keyword
https://read.qxmd.com/read/38389986/abstinence-duration-and-psychopathology-among-addiction-outpatients-during-18-months-of-covid-19
#1
JOURNAL ARTICLE
Constanza Daigre, Raul Felipe Palma-Álvarez, Marta Sorribes-Puertas, German Ortega-Hernández, Marta Perea-Ortueta, Elena Ros-Cucurull, Lidia Segura, Joan Colom, Maria Dolores Braquehais, Josep Antoni Ramos-Quiroga, Lara Grau-López
BACKGROUND: The COVID-19 pandemic has impacted the mental health of patients with substance use disorder (SUD). However, few longitudinal studies have been done which examine associations between the pandemic, SUD patients' mental health and their drug use. OBJECTIVES: This study aimed to examine duration of abstinence according to psychiatric status among SUD outpatients followed-up for 18 months from the pandemic related lockdown. METHODS: A follow-up study of 316 SUD outpatients was undertaken...
2024: Frontiers in Psychiatry
https://read.qxmd.com/read/38255861/the-relationship-between-the-brain-derived-neurotrophic-factor-gene-polymorphism-val66met-and-substance-use-disorder-and-relapse
#2
JOURNAL ARTICLE
Aleksandra Strońska-Pluta, Aleksandra Suchanecka, Krzysztof Chmielowiec, Jolanta Chmielowiec, Agnieszka Boroń, Jolanta Masiak, Olimpia Sipak-Szmigiel, Remigiusz Recław, Anna Grzywacz
Substance addiction is a neuropsychiatric disorder characterized by a recurring desire to continue using a substance despite harmful consequences. Brain-derived neurotrophic factor (BDNF) is a protein that plays a role in the activity-dependent remodeling of neural function in adult nervous systems. This study analyzed the association of the rs6265 polymorphism of the BDNF gene in a group of patients addicted to psychoactive substances who were participating in addiction treatment for the first time, in a group of post-relapse psychoactive substance abusers and in a control group...
January 8, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/37981240/activity-space-during-treatment-with-medication-for-opioid-use-disorder-relationships-with-personality-mood-and-drug-use
#3
JOURNAL ARTICLE
Leigh V Panlilio, Albert J Burgess-Hull, Jeffrey D Feldman, Jeffrey M Rogers, Matthew Tyburski, Kirsten E Smith, David H Epstein
INTRODUCTION: Activity space in people with substance use disorders (SUDs) has been assessed for theoretical reasons and for detection/prevention of relapse. In this observational study, we relate passively obtained activity space measures to mental states and behaviors relevant to the success of treatment for opioid use disorder. Our long-term goal is to use such data to assess risk in real time and to recognize when SUD patients might benefit from a just-in-time intervention. METHODS: We used GPS data from 238 urban residents in the first 16 weeks of stabilization on medication for opioid use disorder to test preregistered hypotheses about activity space (distance traveled, number of locations, time spent moving, and psychosocial-hazard levels of neighborhoods where participants spent time) in relation to certain static variables (personality, mood propensities) and time-varying treatment-relevant behaviors such as craving and use of opioids and cocaine...
November 17, 2023: J Subst Use Addict Treat
https://read.qxmd.com/read/37575566/preliminary-evidence-for-changes-in-frontoparietal-network-connectivity-in-the-early-abstinence-period-in-alcohol-use-disorder-a-longitudinal-resting-state-functional-magnetic-resonance-imaging-study
#4
JOURNAL ARTICLE
Jasper van Oort, Nancy Diazgranados, David T George, Yvonne Horneffer, Melanie Schwandt, David Goldman, Reza Momenan
The early abstinence period is a crucial phase in alcohol use disorder (AUD) in which patients have to find a new equilibrium and may start recovery, or conversely, relapse. However, the changes in brain functions during this key period are still largely unknown. We set out to study longitudinal changes in large-scale brain networks during the early abstinence period using resting-state scans. We scanned AUD patients twice in a well-controlled inpatient setting, with the first scan taking place shortly after admission and the second scan 4 weeks (±9 days) later near the end of the treatment period...
