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Mooren ulcer

Yanling Dong, Yangyang Zhang, Lixin Xie, Jianmei Ren
PURPOSE: To investigate risk factors, clinical features, and treatment outcomes of recurrent Mooren ulcers in China. METHODS: Medical records of 139 patients (173 eyes) with Mooren ulcers, including 37 patients (38 eyes) with recurrence, were retrospectively reviewed. Clinical features and treatment outcomes were evaluated. The risk factors for ulcer recurrence were analyzed with logistic regression; the cumulative risk of recurrence was assessed with Kaplan-Meier analysis...
February 2017: Cornea
Yanling Dong, Yangyang Zhang, Lixin Xie, Jianmei Ren
PURPOSE: To investigate risk factors, clinical features, and treatment outcomes of recurrent Mooren ulcers in China. METHODS: Medical records of 139 patients (173 eyes) with Mooren ulcers, including 37 patients (38 eyes) with recurrence, were retrospectively reviewed. Clinical features and treatment outcomes were evaluated. The risk factors for ulcer recurrence were analyzed with logistic regression; the cumulative risk of recurrence was assessed with Kaplan-Meier analysis...
November 16, 2016: Cornea
Zhiyuan Li, Chao Wei, Shuang Wang, Ting Liu, Hualei Zhai, Weiyun Shi
PURPOSE: Mooren's ulcer (MU) is a peripheral corneal ulceration of presumed autoimmune etiology. NLRP3 inflammasome has been shown to be involved in a variety of autoimmune and auto-inflammatory diseases. However, the role of NLRP3 inflammasome in MU has not been investigated. Here, we evaluate the expression of NLRP3 inflammasome and its downstream inflammatory factors in human MU. METHODS: Conjunctival biopsy specimens were obtained from seven patients with MU and six healthy donors...
October 28, 2016: Graefe's Archive for Clinical and Experimental Ophthalmology
Jaeyoung Kim, Mee Kum Kim, Won Ryang Wee, Joo Youn Oh
PURPOSE: To report a case of Mooren ulcer that developed in a pediatric patient wearing orthokeratology overnight contact lenses. METHODS: Case report. RESULTS: A 10-year-old boy was referred to our clinic because of progressive peripheral corneal ulcer in the right eye, despite the intensive use of fortified antibiotic eye drops. The patient had been using overnight orthokeratology lenses for 4 months before presentation of corneal ulcer...
October 13, 2016: Eye & Contact Lens
Damien Guindolet, Clotilde Reynaud, Gaelle Clavel, Georges Belangé, Maycene Benmahmed, Serge Doan, Gilles Hayem, Isabelle Cochereau, Eric E Gabison
PURPOSE: Management of severe and refractory Mooren's ulcers is challenging as it encompasses tectonic surgical treatment and aggressive immunosuppressive therapies. Efficacy of rituximab in the management of severe Mooren's ulcers has never been reported. METHODS: Five patients (six eyes) from the Cornea and External Disorders department at the Rothschild Ophthalmologic Foundation (Paris, France) were treated for severe Mooren's ulcer unresponsive to conventional treatments between 2008 and 2016...
July 22, 2016: British Journal of Ophthalmology
Hui Wu, Yuan Hu, Xiao-Ru Shi, Feihong Xu, Chun-Ying Jiang, Rong Huang, Hui Jia
The present report describes the clinical course and treatment of a Mooren-like ulcer associated with abuse of topical anesthetics and dexamethasone. A 38-year-old male physician treated himself with lidocaine, tetracaine and dexamethasone (DEX) eye drops for severe pain and decline of vision in both eyes. After six months of treatment, his right cornea exhibited annular melting with full-thickness stromal infiltration at the limbus and central corneal haze. His left cornea was completely melted and exhibited iris prolapse...
July 2016: Experimental and Therapeutic Medicine
F Vilaplana, J Temprano, J L Riquelme, J Nadal, J Barraquer
CASE REPORT: A 33-year-old Caucasian female presented with epiphora, ocular pain, and foreign body sensation in both eyes for one month. Examination revealed bilateral peripheral corneal ulcers. The patient had been treated with immunomodulators, and she was treated in the left eye with peripheral semi-circular keratoplasty, penetrating keratoplasty, conjunctival-corneal-scleroplasty, buccal mucosal graft, tibial osteo-keratoprosthesis and finally, retinal detachment. DISCUSSION: Mooren's ulcer is an immunological corneal disease...
