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Povidone iodine versus chlorhexidine

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https://www.readbyqxmd.com/read/29171793/preoperative-skin-antisepsis-with-chlorhexidine-gluconate-versus-povidone-iodine-a-prospective-analysis-of-6959-consecutive-spinal-surgery-patients
#1
George M Ghobrial, Michael Y Wang, Barth A Green, Howard B Levene, Glen Manzano, Steven Vanni, Robert M Starke, George Jimsheleishvili, Kenneth M Crandall, Marina Dididze, Allan D Levi
OBJECTIVE The aim of this study was to determine the efficacy of 2 common preoperative surgical skin antiseptic agents, ChloraPrep and Betadine, in the reduction of postoperative surgical site infection (SSI) in spinal surgery procedures. METHODS Two preoperative surgical skin antiseptic agents-ChloraPrep (2% chlorhexidine gluconate and 70% isopropyl alcohol) and Betadine (7.5% povidone-iodine solution)-were prospectively compared across 2 consecutive time periods for all consecutive adult neurosurgical spine patients...
November 24, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/29165561/evaluation-of-short-exposure-times-of-antimicrobial-wound-solutions-against-microbial-biofilms-from-in-vitro-to-in-vivo
#2
K Johani, M Malone, S O Jensen, H G Dickson, I B Gosbell, H Hu, Q Yang, G Schultz, K Vickery
Objectives: Test the performance of topical antimicrobial wound solutions against microbial biofilms using in vitro, ex vivo and in vivo model systems at clinically relevant exposure times. Methods: Topical antimicrobial wound solutions were tested under three different conditions: (in vitro) 4% w/v Melaleuca oil, polyhexamethylene biguanide, chlorhexidine, povidone iodine and hypochlorous acid were tested at short duration exposure times for 15 min against 3 day mature biofilms of Staphylococcus aureus and Pseudomonas aeruginosa; (ex vivo) hypochlorous acid was tested in a porcine skin explant model with 12 cycles of 10 min exposure, over 24 h, against 3 day mature P...
November 18, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29074717/2-chlorhexidine-70-isopropyl-alcohol-versus-10-povidone-iodine-for-insertion-site-cleaning-before-central-line-insertion-in-preterm-infants-a-randomised-trial
#3
Emily A Kieran, Anne O'Sullivan, Jan Miletin, Anne R Twomey, Susan J Knowles, Colm Patrick Finbarr O'Donnell
OBJECTIVE: To determine whether 2% chlorhexidine gluconate-70% isopropyl alcohol (CHX-IA) is superior to 10% aqueous povidone-iodine (PI) in preventing catheter-related blood stream infection (CR-BSI) when used to clean insertion sites before placing central venous catheters (CVCs) in preterm infants. DESIGN: Randomised controlled trial. SETTING: Two neonatal intensive care units (NICUs). PATIENTS: Infants <31 weeks' gestation who had a CVC inserted...
October 26, 2017: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/29019097/efficacy-of-conventional-and-liposomal-povidone-iodine-in-infected-mesh-skin-grafts-an-exploratory-study
#4
Peter M Vogt, Joerg Hauser, Stefan Mueller, Bjoern Bosse, Michael Hopp
INTRODUCTION: Infection is a major threat to wound healing and a leading cause of graft loss in patients undergoing meshed skin grafts (MSGs). Therefore, topical antisepsis is important in the overall treatment scheme. METHODS: An exploratory satellite group of 14 patients with infected MSGs were enrolled as part of a prospective, randomized, controlled, parallel-group, open-label, pilot Phase II study that investigated the efficacy and tolerability of 3% liposomal povidone-iodine hydrogel (PVP-ILH, Repithel(®); RepiGel(®)) versus chlorhexidine gauze in non-infected MSGs...
October 10, 2017: Infectious Diseases and Therapy
https://www.readbyqxmd.com/read/28963158/antisepsis-of-the-skin-before-spinal-surgery-with-povidone-iodine-alcohol-followed-by-chlorhexidine-gluconate-alcohol-versus-povidone-iodine-alcohol-applied-twice-for-the-prevention-of-contamination-of-the-wound-by-bacteria-a-randomised-controlled-trial
#5
RANDOMIZED CONTROLLED TRIAL
S Patrick, A McDowell, A Lee, A Frau, U Martin, E Gardner, G McLorinan, N Eames
AIMS: The aim of this study was to determine whether the sequential application of povidone iodine-alcohol (PVI) followed by chlorhexidine gluconate-alcohol (CHG) would reduce surgical wound contamination to a greater extent than PVI applied twice in patients undergoing spinal surgery. PATIENTS AND METHODS: A single-centre, interventional, two arm, parallel group randomised controlled trial was undertaken, involving 407 patients who underwent elective spinal surgery...
