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hydroxytyrosol

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https://www.readbyqxmd.com/read/27916128/a-paper-based-platform-with-a-pencil-drawn-dual-amperometric-detector-for-the-rapid-quantification-of-ortho-diphenols-in-extravirgin-olive-oil
#1
Nicolò Dossi, Rosanna Toniolo, Flavia Impellizzieri, Franco Tubaro, Gino Bontempelli, Fabio Terzi, Evandro Piccin
A simple, sensitive and fast responding device is described for the discrimination of hydrophilic ortho-diphenols, whose presence in abundant enough amounts is typical for extra virgin olive oils (EVOOs), from hydrophilic mono-phenols instead present in almost all vegetable oils. It consists of a dual electrode detector pencil-drawn at the end of a paper microfluidic channel, defined by hydrophobic barriers, where samples of these antioxidants, extracted from vegetable oils by a 80:20% v/v acetonitrile/water mixture, were applied...
January 15, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/27914878/hydroxytyrosol-modulates-the-levels-of-microrna-9-and-its-target-sirtuin-1-thereby-counteracting-oxidative-stress-induced-chondrocyte-death
#2
Stefania D'Adamo, Silvia Cetrullo, Serena Guidotti, Rosa Maria Borzì, Flavio Flamigni
OBJECTIVE: Nutraceutical compounds, such as hydroxytyrosol (HT), have been found to exert protective effects in osteoarthritis (OA) by affecting a variety of key molecular and cellular processes in chondrocytes. However, to our knowledge, no relationship has been reported between nutraceuticals and microRNA (miR) network in OA models. Here, we identified a miR that is implicated in hydroxytyrosol (HT)-mediated chondroprotection following oxidative stress condition by targeting sirtuin-1 (SIRT-1)...
November 30, 2016: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/27913892/early-harvest-effects-on-hydrophilic-phenolic-components-of-extra-virgin-olive-oils-cvs-ayval%C3%A4-k-memecik-and-topaka%C3%A5-%C3%A4
#3
Fatma Yıldırım, Adnan Nurhan Yıldırım, Gülcan Özkan, Bekir Şan, Mehmet Polat, Hatice Aşık, Yaşar Karakurt, Sezai Ercişli
The study was conducted to determine the effects of cultivar, harvest period, and their interaction on the hydrophilic phenolic components extra virgin olive oils of the cultivars 'Ayvalık,' 'Memecik,' and 'Topakaşı.' Olives were collected at three different harvesting periods: (1) early harvest period-1 (Beginning of spotting), (2) early harvest period-2 (End of spotting), and (3) optimum harvest period. Oils were extracted using the Abencor system. HPLC (High-performance liquid chromatograph) technique was used to quantify the phenolic compounds including tyrosol (p-HPEA), hydroxytyrosol (3,4-DHPEA), luteolin, rutin, quercetin, catechin, sinapinic acid, p-coumaric acid, cinnamic acid, vanillin, vanillic acid, ferulic acid, and gallic acid...
December 2, 2016: Biochemical Genetics
https://www.readbyqxmd.com/read/27908553/olive-polyphenol-effects-in-a-mouse-model-of-chronic-ethanol-addiction
#4
Valentina Carito, Mauro Ceccanti, Vincenzo Cestari, Fausta Natella, Cristiano Bello, Roberto Coccurello, Rosanna Mancinelli, Marco Fiore
OBJECTIVES: Alcohol addiction elicits oxidative imbalance and it is well known that polyphenols possess antioxidant properties. We investigated whether or not polyphenols could confer a protective potential against alcohol-induced oxidative stress. METHODS: We administered (per os) for two months 20 mg/kg of olive polyphenols containing mostly hydroxytyrosol in alcoholic adult male mice. Hydroxytyrosol metabolites as hydroxytyrosol sulfate 1 and hydroxytyrosol sulfate 2 were found in the serum of mice administered with polyphenols with the highest amount in animals treated with both polyphenols and alcohol...
January 2017: Nutrition
https://www.readbyqxmd.com/read/27907867/adsorption-characteristics-of-adsorbent-resins-and-antioxidant-capacity-for-enrichment-of-phenolics-from-two-phase-olive-waste
#5
Zhihong Wang, Chengzhang Wang, Jiaojiao Yuan, Changwei Zhang
In this study, the adsorption properties of nine resins including polyamide resin (30-60), polyamide resin (60-100) AB-8, S-8, D-101, NKA-9, NKA-II, XDA-1 and XDA-4 for enrichment phenolics of the olive waste were investigated. XDA-1 and NKA-II were chosen for further study due to their outstanding adsorption and desorption capacity. XDA-1 and NKA-II had similar adsorption and desorption behaviors for phenolics of olive waste. The adsorption mechanism could be better explained by pseudo second-order kinetics model and Freundlich isotherm model, and the adsorption processes were spontaneously and exothermic...
