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https://www.readbyqxmd.com/read/28317728/direct-study-of-minor-extra-virgin-olive-oil-components-without-any-sample-modification-1-h-nmr-multisupression-experiment-a-powerful-tool
#1
Ainhoa Ruiz-Aracama, Encarnación Goicoechea, María D Guillén
Proton Nuclear Magnetic Resonance ((1)H NMR) was employed to study monovarietal commercial Spanish extra-virgin olive oils (EVOO) (Arbequina, Arroniz, Cornicabra, Hojiblanca and Picual). Each sample was analyzed by a standard pulse and by an experiment suppressing the main lipid signals, enabling the detection of signals of minor components. The aim was to determine the possibilities of both (1)H NMR approaches to characterize EVOO composition, focusing on acyl groups, squalene, sterols, triterpene acids/esters, fatty alcohols, wax esters and phenols (lignans, tyrosol, hydroxytyrosol, oleocanthal, oleacein, oleokoronal, oleomissional, ligstrodials and oleuropeindials), and to determine hydrolysis and oxidation levels...
August 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28317262/hydroxytyrosol-restores-proper-insulin-signaling-in-an-astrocytic-model-of-alzheimer-s-disease
#2
M Carmen Crespo, Joao Tomé-Carneiro, Cristina Pintado, Alberto Dávalos, Francesco Visioli, Emma Burgos-Ramos
Recent epidemiological evidence demonstrated that diabetes is a risk factor for AD onset and development. Indeed, meta-analyses of longitudinal epidemiologic studies show that diabetes increases AD risk by 50-100%, being insulin resistance (IR) the main binding link between diabetes and AD. Astrocytes are the foremost cerebral macroglial cells and are responsible for converting glucose into lactate and transfer it to neurons that use it as fuel, but Aβ(1-42) impairs insulin signaling and glycogen storage. Recent prospective studies showed that the Mediterranean diet is associated with lower incidence of AD...
March 20, 2017: BioFactors
https://www.readbyqxmd.com/read/28294699/chia-oil-enriched-restructured-pork-effects-on-oxidative-and-inflammatory-status-of-aged-rats-fed-high-cholesterol-high-fat-diets
#3
Jorge Arturo Santos-López, Alba Garcimartín, María Elvira López-Oliva, Mirandeli Bautista-Ávila, María José González-Muñoz, Sara Bastida, Juana Benedí, Francisco José Sánchez-Muniz
Chia oil has the highest recognized α-linolenic acid (ALA) content. ALA is associated with beneficial changes in plasma lipids and the prevention of cardiovascular diseases. Present article aims to analyze the effect of Chia oil-enriched restructured pork (RP) on aged rats in a nonalcoholic steatohepatitis (NASH) model. Groups of six male Wistar rats (1-year old) were fed the experimental diets: control RP diet (C) noncholesterol high saturated; cholesterol-enriched high-saturated fat/high-cholesterol control RP diet (HC) with added cholesterol and cholic acid; and Chia oil- or Hydroxytyrosol RP cholesterol-enriched high-saturated fat/high cholesterol (CHIA and HxT)...
March 15, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28290298/evaluation-of-an-olive-leaf-extract-as-a-natural-source-of-antiglycative-compounds
#4
Marta Navarro, Francisco J Morales
Advanced Glycation End-products (AGEs) have been associated to diabetes, neurodegenerative and cardiovascular diseases. Mitigating the formation of AGEs is a strategy to avoid detrimental physiopathological effects of age-related chronic diseases. An olive leaf extract (OLE), obtained under acidic conditions, and two fractions, obtained by solid-phase extraction, were characterized by LC-MS/MS. Antiglycative capacity of OLE and fractions were investigated in different in vitro models. The OLE significantly inhibited the formation of Amadori products at the early stage as well as the formation of fluorescent AGEs at the advanced stage of the glycation...
February 2017: Food Research International
https://www.readbyqxmd.com/read/28286236/5-hydroxytyrosol-inhibits-hiv-1-replication-in-primary-cells-of-the-lower-and-upper-female-reproductive-tract
#5
Elisa Saba, Paola Panina-Bordignon, Isabel Pagani, Massimo Origoni, Massimo Candiani, Claudio Doglioni, Gianluca Taccagni, Silvia Ghezzi, José Alcami, Elisa Vicenzi, Guido Poli
We investigated the potential anti-HIV-1 activity of the candidate microbicide 5-hydroxytyrosol (5-HT) both in primary human cervical tissue explants (CTE), established from tissues of women undergoing histerectomy, and in endometrium-associated leukocytes (EAL). CTE were exposed to either the laboratory-adapted HIV-1BaL or to primary viral isolates in the presence or absence of 5-HT or 3TC/lamivudine as control and were then monitored for 12 days in terms of HIV-1 p24 Gag antigen production in culture supernatants...