October 2017: Bone & Joint Journal
https://www.readbyqxmd.com/read/28796148/pain-and-antisepsis-after-ocular-administration-of-povidone-iodine-versus-chlorhexidine
#6
Carmen Oakley, Penny Allen, Joobin Hooshmand, Brendan J T Vote
PURPOSE: To investigate ocular bacterial count before and after antisepsis with aqueous chlorhexidine (AC) or povidone-iodine (PI) and to assess discomfort with each agent. METHODS: Bacterial swabs were taken from participants' eyes before and after antisepsis. These underwent microscopy, culture, and sensitivity testing. Aqueous chlorhexidine drops were administered to left eyes and PI to right eyes. Participants rated their pain (scale 0-10) for each eye but were blinded to the type of drop...
August 8, 2017: Retina
https://www.readbyqxmd.com/read/28700086/antiseptics-for-burns
#7
REVIEW
Gill Norman, Janice Christie, Zhenmi Liu, Maggie J Westby, Jayne M Jefferies, Thomas Hudson, Jacky Edwards, Devi Prasad Mohapatra, Ibrahim A Hassan, Jo C Dumville
BACKGROUND: Burn wounds cause high levels of morbidity and mortality worldwide. People with burns are particularly vulnerable to infections; over 75% of all burn deaths (after initial resuscitation) result from infection. Antiseptics are topical agents that act to prevent growth of micro-organisms. A wide range are used with the intention of preventing infection and promoting healing of burn wounds. OBJECTIVES: To assess the effects and safety of antiseptics for the treatment of burns in any care setting...
July 12, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28599898/a-randomized-open-label-controlled-trial-of-chlorhexidine-alcohol-vs-povidone-iodine-for-cesarean%C3%A2-antisepsis-the-capica-trial
#8
Edward H Springel, Xiao-Yu Wang, Vanessa M Sarfoh, Bradley P Stetzer, Steven A Weight, Brian M Mercer
BACKGROUND: Identification of optimal surgical site antisepsis preparations may reduce cesarean-related surgical site infections. Two recently published investigations examined efficacy of chlorhexidine-alcohol and iodine-alcohol preparations. No previous randomized controlled trial has compared chlorhexidine-alcohol to povidone-iodine aqueous scrub and paint in reduction of cesarean-related surgical site infection. OBJECTIVE: The purpose of the study was to determine if chlorhexidine-alcohol would result in fewer surgical site infections than povidone-iodine when used as skin antisepsis preparation prior to cesarean delivery...
October 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28583892/preoperative-chlorhexidine-versus-povidone-iodine-antisepsis-for-preventing-surgical-site-infection-a-meta-analysis-and-trial-sequential-analysis-of-randomized-controlled-trials
#9
REVIEW
Dan Zhang, Xi-Chen Wang, Zeng-Xi Yang, Jian-Xin Gan, Jie-Bin Pan, Lan-Ning Yin
BACKGROUNDS: Updated guidelines for surgical site infections (SSIs) suggested that chlorhexidine (CH) or povidone-iodine (PVI) product was equally appropriate to be applied in preoperative disinfection, but which one was optimal remained ambiguous. Moreover, recent studies reported inconsistent results. Thus, an updated meta-analysis was conducted to clarify the superiority of CH or PVI for prevention of SSIs in clean and clean-contaminated surgery. METHODS: From the inception to November 2016, Pubmed, Embase, and the Cochrane library were systematically searched for randomized controlled trials (RCTs) which explored preoperative antisepsis schemes (CH or PVI) for prevention of SSIs in clean and clean-contaminated surgery...
August 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28557536/preoperative-hand-decontamination-in-ophthalmic-surgery-a-comparison-of-the-removal-of-bacteria-from-surgeons-hands-by-routine-antimicrobial-scrub-versus-an-alcoholic-hand-rub
#10
Yaara Forer, Colin Block, Shahar Frenkel
PURPOSE: The goal of this experiment was to evaluate and compare the antimicrobial efficacy of routine preoperative hand washing using commercial medicated sponge brushes versus an alcoholic hand rub, by comparing bacterial growth on ophthalmic surgeons' hands after application of each of these methods. METHODS: Twenty ophthalmic surgeons were recruited at the Hadassah-Hebrew University Medical Center in Jerusalem, Israel. Samples were collected twice from the hands of each surgeon after hand decontamination using two different protocols during routine surgical practice...
