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Skin antisepsis

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https://www.readbyqxmd.com/read/29600816/comparison-of-chlorhexidine-isopropanol-with-isopropanol-skin-antisepsis-for-prevention-of-surgical-site-infection-after-abdominal-surgery
#1
J C Harnoss, O Assadian, A Kramer, P Probst, C Müller-Lantzsch, L Scheerer, T Bruckner, M K Diener, M W Büchler, A B Ulrich
BACKGROUND: Prevention of surgical-site infection (SSI) has received increasing attention. Clinical trials have focused on the role of skin antisepsis in preventing SSI. The benefit of combining antiseptic chlorhexidine with alcohol has not been compared with alcohol-based skin preparation alone in a prospective controlled clinical trial. METHODS: Between August and October 2014, patients undergoing abdominal surgery received preoperative skin antisepsis with 70 per cent isopropanol (PA)...
March 30, 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29580742/propionibacterium-acnes-persists-despite-various-skin-preparation-techniques
#2
Nathanael Heckmann, Lakshmanan Sivasundaram, K Soraya Heidari, Alexander E Weber, Erik N Mayer, Reza Omid, C Thomas Vangsness, George F Hatch
PURPOSE: To investigate the efficacy of various skin preparations at eradicating Propionibacterium acnes in the dermal layer of the skin. METHODS: Twelve healthy volunteers consented to participate in this study. Each subject's upper back was prepped using 4 different techniques: an isopropyl alcohol control, chlorhexidine gluconate paint, chlorhexidine gluconate plus a mechanical scrub, and a high-concentration chlorhexidine gluconate plus a mechanical scrub. A 3-mm dermal punch biopsy specimen was obtained at each preparation site...
March 23, 2018: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29574175/developing-process-maps-as-a-tool-for-a-surgical-infection-prevention-quality-improvement-initiative-in-resource-constrained-settings
#3
Jared A Forrester, Luca A Koritsanszky, Demisew Amenu, Alex B Haynes, William R Berry, Seifu Alemu, Fekadu Jiru, Thomas G Weiser
BACKGROUND: Surgical infections cause substantial morbidity and mortality in low-and middle-income countries (LMICs). To improve adherence to critical perioperative infection prevention standards, we developed Clean Cut, a checklist-based quality improvement program to improve compliance with best practices. We hypothesized that process mapping infection prevention activities can help clinicians identify strategies for improving surgical safety. STUDY DESIGN: We introduced Clean Cut at a tertiary hospital in Ethiopia...
March 21, 2018: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/29425078/pre-operative-skin-antisepsis-with-chlorhexidine-gluconate-and-povidone-iodine-to-prevent-port-site-infection-in-laparoscopic-cholecystectomy-a-prospective-study
#4
Erasmo Spaziani, Annalisa Di Filippo, Simone Orelli, Flavia Fiorini, Martina Spaziani, Orlando Tintisona, Angelo Torcasio, Alessandro De Cesare, Marcello Picchio
BACKGROUND: Skin preparation with antiseptic agents is commonly recommended for incisional site cleansing before surgery. We present the result of a prospective case series submitted to a scheduled pre-operative antiseptic procedure combining chlorhexidine gluconate and povidone-iodine before elective laparoscopic cholecystectomy. PATIENTS AND METHODS: Consecutive patients underwent pre-operative standardized cleansing of the operation site combining chlorhexidine gluconate and povidone-iodine...
April 2018: Surgical Infections
https://www.readbyqxmd.com/read/29398812/evaluation-of-the-role-of-novel-aprotic-dimethyl-sulfoxide-in-cutaneous-antisepsis-protocols-prior-to-blood-donor-phlebotomy-with-isopropyl-alcohol-povidone-iodine-or-chlorhexidine
#5
Suchet Sachdev, Nandini Sethuraman, Vikas Gautam, Deepak Pahwa, Anuradha Kalra, Ratti Ram Sharma, Neelam Marwaha, Pallab Ray
The study was planned to measure the reduction of the load of bacterial flora on the blood donor's arm quantitatively using a three step protocol of donor arm cleansing incorporating either 70% isopropyl alcohol (IPA) or 5% w/v povidone iodine (PVI, 0.5% w/v available iodine) or 4% chlorhexidine gluconate (CHG) with or without the addition of 5% dimethyl sufloxide (DMSO). Single blind randomized study after obtaining ethical clearance, using the Miles and Misra technique for quantification and matrix assisted laser desorption ionization-mass spectrometry for identification of colony morphotypes on blood donor's skin...