November 24, 2016: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/27889243/antiprotozoal-and-antioxidant-alkaloids-from-alternanthera-littoralis
#6
Hector H F Koolen, Elizabeth M F Pral, Silvia C Alfieri, Jane V N Marinho, Alessandra F Serain, Alvaro J Hernández-Tasco, Nathalia L Andreazza, Marcos J Salvador
Five alkaloids, in addition to hydroxytyrosol and uridine, were isolated from aerial parts of Alternanthera littoralis P. Beauv. Among the isolated compounds, alternamide A was an unusual tricyclic alkaloid with a bridged benzoazepine core. All isolated alkaloids have a catechol moiety, indicating a possible common biosynthetic route. Their structures were established by 1D and 2D NMR spectroscopy in combination with extensive tandem MS experiments by collisional induced dissociation (CID). The antiprotozoal activity of the isolated compounds was assayed against trypomastigote forms of Trypanosoma cruzi and amastigotes of Leishmania amazonensis...
November 23, 2016: Phytochemistry
https://www.readbyqxmd.com/read/27883159/melatonin-and-hydroxytyrosol-rich-wines-influence-the-generation-of-dna-oxidation-catabolites-linked-to-mutagenesis-after-the-ingestion-of-three-types-of-wine-by-healthy-volunteers
#7
Javier Marhuenda, Sonia Medina, Pedro Martínez-Hernández, Simón Arina, Pilar Zafrilla, Juana Mulero, Hans-Gottfried Genieser, Federico Ferreres, Ángel Gil-Izquierdo
The Mediterranean Diet (MD) has been proved to exert benefits with respect to the maintenance of the redox balance, and wine is a representative component. Bioactive compounds such as polyphenols, melatonin and hydroxytyrosol act as radical scavengers and regulate the oxidation status of organisms. Oxidative damage to DNA yields a large range of end products. The repair of oxidized DNA entails the removal of the useless bases and/or nucleotides as well as the release of circulating nucleotides and nucleosides...
November 24, 2016: Food & Function
https://www.readbyqxmd.com/read/27862176/inflammasomes-hormesis-and-antioxidants-in-neuroinflammation-role-of-nrlp3-in-alzheimer-disease
#8
REVIEW
Manuela Pennisi, Rosalia Crupi, Rosanna Di Paola, Maria Laura Ontario, Rita Bella, Edward J Calabrese, Roberto Crea, Salvatore Cuzzocrea, Vittorio Calabrese
Alzheimer disease (AD) is a progressive neurodegenerative disorder leading to cognitive decline, neuropsychiatric symptoms, disability, caregiver burden, and premature death. It represents the most prevalent cause of dementia, and its incidence rates exponentially increase with increasing age. The number of Americans living with AD is rapidly increasing. An estimated 5.4 million Americans of all ages have AD in 2016. One in nine people aged 65 and older has AD, and by midcentury, someone in the United States will develop the disease every 33 sec...
November 8, 2016: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/27826066/plant-polyphenols-as-natural-drugs-for-the-management-of-down-syndrome-and-related-disorders
#9
REVIEW
Rosa Anna Vacca, Daniela Valenti, Salvatore Caccamese, Maria Daglia, Nady Braidy, Seyed Mohammad Nabavi
Polyphenols are secondary metabolites of plants largely found in fruits, vegetables, cereals and beverages, and therefore represent important constituents of the human diet. Increasing studies have demonstrated the potential beneficial effects of polyphenols on human health. Extensive reviews have discussed the protective effects of polyphenols against a series of diseases such as cancer, cardiovascular diseases, diabetes, and neurodegenerative disorders. Limited studies have investigated the potential therapeutic effects of these natural compounds on neurodevelopmental disorders associated with intellectual disability, such as Down syndrome (DS), for which mitochondrial dysfunctions and oxidative stress are hallmarks and contribute to the deleterious symptoms and cognitive decline...
December 2016: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/27810738/hydroxytyrosol-inhibits-hydrogen-peroxide-induced-apoptotic-signaling-via-labile-iron-chelation
#10
Natalia Kitsati, Michalis D Mantzaris, Dimitrios Galaris
Although it is known that Mediterranean diet plays an important role in maintaining human health, the underlying molecular mechanisms remain largely unknown. The aim of this investigation was to elucidate the potential role of ortho-dihydroxy group containing natural compounds in H2O2-induced DNA damage and apoptosis. For this purpose, the main phenolic alcohols of olive oil, namely hydroxytyrosol and tyrosol, were examined for their ability to protect cultured cells under conditions of oxidative stress. A strong correlation was observed between the ability of hydroxytyrosol to mitigate intracellular labile iron level and the protection offered against H2O2-induced DNA damage and apoptosis...
