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https://www.readbyqxmd.com/read/27896774/multiplex-measurement-of-serum-folate-vitamers-by-uplc-ms-ms
#1
Sarah Meadows
The implementation of a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method to measure six folate vitamers in serum samples allows a more individual and accurate measurement than the commonly used immunoassays. In the described method, serum samples undergo solid phase extraction followed by liquid chromatography coupled with electrospray ionization tandem mass spectrometry with a run time of 3.5 min. Recovery is 95 % for the most important folate metabolite, 5-methyltetrahydrofolate (MTHF), and greater than 78 % for other minor folate forms...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27863073/catalytic-transfer-hydrogenation-of-furfural-to-2-methylfuran-and-2-methyltetrahydrofuran-over-bimetallic-copper-palladium-catalysts
#2
Xin Chang, An-Feng Liu, Bo Cai, Jin-Yue Luo, Hui Pan, Yao-Bing Huang
The catalytic transfer hydrogenation of furfural to the fuel additives 2-methylfuran (2-MF) and 2-methyltetrahydrofuran (2-MTHF) was investigated over various bimetallic catalysts in the presence of the hydrogen donor 2-propanol. Of all the as-prepared catalysts, bimetallic Cu-Pd catalysts showed the highest catalytic activities towards the formation of 2-MF and 2-MTHF with a total yield of up to 83.9 % yield at 220 °C in 4 h. By modifying the Pd ratios in the Cu-Pd catalyst, 2-MF or 2-MTHF could be obtained selectively as the prevailing product...
November 9, 2016: ChemSusChem
https://www.readbyqxmd.com/read/27860207/mediterranean-diet-gene-interactions-a-targeted-metabolomics-study-in-greek-cypriot-women
#3
Maria G Kakkoura, Kleitos Sokratous, Christiana A Demetriou, Maria A Loizidou, Giorgos Loucaides, Eleni Kakouri, Andreas Hadjisavvas, Kyriacos Kyriacou
SCOPE: A high adherence to the Mediterranean diet (MD) was previously associated with a decreased risk of breast cancer (BC) among Greek-Cypriot women. Additionally, particular polymorphisms were shown to modulate this MD-BC association. Herein, we aimed to investigate the effect of polymorphisms-MD interactions on the levels of specific metabolites that could be related to dietary adherence or enzymatic activity, which is itself modulated by polymorphisms. METHODS AND RESULTS: Greek-Cypriot women who were BC controls and had the lowest or the highest MD adherence (vegetables, fruit, legumes, fish) as assessed by principal component analysis (n = 564) were included...
November 18, 2016: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/27774577/retrospective-case-control-study-of-correlation-between-mthfr-gene-and-oscc-risk-in-north-india
#4
Hena Naqvi, Mohammad Kaleem Ahmad, Syed Rizwan Hussain, Shalini Gupta, Mohammad Waseem, Abbas Ali Mahdi
BACKGROUND: Oral squamous cell carcinoma (OSCC) occurrence appears to be the number one among all cancers in India. Folate is a methyl donor during DNA methylation, as it provides substrate for methylenetetrahydrofolate reductase (MTHFR) to convert 5,10-MTHF to 5-MTHF and subsequently metabolizes it to methionine. The purpose of this study was to identify MTHFR C677T gene polymorphism in patients with OSCC. MATERIALS AND METHODS: A total of 350 OSCC cases and 350 healthy controls participated in this study...
October 24, 2016: Clinical Oral Investigations
https://www.readbyqxmd.com/read/27706773/relationship-between-genetic-polymorphisms-of-methylenetetrahydrofolate-reductase-and-breast-cancer-chemotherapy-response
#5
L Yang, X W Wang, L P Zhu, H L Wang, B Wang, T Wu, Q Zhao, D L X T JinSiHan, X Y Wang
Activity of methylenetetrahydrofolate reductase (MTHFR), an enzyme involved in folate metabolism, is influenced by mutations in the corresponding gene, contributing to a decrease in 5,10-MTHF. Due to such polymorphisms, individuals differ in MTHFR enzyme activity and plasma folate levels. We investigated the relationship between two common MTHFR polymorphisms (C677T and A1298C) and breast cancer (BC) chemotherapy response. From February 2013 to January 2016, 148 advanced BC patients at the Center Hospital of Cangzhou were enrolled and treated with six different chemotherapy regimens...
