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Aurélia Malapert, Valerie Tomao, Olivier Dangles, Emmanuelle Reboul
Hydroxytyrosol bioaccessibility and absorption by the intestinal cells have been studied using an in vitro digestion model and Caco-2 TC7 monolayers cells in culture, in the presence or absence of β-cyclodextrin and foods. Hydroxytyrosol was either provided as a pure standard or in an alperujo powder. The presence of foods significantly decreased hydroxytyrosol bioaccessibility and absorption (-20% and -10%, respectively), while β-cyclodextrin had no effect. Moreover, the presence of other compounds from alperujo in the intestine compartment reduced hydroxytyrosol absorption by Caco-2 cells compared to pure standard (-60%)...
April 17, 2018: Journal of Agricultural and Food Chemistry
Juan Zenon Davalos, Ana C Valderrama-Negrón, Julio Barrios, Vera L S Freitas, Maria D M C Ribeiro da Silva
Theoretical and experimental studies on the energetic, structural and some other relevant physicochemical properties of the antioxidant tyrosol (1), hydroxytyrosol (1OH) molecules and the corresponding radicals 1rad• and 1Orad• are reported in this work. The experimental values of the gas-phase enthalpy of formation, (g), in kJ·mol-1, of 1 (-302.4  3.4) and 1OH (-486.3 ± 4.1) have been determined. Quantum chemical calculations, at DFT (M05-2X) and composite ab initio G3 and G4 levels of theory, provided results that served to: i/ confirm the excellent consistency of the experimental measurements performed, ii/ establish that the stabilizing effect of H-bond of hydroxyethyl chain and aromatic ring (OH••• interaction) is smaller in radicals than in parent molecules, iii/ deduce - combining experimental data in isodesmic reactions - (g) of radicals 1rad• (-152...
April 4, 2018: Journal of Physical Chemistry. A
Roberto Carnevale, Romano Silvestri, Lorenzo Loffredo, Marta Novo, Vittoria Cammisotto, Valentina Castellani, Simona Bartimoccia, Cristina Nocella, Francesco Violi
AIMS: Extra virgin olive oil (EVOO) lowers post-prandial glycaemia. We investigated if oleuropein, a component of EVOO, exerts a similar effect on post-prandial glycaemia and the underlying mechanism. METHODS: Twenty healthy subjects were randomly allocated in a cross-over design to 20 mg oleuropein or placebo immediately before lunch. Post-prandial glycaemia along with blood insulin, dipeptidyl-peptidase-4 (DPP-4) and glucagon-like peptide-1 (GLP-1) and oxidative stress, which included Nox2 activity(sNox2-dp), 8-iso-PGF2α and platelet p47phox phosphorylation, were analysed before and two hours after meal...
March 26, 2018: British Journal of Clinical Pharmacology
Hasan Kırmızıbekmez, Yiğit İnan, Rengin Reis, Hande Sipahi, Ahmet C Gören, Erdem Yeşilada
Phytochemical investigations on the EtOH extract of Clematis viticella led to the isolation of six flavonoid glycosides, isoorientin (1), isoorientin 3'-O-methyl ether (2), quercetin 7-O-α-L-rhamnopyranoside (3), quercetin 3,7-di-O-α-L-rhamnopyranoside (4), manghaslin (5) and chrysoeriol 7-O-β-D-glucopyranoside (6), one phenylethanol derivative, hydroxytyrosol (7), along with three phenolic acids, caffeic acid (8), (E)-p-coumaric acid (9) and p-hydroxybenzoic acid (10). The structures of the isolates were elucidated on the basis of NMR and HR-MS data...
March 12, 2018: Natural Product Research
Maria Aponte, Francesca Ungaro, Ivana d'Angelo, Carmen De Caro, Roberto Russo, Giuseppe Blaiotta, Fabrizio Dal Piaz, Antonio Calignano, Agnese Miro
This study reports novel food-grade granules for co-delivery of L. plantarum 299v and a standardized extract of Olea europaea leaves (Phenolea®) as oral carrier of probiotics and hydroxytyrosol. Different granule formulations containing either L. plantarum 299v (Lac), or the olive leave extract (Phe) or their combination (Lac-Phe) have been successfully produced through wet granulation employing excipients generally regarded as safe as granulating/binding agents. L. plantarum cells withstood the manufacturing process and were stable upon storage at 4°C for more than 6 months...
March 8, 2018: International Journal of Pharmaceutics
Manisha Soni, Chandra Prakash, Rajesh Dabur, Vijay Kumar
The present study reports beneficial effect of hydroxytyrosol (HT) against arsenic (As)-induced oxidative stress in the rat brain. Rats were orally administered with sodium arsenite dissolved in distilled water (25 ppm, by oral gavage) for 8 weeks or HT (10 mg/kg b. wt.) in combination with As. Results showed increase in protein oxidation and lipid peroxidation, while catalase and superoxide dismutase (SOD) activities as well as GSH content were decreased after As exposure in rat brain. Fourier transform infrared analysis showed significant alteration in peak area values that also validated the oxidative damage to lipids and proteins...
