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Mooren ulcer

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https://www.readbyqxmd.com/read/29212473/case-report-bilateral-mooren-ulcer-in-association-with-hepatitis-c
#1
Vesa Aaltonen, Mari Alavesa, Laura Pirilä, Eija Vesti, Mohammad Al-Juhaish
BACKGROUND: Mooren ulcer has been considered as an idiopathic autoimmune keratitis. However, it has been in some cases suggested to be associated with hepatitis C, although the evidence is very vague. CASE PRESENTATION: We present a case of a man who was diagnosed with a primary Mooren ulcer in his right eye. The eye became blind despite of intensive treatment with local medications and extensive surgical procedures. After 10 years, the patient was diagnosed with the same disease, now in his left, previously healthy eye...
December 6, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/29210839/cataract-surgery-in-ocular-surface-diseases-clinical-challenges-and-outcomes
#2
Virender S Sangwan, Swati Gupta, Shilpa Das
PURPOSE OF REVIEW: Cataracts are a significant cause of blindness and visual impairment worldwide. With the recent advances in cataract surgery techniques, outcomes have improved significantly in uncomplicated cases. This article discusses the challenges and outcomes of cataract surgery in complex cases targeting eyes with ocular surface diseases like Stevens-Johnson syndrome, ocular cicatricial pemphigoid, Mooren's ulcer, vernal keratoconjunctivitis and limbal stem cell deficiency. RECENT FINDINGS: Ocular surface diseases are commonly associated with corneal scarring and vascularization, conjunctival inflammation, symblepharon and forniceal shortening...
January 2018: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/28985822/mooren-s-ulcerative-keratitis-after-systemic-pegylated-interferon-alpha2a-in-chronic-hepatitis-c
#3
Joon Hyung Yeo, Kyoung Woo Kim, Jae Chan Kim
No abstract text is available yet for this article.
October 2017: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/28936057/unusual-case-of-acute-corneal-hydrops-in-mooren-s-ulcer-treated-with-intracameral-injection-of-perfluoropropane
#4
Manisha Acharya, Abhishek Dave, Umang Mathur
A 15-year-old boy was diagnosed with Mooren's ulcer in the right eye at our cornea clinic. On treatment, he developed acute corneal hydrops, and the vision in the right eye dropped to perception of light. The patient was treated with intracameral injection of perfluoropropane (C3F8) gas which resulted in complete resolution of corneal edema. Contact lens fitting yielded a good visual outcome with a best-corrected visual acuity of 20/80. To the best of our knowledge, this is the only case reporting the occurrence of acute corneal hydrops in a child with Mooren's ulcer...
April 2017: Middle East African Journal of Ophthalmology
https://www.readbyqxmd.com/read/28917404/clinical-course-and-outcomes-in-patients-with-mooren-ulcer-who-had-cataract-surgery
#5
Shilpa Das, Ashik Mohamed, Virender S Sangwan
PURPOSE: To report outcomes of cataract surgery in patients with Mooren ulcer. SETTING: L.V. Prasad Eye Institute, Hyderabad, India. DESIGN: Retrospective case series. METHODS: The medical records of patients with Mooren ulcer who had cataract surgery between 2000 and 2015 were assessed. The main outcome measures were the role of preoperative immunosuppression and disease inactivity, cataract surgery safety, visual outcomes, and postoperative ulcer recurrence...
August 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28740737/clinical-characteristics-and-risk-factors-of-recurrent-mooren-s-ulcer
#6
Lixia Yang, Juan Xiao, Jiawei Wang, Han Zhang
PURPOSE: To investigate the clinical characteristics of Mooren's ulcer in East China and to identify the potential risk factors that affect the recurrence of Mooren's ulcer. METHODS: We reviewed the medical records of 95 patients (100 eyes) diagnosed with Mooren's ulcer from May 2005 to December 2014. The patients were classified into recurrent and nonrecurrent groups and followed up for 18 months. The difference between two groups was estimated. The patients in the recurrent group were subdivided according to the history of corneal infection and corneal perforation, respectively...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28716777/customised-crescentic-corneal-transplant-with-conjunctival-resection-in-an-atypical-case-of-malignant-mooren-s-ulcer
#7
Jayanand Urkude, Rashmi Singh, Manthan Chaniyara, Amar Pujari
No abstract text is available yet for this article.
