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hydroxytyrosol

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https://www.readbyqxmd.com/read/28720933/bioaccessibility-of-hydroxytyrosol-and-n-3-fatty-acids-as-affected-by-the-delivery-system-simple-double-and-gelled-double-emulsions
#1
Susana Cofrades, Ricard Bou, Linda Flaiz, Alba Garcimartín, Juana Benedí, Raquel Mateos, Francisco J Sánchez-Muniz, Raúl Olivero-David, Francisco Jiménez-Colmenero
This study examines the influence of different food-grade n-3 PUFA-enriched simple emulsion (SE), double emulsion (DE) and gelled double emulsion (GDE) delivery systems on the extent of lipolysis, antioxidant capacity and the bioaccessibility of hydroxytyrosol (HTy). GDE emulsion offered better protection for HTy (89%) than the other systems (79% in SE and DE). The reducing capacity of the emulsions containing HTy were not altered during oral digestion. However, "in vitro" gastric and intestinal phases significantly reduced the antioxidant activity of all systems...
June 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28718667/hydroxytyrosol-induces-apoptosis-and-cell-cycle-arrest-and-suppresses-multiple-oncogenic-signaling-pathways-in-prostate-cancer-cells
#2
Haseeb Zubair, Arun Bhardwaj, Aamir Ahmad, Sanjeev Kumar Srivastava, Mohammad Aslam Khan, Girijesh Kumar Patel, Seema Singh, Ajay Partap Singh
SCOPE: Hydroxytyrosol (HT), a polyphenol from olives, is a potential anticancer agent. This study was designed to evaluate the anticancer activity of HT against prostate cancer cells, and the mechanism thereof. METHODS AND RESULTS: Treatment of LNCaP and C4-2 prostate cancer cells with HT resulted in a dose-dependent inhibition of proliferation. This was in contrast to HT's ineffectiveness against normal prostate epithelial cells RWPE1 and PWLE2, suggesting cancer-cell-specific effect...
July 18, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/28711992/oleuropein-and-hydroxytyrosol-inhibit-the-n-formyl-methionyl-leucyl-phenylalanine-induced-neutrophil-degranulation-and-chemotaxis-via-akt-p38-and-erk1-2-map-kinase-inhibition
#3
Samia Bedouhene, Farida Moulti-Mati, Pham My-Chan Dang, Jamel El-Benna
PURPOSE: Oleuropein and hydroxytyrosol are polyphenols that are extracted from olives and are major biological active components of olives and olive oil. Oleuropein and hydroxytyrosol exhibit interesting pharmacological effects on cells, and have been shown to have many health benefits such as anti-inflammatory effects. These effects were mainly attributed to their ability to scavenge the reactive oxygen species (ROS) produced by phagocytes such as neutrophils. The aim of this study was to investigate the effect of oleuropein and hydroxytyrosol on other neutrophil functions...
July 15, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28689060/proteomic-evaluation-of-mouse-adipose-tissue-and-liver-following-hydroxytyrosol-supplementation
#4
João Tomé-Carneiro, M Carmen Crespo, Estefanía García-Calvo, José L Luque-García, Alberto Dávalos, Francesco Visioli
BACKGROUND AND AIMS: Hydroxytyrosol (HT) is the primary phenolic compound of olives, virgin olive oil, and their byproducts. Proteomic analysis of metabolically active tissues helps elucidating novel mechanisms of action and potential targets in cardiometabolic disease. Thus, we aimed at determining the impact of long-term HT supplementation on the proteome of adipose and liver tissue, in mice. METHODS: C57BL/6J mice received either a control diet or a diet supplemented with nutritionally relevant doses of HT for eight weeks...
July 5, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28673363/a-red-yeast-rice-olive-extract-supplement-reduces-biomarkers-of-oxidative-stress-oxldl-and-lp-pla2-in-subjects-with-metabolic-syndrome-a-randomised-double-blind-placebo-controlled-trial
#5
Nina Hermans, Anastasia Van der Auwera, Annelies Breynaert, Annelies Verlaet, Tess De Bruyne, Luc Van Gaal, Luc Pieters, Veronique Verhoeven
BACKGROUND: Metabolic syndrome (MetS) refers to clustered cardiovascular risk factors (abdominal obesity, pre-diabetes, high blood pressure, dyslipidaemia). Therapies targeting oxidative stress may delay progression to atherosclerosis and diabetes. We investigated the anti-oxidative effect of a supplement combining red yeast rice and olive extract in patients with MetS. METHODS: A double-blind, placebo-controlled, randomised trial was conducted with 50 patients with MetS as defined by National Cholesterol Education Program Adult Treatment Panel III criteria...
