data on the therapeutic effect of a low-FODMAP diet on symptoms of IBS and quality of life and compare its effectiveness to a regular, standard IBS diet with high FODMAP content, using a common scoring system, the IBS Symptom Severity Score (IBS-SSS)...
2017: PloS One
https://www.readbyqxmd.com/read/28805274/quantitative-characterization-of-galectin-3-c-affinity-mass-spectrometry-measurements-comprehensive-data-analysis-obstacles-shortcuts-and-robustness
#12
Marko Haramija, Jasna Peter-Katalinić
RATIONALE: Affinity mass spectrometry (AMS) is an emerging tool in the field of study of protein-carbohydrate complexes. However, experimental obstacles and data analysis is preventing faster integration of AMS methods in the field of glycosciences. Here we show how analysis of direct ESI-MS AMS data can be simplified for screening purposes, even for complex AMS spectra. METHODS: Direct ESI-MS assay was tested in this study, and binding data for the galectin-3C•lactose complex were analyzed using comprehensive and simplified data analysis approach...
August 14, 2017: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/28803105/glucose-bioconversion-profile-in-the-syngas-metabolizing-species-clostridium-carboxidivorans
#13
Ánxela Fernández-Naveira, María C Veiga, Christian Kennes
Some clostridia produce alcohols (ethanol, butanol, hexanol) from gases (CO, CO2, H2) and others from carbohydrates (e.g., glucose). C. carboxidivorans can metabolize both gases as well as glucose. However, its bioconversion profile on glucose had not been reported. It was observed that C. carboxidivorans does not follow a typical solventogenic stage when grown on glucose. Indeed, at pH 6.2, it produced first a broad range of acids (acetic, butyric, hexanoic, formic, and lactic acids), several of which are generally not found, under similar conditions, during gas fermentation...
August 2, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28800397/association-between-the-7-day-moving-average-for-nutrition-and-growth-in-very-low-birth-weight-infants
#14
Gustave H Falciglia, Karna Murthy, Jane Holl, Hannah L Palac, Yuliya Oumarbaeva, Pratyusha Yadavalli, Donna Woods, Daniel T Robinson
BACKGROUND: Very low birth weight (VLBW) infants remain at risk for postnatal growth restriction. Clinicians may have difficulty identifying growth patterns resulting from nutrition interventions, impeding prompt management changes intended to increase growth velocity. This study aimed to quantify the association between growth and nutrition intake through 7-day moving averages (SDMAs). METHODS: The first 6 weeks of daily nutrition intake and growth measurements were collected from VLBW infants admitted to a level 4 neonatal intensive care unit (2011-2014)...
August 1, 2017: JPEN. Journal of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28799896/neurosecretory-protein-gl-stimulates-food-intake-de-novo-lipogenesis-and-onset-of-obesity
#15
Eiko Iwakoshi-Ukena, Kenshiro Shikano, Kunihiro Kondo, Shusuke Taniuchi, Megumi Furumitsu, Yuta Ochi, Tsutomu Sasaki, Shiki Okamoto, George E Bentley, Lance J Kriegsfeld, Yasuhiko Minokoshi, Kazuyoshi Ukena
Mechanisms underlying the central regulation of food intake and fat accumulation are not fully understood. We found that neurosecretory protein GL (NPGL), a newly-identified neuropeptide, increased food intake and white adipose tissue (WAT) in rats. NPGL-precursor gene overexpression in the hypothalamus caused increases in food intake, WAT, body mass, and circulating insulin when fed a high calorie diet. Intracerebroventricular administration of NPGL induced de novo lipogenesis in WAT, increased insulin, and it selectively induced carbohydrate intake...
August 11, 2017: ELife
https://www.readbyqxmd.com/read/28799845/how-does-young-women-s-weight-perception-affect-their-nutrient-intake-korean-young-women-s-dietary-consumption-and-nutritional-deficiency
#16
Seonglim Lee, Jaehye Suk, Minjeong Kim, Hyesun Hwang
We investigated the relationship between Korean young women's weight perception and nutritional deficiency to understand the effect of culturally fostered ideals of women's bodies on dietary life. We analyzed 585 participants' responses from the 2011 Korea National Health and Nutrition Examination Survey by using logistic regressions. Women who overestimated their weight were more likely to suffer from nutritional deficiency. Overestimating weight was significantly associated with increased relative risks of deficient carbohydrate and protein intake...
