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Chronic fatigue

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https://www.readbyqxmd.com/read/28211165/a-disease-specific-quality-of-life-instrument-for-non-alcoholic-fatty-liver-disease-and-non-alcoholic-steatohepatitis-cldq-nafld
#1
Zobair M Younossi, Maria Stepanova, Linda Henry, Andrei Racila, Brian Lam, Huong T Pham, Sharon Hunt
BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are the most common causes of chronic liver disease with known negative impact on patients' health-related quality of life (HRQL). Our aim was to validate a disease-specific HRQL instrument useful for efficacy trials involving patients with NAFLD and NASH. METHODS: From a long item selection questionnaire, we selected relevant items which, by factor analysis, were grouped into domains constituting CLDQ-NAFLD...
February 17, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28207507/superiority-of-interferon-free-regimens-for-chronic-hepatitis-c-the-effect-on-health-related-quality-of-life-and-work-productivity
#2
Zobair M Younossi, Maria Stepanova, Rafael Esteban, Ira Jacobson, Stefan Zeuzem, Mark Sulkowski, Linda Henry, Fatema Nader, Rebecca Cable, Mariam Afendy, Sharon Hunt
Patient-reported outcomes (PROs) such as quality of life and work productivity are important for measuring patient's experience. We assessed PROs during and after treatment of hepatitis C virus (HCV) patients.Data were obtained from a phase 3 open label study of sofosbuvir and ribavirin (SOF + RBV) with and without interferon (IFN). Patients completed 4 PRO assessment instruments (SF-36, Functional Assessment of Chronic Illness Therapy-Fatigue, Chronic Liver Disease Questionnaire- HCV, Work Productivity and Activity-Specific Health Problem) before, during, and after treatment...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28205112/autochthonous-sporadic-acute-hepatitis-e-caused-by-two-distinct-subgenotype-3b-hepatitis-e-virus-strains-with-only-90-nucleotide-identity
#3
Yasuko Yamaguchi, Hitoshi Takagi, Yuhei Suzuki, Kyoko Maruhashi, Takashi Kosone, Satoru Kakizaki, Ken Sato, Masanobu Yamada, Shigeo Nagashima, Masaharu Takahashi, Hiroaki Okamoto
Hepatitis E, which is caused by hepatitis E virus (HEV), is a public health concern in Japan, where the zoonotic food-borne transmission of HEV from domestic pigs and wild boars plays an important role. A 44-year-old Japanese man with autochthonous sporadic acute hepatitis E was admitted with general fatigue and moderate liver dysfunction. In the present study, two distinct HEV strains were recovered from the patient, who had consumed the raw or undercooked pig liver and intestine two or three times per week for 3 months before the disease onset...
February 15, 2017: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/28198635/impact-of-comorbidities-by-age-on-symptom-presentation-for-suspected-acute-coronary-syndromes-in-the-emergency-department
#4
Larisa A Burke, Anne G Rosenfeld, Mohamud R Daya, Karen M Vuckovic, Jessica K Zegre-Hemsey, Maria Felix Diaz, Josemare Tosta Daiube Santos, Sahereh Mirzaei, Holli A DeVon
BACKGROUND: It is estimated half of acute coronary syndrome (ACS) patients have one or more associated comorbid conditions. AIMS: Aims were to: 1) examine the prevalence of comorbid conditions in patients presenting to the emergency department with symptoms suggestive of ACS; 2) determine if comorbid conditions influence ACS symptoms; and 3) determine if comorbid conditions predict the likelihood of receiving an ACS diagnosis. METHODS: A total of 1064 patients admitted to five emergency departments were enrolled in this prospective study...
February 1, 2017: European Journal of Cardiovascular Nursing
https://www.readbyqxmd.com/read/28197341/a-mixed-methods-small-pilot-study-to-describe-the-effects-of-upper-limb-training-using-a-virtual-reality-gaming-system-in-people-with-chronic-stroke
#5
Rachel C Stockley, Deborah A O'Connor, Phil Smith, Sylvia Moss, Lizzie Allsop, Wendy Edge
Introduction. This small pilot study aimed to examine the feasibility of an upper limb rehabilitation system (the YouGrabber) in a community rehabilitation centre, qualitatively explore participant experiences, and describe changes after using it. Methods and Material. Chronic stroke participants attending a community rehabilitation centre in the UK were randomised to either a YouGrabber or a gym group and completed 18 training sessions over 12 weeks. The motor activity log, box and block, and fatigue severity score were administered by a blinded assessor before and after the intervention...