March 7, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28285526/lipophilization-of-hydroxytyrosol-enriched-fractions-from-olea-europaea-l-by-products-and-evaluation-of-the-in-vitro-effects-on-a-model-of-colorectal-cancer-cells
#6
Roberta Bernini, Isabella Carastro, Gaia Palmini, Annalisa Tanini, Roberto Zonefrati, Patrizia Pinelli, Maria Luisa Brandi, Annalisa Romani
A hydroxytyrosol (HTyr)-enriched fraction containing HTyr 6% w/w, derived from Olea europaea L. by-products, obtained using an environmentally and economically sustainable technology was lipophilized under green chemistry conditions. The effects of three fractions containing hydroxytyrosyl butanoate, octanoate and oleate and unreacted HTyr, named, respectively, lipophilic fraction 5, 6 and 7, on the human colon cancer cell line HCT8-β8 engineered to overexpress estrogen receptor  (ER) were evaluated and compared to those of pure HTyr...
March 12, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28267509/complexation-of-hydroxytyrosol-and-3-4-dihydroxyphenylglycol-with-pectin-and-their-potential-use-for-colon-targeting
#7
Alejandra Bermúdez-Oria, Guillermo Rodríguez-Gutiérrez, Fátima Rubio-Senent, Antonio Lama-Muñoz, Juan Fernández-Bolaños
Hydroxytyrosol (HT) and 3,4-dihydroxyphenylglycol (DHPG) are two phenolic antioxidants naturally found in olive fruit with anti-inflammatory properties. This study explored the interaction of pectin with HT and DHPG via their encapsulation into pectinate beads. Purification by size exclusion chromatography, changes in the fluorescence spectrum of the HT and pectin, and MALDI TOF-TOF analysis suggested the existence of the phenol-pectin complexes. The entrapment efficiency, swelling properties, and in vitro release of HT and DHPG of the beads were studied...
May 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28256253/an-integrated-process-for-the-recovery-of-high-added-value-compounds-from-olive-oil-using-solid-support-free-liquid-liquid-extraction-and-chromatography-techniques
#8
Apostolis Angelis, Mahmoud Hamzaoui, Nektarios Aligiannis, Theodora Nikou, Dimitris Michailidis, Panagiotis Gerolimatos, Aikaterini Termentzi, Jane Hubert, Maria Halabalaki, Jean-Hugues Renault, Alexios-Léandros Skaltsounis
An integrated extraction and purification process for the direct recovery of high added value compounds from extra virgin olive oil (EVOO) is proposed by using solid support free liquid-liquid extraction and chromatography techniques. Two different extraction methods were developed on a laboratory-scale Centrifugal Partition Extractor (CPE): a sequential strategy consisting of several "extraction-recovery" cycles and a continuous strategy based on stationary phase co-current elution. In both cases, EVOO was used as mobile phase diluted in food grade n-hexane (feed mobile phase) and the required biphasic system was obtained by adding ethanol and water as polar solvents...
March 31, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28229142/olive-leaf-extract-concentrated-in-hydroxytyrosol-attenuates-protein-carbonylation-and-the-formation-of-advanced-glycation-end-products-in-a-hepatic-cell-line-hepg2
#9
Marta Navarro, Francisco J Morales, Sonia Ramos
Glycation takes place both at the cellular level and at the extracellular matrix level and generates, consequently, advanced glycation end-products (AGEs) associated with chronic diseases and the aging process. Two olive leaf extracts concentrated in (i) oleuropein (OLE-A; 93.9 mg oleuropein g(-1)) and (ii) hydroxytyrosol (OLE-B; 54.5 mg hydroxytyrosol g(-1)) were evaluated according to their antiglycative and antioxidant capacity in vitro. OLE-B exerted the highest anti-AGE effect in different glycation models (IC50: 0...