September 2017: Current Eye Research
https://www.readbyqxmd.com/read/27778318/oral-hygiene-care-for-critically-ill-patients-to-prevent-ventilator-associated-pneumonia
#11
REVIEW
Fang Hua, Huixu Xie, Helen V Worthington, Susan Furness, Qi Zhang, Chunjie Li
BACKGROUND: Ventilator-associated pneumonia (VAP) is defined as pneumonia developing in people who have received mechanical ventilation for at least 48 hours. VAP is a potentially serious complication in these patients who are already critically ill. Oral hygiene care (OHC), using either a mouthrinse, gel, toothbrush, or combination, together with aspiration of secretions, may reduce the risk of VAP in these patients. OBJECTIVES: To assess the effects of oral hygiene care on incidence of ventilator-associated pneumonia in critically ill patients receiving mechanical ventilation in hospital intensive care units (ICUs)...
October 25, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27410189/skin-antisepsis-for-reducing-central-venous-catheter-related-infections
#12
REVIEW
Nai Ming Lai, Nai An Lai, Elizabeth O'Riordan, Nathorn Chaiyakunapruk, Jacqueline E Taylor, Kenneth Tan
BACKGROUND: The central venous catheter (CVC) is a device used for many functions, including monitoring haemodynamic indicators and administering intravenous medications, fluids, blood products and parenteral nutrition. However, as a foreign object, it is susceptible to colonisation by micro-organisms, which may lead to catheter-related blood stream infection (BSI) and in turn, increased mortality, morbidities and health care costs. OBJECTIVES: To assess the effects of skin antisepsis as part of CVC care for reducing catheter-related BSIs, catheter colonisation, and patient mortality and morbidities...
July 13, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27129749/the-effects-of-surgical-hand-scrubbing-protocols-on-skin-integrity-and-surgical-site-infection-rates-a-systematic-review
#13
REVIEW
Liang Qin Liu, Sinead Mehigan
This systematic review aimed to critically appraise and synthesize updated evidence regarding the effect of surgical-scrub techniques on skin integrity and the incidence of surgical site infections. Databases searched include the Cumulative Index to Nursing and Allied Health Literature, MEDLINE, Embase, and Cochrane Central. Our review was limited to eight peer-reviewed, randomized controlled trials and two nonrandomized controlled trials published in English from 1990 to 2015. Comparison models included traditional hand scrubbing with chlorhexidine gluconate or povidone-iodine against alcohol-based hand rubbing, scrubbing with a brush versus without a brush, and detergent-based antiseptics alone versus antiseptics incorporating alcohol solutions...
May 2016: AORN Journal
https://www.readbyqxmd.com/read/27038101/antimicrobial-efficiency-of-mouthrinses-versus-and-in-combination-with-different-photodynamic-therapies-on-periodontal-pathogens-in-an-experimental-study
#14
E-M Decker, V Bartha, A Kopunic, C von Ohle
BACKGROUND AND OBJECTIVE: In the therapy of destructive periodontal disease, chemical antimicrobial agents and increasingly photodynamic therapy (PDT) play an important adjunctive role to standard mechanical anti-infective treatment procedures. However, both antiseptic methods have their shortcomings in terms of eliminating periodontal pathogens. The aim of the study was to compare the antibacterial efficacy of different antiseptic mouthrinses, of a conventional and a new, modified PDT(plus) as well as of the different antiseptic mouthrinses combined with either the conventional or the modified PDT(plus) against periopathogens...
April 1, 2016: Journal of Periodontal Research
https://www.readbyqxmd.com/read/27007217/antimicrobial-dressings-for-the-prevention-of-catheter-related-infections-in-newborn-infants-with-central-venous-catheters
#15
REVIEW
Nai Ming Lai, Jacqueline E Taylor, Kenneth Tan, Yao Mun Choo, Azanna Ahmad Kamar, Nor Asiah Muhamad
BACKGROUND: Central venous catheters (CVCs) provide secured venous access in neonates. Antimicrobial dressings applied over the CVC sites have been proposed to reduce catheter-related blood stream infection (CRBSI) by decreasing colonisation. However, there may be concerns on the local and systemic adverse effects of these dressings in neonates. OBJECTIVES: We assessed the effectiveness and safety of antimicrobial (antiseptic or antibiotic) dressings in reducing CVC-related infections in newborn infants...
March 23, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/26799160/surgical-hand-antisepsis-to-reduce-surgical-site-infection
#16
REVIEW
Judith Tanner, Jo C Dumville, Gill Norman, Mathew Fortnam
BACKGROUND: Medical professionals routinely carry out surgical hand antisepsis before undertaking invasive procedures to destroy transient micro-organisms and inhibit the growth of resident micro-organisms. Antisepsis may reduce the risk of surgical site infections (SSIs) in patients. OBJECTIVES: To assess the effects of surgical hand antisepsis on preventing surgical site infections (SSIs) in patients treated in any setting. The secondary objective is to determine the effects of surgical hand antisepsis on the numbers of colony-forming units (CFUs) of bacteria on the hands of the surgical team...