July 3, 2017: Trials
https://www.readbyqxmd.com/read/28662386/phenols-recovery-after-steam-explosion-of-olive-mill-solid-waste-and-its-influence-on-a-subsequent-biomethanization-process
#6
Antonio Serrano, Fernando G Fermoso, Bernabé Alonso-Fariñas, Guillermo Rodríguez-Gutierrez, Juan Fernandez-Bolaños, Rafael Borja
A promising source of high added value compounds is the Olive Mill Solid Waste (OMSW). The aim of this research was to evaluate the viability of a biorefinery approach to valorize OMSW through the combination of steam explosion, phenols extraction, and anaerobic digestion. Steam explosion treatment increased the total phenol content in the steam exploited OMSW, which was twice than that the total phenol content in raw OMSW, although some undesirable compounds were also formed. Phenol extraction allowed the recovery of 2098mg hydroxytyrosol per kg of OMSW...
June 20, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28579756/effect-of-a-food-supplement-containing-berberine-monacolin-k-hydroxytyrosol-and-coenzyme-q10-on-lipid-levels-a-randomized-double-blind-placebo-controlled-study
#7
Sergio D'Addato, Luciana Scandiani, Giuliana Mombelli, Francesca Focanti, Federica Pelacchi, Enrica Salvatori, Giorgio Di Loreto, Alessandro Comandini, Pamela Maffioli, Giuseppe Derosa
PURPOSE: To evaluate the ability of the new food supplement, Body Lipid (BL), containing red yeast rice, berberine, coenzyme Q10 and hydroxytyrosol, to lower the LDL-C in patients with mild-to-moderate hypercholesterolemia and to assess the overall safety profile of the product. METHODS: In this multicenter, randomized, double-blind, placebo and active comparator (the marketed Armolipid Plus(®) [AM]) controlled study, 158 hypercholesterolemic patients were randomized following a 4-week dietary run-in period...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28576392/enzymatic-tailoring-of-oleuropein-from-olea-europaea-leaves-and-product-identification-by-hrms-ms-spectrometry
#8
Efstratios Nikolaivits, Aikaterini Termentzi, Alexios-Leandros Skaltsounis, Nikolas Fokialakis, Evangelos Topakas
Oleuropein, a bioactive compound found in all parts of olive tree, especially in leaves and branches, presents numerous health promoting properties that increase research and market interest the last few years. In addition, oleuropein degradation products, such as hydroxytyrosol, elenolic acid, and the aglycones also exhibit biological activities with different properties compared to the starting compound. Under this view, a commercial lipase preparation Lipolase 100L and a thermophilic β-glucosidase from Myceliophthora thermophila were used for the regioselective hydrolysis of oleuropein towards the production of the corresponding biologically active compounds...
May 30, 2017: Journal of Biotechnology
https://www.readbyqxmd.com/read/28570659/caffeic-acid-and-hydroxytyrosol-have-anti-obesogenic-properties-in-zebrafish-and-rainbow-trout-models
#9
Esmail Lutfi, Patrick J Babin, Joaquim Gutiérrez, Encarnación Capilla, Isabel Navarro
Some natural products, known sources of bioactive compounds with a wide range of properties, may have therapeutic values in human health and diseases, as well as agronomic applications. The effect of three compounds of plant origin with well-known dietary antioxidant properties, astaxanthin (ATX), caffeic acid (CA) and hydroxytyrosol (HT), on zebrafish (Danio rerio) larval adiposity and rainbow trout (Onchorynchus mykiss) adipocytes was assessed. The zebrafish obesogenic test (ZOT) demonstrated the anti-obesogenic activity of CA and HT...
2017: PloS One
https://www.readbyqxmd.com/read/28566694/production-of-three-phenylethanoids-tyrosol-hydroxytyrosol-and-salidroside-using-plant-genes-expressing-in-escherichia-coli
#10
Daeun Chung, So Yeon Kim, Joong-Hoon Ahn
Polyphenols, which include phenolic acids, flavonoids, stilbenes, and phenylethanoids, are generally known as useful antioxidants. Tyrosol, hydroxytyrosol, and salidroside are typical phenylethanoids. Phenylethanoids are found in plants such as olive, green tea, and Rhodiola and have various biological activities, including the prevention of cardiovascular diseases, cancer, and brain damage. We used Escherichia coli to synthesize three phenylethanoids, tyrosol, hydroxytyrosol, and salidroside. To synthesize tyrosol, the aromatic aldehyde synthase (AAS) was expressed in E...
