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Skin antisepsis

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https://www.readbyqxmd.com/read/29884793/skin-microbiota-in-obese-women-at-risk-for-surgical-site-infection-after-cesarean-delivery
#1
Kara M Rood, Irina A Buhimschi, Joseph A Jurcisek, Taryn L Summerfield, Guomao Zhao, William E Ackerman, Weiwei Wang, R Wolfgang Rumpf, Stephen F Thung, Lauren O Bakaletz, Catalin S Buhimschi
The obesity pandemic in the obstetrical population plus increased frequency of Cesarean delivery (CD) has increased vulnerability to surgical site infection (SSI). Here we characterized the microbiome at the site of skin incision before and after CD. Skin and relevant surgical sites were sampled before and after surgical antisepsis from obese (n = 31) and non-obese (n = 27) pregnant women. We quantified bacterial biomass by qPCR, microbial community composition by 16sRNA sequencing, assigned operational taxonomic units, and stained skin biopsies from incision for bacteria and biofilms...
June 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29849365/tibial-osteomyelitis-following-prehospital-intraosseous-access
#2
Derek Yee, Rahul Deolankar, Jodie Marcantoni, Stephen Y Liang
Intraosseous (IO) access is a lifesaving alternative to peripheral or central venous access in emergency care. However, emergency physicians and prehospital care providers must be aware of the potential for infectious complications associated with this intervention. We describe the case of a HIV-negative, otherwise immunocompetent adult patient who underwent prehospital insertion of a tibial IO device. Following successful resuscitation, the patient developed tibial osteomyelitis requiring multiple operative debridements, soft tissue coverage, and several courses of prolonged antimicrobial therapy...
November 2017: Clinical practice and cases in emergency medicine
https://www.readbyqxmd.com/read/29847418/a-prospective-comparative-study-in-skin-antiseptic-solutions-for-posterior-spine-surgeries-chlorhexidine-gluconate-ethanol-versus-povidone-iodine
#3
Toshitaka Yoshii, Takashi Hirai, Tsuyoshi Yamada, Kenichiro Sakai, Shuta Ushio, Satoru Egawa, Masato Yuasa, Tsuyoshi Kato, Hiroyuki Inose, Shigenori Kawabata, Atsushi Okawa
STUDY DESIGN: This is a prospective comparative study. OBJECTIVE: We evaluated the efficacy of 2 standard antiseptic solutions, chlorhexidine-gluconate (CHG) and povidone-iodine (PD-I), in eliminating bacterial pathogens from surgical sites in posterior spine surgeries. SUMMARY OF BACKGROUND DATA: Previous studies have shown that CHG is more effective for skin antisepsis than PD-I in joint surgeries. However, few studies have investigated the preoperative use of antiseptic solutions in spine surgery...
May 25, 2018: Clinical Spine Surgery
https://www.readbyqxmd.com/read/29791701/microbial-load-of-trocars-potential-source-of-contamination-and-surgical-site-infection
#4
Vanessa Aparecida Vilas-Boas, Carlos Emílio Levy, Maria Isabel Pedreira de Freitas, Kevin Woo
Surgical site infection (SSI) is a common complication that is associated with delayed recovery, prolonged length of hospital stay, exorbitant cost, and mortality. The present prospective longitudinal study aimed to evaluate the relationships between the microbial load of trocars used in laparoscopic gynecological surgery, microbiota in surgical sites, and SSI. The final sample consisted of 24 patients, including 68 swab samples and 48 trocars. Microorganisms were recovered in 100.0% of the swabs collected from the umbilicus and vaginal fornix and in 58...
June 1, 2018: Surgical Technology International
https://www.readbyqxmd.com/read/29782437/skin-injuries-and-chlorhexidine-gluconate-based-antisepsis-in-early-premature-infants-a-case-report-and-review-of-the-literature
#5
Valentina Vanzi, Rosanna Pitaro
Early premature infants are subjected to many invasive procedures in neonatal intensive care units, and effective skin antisepsis is an essential step in caring for these vulnerable patients. Nevertheless, preterm infants have an anatomically and physiologically immature skin and preserving their skin integrity is essential to avoid the risk of local and systemic complications. Skin particularities of newborns reduce the list of available antiseptics in neonatology. Chlorhexidine gluconate (CHG) has excellent antiseptic properties and its antimicrobial efficacy cannot be understated, but there is great concern about its use for premature infants, referring to the risk of development skin injuries, such as skin erythema, burns, and blisters...