January 22, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/26660045/evaluation-of-catheter-infection-rates-in-converted-dialysis-catheters-versus-de-novo-placement-in-the-setting-of-chlorhexidine-use
#17
COMPARATIVE STUDY
Jared M Criddle, Robert A Hieb, Sarah B White, Parag J Patel, Eric J Hohenwalter, Sean M Tutton, William S Rilling
PURPOSE: Prior studies have reported infection rates of converting non-tunneled dialysis catheters (NTDCs) to tunneled dialysis catheters (TDCs) versus de novo placement of TDCs using povidone-iodine. Chlorhexidine, per the Center of Disease Control guidelines, has been exclusively used in our institution since 2005. Therefore, our study aims to determine whether there is a difference in infection rates between conversion and de novo placement when utilizing chlorhexidine. MATERIALS AND METHODS: A retrospective analysis from 1/1/2009 to 8/10/2012 was performed of patients who underwent placement of NTDCs, which were subsequently converted to TDCs and those who underwent de novo TDC placement...
March 2016: Journal of Vascular Access
https://www.readbyqxmd.com/read/26388532/skin-antisepsis-with-chlorhexidine-alcohol-versus-povidone-iodine-alcohol-with-and-without-skin-scrubbing-for-prevention-of-intravascular-catheter-related-infection-clean-an-open-label-multicentre-randomised-controlled-two-by-two-factorial-trial
#18
RANDOMIZED CONTROLLED TRIAL
Olivier Mimoz, Jean-Christophe Lucet, Thomas Kerforne, Julien Pascal, Bertrand Souweine, Véronique Goudet, Alain Mercat, Lila Bouadma, Sigismond Lasocki, Serge Alfandari, Arnaud Friggeri, Florent Wallet, Nicolas Allou, Stéphane Ruckly, Dorothée Balayn, Alain Lepape, Jean-François Timsit
BACKGROUND: Intravascular-catheter-related infections are frequent life-threatening events in health care, but incidence can be decreased by improvements in the quality of care. Optimisation of skin antisepsis is essential to prevent short-term catheter-related infections. We hypothesised that chlorhexidine-alcohol would be more effective than povidone iodine-alcohol as a skin antiseptic to prevent intravascular-catheter-related infections. METHODS: In this open-label, randomised controlled trial with a two-by-two factorial design, we enrolled consecutive adults (age ≥18 years) admitted to one of 11 French intensive-care units and requiring at least one of central-venous, haemodialysis, or arterial catheters...
November 21, 2015: Lancet
https://www.readbyqxmd.com/read/26258558/the-combined-impact-of-surgical-team-education-and-chlorhexidine-2-alcohol-on-the-reduction-of-surgical-site-infection-following-cardiac-surgery
#19
Margaret M Hannan, Katie E O'Sullivan, Ann M Higgins, Ann-Marie Murphy, James McCarthy, Edmund Ryan, John P Hurley
BACKGROUND: The use of 2% chlorhexidine in 70% alcohol (CHG) has been associated with reduction in catheter-related bloodstream infections and surgical site infection (SSI) in general surgery. Also, improved awareness of best practice from the perspective of the operative team is likely to result in reductions in SSI rates. METHODS: This is an ambispective cohort study of patients undergoing elective cardiac surgery. Between January 2010 and December 2010, patients underwent surgical preparation using Alcohol Povidone Iodine (API)...
December 2015: Surgical Infections
https://www.readbyqxmd.com/read/25381486/comparison-of-the-efficacy-of-chlorhexidine-gluconate-versus-povidone-iodine-as-preoperative-skin-preparation-for-the-prevention-of-surgical-site-infections-in-clean-contaminated-upper-abdominal-surgeries
#20
RANDOMIZED CONTROLLED TRIAL
Anirudh Srinivas, Lileswar Kaman, Prithivi Raj, Vikas Gautam, Divya Dahiya, Gurpreet Singh, Rajinder Singh, Bikash Medhi
PURPOSE: To compare the efficacy of chlorhexidine-gluconate versus povidone iodine in preoperative skin preparation in the prevention of surgical site infections (SSIs) in clean-contaminated upper abdominal surgeries. METHODS: This was a prospective randomized controlled trial conducted on patients undergoing clean-contaminated upper abdominal surgeries. A total of 351 patients 18-70 years old were randomized into two groups; chlorhexidine and povidone iodine skin preparation before surgery...
November 2015: Surgery Today
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