Rashmi Deshmukh, Zun Zheng Ong, Radhika Rampat, Jorge L Alió Del Barrio, Ankur Barua, Marcus Ang, Jodhbir S Mehta, Dalia G Said, Harminder S Dua, Renato Ambrósio, Darren Shu Jeng Ting
Keratoconus is the most common corneal ectatic disorder. It is characterized by progressive corneal thinning with resultant irregular astigmatism and myopia. Its prevalence has been estimated at 1:375 to 1:2,000 people globally, with a considerably higher rate in the younger populations. Over the past two decades, there was a paradigm shift in the management of keratoconus. The treatment has expanded significantly from conservative management (e.g., spectacles and contact lenses wear) and penetrating keratoplasty to many other therapeutic and refractive modalities, including corneal cross-linking (with various protocols/techniques), combined CXL-keratorefractive surgeries, intracorneal ring segments, anterior lamellar keratoplasty, and more recently, Bowman's layer transplantation, stromal keratophakia, and stromal regeneration...
2023: Frontiers in Medicine