July 17, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28619029/rapid-deterioration-of-mooren-s-ulcers-after-conjunctival-flap-a-review-of-2-cases
#8
REVIEW
Saiqun Li, Yuqing Deng, Caiyuan Du, Haixiang Huang, Jing Zhong, Ling Chen, Bowen Wang, Jin Yuan
BACKGROUND: Conjunctival flaps are a widely used treatment for numerous corneal ulcers that are caused by microorganismal infections. However, whether it can be performed on immune-mediated corneal ulcers is controversial. CASE PRESENTATION: We present two cases of Mooren's ulcer that were treated using conjunctival flap in an attempt to prevent further corneal perforation at their local hospital. A rapid acceleration in ulcer progression was observed after a conjunctival flap was applied...
June 15, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28286571/we-are-not-alone-a-case-for-the-human-microbiome-in-extra-intestinal-diseases
#9
EDITORIAL
S Shivaji
BACKGROUND: "Dysbiosis" in the gut microbiome has been implicated in auto-immune diseases, in inflammatory diseases, in some cancers and mental disorders. The challenge is to unravel the cellular and molecular basis of dysbiosis so as to understand the disease manifestation. MAIN BODY: Next generation sequencing and genome enabled technologies have led to the establishment of the composition of gut microbiomes and established that "dysbiosis" is the cause of several diseases...
2017: Gut Pathogens
https://www.readbyqxmd.com/read/28060068/risk-factors-clinical-features-and-treatment-outcomes-of-recurrent-mooren-ulcers-in-china
#10
Yanling Dong, Yangyang Zhang, Lixin Xie, Jianmei Ren
PURPOSE: To investigate risk factors, clinical features, and treatment outcomes of recurrent Mooren ulcers in China. METHODS: Medical records of 139 patients (173 eyes) with Mooren ulcers, including 37 patients (38 eyes) with recurrence, were retrospectively reviewed. Clinical features and treatment outcomes were evaluated. The risk factors for ulcer recurrence were analyzed with logistic regression; the cumulative risk of recurrence was assessed with Kaplan-Meier analysis...
February 2017: Cornea
https://www.readbyqxmd.com/read/27861303/risk-factors-clinical-features-and-treatment-outcomes-of-recurrent-mooren-ulcers-in-china
#11
Yanling Dong, Yangyang Zhang, Lixin Xie, Jianmei Ren
PURPOSE: To investigate risk factors, clinical features, and treatment outcomes of recurrent Mooren ulcers in China. METHODS: Medical records of 139 patients (173 eyes) with Mooren ulcers, including 37 patients (38 eyes) with recurrence, were retrospectively reviewed. Clinical features and treatment outcomes were evaluated. The risk factors for ulcer recurrence were analyzed with logistic regression; the cumulative risk of recurrence was assessed with Kaplan-Meier analysis...
November 16, 2016: Cornea
https://www.readbyqxmd.com/read/27796668/upregulation-of-nlrp3-inflammasome-components-in-mooren-s-ulcer
#12
Zhiyuan Li, Chao Wei, Shuang Wang, Ting Liu, Hualei Zhai, Weiyun Shi
PURPOSE: Mooren's ulcer (MU) is a peripheral corneal ulceration of presumed autoimmune etiology. NLRP3 inflammasome has been shown to be involved in a variety of autoimmune and auto-inflammatory diseases. However, the role of NLRP3 inflammasome in MU has not been investigated. Here, we evaluate the expression of NLRP3 inflammasome and its downstream inflammatory factors in human MU. METHODS: Conjunctival biopsy specimens were obtained from seven patients with MU and six healthy donors...
March 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/27755290/mooren-ulcer-in-a-child-wearing-orthokeratology-contact-lenses
#13
Jaeyoung Kim, Mee Kum Kim, Won Ryang Wee, Joo Youn Oh
PURPOSE: To report a case of Mooren ulcer that developed in a pediatric patient wearing orthokeratology overnight contact lenses. METHODS: Case report. RESULTS: A 10-year-old boy was referred to our clinic because of progressive peripheral corneal ulcer in the right eye, despite the intensive use of fortified antibiotic eye drops. The patient had been using overnight orthokeratology lenses for 4 months before presentation of corneal ulcer...
October 13, 2016: Eye & Contact Lens
https://www.readbyqxmd.com/read/27450147/management-of-severe-and-refractory-mooren-s-ulcers-with-rituximab
#14
Damien Guindolet, Clotilde Reynaud, Gaelle Clavel, Georges Belangé, Maycene Benmahmed, Serge Doan, Gilles Hayem, Isabelle Cochereau, Eric E Gabison
PURPOSE: Management of severe and refractory Mooren's ulcers is challenging as it encompasses tectonic surgical treatment and aggressive immunosuppressive therapies. Efficacy of rituximab in the management of severe Mooren's ulcers has never been reported. METHODS: Five patients (six eyes) from the Cornea and External Disorders department at the Rothschild Ophthalmologic Foundation (Paris, France) were treated for severe Mooren's ulcer unresponsive to conventional treatments between 2008 and 2016...