October 15, 2016: Redox Biology
https://www.readbyqxmd.com/read/27803730/quick-assessment-of-the-economic-value-of-olive-mill-waste-water
#11
Riccardo Delisi, Filippo Saiano, Mario Pagliaro, Rosaria Ciriminna
BACKGROUND: Olive biophenols are emerging as a valued class of natural products finding practical application in the food, pharmaceutical, beverage, cosmetic and nutraceutical industries due to their powerful biological activity which includes antioxidant and antimicrobial properties. Olive mill waste water (OMWW), a by-product in olive oil manufacturing, is rich in biophenols such as hydroxytyrosol and tyrosol. The amount of biophenols depends on the cultivar, the geographical area of cultivation, and the seasonal conditions...
2016: Chemistry Central Journal
https://www.readbyqxmd.com/read/27798770/impact-of-a-proprietary-standardized-olive-fruit-extract-sofe-on-cardio-ankle-vascular-index-visual-analog-scale-and-c-reactive-protein-assessments-in-subjects-with-arterial-stiffness-risk
#12
Pilar Pais, Agustin Villar, Santiago Rull
INTRODUCTION: The chemical components of olive fruit provide a wide range of cardiovascular benefits. Arterial stiffness is an important cardiovascular risk factor and can be assessed using the Cardio-Ankle Vascular Index (CAVI). OBJECTIVE: The objective of this study was to assess the impact of a proprietary standardized olive fruit extract (SOFE) in subjects at risk for arterial stiffness. METHODS: Twelve of 36 subjects were assigned to each of the following groups for this 11-day, double-blind, placebo-controlled study: Group 1: 250 mg SOFE-50 mg active ingredient, hydroxytyrosol (dosage achieved with two capsules per day); Group 2: 500 mg SOFE-100 mg active ingredient, hydroxytyrosol (dosage achieved with two capsules per day); and Group 3: placebo...
December 2016: Drugs in R&D
https://www.readbyqxmd.com/read/27765236/influence-of-ph-on-the-antioxidant-phenols-solubilised-from-hydrothermally-treated-olive-oil-by-product-alperujo
#13
Fátima Rubio-Senent, Juan Fernández-Bolaños, Aránzazu García-Borrego, Antonio Lama-Muñoz, Guillermo Rodríguez-Gutiérrez
The application of a novel industrial process based on the hydrothermal treatment of olive oil waste (alperujo) led to a final liquid phase that contained a high concentration of simple phenolic compounds. In this study the effect of pH on phenol extraction with ethyl acetate from the aqueous phase of hydrothermally treated alperujo at 160°C/60min (without modification, pH 4.5, and adjusted to pH 2.5) was evaluated, beside the increase of hydroxytyrosol during the storage. The variation of the concentration of phenolic compounds in each extract was analyzed by HPLC...
March 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27719659/cardioprotective-effects-of-the-polyphenol-hydroxytyrosol-from-olive-oil
#14
Silvia Tejada, Samuel Pinya, Maria Del Mar Bibiloni, Josep A Tur, Antoni Pons, Antoni Sureda
The Mediterranean diet includes olive oil as its primary source of fat. This diet is frequently associated to longevity and a lower incidence of chronic diseases thanks to its biological activities and health effects. Apart from oleic acid, olive oil contains many bioactive components including polyphenols that have been reported to exert antioxidant and anti-inflammatory activities. Polyphenols may for the most part be responsible for the protective effects against cardiovascular diseases associated with olive oil...
October 5, 2016: Current Drug Targets
https://www.readbyqxmd.com/read/27713969/effect-of-bactrocera-oleae-on-phenolic-compounds-and-antioxidant-and-antibacterial-activities-of-two-algerian-olive-cultivars
#15
Lynda Medjkouh, Abderezak Tamendjari, Rita C Alves, Mariana Araújo, M Beatriz P P Oliveira
Bactrocera oleae, an olive fruit fly, is a major olive pest in Algeria. In this study, olives of two Algerian cultivars (Limli and Rougette de Métidja) with different degrees of infestation by the Bactrocera oleae fly (0%, not attacked; 100%, all attacked; and real %) were analysed. The influence of this pest on individual phenolic compounds (HPLC-DAD-FLD) and antioxidant profiles was ascertained. The antibacterial activity against 8 human enteropathogenic bacteria was also assessed. The results show that Rougette de Métidja, the cultivar with higher drupe size, was attacked to a greater degree than Limli, and the B...