May 17, 2018: Journal of Perinatal & Neonatal Nursing
https://www.readbyqxmd.com/read/29600816/comparison-of-chlorhexidine-isopropanol-with-isopropanol-skin-antisepsis-for-prevention-of-surgical-site-infection-after-abdominal-surgery
#6
J C Harnoss, O Assadian, A Kramer, P Probst, C Müller-Lantzsch, L Scheerer, T Bruckner, M K Diener, M W Büchler, A B Ulrich
BACKGROUND: Prevention of surgical-site infection (SSI) has received increasing attention. Clinical trials have focused on the role of skin antisepsis in preventing SSI. The benefit of combining antiseptic chlorhexidine with alcohol has not been compared with alcohol-based skin preparation alone in a prospective controlled clinical trial. METHODS: Between August and October 2014, patients undergoing abdominal surgery received preoperative skin antisepsis with 70 per cent isopropanol (PA)...
June 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29580742/propionibacterium-acnes-persists-despite-various-skin-preparation-techniques
#7
Nathanael Heckmann, Lakshmanan Sivasundaram, K Soraya Heidari, Alexander E Weber, Erik N Mayer, Reza Omid, C Thomas Vangsness, George F Hatch
PURPOSE: To investigate the efficacy of various skin preparations at eradicating Propionibacterium acnes in the dermal layer of the skin. METHODS: Twelve healthy volunteers consented to participate in this study. Each subject's upper back was prepped using 4 different techniques: an isopropyl alcohol control, chlorhexidine gluconate paint, chlorhexidine gluconate plus a mechanical scrub, and a high-concentration chlorhexidine gluconate plus a mechanical scrub. A 3-mm dermal punch biopsy specimen was obtained at each preparation site...
June 2018: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29574175/developing-process-maps-as-a-tool-for-a-surgical-infection-prevention-quality-improvement-initiative-in-resource-constrained-settings
#8
Jared A Forrester, Luca A Koritsanszky, Demisew Amenu, Alex B Haynes, William R Berry, Seifu Alemu, Fekadu Jiru, Thomas G Weiser
BACKGROUND: Surgical infections cause substantial morbidity and mortality in low-and middle-income countries (LMICs). To improve adherence to critical perioperative infection prevention standards, we developed Clean Cut, a checklist-based quality improvement program to improve compliance with best practices. We hypothesized that process mapping infection prevention activities can help clinicians identify strategies for improving surgical safety. STUDY DESIGN: We introduced Clean Cut at a tertiary hospital in Ethiopia...
June 2018: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/29425078/pre-operative-skin-antisepsis-with-chlorhexidine-gluconate-and-povidone-iodine-to-prevent-port-site-infection-in-laparoscopic-cholecystectomy-a-prospective-study
#9
Erasmo Spaziani, Annalisa Di Filippo, Simone Orelli, Flavia Fiorini, Martina Spaziani, Orlando Tintisona, Angelo Torcasio, Alessandro De Cesare, Marcello Picchio
BACKGROUND: Skin preparation with antiseptic agents is commonly recommended for incisional site cleansing before surgery. We present the result of a prospective case series submitted to a scheduled pre-operative antiseptic procedure combining chlorhexidine gluconate and povidone-iodine before elective laparoscopic cholecystectomy. PATIENTS AND METHODS: Consecutive patients underwent pre-operative standardized cleansing of the operation site combining chlorhexidine gluconate and povidone-iodine...
April 2018: Surgical Infections
https://www.readbyqxmd.com/read/29398812/evaluation-of-the-role-of-novel-aprotic-dimethyl-sulfoxide-in-cutaneous-antisepsis-protocols-prior-to-blood-donor-phlebotomy-with-isopropyl-alcohol-povidone-iodine-or-chlorhexidine
#10
Suchet Sachdev, Nandini Sethuraman, Vikas Gautam, Deepak Pahwa, Anuradha Kalra, Ratti Ram Sharma, Neelam Marwaha, Pallab Ray
The study was planned to measure the reduction of the load of bacterial flora on the blood donor's arm quantitatively using a three step protocol of donor arm cleansing incorporating either 70% isopropyl alcohol (IPA) or 5% w/v povidone iodine (PVI, 0.5% w/v available iodine) or 4% chlorhexidine gluconate (CHG) with or without the addition of 5% dimethyl sufloxide (DMSO). Single blind randomized study after obtaining ethical clearance, using the Miles and Misra technique for quantification and matrix assisted laser desorption ionization-mass spectrometry for identification of colony morphotypes on blood donor's skin...