July 2016: Archivos de la Sociedad Española de Oftalmología
Ikeda Lal, Srinivas B Shivanagari, Mohammed Hasnat Ali, Jayesh Vazirani
AIM: To evaluate the role of conjunctival resection along with cyanoacrylate glue and bandage contact lens application in preventing recurrences and arresting progression in cases of Mooren's ulcer. METHOD: This retrospective interventional case series included cases of Mooren's ulcer that underwent conjunctival resection with cyanoacrylate glue and bandage contact lens application between 2011 and 2014. Systemic immunosuppression was initiated depending on the laterality and severity of disease...
November 9, 2015: British Journal of Ophthalmology
Saeed Al Motowa, Mohammed Al Zobidi
To illustrate amniotic membrane transplant (AMT) with a novel surgical technique ("sandwich technique") for treating patients with malignant Mooren's ulcer. A case report of a patient with bilateral, malignant Mooren's ulcer who had undergone systemic steroid therapy and topical immunosuppresive therapy to stabilize his condition. However, perforation of cornea occurred in one eye. AMT with a new surgical technique ("Motowa's sandwich technique") was performed to treat this case. On the 1(st) day postoperatively, there was no pain, no photophobia, and visual acuity was same as preoperatively...
July 2015: Middle East African Journal of Ophthalmology
Vipul Bhandari, K S Siddharthan
Mooren's ulcer (MU) is a rare and painful peripheral corneal ulceration which occurs in the absence of any associated scleritis, and any detectable systemic disease. A 60-year-old male patient was referred to us with bilateral peripheral corneal ulceration. Best corrected visual acuity (BCVA) in both eyes was counting finger at one metre. The right eye showed a 180° thinning with perforation at 8 o'clock position. The left eye showed a 360° thinning with central contact lens type cornea. After complete blood analysis we started the patient on cyclophosphamide orally along with high doses of oral steroids...
July 2015: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
Hyun Ju Lee, Mee Kum Kim, Won Ryang Wee, Joo Youn Oh
PURPOSE: To report the histopathological findings of the cornea with fulminant Mooren ulcer, an idiopathic autoimmune keratitis. METHODS: A 54-year-old woman was diagnosed with Mooren ulcer. Despite intensive immunosuppression, corneal perforation developed, and penetrating keratoplasty with a limbal tectonic graft was performed. The removed cornea was histopathologically evaluated for the phenotype of the cells infiltrating the lesion. RESULTS: Hematoxylin-eosin staining showed massive infiltration of inflammatory cells in the anterior corneal stroma and epithelial hyperplasia in the adjacent conjunctiva...
September 2015: Cornea
Namrata Sharma, Gautam Sinha, Himanshu Shekhar, Jeewan S Titiyal, Tushar Agarwal, Bhavna Chawla, Radhika Tandon, Rasik B Vajpayee
PURPOSE: To evaluate aetiology, demographic profile, clinical features and outcomes in cases of peripheral ulcerative keratitis (PUK). METHODS: Seventy-six eyes of 65 consecutive patients with PUK were evaluated in this prospective interventional study over an 18 month period, which were followed for 3 years. The main outcome measures were sociodemographic profile, aetiology, clinical features, management strategies and outcome. RESULTS: Sixty per cent (39/65) of cases were men and mean age was 45...
November 2015: British Journal of Ophthalmology
Sung Wook Wee, Sang Uk Choi, Jae Chan Kim
PURPOSE: To report the clinical outcomes of deep anterior lamellar keratoplasty (DALK) when sterile gamma-irradiated acellular corneal tissues (VisionGraft) are used in combination with amniotic membrane transplantation (AMT) for intractable ocular surface diseases. METHODS: The medical records of fifteen patients who had DALK with AMT were retrospectively reviewed. Indications for surgery included ocular burn, bacterial keratitis, herpes simplex virus keratitis, corneal opacity with Stevens-Johnson syndrome, Mooren's ulcer, idiopathic myxoid degeneration of corneal stroma, and recurrent band keratopathy...
