keyword
https://read.qxmd.com/read/38536555/folate-induces-stemness-and-increases-oxygen-consumption-under-glucose-deprivation-by-notch-1-pathway-activation-in-colorectal-cancer-cell
#1
JOURNAL ARTICLE
Juan Rodríguez Silva, Matías Monsalves-Álvarez, Carlos Sepúlveda, Camila Donoso-Barraza, Rodrigo Troncoso, Sandra Hirsch
Evidence for folate's protective effects on neural tube defects led the USA and Chile to start mandatory folic acid (FA) fortification programs, decreasing up to 50%. However, ∼30% of the population consuming fortified foods reach supraphysiologic serum levels. Although controversial, several epidemiological and clinical observations suggest that folate increases cancer risk, giving concern about the risks of FA supplementation. The Cancer stem cells (CSCs) model has been used to explain survival to anticancer therapies...
March 27, 2024: Molecular and Cellular Biochemistry
https://read.qxmd.com/read/38465829/binary-solvent-induced-stable-interphase-layer-for-ultra-long-life-sodium-metal-batteries
#2
JOURNAL ARTICLE
Rinish Reddy Vaidyula, Mai H Nguyen, Jason A Weeks, Yixian Wang, Ziqing Wang, Kenta Kawashima, Austin G Paul-Orecchio, Hugo Celio, Andrei Dolocan, Graeme Henkelman, C Buddie Mullins
Sodium foil, promising for high-energy-density batteries, faces reversibility challenges due to its inherent reactivity and unstable solid electrolyte interphase (SEI) layer. In this study, we achieve a stable sodium metal battery by tuning the electrolyte solvation structure through the addition of co-solvent 2-methyl tetrahydrofuran (MTHF) to diglyme (Dig). The introduction of cyclic ether-based MTHF results in increased anion incorporation in the solvation structure, even at lower salt concentrations. Specifically, the anion stabilization capabilities of the environmentally sustainable MTHF co-solvent lead to a contact-ion pair-based solvation structure...
March 11, 2024: Advanced Materials
https://read.qxmd.com/read/38202825/catalytic-conversion-of-levulinic-acid-into-2-methyltetrahydrofuran-a-review
#3
REVIEW
Sreedhar Gundekari, Sanjib Kumar Karmee
Biomass-derived furanics play a pivotal role in chemical industries, with 2-methyltetrahydrofuran (2-MTHF), a hydrogenated product of levulinic acid (LA), being particularly significant. 2-MTHF finds valuable applications in the fuel, polymer, and chemical sectors, serving as a key component in P-series biofuel and acknowledged as a renewable solvent for various chemical processes. Numerous research groups have explored catalytic systems to efficiently and selectively convert LA to 2-MTHF, using diverse metal-supported catalysts in different solvents under batch or continuous process conditions...
January 2, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38175236/role-of-folic-acid-in-regulating-gut-microbiota-and-short-chain-fatty-acids-based-on-an-in-vitro-fermentation-model
#4
JOURNAL ARTICLE
Xiaogu Zheng, Chenlan Xia, Manman Liu, Hongchen Wu, Jiaqian Yan, Zihao Zhang, Yingjie Huang, Qing Gu, Ping Li
Folic acid deficiency is common worldwide and is linked to an imbalance in gut microbiota. However, based on model animals used to study the utilization of folic acid by gut microbes, there are challenges of reproducibility and individual differences. In this study, an in vitro fecal slurry culture model of folic acid deficiency was established to investigate the effects of supplementation with 5-methyltetrahydrofolate (MTHF) and non-reduced folic acid (FA) on the modulation of gut microbiota. 16S rRNA sequencing results revealed that both FA (29...