October 12, 2016: Food & Function
https://www.readbyqxmd.com/read/27713961/anti-cancer-properties-of-olive-oil-secoiridoid-phenols-a-systematic-review-of-in-vivo-studies
#16
R Fabiani
Epidemiological studies suggest that olive oil intake is associated to a reduced risk of cancer. Recently, the chemopreventive activity of olive oil has been attributed to its unique phenolic compounds represented by phenolic alcohols, hydroxytyrosol (3,4-dihydroxyphenylethanol: 3,4-DHPEA) and tyrosol (p-hydroxyphenylethanol: p-HPEA), and their secoiridoid derivatives 3,4-DHPEA-EA (oleuropein aglycon), p-HPEA-EA (ligstroside aglycon), 3,4-DHPEA-EDA, p-HPEA-EDA (oleocanthal), and oleuropein. Several studies have demonstrated that these compounds are able to inhibit proliferation and induce apoptosis in different tumor cell lines...
October 12, 2016: Food & Function
https://www.readbyqxmd.com/read/27700999/chemical-composition-and-direct-electrochemical-oxidation-of-table-olive-processing-wastewater-using-high-oxidation-power-anodes
#17
Boutheina Gargouri, Olfa Dridi Gargouri, Ibtihel Khmakhem, Sonda Ammar, Ridha Abdelhèdi, Mohamed Bouaziz
Table olive processing wastewater (TOW) is a notoriously polluting due to its high organic and phenol content. To reduce them, an electrochemical process has been studied for the treatment of this effluent. Experiments were performed with a cell equipped with lead dioxide (PbO2) or boron-doped diamond (BDD) as anode and platinum as cathode, where Table Olive Wastewater (TOW) were destroyed by hydroxyl radicals formed at the anode surface from water oxidation. The comparative study of both systems shows the performance of the BDD anode compared to PbO2, explained by the large amounts of hydroxyl radicals generated effective at BDD anode and its synthesis characteristics...
January 2017: Chemosphere
https://www.readbyqxmd.com/read/27700078/neuroprotective-effect-of-hydroxytyrosol-in-experimental-diabetes-mellitus
#18
José Julio Reyes, Beatriz Villanueva, Juan Antonio López-Villodres, José Pedro De La Cruz, Lidia Romero, María Dolores Rodríguez-Pérez, Guillermo Rodríguez-Gutiérrez, Juan Fernández-Bolaños, José Antonio González-Correa
The aim of this study was to determine whether the administration of hydroxytyrosol (HT) to diabetic animals exerts a neuroprotective effect on brain damage in a model of hypoxia-reoxygenation. Rats (10 per group) were distributed in five groups: nondiabetic rats, control diabetic rats (DR), and DR rats treated for 2 months with 1, 5 or 10 mg/kg/day p.o. HT. At the end of follow-up an experimental model of hypoxia-reoxygenation in brain slices was tested. The DR group showed increased cell death, oxidative and nitrosative stress and an increase in brain inflammatory mediators...
October 4, 2016: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/27677167/hydroxytyrosol-a-new-class-of-microbicide-displaying-broad-anti-hiv-1-activity
#19
Luis M Bedoya, Manuela Beltrán, Patricia Obregón-Calderón, Javier García-Pérez, Humberto E de la Torre, Nuria González, Mayte Pérez-Olmeda, David Auñón, Laura Capa, Eduardo Gómez-Acebo, José Alcamí
OBJECTIVE: To investigate the toxicity and activity against HIV of 5-hydroxytyrosol as a potential microbicide. DESIGN: The anti-HIV-1 activity of 5-hydroxytyrosol, a polyphenolic compound, was tested against wild-type HIV-1 and viral clones resistant to nucleoside reverse transcriptase inhibitors (NRTIs), non-nucleoside reverse transcriptase inhibitors (NNRTIs), protease inhibitors and integrase inhibitors. In addition to its activity against founder viruses, different viral subtypes and potential synergy with tenofovir disoproxil fumarate, lamivudine and emtricitabine was also tested...
November 28, 2016: AIDS
https://www.readbyqxmd.com/read/27664690/cyp2d6-and-cyp2a6-biotransform-dietary-tyrosol-into-hydroxytyrosol
#20
Jose Rodríguez-Morató, Patricia Robledo, Julie-Anne Tanner, Anna Boronat, Clara Pérez-Mañá, C-Y Oliver Chen, Rachel F Tyndale, Rafael de la Torre
The dietary phenol tyrosol has been reported to be endogenously transformed into hydroxytyrosol, a potent antioxidant with multiple health benefits. In this work, we evaluated whether tyrosine hydroxylase (TH) and cytochrome P450s (CYPs) catalyzed this process. To assess TH involvement, Wistar rats were treated with α-methyl-L-tyrosine and tyrosol. Tyrosol was converted into hydroxytyrosol whilst α-methyl-L-tyrosine did not inhibit the biotransformation. The role of CYP was assessed in human liver microsomes (HLM) and tyrosol-to-hydroxytyrosol conversion was observed...
February 15, 2017: Food Chemistry
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