March 2, 2018: Applied Biochemistry and Biotechnology
Qingling Cui, Yingni Pan, Wei Zhang, Yanan Zhang, Shumeng Ren, Dongmei Wang, Zhenzhong Wang, Xiaoqiu Liu, Wei Xiao
In recent years, Cistanche tea has been increasingly used as a main herbal supplement in functional drinks, and it has attracted a growing number of consumers due to its excellent tonic effect and medicinal properties. Acteoside (ACT), which acts as the principal bioactive component of Chinese Cistanche tea, possesses various pharmacological effects. This study was investigated the profile, isolation, identification and hepatoprotective capacity of the metabolites in rat urine after taking of ACT. 11 metabolites, including one new compound (M8), were obtained and identified by nuclear magnetic resonance (NMR) for the first time...
February 24, 2018: Journal of Agricultural and Food Chemistry
Nuri El-Azem, Mario Pulido-Moran, Cesar L Ramirez-Tortosa, Jose L Quiles, Francisca E Cara, Pedro Sanchez-Rovira, Sergio Granados-Principal, MCarmen Ramirez-Tortosa
PURPOSE: The main objective of this study was to test the therapeutic potential of hydroxytyrosol and its combination with paclitaxel in breast cancer on oxidative stress status. METHODS: Impact on proliferation rates of different chemotherapy administration patterns was assayed in MCF-7 and MDA-MB-231 breast cancer cell lines. Breast tumor-bearing rats were randomly assigned to Control, Hydroxytyrosol, Paclitaxel and Paclitaxel plus hydroxytyrosol groups, for 6 weeks...
February 21, 2018: European Journal of Nutrition
Jun-Ling Tu, Jiao-Jiao Yuan
The thermal decomposition behavior of olive hydroxytyrosol (HT) was first studied using thermogravimetry (TG). Cracked chemical bond and evolved gas analysis during the thermal decomposition process of HT were also investigated using thermogravimetry coupled with infrared spectroscopy (TG-FTIR). Thermogravimetry-Differential thermogravimetry (TG-DTG) curves revealed that the thermal decomposition of HT began at 262.8 °C and ended at 409.7 °C with a main mass loss. It was demonstrated that a high heating rate (over 20 K·min -1 ) restrained the thermal decomposition of HT, resulting in an obvious thermal hysteresis...
February 13, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
David Bars-Cortina, María-Carmen López de Las Hazas, Alfred Benavent-Vallés, Maria-José Motilva
A preliminary study to evaluate the effect of dietary supplementation with olive phenols (oleuropein, hydroxytyrosol and secoiridoids), thyme phenols and a combination of these (5 mg per kg rat weight per day) on the α-tocopherol concentrations in the muscle and liver of healthy adult Wistar rats over 21 days was conducted. In addition, the excretion of α-tocopherol through the faeces was examined. The results demonstrated that the diet supplemented with some phenolic compounds of olive and thyme increased α-tocopherol (P < 0...
February 13, 2018: Food & Function
María Robles-Almazan, Mario Pulido-Moran, Jorge Moreno-Fernandez, Cesar Ramirez-Tortosa, Carmen Rodriguez-Garcia, Jose L Quiles, MCarmen Ramirez-Tortosa
Many beneficial properties have been attributed to the Mediterranean diet. Over the years, researchers have attempted to learn which foods and which food components are responsible for good health. One of these components is hydroxytyrosol, an important phenolic compound present in olive oil. Hydroxytyrosol is a molecule of high interest to the pharmaceutical industry due to its anti-inflammatory and antimicrobial qualities its role against cardiovascular diseases and metabolic syndrome and for its neuroprotection, antitumour, and chemo modulation effects...
March 2018: Food Research International
Dennis Fiorini, Maria Chiara Boarelli, Paolo Conti, Barbara Alfei, Giovanni Caprioli, Massimo Ricciutelli, Gianni Sagratini, Donatella Fedeli, Rosita Gabbianelli, Deborah Pacetti
The aim of the study was to identify new potential chemical markers of extra virgin olive oil (EVOO) quality by using a multicomponent analysis approach. Sixty-six EVOOs were purchased from the Italian market and classified according to their price as low price EVOOs (LEVOOs) and high price EVOOs (HEVOOs) costing 3.60-5.90euro/L and 7.49-29.80euro/L respectively. Sensory and chemical parameters strictly related to olive oil quality have been investigated, like volatile substances, polar phenolic substances, antioxidant activity, fatty acid composition, and α-tocopherol...
March 2018: Food Research International
Min Liu, Qiang Yong, Shiyuan Yu
Hydroxytyrosol (HT), a powerful antioxidant, clears free radicals and exhibits many biological activities. Because contents of HT are low in natural sources, bioconversion of oleuropein (OLE) to HT is of increasing interest. A biotechnological process was investigated to produce HT from OLE presented in olive leaf extract. Enzymatic hydrolysis using two cellulases with high BG activity, Novozymes CTec2 and commercial cellulase KDN (Qingdao, China), was carried out at 50 °C for 12 h followed by raising the temperature to 90 °C for chemical hydrolysis...