2023: Frontiers in Psychiatry
https://read.qxmd.com/read/37552291/operant-novelty-seeking-predicts-cue-induced-reinstatement-following-cocaine-but-not-water-reinforcement-in-male-rats
#5
JOURNAL ARTICLE
Amy M Gancarz, Devin P Hagarty, Moriah M Cobb, Michael A Kausch, Brandon Krieg, Nora Alammari, Kameron Gilbert, Jacqueline Russo, David M Dietz
RATIONALE: An important facet of cocaine addiction is a high propensity to relapse, with increasing research investigating factors that predispose individuals toward uncontrolled drug use and relapse. A personality trait linked to drug addiction is high sensation seeking, i.e., a preference for novel sensations/experiences. In an animal model of sensation seeking, operant novelty seeking predicts the acquisition of drug self-administration. OBJECTIVE: The primary goal of this research was to evaluate the hypothesis that sensitivity to the reinforcing effects of novel sensory stimuli predicts more intensive aspects of drug-taking behaviors, such as relapse...
August 8, 2023: Psychopharmacology
https://read.qxmd.com/read/37304451/thc-exposure-during-adolescence-increases-impulsivity-like-behavior-in-adulthood-in-a-win-55-212-2-self-administration-mouse-model
#6
JOURNAL ARTICLE
María Del Mar Cajiao-Manrique, Verònica Casadó-Anguera, Alejandra García-Blanco, Rafael Maldonado, Elena Martín-García
BACKGROUND: Cannabis addiction is a chronically relapsing disorder lacking effective treatment. Regular cannabis consumption typically begins during adolescence, and this early cannabinoid exposure may increase the risk for drug addiction in adulthood. OBJECTIVE: This study investigates the development of cannabis addiction-like behavior in adult mice after adolescent exposure to the main psychoactive component of cannabis, Δ9 -tetrahydrocannabinol (THC). METHODS: Adolescent male mice were exposed to 5 mg/kg of THC from postnatal days 37 to 57...
2023: Frontiers in Psychiatry
https://read.qxmd.com/read/37243745/are-there-clinical-psychopathological-and-therapy-outcomes-correlates-associated-with-self-exclusion-from-gambling
#7
JOURNAL ARTICLE
Juan C Uríszar, Anahí Gaspar-Pérez, Roser Granero, Lucero Munguía, Milagros L Lara-Huallipe, Bernat Mora-Maltas, Isabel Baenas, Mikel Etxandi, Mónica Gómez-Peña, Laura Moragas, Claudia Sisquellas, Fernando Fernández-Aranda, Susana Jiménez-Murcia
BACKGROUND AND AIMS: Self-exclusion in gambling disorder (GD) is considered a measure to decrease the negative consequences of gambling behavior. Under a formal self-exclusion program, gamblers request to be banned from accessing to the gambling venues or online gambling. THE AIMS OF THE PRESENT STUDY ARE: 1) to determine sociodemographic characteristics of a clinical sample of seeking-treatment patients with GD who are self-excluded before arriving at the care unit; 2) to identify personality traits and general psychopathology of this clinical population; 3) to analyze the response to treatment, in terms of relapses and dropouts...
May 26, 2023: Journal of Behavioral Addictions
https://read.qxmd.com/read/37240004/neurotensin-and-alcohol-use-disorders-towards-a-pharmacological-treatment
#8
REVIEW
Francisco D Rodríguez, Manuel Lisardo Sánchez, Rafael Coveñas
Harmful alcohol use is responsible for a group of disorders collectively named alcohol use disorders (AUDs), according to the DSM-5 classification. The damage induced by alcohol depends on the amount, time, and consumption patterns (continuous and heavy episodic drinking). It affects individual global well-being and social and familial environments with variable impact. Alcohol addiction manifests with different degrees of organ and mental health detriment for the individual, exhibiting two main traits: compulsive drinking and negative emotional states occurring at withdrawal, frequently causing relapse episodes...
May 12, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37222495/mediating-effects-of-thought-suppression-in-the-relationship-between-mindfulness-and-substance-use-craving
#9
JOURNAL ARTICLE
Dierdre Smith-Russell, Sarah Bowen
Background : Substance use disorder (SUD) is a significant issue in the United States, characterized by chronic relapse following periods of abstinence. One of the primary precursors to relapse is craving. Findings from several studies have shown a negative association between trait mindfulness and craving in clinical samples; however, further research is needed to understand mechanisms underlying this relationship. Purpose/Objectives : The current study assessed thought suppression as a partial mediator of the relationship between trait mindfulness and craving...
