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AMT bullous keratopathy

Fabiana dos Santos Paris, Eliana Domingues Gonçalves, Maira Saad Ávila Morales, Liliane Andrade Almeida Kanecadan, Mauro Silveira de Queiroz Campos, José Álvaro Pereira Gomes, Norma Allemann, Elcio Hideo Sato
PURPOSE: To describe quantitative and qualitative features of eyes with advanced bullous keratopathy assessed using ultrasound biomicroscopy, before and after anterior stromal puncture (ASP) or amniotic membrane transplantation (AMT) procedures to relieve chronic pain. METHODS: The present descriptive comparative study included 40 eyes of 40 patients with chronic intermittent pain due to bullous keratopathy who were randomly assigned to one of the two treatments (AMT or ASP)...
November 2014: Arquivos Brasileiros de Oftalmologia
Qin Zhu, Zhulin Hu, Xiaomei Sun, Min Hu, Hai Liu, Zhongkun Yang
OBJECTIVE: To observe form and function changes of vascular endothelial cells (VEC) which were transplanted to the posterior surface of rhesus monkey cornea without Descemet's Membrane by anterior chamber injection, explore the feasibility of transplanting VEC to treat corneal endothelial injury, and find new method of corneal endothelial cell transplantation. METHODS: Cultured VEC to proliferate in vitro.Rhesus monkeys were randomly divided into two groups: Experimental group (6) and control group (6) according to a random number table...
April 2014: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
Qin Zhu, Min Hu, Xiao-mei Sun, Hai Liu, Zhong-kun Yang, Xie-jie Dai, Zhu-lin Hu
OBJECTIVE: To Explore the feasibility of rhesus monkey vascular endothelial cell(RMVEC) transplantation to substitute the allogeneic corneal endothelial cells(CEC), through observe the morphologic and functional change of the vascular endothelial cell which was transplanted to the inner surface of cornea without Descemet's membrane. METHODS: It was an experimental study. The rhesus monkey vascular endothelial cell was cultivated to proliferation and marked by BrdU in vitro...
November 2013: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
Fabiana dos Santos Paris, Eliana Domingues Gonçalves, Mauro Silveira de Queiroz Campos, Elcio Hideo Sato, Harminder S Dua, José Álvaro Pereira Gomes
PURPOSE: To compare amniotic membrane transplantation (AMT) and anterior stromal puncture (ASP) in the management of pain in patients with symptomatic bullous keratopathy (BK). METHODS: In this prospective comparative study, 40 eyes of 40 patients with symptomatic BK (chronic intermittent pain) were randomised and divided into two groups (AMT and ASP) according to the technique used to treat symptomatic BK. The patients were examined on days 1, 14, 30, 90 and 180 postoperatively...
August 2013: British Journal of Ophthalmology
Renata Grzetić-Lenac, Maja Merlak, Tihomir Balog, Vedran Markusić, Iva Dekaris
Bullous keratopathy (BK) is a chronic corneal edema with or without subepithelial bullae as a result of a loss of the endothelial cells. 15 patients with BK after cataract surgery with intraocular lens implantation, due to Fuchs dystrophy (n = 3) or corneal endothelial trauma (n = 12) were included in the study. All patients were treated by amniotic membrane transplantation (AMT). Corneal epithelial cells in patients suffering from BK secreted 3.91 +/- 3.09 pg/mL of IL-1 alpha, 4446 +/- 16.8 pg/mL of TNF and 81...
September 2011: Collegium Antropologicum
Shreya Thatte
BACKGROUND: Ocular surface disorders (OSD) are challenging to treat. They can introduce serious morbidity and might even lead to visual loss. In such situations, keratoplasty remains the last option. Amniotic membrane transplantation (AMT) has been shown to be effective in the management of ocular surface pathologies. The aim of the study was to assess the efficacy of AMT for various indications of OSD. MATERIALS AND METHODS: Experience of AMT in 65 patients with different OSD was evaluated...
May 2011: Oman Journal of Ophthalmology
E A Kasparova, S Wang, N V Borodina
A case of painful bullous keratopathy (PBK) treated using author's procedure of anterior stromal puncture (ASP) combined with amniotic membrane transplantation (AMT) is presented. ASP combined with AMT can be effective option for pain relief and promotion of epithelial healing in patients with PBK and poor visual potential.