January 2018: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/29283367/surveillance-of-environmental-and-procedural-measures-of-infection-control-in-the-operating-theatre-setting
#6
Laura Dallolio, Alessandra Raggi, Tiziana Sanna, Magda Mazzetti, Alessandra Orsi, Angela Zanni, Patrizia Farruggia, Erica Leoni
The microbiological contamination of operating theatres and the lack of adherence to best practices by surgical staff represent some of the factors affecting Surgical Site Infections (SSIs). The aim of the present study was to assess the microbiological quality of operating settings and the staff compliance to the SSI evidence-based control measures. Ten operating rooms were examined for microbiological contamination of air and surfaces, after cleaning procedures, in "at rest" conditions. Furthermore, 10 surgical operations were monitored to assess staff compliance to the recommended practices...
December 28, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29190159/performance-of-bio-occlusive-dressing-as-barrier-protection-from-presurgical-chlorhexidine-skin-preparation
#7
Frank Brodie, Gregory Bever, David G Hwang
Purpose/Aim of the study: Chlorhexdine has been shown to provide excellent and cost-effective presurgical antisepsis. However, standard presurgical concentrations of chlorhexidine (2-4%) are known to cause ocular injury, even in cases in which a bio-occlusive dressing (Tegaderm™) was applied beforehand to the closed eye. MATERIALS AND METHODS: Three experiments were conducted to assess the barrier performance of Tegaderm™ to chlorhexidine skin prep in vitro and on non-ocular skin...
November 30, 2017: Current Eye Research
https://www.readbyqxmd.com/read/29171793/preoperative-skin-antisepsis-with-chlorhexidine-gluconate-versus-povidone-iodine-a-prospective-analysis-of-6959-consecutive-spinal-surgery-patients
#8
George M Ghobrial, Michael Y Wang, Barth A Green, Howard B Levene, Glen Manzano, Steven Vanni, Robert M Starke, George Jimsheleishvili, Kenneth M Crandall, Marina Dididze, Allan D Levi
OBJECTIVE The aim of this study was to determine the efficacy of 2 common preoperative surgical skin antiseptic agents, ChloraPrep and Betadine, in the reduction of postoperative surgical site infection (SSI) in spinal surgery procedures. METHODS Two preoperative surgical skin antiseptic agents-ChloraPrep (2% chlorhexidine gluconate and 70% isopropyl alcohol) and Betadine (7.5% povidone-iodine solution)-were prospectively compared across 2 consecutive time periods for all consecutive adult neurosurgical spine patients...
February 2018: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/29148002/targeting-zero-catheter-related-bloodstream-infections-in-pediatric-intensive-care-unit-a-retrospective-matched-case-control-study
#9
Daniele G Biasucci, Mauro Pittiruti, Alessandra Taddei, Enzo Picconi, Alessandro Pizza, Davide Celentano, Marco Piastra, Giancarlo Scoppettuolo, Giorgio Conti
INTRODUCTION: The aim of this study was to evaluate the effectiveness and safety of a new three-component 'bundle' for insertion and management of centrally inserted central catheters (CICCs), designed to minimize catheter-related bloodstream infections (CRBSIs) in critically ill children. METHODS: Our 'bundle' has three components: insertion, management, and education. Insertion and management recommendations include: skin antisepsis with 2% chlorhexidine; maximal barrier precautions; ultrasound-guided venipuncture; tunneling of the catheter when a long indwelling time is expected; glue on the exit site; sutureless securement; use of transparent dressing; chlorhexidine sponge dressing on the 7th day; neutral displacement needle-free connectors...
March 2018: Journal of Vascular Access
https://www.readbyqxmd.com/read/29061748/-in-vitro-evaluation-of-povidone-iodine-and-chlorhexidine-against-outbreak-and-nonoutbreak-strains-of-mycobacterium-abscessus-using-standard-quantitative-suspension-and-carrier-testing
#10
Aristine Cheng, Hsin-Yun Sun, Yi-Tzu Tsai, Un-In Wu, Yu-Chung Chuang, Jann-Tay Wang, Wang-Huei Sheng, Po-Ren Hsueh, Yee-Chun Chen, Shan-Chwen Chang
Povidone-iodine (PI) and chlorhexidine (CHX) are widely used antiseptics active against conventional Staphylococcus aureus , Enterobacteriaceae , Candida species, and viruses, but their efficacy against Mycobacterium abscessus remains unproven. We determined the in vitro potency of alcoholic PI and CHX against M. abscessus subsp. abscessus (ATCC 19977), M. abscessus subsp. bolletii (BCRC 16915), and our outbreak strain of M. abscessus subsp. massiliense (TPE 101) in reference to Staphylococcus aureus (ATCC 29213) by standard quantitative suspension and carrier methods (EN 14563)...