September 23, 2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27556743/atmospheric-chemistry-of-tetrahydrofuran-2-methyltetrahydrofuran-and-2-5-dimethyltetrahydrofuran-kinetics-of-reactions-with-chlorine-atoms-od-radicals-and-ozone
#6
Christina Andersen, Ole John Nielsen, Freja F Østerstrøm, Stina Ausmeel, Elna J K Nilsson, Mads P Sulbaek Andersen
FTIR smog chamber techniques were used to study the kinetics of the gas-phase reactions of Cl atoms, OD radicals, and O3 with the five-membered ring-structured compounds tetrahydrofuran (C4H8O, THF), 2-methyltetrahydrofuran (CH3C4H7O, 2-MTHF), 2,5-dimethyltetrahydrofuran ((CH3)2C4H5O, 2,5-DMTHF), and furan (C4H4O). The rate coefficients determined using relative rate methods were kTHF+Cl = (1.96 ± 0.24) × 10(-10), kTHF+OD = (1.81 ± 0.27) × 10(-11), kTHF+O3 = (6.41 ± 2.90) × 10(-21), k2-MTHF+Cl = (2.65 ± 0...
September 22, 2016: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/27523499/neurometabolic-disorders-potentially-treatable-abnormalities-in-patients-with-treatment-refractory-depression-and-suicidal-behavior
#7
Lisa A Pan, Petra Martin, Thomas Zimmer, Anna Maria Segreti, Sivan Kassiff, Brian W McKain, Cynthia A Baca, Manivel Rengasamy, Keith Hyland, Nicolette Walano, Robert Steinfeld, Marion Hughes, Steven K Dobrowolski, Michele Pasquino, Rasim Diler, James Perel, David N Finegold, David G Peters, Robert K Naviaux, David A Brent, Jerry Vockley
OBJECTIVE: Treatment-refractory depression is a devastating condition with significant morbidity, mortality, and societal cost. At least 15% of cases of major depressive disorder remain refractory to treatment. The authors previously identified a young adult with treatment-refractory depression and multiple suicide attempts with an associated severe deficiency of CSF tetrahydrobiopterin, a critical cofactor for monoamine neurotransmitter synthesis. Treatment with sapropterin, a tetrahydrobiopterin analogue, led to dramatic and long-lasting remission of depression...
August 13, 2016: American Journal of Psychiatry
https://www.readbyqxmd.com/read/27507672/homocysteine-metabolism-is-associated-with-cerebrospinal-fluid-levels-of-soluble-amyloid-precursor-protein-and-amyloid-beta
#8
Aikaterini Oikonomidi, Piotr Lewczuk, Johannes Kornhuber, Yvo Smulders, Michael Linnebank, Alexander Semmler, Julius Popp
Disturbed homocysteine metabolism may contribute to amyloidogenesis by modulating the amyloid precursor protein (APP) production and processing. The objective of this study was to investigate the relationships between cerebral amyloid production and both blood and cerebrospinal fluid (CSF) markers of the homocysteine metabolism. We assessed CSF concentrations of soluble APPα, soluble APPβ, and amyloid β1-42 (Aβ1-42), as well as plasma levels of homocysteine (Hcys), total vitamin B12, and folate, and CSF concentrations of homocysteine (Hcys-CSF), 5-methyltetrahydrofolate (5-MTHF), S-adenosylmethionine (SAM), and S-adenosylhomocysteine (SAH) in 59 subjects with normal cognition...
October 2016: Journal of Neurochemistry
https://www.readbyqxmd.com/read/27464831/homogeneous-catalyzed-reactions-of-levulinic-acid-to-%C3%AE-valerolactone-and-beyond
#9
REVIEW
Uwaila Omoruyi, Samuel Page, Jason Hallett, Philip W Miller
Platform chemicals derived from lignocellulosic plant biomass are viewed as a sustainable replacement for crude oil-based feedstocks. Levulinic acid (LA) is one such biomass-derived chemical that has been widely studied for further catalytic transformation to γ-valerolactone (GVL), an important 'green' fuel additive, solvent, and fine chemical intermediate. Although the transformation of LA to GVL can be achieved using heterogeneous catalysis, homogeneous catalytic systems that operate under milder reactions, give higher selectivities and can be recycled continuously are attracting considerable attention...
August 23, 2016: ChemSusChem
https://www.readbyqxmd.com/read/27463507/fad-and-mthf-are-the-in-planta-cofactors-of-arabidopsis-thaliana-cryptochrome-3
#10
Tanja Göbel, Stefan Reisbacher, Alfred Batschauer, Richard Pokorny
Members of the cryptochrome/photolyase family (CPF) of proteins utilize non-covalently bound light-absorbing cofactors for their biological function. Usually, the identity of these cofactors is determined after expression in heterologous systems leaving the question unanswered whether these cofactors are identical to the indigenous ones. Here, cryptochrome 3 from Arabidopsis thaliana was expressed as a fusion with the green fluorescent protein in Arabidopsis plants. Besides the confirmation of the earlier report of its localization in chloroplasts, our data indicate that fractions of the fusion protein are present in the stroma and associated with thylakoids, respectively...