2017: Rehabilitation Research and Practice
https://www.readbyqxmd.com/read/28194809/prodromal-symptoms-in-hidradenitis-suppurativa
#6
H C Ring, P Theut Riis, K Zarchi, I M Miller, D M Saunte, G B Jemec
BACKGROUND: Hidradenitis suppurativa (HS) is a chronic, inflammatory skin disease, which presents as recurrent nodules and sinus tracts (tunnels) with subsequent scarring, predominantly involving the intertriginous regions. Although prodromal symptoms (i.e. various symptoms preceding the eruption of the HS lesions) are often mentioned, there have been no formal investigations into this aspect. Insight into prodromal symptoms may enable patients with HS or dermatologists in choosing a more targeted treatment at a much earlier stage, potentially increasing treatment efficacy and quality of life...
February 14, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28193888/interleukin-37-reverses-the-metabolic-cost-of-inflammation-increases-oxidative-respiration-and-improves-exercise-tolerance
#7
Giulio Cavalli, Jamie N Justice, Kristen E Boyle, Angelo D'Alessandro, Elan Z Eisenmesser, Jonathan J Herrera, Kirk C Hansen, Travis Nemkov, Rinke Stienstra, Cecilia Garlanda, Alberto Mantovani, Douglas R Seals, Lorenzo Dagna, Leo A B Joosten, Dov B Ballak, Charles A Dinarello
IL-1 family member interleukin 37 (IL-37) has broad antiinflammatory properties and functions as a natural suppressor of innate inflammation. In this study, we demonstrate that treatment with recombinant human IL-37 reverses the decrease in exercise performance observed during systemic inflammation. This effect was associated with a decrease in the levels of plasma and muscle cytokines, comparable in extent to that obtained upon IL-1 receptor blockade. Exogenous administration of IL-37 to healthy mice, not subjected to an inflammatory challenge, also improved exercise performance by 82% compared with vehicle-treated mice (P = 0...
February 13, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28191605/integrating-palliative-care-into-routine-care-of-patients-with-heart-failure-models-for-clinical-collaboration
#8
REVIEW
Warren H Lewin, Kristen G Schaefer
Heart failure (HF) affects nearly 5.7 million Americans and is described as a chronic incurable illness carrying a poor prognosis. Patients living with HF experience significant symptoms including dyspnea, pain, anxiety, fatigue, and depression. As the illness advances into later stages, symptoms become more intense and refractory to standard treatments, leading to recurrent acute-care utilization and contributing to poor quality of life. Advanced HF symptoms have been described to be as burdensome, if not more than, those in cancer populations...
February 13, 2017: Heart Failure Reviews
https://www.readbyqxmd.com/read/28186393/chronic-fatigue-in-ehlers-danlos-syndrome-hypermobile-type
#9
Alan Hakim, Inge De Wandele, Chris O'Callaghan, Alan Pocinki, Peter Rowe
Chronic fatigue is an important contributor to impaired health-related quality of life in Ehlers-Danlos syndrome. There is overlap in the symptoms and findings of EDS and chronic fatigue syndrome. A proportion of those with CFS likely have EDS that has not been identified. The evaluation of chronic fatigue in EDS needs to include a careful clinical examination and laboratory testing to exclude common causes of fatigue including anemia, hypothyroidisim, and chronic infection, as well as dysfunction of major physiological or organ systems...
February 10, 2017: American Journal of Medical Genetics. Part C, Seminars in Medical Genetics
https://www.readbyqxmd.com/read/28186390/pain-management-in-the-ehlers-danlos-syndromes
#10
Pradeep Chopra, Brad Tinkle, Claude Hamonet, Isabelle Brock, Anne Gompel, Antonio Bulbena, Clair Francomano
Chronic pain in the Ehlers-Danlos syndromes (EDS) is common and may be severe. According to one study, nearly 90% of patients report some form of chronic pain. Pain, which is often one of the first symptoms to occur, may be widespread or localized to one region such as an arm or a leg. Studies on treatment modalities are few and insufficient to guide management. The following is a discussion of the evidence regarding the underlying mechanisms of pain in EDS. The causes of pain in this condition are multifactorial and include joint subluxations and dislocations, previous surgery, muscle weakness, proprioceptive disorders, and vertebral instability...