January 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29019097/efficacy-of-conventional-and-liposomal-povidone-iodine-in-infected-mesh-skin-grafts-an-exploratory-study
#11
Peter M Vogt, Joerg Hauser, Stefan Mueller, Bjoern Bosse, Michael Hopp
INTRODUCTION: Infection is a major threat to wound healing and a leading cause of graft loss in patients undergoing meshed skin grafts (MSGs). Therefore, topical antisepsis is important in the overall treatment scheme. METHODS: An exploratory satellite group of 14 patients with infected MSGs were enrolled as part of a prospective, randomized, controlled, parallel-group, open-label, pilot Phase II study that investigated the efficacy and tolerability of 3% liposomal povidone-iodine hydrogel (PVP-ILH, Repithel® ; RepiGel® ) versus chlorhexidine gauze in non-infected MSGs...
December 2017: Infectious Diseases and Therapy
https://www.readbyqxmd.com/read/28967509/skin-antisepsis-with-0-05-sodium-hypochlorite-before-central-venous-catheter-insertion-in-neonates-a-2-year-single-center-experience
#12
Matilde Ciccia, Roksana Chakrokh, Dario Molinazzi, Angela Zanni, Patrizia Farruggia, Fabrizio Sandri
AIM: The study reports a 2-year single-center experience of the practice of skin antisepsis using a 0.05% sodium hypochlorite solution before central venous catheter placement in neonates. METHODS: Eligible subjects included any hospitalized neonate who needed a central line for at least 48 hours. Infants were excluded if they had a generalized or localized skin disorder. An ad hoc Excel (Microsoft Corp, Redmond, WA) file was used to record the data from each patient...
September 26, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/28963158/antisepsis-of-the-skin-before-spinal-surgery-with-povidone-iodine-alcohol-followed-by-chlorhexidine-gluconate-alcohol-versus-povidone-iodine-alcohol-applied-twice-for-the-prevention-of-contamination-of-the-wound-by-bacteria-a-randomised-controlled-trial
#13
RANDOMIZED CONTROLLED TRIAL
S Patrick, A McDowell, A Lee, A Frau, U Martin, E Gardner, G McLorinan, N Eames
AIMS: The aim of this study was to determine whether the sequential application of povidone iodine-alcohol (PVI) followed by chlorhexidine gluconate-alcohol (CHG) would reduce surgical wound contamination to a greater extent than PVI applied twice in patients undergoing spinal surgery. PATIENTS AND METHODS: A single-centre, interventional, two arm, parallel group randomised controlled trial was undertaken, involving 407 patients who underwent elective spinal surgery...
October 2017: Bone & Joint Journal
https://www.readbyqxmd.com/read/28948926/who-s-recommendation-for-surgical-skin-antisepsis-is-premature-authors-reply
#14
Benedetta Allegranzi, Matthias Egger, Didier Pittet, Peter Bischoff, Peter Nthumba, Joseph Solomkin
No abstract text is available yet for this article.
October 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28817989/optimal-skin-antiseptic-agents-for-prevention-of-surgical-site-infection-in-cesarean-section-a-meta-analysis-with-trial-sequential-analysis
#15
Huaping Huang, Guirong Li, Haiyan Wang, Mei He
PURPOSE: The best choice of antiseptic agent for skin preparation at cesarean section remains controversial. We performed this meta-analysis to assess whether chlorhexidine (CH)-based skin antisepsis was more effective than povidone iodine (PI)-based antisepsis for the prevention of surgical site infection (SSI) after cesarean section. METHODS: PubMed, EMBASE, and the Cochrane Library were systematically searched to identify English publications that compared chlorhexidine gluconate (CH) as a skin preparation agent with PI in cesarean section...