May 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28554640/inhibition-of-%C3%AE-glucosidase-and-%C3%AE-amylase-by-spanish-extra-virgin-olive-oils-the-involvement-of-bioactive-compounds-other-than-oleuropein-and-hydroxytyrosol
#11
Jacinta Collado-González, Clara Grosso, Patricia Valentão, Paula B Andrade, Federico Ferreres, Thierry Durand, Alexandre Guy, Jean-Marie Galano, Arturo Torrecillas, Ángel Gil-Izquierdo
Despite the wide use of extra virgin olive oil (EVOO) to combat several diseases, the antidiabetic and anti-cholinesterase activity of Spanish EVOO have not been assessed. In order to evaluate which compounds are responsible for these activities of five Spanish EVOOs, in addition to flavonoids, we investigated for the first time the effect of the contents of carotenoids, fatty acids (FAs), and phytoprostanes (PhytoPs) on four enzymes: α-glucosidase, α-amylase, acetylcholinesterase, and butyrylcholinesterase...
November 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28545153/polyphenols-and-iugr-pregnancies-maternal-hydroxytyrosol-supplementation-improves-prenatal-and-early-postnatal-growth-and-metabolism-of-the-offspring
#12
Marta Vazquez-Gomez, Consolación Garcia-Contreras, Laura Torres-Rovira, José Luis Pesantez, Pedro Gonzalez-Añover, Ernesto Gomez-Fidalgo, Raúl Sanchez-Sanchez, Cristina Ovilo, Beatriz Isabel, Susana Astiz, Antonio Gonzalez-Bulnes
Hydroxytyrosol is a polyphenol with antioxidant, metabolism-regulatory, anti-inflammatory and immuno-modulatory properties. The present study aimed to determine whether supplementing the maternal diet with hydroxytyrosol during pregnancy can improve pre- and early post-natal developmental patterns and metabolic traits of the offspring. Experiment was performed in Iberian sows fed a restricted diet in order to increase the risk of IUGR. Ten sows were treated daily with 1.5 mg of hydroxytyrosol per kg of feed between Day 35 of pregnancy (30% of total gestational period) until delivery whilst 10 animals were left untreated as controls...
2017: PloS One
https://www.readbyqxmd.com/read/28538693/preparation-characterization-and-antioxidant-activity-evaluation-of-liposomes-containing-water-soluble-hydroxytyrosol-from-olive
#13
Jiao-Jiao Yuan, Frank G F Qin, Jun-Ling Tu, Bing Li
Due to the multiple hydroxyl groups in its structure, hydroxytyrosol (HT) is very sensitive to air and light and has very strong instability and hydrophilicity that affect its biological activity. This study attempted to prepare liposomes containing water-soluble HT to improve the bioavailability and biocompatibility of the target drug. The preparation process factors (temperature, mass ratio of phospholipid (PL) and cholesterol (CH), Tween-80 volume, HT mass) were studied and response surface methodology (RSM) was applied to optimize the conditions...
May 24, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28503711/bioactivity-improvement-of-olea-europaea-leaf-extract-biotransformed-by-wickerhamomyces-anomalus-enzymes
#14
Rosa Palmeri, Cristina Restuccia, Julieta Ines Monteleone, Elisa Sperlinga, Laura Siracusa, Mauro Serafini, Alberto Finamore, Giovanni Spagna
Olive leaves represent a quantitatively significant by-product of agroindustry. They are rich in phenols, mainly oleuropein, which can be hydrolyzed into several bioactive compounds, including hydroxytyrosol. In this study, water extract from olive leaves 'Biancolilla' was analyzed for polyphenol profile, DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging activity and protective effect on differentiated Caco-2 cells. The efficacy of two enzymatic treatments in promoting the release of bioactive phenols was investigated: a) enzymatic extract from Wickerhamomyces anomalus, characterized by β-glucosidase and esterase activities; b) commercial β-glucosidase...
June 2017: Plant Foods for Human Nutrition
https://www.readbyqxmd.com/read/28486416/transcriptomics-and-the-mediterranean-diet-a-systematic-review
#15
REVIEW
Luis V Herrera-Marcos, José M Lou-Bonafonte, Carmen Arnal, María A Navarro, Jesús Osada
The Mediterranean diet has been proven to be highly effective in the prevention of cardiovascular diseases and cancer and in decreasing overall mortality. Nowadays, transcriptomics is gaining particular relevance due to the existence of non-coding RNAs capable of regulating many biological processes. The present work describes a systematic review of current evidence supporting the influence of the Mediterranean diet on transcriptomes of different tissues in various experimental models. While information on regulatory RNA is very limited, they seem to contribute to the effect...