February 10, 2017: American Journal of Medical Genetics. Part C, Seminars in Medical Genetics
https://www.readbyqxmd.com/read/28184193/altered-functional-performance-in-patients-with-fibromyalgia
#11
Isis da Silva Costa, Antoni Gamundí, José G Vivas Miranda, Lucas G Souza França, Charles Novaes De Santana, Pedro Montoya
Fibromyalgia is a common chronic pain condition that exerts a considerable impact on patients' daily activities and quality of life. Objectives: The main objective of the present study was to evaluate kinematic parameters of gait, functional performance, and balance in women with fibromyalgia syndrome. Methods: The study included 26 female patients with fibromyalgia (49.2 ± 8.0 years) according to the criteria of the American College of Rheumatology, as well as 16 pain-free women (43.5 ± 8.5 years). Gait and balance parameters were extracted from video recordings of participants performing several motor tasks...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28183406/long-term-economic-evaluation-of-cognitive-behavioural-group-treatment-versus-enhanced-usual-care-for-functional-somatic-syndromes
#12
Andreas Schröder, Eva Ørnbøl, Jens S Jensen, Michael Sharpe, Per Fink
OBJECTIVE: Patients with functional somatic syndromes (FSS) such as fibromyalgia and chronic fatigue syndrome have a poor outcome and can incur high healthcare and societal costs. We aimed to compare the medium-term (16months) cost-effectiveness and the long-term (40months) economic outcomes of a bespoke cognitive-behavioural group treatment (STreSS) with that of enhanced usual care (EUC). METHODS: We obtained complete data on healthcare and indirect costs (i.e...
March 2017: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/28183399/efficacy-of-a-randomized-controlled-self-regulation-based-physical-activity-intervention-for-chronic-fatigue-mediation-effects-of-physical-activity-progress-and-self-regulation-skills
#13
M M Marques, V de Gucht, I Leal, S Maes
OBJECTIVE: Examine the medium-term effects of a brief physical activity (PA) self-regulation (SR) based intervention (4-STEPS program) for chronic fatigue, and explore the mediating effects of PA related variables and SR skills. METHODS: A two-arm randomized controlled trial (Usual Care vs 4-STEPS) was carried out. The 4-STEPS program consisted of Motivational Interviewing and SR-skills training. Fatigue severity (primary outcome) and impact, PA, health-related quality of life (HrQoL), and somatic and psychological distress were assessed at baseline, post-treatment (12weeks) and 12months follow-up...
March 2017: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/28182834/the-impact-of-moving-from-a-widespread-to-multi-site-pain-definition-on-other-fibromyalgia-symptoms
#14
Linda E Dean, Lesley Arnold, Leslie Crofford, Robert Bennett, Don Goldenberg, Mary-Ann Fitzcharles, Eduardo S Paiva, Roland Staud, Dan Clauw, Piercarlo Sarzi-Puttini, Gareth T Jones, Abimbola Ayorinde, Elisa Fluß, Marcus Beasley, Gary J Macfarlane
OBJECTIVES: The current study investigated whether associations between pain and the additional symptoms associated with fibromyalgia are different in persons with chronic widespread (CWP) compared to multi-site pain (MSP), with or without joint areas. PATIENTS/METHODS: Six studies were utilized: 1958 British birth cohort, EpiFunD, Kid LBP, MUSICIAN, SHAMA and WHEST (females) studies. MSP was defined as the presence of pain in ≥8/≥10 body sites (adults/children) indicated on 4-view body manikins; conducted firstly to include joints (+joints) and secondly without (-joints)...
February 9, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28182255/fatigue-in-psoriasis-a-controlled-study
#15
I M Skoie, I Dalen, T Ternowitz, G Jonsson, I Kvivik, K Norheim, R Omdal
BACKGROUND: Fatigue is associated with various chronic inflammatory diseases, but few studies have focused on its occurrence in psoriasis. OBJECTIVES: To describe fatigue prevalence and degree among patients with chronic plaque psoriasis compared with age- and gender-matched healthy subjects, and to examine how fatigue is influenced by essential clinical and demographic factors. METHODS: In 84 patients and 84 healthy subjects, fatigue severity was assessed using three different generic fatigue instruments: the fatigue Visual Analogue Scale (fVAS), the Fatigue Severity Scale (FSS), and the Short Form 36 (SF-36) vitality scale...