February 23, 2017: Food & Function
https://www.readbyqxmd.com/read/28225195/protective-effect-of-hydroxytyrosol-in-arsenic-induced-mitochondrial-dysfunction-in-rat-brain
#10
Manisha Soni, Chandra Prakash, Sfurti Sehwag, Vijay Kumar
The present study was planned to investigate the protective effect of hydroxytyrosol (HT) against arsenic (As)-induced mitochondrial dysfunction in rat brain. Rats exposed to sodium arsenite (25 ppm for 8 weeks) showed decreased mitochondrial complexes (I, II, IV) activities, mitochondrial superoxide dismutase (MnSOD), and catalase activities in brain mitochondria. As-treated rats showed reduced mRNA expression of complex I (ND-1, ND-2), IV (COX-1, COX-4) subunits, and uncoupling protein-2 (UCP-2). In addition to this, As exposure downregulated the protein expression of MnSOD...
February 22, 2017: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/28170343/bioenergetic-strategy-of-microalgae-for-the-biodegradation-of-tyrosol-and-hydroxytyrosol
#11
Aikaterini Papazi, Andreas Ioannou, Myrto Symeonidi, Andreas G Doulis, Kiriakos Kotzabasis
Olive mill wastewater has significant polluting properties due to its high phenolic content [mainly tyrosol (trs) and hydroxytyrosol (htrs)]. Growth kinetics and a series of fluorescence induction measurements for Scenedesmus obliquus cultures showed that microalgae can be tolerant of these phenolic compounds. Changes in the cellular energy reserves and concentration of the phenolic compounds adjust the "toxicity" of these compounds to the microalgae and are, therefore, the main parameters that affect biodegradation...
February 7, 2017: Zeitschrift Für Naturforschung. C, A Journal of Biosciences
https://www.readbyqxmd.com/read/28133759/hydroxytyrosol-extracts-olive-oil-and-walnuts-as-functional-components-in-chicken-sausages
#12
Gema Nieto, Lorena Martínez, Gaspar Ros
BACKGROUND: Olive oil, hydroxytyrosol and walnut can be considered ideal Mediterranean ingredients for their high polyphenolic content and healthy properties. Three extracts of hydroxytyrosol obtained using different extraction process (HXT 1, 2, 3) (50 ppm) were evaluated for use as antioxidants in eight different chicken sausage formulas enriched in polyunsaturated fatty acids (2.5 g/100 g walnut) or using extra virgin olive oil (20 g/100 g) as fat replacer. Lipid and protein oxidation, colour, emulsion stability, and the microstructure of the resulting chicken sausages were investigated and a sensory analysis was carried out...
January 30, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28097900/structure-activity-relationships-of-fraxamoside-as-an-unusual-xanthine-oxidase-inhibitor
#13
Rosa Maria Vitale, Lina Antenucci, Margherita Gavagnin, Gennaro Raimo, Pietro Amodeo
Fraxamoside, a macrocyclic secoiridoid glucoside featuring a hydroxytyrosol group, was recently identified as a xanthine oxidase inhibitor (XOI) comparable in potency in vitro to the standard antigout drug allopurinol. However, this activity and its considerably higher value than its derivatives oleuropein, oleoside 11-methyl ester, and hydroxytyrosol are not explained by structure-activity relationships (SARs) of known XOIs. To exclude allosteric mechanisms, we first determined the inhibition kinetic of fraxamoside...
December 2017: Journal of Enzyme Inhibition and Medicinal Chemistry
https://www.readbyqxmd.com/read/28071793/antioxidant-effect-of-natural-table-olives-phenolic-extract-against-oxidative-stress-and-membrane-damage-in-enterocyte-like-cells
#14
Gabriele Serreli, Alessandra Incani, Angela Atzeri, Alberto Angioni, Marco Campus, Emanuele Cauli, Roberto Zurru, Monica Deiana
The phenolic fraction of a naturally fermented cultivar of table olives, "Tonda di Cagliari," was investigated for the ability to protect Caco-2 cells against oxidative stress and membrane damage induced by tert-butyl hydroperoxyde (TBH). TBH exposure resulted in an alteration of cellular redox status, with an increase in reactive oxygen species (ROS) and a decrease in reduced glutathione (GSH) level. A loss of the epithelial integrity, as indicated by the decrease of the transepithelial electrical resistance value, was also observed over time, together with an intense lipid peroxidation process...
January 10, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28071050/hydroxytyrosol-and-the-colonic-metabolites-derived-from-virgin-olive-oil-intake-induce-cell-cycle-arrest-and-apoptosis-in-colon-cancer-cells
#15
Maria-Carmen López de Las Hazas, Carme Piñol, Alba Macià, Maria-José Motilva
After the sustained consumption of virgin olive oil (VOO), the unabsorbed native phenols (mainly hydroxytyrosol (HT)) are transformed into its catabolites in the intestine by microbials. The role of these catabolites in preventing colon cancer has not been sufficiently investigated. This work aims to study the antiproliferative and apoptotic activities in colon (Caco-2; HT-29) cancer cell lines of the main catabolites detected in human feces (phenylacetic, phenylpropionic, hydroxyphenylpropionic, and dihydroxyphenylpropionic acids and catechol), after the sustained VOO intake...