July 27, 2016: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/27404261/supplementary-management-of-functional-temporary-alcoholic-hepatic-damage-with-robuvit%C3%A2-french-oak-wood-extract
#11
Luciano Pellegrini, Gianni Belcaro, Mark Dugall, Marcello Corsi, Roberta Luzzi, Masayuki Hosoi
BACKGROUND: The aim of this registry study was to evaluate Robuvit® (French oak wood extract) supplementation in the evolution of moderate functional hepatic failure (MTHF) due to alcohol. Recent studies have indicated the protective effect of oak wood (QR) extracts on liver injury. This registry included patients with MTHF characterized by: decreased albumin levels; increased total bilirubin, altered hepatic functions enzymes, increased oxidative stress, negative viral hepatitis markers...
September 2016: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/27377401/continuous-hydrogenation-of-ethyl-levulinate-to-%C3%AE-valerolactone-and-2-methyl-tetrahydrofuran-over-alumina-doped-cu-sio2-catalyst-the-potential-of-commercialization
#12
Junlin Zheng, Junhua Zhu, Xuan Xu, Wanmin Wang, Jiwen Li, Yan Zhao, Kangjian Tang, Qi Song, Xiaolan Qi, Dejin Kong, Yi Tang
Hydrogenation of levulinic acid (LA) and its esters to produce γ-valerolactone (GVL) and 2-methyl tetrahydrofuran (2-MTHF) is a key step for the utilization of cellulose derived LA. Aiming to develop a commercially feasible base metal catalyst for the production of GVL from LA, with satisfactory activity, selectivity, and stability, Al2O3 doped Cu/SiO2 and Cu/SiO2 catalysts were fabricated by co-precipitation routes in parallel. The diverse physio-chemical properties of these two catalysts were characterized by XRD, TEM, dissociative N2O chemisorptions, and Py-IR methods...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27243931/acute-embryo-toxicity-and-teratogenicity-of-three-potential-biofuels-also-used-as-flavor-or-solvent
#13
Kerstin Bluhm, Thomas-Benjamin Seiler, Nico Anders, Jürgen Klankermayer, Andreas Schaeffer, Henner Hollert
The demand for biofuels increases due to concerns regarding greenhouse gas emissions and depletion of fossil oil reserves. Many substances identified as potential biofuels are solvents or already used as flavors or fragrances. Although humans and the environment may be readily exposed little is known regarding their (eco)toxicological effects. In this study, the three potential biofuels ethyl levulinate (EL), 2-methyltetrahydrofuran (2-MTHF) and 2-methylfuran (2-MF) were investigated for their acute embryo toxicity and teratogenicity using the fish embryo toxicity (FET) test to identify unknown hazard potentials and to allow focusing further research on substances with low toxic potentials...
October 1, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27178705/csf-concentrations-of-5-methyltetrahydrofolate-in-a-cohort-of-young-children-with-autism
#14
John Shoffner, Barbara Trommer, Audrey Thurm, Cristan Farmer, William A Langley, Laura Soskey, Aldeboran N Rodriguez, Precilla D'Souza, Sarah J Spence, Keith Hyland, Susan E Swedo
OBJECTIVE: To examine the association between cerebral folate deficiency and autism, this study examined CSF 5-methyltetrahydrofolate (5-MTHF) concentrations in a group of young children with autism, investigated the natural variation in CSF 5-MTHF over time, and assessed the relationship between CSF 5-MTHF and symptoms. METHODS: CSF was collected from 67 children with a diagnosis of DSM-IV-TR autistic disorder (age, mean ± SD 43 ± 11 months), with a second CSF sample obtained 1-3 years later on 31 of these subjects (time to follow-up, 30 ± 8 months)...
June 14, 2016: Neurology
https://www.readbyqxmd.com/read/27068282/the-basis-for-folinic-acid-treatment-in-neuro-psychiatric-disorders
#15
REVIEW
V T Ramaekers, J M Sequeira, E V Quadros
Multiple factors such as genetic and extraneous causes (drugs, toxins, adverse psychological events) contribute to neuro-psychiatric conditions. In a subgroup of these disorders, systemic folate deficiency has been associated with macrocytic anemia and neuropsychiatric phenotypes. In some of these, despite normal systemic levels, folate transport to the brain is impaired in the so-called cerebral folate deficiency (CFD) syndromes presenting as developmental and psychiatric disorders. These include infantile-onset CFD syndrome, infantile autism with or without neurologic deficits, a spastic-ataxic syndrome and intractable epilepsy in young children expanding to refractory schizophrenia in adolescents, and finally treatment-resistant major depression in adults...