December 2024: Applied Microbiology and Biotechnology
https://read.qxmd.com/read/38058766/cyp2u1-an-emerging-treatable-neurometabolic-disease-with-cerebral-folate-deficiency-in-2-chinese-brothers
#5
Sheila Suet-Na Wong, Liz Yuet-Ping Yuen, Elaine Kan, Nenad Blau, Richard Rodenburg, Ching-Wan Lam, Virginia Chun-Nei Wong, Fanny Mochel, Ron A Wevers, Cheuk-Wing Fung
With the rapid advancement of medical technologies in genomic and molecular medicine, the number of treatable neurometabolic diseases is quickly expanding. Spastic paraplegia 56 (SPG56), one of the severe autosomal recessive forms of neurodegenerative disorders caused by pathogenic variants in the CYP2U1 gene, has no reported specific targeted treatment yet. Here we report 2 Chinese brothers with CYP2U1 bi-allelic pathogenic variants with cerebral folate deficiency who were treated for over a decade with folinic acid supplement...
March 2024: Molecular Genetics and Metabolism Reports
https://read.qxmd.com/read/38057412/human-milk-oligosaccharide-composition-following-supplementation-with-folic-acid-vs-6s-5-methyltetrahydrofolic-acid-during-pregnancy-and-mediation-by-human-milk-folate-forms
#6
JOURNAL ARTICLE
Kelsey M Cochrane, Jeffrey N Bone, Crystal D Karakochuk, Lars Bode
Supplementation with folic acid versus (6S)-5-methyltetrahydrofolic acid (5-MTHF) results in different folate forms in human milk, with folic acid increasing unmetabolized folic acid (UMFA) at the expense of reduced folate forms. It is unknown whether folate forms present in human milk have further effects on human milk composition, such as human milk oligosaccharide (HMO) concentrations. We randomized 60 pregnant women in Canada to 0.6 mg/day folic acid or (6S)-5-MTHF. Human milk folate forms (LC-MS/MS) and nineteen HMOs (HPLC) were quantified at 1 week postpartum...
December 6, 2023: European Journal of Clinical Nutrition
https://read.qxmd.com/read/38035146/safety-of-monosodium-salt-of-l-5-methyltetrahydrofolic-acid-as-a-novel-food-pursuant-to-regulation-eu-2015-2283-and-the-bioavailability-of-folate-from-this-source-in-the-context-of-directive-2002-46-ec-regulation-eu-no-609-2013-and-regulation-ec-no-1925-2006
#7
JOURNAL ARTICLE
Dominique Turck, Torsten Bohn, Jacqueline Castenmiller, Stefaan De Henauw, Karen Ildico Hirsch-Ernst, Alexandre Maciuk, Inge Mangelsdorf, Harry J McArdle, Androniki Naska, Kristina Pentieva, Alfonso Siani, Frank Thies, Sophia Tsabouri, Marco Vinceti, Margarita Aguilera-Gómez, Francesco Cubadda, Thomas Frenzel, Marina Heinonen, Miguel Prieto Maradona, Rosangela Marchelli, Monika Neuhäuser-Berthold, Morten Poulsen, Josef Rudolf Schlatter, Alexandros Siskos, Henk van Loveren, Leonard Matijević, Helle Katrine Knutsen
Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver an opinion on monosodium salt of l-5-methyltetrahydrofolic acid (5-MTHF) as a novel food (NF) pursuant to Regulation (EU) 2015/2283 and to address the bioavailability of folate from this source in the context of Directive 2002/46/EC, Regulation (EU) No 609/2013 and Regulation (EC) No 1925/2006. The NF is produced by chemical synthesis and consists of at least 95% (w/w) of 5-MTHF and 4%-5% (w/w) of sodium...
November 2023: EFSA journal
https://read.qxmd.com/read/37894974/molecular-mechanisms-provide-a-landscape-for-biomarker-selection-for-schizophrenia-and-schizoaffective-psychosis
#8
REVIEW
Stephanie Fryar-Williams, Jörg Strobel, Peter Clements
Research evaluating the role of the 5,10-methylenetetrahydrofolate reductase ( MTHFR C677T ) gene in schizophrenia has not yet provided an extended understanding of the proximal pathways contributing to the 5-10-methylenetetrahydrofolate reductase (MTHFR) enzyme's activity and the distal pathways being affected by its activity. This review investigates these pathways, describing mechanisms relevant to riboflavin availability, trace mineral interactions, and the 5-methyltetrahydrofolate (5-MTHF) product of the MTHFR enzyme...
