Loris Busch, Anna Maria Hanuschik, Yuri Avlasevich, Katrin Darm, Elisa F Hochheiser, Christian Kohler, Evgeny A Idelevich, Karsten Becker, Peter Rotsch, Katharina Landfester, Maxim E Darvin, Martina C Meinke, Cornelia M Keck, Axel Kramer, Paula Zwicker
Hair follicles constitute important drug delivery targets for skin antisepsis since they contain ≈25% of the skin microbiome. Nanoparticles are known to penetrate deeply into hair follicles. By massaging the skin, the follicular penetration process is enhanced based on a ratchet effect. Subsequently, an intrafollicular drug release can be initiated by various trigger mechanisms. Here, we present novel ultraviolet A (UVA)-responsive nanocapsules (NCs) with a size between 400 and 600 nm containing hydroxyethyl starch (HES) functionalized by an o -nitrobenzyl linker...
February 11, 2023: Pharmaceutics