April 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/27347060/keratopathy-due-to-ophthalmic-drug-abuse-with-corneal-melting-and-perforation-presenting-as-mooren-like-ulcer-a-case-report
#15
Hui Wu, Yuan Hu, Xiao-Ru Shi, Feihong Xu, Chun-Ying Jiang, Rong Huang, Hui Jia
The present report describes the clinical course and treatment of a Mooren-like ulcer associated with abuse of topical anesthetics and dexamethasone. A 38-year-old male physician treated himself with lidocaine, tetracaine and dexamethasone (DEX) eye drops for severe pain and decline of vision in both eyes. After six months of treatment, his right cornea exhibited annular melting with full-thickness stromal infiltration at the limbus and central corneal haze. His left cornea was completely melted and exhibited iris prolapse...
July 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/26897333/mooren-s-ulcer-30-years-of-follow-up
#16
F Vilaplana, J Temprano, J L Riquelme, J Nadal, J Barraquer
CASE REPORT: A 33-year-old Caucasian female presented with epiphora, ocular pain, and foreign body sensation in both eyes for one month. Examination revealed bilateral peripheral corneal ulcers. The patient had been treated with immunomodulators, and she was treated in the left eye with peripheral semi-circular keratoplasty, penetrating keratoplasty, conjunctival-corneal-scleroplasty, buccal mucosal graft, tibial osteo-keratoprosthesis and finally, retinal detachment. DISCUSSION: Mooren's ulcer is an immunological corneal disease...
July 2016: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/26553919/efficacy-of-conjunctival-resection-with-cyanoacrylate-glue-application-in-preventing-recurrences-of-mooren-s-ulcer
#17
Ikeda Lal, Srinivas B Shivanagari, Mohammed Hasnat Ali, Jayesh Vazirani
AIM: To evaluate the role of conjunctival resection along with cyanoacrylate glue and bandage contact lens application in preventing recurrences and arresting progression in cases of Mooren's ulcer. METHOD: This retrospective interventional case series included cases of Mooren's ulcer that underwent conjunctival resection with cyanoacrylate glue and bandage contact lens application between 2011 and 2014. Systemic immunosuppression was initiated depending on the laterality and severity of disease...
July 2016: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/26180482/amniotic-membrane-transplant-with-a-special-technique-motowa-s-sandwich-technique-in-mooren-s-ulcer
#18
Saeed Al Motowa, Mohammed Al Zobidi
To illustrate amniotic membrane transplant (AMT) with a novel surgical technique ("sandwich technique") for treating patients with malignant Mooren's ulcer. A case report of a patient with bilateral, malignant Mooren's ulcer who had undergone systemic steroid therapy and topical immunosuppresive therapy to stabilize his condition. However, perforation of cornea occurred in one eye. AMT with a new surgical technique ("Motowa's sandwich technique") was performed to treat this case. On the 1(st) day postoperatively, there was no pain, no photophobia, and visual acuity was same as preoperatively...
July 2015: Middle East African Journal of Ophthalmology
https://www.readbyqxmd.com/read/26155087/bilateral-mooren-s-ulcer-customised-corneal-graft-with-additional-amniotic-membrane-graft
#19
Vipul Bhandari, K S Siddharthan
Mooren's ulcer (MU) is a rare and painful peripheral corneal ulceration which occurs in the absence of any associated scleritis, and any detectable systemic disease. A 60-year-old male patient was referred to us with bilateral peripheral corneal ulceration. Best corrected visual acuity (BCVA) in both eyes was counting finger at one metre. The right eye showed a 180° thinning with perforation at 8 o'clock position. The left eye showed a 360° thinning with central contact lens type cornea. After complete blood analysis we started the patient on cyclophosphamide orally along with high doses of oral steroids...
July 2015: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
https://www.readbyqxmd.com/read/25970436/interplay-of-immune-cells-in-mooren-ulcer
#20
Hyun Ju Lee, Mee Kum Kim, Won Ryang Wee, Joo Youn Oh
PURPOSE: To report the histopathological findings of the cornea with fulminant Mooren ulcer, an idiopathic autoimmune keratitis. METHODS: A 54-year-old woman was diagnosed with Mooren ulcer. Despite intensive immunosuppression, corneal perforation developed, and penetrating keratoplasty with a limbal tectonic graft was performed. The removed cornea was histopathologically evaluated for the phenotype of the cells infiltrating the lesion. RESULTS: Hematoxylin-eosin staining showed massive infiltration of inflammatory cells in the anterior corneal stroma and epithelial hyperplasia in the adjacent conjunctiva...
September 2015: Cornea
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