October 18, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37855634/the-sensor-histidine-kinase-sln1-and-acetyl-coa-carboxylase-acc1-coordinately-regulate-the-response-of-neurospora-crassa-to-the-springtail-sinella-curviseta-collembola-entomobryidae-attack
#9
JOURNAL ARTICLE
Mengni Sun, Ting Lu, Pengxu Chen, Xiaomeng Wang, Hanbing Yang, Rong Zhou, Weifa Zheng, Yanxia Zhao
Eukaryotes evolved various strategies to coordinate their development and metabolism in response to harsh environments. However, it remains unknown whether fungi increase their resistance to stress from fungivorous arthropods by altering phenotype and metabolite composition. In this study, we investigated the coordinated regulation of sensor histidine kinase (SLN1) and acetyl-CoA carboxylase (ACC1) on sporulation and metabolite accumulation in Neurospora crassa , particularly upon the springtail Sinella curviseta (Collembola: Entomobryidae) attack...
October 19, 2023: Applied and Environmental Microbiology
https://read.qxmd.com/read/37824254/diverse-associations-observed-between-pregnancy-complications-and-rbc-or-plasma-folates-determined-by-an-in-house-developed-lc-ms-ms-method
#10
JOURNAL ARTICLE
Zhengwen Xu, Youran Li, Ying Liu, Shengmin Liu, Lin Zhang, Jing Wang, Shaofei Su, Lin Liu, Lanlan Meng, Hongyuan Zhu, Jingru Sun, Lijun Shao, Lin Li, Yanhong Zhai, Guanghui Li, Zheng Cao
BACKGROUND: As folates are essential for embryonic development and growth, it is necessary to accurately determine the levels of folates in plasma and red blood cells (RBCs) for clinical intervention. The aims of this study were to develop and validate a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for quantitation of folates in plasma and RBCs and to examine the association between plasma and RBC folate concentrations and gestational diabetes mellitus (GDM), gestational hypertension (GH) and preeclampsia (PE)...
2023: Annals of Medicine
https://read.qxmd.com/read/37819550/the-importance-of-preconception-hcy-testing-identification-of-a-folate-trap-syndrome-in-a-woman-attending-an-assisted-reproduction-program
#11
JOURNAL ARTICLE
Arthur Clément, Patrice Clément, Géraldine Viot, Yves J R Menezo
Methylation is a ubiquitous and permanent key biochemical process playing a major role in gametogenesis and embryogenesis in relation to epigenetics and imprinting. Methylation relies on a unique cofactor S-Adenosyl Methionine: SAM. Release of the methyl group onto target molecules is followed by liberation of S-Adenosyl Homocysteine (SAH), and then homocysteine (Hcy), both potent inhibitors of the methylation process. Defective recycling of homocysteine, leading to Hyperhomocysteinemia, is mainly due to reduced activity of MTHFR (Methylene TetraHydroFolate Reductase)...
October 11, 2023: Journal of Assisted Reproduction and Genetics
https://read.qxmd.com/read/37781132/association-of-folic-acid-dosage-with-circulating-unmetabolized-folic-acid-in-chinese-adults-with-h-type-hypertension-a-multicenter-double-blind-randomized-controlled-trial
#12
JOURNAL ARTICLE
Ping Chen, Linlin Tang, Yun Song, Binyan Wang, Xianhui Qin, Nan Zhang, Yaping Wei, Xiping Xu, Ziyi Zhou, Qiangqiang He, Lishun Liu, Sultan Mehmood Siddiqi, Xiao Huang, Xiaoshu Cheng, Genfu Tang, Yong Duan, Houqing Zhou, Jie Jiang, Sha Li
BACKGROUND: There is growing concern regarding elevated levels of circulating unmetabolized folic acid (UMFA) due to excessive intake of folic acid (FA). However, no randomized clinical trial has been conducted to examine the FA-UMFA dose-response relationship. OBJECTIVE: This study aimed to investigate the FA-UMFA dose-response relationship in Chinese adults with hypertension and elevated homocysteine (H-type hypertension), a population with clear clinical indication for FA treatment...