January 19, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28063380/hydroxytyrosol-supplementation-increases-vitamin-c-levels-in-vivo-a-human-volunteer-trial
#16
Eduardo Lopez-Huertas, Juristo Fonolla
Hydroxytyrosol (HT) is a main phenolic component of olive oil. In this study, we investigated the safety and effects produced by HT purified (99.5%) from olive mill waste. HT was administered at a daily dosage of 45mg for 8 weeks to volunteers with mild hyperlipidemia (n=14). We measured markers of cardiovascular disease risk, enzyme markers of several clinical conditions, hematology, antioxidant parameters, vitamins and minerals at baseline (T0), 4 weeks (T4) and 8 weeks (T8). The values obtained at T4 and T8 were compared with baseline...
April 2017: Redox Biology
https://www.readbyqxmd.com/read/28024731/olive-oil-polyphenols-a-quantitative-method-by-high-performance-liquid-chromatography-diode-array-detection-for-their-determination-and-the-assessment-of-the-related-health-claim
#17
Massimo Ricciutelli, Shara Marconi, Maria Chiara Boarelli, Giovanni Caprioli, Gianni Sagratini, Roberto Ballini, Dennis Fiorini
In order to assess if an extra virgin olive oil (EVOO) can be acknowledged with the health claim related to olive oil polyphenols (Reg. EU n.432/2012), a new method to quantify these species in EVOO, by means of liquid-liquid extraction followed by HPLC-DAD/MS/MS of the hydroalcoholic extract, has been developed and validated. Different extraction procedures, different types of reverse-phase analytical columns (Synergi Polar, Spherisorb ODS2 and Kinetex) and eluents have been tested. The chromatographic column Synergi Polar (250×4...
January 20, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28012379/the-lc-ms-based-metabolomics-of-hydroxytyrosol-administration-in-rats-reveals-amelioration-of-the-metabolic-syndrome
#18
Nikolaos Lemonakis, Hemant Poudyal, Maria Halabalaki, Lindsay Brown, Anthony Tsarbopoulos, Alexios-Leandros Skaltsounis, Evagelos Gikas
Hydroxytyrosol (HT), an important component of olive fruit and olive oil, improves the signs of metabolic syndrome in rats following chronic treatment. At a dose of 20mg/kg/day, HT decreased adiposity and improved cardiovascular and liver structure and function in rats fed with a high-carbohydrate, high-fat diet. An untargeted metabolomics approach has been employed using both UPLC-Orbitrap and -QqTOF methods to identify the changes induced by chronic HT administration on the plasma metabolome. 31 metabolites have been found to be differentially expressed between the examined groups...
January 15, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/27999296/the-health-benefiting-mechanisms-of-virgin-olive-oil-phenolic-compounds
#19
REVIEW
Lisa Parkinson, Sara Cicerale
Virgin olive oil (VOO) is credited as being one of the many healthful components associated with the Mediterranean diet. Mediterranean populations experience reduced incidence of chronic inflammatory disease states and VOO is readily consumed as part of an everyday Mediterranean dietary pattern. VOO is rich in phenolic compounds and the health promoting benefits of these phenolics are now established. Recent studies have highlighted the biological properties of VOO phenolic compounds elucidating their anti-inflammatory activities...
December 16, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27998828/nutritionally-relevant-concentrations-of-resveratrol-and-hydroxytyrosol-mitigate-oxidative-burst-of-human-granulocytes-and-monocytes-and-the-production-of-pro-inflammatory-mediators-in-lps-stimulated-raw-264-7-macrophages
#20
Elisabetta Bigagli, Lorenzo Cinci, Sara Paccosi, Astrid Parenti, Mario D'Ambrosio, Cristina Luceri
The health benefits of bio-active phenolic compounds have been largely investigated in vitro at concentrations which exceed those reachable in vivo. We investigated and compared the anti-inflammatory effects of resveratrol, hydroxytyrosol and oleuropein at physiologically relevant concentrations by using in vitro models of inflammation. Human granulocytes and monocytes were stimulated with phorbol myristate acetate (PMA) and the ability of resveratrol, hydroxytyrosol and oleuropein to inhibit the oxidative burst and CD11b expression was measured...
February 2017: International Immunopharmacology
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