May 24, 2023: Substance Use & Misuse
https://read.qxmd.com/read/37138216/functional-modular-networks-identify-the-pivotal-genes-associated-with-morphine-addiction-and-potential-drug-therapies
#10
JOURNAL ARTICLE
Yage Jiang, Donglei Wei, Yubo Xie
BACKGROUND: Chronic morphine usage induces lasting molecular and microcellular adaptations in distinct brain areas, resulting in addiction-related behavioural abnormalities, drug-seeking, and relapse. Nonetheless, the mechanisms of action of the genes responsible for morphine addiction have not been exhaustively studied. METHODS: We obtained morphine addiction-related datasets from the Gene Expression Omnibus (GEO) database and screened for Differentially Expressed Genes (DEGs)...
May 3, 2023: BMC Anesthesiology
https://read.qxmd.com/read/37063522/measuring-attentional-bias-in-smokers-during-and-after-psychosocial-stress-induction-with-a-trier-social-stress-test-in-virtual-reality-via-eye-tracking
#11
JOURNAL ARTICLE
Benedikt Schröder, Andreas Mühlberger
INTRODUCTION: Attentional bias (AB) is considered an important factor not only in the etiology of addiction, but also with respect to relapse. However, evidence for the predictive ability of AB for relapse is not robust. One reason for this might be fluctuations of AB due to stress. Therefore, the current study investigated whether AB was present during and after stress induction and whether AB was enhanced by stress induction. METHODS: A Virtual Reality (VR) adaptation of the Trier Social Stress Test (VR-TSST) was used to induce psychosocial stress in smokers ( n  = 34) and non-smokers ( n  = 37) followed by a novel free-viewing task in VR...
2023: Frontiers in Psychology
https://read.qxmd.com/read/37059028/post-error-slowing-predicts-for-relapse-in-individuals-with-alcohol-use-disorder
#12
JOURNAL ARTICLE
Duanwei Wang, Yuanyuan Yin, Wei Yuan, Bin Li, Hairong Wang, Ji Hu, Meng Chen, Yuandong Gong, Ti-Fei Yuan, Tiangui Yu
BACKGROUND: Relapse characterizes addiction. The cognitive phenotype underlying relapse in individuals with alcohol use disorder (AUD) remain unelucidated. Here we aimed to investigate the potential changes in behavioral adjustment in AUD, and the association with relapse. METHOD: Forty-seven subjects with AUD at Shandong Mental Health Center completed the stop-signal task, the PACS, the Beck Depression Inventory and the State-Trait anxiety questionnaires. Thirty age-matched male healthy subjects served as the control group (HC)...
April 5, 2023: Journal of Psychiatric Research
https://read.qxmd.com/read/37048769/psychosocial-factors-affecting-drug-relapse-among-youth-in-punjab-pakistan
#13
JOURNAL ARTICLE
Najma Iqbal Malik, Sidra Saleem, Irfan Ullah, Syeda Tayyaba Rehan, Domenico De Berardis, Mohsin Atta
The present study was intended to examine the effect of psychosocial factors on the stigma of mental illness among people addicted to drugs who have relapsed in Punjab, Pakistan. A sample composed of 116 people addicted to drugs and who have relapsed was collected through the purposive sampling technique. Certain self-report measures were used to assess the pertinent study variables. The results elucidated that self-efficacy, social support, and conscientiousness were found to be negative predictors and neuroticism a positive predictor of stigma...
April 4, 2023: Journal of Clinical Medicine
https://read.qxmd.com/read/37009164/examining-within-and-between-person-facets-of-negative-affect-and-associations-with-daily-craving-among-young-adults-in-substance-use-disorder-recovery
#14
JOURNAL ARTICLE
Shou-Chun Chiang, Kyler S Knapp, Sunhye Bai, H Harrington Cleveland, Kitty S Harris
The role of negative affect in precipitating drug craving and relapse among young adults in recovery from substance use disorder (SUD) is well documented. However, most studies focus on negative affect as a trait-level congregate of multiple negative emotion states. The present study examined the associations between specific facets of negative affect, college stressors, and craving among young adult college students in SUD recovery. Data were drawn from a three-week daily diary study of 50 students participating in a collegiate recovery community at a U...
2023: Addiction Research & Theory
https://read.qxmd.com/read/36970276/animal-studies-reveal-that-the-ghrelin-pathway-regulates-alcohol-mediated-responses
#15
Elisabet Jerlhag
Alcohol use disorder (AUD) is often described as repeated phases of binge drinking, compulsive alcohol-taking, craving for alcohol during withdrawal, and drinking with an aim to a reduce the negative consequences. Although multifaceted, alcohol-induced reward is one aspect influencing the former three of these. The neurobiological mechanisms regulating AUD processes are complex and one of these systems is the gut-brain peptide ghrelin. The vast physiological properties of ghrelin are mediated via growth hormone secretagogue receptor (GHSR, ghrelin receptor)...