May 9, 2017: Nutrients
https://www.readbyqxmd.com/read/28481539/reverse-micelles-as-antioxidant-carriers-an-experimental-and-molecular-dynamics-study
#16
Maria D Chatzidaki, Konstantinos D Papavasileiou, Manthos G Papadopoulos, Aristotelis Xenakis
Water-in-oil microemulsions with biocompatible components were formulated to be used as carriers of natural antioxidants, such as hydroxytyrosol (HT) and gallic acid (GA). The system was composed of a mixture of natural surfactants, lecithin and monoglycerides, medium chain triglycerides, and aqueous phase. A dual approach was undertaken to study the structure and dynamics of these complicated systems. First, experimental data were collected by using adequate techniques, such as dynamic light scattering (DLS) and electron paramagnetic resonance (EPR) spectroscopy...
May 12, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28481240/soft-ms-and-computational-mapping-of-oleuropein
#17
REVIEW
Luigi Gentile, Nicola A Uccella, Ganapathy Sivakumar
Olive oil and table olives are rich sources of biophenols, which provides a unique taste, aroma and potential health benefits. Specifically, green olive drupes are enriched with oleuropein, a bioactive biophenol secoiridoid. Olive oil contains hydrolytic derivatives such as hydroxytyrosol, oleacein and elenolate from oleuropein as well as tyrosol and oleocanthal from ligstroside. Biophenol secoiridoids are categorized by the presence of elenoic acid or its derivatives in their molecular structure. Medical studies suggest that olive biophenol secoiridoids could prevent cancer, obesity, osteoporosis, and neurodegeneration...
May 6, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28453363/a-polyphenol-based-multicomponent-nutraceutical-in-dysmetabolism-and-oxidative-stress-results-from-a-pilot-study
#18
Roberto Corsi, Giovanni Mosti, Attilio Cavezzi, Simone Ugo Urso, Gayla Dimitrova, Elena Fioroni, Roberto Colucci, Valentina Quinzi
To assess short-term efficacy and safety of a multicomponent nutraceutical (MCN) on dysmetabolism and oxidative stress, a pilot prospective observational study was performed on 21 individuals (12 men and 9 women) who took, for 60 days, 2 tablets per day of an MCN based on antioxidants and metabolism regulators: hydroxytyrosol (15 mg), maqui (300 mg), amla (200 mg), monacolin K (10 mg), berberine (245 mg), astaxanthin (0.5 mg), coenzyme Q10 (100 mg), and folic acid (200 mcg). On day 0 (T0) and day 60 (T60), all participants underwent laboratory tests related to lipid profile, carbohydrate metabolism, oxidative stress, and cellular inflammation...
April 28, 2017: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/28452954/hydroxytyrosol-and-cytoprotection-a-projection-for-clinical-interventions
#19
REVIEW
Francisca Echeverría, Macarena Ortiz, Rodrigo Valenzuela, Luis A Videla
Hydroxytyrosol (HT) ((3,4-Dihydroxyphenyl)ethanol) is a polyphenol mainly present in extra virgin olive oil (EVOO) but also in red wine. It has a potent antioxidant effect related to hydrogen donation, and the ability to improve radical stability. The phenolic content of olive oil varies between 100 and 600 mg/kg, due to multiple factors (place of cultivation, climate, variety of the olive and level of ripening at the time of harvest), with HT and its derivatives providing half of that content. When consumed, EVOO's phenolic compounds are hydrolyzed in the stomach and intestine, increasing levels of free HT which is then absorbed in the small intestine, forming phase II metabolites...
April 28, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28446500/protective-effect-of-homovanillyl-alcohol-on-cardiovascular-disease-and-total-mortality-virgin-olive-oil-wine-and-catechol-methylathion
#20
Rafael De la Torre, Dolores Corella, Olga Castañer, Miguel A Martínez-González, Jordi Salas-Salvador, Joan Vila, Ramón Estruch, José V Sorli, Fernando Arós, Miquel Fiol, Emili Ros, Lluís Serra-Majem, Xavier Pintó, Enrique Gómez-Gracia, José Lapetra, Miguel Ruiz-Canela, José Basora, Eva Maria Asensio, Maria Isabel Covas, Montserrat Fitó
Background: Hydroxytyrosol is a phenolic compound that is present in virgin olive oil (VOO) and wine. Hydroxytyrosol-related foods have been shown to protect against cardiovascular disease (CVD).Objective: We investigated the associations between hydroxytyrosol and its biological metabolite, 3-O-methyl-hydroxytyrosol, also known as homovanillyl alcohol (HVAL), with CVD and total mortality.Design: We included 1851 men and women with a mean ± SD age of 66.8 ± 6 y at high risk of CVD from prospective cohort data...
June 2017: American Journal of Clinical Nutrition
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