2023: Frontiers in Nutrition
https://read.qxmd.com/read/37705678/hyperhomocysteinemia-in-hypofertile-male-patients-can-be-alleviated-by-supplementation-with-5mthf-associated-with-one-carbon-cycle-support
#13
JOURNAL ARTICLE
Arthur Clement, Edouard Amar, Patrice Clement, Éric Sedbon, Charles Brami, Silvia Alvarez, Yves Menezo
INTRODUCTION: Homocysteine (Hcy) is a cellular poison, side product of the hydrolysis of S-Adenosyl Homocysteine, produced after the universal methylation effector S -Adenosylmethionine liberates a methyl group to recipient targets. It inhibits the methylation processes and its rising is associated with multiple disease states and ultimately is both a cause and a consequence of oxidative stress, affecting male gametogenesis. We have determined hyper homocysteinhemia (HHcy) levels can be reliably reduced in hypofertile patients in order to decrease/avoid associated epigenetic problems and protect the health of future children, in consideration of the fact that treatment with high doses of folic acid is inappropriate...
2023: Front Reprod Health
https://read.qxmd.com/read/37649241/supplementation-with-6-s-5-methyltetrahydrofolic-acid-appears-as-effective-as-folic-acid-in-maintaining-maternal-folate-status-while-reducing-unmetabolised-folic-acid-in-maternal-plasma-a-randomised-trial-of-pregnant-women-in-canada
#14
JOURNAL ARTICLE
Kelsey M Cochrane, Rajavel Elango, Angela M Devlin, Chantal Mayer, Jennifer A Hutcheon, Crystal D Karakochuk
Folic acid supplementation is recommended during pregnancy to support healthy fetal development; (6 S )-5-methyltetrahydrofolic acid ((6 S )-5-MTHF) is available in some commercial prenatal vitamins as an alternative to folic acid, but its effect on blood folate status during pregnancy is unknown. To address this, we randomised sixty pregnant individuals at 8-21 weeks' gestation to 0·6 mg/d folic acid or (6 S )-5-MTHF × 16 weeks. Fasting blood specimens were collected at baseline and after 16 weeks (endline)...
August 10, 2023: British Journal of Nutrition
https://read.qxmd.com/read/37624487/efficacy-and-mechanism-study-of-6s-5-methyltetrahydrofolate-calcium-against-telencephalon-infarction-injury-in-zebrafish-model-of-ischemic-stroke
#15
JOURNAL ARTICLE
Xin-Ni Bin, Tao-Jun Xu, Han-Peng Zou, Zenglin Lian, Yongzhi Cheng, Jia-Qi Wu, Ming-Fang He
Ischemic stroke is a heterogeneous brain injury with complex pathophysiology and it is also a time sensitive neurological injury disease. At present, the treatment options for ischemic stroke are still limited. 6S-5-methyltetrahydrofolate-calcium (MTHF-Ca) is the calcium salt of the predominant form of dietary folate in circulation. MTHF-Ca has potential neuroprotective effect on neurocytes, but whether it can be used for ischemic stroke treatment remains unknown. We established zebrafish ischemic stroke model through photothrombotic method to evaluate the protective effect of MTHF-Ca on the ischemic brain injury of zebrafish...
August 25, 2023: Molecular Neurobiology
https://read.qxmd.com/read/37482222/5-mthf-enhances-the-portal-pressure-reduction-achieved-with-propranolol-in-patients-with-cirrhosis-a-randomized-placebo-controlled-trial
#16
RANDOMIZED CONTROLLED TRIAL
Ranka Vukotic, Roberto Di Donato, Greta Roncarati, Patrizia Simoni, Matteo Renzulli, Stefano Gitto, Filippo Schepis, Erica Villa, Annalisa Berzigotti, Jaume Bosch, Pietro Andreone
BACKGROUND & AIMS: β-blockers reduce hepatic venous pressure gradient (HVPG) by decreasing portal inflow, with no reduction in intrahepatic vascular resistance. 5-Methyltetrahydrofolate (5-MTHF) can prevent oxidative loss of tetrahydrobiopterin (BH4), a cofactor for endothelial nitric oxide synthase coupling. It also converts homocysteine (tHcy) into methionine and enables the degradation of asymmetric dimethylarginine (ADMA), an inhibitor of endothelial nitric oxide synthase...