August 30, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28811083/phenotypic-chlorhexidine-and-triclosan-susceptibility-in-clinical-staphylococcus-aureus-isolates-in-australia
#16
C Hughes, J Ferguson
Antiseptics such as chlorhexidine gluconate and triclosan are widely used in healthcare settings for both skin antisepsis and decolonisation of Staphylococcus aureus. We determined the minimum inhibitory concentration (MIC) of 198 methicillin susceptible and resistant Staphylococcus aureus clinical isolates to both chlorhexidine and triclosan using an agar dilution method. Of these, 10% (19/198) showed a raised MIC to chlorhexidine and 3% (6/198) showed an elevated MIC to triclosan. The multilocus sequence type (MLST) of each isolate was predicted using a binary method, and although ST93-MRSA-IV was the most common, ST22-MRSA-IV was shown to have statistically higher chlorhexidine MIC values compared with non ST22-MRSA-IV isolates (z = -8...
August 12, 2017: Pathology
https://www.readbyqxmd.com/read/28790056/alcoholic-versus-aqueous-chlorhexidine-for-skin-antisepsis-the-avalanche-trial
#17
RANDOMIZED CONTROLLED TRIAL
Daniel Charles, Clare F Heal, Meth Delpachitra, Michael Wohlfahrt, Debbie Kimber, Julie Sullivan, Sheldon Browning, Sabine Saednia, Alexandra Hardy, Jennifer Banks, Petra Buttner
BACKGROUND: Preoperative skin antisepsis is routine practice. We compared alcoholic chlorhexidine with aqueous chlorhexidine for skin antisepsis to prevent surgical site infection after minor skin excisions in general practice. METHODS: We conducted this prospective, multicentre, randomized controlled trial in 4 private general practices in North Queensland, Australia, from October 2015 to August 2016. Consecutive adult patients presenting for minor skin excisions were randomly assigned to undergo preoperative skin antisepsis with 0...
August 8, 2017: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
https://www.readbyqxmd.com/read/28768592/effect-of-hand-lotion-on-the-effectiveness-of-hygienic-hand-antisepsis-implications-for-practicing-hand-hygiene
#18
Helga Paula, Nils-Olaf Hübner, Ojan Assadian, Katja Bransmöller, Romy Baguhl, Harald Löffler, Axel Kramer
BACKGROUND: Skin protection products should be used after washing hands with soap, during breaks, after work, and during leisure time. Aside from their beneficial effects, skin care products may also interact with alcohol-based hand disinfectants by reducing their efficacy. The aim of this study was to investigate the effect of a hand lotion on the effectiveness of hygienic hand antisepsis using an alcohol-based handrub. METHODS: The effect of a protective hand lotion against an isopropyl alcohol-based handrub was investigated in 20 healthy volunteers according to the European standard test procedure EN 1500 in the following combinations: handwashing and application of hand lotion, only application of hand lotion, and no washing and no hand lotion (control), each for 5 minutes or 1 hour before hand antisepsis...
August 1, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/28697103/chlorhexidine-alcohol-compared-with-povidone-iodine-for-preoperative-topical-antisepsis-for-abdominal-hysterectomy
#19
COMPARATIVE STUDY
Shitanshu Uppal, Ali Bazzi, R Kevin Reynolds, John Harris, Mark D Pearlman, Darrell A Campbell, Daniel M Morgan
OBJECTIVE: To compare preoperative chlorhexidine-alcohol topical antiseptic agent with povidone-iodine in patients undergoing abdominal hysterectomy for benign indications. METHODS: A retrospective cohort study of patients undergoing abdominal hysterectomy from July 2012 to February 2015 in the Michigan Surgical Quality Collaborative was performed. The primary exposure was the use of chlorhexidine-alcohol or povidone-iodine. The primary outcome was surgical site infection within 30 days...
August 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28601567/impact-of-evidence-based-interventions-on-wound-complications-after-cesarean-delivery
#20
RANDOMIZED CONTROLLED TRIAL
Lorene A Temming, Nandini Raghuraman, Ebony B Carter, Molly J Stout, Roxane M Rampersad, George A Macones, Alison G Cahill, Methodius G Tuuli
BACKGROUND: A number of evidence-based interventions have been proposed to reduce post-cesarean delivery wound complications. Examples of such interventions include appropriate timing of preoperative antibiotics, appropriate choice of skin antisepsis, closure of the subcutaneous layer if subcutaneous depth is ≥2 cm, and subcuticular skin closure with suture rather than staples. However, the collective impact of these measures is unclear. OBJECTIVE: We sought to estimate the impact of a group of evidence-based surgical measures (prophylactic antibiotics administered before skin incision, chlorhexidine-alcohol for skin antisepsis, closure of subcutaneous layer, and subcuticular skin closure with suture) on wound complications after cesarean delivery and to estimate residual risk factors for wound complications...
October 2017: American Journal of Obstetrics and Gynecology
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