August 11, 2017: Health Care for Women International
https://www.readbyqxmd.com/read/28795344/backbone-and-side-chain-assignments-for-a-novel-cbm69-starch-binding-domain-amyp-sbd
#17
Xinxin Li, Jigang Yu, Jiahai Zhang, Hongbin Sun, Xuecheng Zhang
Starch binding domains (SBDs) are important for the functions of glycoside hydrolysis enzymes such as α-amylases, they have great application potential in biotechnology and industries. AmyP is a newly identified α-amylase belonging to a new subfamily 37 of glycoside hydrolysis enzyme family 13. AmyP shows preferential degradation to soluble starch, in which its C-terminal starch binding domain, AmyP-SBD, plays an important role. AmyP-SBD shares very low sequence similarity with other biochemically characterized SBDs and was assigned to a new carbohydrate binding module family CBM69...
August 9, 2017: Biomolecular NMR Assignments
https://www.readbyqxmd.com/read/28794212/addition-of-rye-bran-and-pea-fiber-to-pork-meatballs-enhances-subjective-satiety-in-healthy-men-but-does-not-change-glycemic-or-hormonal-responses-a-randomized-crossover-meal-test-study
#18
Ursula Kehlet, Josephine Kofod, Jens J Holst, Christian Ritz, Margit D Aaslyng, Anne Raben
Background: The development of high-protein, fiber-rich foods targeting appetite control could be an efficient tool in obesity prevention.Objectives: We investigated whether ad libitum energy intake (EI), appetite, and metabolic markers in a meal context were affected by 1) fiber addition (rye bran and pea fiber) to pork meatballs, 2) the food matrix of the fiber (fiber meatballs compared with fiber bread), or 3) the protein source (animal compared with vegetable protein patties).Methods: In a crossover design, 40 healthy men [mean ± SD: body mass index (BMI; in kg/m(2)), 22...
August 9, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28793772/effect-of-dietary-lipids-on-endotoxemia-influences-postprandial-inflammatory-response
#19
Javier Lopez-Moreno, Sonia García-Carpintero, Rosa Jimenez-Lucena, Carmen Haro, Oriol A Rangel-Zúñiga, Ruth Blanco-Rojo, Elena Maria Yubero-Serrano, Francisco J Tinahones, Javier Delgado-Lista, Pablo Pérez-Martínez, Helen M Roche, Jose Lopez-Miranda, Antonio Camargo
Metabolic syndrome (MetS) results in postprandial metabolic alterations that predisposes to a state of chronic low-grade inflammation and increased oxidative stress. We aimed to assess the effect of the consumption of the quantity and quality of dietary fat on fasting and postprandial plasma lipopolysaccharides (LPS). A subgroup of 75 subjects with metabolic syndrome was randomized to receive 1 of 4 diets: HSFA, rich in saturated fat; HMUFA, rich in monounsaturated fat; LFHCC n-3, low-fat, rich in complex carbohydrate diet supplemented with n-3 polyunsaturated fatty acids; LFHCC low-fat, rich in complex carbohydrate diet supplemented with placebo, for 12 week each...
August 9, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28793331/characterization-of-the-post-prandial-insulinemic-response-and-low-glycaemic-index-of-a-soy-beverage
#20
Jose Ce Serrano, Meritxell Martín-Gari, Anna Cassanye, Ana Belen Granado-Serrano, Manuel Portero-Otín
Soybean is recognized as rich source of bioactive compounds for the improvement of glucose homeostasis. However, the post-prandial mechanisms of action have not been extensively described. The aim of this study is to determine the changes in glucose homeostasis and related factors after acute intake of a soy beverage. Twenty-nine subjects (15 women and 14 men, with an average age of 19.5 ± 1.2) ingested 500 mL of water, glucose (20.5 g/500 mL) and soy beverage (20 g of carbohydrate) in three separate sessions...
2017: PloS One
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