January 2018: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/29283367/surveillance-of-environmental-and-procedural-measures-of-infection-control-in-the-operating-theatre-setting
#11
Laura Dallolio, Alessandra Raggi, Tiziana Sanna, Magda Mazzetti, Alessandra Orsi, Angela Zanni, Patrizia Farruggia, Erica Leoni
The microbiological contamination of operating theatres and the lack of adherence to best practices by surgical staff represent some of the factors affecting Surgical Site Infections (SSIs). The aim of the present study was to assess the microbiological quality of operating settings and the staff compliance to the SSI evidence-based control measures. Ten operating rooms were examined for microbiological contamination of air and surfaces, after cleaning procedures, in "at rest" conditions. Furthermore, 10 surgical operations were monitored to assess staff compliance to the recommended practices...
December 28, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29190159/performance-of-bio-occlusive-dressing-as-barrier-protection-from-presurgical-chlorhexidine-skin-preparation
#12
Frank Brodie, Gregory Bever, David G Hwang
Purpose/Aim of the study: Chlorhexdine has been shown to provide excellent and cost-effective presurgical antisepsis. However, standard presurgical concentrations of chlorhexidine (2-4%) are known to cause ocular injury, even in cases in which a bio-occlusive dressing (Tegaderm™) was applied beforehand to the closed eye. MATERIALS AND METHODS: Three experiments were conducted to assess the barrier performance of Tegaderm™ to chlorhexidine skin prep in vitro and on non-ocular skin...
May 2018: Current Eye Research
https://www.readbyqxmd.com/read/29171793/preoperative-skin-antisepsis-with-chlorhexidine-gluconate-versus-povidone-iodine-a-prospective-analysis-of-6959-consecutive-spinal-surgery-patients
#13
George M Ghobrial, Michael Y Wang, Barth A Green, Howard B Levene, Glen Manzano, Steven Vanni, Robert M Starke, George Jimsheleishvili, Kenneth M Crandall, Marina Dididze, Allan D Levi
OBJECTIVE The aim of this study was to determine the efficacy of 2 common preoperative surgical skin antiseptic agents, ChloraPrep and Betadine, in the reduction of postoperative surgical site infection (SSI) in spinal surgery procedures. METHODS Two preoperative surgical skin antiseptic agents-ChloraPrep (2% chlorhexidine gluconate and 70% isopropyl alcohol) and Betadine (7.5% povidone-iodine solution)-were prospectively compared across 2 consecutive time periods for all consecutive adult neurosurgical spine patients...
February 2018: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/29148002/targeting-zero-catheter-related-bloodstream-infections-in-pediatric-intensive-care-unit-a-retrospective-matched-case-control-study
#14
Daniele G Biasucci, Mauro Pittiruti, Alessandra Taddei, Enzo Picconi, Alessandro Pizza, Davide Celentano, Marco Piastra, Giancarlo Scoppettuolo, Giorgio Conti
INTRODUCTION: The aim of this study was to evaluate the effectiveness and safety of a new three-component 'bundle' for insertion and management of centrally inserted central catheters (CICCs), designed to minimize catheter-related bloodstream infections (CRBSIs) in critically ill children. METHODS: Our 'bundle' has three components: insertion, management, and education. Insertion and management recommendations include: skin antisepsis with 2% chlorhexidine; maximal barrier precautions; ultrasound-guided venipuncture; tunneling of the catheter when a long indwelling time is expected; glue on the exit site; sutureless securement; use of transparent dressing; chlorhexidine sponge dressing on the 7th day; neutral displacement needle-free connectors...
March 2018: Journal of Vascular Access
https://www.readbyqxmd.com/read/29061748/-in-vitro-evaluation-of-povidone-iodine-and-chlorhexidine-against-outbreak-and-nonoutbreak-strains-of-mycobacterium-abscessus-using-standard-quantitative-suspension-and-carrier-testing
#15
Aristine Cheng, Hsin-Yun Sun, Yi-Tzu Tsai, Un-In Wu, Yu-Chung Chuang, Jann-Tay Wang, Wang-Huei Sheng, Po-Ren Hsueh, Yee-Chun Chen, Shan-Chwen Chang
Povidone-iodine (PI) and chlorhexidine (CHX) are widely used antiseptics active against conventional Staphylococcus aureus , Enterobacteriaceae , Candida species, and viruses, but their efficacy against Mycobacterium abscessus remains unproven. We determined the in vitro potency of alcoholic PI and CHX against M. abscessus subsp. abscessus (ATCC 19977), M. abscessus subsp. bolletii (BCRC 16915), and our outbreak strain of M. abscessus subsp. massiliense (TPE 101) in reference to Staphylococcus aureus (ATCC 29213) by standard quantitative suspension and carrier methods (EN 14563)...