July 2016: Biochimie
https://www.readbyqxmd.com/read/27008238/enhanced-oral-bioavailability-of-a-novel-folate-salt-comparison-with-folic-acid-and-a-calcium-folate-salt-in-a-pharmacokinetic-study-in-rats
#16
Niccolò Miraglia, Marco Agostinetto, Davide Bianchi, Ermanno Valoti
BACKGROUND: Folates play an important role to prevent neurological disorders in embryo development and in cardiovascular diseases. Folate supplementation is suggested, particularly in females of childbearing age, for the prevention of embryonal NTDs during pregnancy. Folic acid and reduced folate ((6S)5-MTHF) are currently used in supplementation. The aim of this study was to compare the bioavailability of Quatrefolic®, a novel patented (6S)5-MTHF glucosamine salt, with (6S)5-MTHF calcium salt and folic acid in Sprague Dawley rats...
April 2016: Minerva Ginecologica
https://www.readbyqxmd.com/read/26938040/supplementary-management-of-functional-temporary-alcoholic-hepatic-damage-with-robuvit%C3%A2-french-oak-wood-extract
#17
Luciano Pellegrini, Gianni Belcaro, Mark Dugall, Marcello Corsi, Roberta Luzzi, Masayuki Hosoi
: The aim of this registry study was to evaluate Robuvit® (quercus robur wood extract) supplementation in the evolution of moderate functional hepatic failure (MTHF) due to alcohol. Recent studies have indicated the protective effect of oak wood (QR) extracts on liver injury. This registry included patients with MTHF characterized by: decreased albumin levels; increased total bilirubin, altered hepatic functions enzymes, increased oxidative stress, negative viral hepatitis markers. RESULTS: The two groups resulted divided into a best management (BM) group and a comparative group (BM+ Robuvit ® were comparable): 23 Robuvit® patients and 21 comparable controls completed the 12-week registry...
March 3, 2016: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/26912861/mtorc1-induces-purine-synthesis-through-control-of-the-mitochondrial-tetrahydrofolate-cycle
#18
Issam Ben-Sahra, Gerta Hoxhaj, Stéphane J H Ricoult, John M Asara, Brendan D Manning
In response to growth signals, mechanistic target of rapamycin complex 1 (mTORC1) stimulates anabolic processes underlying cell growth. We found that mTORC1 increases metabolic flux through the de novo purine synthesis pathway in various mouse and human cells, thereby influencing the nucleotide pool available for nucleic acid synthesis. mTORC1 had transcriptional effects on multiple enzymes contributing to purine synthesis, with expression of the mitochondrial tetrahydrofolate (mTHF) cycle enzyme methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) being closely associated with mTORC1 signaling in both normal and cancer cells...
February 12, 2016: Science
https://www.readbyqxmd.com/read/26898294/treatment-with-mefolinate-5-methyltetrahydrofolate-but-not-folic-acid-or-folinic-acid-leads-to-measurable-5-methyltetrahydrofolate-in-cerebrospinal-fluid-in-methylenetetrahydrofolate-reductase-deficiency
#19
L Knowles, A A M Morris, J H Walter
S-adenosyl methionine, which is formed from methionine, is an essential methyl donor within the central nervous system. Methionine is formed by the enzyme methionine synthase for which 5-methyltetrahydrofolate (5-MTHF) and homocysteine are substrates. Patients with severe methylenetetrahydrofolate reductase (MTHFR) deficiency cannot make 5-MTHF and have extremely low levels in the CSF. As a consequence, methylation reactions in the CNS are compromised, and this is likely to play an important role in the neurological abnormalities that occur in MTHFR deficiency...
February 23, 2016: JIMD Reports
https://www.readbyqxmd.com/read/26821044/impact-of-food-rations-and-supplements-on-micronutrient-status-by-trimester-of-pregnancy-cross-sectional-studies-in-the-maela-refugee-camp-in-thailand
#20
Wolfgang Stuetz, Verena I Carrara, Rose Mc Gready, Sue J Lee, Kanlaya Sriprawat, Basi Po, Borimas Hanboonkunupakarn, Tilman Grune, Hans K Biesalski, François H Nosten
Micronutrient fortified flour (MFF), supplementary food rations and micronutrient (MN) supplements may prevent deficiencies among pregnant women. Objectives of cross-sectional surveys in 2004 (n = 533) and 2006 (n = 515) were to assess the impact of new food rations (flour, oil) and supplements on MN status by trimester of pregnancy in the Maela refugee camp. Hemoglobin, iron status, zinc, retinol, β-carotene and tryptophan decreased, while α-/γ-tocopherol and 5-methyltetrahydrofolate (5-MTHF) increased from first to third trimester...
January 26, 2016: Nutrients
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