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random evaluation of recurrent stroke comparing PFO closure to established current standard of therapy

Abdur R Khan, Aref A Bin Abdulhak, Mujeeb A Sheikh, Sobia Khan, Patricia J Erwin, Imad Tleyjeh, Sadik Khuder, Ehab A Eltahawy
OBJECTIVES: This study sought to perform a meta-analysis of randomized controlled trials comparing device closure with medical therapy in the prevention of recurrent neurological events in patients with cryptogenic stroke and patent foramen ovale. BACKGROUND: The optimal strategy for secondary prevention of cryptogenic stroke with a patent foramen ovale is unclear. METHODS: Several databases were searched from their inception to March 2013, which yielded 3 eligible studies...
December 2013: JACC. Cardiovascular Interventions
Anthony J Furlan, Marek Jauss
Despite 3 recent randomized clinical trials, the management of patients with cryptogenic stroke and patent foramen ovale remains unsettled. The primary results of Evaluation of the STARFlex Septal Closure System in Patients with a Stroke and/or Transient Ischemic Attack due to Presumed Paradoxical Embolism Through a Patent Foramen Ovale (CLOSURE), Percutaneous Closure of Patent Foramen Ovale in Cryptogenic Stroke (PC), and Randomized Evaluation of Recurrent Stroke Comparing PFO Closure to Established Current Standard of Care Treatment (RESPECT) were the same; the intent to treat analysis for the primary end point in all 3 trials failed to demonstrate superiority of device closure compared with medical therapy...
September 2013: Stroke; a Journal of Cerebral Circulation
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