AMT bullous keratopathy

PURPOSE: The amniotic membrane (AM), the inner layer of the placenta, is a semitransparent, avascular and thin tissue that is useful due to its structure. Amniotic membrane transplantation (AMT) avoids the need for keratoplasty to prevent corneal perforating. The purpose of the study was to evaluate the visual (gain of or no change in visual acuity) and corneal outcomes (closure of the ulcer or corneal healing) of AMT in patients with ocular surface diseases. MATERIALS AND METHODS: This was a retrospective case control study (success or failure of the surgery)...

UNLABELLED: Secondary decompensation of corneal endothelium, including transplanted, is a frequent long-term complication of glaucoma drainage surgery. According to literature data, after implantation of a glaucoma drainage device into the anterior chamber, the speed of endothelial cells density (ECD) loss increases significantly. PURPOSE: To study the possibility of performing modified Descemet membrane endothelial keratoplasty (DMEK) with maximum graft diameter, and to assess its short-term effectiveness in the treatment of bullous keratopathy (BK) in the presence of a glaucoma drainage device in the anterior chamber...

PURPOSE: To describe quantitative and qualitative features of eyes with advanced bullous keratopathy assessed using ultrasound biomicroscopy, before and after anterior stromal puncture (ASP) or amniotic membrane transplantation (AMT) procedures to relieve chronic pain. METHODS: The present descriptive comparative study included 40 eyes of 40 patients with chronic intermittent pain due to bullous keratopathy who were randomly assigned to one of the two treatments (AMT or ASP)...

OBJECTIVE: To observe form and function changes of vascular endothelial cells (VEC) which were transplanted to the posterior surface of rhesus monkey cornea without Descemet's Membrane by anterior chamber injection, explore the feasibility of transplanting VEC to treat corneal endothelial injury, and find new method of corneal endothelial cell transplantation. METHODS: Cultured VEC to proliferate in vitro.Rhesus monkeys were randomly divided into two groups: Experimental group (6) and control group (6) according to a random number table...

OBJECTIVE: To Explore the feasibility of rhesus monkey vascular endothelial cell(RMVEC) transplantation to substitute the allogeneic corneal endothelial cells(CEC), through observe the morphologic and functional change of the vascular endothelial cell which was transplanted to the inner surface of cornea without Descemet's membrane. METHODS: It was an experimental study. The rhesus monkey vascular endothelial cell was cultivated to proliferation and marked by BrdU in vitro...

PURPOSE: To compare amniotic membrane transplantation (AMT) and anterior stromal puncture (ASP) in the management of pain in patients with symptomatic bullous keratopathy (BK). METHODS: In this prospective comparative study, 40 eyes of 40 patients with symptomatic BK (chronic intermittent pain) were randomised and divided into two groups (AMT and ASP) according to the technique used to treat symptomatic BK. The patients were examined on days 1, 14, 30, 90 and 180 postoperatively...

Bullous keratopathy (BK) is a chronic corneal edema with or without subepithelial bullae as a result of a loss of the endothelial cells. 15 patients with BK after cataract surgery with intraocular lens implantation, due to Fuchs dystrophy (n = 3) or corneal endothelial trauma (n = 12) were included in the study. All patients were treated by amniotic membrane transplantation (AMT). Corneal epithelial cells in patients suffering from BK secreted 3.91 +/- 3.09 pg/mL of IL-1 alpha, 4446 +/- 16.8 pg/mL of TNF and 81...

BACKGROUND: Ocular surface disorders (OSD) are challenging to treat. They can introduce serious morbidity and might even lead to visual loss. In such situations, keratoplasty remains the last option. Amniotic membrane transplantation (AMT) has been shown to be effective in the management of ocular surface pathologies. The aim of the study was to assess the efficacy of AMT for various indications of OSD. MATERIALS AND METHODS: Experience of AMT in 65 patients with different OSD was evaluated...

A case of painful bullous keratopathy (PBK) treated using author's procedure of anterior stromal puncture (ASP) combined with amniotic membrane transplantation (AMT) is presented. ASP combined with AMT can be effective option for pain relief and promotion of epithelial healing in patients with PBK and poor visual potential.

OBJECTIVE: To report the outcomes of anterior stromal micropuncture (ASP) combined with amniotic membrane transplantation (AMT) in the management of painful bullous keratopathy (BK) with poor visual potential, and to assess amniotic membrane (AM) retention. DESIGN: Case series, retrospective review. PARTICIPANTS: Twelve eyes of 12 patients with BK causing intractable pain or discomfort and poor visual potential, treated between March 2006 and October 2008 at Gartnavel General Hospital, Glasgow...