February 10, 2018: Biotechnology and Applied Biochemistry
Elena Fernández, Lorena Vidal, Antonio Canals
A novel approach is presented to determine hydrophilic phenols in olive oil samples, employing vortex-assisted reversed-phase dispersive liquid-liquid microextraction (RP-DLLME) for sample preparation and screen-printed carbon electrodes for voltammetric analysis. The oxidation of oleuropein, hydroxytyrosol, caffeic acid, ferulic acid and tyrosol was investigated, being caffeic acid and tyrosol selected for quantification. A matrix-matching calibration using sunflower oil as analyte-free sample diluted with hexane was employed to compensate matrix effects...
May 1, 2018: Talanta
Rebecca Lynn Johnson, Eleni Melliou, Jerry A Zweigenbaum, Alyson Elayne Mitchell
Oleuropein, ligstroside and related hydrolysis products are key contributors to olive bitterness, and several of these phenolics are implicated in the prevention of lifestyle age-related diseases. While table olive processing methods are designed to reduce oleuropein the impact of processing on ligstroside and related hydrolysis products (e.g. oleacein, oleocanthal, hydroxytyrosol glucoside, ligstroside aglycone, and oleuropein aglycone) is relatively unknown. Herein, levels of these compounds were measured in Spanish-style green (SP), Californian-style black ripe (CA), and Greek-style natural fermentation (GK) olives using rapid ultrahigh-performance liquid chromatography (UHPLC)-tandem mass spectrometry (MS/MS)...
February 9, 2018: Journal of Agricultural and Food Chemistry
Yuyu Xu, Lixing Wu, Aochang Chen, Chaoqi Xu, Qing Feng
Many studies reported that air pollution particulate matter (PM) exposure was associated with myocardial infarction (MI). Acrolein representing the unsaturated aldehydes, the main component of PM, derives from the incomplete combustion of wood, plastic, fossil fuels and the main constitute of cigarette smoking. However, the effect of acrolein on MI remains not that clear. In the current study, the effect of acrolein-exacerbated MI was investigated. In vivo, male Sprague-Dawley rats received olive leaf extract (OLE) followed by acrolein, then isoprenaline (ISO) was received by subcutaneous injection to induce MI...
February 7, 2018: International Journal of Molecular Sciences
Serkan Selli, Hasim Kelebek, Songul Kesen, Ahmet Salih Sonmezdag
BACKGROUND: Processing the olives involves varying consumption habits depending on the country. Different de-bittering methods affects the aroma and aroma-active compounds of table olives. So, this study focused on analyse the aroma and aroma-active compounds of black dry-salted olives by using gas chromatography-mass spectrometry-olfactometry (GC-MS-O) techniques. RESULTS: A total of 39 volatile compounds with the content of 29,459 μg kg-1 were determined. Aroma extract dilution analysis (AEDA) was used for the determination of key aroma compounds of table olive...
February 1, 2018: Journal of the Science of Food and Agriculture
María Jesús Ramírez-Expósito, José Manuel Martínez-Martos
Functional roles of the angiotensin peptides of the renin-angiotensin system (RAS) cascade can be analyzed through their corresponding proteolytic regulatory enzymes aspartyl aminopeptidase (ASAP), aminopeptidase A (APA), aminopeptidase B (APB), aminopeptidase N (APN) and insulin-regulated aminopeptidase (IRAP). These enzyme activities generate active or inactive angiotensin peptides that alter the ratios between their bioactive forms, regulating several important processes such as the regulation of cardiovascular functions, body water regulation, normal memory consolidation and retrieval, but also cell growth, differentiation and apoptosis or the inflammatory response...
January 26, 2018: Biomedicines
Lucia Bartella, Fabio Mazzotti, Anna Napoli, Giovanni Sindona, Leonardo Di Donna
A rapid and reliable method to assay the total amount of tyrosol and hydroxytyrosol derivatives in extra virgin olive oil has been developed. The methodology intends to establish the nutritional quality of this edible oil addressing recent international health claim legislations (the European Commission Regulation No. 432/2012) and changing the classification of extra virgin olive oil to the status of nutraceutical. The method is based on the use of high-performance liquid chromatography coupled with tandem mass spectrometry and labeled internal standards preceded by a fast hydrolysis reaction step performed through the aid of microwaves under acid conditions...
March 2018: Analytical and Bioanalytical Chemistry
Lorena Martínez, Gaspar Ros, Gema Nieto
Hydroxytyrosol (HXT) is a phenolic compound drawn from the olive tree and its leaves as a by-product obtained from the manufacturing of olive oil. It is considered the most powerful antioxidant compound after gallic acid and one of the most powerful antioxidant compounds between phenolic compounds from olive tree followed by oleuropein, caffeic and tyrosol. Due to its molecular structure, its regular consumption has several beneficial effects such as antioxidant, anti-inflammatory, anticancer, and as a protector of skin and eyes, etc...
January 23, 2018: Medicines (Basel, Switzerland)
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