April 2015: Korean Journal of Ophthalmology: KJO
O Fasina, Ao Ogundipe, Ei Ezichi
BACKGROUND: Mooren's ulcer has been described as an idiopathic, painful, relentless, peripheral, chronic ulcerative keratitis that progresses circumferentially and centrally, with an unusual geographical presentation and distribution. AIM: To review the demographic and clinical characteristics of patients with Mooren's ulcer at University College Hospital, Ibadan, Nigeria over seven years, and, the outcome of treatment. STUDY DESIGN: A retrospective case series...
July 2013: Journal of the West African College of Surgeons
Juncai Liu, Weiyun Shi, Suxia Li, Hua Gao, Ting Wang
AIM: To observe the efficacy of modified lamellar keratoplasty (LK) and immunosuppressive therapy guided by in vivo confocal microscopy (IVCM) for perforated Mooren's ulcer. METHODS: 25 patients (31 eyes) with perforated Mooren's ulcer underwent modified LK. The perforated hole was patched with a thin, fresh posterior cornea containing the endothelium, before a glycerin-preserved lamellar graft shaped like the defect was placed. Immunosuppressants and corticosteroids were used and their dosages adjusted following the density of dendritic cells in the corneal graft postoperatively as detected by IVCM...
June 2015: British Journal of Ophthalmology
Masahito Yoshihara, Naoyuki Maeda, Takeshi Soma, Mutsumi Fuchihata, Asumi Hayashi, Shizuka Koh, Yoshinori Oie, Kohji Nishida
PURPOSE: To investigate the corneal topography and visual function of patients with Mooren ulcer using 3-dimensional anterior segment optical coherence tomography (3-D AS-OCT). METHODS: Fourteen eyes of 9 patients with Mooren ulcer were studied. Pachymetric and axial power maps were obtained by 3-D AS-OCT. The axial power maps were classified into 3 patterns by visual inspection. The distribution of the corneal dioptric power was analyzed by Fourier harmonic expansion...
January 2015: Cornea
Dong Hyun Kim, Mee Kum Kim, Won Ryang Wee, Joo Youn Oh
PURPOSE: To investigate the clinical characteristics of patients with Mooren's ulcer in the Korean population, and to identify the risk factors that affect the therapeutic outcome. METHODS: We reviewed the medical records of 33 eyes of 24 Korean patients who were referred to a cornea clinic and clinically diagnosed with Mooren's ulcer. RESULTS: Despite intensive immunosuppression, corneal perforation occurred in 16 of 24 (66.7%) patients, which required tectonic graft...
2016: Ocular Immunology and Inflammation
Hua Gao, Xiuxian Wang, Jose J Echegaray, Suxia Li, Ting Wang, Weiyun Shi
BACKGROUND: To evaluate the feasibility of partial lamellar keratoplasty (LK) for treatment of peripheral corneal disease (PCD) using a graft from the corneoscleral rim preserved in glycerin. METHODS: Patients who underwent LK for PCD at Shandong Eye Hospital from January 2006 to December 2012 were included. Corneoscleral rims of donor grafts, out of which the corneal buttons had been punched and used for penetrating keratoplasty, were preserved in glycerin and used for LK procedures...
June 2014: Graefe's Archive for Clinical and Experimental Ophthalmology
Xiaohua Li, Liya Wang, Laurie Dustin, Qiucai Wei
PURPOSE: To analyze the age distribution of corneal disease in China by histopathological examination. METHODS: A retrospective histopathological analysis of the prevalence and age distribution of corneal disease was performed on corneal specimens from 3112 patients who underwent corneal surgery between 2001 and 2012 in the Henan Eye Institute. RESULTS: Infectious keratitis (2212 specimens, 71.08%) was the most common corneal disease. The distribution of age groups was significantly higher after age 30 (16...
May 2014: Investigative Ophthalmology & Visual Science
Hsiao-Sang Chu, Min-Chin Hsieh, Yan-Ming Chen, Yu-Chih Hou, Fung-Rong Hu, Wei-Li Chen
PURPOSE: The aim of this study was to evaluate the feasibility of storing anterior corneal buttons split from donor Descemet stripping automated endothelial keratoplasty (DSAEK) tissue for later use in tectonic lamellar patch grafting. METHODS: Donor corneas for DSAEK were split into anterior and posterior lamellae using a 350-μm depth microkeratome, and the remaining anterior corneal buttons were stored for up to 4 weeks at 4°C in Optisol GS before use in patch grafting of the cornea and sclera...
June 2014: Cornea
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