2023: Frontiers in Psychiatry
https://read.qxmd.com/read/36790830/the-impact-of-life-satisfaction-in-the-treatment-of-gaming-disorder-and-other-internet-use-disorders-results-from-a-randomized-controlled-trial
#16
JOURNAL ARTICLE
Kai W Müller, Michael Dreier, Manfred E Beutel, Christian Ruckes, Anil Batra, Karl Mann, Michael Musalek, Klaus Wölfling
OBJECTIVE: According to ICD-11 gaming disorder is currently defined as a behavioral addiction. While our understanding of crucial aspects of this new condition including other subtypes of internet use disorders is growing, less is known about treatment strategies and their effectiveness. Particularly, dimensions of life satisfaction and their meaning for internet use disorders are poorly investigated. The aim of this study was addressing the role of life satisfaction dimensions in a randomized controlled trial...
February 14, 2023: Journal of Behavioral Addictions
https://read.qxmd.com/read/36635246/basal-forebrain-chemogenetic-inhibition-converts-the-attentional-control-mode-of-goal-trackers-to-that-of-sign-trackers
#17
JOURNAL ARTICLE
Aaron Kucinski, Cassandra Avila, Martin Sarter
Sign tracking versus goal tracking in rats indicate vulnerability and resistance, respectively, to Pavlovian cue-evoked addictive drug taking and relapse. Here, we tested hypotheses predicting that the opponent cognitive-behavioral styles indexed by sign tracking versus goal tracking include variations in attentional performance which differentially depend on basal forebrain projection systems. Pavlovian Conditioned Approach (PCA) testing was used to identify male and female sign-trackers (STs) and goal-trackers (GTs), as well as rats with an intermediate phenotype (INTs)...
2022: ENeuro
https://read.qxmd.com/read/36564531/corticotropin-releasing-factor-receptor-1-crf1-antagonism-in-patients-with-alcohol-use-disorder-and-high-anxiety-levels-effect-on-neural-response-during-trier-social-stress-test-video-feedback
#18
JOURNAL ARTICLE
Mary R Lee, Daniel Rio, Laura Kwako, David T George, Markus Heilig, Reza Momenan
In preclinical models of alcohol use disorder, the corticotropin-releasing factor (CRF) receptor is upregulated, particularly in the extended amygdala. This upregulation is thought to play a role in stress-induced relapse to drinking by a mechanism that is independent of the hypothalamic-pituitary-adrenal axis. As part of a double-blind, placebo-controlled clinical study with pexacerfont, a selective, orally available, and brain-penetrant CRF1 receptor antagonist which has anti-anxiety effects in preclinical studies, we examined the effect of pexacerfont on the neural response to a social stress task adapted to fMRI...
December 23, 2022: Neuropsychopharmacology
https://read.qxmd.com/read/36359247/the-executive-functioning-paradox-in-substance-use-disorders
#19
JOURNAL ARTICLE
Louise Jakubiec, Valentine Chirokoff, Majd Abdallah, Ernesto Sanz-Arigita, Maud Dupuy, Joel Swendsen, Sylvie Berthoz, Fabien Gierski, Sarah Guionnet, David Misdrahi, Fuschia Serre, Marc Auriacombe, Melina Fatseas
Deficits in neurocognitive functioning are trait-like vulnerabilities that have been widely studied in persons with substance use disorders (SUD), but their role in the craving-use association and relapse vulnerability remains poorly understood. The main objectives of this study were to examine whether executive capacities moderate the magnitude of the craving-substance use relationship, and if this influence is correlated with the functional connectivity of cerebral networks, combining rsfMRI examinations and ecological momentary assessment (EMA)...
October 28, 2022: Biomedicines
https://read.qxmd.com/read/36170176/personality-traits-and-their-role-as-risk-modifiers-in-gaming-disorder-and-internet-use-disorders
#20
JOURNAL ARTICLE
Kai W Müller, Michael Dreier, Klaus Wölfling
PURPOSE OF REVIEW: After its initial recognition in the DSM-5, Gaming Disorder has now officially been included as a mental disorder in the ICD-11 as a behavioral addiction. In the past decades, research on this phenomenon has increased and in particular theories on its etiopathology have been suggested. In that respect, underlying factors, including neurobiological, social, and psychological factors, have been described. One commonly discussed etiological factor is supposed in specific personality traits...
September 29, 2022: Current Opinion in Psychiatry
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