January 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29019097/efficacy-of-conventional-and-liposomal-povidone-iodine-in-infected-mesh-skin-grafts-an-exploratory-study
#16
Peter M Vogt, Joerg Hauser, Stefan Mueller, Bjoern Bosse, Michael Hopp
INTRODUCTION: Infection is a major threat to wound healing and a leading cause of graft loss in patients undergoing meshed skin grafts (MSGs). Therefore, topical antisepsis is important in the overall treatment scheme. METHODS: An exploratory satellite group of 14 patients with infected MSGs were enrolled as part of a prospective, randomized, controlled, parallel-group, open-label, pilot Phase II study that investigated the efficacy and tolerability of 3% liposomal povidone-iodine hydrogel (PVP-ILH, Repithel® ; RepiGel® ) versus chlorhexidine gauze in non-infected MSGs...
December 2017: Infectious Diseases and Therapy
https://www.readbyqxmd.com/read/28967509/skin-antisepsis-with-0-05-sodium-hypochlorite-before-central-venous-catheter-insertion-in-neonates-a-2-year-single-center-experience
#17
Matilde Ciccia, Roksana Chakrokh, Dario Molinazzi, Angela Zanni, Patrizia Farruggia, Fabrizio Sandri
AIM: The study reports a 2-year single-center experience of the practice of skin antisepsis using a 0.05% sodium hypochlorite solution before central venous catheter placement in neonates. METHODS: Eligible subjects included any hospitalized neonate who needed a central line for at least 48 hours. Infants were excluded if they had a generalized or localized skin disorder. An ad hoc Excel (Microsoft Corp, Redmond, WA) file was used to record the data from each patient...
February 2018: American Journal of Infection Control
https://www.readbyqxmd.com/read/28963158/antisepsis-of-the-skin-before-spinal-surgery-with-povidone-iodine-alcohol-followed-by-chlorhexidine-gluconate-alcohol-versus-povidone-iodine-alcohol-applied-twice-for-the-prevention-of-contamination-of-the-wound-by-bacteria-a-randomised-controlled-trial
#18
RANDOMIZED CONTROLLED TRIAL
S Patrick, A McDowell, A Lee, A Frau, U Martin, E Gardner, G McLorinan, N Eames
AIMS: The aim of this study was to determine whether the sequential application of povidone iodine-alcohol (PVI) followed by chlorhexidine gluconate-alcohol (CHG) would reduce surgical wound contamination to a greater extent than PVI applied twice in patients undergoing spinal surgery. PATIENTS AND METHODS: A single-centre, interventional, two arm, parallel group randomised controlled trial was undertaken, involving 407 patients who underwent elective spinal surgery...
October 2017: Bone & Joint Journal
https://www.readbyqxmd.com/read/28948926/who-s-recommendation-for-surgical-skin-antisepsis-is-premature-authors-reply
#19
Benedetta Allegranzi, Matthias Egger, Didier Pittet, Peter Bischoff, Peter Nthumba, Joseph Solomkin
No abstract text is available yet for this article.
October 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28817989/optimal-skin-antiseptic-agents-for-prevention-of-surgical-site-infection-in-cesarean-section-a-meta-analysis-with-trial-sequential-analysis
#20
Huaping Huang, Guirong Li, Haiyan Wang, Mei He
PURPOSE: The best choice of antiseptic agent for skin preparation at cesarean section remains controversial. We performed this meta-analysis to assess whether chlorhexidine (CH)-based skin antisepsis was more effective than povidone iodine (PI)-based antisepsis for the prevention of surgical site infection (SSI) after cesarean section. METHODS: PubMed, EMBASE, and the Cochrane Library were systematically searched to identify English publications that compared chlorhexidine gluconate (CH) as a skin preparation agent with PI in cesarean section...
August 30, 2017: Journal of Maternal-fetal & Neonatal Medicine
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