May 2011: Vestnik Oftalmologii
Maria Elena Gregory, Kurt Spiteri-Cornish, Bernardine Hegarty, Sanjay Mantry, Kanna Ramaesh
OBJECTIVE: To report the outcomes of anterior stromal micropuncture (ASP) combined with amniotic membrane transplantation (AMT) in the management of painful bullous keratopathy (BK) with poor visual potential, and to assess amniotic membrane (AM) retention. DESIGN: Case series, retrospective review. PARTICIPANTS: Twelve eyes of 12 patients with BK causing intractable pain or discomfort and poor visual potential, treated between March 2006 and October 2008 at Gartnavel General Hospital, Glasgow...
April 2011: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
Jan Darius Unterlauft, Katharina Weller, Gerd Geerling
PURPOSE: To report a case of Descemet stripping endothelial keratoplasty (DSEK) with a large posterior lamellar graft for the treatment of bullous keratopathy secondary to congenital glaucoma. METHODS: Bullous keratopathy secondary to unilateral congenital glaucoma with buphthalmos in a 36-year-old man was treated with DSEK. A Descemet endothelium lamella of 10-mm diameter was excised by descemetorhexis. A regular sclerocorneal donor button of 12-mm diameter was manually split using the Melles technique, and a 10-mm diameter donor graft was punched...
October 2010: Cornea
Bhavna Chawla, Namrata Sharma, Radhika Tandon, Mani Kalaivani, Jeewan S Titiyal, Rasik B Vajpayee
PURPOSE: To compare the efficacy and safety of phototherapeutic keratectomy (PTK) and amniotic membrane transplantation (AMT) for symptomatic relief in painful bullous keratopathy. METHODS: Twenty-five eyes of 25 patients with symptomatic bullous keratopathy and poor visual potential were randomized into 2 groups. In the PTK group (n = 13) after manual epithelial debridement, 100-microm excimer laser ablation was performed. In the AMT group (n = 12), the corneal epithelium was scraped and cryopreserved amniotic membrane with basement membrane side up was secured with 10-0 monofilament nylon sutures...
September 2010: Cornea
Margareta Claesson, W John Armitage
PURPOSE: To determine factors influencing graft survival and visual outcome 10 years after penetrating keratoplasty. METHODS: Ten-year follow-up data were obtained from a cohort of patients that represented 20% of corneal transplants in Sweden between 1996 and 1998. Multiple regression analyses (logistic and linear) were performed on graft survival and visual outcome (visual acuity and astigmatism). RESULTS: Of the initial 242 patients receiving a corneal transplant during 1996-1998, 140 were available at 10 years...
December 2009: Cornea
M Busin
PURPOSE: To evaluate the learning curve and the outcome of Descemet Automated Endothelial Keratoplasty (DSAEK) in patients with primary or secondary endothelial decompensation. METHODS: DSAEK was performed in 100 eyes with endothelial decompensation (Fuchs' Dystrophy n = 59; pseudophakic bullous keratopathy n = 33; failed corneal graft n = 8). All patients underwent a standard procedure including the following steps: Descemet membrane and endothelium removal from the recipient cornea under air; inferior peripheral iridectomy; microkeratome-assisted preparation of a donor lamella consisting of deep stroma and endothelium (between 100 and 200 micron in thickness), which is punched to desired size (8...
September 2009: Klinische Monatsblätter Für Augenheilkunde
Rong-Mei Peng, Yan-Sheng Hao, Hui-Jin Chen, Yan-Xiu Sun, Jing Hong
PURPOSE: To explore the feasibility of reattaching the dislocated graft with viscoelastic in abnormally structured eyes after Descemet-stripping automated endothelial keratoplasty (DSAEK). DESIGN: Retrospective case series. PARTICIPANTS: Five pseudophakic bullous keratopathy cases (5 eyes) with a history of vitrectomy and/or iris-lens diaphragm injury. METHODS: After DSAEK, graft dislocation occurred in each of the 5 cases (5 eyes)...