PURPOSE: To report a case of Descemet stripping endothelial keratoplasty (DSEK) with a large posterior lamellar graft for the treatment of bullous keratopathy secondary to congenital glaucoma. METHODS: Bullous keratopathy secondary to unilateral congenital glaucoma with buphthalmos in a 36-year-old man was treated with DSEK. A Descemet endothelium lamella of 10-mm diameter was excised by descemetorhexis. A regular sclerocorneal donor button of 12-mm diameter was manually split using the Melles technique, and a 10-mm diameter donor graft was punched...

PURPOSE: To compare the efficacy and safety of phototherapeutic keratectomy (PTK) and amniotic membrane transplantation (AMT) for symptomatic relief in painful bullous keratopathy. METHODS: Twenty-five eyes of 25 patients with symptomatic bullous keratopathy and poor visual potential were randomized into 2 groups. In the PTK group (n = 13) after manual epithelial debridement, 100-microm excimer laser ablation was performed. In the AMT group (n = 12), the corneal epithelium was scraped and cryopreserved amniotic membrane with basement membrane side up was secured with 10-0 monofilament nylon sutures...

PURPOSE: To determine factors influencing graft survival and visual outcome 10 years after penetrating keratoplasty. METHODS: Ten-year follow-up data were obtained from a cohort of patients that represented 20% of corneal transplants in Sweden between 1996 and 1998. Multiple regression analyses (logistic and linear) were performed on graft survival and visual outcome (visual acuity and astigmatism). RESULTS: Of the initial 242 patients receiving a corneal transplant during 1996-1998, 140 were available at 10 years...

PURPOSE: To evaluate the learning curve and the outcome of Descemet Automated Endothelial Keratoplasty (DSAEK) in patients with primary or secondary endothelial decompensation. METHODS: DSAEK was performed in 100 eyes with endothelial decompensation (Fuchs' Dystrophy n = 59; pseudophakic bullous keratopathy n = 33; failed corneal graft n = 8). All patients underwent a standard procedure including the following steps: Descemet membrane and endothelium removal from the recipient cornea under air; inferior peripheral iridectomy; microkeratome-assisted preparation of a donor lamella consisting of deep stroma and endothelium (between 100 and 200 micron in thickness), which is punched to desired size (8...

PURPOSE: To explore the feasibility of reattaching the dislocated graft with viscoelastic in abnormally structured eyes after Descemet-stripping automated endothelial keratoplasty (DSAEK). DESIGN: Retrospective case series. PARTICIPANTS: Five pseudophakic bullous keratopathy cases (5 eyes) with a history of vitrectomy and/or iris-lens diaphragm injury. METHODS: After DSAEK, graft dislocation occurred in each of the 5 cases (5 eyes)...

PURPOSE: To evaluate the histologic changes occurring in the transplanted amniotic membrane in human eyes. DESIGN: Observational consecutive case series. PARTICIPANTS: Seven consecutive patients who underwent amniotic membrane transplantation (AMT) for bullous keratopathy and subsequently had a penetrating keratoplasty (PK). METHODS: Corneal buttons obtained at PK were examined by light and electron microscopy and by immunohistology with antibodies against CD34 (keratocytes), alpha smooth muscle actin and vimentin (myofibroblasts and fibroblasts respectively)...

PURPOSE: To determine the outcomes of a modified amniotic membrane transplantation (AMT) suturing technique for pain and discomfort relief in patients with symptomatic bullous keratopathy (BK). DESIGN: Randomized, double-blind controlled clinical trial. METHODS: setting: Ankara Research and Training Hospital 1st and 2nd Eye Clinics, Ankara, Turkey. study population: This prospective study included 39 eyes (39 patients) with BK presenting with intractable pain or discomfort and poor visual potential...

PURPOSE: To investigate the efficacy of permanent amniotic membrane transplantation (AMT) for the treatment of various ocular surface diseases. METHODS: The medical records of 62 eyes from 58 patients who had undergone permanent AMT were reviewed. The amniotic patches were grafted for the treatment of neurotrophic ulcers (n=15), inflammatory corneal ulcers (n=15), scleral ulcers (n=11), painful bullous keratopathy (n=8) and pterygium as an adjuvant to a conjunctival autograft (n=13)...

PURPOSE: To report the occurrence of hypopyon iritis after primary, fresh amniotic membrane transplant (AMT). METHODS: A case report of a 65-year-old man who underwent AMT along with placement of hydrophilic contact lens for symptomatic relief of pseudophakic bullous keratopathy for the first time. The amniotic membrane (AM) transplanted was obtained freshly after an elective cesarean section. RESULTS: The patient developed hypopyon on the second postoperative day...

PURPOSE: To report a case of fungal keratitis following amniotic membrane (AM) transplantation for pseudophakic bullous keratopathy. METHOD: A 55-year-old female underwent amniotic membrane transplantation (AMT) with epithelial debridement and anterior stromal puncture in the left eye for symptomatic bullous keratopathy. She developed fungal keratitis after 4 weeks. RESULT: Aspergillus sp. was isolated from the corneal scraping. The patient was treated with systemic and topical antifungal medication...