February 9, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28178174/real-world-experience-with-interferon-free-direct-acting-antiviral-therapies-in-asian-americans-with-chronic-hepatitis-c-and-advanced-liver-disease
#16
Christine Y Chang, Pauline Nguyen, An Le, Changqing Zhao, Aijaz Ahmed, Tami Daugherty, Gabriel Garcia, Glen Lutchman, Radhika Kumari, Mindie H Nguyen
Real-life data on interferon (IFN)-free direct acting antiviral (DAA) therapies for chronic hepatitis C (CHC) is limited for Asian Americans.To evaluate sustained virologic response (SVR) and adverse events (AE) in Asian Americans treated with sofosbuvir (SOF)-based, IFN-free DAA therapies.This is a retrospective study of 110 consecutive Asian Americans with HCV genotypes 1 to 3 or 6 treated with IFN-free SOF-based regimens for 8 to 24 weeks between February 2014 and March 2016 at a university center in Northern California...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28177596/evaluating-metrics-of-responsiveness-using-patient-reported-outcome-measures-in-chronic-rhinosinusitis
#17
Alcina K Lidder, Kara Y Detwiller, Caroline P E Price, Robert C Kern, David B Conley, Stephanie Shintani-Smith, Kevin C Welch, Rakesh K Chandra, Anju T Peters, Leslie C Grammer, Li-Xing Man, Robert P Schleimer, Bruce K Tan
BACKGROUND: Responsiveness, or sensitivity to clinical change, is important when selecting patient-reported outcome measures (PROMs) for research and clinical applications. This study compares responsiveness of PROMs used in chronic rhinosinusitis (CRS) to inform the future development of a highly responsive instrument that accurately portrays CRS patients' symptom experiences. METHODS: Adult CRS patients initiating medical therapy (MT; n = 143) or undergoing endoscopic sinus surgery after failing MT (ESS; n = 123) completed the 22-item Sino-Nasal Outcome Test (SNOT-22), European Position Statement on Rhinosinusitis (EPOS) visual analog scale (VAS), and 29-item Patient-Reported Outcomes Measurement Information System (PROMIS-29) at baseline and 3 months after treatment...
February 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28167659/targeting-btk-with-ibrutinib-in-relapsed-refractory-marginal-zone-lymphoma
#18
Ariela Noy, Sven de Vos, Catherine Thieblemont, Peter Martin, Christopher R Flowers, Franck Morschhauser, Graham P Collins, Shuo Ma, Morton Coleman, Shachar Peles, Stephen Smith, Jacqueline C Barrientos, Alina Smith, Brian Munneke, Isaiah Dimery, Darrin M Beaupre, Robert Chen
Marginal zone lymphoma (MZL) is a heterogeneous B-cell malignancy for which no standard treatment exists. MZL is frequently linked to chronic infection, which may induce B-cell receptor (BCR) signaling resulting in aberrant B-cell survival and proliferation. We conducted a multicenter, open-label, phase 2 study to evaluate the efficacy and safety of ibrutinib in previously treated MZL. Patients with histologically-confirmed MZL of all subtypes who received ≥1 prior therapy with an anti-CD20 antibody-containing regimen were treated with ibrutinib 560 mg orally once daily until progression or unacceptable toxicity...
February 6, 2017: Blood
https://www.readbyqxmd.com/read/28162843/a-sociological-stance-on-fatigue-and-tiredness-social-inequalities-norms-and-representations
#19
Marc Loriol
Fatigue is complex, representing simultaneously a physiological, psychological and social phenomenon. The sociological approach attempts to understand the experience of fatigue and its characterization at diverse periods and in various social contexts. After giving a sociological history of different forms of fatigue through the ages (acedia, melancholy, neurasthenia, chronic fatigue syndrome, etc.), this article proposes a social epidemiology of fatigue in the current period. Objectification of working and living conditions allows us to illustrate social inequalities in fatigue and exhaustion, but seems to contradict dominant social representations of fatigue today...
February 2, 2017: Neurophysiologie Clinique, Clinical Neurophysiology
https://www.readbyqxmd.com/read/28162735/-484-resistance-exercise-training-in-gulf-war-veterans-with-chronic-unexplained-muscle-pain-impact-on-pain-fatigue-mood-and-global-impression-of-change
#20
A Stegner, D Cook
No abstract text is available yet for this article.
April 2016: Journal of Pain: Official Journal of the American Pain Society
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