October 2009: Ophthalmology
Dalia G Said, Mario Nubile, Thaer Alomar, Andy Hopkinson, Trevor Gray, James Lowe, Harminder S Dua
PURPOSE: To evaluate the histologic changes occurring in the transplanted amniotic membrane in human eyes. DESIGN: Observational consecutive case series. PARTICIPANTS: Seven consecutive patients who underwent amniotic membrane transplantation (AMT) for bullous keratopathy and subsequently had a penetrating keratoplasty (PK). METHODS: Corneal buttons obtained at PK were examined by light and electron microscopy and by immunohistology with antibodies against CD34 (keratocytes), alpha smooth muscle actin and vimentin (myofibroblasts and fibroblasts respectively)...
July 2009: Ophthalmology
Ugur E Altiparmak, Yusuf Oflu, Elvin H Yildiz, Koray Budak, Bekir Sitki Aslan, Ayse Nurozler, Mustafa Onat, Remzi Kasim, Sunay Duman
PURPOSE: To determine the outcomes of a modified amniotic membrane transplantation (AMT) suturing technique for pain and discomfort relief in patients with symptomatic bullous keratopathy (BK). DESIGN: Randomized, double-blind controlled clinical trial. METHODS: setting: Ankara Research and Training Hospital 1st and 2nd Eye Clinics, Ankara, Turkey. study population: This prospective study included 39 eyes (39 patients) with BK presenting with intractable pain or discomfort and poor visual potential...
March 2009: American Journal of Ophthalmology
Jung Hyun Park, Jin Wook Jeoung, Won Ryang Wee, Jin Hak Lee, Mee Kum Kim, Jae Lim Lee
PURPOSE: To investigate the efficacy of permanent amniotic membrane transplantation (AMT) for the treatment of various ocular surface diseases. METHODS: The medical records of 62 eyes from 58 patients who had undergone permanent AMT were reviewed. The amniotic patches were grafted for the treatment of neurotrophic ulcers (n=15), inflammatory corneal ulcers (n=15), scleral ulcers (n=11), painful bullous keratopathy (n=8) and pterygium as an adjuvant to a conjunctival autograft (n=13)...
April 2008: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
Renuka Srinivasan, Suchi Smitha T, Arvind Gupta, Subashini Kaliaperumal
PURPOSE: To report the occurrence of hypopyon iritis after primary, fresh amniotic membrane transplant (AMT). METHODS: A case report of a 65-year-old man who underwent AMT along with placement of hydrophilic contact lens for symptomatic relief of pseudophakic bullous keratopathy for the first time. The amniotic membrane (AM) transplanted was obtained freshly after an elective cesarean section. RESULTS: The patient developed hypopyon on the second postoperative day...
December 2007: Cornea
Sujata Das, Balasubramanya Ramamurthy, Virender S Sangwan
PURPOSE: To report a case of fungal keratitis following amniotic membrane (AM) transplantation for pseudophakic bullous keratopathy. METHOD: A 55-year-old female underwent amniotic membrane transplantation (AMT) with epithelial debridement and anterior stromal puncture in the left eye for symptomatic bullous keratopathy. She developed fungal keratitis after 4 weeks. RESULT: Aspergillus sp. was isolated from the corneal scraping. The patient was treated with systemic and topical antifungal medication...
February 2009: International Ophthalmology
Valerie P J Saw, Darwin Minassian, John K G Dart, Andrew Ramsay, Hugo Henderson, Stefan Poniatowski, Ruth M Warwick, Suzanne Cabral
BACKGROUND: Amniotic membrane transplantation (AMT), as a new tool in the armamentarium of therapies available for ocular surface problems, became widely available in the UK in 1998. This study evaluates the indications for treatment, the surgical procedures used, and the results of a subset of the first AMT cases carried out by the group using this nationally available supply. This user group model provides data which is different from that obtained from uncontrolled case series, or clinical trials, and may be more representative of the outcomes that can be expected when a procedure becomes widely available...
August 2007: British Journal of Ophthalmology
S Srinivas, E Mavrikakis, C Jenkins
PURPOSE: To establish the effectiveness of amniotic membrane transplantation (AMT) in relieving pain and discomfort in patients with painful bullous keratopathy and its role in improving vision in eyes with visual potential. METHODS: Seven eyes of seven consecutive patients with painful corneal conditions were included in a retrospective interventional noncomparative case series performed at Maidstone General hospital, Maidstone, UK. Amniotic membrane transplantation was performed in seven eyes...
January 2007: European Journal of Ophthalmology
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