October 2023: Journal of Hepatology
https://read.qxmd.com/read/37446171/serum-5-methyltetrahydrofolate-status-is-associated-with-one-carbon-metabolism-related-metabolite-concentrations-and-enzyme-activity-indicators-in-young-women
#17
JOURNAL ARTICLE
Yoshinori Kubo, Kumiko Shoji, Akiko Tajima, Sayaka Horiguchi, Hideoki Fukuoka, Masazumi Nishikawa, Yasuo Kagawa, Terue Kawabata
Maintaining optimal one-carbon metabolism (OCM) is essential for health and pregnancy. In this cross-sectional study, folate status was assessed based on 5-methyltetrahydrofolate (5-MTHF) levels, and the association between 5-MTHF and OCM-related metabolites was investigated in 227 female Japanese university students aged 18-25 years. The participants were divided into high and low 5-MTHF groups based on their folate status. Serum samples of the participants were collected while they were fasting, and 18 OCM-related metabolites were measured using stable-isotope dilution liquid chromatography-electrospray tandem mass spectrometry...
July 1, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37439279/the-regulation-function-of-intestinal-microbiota-by-folate-producing-lactiplantibacillus-plantarum-lz227-the-regulation-of-microbiota-by-folate-producing-lactiplantibacillus-plantarum
#18
JOURNAL ARTICLE
Hongchen Wu, Yingjie Huang, Manman Liu, Xiaogu Zheng, Zihao Zhang, Xiangfeng Chen, Qing Gu, Ping Li
BACKGROUND: Folic acid is a class of B vitamins that have the function of improving intestinal microbiota. RESULT: Lactiplantibacillus plantarum(L. plantarum) LZ227, which is a highly folate-producing strain, was used as the research object, and the folic acid produced by LZ227 was further identified by LC-MS, and the structural diversity, community composition, abundance difference, and short-chain fatty acids(SCFAs) content in fermentation broth were studied by the manure slurry fermentation model...
July 13, 2023: Journal of the Science of Food and Agriculture
https://read.qxmd.com/read/37438496/human-milk-unmetabolized-folic-acid-is-increased-following-supplementation-with-synthetic-folic-acid-as-compared-to-6s-5-methyltetrahydrofolic-acid
#19
JOURNAL ARTICLE
Kelsey M Cochrane, Rajavel Elango, Angela M Devlin, Jennifer A Hutcheon, Crystal D Karakochuk
Folic acid supplementation is recommended perinatally, but may increase unmetabolized folic acid (UMFA) in human milk; this is concerning as it is an inactive form which may be less bioavailable for the infant. "Natural" (6S)-5-methyltetrahydrofolic acid [(6S)-5-MTHF] is available as an alternative to folic acid, and may prevent the accumulation of UMFA in human milk. Pregnant women (n = 60) were enrolled at 8-21 weeks of gestation and randomized to 0.6 mg/day folic acid or (6S)-5-MTHF...
July 12, 2023: Scientific Reports
https://read.qxmd.com/read/37318681/predicting-the-effect-of-different-folate-doses-on-68-ga-ga-psma-11-organ-and-tumor-uptake-using-physiologically-based-pharmacokinetic-modeling
#20
JOURNAL ARTICLE
Hinke Siebinga, Jeroen J M A Hendrikx, Alwin D R Huitema, Berlinda J de Wit-van der Veen
BACKGROUND: Folate intake might reduce [68 Ga]Ga-PSMA-11 uptake in tissues due to a competitive binding to the PSMA receptor. For diagnostic imaging, this could impact decision making, while during radioligand therapy this could affect treatment efficacy. The relationship between folate dose, timing of dosing and tumor and organ uptake is not well established. The aim of this study was to develop a physiologically based pharmacokinetic (PBPK) model to predict the effect of folates on [68 Ga]Ga-PSMA-11 PET/CT uptake in salivary glands, kidneys and tumors...
June 15, 2023: EJNMMI Research
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